cAMP receptor activity

description: Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: G protein-coupled cytokinin receptor activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


proteinase-activated receptor activity

description: A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.


osteoblast differentiation

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.


fibrillar center

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.


dense fibrillar component

description: A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.


granular component

description: A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.


peptide receptor activity

description: Combining with an extracellular or intracellular peptide to initiate a change in cell activity.


eye development

description: The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.


urogenital system development

description: The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.


metanephros development

description: The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.


ureteric bud development

description: The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.


name: branching involved in ureteric bud morphogenesis

description: The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.


temperature homeostasis

description: A homeostatic process in which an organism modulates its internal body temperature.


fever generation

description: The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.


conditioned taste aversion

description: A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.


behavioral fear response

description: An acute behavioral change resulting from a perceived external threat.


G protein-coupled receptor binding

description: Binding to a G protein-coupled receptor.


description: Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.


response to hypoxia

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.


ameboidal-type cell migration

description: Cell migration that is accomplished by extension and retraction of a pseudopodium.


acrosomal vesicle

description: A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.


ATPase activator activity

description: Binds to and increases the activity of an ATP hydrolysis activity.


male germ cell nucleus

description: The nucleus of a male germ cell, a reproductive cell in males.


female germ cell nucleus

description: The nucleus of the female germ cell, a reproductive cell in females.


acrosome assembly

description: The formation of the acrosome from the spermatid Golgi.


long-chain fatty acid metabolic process

description: The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


name: formation of translation initiation ternary complex

description: Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).


intracellular glucose homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of glucose within a cell.


tRNA 3'-terminal CCA addition

description: Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition.


sialate O-acetylesterase activity

description: Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate.


tRNA 5'-leader removal

description: Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.


pseudophosphatase activity

description: Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues.


histamine metabolic process

description: The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.


histamine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.


histamine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.


gastric acid secretion

description: The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


name: histamine-induced gastric acid secretion

description: The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP.


gastrin-induced gastric acid secretion

description: The regulated release of gastric acid induced by the interaction of gastrin with its receptor.


name: acetylcholine-induced gastric acid secretion

description: The regulated release of gastric acid by parietal cells in response to acetylcholine.


name: embryonic development via the syncytial blastoderm

description: The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.


in utero embryonic development

description: The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.


gastrulation with mouth forming second

description: A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.


gastrulation with mouth forming first

description: A gastrulation process in which the initial invagination becomes the mouth and the anus forms second.


formation of primary germ layer

description: The formation of the ectoderm, mesoderm and endoderm during gastrulation.


ectoderm formation

description: The formation of ectoderm during gastrulation.


endoderm formation

description: The formation of the endoderm during gastrulation.


mesoderm formation

description: The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.


cell fate specification

description: The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate.


cell fate determination

description: The cellular developmental process involved in cell fate commitment that occurs after cell fate specification, in which a cell is irreversibly committed to a cellular developmental fate which is heritable on cell division.


mesodermal cell fate commitment

description: The cell differentiation process that results in commitment of a cell to become part of the mesoderm.


endodermal cell fate commitment

description: The cell differentiation process that results in commitment of a cell to become part of the endoderm.


ectodermal cell fate commitment

description: The cell differentiation process that results in commitment of a cell to become part of the ectoderm.


ectodermal cell fate determination

description: The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.


endodermal cell fate specification

description: The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


ectodermal cell fate specification

description: The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


L-amino-acid oxidase activity

description: Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.


name: conversion of seryl-tRNAsec to selenocys-tRNAsec

description: The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine.


name: conversion of lysyl-tRNA to pyrrolysyl-tRNA

description: The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate).


stress fiber

description: A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.


ruffle

description: Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.


lipid kinase activity

description: Catalysis of the phosphorylation of a simple or complex lipid.


ceramide kinase activity

description: Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate.


description: Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.


name: formation of translation preinitiation complex

description: The joining of the small ribosomal subunit, ternary complex, and mRNA.


name: formation of cytoplasmic translation initiation complex

description: Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.


description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.


mRNA m(6)A methyltransferase activity

description: Catalysis of the reaction: an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H+ + S-adenosyl-L-homocysteine. This activity is the methylation of adenines in mRNA with the consensus sequence RRACH, where R is a purine, and H is C, A, or U.


prenylcysteine oxidase activity

description: Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.


establishment of planar polarity

description: Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.


name: establishment of imaginal disc-derived wing hair orientation

description: Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.


morphogenesis of a polarized epithelium

description: The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.


sex chromatin

description: Chromatin that is part of a sex chromosome.


Barr body

description: A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.


XY body

description: A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.


oenocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.


lens placode formation

description: The initial developmental process that will lead to the formation of an eye.


insect visual primordium formation

description: Establishment of the optic lobe placode. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system.


compound eye morphogenesis

description: The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.


Bolwig's organ morphogenesis

description: The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain.


insect visual primordium development

description: The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster.


photoreceptor outer segment

description: The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.


name: compound eye photoreceptor cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.


name: compound eye photoreceptor fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.


eye photoreceptor cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.


neural crest cell migration

description: The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.


somitogenesis

description: The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.


somite specification

description: The process in which individual somites establish identity during embryogenesis.


retinal dehydrogenase activity

description: Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.


organ induction

description: The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.


description: Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H+ = 2-aminomuconate 6-semialdehyde + CO2.


name: beta-alanine transmembrane transporter activity

description: Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid.


beta-alanine transport

description: The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


morphogenesis of a branching structure

description: The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.


neuron migration

description: The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.


membrane raft assembly

description: The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.


membrane raft polarization

description: The clustering and aggregation of a membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity.


establishment of lymphocyte polarity

description: The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.


establishment of T cell polarity

description: The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.


establishment of B cell polarity

description: The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell.


name: establishment of natural killer cell polarity

description: The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands.


immunological synapse formation

description: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.


immunological synapse

description: An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.


myeloid dendritic cell activation

description: The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


microglial cell activation

description: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


cell activation

description: A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell.


leukocyte homeostasis

description: The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.


T cell homeostatic proliferation

description: The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.


plasma membrane repair

description: The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.


natural killer cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.


neutrophil homeostasis

description: The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.


neutrophil apoptotic process

description: Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.


B cell homeostasis

description: The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


B cell apoptotic process

description: Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.


phosphotyrosine residue binding

description: Binding to a phosphorylated tyrosine residue within a protein.


prostaglandin J receptor activity

description: Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.


phosphatidylserine binding

description: Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.


natural killer cell proliferation

description: The expansion of a natural killer cell population by cell division.


description: Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.


polymeric immunoglobulin binding

description: Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes.


IgM binding

description: Binding to an immunoglobulin of the IgM isotype.


name: polymeric immunoglobulin receptor activity

description: Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


IgM receptor activity

description: Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


type IIa hypersensitivity

description: An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell.


type IIb hypersensitivity

description: An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors.


regulation of type IIa hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response.


name: negative regulation of type IIa hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response.


name: positive regulation of type IIa hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.


regulation of type IIb hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response.


name: negative regulation of type IIb hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response.


name: positive regulation of type IIb hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response.


type III hypersensitivity

description: An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue.


regulation of type III hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response.


name: negative regulation of type III hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response.


name: positive regulation of type III hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response.


type IV hypersensitivity

description: An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.


regulation of type IV hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response.


name: negative regulation of type IV hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.


name: positive regulation of type IV hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.


regulation of type I hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response.


name: negative regulation of type I hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response.


name: positive regulation of type I hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.


name: regulation of antibody-dependent cellular cytotoxicity

description: Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity.


name: negative regulation of antibody-dependent cellular cytotoxicity

description: Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity.


name: positive regulation of antibody-dependent cellular cytotoxicity

description: Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity.


cytokine production

description: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


regulation of cytokine production

description: Any process that modulates the frequency, rate, or extent of production of a cytokine.


name: negative regulation of cytokine production

description: Any process that stops, prevents, or reduces the rate of production of a cytokine.


name: positive regulation of cytokine production

description: Any process that activates or increases the frequency, rate or extent of production of a cytokine.


serotonin secretion

description: The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.


histamine secretion

description: The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.


kidney development

description: The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.


mesonephros development

description: The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.


blastocyst development

description: The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.


blastocyst formation

description: The initial formation of a blastocyst from a solid ball of cells known as a morula.


inner cell mass cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.


inner cell mass cell fate commitment

description: The cell fate commitment of precursor cells that will become inner cell mass cells.


inner cell mass cellular morphogenesis

description: The morphogenesis of cells in the inner cell mass.


trophectodermal cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.


trophectodermal cell fate commitment

description: The cell fate commitment of precursor cells that will become trophectoderm cells.


trophectodermal cellular morphogenesis

description: The morphogenesis of trophectoderm cells.


blastocyst growth

description: An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.


inner cell mass cell proliferation

description: The proliferation of cells in the inner cell mass.


trophectodermal cell proliferation

description: The proliferation of cells in the trophectoderm.


blastocyst hatching

description: The hatching of the cellular blastocyst from the zona pellucida.


name: release of cytochrome c from mitochondria

description: The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.


epithelial to mesenchymal transition

description: A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


embryonic epithelial tube formation

description: The morphogenesis of an embryonic epithelium into a tube-shaped structure.


neural plate morphogenesis

description: The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.


neural plate development

description: The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.


neural tube formation

description: The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.


neural fold formation

description: The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.


neural tube closure

description: The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.


phagolysosome assembly

description: The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.


opsonin binding

description: Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.


opsonin receptor activity

description: Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


complement binding

description: Binding to a component or product of the complement cascade.


name: complement component C1q complex binding

description: Binding to a C1q complex, a component of the classical complement cascade.


complement component C3a binding

description: Binding to a C3a product of the complement cascade.


complement component C3b binding

description: Binding to a C3b product of the complement cascade.


complement component iC3b binding

description: Binding to a iC3b product of the complement cascade.


complement component C3dg binding

description: Binding to a C3dg product of the complement cascade.


complement component C3d binding

description: Binding to a C3d product of the complement cascade.


complement component C4b binding

description: Binding to a C4b product of the classical complement cascade.


complement component C5a binding

description: Binding to a C5a product of the complement cascade.


name: complement component C1q receptor activity

description: Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: complement component iC3b receptor activity

description: Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: complement component C3dg receptor activity

description: Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: complement component C3d receptor activity

description: Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: complement component C4b receptor activity

description: Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


collectin binding

description: Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus.


collectin receptor activity

description: Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


pentraxin binding

description: Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array.


NK T cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a NK T cell.


NK T cell proliferation

description: The expansion of a NK T cell population by cell division.


complement activation, lectin pathway

description: Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.


name: regulation of complement activation, lectin pathway

description: Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation.


name: negative regulation of complement activation, lectin pathway

description: Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.


name: positive regulation of complement activation, lectin pathway

description: Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway.


(1->3)-beta-D-glucan binding

description: Binding to a (1->3)-beta-D-glucan.


polysaccharide immune receptor activity

description: Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


name: (1->3)-beta-D-glucan immune receptor activity

description: Combining with (1->3)-beta-D-glucans to initiate an innate immune response.


name: lipopolysaccharide immune receptor activity

description: Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.


lipoarabinomannan binding

description: Binding to lipoarabinomannan.


name: lipoarabinomannan immune receptor activity

description: Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response.


response to yeast

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.


detection of yeast

description: The series of events in which a stimulus from a yeast is received and converted into a molecular signal.


Mullerian duct regression

description: The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos.


receptor recycling

description: The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.


nucleoside binding

description: Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.


purine nucleoside binding

description: Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.


pyrimidine nucleoside binding

description: Binding to a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose.


endothelial cell development

description: The progression of an endothelial cell over time, from its formation to the mature structure.


endothelial cell morphogenesis

description: The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.


selenium compound metabolic process

description: The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.


liver development

description: The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.


placenta development

description: The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.


phagocytic cup

description: An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.


embryonic placenta development

description: The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.


maternal placenta development

description: Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.


tissue homeostasis

description: A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.


retina homeostasis

description: A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.


autolysis

description: A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation.


name: symbiont-mediated cytolysis of host cell

description: A process mediated by a symbiont that results in the death of a host cell by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.


activation of membrane attack complex

description: The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.


cell killing

description: Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.


symbiont-mediated killing of host cell

description: A process mediated by a symbiont that results in the death of a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


leukocyte mediated cytotoxicity

description: The directed killing of a target cell by a leukocyte.


name: regulation of leukocyte mediated cytotoxicity

description: Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.


name: negative regulation of leukocyte mediated cytotoxicity

description: Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.


name: positive regulation of leukocyte mediated cytotoxicity

description: Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.


