ecdysis-triggering hormone activity

description: The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system.


protein histidine pros-kinase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine.


protein histidine tele-kinase activity

description: Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine.


head involution

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Movement of the anterior ectoderm to the interior of the embryo.


description: Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA.


allatostatin receptor activity

description: Combining with allatostatin to initiate a change in cell activity.


name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity

description: Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.


name: Mo-molybdopterin cofactor sulfurase activity

description: Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase.


poly(U) RNA binding

description: Binding to a sequence of uracil residues in an RNA molecule.


poly-glutamine tract binding

description: Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein.


name: JAK pathway signal transduction adaptor activity

description: The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way.


zinc ion binding

description: Binding to a zinc ion (Zn).


name: secondary active sulfate transmembrane transporter activity

description: Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.


sulfate transport

description: The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: calcium, potassium:sodium antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).


gamma-tubulin small complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex.


protein methyltransferase activity

description: Catalysis of the transfer of a methyl group (CH3-) to a protein.


name: regulation of G protein-coupled receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.


cohesin complex

description: A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).


sulfonylurea receptor activity

description: Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


inward rectifying potassium channel

description: A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.


cell population proliferation

description: The multiplication or reproduction of cells, resulting in the expansion of a cell population.


name: positive regulation of cell population proliferation

description: Any process that activates or increases the rate or extent of cell proliferation.


name: negative regulation of cell population proliferation

description: Any process that stops, prevents or reduces the rate or extent of cell proliferation.


insulin receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.


name: protein serine/threonine phosphatase complex

description: A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.


boss receptor activity

description: Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.


lipid binding

description: Binding to a lipid.


F-actin capping protein complex

description: A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.


acetylcholine metabolic process

description: The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.


acetylcholine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline.


torso signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: calcium- and calmodulin-responsive adenylate cyclase activity

description: Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.


spermidine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.


3'-5'-DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.


name: single-stranded DNA exodeoxyribonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule.


intracellular mRNA localization

description: Any process in which mRNA is transported to, or maintained in, a specific location within the cell.


isoprenoid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


isoprenoid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


DNA binding, bending

description: The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


name: female germline ring canal formation, actin assembly

description: Recruitment and organization of actin filaments in female germline ring canals.


caspase complex

description: A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes.


integrin complex

description: A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.


associative learning

description: Learning by associating a stimulus (the cause) with a particular outcome (the effect).


structural constituent of muscle

description: The action of a molecule that contributes to the structural integrity of a muscle fiber.


name: voltage-gated monoatomic anion channel activity

description: Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: double-stranded DNA exodeoxyribonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule.


name: single-stranded DNA 3'-5' DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.


name: double-stranded DNA 3'-5' DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule.


7S RNA binding

description: Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).


G2/MI transition of meiotic cell cycle

description: The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I.


name: structural constituent of vitelline membrane

description: The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster.


protein prenyltransferase activity

description: Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein.


name: protein transmembrane transporter activity

description: Enables the transfer of a protein from one side of a membrane to the other.


name: monoatomic cation transmembrane transporter activity

description: Enables the transfer of cation from one side of a membrane to the other.


methyl-CpG binding

description: Binding to a methylated cytosine/guanine dinucleotide.


ionotropic glutamate receptor complex

description: A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.


name: protein tyrosine/threonine phosphatase activity

description: Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


name: high voltage-gated calcium channel activity

description: Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.


name: low voltage-gated calcium channel activity

description: Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.


endosome to lysosome transport

description: The directed movement of substances from endosomes to lysosomes.


histone mRNA metabolic process

description: The chemical reactions and pathways involving an mRNA encoding a histone.


name: female germline ring canal stabilization

description: Maintenance of the structural integrity of the ring canals connecting the female germline cyst.


description: Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate.


determination of adult lifespan

description: The pathways that regulate the duration of the adult phase of the life-cycle of an animal.


adult feeding behavior

description: Feeding behavior in a fully developed and mature organism.


adult locomotory behavior

description: Locomotory behavior in a fully developed and mature organism.


larval locomotory behavior

description: Locomotory behavior in a larval (immature) organism.


larval walking behavior

description: The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg.


glial cell migration

description: The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.


name: negative regulation of antimicrobial humoral response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.


name: MAP kinase kinase kinase kinase activity

description: Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.


katanin complex

description: A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa).


name: RNA polymerase II CTD heptapeptide repeat kinase activity

description: Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.


germ cell migration

description: The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.


olfactory learning

description: Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.


asymmetric cell division

description: The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.


name: maternal determination of anterior/posterior axis, embryo

description: The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos.


regulation of bicoid mRNA localization

description: Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location.


regulation of cell shape

description: Any process that modulates the surface configuration of a cell.


regulation of cell size

description: Any process that modulates the size of a cell.


name: chitin-based embryonic cuticle biosynthetic process

description: Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster.


larval chitin-based cuticle development

description: Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster.


pupal chitin-based cuticle development

description: Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster.


adult chitin-based cuticle development

description: Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster.


axon ensheathment

description: Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.


sialyltransferase activity

description: Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.


O-acyltransferase activity

description: Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.


acetylglucosaminyltransferase activity

description: Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.


description: Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide.


galactosyltransferase activity

description: Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


thioredoxin peroxidase activity

description: Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O.


RNA splicing

description: The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.


name: mechanosensitive monoatomic ion channel activity

description: Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress.


IkappaB kinase activity

description: Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.


IkappaB kinase complex

description: A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.


name: cholesterol monooxygenase (side-chain-cleaving) activity

description: Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.


steroid 7-alpha-hydroxylase activity

description: Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O.


description: Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O.


coumarin 7-hydroxylase activity

description: Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+.


description: Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O.


arachidonic acid monooxygenase activity

description: Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water.


arachidonic acid epoxygenase activity

description: Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid.


steroid hydroxylase activity

description: Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.


oxysterol 7-alpha-hydroxylase activity

description: Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O.


sterol 12-alpha-hydroxylase activity

description: Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.


sterol 14-demethylase activity

description: Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase].


naphthalene hydroxylase activity

description: Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide.


retinoic acid 4-hydroxylase activity

description: Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid.


description: Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol.


name: arachidonic acid 14,15-epoxygenase activity

description: Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid.


name: arachidonic acid 11,12-epoxygenase activity

description: Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid.


gonad development

description: The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.


chaeta morphogenesis

description: The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.


3'-5' exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.


5'-3' exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.


CoA-transferase activity

description: Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).


description: Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate.


description: Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate.


name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

description: Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.


CDP-alcohol phosphotransferase activity

description: Catalysis of the transfer of a CDP-alcohol group from one compound to another.


fucosyltransferase activity

description: Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


name: protein-N-terminal asparagine amidohydrolase activity

description: Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein.


RNA lariat debranching enzyme activity

description: Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide.


name: RNA polymerase II CTD heptapeptide repeat phosphatase activity

description: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate.


name: long-chain fatty-acyl-glutamate deacylase activity

description: Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate.


beta-glucosidase activity

description: Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.


description: Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H+.


description: Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.


protein kinase C inhibitor activity

description: Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein.


name: calcium-dependent protein kinase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase.


ribonuclease inhibitor activity

description: Binds to and stops, prevents or reduces the activity of ribonuclease.


phosphatidylethanolamine binding

description: Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.


selenium binding

description: Binding to a selenium (Se) ion.


vitamin E binding

description: Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


JUN kinase binding

description: Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.


thyrotropin-releasing hormone activity

description: The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


description: Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+.


description: Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.


description: Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+.


phosphofructokinase activity

description: Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule.


description: Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+.


D-aspartate oxidase activity

description: Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide.


GDP-mannose 4,6-dehydratase activity

description: Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H2O.


L-ascorbate oxidase activity

description: Catalysis of the reaction: 4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O.


description: Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.


description: Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.


RNA ligase activity

description: Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the phosphate group at the end of another.


description: Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R.


description: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides.


description: Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA.


chondroitin 6-sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.


dTDP-glucose 4,6-dehydratase activity

description: Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.


formylmethionine deformylase activity

description: Catalysis of the reaction: N-formyl-L-methionine + H2O = L-methionine + formate.


name: hydroxypyruvate reductase (NADH) activity

description: Catalysis of the reaction: (R)-glycerate + NAD+ = 3-hydroxypyruvate + NADH + H+.


glycogenin glucosyltransferase activity

description: Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin.


name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

description: Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S.


name: histone arginine N-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.


isovaleryl-CoA dehydrogenase activity

description: Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].


ornithine cyclodeaminase activity

description: Catalysis of the reaction: L-ornithine = L-proline + NH4.


palmitoyl-(protein) hydrolase activity

description: Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.


description: Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.


description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.


purine nucleosidase activity

description: Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose.


pyridoxal kinase activity

description: Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.


name: tRNA-guanosine(34) queuine transglycosylase activity

description: Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA.


sarcosine dehydrogenase activity

description: Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.


sphinganine kinase activity

description: Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate.


sulfite oxidase activity

description: Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate.


transaminase activity

description: Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.


sulfuric ester hydrolase activity

description: Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.


description: Catalysis of the reaction: diphospho-1D-myo-inositol polyphosphate + H2O = 1D-myo-inositol polyphosphate + phosphate.


gamma-glutamyl carboxylase activity

description: Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide.


description: Catalysis of the reaction: a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H+ + UDP.


name: arsenite secondary active transmembrane transporter activity

description: Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.


name: tetracycline transmembrane transporter activity

description: Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).


translation activator activity

description: Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.


name: protoheme IX farnesyltransferase activity

description: Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate.


description: Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans.


description: Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP.


melatonin receptor activity

description: Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.


benzodiazepine receptor activity

description: Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.


name: monoamine transmembrane transporter activity

description: Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other.


name: sucrose:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in).


name: sodium:iodide symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).


bile acid:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in).


name: monoatomic anion transmembrane transporter activity

description: Enables the transfer of a negatively charged ion from one side of a membrane to the other.


name: sodium:bicarbonate symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).


description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).


name: sulfate:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in).


name: secondary active organic cation transmembrane transporter activity

description: Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.


name: organic anion transmembrane transporter activity

description: Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.


name: sucrose transmembrane transporter activity

description: Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane.


hexose uniporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in).


name: folic acid transmembrane transporter activity

description: Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.


name: folate:monoatomic anion antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF.


ammonium channel activity

description: Enables the energy-independent facilitated diffusion of ammonium through a transmembrane aqueous pore or channel.


name: L-ascorbate:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in).


name: acetyl-CoA transmembrane transporter activity

description: Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.


name: sodium-dependent multivitamin transmembrane transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate.


description: Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.


phosphatidylinositol transfer activity

description: Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


taste receptor activity

description: Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.


name: G protein-coupled peptide receptor activity

description: Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


riboflavin kinase activity

description: Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.


name: oxidized purine nucleobase lesion DNA N-glycosylase activity

description: Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.


respiratory chain complex IV assembly

description: The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms.


proteasome activator complex

description: A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex.


name: proteasome regulatory particle, base subcomplex

description: The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.


name: proteasome regulatory particle, lid subcomplex

description: The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.


visual learning

description: Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.


name: fibroblast growth factor receptor signaling pathway

description: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.


epidermis development

description: The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.


JUN kinase kinase activity

description: Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.


P-type cadmium transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out).


name: P-type proton-exporting transporter activity

description: Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.


P-type sodium transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism.


name: P-type potassium transmembrane transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in).


ABC-type guanine transporter activity

description: Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in).


name: ABC-type xenobiotic transporter activity

description: Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).


protein-exporting ATPase activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.


name: mitochondrial protein-transporting ATPase activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex.


microtubule severing ATPase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.


name: minus-end-directed microtubule motor activity

description: A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis.


name: plus-end-directed microtubule motor activity

description: A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis.


JUN kinase phosphatase activity

description: Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.


name: regulation of synaptic assembly at neuromuscular junction

description: Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions.


mystery cell differentiation

description: The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster.


male gonad development

description: The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.


female gonad development

description: The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.


name: imaginal disc-derived wing vein morphogenesis

description: The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized.


name: imaginal disc-derived wing margin morphogenesis

description: The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade.


name: regulation of smoothened signaling pathway

description: Any process that modulates the frequency, rate or extent of smoothened signaling.


name: regulation of Wnt signaling pathway, calcium modulating pathway

description: Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).


regulation of Toll signaling pathway

description: Any process that modulates the frequency, rate or extent of the Tl signaling pathway.


regulation of Notch signaling pathway

description: Any process that modulates the frequency, rate or extent of the Notch signaling pathway.


photoreceptor cell morphogenesis

description: The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.


name: anterior/posterior axis specification, embryo

description: The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.


name: calcium-dependent protein serine/threonine phosphatase regulator activity

description: Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase.


name: cAMP-dependent protein kinase regulator activity

description: Modulation of the activity of the enzyme cAMP-dependent protein kinase.


phosphorylase kinase regulator activity

description: Modulation of the activity of the enzyme phosphorylase kinase.


name: attachment of spindle microtubules to kinetochore

description: The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.


description: Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion.


lipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.


ether lipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.


name: peptidyl-lysine modification to peptidyl-hypusine

description: The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine.


diuretic hormone activity

description: The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion.


pyridoxine metabolic process

description: The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


pyridoxine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds.


queuosine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents.


guanosine metabolic process

description: The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution.


7-methylguanosine metabolic process

description: The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA.


epsilon DNA polymerase complex

description: A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.


CHRAC

description: An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair.


name: extrinsic apoptotic signaling pathway via death domain receptors

description: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.


name: granzyme-mediated apoptotic signaling pathway

description: The series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.


name: intrinsic apoptotic signaling pathway in response to osmotic stress

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered.


name: hormone-mediated apoptotic signaling pathway

description: The series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered.


name: intrinsic apoptotic signaling pathway in response to DNA damage

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.


name: intrinsic apoptotic signaling pathway in response to oxidative stress

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.


name: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

description: Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c.


apoptotic mitochondrial changes

description: The morphological and physiological alterations undergone by mitochondria during apoptosis.


name: ubiquitin-like modifier activating enzyme activity

description: Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.


carbohydrate transport

description: The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.


hexose transmembrane transport

description: The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule.


rRNA methyltransferase activity

description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule.


description: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.


amino acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.


lipopolysaccharide metabolic process

description: The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.


phospholipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.


pyrimidine-containing compound salvage

description: Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis.


name: cysteine-type endopeptidase activator activity involved in apoptotic process

description: Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.


name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

description: Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


penicillin binding

description: Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.


description: Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O.


description: Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanate + NH4.


description: Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2.


1-phosphofructokinase activity

description: Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate.


description: Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.


name: RNA 2',3'-cyclic 3'-phosphodiesterase activity

description: Catalysis the reaction: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H+.


description: Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA.


description: Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+ = 2,3-dihydroxybenzoate + H+ + NADH.


description: Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP + holo-[ACP] = 2,3-dihydroxybenzoyl-[ACP] + AMP + diphosphate.


name: 2,4-dienoyl-CoA reductase (NADPH) activity

description: Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.


description: Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+.


description: Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde.


2-dehydro-3-deoxygluconokinase activity

description: Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+.


description: Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate.


description: Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate.


description: Catalysis of the reaction: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H+ + phosphate.


2-dehydropantoate 2-reductase activity

description: Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH.


description: Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+.


description: Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+.


description: Catalysis of the reaction: 2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP+.


description: Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O.


2-oxoglutarate decarboxylase activity

description: Catalysis of the reaction: 2-oxoglutarate + H+ = CO2 + succinate semialdehyde.


2-oxopent-4-enoate hydratase activity

description: Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O.


name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity

description: Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP.


description: Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+.


description: Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H+.


description: Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O.


description: Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.


description: Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+.


3-hydroxybutyryl-CoA epimerase activity

description: Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.


description: Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O.


description: Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2.


3-phenylpropionate dioxygenase activity

description: Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol.


description: Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate.


description: Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate.


description: Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.


description: Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.


description: Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH.


description: Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate.


methionine synthase activity

description: Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.


6-phospho-beta-glucosidase activity

description: Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose.


4-phytase activity

description: Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate.


cholate 7-alpha-dehydrogenase activity

description: Catalysis of the reaction: cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H+ + NADH.


description: Catalysis of the reaction: L-alanine + H+ + pimelyl-CoA = 8-amino-7-oxononanoate + CO2 + CoA.


description: Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose.


description: Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+.


AMP nucleosidase activity

description: Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine.


description: Catalysis of the reaction: CDP-diacylglycerol + H2O = a phosphatidate + CMP + 2 H+.


D-alanine-D-alanine ligase activity

description: Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H+ + phosphate.


D-amino-acid dehydrogenase activity

description: Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor.


name: dihydroneopterin triphosphate 2'-epimerase activity

description: Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate.


D-lactate dehydrogenase activity

description: Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate.


D-serine ammonia-lyase activity

description: Catalysis of the reaction: D-serine = pyruvate + NH3.


description: Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.


alkanesulfonate monooxygenase activity

description: Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN.


GDP-mannose mannosyl hydrolase activity

description: Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+.


GTP diphosphokinase activity

description: Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.


L(+)-tartrate dehydratase activity

description: Catalysis of the reaction: L-tartrate = H2O + oxaloacetate.


L-allo-threonine aldolase activity

description: Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde.


L-arabinose isomerase activity

description: Catalysis of the reaction: L-arabinose = L-ribulose.


L-aspartate oxidase activity

description: Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide.


L-carnitine CoA-transferase activity

description: Catalysis of the reactions: (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA and 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA.


L-fucose isomerase activity

description: Catalysis of the reaction: L-fucose = L-fuculose.


L-fuculokinase activity

description: Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H+.


L-fuculose-phosphate aldolase activity

description: Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate.


L-rhamnose isomerase activity

description: Catalysis of the reaction: L-rhamnose = L-rhamnulose.


ribulokinase activity

description: Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate.


description: Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate.


L-threonine 3-dehydrogenase activity

description: Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + CO2 + NADH.


L-xylulokinase activity

description: Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate.


description: Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.


N-acetylneuraminate lyase activity

description: Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.


N-ethylmaleimide reductase activity

description: Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+.


name: proton-translocating NAD(P)+ transhydrogenase activity

description: Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+.


FMN reductase (NAD(P)H) activity

description: Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates.


NADPH dehydrogenase (quinone) activity

description: Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol.


O antigen ligase activity

description: Catalysis of the reaction: Lipid A-core + colanic acid = MLPS.


O antigen polymerase activity

description: Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide.


o-succinylbenzoate-CoA ligase activity

description: Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate.


description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.


description: Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP.


name: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity

description: Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine.


description: Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine.


description: Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+.


description: Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanine.


description: Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.


description: Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate.


description: Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine.


UDP-galactopyranose mutase activity

description: Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose.


UDP-sugar diphosphatase activity

description: Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate.


description: Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein.


name: [citrate (pro-3S)-lyase] ligase activity

description: Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form).


name: [isocitrate dehydrogenase (NADP+)] kinase activity

description: Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate.


description: Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII).


name: acetaldehyde dehydrogenase (acetylating) activity

description: Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+.


acetate CoA-transferase activity

description: Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.


acetate kinase activity

description: Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate.


acetylornithine deacetylase activity

description: Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.


description: Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.


description: Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine.


description: Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.


description: Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine.


agmatinase activity

description: Catalysis of the reaction: agmatine + H2O = putrescine + urea.


alanine racemase activity

description: Catalysis of the reaction: L-alanine = D-alanine.


alkyl hydroperoxide reductase activity

description: Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol.


D-allose 6-phosphate isomerase activity

description: Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate.


D-allose kinase activity

description: Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate.


alpha,alpha-phosphotrehalase activity

description: Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate.


altronate dehydratase activity

description: Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O.


arabinose isomerase activity

description: Catalysis of the reaction: D-arabinose = D-ribulose.


arginine N-succinyltransferase activity

description: Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine.


arginine decarboxylase activity

description: Catalysis of the reaction: L-arginine + H+ = agmatine + CO2.


description: Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.


name: arsenate reductase (glutaredoxin) activity

description: Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.


NAD+ synthase activity

description: Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+.


description: Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides.


aspartate ammonia-lyase activity

description: Catalysis of the reaction: L-aspartate = fumarate + NH3.


beta-aspartyl-peptidase activity

description: Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide.


beta-lactamase activity

description: Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid.


beta-phosphoglucomutase activity

description: Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate.


betaine-aldehyde dehydrogenase activity

description: Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+.


description: Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+.


carbamate kinase activity

description: Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate.


carbon-monoxide oxygenase activity

description: Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561.


carboxymethylenebutenolidase activity

description: Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate.


description: Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2.


cardiolipin synthase activity

description: Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.


carnitine racemase activity

description: Catalysis of the reaction: D-carnitine = L-carnitine.


cellulase activity

description: Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.


description: Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA.


choline dehydrogenase activity

description: Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde.


chorismate lyase activity

description: Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate.


citrate CoA-transferase activity

description: Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA.


citrate (pro-3S)-lyase activity

description: Catalysis of the reaction: citrate = acetate + oxaloacetate.


citryl-CoA lyase activity

description: Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate.


corrinoid adenosyltransferase activity

description: Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin.


name: cobalamin 5'-phosphate synthase activity

description: Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP.


cobinamide kinase activity

description: Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate.


name: cobinamide phosphate guanylyltransferase activity

description: Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate.


name: crossover junction DNA endonuclease activity

description: Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).


cupric reductase activity

description: Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.


cyanate hydratase activity

description: Catalysis of the reaction: cyanate + H2O = carbamate.


description: Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


cysteine sulfinate desulfinase activity

description: Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite.


dATP diphosphatase activity

description: Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate.


dCTP deaminase activity

description: Catalysis of the reaction: dCTP + H2O = dUTP + NH3.


description: Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose.


description: Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH.


dGTPase activity

description: Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate.


name: deoxyribonuclease IV (phage-T4-induced) activity

description: Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.


description: Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate.


description: Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O + H+ = 5-amino-6-(5-phosphoribosylamino)uracil + NH4.


diaminopimelate decarboxylase activity

description: Catalysis of the reaction: meso-2,6-diaminopimelate + H+ = L-lysine + CO2.


diaminopimelate epimerase activity

description: Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate.


description: Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3.


description: Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+.


description: Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O.


dihydrofolate synthase activity

description: Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate.


name: diphosphate-purine nucleoside kinase activity

description: Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide.


endochitinase activity

description: Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain.


Enterobacter ribonuclease activity

description: Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.


enterochelin esterase activity

description: Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+.


ethanolamine ammonia-lyase activity

description: Catalysis of the reaction: ethanolamine = acetaldehyde + NH3.


exodeoxyribonuclease V activity

description: Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides.


exodeoxyribonuclease VII activity

description: Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides.


exoribonuclease II activity

description: Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction.


ferredoxin-NAD+ reductase activity

description: Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+.


formate C-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate.


formate dehydrogenase (NAD+) activity

description: Catalysis of the reaction: formate + NAD+ = CO2 + NADH.


description: Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+.


fructokinase activity

description: Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate.


fructuronate reductase activity

description: Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + H+ + NADH.


galactarate dehydratase activity

description: Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O.


description: Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+.


galactonate dehydratase activity

description: Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O.


description: Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside.


description: Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside.


glucarate dehydratase activity

description: Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O.


gluconate 2-dehydrogenase activity

description: Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+.


gluconate 5-dehydrogenase activity

description: Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+.


gluconate dehydrogenase activity

description: Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+.


name: quinoprotein glucose dehydrogenase activity

description: Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol.


glucose-1-phosphatase activity

description: Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate.


description: Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate.


description: Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose.


glucuronate isomerase activity

description: Catalysis of the reaction: D-glucuronate = D-fructuronate.


glutamate racemase activity

description: Catalysis of the reaction: L-glutamate = D-glutamate.


description: Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].


glutamyl-tRNA reductase activity

description: Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH.


glutathionylspermidine amidase activity

description: Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine.


description: Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate.


name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity

description: Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H2O + NADP+ = 3-phospho-D-glycerate + 2 H+ + NADPH.


glycerate kinase activity

description: Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+.


glycerol dehydrogenase (NAD+) activity

description: Catalysis of the reaction: glycerol + NAD+ = glycerone + H+ + NADH.


description: Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.


glycine C-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA.


guanine deaminase activity

description: Catalysis of the reaction: guanine + H2O = xanthine + NH3.


description: Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H+.


description: Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate.


description: Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.


description: Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.


description: Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA.


name: P-type potassium:proton transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).


ferredoxin hydrogenase activity

description: Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2.


hydroxymethylpyrimidine kinase activity

description: Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H+.


hydroxypyruvate isomerase activity

description: Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate.


description: Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H+.


inosine kinase activity

description: Catalysis of the reaction: ATP + inosine = ADP + IMP.


integrase activity

description: Catalysis of the integration of one DNA segment into another.


isochorismatase activity

description: Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate.


isochorismate synthase activity

description: Catalysis of the reaction: chorismate = isochorismate.


kanamycin kinase activity

description: Catalysis of the reaction: ATP + kanamycin = ADP + 2 H+ + kanamycin 3'-phosphate.


lactaldehyde dehydrogenase activity

description: Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+.


lactaldehyde reductase activity

description: Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+.


lauroyltransferase activity

description: Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another.


description: Catalysis of the reaction: L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H+ + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu). Can also transfer the leucyl residue on an N-terminal L-lysyl residue.


lipid-A-disaccharide synthase activity

description: Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H+ + UDP.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide.


description: Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide.


name: lipopolysaccharide glucosyltransferase I activity

description: Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide.


description: Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+.


description: Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide.


name: long-chain fatty acid [acyl-carrier-protein] ligase activity

description: Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


lysine decarboxylase activity

description: Catalysis of the reaction: L-lysine + H+ = cadaverine + CO2.


malate dehydrogenase (quinone) activity

description: Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol.


maltose O-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose.


description: Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+.


mannonate dehydratase activity

description: Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.


name: mannose-1-phosphate guanylyltransferase (GDP) activity

description: Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H+ = GDP-alpha-D-mannose + phosphate.


methylglyoxal synthase activity

description: Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate.


description: Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose.


lytic endotransglycosylase activity

description: Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends.


lytic transglycosylase activity

description: Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues.


name: inositol monophosphate 1-phosphatase activity

description: Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate.


description: Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O.


nicotinamidase activity

description: Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3.


ferredoxin-NAD(P) reductase activity

description: Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+.


nicotinate N-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine.


description: Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate.


nitrate reductase activity

description: Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor.


name: nitric oxide dioxygenase NAD(P)H activity

description: Catalysis of the reaction: 2 NO + 2 O2 + NAD(P)H + H+ = 2 nitrate + NAD(P)+.


nitrite reductase [NAD(P)H] activity

description: Catalysis of the reaction: NH4+ + 3 NAD(P)+ + 2 H2O = nitrite + 3 NAD(P)H + 5 H+.


oligonucleotidase activity

description: Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates.


oxaloacetate decarboxylase activity

description: Catalysis of the reaction: oxaloacetate = pyruvate + CO2.


oxalyl-CoA decarboxylase activity

description: Catalysis of the reaction: H+ + oxalyl-CoA = CO2 + formyl-CoA.


name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity

description: Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein].


penicillin amidase activity

description: Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate.


description: Catalysis of the reaction: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+.


description: Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+.


phosphate acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate.


description: Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose.


name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity

description: Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein.


phosphatidylglycerophosphatase activity

description: Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.


description: Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol.


description: Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-.


description: Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.


phosphoglucosamine mutase activity

description: Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.


phosphoglycolate phosphatase activity

description: Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate.


name: D-sedoheptulose 7-phosphate isomerase activity

description: Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate.


phospholipase A1 activity

description: Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.


phosphomethylpyrimidine kinase activity

description: Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.


phosphopentomutase activity

description: Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate.


phosphoribulokinase activity

description: Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H+.


polyphosphate kinase activity

description: Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1).


name: prephenate dehydrogenase (NAD+) activity

description: Catalysis of the reaction: NAD+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADH.


prophage integrase activity

description: Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA.


propionate kinase activity

description: Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate.