name: negative regulation of calcium-dependent cell-cell adhesion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion.


ribonuclease T1 activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates.


polyamine oxidase activity

description: Catalysis of the oxidative degradation or interconversion of polyamines.


mandelonitrile lyase activity

description: Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde.


maintenance of pole plasm mRNA location

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster.


name: establishment of pole plasm mRNA localization

description: Any process that results in the directed movement of mRNA to the oocyte pole plasm.


name: regulation of viral entry into host cell

description: Any process that modulates the frequency, rate or extent of the viral entry into the host cell.


name: negative regulation of viral entry into host cell

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell.


name: positive regulation of viral entry into host cell

description: Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell.


regulation of centriole replication

description: Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole.


name: negative regulation of centriole replication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication.


name: positive regulation of centriole replication

description: Any process that activates or increases the frequency, rate or extent of centriole replication.


name: regulation of mitotic centrosome separation

description: Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis.


name: negative regulation of mitotic centrosome separation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of centrosome separation.


name: positive regulation of mitotic centrosome separation

description: Any process that activates or increases the frequency, rate or extent of centrosome separation.


regulation of centrosome cycle

description: Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation.


negative regulation of centrosome cycle

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the centrosome cycle.


positive regulation of centrosome cycle

description: Any process that activates or increases the frequency, rate or extent of the centrosome cycle.


carotenoid isomerase activity

description: Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids.


name: lysosomal proton-transporting V-type ATPase, V0 domain

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.


name: lysosomal proton-transporting V-type ATPase complex

description: A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen.


name: lysosomal proton-transporting V-type ATPase, V1 domain

description: The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane.


xenobiotic export from cell

description: The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


name: lens placode formation involved in camera-type eye formation

description: Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles.


regulation of organ growth

description: Any process that modulates the frequency, rate or extent of growth of an organ of an organism.


negative regulation of organ growth

description: Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.


positive regulation of organ growth

description: Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.


sphingolipid floppase activity

description: Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


sphingolipid transporter activity

description: Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


sphingolipid binding

description: Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


name: regulation of insulin receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of insulin receptor signaling.


name: negative regulation of insulin receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.


name: positive regulation of insulin receptor signaling pathway

description: Any process that increases the frequency, rate or extent of insulin receptor signaling.


gamma-delta T cell activation

description: The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


gamma-delta T cell proliferation

description: The expansion of a gamma-delta T cell population by cell division.


alpha-beta T cell activation

description: The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


alpha-beta T cell differentiation

description: The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex.


alpha-beta T cell proliferation

description: The expansion of an alpha-beta T cell population by cell division.


name: regulation of alpha-beta T cell activation

description: Any process that modulates the frequency, rate or extent of alpha-beta T cell activation.


name: positive regulation of alpha-beta T cell activation

description: Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation.


name: negative regulation of alpha-beta T cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.


name: regulation of alpha-beta T cell differentiation

description: Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation.


name: positive regulation of alpha-beta T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.


name: negative regulation of alpha-beta T cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation.


name: regulation of alpha-beta T cell proliferation

description: Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation.


name: positive regulation of alpha-beta T cell proliferation

description: Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.


name: negative regulation of alpha-beta T cell proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation.


name: regulation of gamma-delta T cell activation

description: Any process that modulates the frequency, rate or extent of gamma-delta T cell activation.


name: negative regulation of gamma-delta T cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation.


name: positive regulation of gamma-delta T cell activation

description: Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation.


name: regulation of gamma-delta T cell proliferation

description: Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation.


name: negative regulation of gamma-delta T cell proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation.


name: positive regulation of gamma-delta T cell proliferation

description: Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation.


lymphocyte activation

description: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.


lymphocyte proliferation

description: The expansion of a lymphocyte population by cell division.


tetrahydrofolate metabolic process

description: The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.


tetrahydrofolate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.


folic acid metabolic process

description: The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.


folic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid.


folic acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid.


digestive hormone activity

description: The action characteristic of a hormone that takes part in the digestion process.


female sex differentiation

description: The establishment of the sex of a female organism by physical differentiation.


male sex differentiation

description: The establishment of the sex of a male organism by physical differentiation.


regulation of egg-laying behavior

description: Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium.


name: dorsal closure, leading edge cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure.


name: dorsal closure, amnioserosa morphology change

description: The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo.


amnioserosa maintenance

description: Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis.


retinal cell programmed cell death

description: Programmed cell death that occurs in the developing retina.


name: compound eye retinal cell programmed cell death

description: Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium.


name: regulation of retinal cell programmed cell death

description: Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina.


name: regulation of compound eye retinal cell programmed cell death

description: Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.


name: positive regulation of retinal cell programmed cell death

description: Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina.


name: negative regulation of retinal cell programmed cell death

description: Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina.


name: positive regulation of compound eye retinal cell programmed cell death

description: Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.


name: negative regulation of compound eye retinal cell programmed cell death

description: Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.


name: negative regulation of insulin secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.


response to antibiotic

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.


response to bacteriocin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation.


response to streptomycin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome.


response to DDT

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals.


response to carbamate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase.


response to cyclodiene

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring.


response to organophosphorus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors.


response to pyrethroid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage.


name: response to arsenic-containing substance

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.


response to cadmium ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.


response to chromate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus.


response to copper ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.


response to mercury ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.


response to tellurium ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus.


intracellular canaliculus

description: An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates.


sperm competition

description: Any process that contributes to the success of sperm fertilization in multiply-mated females.


sperm storage

description: The retention of sperm by a female following mating.


sperm incapacitation

description: The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males.


SLIK (SAGA-like) complex

description: A SAGA-type histone acetyltransferase complex that contains a smaller form of Spt7 (lacking the SPT8 binding region) than the fungal SAGA complex, and consequently lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction.


lipopolysaccharide receptor complex

description: A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens.


decidualization

description: The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.


insecticide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects.


description: Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside.


name: natural killer cell lectin-like receptor binding

description: Binding to a lectin-like natural killer cell receptor.


CDP metabolic process

description: The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate.


CDP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate.


CDP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate.


IDP metabolic process

description: The chemical reactions and pathways involving IDP, inosine 5'-diphosphate.


IDP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate.


IDP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate.


GDP metabolic process

description: The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate.


GDP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate.


GDP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate.


borate transport

description: The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals.


borate binding

description: Binding to borate, the anion (BO3)3-.


name: active borate transmembrane transporter activity

description: Enables the transport of borate across a membrane against the concentration gradient.


muscle cell cellular homeostasis

description: The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.


acid secretion

description: The controlled release of acid by a cell or a tissue.


symbiont entry into host cell

description: The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell.


name: regulation by virus of viral protein levels in host cell

description: Any virus-mediated process that modulates the levels of viral proteins in a cell.


citric acid secretion

description: The controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or a tissue.


formic acid secretion

description: The controlled release of formic acid, HCOOH, by a cell or a tissue.


lactic acid secretion

description: The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue.


malic acid secretion

description: The controlled release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or a tissue.


oxalic acid secretion

description: The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue.


name: negative regulation by virus of viral protein levels in host cell

description: Any process where the infecting virus reduces the levels of viral proteins in a cell.


name: positive regulation by virus of viral protein levels in host cell

description: Any process where the infecting virus increases the levels of viral proteins in a cell.


capsomere

description: Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses.


viral procapsid

description: A stable empty viral capsid produced during the assembly of viruses.


name: transport of virus in multicellular host

description: The transport of a virus between cells in a multicellular organism. The cells can be adjacent or spatially separated (e.g. in different tissues or organs).


name: transport of virus in host, cell to cell

description: The transport of a virus between adjacent cells in a multicellular organism.


name: transport of virus in host, tissue to tissue

description: The transport of a virus between tissues in a multicellular organism.


viral capsid secondary envelopment

description: The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope.


non-lytic viral release

description: The exit of a viral particle from a host cell that does not involve cell lysis.


viral exocytosis

description: The exit of a fully formed virion particles from the host cell by exocytosis via a host vesicle.


viral budding

description: A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space.


viral budding from Golgi membrane

description: A viral budding that starts with formation of a membrane curvature in the host Golgi membrane.


viral budding from plasma membrane

description: A viral budding that starts with formation of a curvature in the host plasma membrane around which the virion particle assembles.


name: viral budding from endoplasmic reticulum membrane

description: A viral budding that starts with formation of a membrane curvature in the host ER membrane.


viral budding from nuclear membrane

description: A viral budding that starts with formation of a membrane curvature in the host nuclear membrane.


name: viral budding from inner nuclear membrane

description: The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system into the perinuclear space, thus acquiring a membrane envelope.


name: viral budding from outer nuclear membrane

description: The envelopment of a virus, in which the naked capsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope.


name: symbiont-mediated suppression of host translation termination

description: A process in which a symbiont inhibits or disrupts translation termination of host mRNAs. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: suppression by virus of host intracellular interferon activity

description: Any viral process that results in the inhibition of interferon activity within the host cell.


name: suppression by virus of host cytokine production

description: Any viral process that results in the inhibition of host cell cytokine production.


name: symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I

description: A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, some viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response.


protein autophosphorylation

description: The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).


name: symbiont-mediated suppression of host mRNA splicing

description: A process in which a symbiont inhibits or disrupts the splicing of host mRNA, thus interfering with normal host protein production. The host is defined as the larger of the organisms involved in a symbiotic interaction.


regulation of viral transcription

description: Any process that modulates the frequency, rate or extent of the transcription of the viral genome.


name: viral mRNA export from host cell nucleus

description: The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation.


microtubule polymerization

description: The addition of tubulin heterodimers to one or both ends of a microtubule.


name: viral replication complex formation and maintenance

description: The process of organizing and assembling viral replication proteins in preparation for viral replication.


viral DNA repair

description: The process of restoring viral DNA after damage or errors in replication.


host cell surface receptor binding

description: Binding to a receptor on the host cell surface.


virion binding

description: Binding to a virion, either by binding to components of the capsid or the viral envelope.


transport of virus

description: The directed movement of a virus, or part of a virus, into, out of, or within a host cell.


viral procapsid maturation

description: The refolding and structural rearrangements of individual capsid subunits to transition from the intermediate procapsid, to the more stable capsid structure.


viral portal complex

description: A multimeric ring of proteins through which the DNA enters and exits the viral capsid.


name: exit of virus from host cell nucleus by nuclear egress

description: The directed movement of an assembled viral particle out of the host cell nucleus by budding and fusion through the nuclear membranes. In this process, enveloped viral particles are formed by budding through the inner nuclear membrane. These perinuclear enveloped particles then fuse with the outer nuclear membrane to deliver a naked capsid into the host cytoplasm.


protein-heme linkage via 1'-L-histidine

description: The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine).


viral scaffold

description: A complex of proteins that form a scaffold around which the viral capsid is constructed.


viral scaffold assembly and maintenance

description: The assembly and maintenance of the viral scaffold around which the viral capsid is constructed.


replication compartment

description: Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously.


host cell extracellular matrix binding

description: Binding to the extracellular matrix of a host cell.


histone deacetylase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes.


host cell surface binding

description: Binding to the surface of a host cell.


name: receptor-mediated virion attachment to host cell

description: The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface.


name: coreceptor-mediated virion attachment to host cell

description: The process by which a virion attaches to a host cell by binding to a co-receptor on the host cell surface.


virion transport vesicle

description: A vesicle used to transport the partial or complete virion between cellular compartments.


chemokine receptor antagonist activity

description: Interacts with chemokine receptors to reduce the action of a chemokine.


dense nuclear body

description: A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously.


name: protein secretion by the type V secretion system

description: The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway.


description: Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate.


extrachromosomal DNA

description: DNA structures that are not part of a chromosome.


name: regulation of nucleocytoplasmic transport

description: Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.


name: negative regulation of nucleocytoplasmic transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.


name: positive regulation of nucleocytoplasmic transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.


name: regulation of protein export from nucleus

description: Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm.


name: negative regulation of protein export from nucleus

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.


name: positive regulation of protein export from nucleus

description: Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.


regulation of RNA import into nucleus

description: Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus.


name: negative regulation of RNA import into nucleus

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus.


name: positive regulation of RNA import into nucleus

description: Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus.


regulation of RNA export from nucleus

description: Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm.


name: negative regulation of RNA export from nucleus

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm.


name: positive regulation of RNA export from nucleus

description: Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm.


lipid phosphorylation

description: The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.


carbohydrate phosphorylation

description: The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.


glycolipid transport

description: The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


phospholipid dephosphorylation

description: The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.


trisporic acid metabolic process

description: The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota.


trisporic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of trisporic acid.


dorsal appendage formation

description: Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration.


chorion micropyle formation

description: Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization.


name: branched duct epithelial cell fate determination, open tracheal system

description: Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode.


filopodium assembly

description: The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.


hydroxyapatite binding

description: Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin.


bone remodeling

description: The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.


regulation of bone remodeling

description: Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.


negative regulation of bone remodeling

description: Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.


positive regulation of bone remodeling

description: Any process that activates or increases the frequency, rate or extent of bone remodeling.


name: phosphatidylinositol phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.


phosphatidylinositol dephosphorylation

description: The process of removing one or more phosphate groups from a phosphatidylinositol.


name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP.


chlorosome

description: A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate.


hydrogenosomal membrane

description: The lipid bilayer surrounding a hydrogenosome.


glycosome membrane

description: The lipid bilayer surrounding a glycosome.


glyoxysomal membrane

description: The lipid bilayer surrounding a glyoxysome.


chromoplast membrane

description: Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope.


name: ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity

description: Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate.


isoprenoid transport

description: The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


terpenoid transport

description: The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups.


tetraterpenoid transport

description: The directed movement of tetraterpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetraterpenoids are terpenoids with eight isoprene units.


carotenoid transport

description: The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail.


mesosome

description: An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins.


name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide

description: The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide.


cadmium ion binding

description: Binding to a cadmium ion (Cd).


N-acetylgalactosamine binding

description: Binding to N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine.


metal ion binding

description: Binding to a metal ion.


name: metal ion transmembrane transporter activity

description: Enables the transfer of metal ions from one side of a membrane to the other.


quinolinate metabolic process

description: The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.


ephrin receptor binding

description: Binding to an ephrin receptor.


3,4-didehydroretinal binding

description: Binding to 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod).


regulation of saliva secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue.


positive regulation of saliva secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of saliva.


hormone secretion

description: The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.


name: regulation of follicle-stimulating hormone secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone.


name: positive regulation of follicle-stimulating hormone secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone.


name: negative regulation of follicle-stimulating hormone secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone.


regulation of hormone secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.


follicle-stimulating hormone secretion

description: The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary.


name: regulation of hormone biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.


name: positive regulation of hormone biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.


name: positive regulation of hormone secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.


name: negative regulation of hormone secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.


name: positive regulation of lipid biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.


name: regulation of lipid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.


peptidyl-cysteine S-carbamoylation

description: The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine.


description: The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine.


name: iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation

description: The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase.


description: The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine.


N-terminal peptidyl-leucine methylation

description: The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine.


description: The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine.


response to cycloheximide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes.


name: nucleoside triphosphate adenylate kinase activity

description: Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP.


description: The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.


description: The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues.


name: regulation of mitochondrial membrane permeability

description: Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.


secretion

description: The controlled release of a substance by a cell or a tissue.


calcium oxalate binding

description: Binding to calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi.