T cell mediated cytotoxicity

description: The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.


name: regulation of T cell mediated cytotoxicity

description: Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.


name: negative regulation of T cell mediated cytotoxicity

description: Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.


name: positive regulation of T cell mediated cytotoxicity

description: Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.


photoreceptor inner segment

description: The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.


farnesylated protein binding

description: Binding to a farnesylated protein.


regulation of receptor recycling

description: Any process that modulates the frequency, rate, or extent of receptor recycling.


name: negative regulation of receptor recycling

description: Any process that stops, prevents, or reduces the rate of receptor recycling.


name: positive regulation of receptor recycling

description: Any process that activates or increases the frequency, rate or extent of receptor recycling.


B-1 B cell homeostasis

description: The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.


B-1 B cell differentiation

description: The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.


name: regulation of B-1 B cell differentiation

description: Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.


name: negative regulation of B-1 B cell differentiation

description: Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation.


name: positive regulation of B-1 B cell differentiation

description: Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation.


exocyst assembly

description: The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex.


regulation of exocyst assembly

description: Any process that modulates the frequency, rate or extent of exocyst assembly.


negative regulation of exocyst assembly

description: Any process that stops, prevents, or reduces the rate or extent of exocyst assembly.


positive regulation of exocyst assembly

description: Any process that increases the rate or extent of exocyst assembly.


uropod

description: A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.


regulation of protein phosphorylation

description: Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.


name: negative regulation of protein phosphorylation

description: Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.


name: positive regulation of protein phosphorylation

description: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.


endothelial cell proliferation

description: The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.


name: regulation of endothelial cell proliferation

description: Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.


name: negative regulation of endothelial cell proliferation

description: Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.


name: positive regulation of endothelial cell proliferation

description: Any process that activates or increases the rate or extent of endothelial cell proliferation.


female pronucleus

description: The pronucleus originating from the ovum that is being fertilized.


male pronucleus

description: The pronucleus originating from the spermatozoa that was involved in fertilization.


postsynaptic membrane organization

description: A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).


hair follicle development

description: The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.


vasculature development

description: The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.


lymph vessel development

description: The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.


lymphangiogenesis

description: Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.


heart looping

description: The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceding septation.


sebaceous gland cell differentiation

description: The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell.


intestinal D-glucose absorption

description: Uptake of D-glucose into the blood by absorption from the small intestine.


regulation of cell-matrix adhesion

description: Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.


name: negative regulation of cell-matrix adhesion

description: Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.


name: positive regulation of cell-matrix adhesion

description: Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.


blood vessel maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.


name: positive regulation of neurotransmitter secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.


intramembranous ossification

description: Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.


endochondral ossification

description: Replacement ossification wherein bone tissue replaces cartilage.


name: regulation of cytokine-mediated signaling pathway

description: Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.


name: negative regulation of cytokine-mediated signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.


name: positive regulation of cytokine-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.


description: Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage.


synaptic transmission, dopaminergic

description: The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


startle response

description: An action or movement due to the application of a sudden unexpected stimulus.


G-protein alpha-subunit binding

description: Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.


thigmotaxis

description: The directed movement of an animal in response to touch.


suckling behavior

description: Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.


fibronectin binding

description: Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.


name: regulation of activation of membrane attack complex

description: Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.


name: positive regulation of activation of membrane attack complex

description: Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.


name: negative regulation of activation of membrane attack complex

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.


retinoic acid binding

description: Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid.


name: G protein-coupled adenosine receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.


blood vessel remodeling

description: The reorganization or renovation of existing blood vessels.


response to amphetamine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.


name: nervous system process involved in regulation of systemic arterial blood pressure

description: The regulation of blood pressure mediated by detection of stimuli and a neurological response.


name: renal system process involved in regulation of blood volume

description: A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.


name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

description: The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control.


name: regulation of systemic arterial blood pressure by chemoreceptor signaling

description: The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.


name: regulation of systemic arterial blood pressure by ischemic conditions

description: The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.


name: baroreceptor detection of arterial stretch

description: The series of events by which the change in diameter of an artery is detected and converted to a molecular signal.


name: baroreceptor response to decreased systemic arterial blood pressure

description: The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels.


name: baroreceptor response to increased systemic arterial blood pressure

description: The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels.


name: artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure

description: An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure.


name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

description: Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure.


name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure

description: Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure.


name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure

description: A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure.


name: positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure

description: Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure.


name: regulation of systemic arterial blood pressure by hormone

description: The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.


name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin

description: The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.


name: regulation of systemic arterial blood pressure by vasopressin

description: The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport.


name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine

description: The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system.


name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

description: A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure.


name: norepinephrine-epinephrine catabolic process in blood stream

description: The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream.


name: positive regulation of heart rate by epinephrine-norepinephrine

description: The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.


name: positive regulation of the force of heart contraction by epinephrine-norepinephrine

description: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.


name: angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure

description: The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream.


name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

description: The physiological response of the kidneys to a decrease in blood flow.


detection of renal blood flow

description: The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal.


renin secretion into blood stream

description: The regulated release of renin into the blood stream by juxtoglomerular cells.


name: regulation of angiotensin levels in blood

description: The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation.


angiotensin maturation

description: The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.


name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure

description: The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure.


name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control

description: The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream.


name: detection of hypoxic conditions in blood by chemoreceptor signaling

description: The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.


name: excitation of vasomotor center by chemoreceptor signaling

description: The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure.


morphogenesis of an epithelium

description: The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.


name: excitation of vasomotor center by baroreceptor signaling

description: The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure.


morphogenesis of an epithelial sheet

description: The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.


name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure

description: A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.


name: detection of carbon dioxide by vasomotor center

description: The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system.


name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure

description: The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system.


name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback

description: A process that controls blood pressure by sensing the amount of stretch occurring in the atria.


name: regulation of blood volume by renin-angiotensin

description: The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.


name: regulation of blood volume by renal aldosterone

description: The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume.


name: renin-angiotensin regulation of aldosterone production

description: The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.


name: regulation of renal output by angiotensin

description: The process in which angiotensin directly modulates the rate of urine output by the kidney.


protease binding

description: Binding to a protease or a peptidase.


response to dietary excess

description: The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.


detection of dietary excess

description: The neurological process in which the brain senses excessive caloric intake.


name: reduction of food intake in response to dietary excess

description: An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients.


diet induced thermogenesis

description: The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signaling in the sympathetic nervous system.


name: norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

description: A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.


name: regulation of the force of heart contraction

description: Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.


regulation of heart rate

description: Any process that modulates the frequency or rate of heart contraction.


regulation of sodium ion transport

description: Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: desensitization of G protein-coupled receptor signaling pathway

description: The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.


name: inhibitory G protein-coupled receptor phosphorylation

description: The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site.


name: G protein-coupled receptor internalization

description: The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.


name: angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure

description: The process that increases the diameter of a blood vessel via the renin-angiotensin system.


name: maintenance of blood vessel diameter homeostasis by renin-angiotensin

description: The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system.


brain renin-angiotensin system

description: The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.


name: regulation of L-glutamate import across plasma membrane

description: Any process that modulates the frequency, rate or extent of L-glutamate import into a cell.


name: negative regulation of L-glutamate import across plasma membrane

description: Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell.


name: positive regulation of L-glutamate import across plasma membrane

description: Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell.


p53 binding

description: Binding to one of the p53 family of proteins.


sprouting angiogenesis

description: The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.


intussusceptive angiogenesis

description: The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.


name: cell migration involved in sprouting angiogenesis

description: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.


name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis

description: The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.


name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis

description: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis.


name: regulation of cell adhesion involved in intussusceptive angiogenesis

description: The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis.


opsin binding

description: Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception.


phenazine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.


pyoverdine metabolic process

description: The chemical reactions and pathways involving the siderochrome pyoverdine.


pyoverdine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.


pyoverdine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine.


osteoblast fate commitment

description: The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.


name: positive regulation of neuroblast proliferation

description: Any process that activates or increases the rate of neuroblast proliferation.


name: positive regulation of mesenchymal cell proliferation

description: The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.


nucleobase binding

description: Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases.


adenine binding

description: Binding to adenine, a purine base.


cytosine binding

description: Binding to cytosine.


guanine binding

description: Binding to guanine.


uracil binding

description: Binding to uracil.


thymine binding

description: Binding to thymine.


purine nucleobase binding

description: Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton.


pyrimidine nucleobase binding

description: Binding to a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton.


chondrocyte differentiation

description: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.


chondrocyte development

description: The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.


epithelial cell development

description: The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.


name: columnar/cuboidal epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.


name: columnar/cuboidal epithelial cell development

description: The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.


name: glandular epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


glandular epithelial cell development

description: The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


name: columnar/cuboidal epithelial cell maturation

description: The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.


epithelial cell maturation

description: The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.


glandular epithelial cell maturation

description: The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


name: optic cup morphogenesis involved in camera-type eye development

description: The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.


extraocular skeletal muscle development

description: The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.


somitomeric trunk muscle development

description: The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.


osteoblast development

description: The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.


acrosome matrix dispersal

description: The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane.


name: membrane fusion involved in acrosome reaction

description: The fusion of the plasma membrane of the sperm with the outer acrosomal membrane.


inner acrosomal membrane

description: The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.


acrosomal membrane

description: The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.


outer acrosomal membrane

description: The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.


regulation of oxidative phosphorylation

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.


description: Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate.


protein depalmitoylation

description: The removal of palymitoyl groups from a lipoprotein.


name: inhibition of neuroepithelial cell differentiation

description: Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.


diaphragm contraction

description: A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange.


name: regulation of respiratory gaseous exchange by nervous system process

description: A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.


lens development in camera-type eye

description: The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.


lens morphogenesis in camera-type eye

description: The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.


regulation of receptor internalization

description: Any process that modulates the frequency, rate or extent of receptor internalization.


name: negative regulation of receptor internalization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.


name: positive regulation of receptor internalization

description: Any process that activates or increases the frequency, rate or extent of receptor internalization.


auditory receptor cell morphogenesis

description: Any process that alters the size or shape of an auditory receptor cell.


polyprenyltransferase activity

description: Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor).


name: caveolar macromolecular signaling complex

description: A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3).


polkadots

description: A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals.


tRNA wobble base modification

description: The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified.


tRNA wobble uridine modification

description: The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.


tRNA wobble guanine modification

description: The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified.


name: tRNA wobble adenosine to inosine editing

description: The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine.


tRNA wobble cytosine modification

description: The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.


podosome

description: An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.


name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

description: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.


name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

description: Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.


name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

description: Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.


name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

description: Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.


name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III

description: The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end.


name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

description: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript.


name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

description: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript.


name: cotranscriptional mitochondrial rRNA nucleotide insertion

description: The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis.


BRCA2-BRAF35 complex

description: A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis.


interleukin-33 receptor binding

description: Binding to an interleukin-33 receptor.


interleukin-33 binding

description: Binding to interleukin-33.


interleukin-33 receptor activity

description: Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


store-operated calcium entry

description: A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.


semaphorin receptor complex

description: A stable binary complex of a semaphorin and a plexin, together forming a functional semaphorin receptor.


amphibian larval development

description: The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form.


aggressive behavior

description: A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.


nematode larval development

description: The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.


inter-male aggressive behavior

description: Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.


fear-induced aggressive behavior

description: Aggressive behavior associated with attempts to flee from a threat.


irritable aggressive behavior

description: Aggressive behavior induced by frustration and directed against an available target.


territorial aggressive behavior

description: Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics.


maternal aggressive behavior

description: Aggressive behavior of a female to protect her offspring from a threat.


instrumental aggressive behavior

description: Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation.


tRNA wobble base cytosine methylation

description: The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position.


tRNA nucleoside ribose methylation

description: The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position.


name: wobble position guanine ribose methylation

description: The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.


wobble position ribose methylation

description: The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position.


name: wobble position cytosine ribose methylation

description: The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.


name: wobble position uridine ribose methylation

description: The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position.


polycystin complex

description: A stable heterodimeric complex composed of polycystin-1 and polycystin-2.


UTP binding

description: Binding to UTP, uridine 5'-triphosphate.


CTP binding

description: Binding to CTP, cytidine 5'-triphosphate.


tRNA wobble base lysidine biosynthesis

description: The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine.


retinoic acid biosynthetic process

description: The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.


stereocilia coupling link

description: A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle.


stereocilia tip link

description: A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia.


stereocilia ankle link

description: A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia.