metanephric mesenchyme development

description: The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros.


nephrogenic mesenchyme development

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron.


renal vesicle morphogenesis

description: The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells.


nephron tubule morphogenesis

description: The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney.


nephron tubule formation

description: The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney.


nephron tubule development

description: The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney.


name: specification of nephron tubule identity

description: The process in which the tubules arranged along the proximal/distal axis of the nephron acquire their identity.


name: specification of proximal tubule identity

description: The process in which the proximal tubule of the kidney nephron acquires its identity.


specification of distal tubule identity

description: The process in which the distal tubule of the kidney nephron acquires its identity.


name: specification of connecting tubule identity

description: The process in which the connecting tubule of the kidney nephron acquires its identity.


specification of loop of Henle identity

description: The process in which the loop of Henle of the kidney nephron acquires its identity.


renal vesicle development

description: The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells.


nephron epithelium morphogenesis

description: The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron.


stem cell proliferation

description: The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.


name: mesenchymal stem cell proliferation involved in nephron morphogenesis

description: The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron.


regulation of stem cell proliferation

description: Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.


ureteric bud invasion

description: The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros.


metanephric renal vesicle formation

description: The developmental process pertaining to the initial formation of the metanephros.


metanephric renal vesicle induction

description: Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the metanephric renal vesicle.


name: regulation of branch elongation involved in ureteric bud branching

description: Any process that modulates the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis.


name: negative regulation of branch elongation involved in ureteric bud branching

description: Any process that reduces the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis.


name: anterior/posterior pattern specification involved in kidney development

description: The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate.


name: anterior/posterior pattern specification involved in ureteric bud development

description: The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate.


name: specification of ureteric bud anterior/posterior symmetry

description: The establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis.


glomerulus morphogenesis

description: The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


glomerulus vasculature morphogenesis

description: The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus.


glomerular capillary formation

description: The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.


ureteric peristalsis

description: A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder.


regulation of ureteric bud formation

description: Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct.


name: positive regulation of ureteric bud formation

description: Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct.


name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

description: Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.


glomerular mesangium development

description: The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus.


glomerular mesangial cell proliferation

description: The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population.


name: cell proliferation involved in kidney development

description: The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney.


podocyte differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells.


head kidney development

description: The process whose specific outcome is the progression of the head kidney over time, from its formation to the mature structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. It is analogous to the mammalian bone marrow and the primary site of definitive hematopoiesis.


pronephros morphogenesis

description: The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.


head kidney morphogenesis

description: The process in which the anatomical structures of the head kidney are generated and organized. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney.


pronephros formation

description: The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.


head kidney formation

description: The developmental process pertaining to the initial formation of the head kidney. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney.


pronephros structural organization

description: The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.


head kidney structural organization

description: The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney.


pronephros maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.


head kidney maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the head kidney to attain its fully functional state. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney.


name: extraglomerular mesangial cell proliferation

description: The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa.


name: intraglomerular mesangial cell proliferation

description: The multiplication or reproduction of intraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis.


name: regulation of glomerular mesangial cell proliferation

description: Any process that modulates the frequency, rate or extent of glomerular mesangial cell proliferation.


name: negative regulation of glomerular mesangial cell proliferation

description: Any process that decreases the frequency, rate or extent of glomerular mesangial cell proliferation.


name: positive regulation of glomerular mesangial cell proliferation

description: Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation.


renal capsule development

description: The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands.


renal capsule morphogenesis

description: The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands.


renal capsule formation

description: The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands.


renal capsule specification

description: The regionalization process in which the identity of the renal capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


kidney mesenchyme morphogenesis

description: The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney.


mesenchyme morphogenesis

description: The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells.


metanephric mesenchyme morphogenesis

description: The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros.


nephrogenic mesenchyme morphogenesis

description: The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron.


kidney mesenchymal cell proliferation

description: The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population in the kidney.


name: metanephric mesenchymal cell proliferation involved in metanephros development

description: The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population.


name: condensed mesenchymal cell proliferation

description: The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells.


name: mesenchymal cell proliferation involved in ureteric bud development

description: The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development.


name: glomerular parietal epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport.