15-cis-phytoene synthase activity

description: Catalysis of the reaction: 2 geranylgeranyl diphosphate -> 15-cis-phytoene + 2 diphosphate.


tetrapyrrole binding

description: Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position.


intracellular transport

description: The directed movement of substances within a cell.


pectinesterase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of pectinesterase.


metal chelating activity

description: The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring.


name: acyltransferase activity, acyl groups converted into alkyl on transfer

description: Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.


transition metal ion binding

description: Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.


name: transition metal ion transmembrane transporter activity

description: Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.


description: Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine.


description: The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine.


pyruvyltransferase activity

description: Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another.


description: Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage.


description: Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage.


peptide-O-fucosyltransferase activity

description: Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.


ER retention sequence binding

description: Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.


name: peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine

description: The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine.


name: peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine

description: The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine.


name: peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine

description: The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine.


peptidyl-threonine racemization

description: The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine.


name: regulation of neurotransmitter secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.


name: negative regulation of neurotransmitter secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.


pore complex

description: A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids.


pore complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases.


name: sodium-transporting ATP synthase activity, rotational mechanism

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism.


name: proton-transporting ATP synthase activity, rotational mechanism

description: Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out).


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+.


description: Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.


2'-deoxyadenosine deaminase activity

description: Catalysis of the reaction: 2'-deoxyadenosine + H2O = deoxyinosine + NH3.


phytochelatin metabolic process

description: The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11.


phytochelatin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11.


description: The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside.


name: azetidine-2-carboxylic acid acetyltransferase activity

description: Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid.


carboxylic acid transport

description: The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).


name: carboxylic acid transmembrane transporter activity

description: Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).


protein carbamoylation

description: The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2.


description: The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine.


hydroxylysine metabolic process

description: The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases.


hydroxylysine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid.


hydroxylysine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid.


fatty-acyl-CoA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.


cellular ketone body metabolic process

description: The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.


ketone body biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.


ketone body catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA.


positive phototaxis

description: The directed movement of a cell or organism towards a source of light.


negative phototaxis

description: The directed movement of a cell or organism away from a source of light.


nonassociative learning

description: A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment.


habituation

description: A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented.


sensitization

description: An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched.


name: proton-transporting ATPase activity, rotational mechanism

description: Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism.


name: sodium-transporting ATPase activity, rotational mechanism

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism.


description: The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity

description: Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other.


nuclear retinoid X receptor binding

description: Binding to a nuclear retinoid X receptor.


name: nuclear thyroid hormone receptor binding

description: Binding to a nuclear thyroid hormone receptor.


name: cytosol to endoplasmic reticulum transport

description: The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell.


peptide antigen transport

description: The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.


name: NAD-dependent histone H3K9 deacetylase activity

description: Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.


name: NAD-dependent histone H4K16 deacetylase activity

description: Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.


name: histone H4K16 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4.


histone H3K9 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein.


name: histone H3K36 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein.


name: histone H3K27 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein.


TAP binding

description: Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2.


TAP1 binding

description: Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein.


TAP2 binding

description: Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein.


tapasin binding

description: Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules.


description: Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids.


protein heterodimerization activity

description: Binding to a nonidentical protein to form a heterodimer.


protein dimerization activity

description: The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.


name: regulation of hemoglobin biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


name: positive regulation of hemoglobin biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


name: negative regulation of hemoglobin biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


description: Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine).


description: Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid.


name: galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity

description: Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids.


description: Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine.


name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

description: Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y.


name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen.


name: oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound.


name: oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

description: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound.


name: oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin.


(S)-usnate reductase activity

description: Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD+ = (S)-usnate + 2 H+ + NADH.


description: Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP+ = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H+ + NADPH.


description: Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate.


L-arabinitol 2-dehydrogenase activity

description: Catalysis of the reaction: L-arabinitol + NAD+ = L-ribulose + H+ + NADH.


description: Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH.


description: Catalysis of the reaction: H2O + 2 NAD+ + UDP-N-acetyl-alpha-D-glucosamine = 3 H+ + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate.


name: 16-alpha-hydroxysteroid dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid.


description: Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone.


name: pregnan-21-ol dehydrogenase (NAD+) activity

description: Catalysis of the reaction: NAD+ + pregnan-21-ol = H+ + NADH + pregnan-21-al.


name: pregnan-21-ol dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + pregnan-21-ol = H+ + NADPH + pregnan-21-al.


description: Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione.


description: Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H+ + NADH.


name: 2-dehydropantolactone reductase (A-specific) activity

description: Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+.


name: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity

description: Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one.


cholate 12-alpha dehydrogenase activity

description: Catalysis of the reaction: cholate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H+ + NADPH.


name: glycerol-3-phosphate 1-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + H+ + NADPH.


description: Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA.


description: Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one.


prostaglandin F synthase activity

description: Catalysis of the reaction: NADP+ + prostaglandin F2alpha = H+ + NADPH + prostaglandin D2.


name: indole-3-acetaldehyde reductase (NADH) activity

description: Catalysis of the reaction: indole-3-ethanol + NAD+ = (indol-3-yl)acetaldehyde + H+ + NADH.


name: indole-3-acetaldehyde reductase (NADPH) activity

description: Catalysis of the reaction: indole-3-ethanol + NADP+ = (indol-3-yl)acetaldehyde + H+ + NADPH.


name: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate.


name: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H+ + NADPH.


name: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid.


androsterone dehydrogenase activity

description: Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione.


description: Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH.


name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity

description: Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein].


name: androsterone dehydrogenase (A-specific) activity

description: Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+.


description: Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP+ = benzyl 2-methyl-3-oxobutanoate + H+ + NADPH.


description: Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin.


name: (R)-4-hydroxyphenyllactate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + (R)-3-(4-hydroxyphenyl)lactate = NADPH + H+ + 3-(4-hydroxyphenyl)pyruvate.


description: Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD+ = 4-oxocyclohexanecarboxylate + H+ + NADH.


name: diethyl 2-methyl-3-oxosuccinate reductase activity

description: Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ = diethyl 2-methyl-3-oxosuccinate + H+ + NADPH.


description: Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP+ = 3-oxoglycyrrhetinate + H+ + NADPH.


name: 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H+ + NADPH.


description: Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate.


name: testosterone dehydrogenase (NAD+) activity

description: Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.


codeinone reductase (NADPH) activity

description: Catalysis of the reaction: codeine + NADP+ = codeinone + H+ + NADPH.


salutaridine reductase (NADPH) activity

description: Catalysis of the reaction: (7S)-salutaridinol + NADP+ = H+ + NADPH + salutaridine.


D-arabinitol 2-dehydrogenase activity

description: Catalysis of the reaction: D-arabinitol + NAD+ = D-ribulose + H+ + NADH.


description: Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol.


pteridine reductase activity

description: Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 H+ + 2 NADPH.


(S)-carnitine 3-dehydrogenase activity

description: Catalysis of the reaction: (S)-carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH.


name: androsterone dehydrogenase (B-specific) activity

description: Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+.


description: Catalysis of the reaction: lithocholate + NAD+ = 3-oxo-5beta-cholanate + H+ + NADH.


description: Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+.


name: testosterone 17-beta-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione.


homoisocitrate dehydrogenase activity

description: Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.


name: oxaloglycolate reductase (decarboxylating) activity

description: Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate.


description: Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP+ = 3-hydroxybenzaldehyde + H+ + NADPH.


name: (R)-2-hydroxy-fatty acid dehydrogenase activity

description: Catalysis of the reaction: (R)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH.


name: (S)-2-hydroxy-fatty acid dehydrogenase activity

description: Catalysis of the reaction: (S)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH.


name: D-lactate dehydrogenase (cytochrome c-553) activity

description: Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate.


(S)-stylopine synthase activity

description: Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O.


(S)-cheilanthifoline synthase activity

description: Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 = (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H2O.


berbamunine synthase activity

description: Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O.


salutaridine synthase activity

description: Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O.


(S)-canadine synthase activity

description: Catalysis of the reaction: (S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H2O.


name: vitamin-K-epoxide reductase (warfarin-sensitive) activity

description: Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues.


name: vitamin-K-epoxide reductase (warfarin-insensitive) activity

description: Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.


name: polyvinyl alcohol dehydrogenase (cytochrome) activity

description: Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+.


name: (R)-pantolactone dehydrogenase (flavin) activity

description: Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2).


description: Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone.


description: Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP+ = acenaphthene-1,2-dione + 2 H+ + 2 NADPH.


name: sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity

description: Catalysis of the reaction: O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O.


name: sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity

description: Catalysis of the reaction: O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O.


name: phospholipid-hydroperoxide glutathione peroxidase activity

description: Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.


description: Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone.


description: Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H+.


description: Catalysis of the reaction: 7,8-dihydroxykynurenate + O2 = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H+.


description: Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate.


description: Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H+.


description: Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H+.


description: Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H+.


description: Catalysis of the reaction: benzene-1,2,4-triol + O2 = maleylacetate + 2 H+.


description: Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate.


name: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity

description: Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin.


description: Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate.


deoxyuridine 1'-dioxygenase activity

description: Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil.


deoxyuridine 2'-dioxygenase activity

description: Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine.


description: Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate.


description: Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H+ + NADPH + O2 = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol.


description: Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate.


description: Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine.


description: Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H+ + NADPH + O2 = 4-hydroxymandelonitrile + H2O + NADP+.


ketosteroid monooxygenase activity

description: Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate.


protopine 6-monooxygenase activity

description: Catalysis of the reaction: H+ + NADPH + O2 + protopine = 6-hydroxyprotopine + H2O + NADP+.


description: Catalysis of the reaction: dihydrosanguinarine + H+ + NADPH + O2 = 10-hydroxydihydrosanguinarine + H2O + NADP+.


description: Catalysis of the reaction: dihydrochelirubine + H+ + NADPH + O2 = 12-hydroxydihydrochelirubine + H2O + NADP+.


benzoyl-CoA 3-monooxygenase activity

description: Catalysis of the reaction: benzoyl-CoA + H+ + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP+.


name: L-lysine 6-monooxygenase (NADPH) activity

description: Catalysis of the reaction: L-lysine + NADPH + O2 = N(6)-hydroxy-L-lysine + H2O + NADP+.


description: Catalysis of the reaction: H+ + NADH + O2 + quinolin-4-ol = H2O + NAD+ + quinoline-3,4-diol.


description: Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate.


description: Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP+.


description: Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone.


name: phylloquinone monooxygenase (2,3-epoxidizing) activity

description: Catalysis of the reaction: AH(2) + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O.


name: Latia-luciferin monooxygenase (demethylating) activity

description: Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin.


description: Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose.


name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity

description: Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate.


name: branched-chain alpha-keto acid dehydrogenase activity

description: Catalysis of the reaction: [a branched-chain alpha-keto acid] + CoA + NAD+ = [a branched-chain acyl-CoA] + CO2 + NADH. This enzyme system catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs.


description: Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate.


name: hexadecanal dehydrogenase (acylating) activity

description: Catalysis of the reaction: CoA + NAD+ + palmitaldehyde = H+ + NADH + palmitoyl-CoA.


description: Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate.


description: Catalysis of the reaction: (4-hydroxyphenyl)acetaldehyde + H2O + NAD+ = 4-hydroxyphenylacetate + 2 H+ + NADH.


description: Catalysis of the reaction: 4-guanidinobutanal + H2O + NAD+ = 4-guanidinobutanoate + 2 H+ + NADH.


description: Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH.


description: Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH.


name: phenylglyoxylate dehydrogenase (acylating) activity

description: Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = benzoyl-CoA + CO2 + NADH.


name: formate dehydrogenase (cytochrome-c-553) activity

description: Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2.


pyruvate oxidase activity

description: Catalysis of the reaction: H+ + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2.


name: aldehyde dehydrogenase (quinone) activity

description: Catalysis of the reaction: a quinone + an aldehyde + H2O = a carboxylate + a quinol + H+.


description: Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD+ = 7,8-dihydroxykynurenate + H+ + NADH.


description: Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol.


description: Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol.


description: Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ + NADPH.


description: Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH.


isoquinoline 1-oxidoreductase activity

description: Catalysis of the reaction: A + H2O + isoquinoline = AH(2) + isoquinolin-1(2H)-one.


quinaldate 4-oxidoreductase activity

description: Catalysis of the reaction: A + H2O + quinaldate = AH(2) + kynurenate.


description: Catalysis of the reaction: A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2).


description: Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H2O + NAD+ = (S)-5-amino-3-oxo-hexanoate + H+ + NADH + NH4.


description: Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate.


description: Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H2O + NADP+ = L-ornithine + H+ + NADPH + pyruvate.


description: Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate.


name: 1,2-dehydroreticulinium reductase (NADPH) activity

description: Catalysis of the reaction: (R)-reticuline + NADP+ = 1,2-dehydroreticuline + H+ + NADPH.


opine dehydrogenase activity

description: Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD+ = L-2-aminopentanoate + H+ + NADH + pyruvate.


name: saccharopine dehydrogenase (NADP+, L-lysine-forming) activity

description: Catalysis of the reaction: L-saccharopine + H2O + NADP+ = 2-oxoglutarate + L-lysine + H+ + NADPH.


name: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity

description: Catalysis of the reaction: L-saccharopine + H2O + NAD+ = L-glutamate + allysine + H+ + NADH.


description: Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine.


dimethylamine dehydrogenase activity

description: Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine.


name: protein-disulfide reductase (NAD(P)H) activity

description: Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+.


description: Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP+ = bis-gamma-glutamylcystine + H+ + NADPH.


description: Catalysis of the reaction: 4-(dimethylamino)azobenzene + H2O + NADP+ = 4-(dimethylamino)phenylazoxybenzene + H+ + NADPH.


description: Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+.


description: Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine.


description: Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione.


description: Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine.


name: enzyme-thiol transhydrogenase (glutathione-disulfide) activity

description: Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase.


chlorate reductase activity

description: Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H2O + H+.


description: Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA.


description: Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine.


description: Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine.


description: Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H+.


description: Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH4.


description: Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H+.


description: Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine.


name: tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent

description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+.


description: Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide.


description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate.


description: Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA.


description: Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem.


description: Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde.


description: Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA.


description: Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose.


plasmalogen synthase activity

description: Catalysis of the reaction: 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA.


description: Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA.


description: Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate.


description: Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA.


description: Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA.


description: Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA.


description: Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA.


description: Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA.


description: Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA.


description: Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA.


description: Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA.


description: Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA.


description: Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA.


description: Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA.


description: Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine.


description: Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H+.


description: Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein].


description: Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose.


name: glycerophospholipid arachidonoyl-transferase (CoA-independent) activity

description: Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine.


name: glycerophospholipid acyltransferase (CoA-dependent) activity

description: Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine.


name: platelet-activating factor acetyltransferase activity

description: Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid.


description: Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA.


description: Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A.


alcohol O-cinnamoyltransferase activity

description: Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate.


name: anthocyanin 5-aromatic acyltransferase activity

description: Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA.


description: Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA.


description: Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA.


name: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity

description: Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA.


description: Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate.


description: Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl.


description: Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA.


description: Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.


description: Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA.


description: Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA.


description: Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose.


description: Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol.


description: Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA.


description: Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol.


description: Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+.


description: Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol.


description: Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = L-2-acetamido-6-oxopimelate + CoA.


description: Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose.


description: Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose.


description: Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA.


description: Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate.


description: Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA.


description: Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA(Ala) = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA(Ala).


description: Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1).


description: Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H+ + UDP.


description: Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP.


name: alpha-1,4-glucan-protein synthase (ADP-forming) activity

description: Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP.


description: Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H+ + UDP.


description: Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP.


description: Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP.


description: Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP.


description: Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP.


description: Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose.


description: Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP.


description: Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H+ + UDP.


description: Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP.


description: Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H+ + UDP.