NADPH-hemoprotein reductase activity

description: Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.


NADPH dehydrogenase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor.


name: NADPH:quinone reductase activity

description: Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone.


description: Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers.


cystathionine gamma-synthase activity

description: Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.


RNA-3'-phosphate cyclase activity

description: Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.


RNA-directed DNA polymerase activity

description: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.


RNA-dependent RNA polymerase activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.


RNA ligase (ATP) activity

description: Catalysis of the reaction: ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.


(S)-2-hydroxy-acid oxidase activity

description: Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose.


description: Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.


UDP-glucose 4-epimerase activity

description: Catalysis of the reaction: UDP-glucose = UDP-galactose.


UDP-glucose 6-dehydrogenase activity

description: Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate.


description: Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins.


description: Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose.


acetolactate synthase activity

description: Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.


acetyl-CoA C-acetyltransferase activity

description: Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.


acetyl-CoA hydrolase activity

description: Catalysis of the reaction: acetyl-CoA + H2O = acetate + CoA + H+.


acetate-CoA ligase activity

description: Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.


acetyl-CoA C-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.


acetyl-CoA carboxylase activity

description: Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.


acetylcholinesterase activity

description: Catalysis of the reaction: acetylcholine + H2O = choline + acetate.


acetylglutamate kinase activity

description: Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate.


description: Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.


acid phosphatase activity

description: Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.


aconitate hydratase activity

description: Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.


acyl-CoA dehydrogenase activity

description: Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].


acyl-CoA oxidase activity

description: Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.


acylphosphatase activity

description: Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.


description: Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.


adenosine deaminase activity

description: Catalysis of the reaction: adenosine + H2O = inosine + NH3.


adenosine kinase activity

description: Catalysis of the reaction: ATP + adenosine = ADP + AMP.


adenosylhomocysteinase activity

description: Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.


description: Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2.


description: Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate.


adenylate cyclase activity

description: Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.


adenylate kinase activity

description: Catalysis of the reaction: ATP + AMP = 2 ADP.


name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

description: Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.


adenylosuccinate synthase activity

description: Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate.


adenylylsulfate kinase activity

description: Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate.


description: Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.


alcohol dehydrogenase (NAD+) activity

description: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.


name: alcohol dehydrogenase (NAD+) activity, metal ion-independent

description: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion.


name: alcohol dehydrogenase (NAD+) activity, zinc-dependent

description: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.


name: alcohol dehydrogenase (NAD+) activity, iron-dependent

description: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron.


alcohol O-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester.


alcohol sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.


name: 3-chloroallyl aldehyde dehydrogenase activity

description: Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.


aldehyde dehydrogenase (NAD+) activity

description: Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.


name: aldehyde dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.


aldehyde oxidase activity

description: Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.


aldose reductase (NADPH) activity

description: Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.


aldo-keto reductase (NADPH) activity

description: Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.


aldose 1-epimerase activity

description: Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose.


alkaline phosphatase activity

description: Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.


allantoicase activity

description: Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea.


allantoinase activity

description: Catalysis of the reaction: allantoin + H2O = allantoate.


allophanate hydrolase activity

description: Catalysis of the reaction: H2O + 3 H+ + urea-1-carboxylate = 2 CO2 + 2 NH4.


amidase activity

description: Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.


description: Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+.


description: Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.


amidophosphoribosyltransferase activity

description: Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O.


aminoacyl-tRNA hydrolase activity

description: Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.


aminoacylase activity

description: Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid.


aminomethyltransferase activity

description: Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.


description: Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate.


anthranilate synthase activity

description: Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.


apyrase activity

description: Catalysis of the reaction: a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate. This reaction consists of two distinct successive phosphate-releasing steps, with NDPs as intermediates. Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs).


arachidonate 5-lipoxygenase activity

description: Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate.


description: Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.


arginase activity

description: Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.


arginine kinase activity

description: Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H+.


argininosuccinate synthase activity

description: Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.


argininosuccinate lyase activity

description: Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.


description: Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).


description: Catalysis of the reaction: L-amino acid + H+ = R-H + CO2.


description: Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine.


arylamine N-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.


arylformamidase activity

description: Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine.


aryl sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.


aryldialkylphosphatase activity

description: Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.


arylesterase activity

description: Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate.


arylsulfatase activity

description: Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate.


name: asparagine synthase (glutamine-hydrolyzing) activity

description: Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.


asparaginase activity

description: Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.


aspartate 1-decarboxylase activity

description: Catalysis of the reaction: L-aspartate = beta-alanine + CO2.


description: Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.


aspartate carbamoyltransferase activity

description: Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate.


aspartate-ammonia ligase activity

description: Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.


aspartate kinase activity

description: Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+.


description: Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP+ + phosphate = 4-phospho-L-aspartate + H+ + NADPH.


biliverdin reductase (NAD(P)H) activity

description: Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+.


biotin carboxylase activity

description: Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.


biotin synthase activity

description: Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+.


description: Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).


description: Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)).


description: Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase).


name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity

description: Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)).


description: Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate.


bisphosphoglycerate mutase activity

description: Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.


description: Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.


butyryl-CoA dehydrogenase activity

description: Catalysis of the reaction: butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].


name: carbamoyl-phosphate synthase (ammonia) activity

description: Catalysis of the reaction: 2 ATP + hydrogencarbonate + NH4+ = 2 ADP + carbamoyl phosphate + 2 H+ + phosphate.


name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

description: Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.


carbonate dehydratase activity

description: Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O.


carbonyl reductase (NADPH) activity

description: Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.


carnitine O-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA.


description: Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.


catalase activity

description: Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.


catechol oxidase activity

description: Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones.


cerebroside-sulfatase activity

description: Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate.


chitin deacetylase activity

description: Catalysis of the reaction: chitin + H2O = chitosan + acetate.


chitin synthase activity

description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1).


choline O-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.


choline kinase activity

description: Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+.


cholinesterase activity

description: Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.


description: Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline.


chorismate mutase activity

description: Catalysis of the reaction: chorismate = prephenate.


chorismate synthase activity

description: Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.


citrate (Si)-synthase activity

description: Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.


coproporphyrinogen oxidase activity

description: Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX.


description: Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al.


creatine kinase activity

description: Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+.


description: Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.


description: Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.


description: Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate.


description: Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+.


name: calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

description: Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.


name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity

description: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.


name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity

description: Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP.


name: photoreceptor cyclic-nucleotide phosphodiesterase activity

description: Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide.


cystathionine beta-synthase activity

description: Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.


cystathionine gamma-lyase activity

description: Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.


cysteine synthase activity

description: Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.


name: L-seryl-tRNA(Sec) selenium transferase activity

description: Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate.


cytidine deaminase activity

description: Catalysis of the reaction: cytidine + H+ + H2O = uridine + NH4 and deoxycytidine + H+ + H2O = deoxyuridine + NH4+.


(d)CMP kinase activity

description: Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.


name: cytochrome-b5 reductase activity, acting on NAD(P)H

description: Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).


cytochrome-c oxidase activity

description: Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.


cytochrome-c peroxidase activity

description: Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O.


cytosine deaminase activity

description: Catalysis of the reaction: cytosine + H2O = uracil + NH3.


dCMP deaminase activity

description: Catalysis of the reaction: dCMP + H2O = dUMP + NH3.


glycogen debranching enzyme activity

description: Catalysis of the cleavage of branch points in branched glycogen polymers.


4-alpha-glucanotransferase activity

description: Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.


amylo-alpha-1,6-glucosidase activity

description: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present.


deoxyadenosine kinase activity

description: Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+.


deoxycytidine kinase activity

description: Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.


deoxyguanosine kinase activity

description: Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H+.


deoxyribose-phosphate aldolase activity

description: Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.


dephospho-CoA kinase activity

description: Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+.


dethiobiotin synthase activity

description: Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 4 H+ + phosphate.


description: Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.


name: ATP-dependent diacylglycerol kinase activity

description: Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+.


description: Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.


diamine N-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.


dihydrofolate reductase activity

description: Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.


dihydrolipoyl dehydrogenase activity

description: Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.


description: Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.


dihydroneopterin aldolase activity

description: Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.


dihydroorotase activity

description: Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+.


dihydroorotate dehydrogenase activity

description: Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.


dihydropterin deaminase activity

description: Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3.


dihydropterin oxidase activity

description: Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide.


6,7-dihydropteridine reductase activity

description: Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine.


dihydropteroate synthase activity

description: Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.


dihydropyrimidinase activity

description: Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.


name: dihydropyrimidine dehydrogenase (NAD+) activity

description: Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+.


dihydroxy-acid dehydratase activity

description: Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.


dimethylallyltranstransferase activity

description: Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.


description: Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO2 + H+ + isopentenyl diphosphate + phosphate.


diphthine synthase activity

description: Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H+ + 3 S-adenosyl-L-homocysteine.


description: Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate.


dopachrome isomerase activity

description: Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.


dolichol kinase activity

description: Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate.


description: Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.


dUTP diphosphatase activity

description: Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate.


ecdysone O-acyltransferase activity

description: Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate.


description: Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein].


endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.


ATP-dependent peptidase activity

description: Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.


aminopeptidase activity

description: Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.


carboxypeptidase activity

description: Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain.


metallocarboxypeptidase activity

description: Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


serine-type carboxypeptidase activity

description: Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


aspartic-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.


cysteine-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


name: calcium-dependent cysteine-type endopeptidase activity

description: Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.


metalloendopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


name: initiator methionyl aminopeptidase activity

description: Catalysis of the release of N-terminal initiator methionine from peptides.


serine-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


threonine-type endopeptidase activity

description: Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.


enoyl-CoA hydratase activity

description: Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O.


epoxide hydrolase activity

description: Catalysis of the reaction: an epoxide + H2O = an ethanediol.


name: estradiol 17-beta-dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor.


estrone sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.


ethanolamine kinase activity

description: Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine.


description: Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.


ethanolaminephosphotransferase activity

description: Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.


exo-alpha-sialidase activity

description: Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.


exopolyphosphatase activity

description: Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.


description: Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.


farnesyltranstransferase activity

description: Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.


fatty acid synthase activity

description: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.


description: Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein].


description: Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein].


description: Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein].


name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity

description: Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+.


description: Catalysis of the reaction: (3R)-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O.


name: enoyl-[acyl-carrier-protein] reductase (NADH) activity

description: Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH.


fatty-acyl-CoA synthase activity

description: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.


ferroxidase activity

description: Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.


ferredoxin-NADP+ reductase activity

description: Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+.


ferrochelatase activity

description: Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX.


description: Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).


formamidase activity

description: Catalysis of the reaction: formamide + H2O = formate + NH4.


description: Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.


description: Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.


fructose-bisphosphate aldolase activity

description: Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.


fumarate hydratase activity

description: Catalysis of the reaction: (S)-malate = fumarate + H2O.


fumarylacetoacetase activity

description: Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+.


galactokinase activity

description: Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+.


galactosylceramidase activity

description: Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.


geranyltranstransferase activity

description: Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.


description: Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.


glucan 1,4-alpha-glucosidase activity

description: Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.


glucokinase activity

description: Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.


gluconolactonase activity

description: Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.


description: Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4.


name: glucosamine 6-phosphate N-acetyltransferase activity

description: Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+.


glucose dehydrogenase activity

description: Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor.


description: Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.


glucose-6-phosphatase activity

description: Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate.


glucose-6-phosphate isomerase activity

description: Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.


glucosylceramidase activity

description: Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.


glutamate 5-kinase activity

description: Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+.


description: Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH.


glutamate decarboxylase activity

description: Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.


glutamate dehydrogenase (NAD+) activity

description: Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.


name: glutamate dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.


name: glutamate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.


glutamate synthase (NADPH) activity

description: Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+.


glutamine synthetase activity

description: Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate.


glutamate-cysteine ligase activity

description: Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate.


glutamate N-acetyltransferase activity

description: Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine.


glutaminase activity

description: Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.


name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity

description: Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.


glutaryl-CoA dehydrogenase activity

description: Catalysis of the reaction: glutaryl-CoA + 2 H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein].


name: glutathione-disulfide reductase (NADPH) activity

description: Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.


glutathione synthase activity

description: Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate.


glutathione transferase activity

description: Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.


name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

description: Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.


description: Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.


name: glycerol-3-phosphate dehydrogenase (quinone) activity

description: Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.


glycerol-3-phosphate oxidase activity

description: Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2.


glycerol kinase activity

description: Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+.


glycerone kinase activity

description: Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+.


description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.


glycogen (starch) synthase activity

description: Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1).


name: glycine dehydrogenase (decarboxylating) activity

description: Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.


glycolipid mannosyltransferase activity

description: Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage.


description: Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.


description: Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage.


description: Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.


description: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.


description: Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.


GDP phosphatase activity

description: Catalysis of the reaction: GDP + H2O = GMP + phosphate.


guanylate cyclase activity

description: Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.


guanylate kinase activity

description: Catalysis of the reaction: ATP + GMP = ADP + GDP.


helicase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.


heme oxygenase (decyclizing) activity

description: Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase].


name: heparan sulfate 2-O-sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate.


hexokinase activity

description: Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.


histidine ammonia-lyase activity

description: Catalysis of the reaction: L-histidine = urocanate + NH3.


histidine decarboxylase activity

description: Catalysis of the reaction: L-histidine = histamine + CO2.


histidinol dehydrogenase activity

description: Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+.


description: Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.


histidinol-phosphatase activity

description: Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate.


histone acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.


histone deacetylase activity

description: Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.


holocytochrome-c synthase activity

description: Catalysis of the reaction: holocytochrome c = apocytochrome c + heme.


homoaconitate hydratase activity

description: Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O.


homocitrate synthase activity

description: Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate.


homogentisate 1,2-dioxygenase activity

description: Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+.


homoserine dehydrogenase activity

description: Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+.


homoserine kinase activity

description: Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+.


homoserine O-acetyltransferase activity

description: Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA.


hyalurononglucosaminidase activity

description: Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.


description: Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.


hydroxyethylthiazole kinase activity

description: Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H+.


hydroxymethylbilane synthase activity

description: Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4.


description: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.


name: hydroxymethylglutaryl-CoA reductase (NADPH) activity

description: Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH.


description: Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+.


description: Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.


iduronate-2-sulfatase activity

description: Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.


description: Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.


description: Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O.


name: inorganic diphosphate phosphatase activity

description: Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+.


name: phosphatidylinositol phospholipase C activity

description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.


description: Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.


description: Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.


description: Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.


iodide peroxidase activity

description: Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O.


name: isocitrate dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H.


name: isocitrate dehydrogenase (NAD+) activity

description: Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.


name: isocitrate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.


isocitrate lyase activity

description: Catalysis of the reaction: isocitrate = glyoxylate + succinate.


description: Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate.


juvenile-hormone esterase activity

description: Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone.


ketohexokinase activity

description: Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate.


ketol-acid reductoisomerase activity

description: Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.


phosphogluconate dehydratase activity

description: Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O.


lactate dehydrogenase activity

description: Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate.


name: D-lactate dehydrogenase (cytochrome) activity

description: Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.


L-lactate dehydrogenase activity

description: Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.


name: L-lactate dehydrogenase (cytochrome) activity

description: Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.


lactose synthase activity

description: Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose.


lactoylglutathione lyase activity

description: Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.


leukotriene-A4 hydrolase activity

description: Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4).


leukotriene-C4 synthase activity

description: Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4).


lipoprotein lipase activity

description: Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein.


name: long-chain fatty acyl-CoA dehydrogenase activity

description: Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


name: long-chain fatty acid-CoA ligase activity

description: Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


name: lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

description: Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.


malic enzyme activity

description: Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.


name: malate dehydrogenase (decarboxylating) (NAD+) activity

description: Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.


name: malate dehydrogenase (decarboxylating) (NADP+) activity

description: Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.


malate synthase activity

description: Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+.


name: mannose-1-phosphate guanylyltransferase (GTP) activity

description: Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.


mannose-6-phosphate isomerase activity

description: Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.


description: Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.


methionine adenosyltransferase activity

description: Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.


description: Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.


description: Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid.


name: mRNA 5'-cap (guanine-N7-)-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.


description: Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.


mRNA guanylyltransferase activity

description: Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue.


description: Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate.


name: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.


name: methylenetetrahydrofolate dehydrogenase (NAD+) activity

description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.


name: methylenetetrahydrofolate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.


name: methylenetetrahydrofolate reductase (NAD(P)H) activity

description: Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.


methylglutaconyl-CoA hydratase activity

description: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O.


name: methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity

description: Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.


name: methyl/ethyl malonyl-CoA decarboxylase activity

description: Catalysis of the reaction: (S)-methylmalonyl-CoA + H+ = CO2 + propanoyl-CoA or (2S)-ethylmalonyl-CoA + H+ = butanoyl-CoA + CO2.


methylmalonyl-CoA epimerase activity

description: Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.


methylmalonyl-CoA mutase activity

description: Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA.


mevalonate kinase activity

description: Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H+.


monooxygenase activity

description: Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.


calcidiol 1-monooxygenase activity

description: Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+.


description: Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.


dopamine beta-monooxygenase activity

description: Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O.


ecdysone 20-monooxygenase activity

description: Catalysis of the reaction: AH(2) + Ecdysone + O2 = 20-hydroxyecdysone + A + H2O.


kynurenine 3-monooxygenase activity

description: Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+.


tyrosinase activity

description: Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates.


peptidylglycine monooxygenase activity

description: Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O.


phenylalanine 4-monooxygenase activity

description: Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.


squalene monooxygenase activity

description: Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+.


steroid 11-beta-monooxygenase activity

description: Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.


steroid 17-alpha-monooxygenase activity

description: Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


steroid 21-monooxygenase activity

description: Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O.


tryptophan 5-monooxygenase activity

description: Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.


tyrosine 3-monooxygenase activity

description: Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O.


inositol-3-phosphate synthase activity

description: Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.


name: nicotinate-nucleotide diphosphorylase (carboxylating) activity

description: Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate.


description: Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+.


description: Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate.


nitric-oxide synthase activity

description: Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.


nuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids.


endonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.


DNA endonuclease activity

description: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.


RNA endonuclease activity

description: Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.


ribonuclease A activity

description: Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.


RNA-DNA hybrid ribonuclease activity

description: Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.


ribonuclease III activity

description: Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.


ribonuclease P activity

description: Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.


exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.


phosphodiesterase I activity

description: Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.


DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.


deoxyribonuclease I activity

description: Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products.


deoxyribonuclease II activity

description: Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products.


RNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.


exoribonuclease H activity

description: Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions.


5'-3' RNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule.


poly(A)-specific ribonuclease activity

description: Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.


DNA nuclease activity

description: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.


RNA nuclease activity

description: Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.


tRNA-specific ribonuclease activity

description: Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.


nucleoside diphosphate kinase activity

description: Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.


dinucleotide phosphatase activity

description: Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides.


octanol dehydrogenase (NAD+) activity

description: Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + H+ + NADH.


name: hydrolase activity, hydrolyzing O-glycosyl compounds

description: Catalysis of the hydrolysis of any O-glycosyl bond.


alpha,alpha-trehalase activity

description: Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose.


alpha-amylase activity

description: Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.


alpha-galactosidase activity

description: Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.


alpha-1,4-glucosidase activity

description: Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.


alpha-mannosidase activity

description: Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.


alpha-L-fucosidase activity

description: Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose.


alpha-N-acetylglucosaminidase activity

description: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.


beta-N-acetylhexosaminidase activity

description: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.


beta-fructofuranosidase activity

description: Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside.


beta-galactosidase activity

description: Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.


beta-glucuronidase activity

description: Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.


beta-mannosidase activity

description: Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.


chitinase activity

description: Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins.


description: Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane.


description: Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.


description: Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).


name: Glc3Man9GlcNAc2 oligosaccharide glucosidase activity

description: Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).


oligo-1,6-glucosidase activity

description: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose.


sucrose alpha-glucosidase activity

description: Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose.


oligosaccharyl transferase activity

description: Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol.


description: Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol.


description: Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.


description: Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate.


description: Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.


description: Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide.


ornithine carbamoyltransferase activity

description: Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.


ornithine decarboxylase activity

description: Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine.


ornithine aminotransferase activity

description: Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde.


description: Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.


name: dihydroorotate dehydrogenase (NAD+) activity

description: Catalysis of the reaction: (S)-dihydroorotate + NAD+ = H+ + NADH + orotate.


description: Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP.


name: oxoglutarate dehydrogenase (succinyl-transferring) activity

description: Catalysis of the reaction: 2-oxoglutarate + lipoamide + H+ = S-succinyldihydrolipoamide + CO2.


pantoate-beta-alanine ligase activity

description: Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.


pantothenase activity

description: Catalysis of the reaction: (R)-pantothenate + H2O = (R)-pantoate + beta-alanine.


pantothenate kinase activity

description: Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.


description: Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate.


description: Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.


peptidylamidoglycolate lyase activity

description: Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate.


peroxidase activity

description: Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.


glutathione peroxidase activity

description: Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.


description: Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.


name: phosphoadenylyl-sulfate reductase (thioredoxin) activity

description: Catalysis of the reaction: adenosine 3',5'-diphosphate + H+ + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS.


description: Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.


description: Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine.


description: Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H+ + phosphatidyl-N-methylethanolamine.


description: Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine.


description: Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.


description: Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products.


name: phosphoenolpyruvate carboxykinase (ATP) activity

description: Catalysis of the reaction: ATP + oxaloacetate = ADP + CO2 + H+ + phosphoenolpyruvate.


name: phosphoenolpyruvate carboxykinase (GTP) activity

description: Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.


phosphoglucomutase activity

description: Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.


phosphomannomutase activity

description: Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.


name: phosphogluconate dehydrogenase (decarboxylating) activity

description: Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.


phosphoglycerate dehydrogenase activity

description: Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.


phosphoglycerate kinase activity

description: Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+.


phosphoglycerate mutase activity

description: Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.


phospholipase activity

description: Catalysis of the hydrolysis of a glycerophospholipid.


name: glycosylphosphatidylinositol phospholipase D activity

description: Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.


lysophospholipase activity

description: Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.


phospholipase A2 activity

description: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.


phospholipase C activity

description: Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.


phospholipase D activity

description: Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.


phosphomevalonate kinase activity

description: Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H+.


description: Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives.


description: Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H+ = CO2 + pantetheine 4'-phosphate.


phosphopyruvate hydratase activity

description: Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.


description: Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide.


description: Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+.


description: Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate.


description: Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.


description: Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate.


description: Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.


description: Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate.


description: Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate.


description: Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide.


description: Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.


description: Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase.


description: Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.


description: Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.


polygalacturonase activity

description: Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans.


polynucleotide 5'-phosphatase activity

description: Catalysis of the reaction: a 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate.


description: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.


description: Catalysis of the reaction: RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.


porphobilinogen synthase activity

description: Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen.


description: Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.


proline dehydrogenase activity

description: Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.


propionyl-CoA carboxylase activity

description: Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.


prenyltransferase activity

description: Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).


protein farnesyltransferase activity

description: Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.


description: Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.


description: Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.


Rab geranylgeranyltransferase activity

description: Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.


prephenate dehydratase activity

description: Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2.


name: prephenate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADPH.


description: Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.


prostaglandin-D synthase activity

description: Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).


protein-arginine deiminase activity

description: Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent.


name: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.


protein kinase activity

description: Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.


protein histidine kinase activity

description: Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.


name: protein serine/threonine kinase activity

description: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


name: transmembrane receptor protein serine/threonine kinase activity

description: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


name: 3-phosphoinositide-dependent protein kinase activity

description: Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


DNA-dependent protein kinase activity

description: DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


AMP-activated protein kinase activity

description: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.


name: calmodulin-dependent protein kinase activity

description: Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.


elongation factor-2 kinase activity

description: Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate.


myosin light chain kinase activity

description: Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.


phosphorylase kinase activity

description: Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.


name: cyclic nucleotide-dependent protein kinase activity

description: cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


cAMP-dependent protein kinase activity

description: cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


cGMP-dependent protein kinase activity

description: cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


name: cyclin-dependent protein serine/threonine kinase activity

description: Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


name: eukaryotic translation initiation factor 2alpha kinase activity

description: Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate.


name: diacylglycerol-dependent serine/threonine kinase activity

description: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.


name: calcium,diacylglycerol-dependent serine/threonine kinase activity

description: Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


name: diacylglycerol-dependent, calcium-independent serine/threonine kinase activity

description: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.


name: G protein-coupled receptor kinase activity

description: Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.


JUN kinase activity

description: Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors.


JUN kinase kinase kinase activity

description: Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).


MAP kinase activity

description: Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.


MAP kinase kinase activity

description: Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a T-X-Y motif in the activation loop of a MAP kinase (MAPK) substrate.


MAP kinase kinase kinase activity

description: Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.


ribosomal protein S6 kinase activity

description: Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.


name: protein serine/threonine/tyrosine kinase activity

description: Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.


protein tyrosine kinase activity

description: Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.


name: transmembrane receptor protein tyrosine kinase activity

description: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.


name: non-membrane spanning protein tyrosine kinase activity

description: Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.


name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.


protein-lysine 6-oxidase activity

description: Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide.


phosphoprotein phosphatase activity

description: Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.


name: protein serine/threonine phosphatase activity

description: Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.


name: calcium-dependent protein serine/threonine phosphatase activity

description: Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.


protein tyrosine phosphatase activity

description: Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


name: non-membrane spanning protein tyrosine phosphatase activity

description: Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.


name: prenylated protein tyrosine phosphatase activity

description: Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate.


name: oxygen-dependent protoporphyrinogen oxidase activity

description: Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX.


pseudouridylate synthase activity

description: Catalysis of the reaction: D-ribose 5-phosphate + uracil = H2O + pseudouridine 5'-phosphate.


description: Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.


pyridoxal oxidase activity

description: Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide.


pyridoxamine phosphate oxidase activity

description: Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + hydrogen peroxide.


pyrimidodiazepine synthase activity

description: Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione.


description: Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.


pyruvate carboxylase activity

description: Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate.


pyruvate decarboxylase activity

description: Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2.


pyruvate dehydrogenase activity

description: Catalysis of the oxidative decarboxylation of pyruvate.


name: pyruvate dehydrogenase (acetyl-transferring) activity

description: Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.


name: pyruvate dehydrogenase (acetyl-transferring) kinase activity

description: Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.


name: [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

description: Catalysis of the reaction: O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate.


description: Catalysis of the reaction: (R)-N6-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA.


pyruvate kinase activity

description: Catalysis of the reaction: = ADP + H+ + phosphoenolpyruvate => ATP + pyruvate.


name: all-trans-retinol dehydrogenase (NAD+) activity

description: Catalysis of the reaction: all-trans-retinol--[retinol-binding protein] + NAD+ = all-trans-retinal--[retinol-binding protein] + H+ + NADH. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.


riboflavin synthase activity

description: Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin.


ribokinase activity

description: Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate.


name: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

description: Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


name: ribose phosphate diphosphokinase activity

description: Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+.


description: Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate.


ribose-5-phosphate isomerase activity

description: Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate.


saccharopine dehydrogenase activity

description: Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor.


name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity

description: Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH.


name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity

description: Catalysis of the reaction: L-saccharopine + H2O + NADP+ = L-allysine + L-glutamate + H+ + NADPH.


selenide, water dikinase activity

description: Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate.


sepiapterin reductase (NADP+) activity

description: Catalysis of the reactions: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H+ + 2 NADPH.


serine C-palmitoyltransferase activity

description: Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA.


serine-pyruvate transaminase activity

description: Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.


name: shikimate 3-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.


shikimate kinase activity

description: Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H+.


spermidine synthase activity

description: Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine.


description: Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.


stearoyl-CoA 9-desaturase activity

description: Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O.


steroid delta-isomerase activity

description: Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid.


sterol esterase activity

description: Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid.


sterol O-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester.


steryl-sulfatase activity

description: Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.


succinate-CoA ligase activity

description: Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA.


name: succinate-CoA ligase (ADP-forming) activity

description: Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate.


name: succinate-CoA ligase (GDP-forming) activity

description: Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.


name: succinate-semialdehyde dehydrogenase (NAD+) activity

description: Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+.


succinyl-CoA hydrolase activity

description: Catalysis of the reaction: H2O + succinyl-CoA = CoA + H+ + succinate.


sulfate adenylyltransferase activity

description: Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate.


name: sulfate adenylyltransferase (ADP) activity

description: Catalysis of the reaction: ADP + H+ + sulfate = 5'-adenylyl sulfate + phosphate.


name: sulfate adenylyltransferase (ATP) activity

description: Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate.


sulfinoalanine decarboxylase activity

description: Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2.


sulfite reductase (NADPH) activity

description: Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+.


superoxide dismutase activity

description: Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.


name: thiamine diphosphate phosphatase activity

description: Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate.


thiamine diphosphokinase activity

description: Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate.


description: Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H+ = diphosphate + thiamine phosphate.


thioether S-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.


name: thioredoxin-disulfide reductase (NADPH) activity

description: Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH.


thiosulfate sulfurtransferase activity

description: Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate.


threonine aldolase activity

description: Catalysis of the reaction: L-threonine = glycine + acetaldehyde.


threonine deaminase activity

description: Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4.


threonine synthase activity

description: Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate.


thromboxane-A synthase activity

description: Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2).


thymidine kinase activity

description: Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.


thymidylate kinase activity

description: Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.


thymidylate synthase activity

description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.


thyroxine 5'-deiodinase activity

description: Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2.


transaldolase activity

description: Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.


transketolase activity

description: Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.


transposase activity

description: Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.


trehalose-phosphatase activity

description: Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate.


triglyceride lipase activity

description: Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.


triose-phosphate isomerase activity

description: Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.


description: Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate.


name: CCA tRNA nucleotidyltransferase activity

description: Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate.


aminoacyl-tRNA ligase activity

description: Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.


alanine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).


arginine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).


aspartate-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).


asparagine-tRNA ligase activity

description: Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H+.


cysteine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).