DCT cell development

description: The process whose specific outcome is the progression of a distal convoluted tubule cell over time, from its formation to the mature structure.


name: renal interstitial fibroblast development

description: The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure.


juxtaglomerulus cell development

description: The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure.


mesangial cell development

description: The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure.


glomerular mesangial cell development

description: The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure.


name: proximal convoluted tubule segment 1 cell development

description: The process whose specific outcome is the progression of an S1 cell in the kidney over time, from its formation to the mature structure.


DCT cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell.


name: glomerular parietal epithelial cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes.


epithelial cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell.


podocyte cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells.


juxtaglomerulus cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a juxtaglomerulus cell.


mesangial cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesangial cell.


name: glomerular mesangial cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell.


name: renal interstitial fibroblast fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a renal fibroblast.


name: proximal convoluted tubule segment 1 cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney.


name: epithelial cell migration involved in nephron tubule morphogenesis

description: The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis.


distal tubule morphogenesis

description: The process in which the anatomical structures of a distal tubule are generated and organized. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule.


name: epithelial cell migration involved in distal tubule morphogenesis

description: The orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis.


proximal tubule morphogenesis

description: The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology.


name: epithelial cell migration involved in proximal tubule morphogenesis

description: The orderly movement of epithelial cells within a renal tubule that contributes to proximal tubule morphogenesis.


name: nephron tubule epithelial cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state.


name: mesenchymal cell differentiation involved in kidney development

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state.


name: metanephric mesenchymal cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state.


mesonephric epithelium development

description: The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.


mesonephric tubule development

description: The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros.


anterior mesonephric tubule development

description: The progression of the anterior mesonephric tubule over time, from its initial formation to the mature structure. The anterior mesonephric tubule is an epithelial tube that is part of the mesonephros.


name: posterior mesonephric tubule development

description: The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros.


name: specification of mesonephric tubule identity

description: The process in which the tubules of the mesonephros acquire their identity.


name: specification of anterior mesonephric tubule identity

description: The process in which the tubules of the anterior mesonephros acquire their identity.


name: specification of posterior mesonephric tubule identity

description: The process in which the tubules of the posterior mesonephros acquire their identity.


metanephric tubule development

description: The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros.


mesonephric tubule morphogenesis

description: The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros.


mesonephric tubule formation

description: The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros.


metanephric tubule morphogenesis

description: The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros.


metanephric tubule formation

description: The developmental process pertaining to the initial formation of a metanephric tubule.


epithelial tube formation

description: The developmental process pertaining to the initial formation of an epithelial tube.


nephric duct development

description: The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney.


mesonephric duct development

description: The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros.


nephric duct morphogenesis

description: The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney.


nephric duct formation

description: The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney.


mesonephric duct morphogenesis

description: The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros.


mesonephric duct formation

description: The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube that drains the mesonephros.


name: regulation of nephron tubule epithelial cell differentiation

description: Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation.


name: negative regulation of nephron tubule epithelial cell differentiation

description: Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation.


name: renal vesicle progenitor cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing.


metanephric cap development

description: The biological process whose specific outcome is the progression of the metanephric cap from an initial condition to its mature state. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip.


metanephric cap morphogenesis

description: The process in which the anatomical structures of the metanephric cap are generated and organized. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip.


metanephric cap formation

description: The developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip.


metanephric cap specification

description: The process in which the metanephric cap acquires its identity.


ureter development

description: The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.


ureter urothelium development

description: The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter.


ureter smooth muscle development

description: The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure.


ureter epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter.


name: ureter smooth muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter.


kidney smooth muscle tissue development

description: The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure.


name: kidney smooth muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the kidney.


name: proximal/distal pattern formation involved in pronephric nephron development

description: The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros.


ureter morphogenesis

description: The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder.


name: mesenchymal cell proliferation involved in ureter development

description: The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development.


name: regulation of mesenchymal cell proliferation involved in ureter development

description: Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


name: negative regulation of mesenchymal cell proliferation involved in ureter development

description: Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


name: negative regulation of mesenchymal cell proliferation

description: Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


name: cell differentiation involved in metanephros development

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state.


name: cell proliferation involved in metanephros development

description: The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros.


name: cell-cell signaling involved in metanephros development

description: Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ.


metanephric collecting duct development

description: The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder.


name: metanephric juxtaglomerular apparatus development

description: The process whose specific outcome is the progression of the juxtaglomerular apparatus in the metanephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate.


metanephric epithelium development

description: The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.


name: metanephric smooth muscle tissue development

description: The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure.


name: metanephric mesangial cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the metanephros as it progresses from its formation to the mature state.


metanephric nephron development

description: The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.


metanephric pyramids development

description: The process whose specific outcome is the progression of the metanephric pyramids over time, from their formation to the mature structures. Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts.


metanephric capsule development

description: The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage.


metanephric cortex development

description: The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros.


regulation of metanephros development

description: Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.


name: positive regulation of metanephros development

description: Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


name: negative regulation of metanephros development

description: Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


name: metanephric ascending thin limb development

description: The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent.


name: metanephric cortical collecting duct development

description: The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex.


name: metanephric descending thin limb development

description: The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle.


name: metanephric distal convoluted tubule development

description: The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter.


name: metanephric early distal convoluted tubule development

description: The process whose specific outcome is the progression of the metanephric early distal convoluted tubule over time, from its formation to the mature structure. The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive.


name: metanephric glomerular mesangium development

description: The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus.


metanephric glomerulus development

description: The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros.


name: metanephric late distal convoluted tubule development

description: The process whose specific outcome is the progression of the metanephric late distal convoluted tubule over time, from its formation to the mature structure. The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive.


name: metanephric long descending thin limb bend development

description: The process whose specific outcome is the progression of the metanephric long descending thin limb bend over time, from its formation to the mature structure. The metanephric long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment in the metanephros.


metanephric macula densa development

description: The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus.


metanephric prebend segment development

description: The process whose specific outcome is the progression of the metanephric prebend segment over time, from its formation to the mature structure. The metanephric prebend segment is a part of the metanephric descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability.


name: metanephric proximal convoluted tubule development

description: The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule.


name: metanephric proximal straight tubule development

description: The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule.


name: metanephric proximal convoluted tubule segment 1 development

description: The process whose specific outcome is the progression of the S1 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes.


name: metanephric proximal convoluted tubule segment 2 development

description: The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride.


name: metanephric thick ascending limb development

description: The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule.


metanephric nephron tubule development

description: The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros.


metanephric distal tubule development

description: The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule.


metanephric loop of Henle development

description: The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros.


metanephric proximal tubule development

description: The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology.


metanephric long nephron development

description: The process whose specific outcome is the progression of a metanephric long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros.


name: metanephric glomerulus vasculature development

description: The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus.


metanephric DCT cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state.


metanephric DCT cell development

description: The process whose specific outcome is the progression of a metanephric distal convoluted tubule cell over time, from its formation to the mature structure.


metanephric DCT cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric distal convoluted tubule cell.


name: metanephric nephron epithelium development

description: The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros.


name: metanephric glomerular epithelium development

description: The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.


name: metanephric glomerular parietal epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport.


name: metanephric glomerular parietal epithelial cell development

description: The process whose specific outcome is the progression of a metanephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport.


name: metanephric glomerular parietal epithelial cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes.


metanephric podocyte differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.


metanephric podocyte development

description: The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.


name: metanephric podocyte cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.


name: metanephric juxtaglomerulus cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the metanephros as it progresses from its formation to the mature state.


name: metanephric juxtaglomerulus cell development

description: The process whose specific outcome is the progression of a metanephric juxtaglomerulus cell over time, from its formation to the mature structure.


name: metanephric juxtaglomerulus cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric juxtaglomerulus cell.


name: metanephric glomerular mesangial cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state.


name: metanephric glomerular mesangial cell development

description: The process whose specific outcome is the progression of a glomerular mesangial cell in the metanephros over time, from its formation to the mature structure.


name: metanephric glomerular mesangial cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular mesangial cell.


name: metanephric nephron tubule epithelial cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state.


name: metanephric interstitial fibroblast differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the metanephros as it progresses from its formation to the mature state.


name: metanephric interstitial fibroblast development

description: The process whose specific outcome is the progression of a metanephric interstitial fibroblast over time, from its formation to the mature structure.


name: metanephric interstitial fibroblast fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric interstitial fibroblast.


name: metanephric extraglomerular mesangial cell proliferation involved in metanephros development

description: The multiplication or reproduction of extraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa.


name: metanephric glomerular mesangial cell proliferation involved in metanephros development

description: The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population.


name: metanephric intraglomerular mesangial cell proliferation

description: The multiplication or reproduction of intraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis.


name: metanephric glomerular endothelium development

description: The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros.


metanephric capsule morphogenesis

description: The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage.


metanephric capsule formation

description: The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage.


metanephric capsule specification

description: The regionalization process in which the identity of the metanephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


name: pattern specification involved in metanephros development

description: Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate.


name: metanephric long descending thin limb development

description: The process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla.


metanephric short nephron development

description: The process whose specific outcome is the progression of a short nephron in the metanephros over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb.


name: metanephric short descending thin limb development

description: The process whose specific outcome is the progression of the metanephric short descending thin limb over time, from its formation to the mature structure. The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology.


name: proximal/distal pattern formation involved in metanephric nephron development

description: The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end).


metanephric nephron morphogenesis

description: The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros.


name: metanephric glomerular basement membrane development

description: The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration.


metanephric glomerulus morphogenesis

description: The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros.


name: metanephric glomerulus vasculature morphogenesis

description: The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus.


name: metanephric glomerular capillary formation

description: The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.


name: metanephric comma-shaped body morphogenesis

description: The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros.


name: convergent extension involved in metanephric nephron morphogenesis

description: The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the metanephros.


name: establishment of planar polarity involved in metanephric nephron morphogenesis

description: Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the metanephros.


name: mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis

description: The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


name: metanephric nephron tubule morphogenesis

description: The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros.


metanephric renal vesicle morphogenesis

description: The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells.


metanephric S-shaped body morphogenesis

description: The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.


name: mesenchymal to epithelial transition involved in metanephric renal vesicle formation

description: A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle.


name: metanephric connecting tubule development

description: The process whose specific outcome is the progression of the metanephric connecting tubule over time, from its formation to the mature structure. The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros.


metanephric distal tubule morphogenesis

description: The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule.


name: metanephric proximal tubule morphogenesis

description: The process in which the anatomical structures of a metanephric proximal tubule are generated and organized. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology.


metanephric nephron tubule formation

description: The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros.


name: epithelial cell migration involved in metanephric nephron tubule morphogenesis

description: The orderly movement of epithelial cells within a renal tubule that contributes to metanephric nephron tubule morphogenesis.


name: epithelial cell migration involved in metanephric distal tubule morphogenesis

description: The orderly movement of epithelial cells within a renal tubule that contributes to metanephric distal tubule morphogenesis.


name: epithelial cell migration involved in metanephric proximal tubule morphogenesis

description: The orderly movement of epithelial cells within a renal tubule that contributes to metanephric proximal tubule morphogenesis.


name: specification of metanephric nephron tubule identity

description: The process in which the tubules arranged along the proximal/distal axis of the metanephric nephron acquire their identity.


name: specification of metanephric connecting tubule identity

description: The process in which the connecting tubule of the metanephric nephron acquires its identity.


name: specification of metanephric distal tubule identity

description: The process in which the distal tubule of the metanephric nephron acquires its identity.


name: specification of metanephric loop of Henle identity

description: The process in which the loop of Henle of the metanephric nephron acquires its identity.


name: specification of metanephric proximal tubule identity

description: The process in which the proximal tubule of the metanephric nephron acquires its identity.


name: regulation of metanephric glomerulus development

description: Any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros.


name: negative regulation of metanephric glomerulus development

description: Any process that decreases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros.


name: positive regulation of metanephric glomerulus development

description: Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros.


name: regulation of metanephric glomerular mesangial cell proliferation

description: Any process that modulates the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.


name: negative regulation of metanephric glomerular mesangial cell proliferation

description: Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.


name: positive regulation of glomerular metanephric mesangial cell proliferation

description: Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.


name: regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

description: Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros.


name: negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

description: Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros.


name: positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

description: Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros.


name: regulation of metanephric nephron tubule epithelial cell differentiation

description: Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation.


name: negative regulation of metanephric nephron tubule epithelial cell differentiation

description: Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation.


name: mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis

description: The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


glomerular epithelial cell development

description: The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells.


name: glomerular epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells.


name: metanephric glomerular epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells.


name: metanephric glomerular epithelial cell development

description: The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells.


name: glomerular epithelial cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells.


name: metanephric glomerular epithelial cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells.


name: alpha-glucan catabolic process involved in ascospore release from ascus

description: The chemical reactions and pathways resulting in the breakdown of alpha-glucans in the ascus wall that contributes to the release of ascospores from the ascus.


clathrin coat disassembly

description: The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system.


vesicle uncoating

description: A protein depolymerization process that results in the disassembly of vesicle coat proteins.


name: volume-sensitive chloride channel activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.


name: protein transport across periplasmic space

description: The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane or cell wall.


ascus epiplasm

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Ascus cytoplasm that is not packaged into ascospores.


vulval cell fate commitment

description: The process in which the cellular identity of nematode vulval cells is acquired and determined. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes.


vulval cell fate determination

description: The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell regardless of its environment; upon determination, the cell fate cannot be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes.


vulval cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes.


alkene binding

description: Binding to an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n.


monocarboxylic acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.


name: monocarboxylic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.


name: signal transduction by p53 class mediator

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein.


name: intrinsic apoptotic signaling pathway by p53 class mediator

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.


UDP-galactose transmembrane transport

description: The process in which UDP-galactose is transported across a membrane.


modified amino acid transport

description: The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


lactam metabolic process

description: The chemical reactions and pathways involving lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.


lactam biosynthetic process

description: The chemical reactions and pathways resulting in the formation of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.


lactam catabolic process

description: The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.


modified amino acid binding

description: Binding to a modified amino acid.


response to anion stress

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of anion stress, an increase or decrease in the concentration of negatively charged ions in the environment.


pancreatic stellate cell proliferation

description: The multiplication or reproduction of pancreatic stellate cells, resulting in the expansion of a pancreatic stellate cell population. Pancreatic stellate cells are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and have long cytoplasmic processes that encircle the base of the acinus.


rescue of stalled ribosome

description: A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.


name: NAADP-sensitive calcium-release channel activity

description: Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts.


name: cADPR-sensitive calcium-release channel activity

description: Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts.


response to anesthetic

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation.


sulfur compound transport

description: The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: modified amino acid transmembrane transporter activity

description: Enables the transfer of modified amino acids from one side of a membrane to the other.


tricarboxylic acid metabolic process

description: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).


tricarboxylic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups.


tricarboxylic acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups.


histone H3T3 kinase activity

description: Catalysis of the reaction: histone H3-threonine (position 3) + ATP = histone H3-phosphothreonine (position 3) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 3 of histone H3.


name: chromosome passenger complex localization to kinetochore

description: A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis.


PTW/PP1 phosphatase complex

description: A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.


circulatory system development

description: The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.


vascular cord development

description: The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis.


histone H2AS121 kinase activity

description: Catalysis of the reaction: histone H2A-serine (position 121) + ATP = histone H2A-phosphoserine (position 121) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 121 of histone H2A.


name: alpha-carotene epsilon hydroxylase activity

description: Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O.


carotene epsilon hydroxylase activity

description: Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene.


medium-term memory

description: The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).


protein activation cascade

description: A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events.


blood coagulation, common pathway

description: A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex.


name: blood coagulation, fibrin clot formation

description: A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.


ER membrane insertion complex

description: A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast.


TRC complex

description: A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane.


name: minus-end-directed vesicle transport along microtubule

description: The directed movement of a vesicle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.


name: plus-end-directed vesicle transport along microtubule

description: The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.


organelle transport along microtubule

description: The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.


name: minus-end-directed organelle transport along microtubule

description: The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.


name: plus-end-directed organelle transport along microtubule

description: The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.


name: flavin adenine dinucleotide metabolic process

description: The chemical reactions and pathways involving flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.


name: flavin adenine dinucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.


name: flavin adenine dinucleotide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes.


phenol metabolic process

description: The chemical reactions and pathways involving phenol, a compound that consists of a benzene ring with one attached hydroxyl group.


phenol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group.


phenol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phenol, a compound that consists of a benzene ring with one attached hydroxyl group.


name: microtubule anchoring at microtubule organizing center

description: Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center.


name: response to cell cycle checkpoint signaling

description: A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling.


name: signal transduction involved in cytokinesis checkpoint

description: A signal transduction process that contributes to a cytokinesis checkpoint.


name: response to cytokinesis checkpoint signaling

description: A process that occurs in response to signals generated as a result of cytokinesis checkpoint signaling.


name: response to DNA integrity checkpoint signaling

description: A process that occurs in response to signals generated as a result of DNA integrity checkpoint signaling.


name: response to meiotic cell cycle checkpoint signaling

description: A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint.


name: response to mitotic cell cycle checkpoint signaling

description: A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling.


name: response to spindle checkpoint signaling

description: A process that occurs in response to signals generated as a result of spindle checkpoint signaling.


name: response to DNA damage checkpoint signaling

description: A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling.


name: response to G2 DNA damage checkpoint signaling

description: A process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling.


name: response to intra-S DNA damage checkpoint signaling

description: A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling.


name: response to G1 DNA damage checkpoint signaling

description: A process that occurs in response to signals generated as a result of G1/S transition DNA damage checkpoint signaling.


name: response to mitotic G2 DNA damage checkpoint signaling

description: A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling.


name: response to DNA replication checkpoint signaling

description: A process that occurs in response to signals generated as a result of DNA replication checkpoint signaling.


name: response to meiotic DNA replication checkpoint signaling

description: A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling.


name: response to mitotic DNA replication checkpoint signaling

description: A process that occurs in response to signals generated as a result of mitotic DNA replication checkpoint signaling.


name: response to G1 cell size control checkpoint signaling

description: A process that occurs in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling.


name: response to G2 transition size control checkpoint signaling

description: A process that occurs in response to signals generated as a result of G2/M transition size control checkpoint signaling.


name: response to meiotic recombination checkpoint signaling

description: A process that occurs in response to signals generated as a result of meiotic recombination checkpoint signaling.


name: response to meiotic spindle assembly checkpoint signaling

description: A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling.


name: response to cell size control checkpoint signaling

description: A process that occurs in response to signals generated as a result of cell size control checkpoint signaling.


name: response to mitotic spindle checkpoint signaling

description: A process that occurs in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling.


name: response to mitotic cell cycle spindle assembly checkpoint signaling

description: A process that occurs in response to signals generated as a result of mitotic cell cycle spindle assembly checkpoint signaling.


name: response to mitotic cell cycle spindle orientation checkpoint signaling

description: A process that occurs in response to signals generated as a result of mitotic cell cycle spindle orientation checkpoint signaling.


name: response to spindle assembly checkpoint signaling

description: A process that occurs in response to signals generated as a result of spindle assembly checkpoint signaling.


MSL complex

description: A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.


ammonium transmembrane transport

description: The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+.


methylammonium transmembrane transport

description: The process in which methylammonium is transported across a membrane.


name: toluene-containing compound metabolic process

description: The chemical reactions and pathways involving toluene, methylbenzene (formula C7H8), or any of its derivatives.


name: toluene-containing compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of toluene, methylbenzene (formula C7H8), or any of its derivatives.


name: host cell mitochondrial intermembrane space

description: The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope.


host cell endosome lumen

description: The volume enclosed by the membranes of the host cell endosome.


host multivesicular body

description: A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm.


host cell Cajal body

description: A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction.


Pup transferase activity

description: Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages.


mesenchymal stem cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


embryonic skeletal joint development

description: The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure.


photoreceptor cell axon guidance

description: The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues.


name: positive regulation of secondary heart field cardioblast proliferation

description: Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).


name: trehalose transport in response to water deprivation

description: The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of deprivation of water.


name: trehalose transport in response to desiccation

description: The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of a desiccation stimulus. A desiccation stimulus signals extreme dryness resulting from the prolonged deprivation of water.


host cell viral assembly compartment

description: A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place.


name: Rho-dependent protein serine/threonine kinase activity

description: Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


seminiferous tubule development

description: The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa.


name: purine-containing compound metabolic process

description: The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.


name: purine-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.


name: purine-containing compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.


name: pyridine-containing compound metabolic process

description: The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof.


name: pyridine-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof.


name: pyridine-containing compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof.


name: pyrimidine-containing compound metabolic process

description: The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof.


name: pyrimidine-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof.


name: pyrimidine-containing compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof.


name: purine-containing compound transmembrane transport

description: The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof.


name: pyrimidine-containing compound transmembrane transport

description: The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof.


name: tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity

description: Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives.


name: tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity

description: Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives.


perineuronal net

description: A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain.


name: tumor necrosis factor (ligand) superfamily member 11 production

description: The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


interleukin-23 receptor complex

description: A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.


fibroblast activation

description: A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.