name: negative regulation of animal organ morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis.


name: regulation of lipid transporter activity

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the frequency, rate, or extent of lipid transporter activity.


name: positive regulation of lipid transporter activity

description: Any process that increases the frequency, rate, or extent of lipid transporter activity.


name: negative regulation of lipid transporter activity

description: Any process that decreases the frequency, rate, or extent of lipid transporter activity.


Cdr2 medial cortical node complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A megadalton-sized complex at the medial cortex organized as an oligomeric core of SAD family protein kinases involved in cell size-dependent localization and phosphorylation of Wee1 during interphase.


name: regulation of compound eye photoreceptor cell differentiation

description: Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation.


name: positive regulation of compound eye photoreceptor cell differentiation

description: Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation.


name: negative regulation of compound eye photoreceptor cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation.


name: positive regulation of very-low-density lipoprotein particle clearance

description: Any process that increases the frequency, rate or extent of very-low-density lipoprotein particle clearance.


name: gamma-tubulin complex localization to nuclear side of mitotic spindle pole body

description: Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the nuclear side of the mitotic spindle pole body.


name: gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body

description: Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the cytoplasmic side of the mitotic spindle pole body.


myotube cell migration

description: The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse.


regulation of myotube cell migration

description: Any process that modulates the frequency, rate or extent of myotube cell migration.


name: positive regulation of myotube cell migration

description: Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration.


name: negative regulation of myotube cell migration

description: Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration.


phloem loading

description: The process of loading solutes into the sieve tube or companion cell of the phloem for long distance transport from source to sink.


phloem unloading

description: The process of unloading solutes that are produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues.


phloem sucrose unloading

description: The process of unloading sucrose that is produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues.


ribitol-5-phosphatase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate.


Aim21-Tda2 complex

description: A complex that localizes to actin cortical patches at sites of endocytosis and negatively regulates barbed end F-actin assembly, resulting in the generation of free actin pools. The Aim21-Tda2 complex is necessary for efficient endocytosis and balancing the distribution of actin between patches and cables.


meiotic drive

description: A biological process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes. In the absence of meiotic drive, the two copies of each gene or chromosome in a diploid organism are transmitted to offspring with equal probability, whereas meiotic drive results in overrepresentation of the driving allele among the surviving products of meiosis.


Norrin signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state.


protein-RNA complex remodeling

description: The acquisition, loss, or modification of macromolecules within a protein-RNA complex, resulting in the alteration of an existing complex.


name: regulation of imaginal disc-derived leg joint morphogenesis

description: Any process that modulates the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis, the process in which the anatomical structure of the imaginal disc-derived leg joint is generated and organized.


name: positive regulation of imaginal disc-derived leg joint morphogenesis

description: Any process that activates or increases the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis.


name: negative regulation of imaginal disc-derived leg joint morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis.


flagellum attachment zone organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum attachment zone. FAZ is a network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species.


L-glutamate import into mitochondrion

description: The process in which L-glutamate is transported from the cytosol into the mitochondrial matrix.


ubiquinone biosynthesis complex

description: A protein complex composed of enzymes and accessory factors of the ubiquinone (CoQ) biosynthesis pathway. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K. In eukaryotes, the complex is located on the matrix face of the inner mitochondrial membrane and includes COQ3, COQ4, COQ5, COQ6, COQ7, COQ9.


magnetosome

description: A membrane-bound organelle that envelops particles of magnetic iron minerals in magnetotactic bacteria. Magnetosomes form linear chains that align along the cellular motility axis at midcell and function in bacterial navigation along the Earth's magnetic field. They are formed by invagination of the cell inner membrane; in some species they remain connected to the inner membrane, in others they pinch off to form independent intracellular vesicles.


magnetosome lumen

description: The volume enclosed by the membrane of a magnetosome.


magnetosome membrane

description: The lipid bilayer surrounding a magnetosome.


name: protein maturation by nickel ion transfer

description: A process that contributes to the delivery of nickel ions to a target protein to facilitate its maturation.


name: RNA NAD+-cap (NAD+-forming) hydrolase activity

description: Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H+ + NAD+.


name: RNA NAD-cap (NMN-forming) hydrolase activity

description: Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+.


RNA decapping

description: Cleavage of the 5'-cap of an RNA.


NAD-cap decapping

description: Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes.


mRNA methylguanosine-cap decapping

description: Cleavage of the 5'-methylguanosine-cap of an mRNA. The methylguanosine-cap is present at the 5'-end of eukaryotic mRNAs. Decapping inactivates translation initiation and promotes 5'-to-3' decay of mRNA.


reelin complex

description: An extracellular complex that binds lipoprotein receptors VLDLR and APOER2, cadherin-related neuronal receptors (CNRs) or alpha3beta1 integrin and induces various downstream, reelin-dependent, phosphorylation cascades. It ultimately affects polarization, differentiation, neuronal migration and layer formation in the embryonic brain and neuron growth, maturation, and synaptic activity in the postnatal and adult brain.


calpain complex

description: A calcium-dependent protease complex that processes its substrate by limited proteolysis rather than degrading it. In some cases limited proteolysis is required for the activation of its substrate.


name: regulation of mitotic spindle formation (spindle phase one)

description: Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one).


name: negative regulation of mitotic spindle formation (spindle phase one)

description: Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one).


name: positive regulation of mitotic spindle formation (spindle phase one)

description: Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one).


name: regulation of mitotic spindle elongation (spindle phase three)

description: Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three).


name: negative regulation of mitotic spindle elongation (spindle phase three)

description: Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three).


name: positive regulation of mitotic spindle elongation (spindle phase three)

description: Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three).


cellular anatomical entity

description: A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.


name: DNA synthesis involved in mitochondrial DNA replication

description: Any DNA biosynthetic process that is involved in mitochondrial DNA replication.


name: apical plasma membrane urothelial plaque

description: A scallop-shaped plaque, also referred to as an asymmetric unit membrane (AUM), found in the apical plasma membrane of urothelial superficial (umbrella) cells which form a a barrier to the passage of water and soluble toxic compounds found in urine. The plaques are thickened regions of membrane composed of uroplakin transmembrane proteins which form a crystalline array.


fusiform vesicle

description: A cytoplasmic vesicle which contains two urothelial plaques and can deliver these plaques to the apical plasma membrane of urothelial superficial (umbrella) cells. It can also be formed by endocytosis of apical plasma membrane during contractions of the urinary bladder.


name: hinge region between urothelial plaques of apical plasma membrane

description: A narrow rim of non-thickened membrane in between urothelial plaques in apical plasma membrane.


name: regulation of glutamatergic neuron differentiation

description: Any process that modulates the frequency, rate or extent of glutamatergic neuron differentiation.


name: negative regulation of glutamatergic neuron differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation.


name: positive regulation of glutamatergic neuron differentiation

description: Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation.


intermembrane lipid transfer

description: The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs).


intermembrane phospholipid transfer

description: The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane.


intermembrane sterol transfer

description: The transport of sterols between membranes in which a sterol molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs).


intermembrane sphingolipid transfer

description: The transport of sphingolipids between membranes in which a sphingolipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs).


lipid transfer activity

description: Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids.


phospholipid transfer activity

description: Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


sterol transfer activity

description: Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


sphingolipid transfer activity

description: Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


ceramide transfer activity

description: Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


phosphatidylcholine transfer activity

description: Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


cholesterol transfer activity

description: Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


oxysterol transfer activity

description: Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


glucagon family peptide binding

description: Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP).


somatostatin binding

description: Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin.


plasma membrane bounded cell projection

description: A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.


host cell uropod

description: A host cell membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.


proton export across plasma membrane

description: The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region.


name: positive regulation of cilium beat frequency involved in ciliary motility

description: Any process that activates or increases the frequency of cilium beating involved in ciliary motility.


name: plasma membrane bounded cell projection assembly

description: Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.


name: regulation of plasma membrane bounded cell projection assembly

description: Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly.


name: negative regulation of plasma membrane bounded cell projection assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly.


name: positive regulation of plasma membrane bounded cell projection assembly

description: Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly.


name: regulation of plasma membrane bounded cell projection organization

description: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.


name: plasma membrane bounded cell projection organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon.


name: plasma membrane bounded cell projection morphogenesis

description: The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized.


regulation of macrophage proliferation

description: Any process that modulates the frequency, rate or extent of macrophage proliferation.


name: positive regulation of macrophage proliferation

description: Any process that activates or increases the frequency, rate or extent of macrophage proliferation.


name: negative regulation of macrophage proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage proliferation.


stereocilium shaft

description: The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle.


stereocilium base

description: The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium.


stereocilium maintenance

description: The organization process that preserves a stereocilium in a stable functional or structural state.


name: regulation of protein localization to medial cortical node

description: Any process that modulates the frequency, rate or extent of protein localization to a medial cortical node.


name: positive regulation of protein localization to medial cortical node

description: Any process that activates or increases the frequency, rate or extent of protein localization to a medial cortical node.


name: U6 snRNA (adenine-(43)-N(6))-methyltransferase activity

description: Catalysis of the reaction: adenosine in U6 snRNA + S-adenosyl-L-methionine = H+ + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine.


snRNA (adenine-N6)-methylation

description: The posttranscriptional N6-methylation of an adenine residue in an snRNA molecule.


description: Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R.


intestinal motility

description: Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth).


small intestinal transit

description: Migration of ingested material along the length of the small intestine.


large intestinal transit

description: Migration of ingested material along the length of the large intestine.


regulation of small intestinal transit

description: Any process that modulates the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine.


name: positive regulation of small intestinal transit

description: Any process that increases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine.


name: negative regulation of small intestinal transit

description: Any process that decreases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine.


regulation of gastric emptying

description: Any process that modulates the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum.


negative regulation of gastric emptying

description: Any process that decreases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum.


positive regulation of gastric emptying

description: Any process that increases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum.


stomach smooth muscle contraction

description: A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs throughout the length of the stomach.


name: stomach pylorus smooth muscle contraction

description: A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the most distal part of the stomach.


name: pyloric antrum smooth muscle contraction

description: A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the widest part of the pylorus that is continuous with the body of the stomach.


pyloric canal smooth muscle contraction

description: A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal part of the pylorus between the pyloric antrum and the pyloric sphincter.


name: pyloric sphincter smooth muscle contraction

description: A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the narrowest part of the pylorus that separates the stomach from the duodenum.


name: regulation of stomach fundus smooth muscle contraction

description: Any process that modulates the frequency, rate or extent of any stomach fundus smooth muscle contraction.


name: positive regulation of stomach fundus smooth muscle contraction

description: Any process that increases the frequency, rate or extent of any stomach fundus smooth muscle contraction.


name: negative regulation of stomach fundus smooth muscle contraction

description: Any process that decreases the frequency, rate or extent of any stomach fundus smooth muscle contraction.


name: regulation of pyloric antrum smooth muscle contraction

description: Any process that modulates the frequency, rate or extent of any pyloric antrum smooth muscle contraction.


name: positive regulation of pyloric antrum smooth muscle contraction

description: Any process that increases the frequency, rate or extent of any pyloric antrum smooth muscle contraction.


name: negative regulation of pyloric antrum smooth muscle contraction

description: Any process that decreases the frequency, rate or extent of any pyloric antrum smooth muscle contraction.


name: regulation of endocardial cushion cell differentiation

description: Any process that modulates the frequency, rate or extent of cell differentiation, the process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell.


name: positive regulation of endocardial cushion cell differentiation

description: Any process that activates or increases the frequency, rate or extent of endocardial cushion cell differentiation.


name: negative regulation of endocardial cushion cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of endocardial cushion cell differentiation.


angiogenic sprout fusion

description: The connection of an angiogenic sprout to another vessel or sprout during the formation of vascular networks by sprouting angiogenesis.


name: cell adhesion involved in sprouting angiogenesis

description: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the formation of a blood vessel network.


smooth endoplasmic reticulum cisterna

description: A subcompartment of the smooth endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity.


rough endoplasmic reticulum cisterna

description: A subcompartment of the rough endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity.


name: endothelial tip cell filopodium assembly

description: The assembly of a filopodium, a thin, stiff protrusion extended by the endothelial tip cell of a vascular sprout.


description: Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene.


jasmonic acid hydrolase

description: Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid.


crotonyl-CoA hydratase activity

description: Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.


name: regulation of peptidyl-lysine crotonylation

description: Any process that modulates the frequency, rate or extent of crotonylation of a lysine residue in a protein.


name: negative regulation of peptidyl-lysine crotonylation

description: Any process that stops or reduces the rate of crotonylation of a lysine residue in a protein.


vacuole-isolation membrane contact site

description: An organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome.


description: A protein complex that is involved in the transfer of the second mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. In yeast S. cerevisiae this complex consists of GPI18p and PGA1p.


procentriole

description: A cellular structure that is the site of a developing centriole, which will become a microtubule organizing center. During the canonical pathway of centriole duplication that occurs during the cell division cycle, procentrioles grow at the proximal ends of both mother and daughter centrioles. In the newly divided cells, the original mother and daughter centrioles become mother centrioles while the procentrioles become the new daughter centrioles. Procentrioles can also arise from de novo pathways that occur in multiciliated cells. In ciliated epithelial cells, numerous procentrioles arise form electron dense material referred to as fibrous granules and deuterosomes. The pathway of procentriole formation in multiciliated protists appears to be similar to that in mammalian multiciliated epithelium. In sperm of primitive land plants, multiple procentrioles are formed from a blepharoplast giving rise to multicilated sperm cells.


procentriole replication complex

description: A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates.


bacterial-type flagellum motor

description: A transmembrane complex embedded in the cytoplasmic membrane which is the motor force, or torque, generator of the bacterial-type flagellum. The motor consists of a membrane-anchored rotor complex surrounded by one or more stator complexes in the cytoplasmic membrane. The stator consists of a hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. Examples are the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. The rotor complex consists of a membrane-anchored ring and the motor switch complex, which controls the direction of flagellar rotation.


bacterial-type flagellum stator complex

description: A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species.


name: bacterial-type flagellum secretion apparatus

description: A part of the bacterial-type flagellum that is located at the cytoplasmic side of the MS ring and composed of six membrane proteins (FlhA, FlhB, FliP, FliQ, FliR, and FliO, or orthologs thereof) and three soluble proteins (FliI, FliH, and FliJ, or orthologs thereof) in the cytoplasm. It is responsible for secretion of flagellar type III protein substrates, including the proteins of the flagellar rod, hook, and filament.


centriolar subdistal appendage

description: A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68.


name: mitotic actomyosin contractile ring, proximal layer

description: The region of the mitotic actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located.


name: mitotic actomyosin contractile ring, intermediate layer

description: The region of the mitotic actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer.


name: mitotic actomyosin contractile ring, distal actin filament layer

description: The region of the mitotic actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to.


bacterial-type flagellum rotor complex

description: The rotor complex of the bacterial-type flagellum consists of a membrane-anchored ring and the motor switch complex, which participates in the conversion of proton/Na+ energy into the mechanical work of rotation and controls the direction of flagellar rotation.


description: Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP.


name: mitotic telomere clustering and tethering at nuclear periphery

description: The process in which the telomeres are gathered together to a small number of foci per chromosome (usually one per chromosome or fewer), and moved to and tethered at the nuclear periphery, as part of a mitotic cell cycle.


interphase mitotic telomere clustering

description: The process whereby the mitotic telomeres are gathered together during, or prior to, attachment to the nuclear envelope.


neuron projection cytoplasm

description: All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection.


name: UDP-glucose transmembrane transport into endoplasmic reticulum

description: The directed movement of UDP-glucose from cytosol to endoplasmic reticulum.


name: cytoplasm to vacuole targeting by the NVT pathway

description: A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe.


Sm-like protein family complex

description: A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles.


Lsm2-8 complex

description: A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus.


glucagon processing

description: The formation of mature glucagon by proteolysis of the precursor proglucagon.


T cell meandering migration

description: The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs).


flagella connector

description: A mobile transmembrane junction at the tip of the flagellum of some kinetoplastid species linking the tip of a new growing flagellum to an older flagellum.


flagellum attachment zone

description: A network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species.


bilobe structure

description: A cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone).


tripartite attachment complex

description: A three-part cytoskeletal structure in kinetoplastid species linking mitochondrial DNA organised in a kinetoplast through the mitochondrial membranes to the basal body.


prolactin metabolic process

description: The chemical reactions and pathways involving prolactin, a protein hormone of the anterior pituitary gland that promotes lactation in response to the suckling stimulus of hungry young mammals.


ubiquitin activating enzyme complex

description: A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.


membrane fusion priming complex

description: A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes.


PNGase complex

description: A protein complex responsible for the catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.


response to copper ion starvation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of copper ion.


response to zinc ion starvation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of zinc ion.


name: positive regulation of apoptotic process in bone marrow cell

description: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in the bone marrow.


name: negative regulation of actin cortical patch assembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin cortical patches.


proximal portion of axoneme

description: The portion of the axoneme that is close to the base of the cilium.


distal portion of axoneme

description: The portion of the axoneme that is close to the tip of the cilium.


dUMP kinase activity

description: Catalysis of the reaction: ATP + dUMP = ADP + dUDP.


name: positive regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity

description: Any process that activates or increases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity.


name: regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

description: Any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.


name: positive regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

description: Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.


name: negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.


name: regulation of ecdysone receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of any ecdysone receptor signaling pathway.


name: positive regulation of ecdysone receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of any ecdysone receptor signaling pathway.


name: negative regulation of ecdysone receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of any ecdysone receptor signaling pathway.


name: protein localization to basal ectoplasmic specialization

description: A process in which a protein is transported to, or maintained in, a location within a basal ectoplasmic specialization.


sulfatide binding

description: Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group.


description: Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O.


host cell centrosome

description: A structure in a host cell comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.


host cell peroxisome

description: A small host cell organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.


name: calcium-dependent outer dynein arm binding

description: Binding to an outer dynein arm in the presence of calcium.


calcium-dependent carbohydrate binding

description: Binding to a carbohydrate in the presence of calcium.


name: negative regulation of ERBB4 signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of ERBB4 signaling pathway.


MIH complex

description: A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins.


PAR polarity complex

description: A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC.


name: positive regulation of collagen catabolic process

description: Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.


rRNA pseudouridine synthase activity

description: Catalysis of the reaction: a uridine in rRNA = a pseudouridine in rRNA. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.


name: intraciliary transport particle A binding

description: Binding to an intraciliary transport particle A (IFT A) complex.


name: regulation of cold-induced thermogenesis

description: Any process that modulates the frequency, rate or extent of cold-induced thermogenesis.


name: positive regulation of cold-induced thermogenesis

description: Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.


name: negative regulation of cold-induced thermogenesis

description: Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.


conidium germination

description: The physiological and developmental changes that occur in a conidium or asexual spore following release from dormancy up to the earliest signs of development such as swelling of conidia, adhesion and nuclear decondensation followed by hyphal growth several hours later. In many genera of plant pathogenic fungi (e.g. Magnaporthe, Colletotrichum, Ustilago), swelling of the hyphal tips to form appressorium, metabolic activities including respiration, RNA and protein synthesis and trehalose breakdown and changes in cell wall composition can be detected in conidium germination.


perithecium development

description: The process whose specific outcome is the progression of a perithecium over time, from its formation to the mature structure. Peritheicum is a flask-shaped fruiting body of certain molds and ascomycetous fungi having a pore for the escape of spores. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck.


protoperithecium formation

description: The process of producing fruiting body precursors, called protoperithecia. Protoperitheicium is a spherical structure that is formed in the sexual phase of ascomycetous fungi such as Neurospora crassa and Sordaria macrospora. Protoperithecium is formed by the enveloping of ascogonia cells by sterile hyphae and it develops into perithecium.


name: detection of hot stimulus involved in thermoception

description: The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception.


name: detection of cold stimulus involved in thermoception

description: The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception.


name: intraciliary transport particle B binding

description: Binding to an intraciliary transport particle B (IFT B) complex.


Cdc24p-Far1p-Gbetagamma complex

description: A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit).


name: stress-induced homeostatically regulated protein degradation pathway

description: A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway.


regulation of torso signaling pathway

description: Any process that modulates the frequency, rate or extent of the torso signaling pathway.


name: positive regulation of torso signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the torso signaling pathway.


name: negative regulation of torso signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the torso signaling pathway.


steroid hormone biosynthetic process

description: The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.


adherens junction disassembly

description: The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.


cell-substrate junction disassembly

description: The disaggregation of a cell-substrate junction into its constituent components.


focal adhesion disassembly

description: The disaggregation of a focal adhesion into its constituent components. A focal adhesion is a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also functions as a locus of signal transduction activity.


name: regulation of focal adhesion disassembly

description: Any process that modulates the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components.


name: positive regulation of focal adhesion disassembly

description: Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components.


name: negative regulation of focal adhesion disassembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a focal adhesion into its constituent components.


MBF transcription complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an MBF transcription complex.


name: negative regulation of protein localization to chromatin

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin.


name: positive regulation of protein localization to chromatin

description: Any process that activates or increases the frequency, rate or extent of protein localization to chromatin.


regulation of bile acid secretion

description: Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.


name: positive regulation of bile acid secretion

description: Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.


name: negative regulation of bile acid secretion

description: Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.


name: negative regulation of termination of RNA polymerase II transcription

description: Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription.


tight junction assembly

description: A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.


tight junction organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.


regulation of anther dehiscence

description: Any process involved in the dehiscence of an anther to release the pollen grains contained within it.


name: positive regulation of anther dehiscence

description: Any process that activates or increases the frequency, rate or extent of anther dehiscence.


name: negative regulation of anther dehiscence

description: Any process that stops, prevents, or reduces the frequency, rate or extent of anther dehiscence.


mucociliary clearance

description: The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways.


name: positive regulation of imaginal disc-derived wing size

description: Any process that increases the size of an imaginal disc-derived wing.


cone photoreceptor outer segment

description: The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins.


rod photoreceptor outer segment

description: The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins.


cone photoreceptor disc membrane

description: Stack of disc membranes located inside a cone photoreceptor outer segment, and containing densely packed molecules of opsin photoreceptor proteins that traverse the lipid bilayer. Cone disc membranes arise as evaginations of the ciliary membrane during the development of the cone outer segment and remain contiguous with the ciliary membrane.


rod photoreceptor disc membrane

description: Stack of disc membranes located inside a rod photoreceptor outer segment, and containing densely packed molecules of rhodopsin photoreceptor proteins that traverse the lipid bilayer. It is thought that rod disc membranes arise as evaginations of the ciliary membrane near the base of the outer segment, which then become completely separated from the ciliary membrane, during the development of the rod outer segment.


rod photoreceptor disc lumen

description: The volume enclosed by the membrane of a rod photoreceptor cell disc membrane.


name: methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity

description: Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2.


name: photoreceptor proximal connecting cilium

description: The proximal region of the photoreceptor connecting cilium is similar to the transition zone of unspecialized primary cilia and houses several major transition zone complexes, including NPHP, MKS, and RPGR.


photoreceptor distal connecting cilium

description: The distal region of the photoreceptor connecting cilium is structurally unique to the photoreceptor and is maintained by retina-specific protein, SPATA7, and its interacting partners RPGR and RPGRIP1. It is essential for photoreceptor sensory cilium stability.


endocytosis, site selection

description: The process of selecting and or marking the position where endocytosis will occur.


telodendria

description: Telodendria are projections that originate from the axon pedicle and form gap junctions with other neurons.


cone telodendria

description: Cone telodendria are projections that originate from the cone pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina.


rod telodendria

description: Rod telodendria are projections that originate from the rod pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina.


proacrosomal vesicle fusion

description: Fusion of the membrane of proacrosomal vesicle with the membrane of another proacrosomal vesicle to form the acrosome.


sperm head-tail coupling apparatus

description: A centrosome-based structure consisting of two cylindrical microtubule-based centrioles and associated components which anchors the flagellum to the sperm head.


name: regulation of histidine biosynthetic process

description: Any process that modulates the frequency, rate or extent of histidine biosynthetic process.


name: negative regulation of histidine biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of histidine biosynthetic process.


name: positive regulation of histidine biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of histidine biosynthetic process.


matrilin complex

description: A cartilage extracellular matrix complex that mediates interactions between major components of the extracellular matrix such as collagens and proteoglycans and contributes to their fibrillar network. Exists as an obligate homotrimer.


DNA gyrase complex

description: A bacterial type IIA topoisomerase that is unique in its function of introducing negative supercoils into DNA at the expense of ATP hydrolysis and is also capable of relaxing positive supercoils, an activity shared with topoisomerase IV. Typically, it is composed of two copies each of an A subunit (GyrA) and a B subunit (GyrB).


name: host interaction involved in quorum sensing

description: A quorum sensing process that is modulated by some interaction with a host cell or organism.


subapical part of cell

description: The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina.


basal body patch

description: The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster.


name: maintenance of ciliary planar beating movement pattern

description: Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement.


regulation of blastocyst development

description: Any process that modulates the frequency, rate or extent of blastocyst development.


larynx morphogenesis

description: The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.


larynx development

description: The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.


coenzyme A binding

description: Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.


succinyl-CoA binding

description: Binding to succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component.


acyl-CoA binding

description: Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid.


outer dynein arm docking complex

description: A complex which stabilizes the binding of and correctly positions the outer dynein arm complex along an A-tubule of the flagellar axoneme outer doublet microtubules.


protein localization to motile cilium

description: A process in which a protein is transported to, or maintained in, a location within a motile cilium.


recombinase activator activity

description: Binds to and increases the activity of a recombinase.


name: DNA recombinase auxiliary factor complex

description: A protein complex that binds to a recombinase and incrseases its activity.


prenyl-FMNH2 biosynthetic process

description: The chemical reactions and pathways resulting in prenyl-FMNH2, an essential cofactor for the decarboxylase enzymes UbiD and Fdc1.


prenyl-FMNH2 binding

description: Binding to prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1.


stereocilium coat

description: A glycocalyx on the the endolymphatic surface of a cochlear hair cell that coats the external surface of each stereocilium and maintains a small distance between adjacent stereocilia in the bundle.


name: regulation of post-translational protein targeting to membrane, translocation

description: Any process that modulates the frequency, rate or extent of posttranslational protein translocation through the ER membrane.


name: negative regulation of post-translational protein targeting to membrane, translocation

description: Any process that stops, prevents or reduces the frequency, rate or extent of posttranslational protein translocation through the ER membrane.


name: terminal acetylenic compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom.


sperm glycocalyx

description: The carbohydrate rich layer at the outermost periphery of a sperm cell.


vascular endothelial glycocalyx

description: The carbohydrate-rich layer lining the vascular endothelium connected to the endothelium through a variety of molecules, mainly proteoglycans and glycoproteins. These form a network in which soluble molecules, either plasma- or endothelium-derived, are incorporated.


platelet glycocalyx

description: The carbohydrate rich layer at the outermost periphery of a platelet.


description: Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17.


2-iminobutanoate deaminase activity

description: Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+).


2-iminopropanoate deaminase activity

description: Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate.


name: terminal acetylenic compound metabolic process

description: The chemical reactions and pathways involving a terminal acetylenic compound, involving a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom.


name: terminal acetylenic compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom.


acetylenic compound metabolic process

description: The chemical reactions and pathways involving an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C).


name: acetylenic compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C).


acetylenic compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C).


lateral wall of outer hair cell

description: The lateral wall of an outer hair cell (OHC) is a unique trilaminate composite consisting of the plasma membrane, an underlying cytoskeletal network containing an actin-spectrin cortical lattice, and an adjacent system of circumferential lamellar organelles known as the subsurface cisternae.


fatty acid omega-hydroxylase activity

description: Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


hydrocarbon biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a hydrocarbon, a compound consisting of carbon and hydrogen only.


hydrocarbon metabolic process

description: The chemical reactions and pathways involving a hydrocarbon, a compound consisting of carbon and hydrogen only.


hydrocarbon catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a hydrocarbon, a compound consisting of carbon and hydrogen only.


olefinic compound metabolic process

description: The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C).


olefinic compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C).


olefinic compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C).


peptidyl-threonine acetylation

description: The acetylation of peptidyl-threonine.


peptidyl-threonine O-acetylation

description: The acetylation of peptidyl-threonine to form peptidyl-O-acetyl-L-threonine.


7SK snRNP

description: A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb.


ciliary microtubule quartet

description: A set of four specialized microtubules that originates from the basal bodies and wraps around the ciliary pocket membrane, likely supporting its distinct flask shape.


name: regulation of heterochromatin organization

description: Any process that modulates the frequency, rate, extent or location of heterochromatin organization.


name: negative regulation of heterochromatin organization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization.


name: positive regulation of heterochromatin organization

description: Any process that activates or increases the frequency, rate or extent of heterochromatin organization.


name: regulation of chromosome attachment to the nuclear envelope

description: Any process that modulates the frequency, rate, extent or location of chromosome attachment to the nuclear envelope.


name: negative regulation of chromosome attachment to the nuclear envelope

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chromosome attachment to the nuclear envelope.


name: positive regulation of chromosome attachment to the nuclear envelope

description: Any process that activates or increases the frequency, rate or extent of the chromosome attachment to the nuclear envelope.


pellicular membrane

description: The portion of the plasma membrane surrounding the pellicle, a structure enclosing some parasite cells such as certain apicomplexa and Euglenozoa. These membranes are associated with an infrastructure of microtubules, microfilaments, and other organelles.


paraflagellar rod assembly

description: The aggregation, arrangement and bonding together of a set of components to form a paraflagellar rod, a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme.


ciliary centrin arm

description: A rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules.


name: regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts

description: Any process that modulates the rate, frequency, or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein.


name: negative regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts

description: Any process that stops, prevents or reduces the frequency, rate or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein.


name: positive regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts

description: Any process that activates or increases the frequency, rate or extent of degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein.


ciliary centrin arm assembly

description: The aggregation, arrangement and bonding together of a set of macromolecules to form a ciliary centrin arm, a rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules.


virus coreceptor activity

description: Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity.


cerebral blood circulation

description: The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products.


name: regulation of cerebral blood circulation

description: Any process that modulates the frequency, rate or extent of cerebral blood circulation.


name: positive regulation of cerebral blood circulation

description: Any process that activates or increases the frequency, rate or extent of cerebral blood circulation.


name: negative regulation of cerebral blood circulation

description: Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation.


Z granule

description: A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells that are distinct from, but colocalize with or are adjacent to, P granules and mutator foci and are associated with RNA metabolism. Z granules have been observed in C. elegans.


ciliary pro-basal body

description: The cilary pro-basal body is an immature, partially assembled form of a ciliary basal body found next to the basal body of a cilium. Pro-basal bodies are not capable of nucleating a cilium. As the cell progresses through the cell cycle, continuing assembly will convert the pro-basal body into a mature basal body that is capable of nucleating a cilium.


autolysosome membrane

description: A lipid bilayer that surrounds an autolysosome, a single-membrane-bounded vesicle in which endogenous cellular material is degraded.


autolysosome lumen

description: The volume that is enclosed within the autolysosome single-membrane.


protein serine/threonine kinase binding

description: Binding to a protein serine/threonine kinase.


tryptophan binding

description: Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid.


tyrosine sensor activity

description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of tyrosine.


tryptophan sensor activity

description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of tryptophan.


name: stalled replication fork localization to nuclear periphery

description: A cellular localization process where a DNA replication fork that has stalled is signaled to relocate and anchor to the nuclear periphery for the time necessary to complete recombination-dependent replication.


name: negative regulation of mitotic recombination-dependent replication fork processing

description: Any process that inhibits or decreases the rate of mitotic recombination-dependent replication fork processing. Suppression of recombination at replication forks is necessary to prevent template switching.


name: positive regulation of mitotic recombination-dependent replication fork processing

description: Any process that activates or increases the frequency, rate or extent of mitotic recombination-dependent replication fork processing. Regulation of mitotic recombination prevents recombination between inappropriate homologous sequences. Proteins involved in homologous recombination are required for replication restart.


dynein axonemal particle

description: An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm.


peptide serotonyltransferase activity

description: Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+).


histone serotonyltransferase activity

description: Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+).


peptide dopaminyltransferase activity

description: Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+).


histone dopaminyltransferase activity

description: Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4(+).


description: Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+).


peptide histaminyltransferase activity

description: Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein].


name: peptide lactyltransferase (CoA-dependent) activity

description: Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[protein].


name: histone lactyltransferase (CoA-dependent) activity

description: Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[histone].


background adaptation

description: Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity.


visually-mediated background adaptation

description: Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by melanopsin-expressing eye cells.


description: Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by light sensitive cells in the integument.


regulation of pigmentation

description: Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism.


name: cellular response to actin cytoskeletal stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of perturbations or damage to the actin cytoskeleton.


Hechtian strand

description: An extended membranous thread which firmly connects the plasma membrane to the cell wall during plasmolysis such that the plasma membrane does not separate from the cell wall completely.


axonemal outer doublet assembly

description: The aggregation, arrangement and bonding together of a set of components to form an axonemal outer doublet, a part of an axoneme consisting of a doublet microtubule.


cilium attachment to cell body

description: A process that is carried out at the cellular level which results in the lateral attachment of the cilium to the cell body via the flagellar attachment zone in some trypanosomatid species.


amastigogenesis

description: The morphological, biochemical and genetic changes that induce the differentiation of metacyclic parasites into amastigotes in some of the Trypanosomatidae species such as Leishmania parasites and Trypanosoma cruzi. This process occurs inside the cells of the mammalian hosts, particularly in macrophages and other phagocytic cells for Leishmania parasites.


ciliary pro-basal body maturation

description: A process that is carried out at the cellular level which results in the conversion of an immature and partially assembled ciliary pro-basal body into a mature basal body that is capable of nucleating a cilium.


ciliary basal body segregation

description: The process in which the duplicated basal bodies migrate in pairs to the mitotic poles of the nucleus and results in equal distribution in the daughter cells. Ciliary basal body segregation ensures inheritance of the duplicated mitochondrial DNA to the two daughter cells in the Trypanosoma parasites.


name: regulation of oocyte karyosome formation

description: Any process that modulates the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.


name: negative regulation of oocyte karyosome formation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.


name: positive regulation of oocyte karyosome formation

description: Any process that activates or increases the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.


sperm flagellum assembly

description: The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium).


sperm mitochondrial sheath assembly

description: The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.


olfactory sociosexual communication

description: The use of external chemical cues called pheromones to send social and sexual information between members of the same species, leading to specific behavioral responses. Pheromones may be detected by two olfactory sensory circuits, the main olfactory pathway and the vomeronasal system.


name: long-chain fatty acid omega-1 hydroxylase activity

description: Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


lateral pseudopodium retraction

description: The myosin-based contraction and retraction of a lateral pseudopodium.


name: nuclear envelope adjacent to nuclear pore complex

description: The region of the nuclear envelope situated in close proximity to a nuclear pore complex.


name: lipid modification by small protein conjugation

description: A lipid modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target lipid.


lipid ubiquitination

description: The process in which one or more ubiquitin groups are added to a lipid.


procyclogenesis

description: The morphological, biochemical and genetic changes that induce the differentiation of bloodstream form trypomastigotes into procyclic trypomastigotes in some of the Trypanosomatidae species such as Trypanosoma brucei. This process occurs inside the midgut of the tsetse fly vectors in T. brucei.


NuRD complex binding

description: Binding to a NuRD complex.


appressorium-mediated entry into host

description: Penetration by a symbiont into a host organism via an appressorium. The host is defined as the larger of the organisms involved in a symbiotic interaction.


telopode

description: A telopode is a plasma membrane bounded cell projection that is present on a telocyte and is tens to hundreds of microns long. Telopodes form a labyrinthine system communicating through gap junctions.


name: ATP-dependent DNA (cytosine-5-)-methyltransferase activity

description: Catalytic activity that acts to transfer a methyl group to a DNA molecule, driven by ATP hydrolysis.


name: protein localization to centriolar satellite

description: A process in which a protein is transported to, or maintained in, a location within a centriolar satellite.


rixosome complex

description: A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans.


endothelial tube formation

description: The developmental process pertaining to the initial formation of an endothelial tube.


name: host-mediated regulation of oral microbiota composition

description: The biological process involved in maintaining the steady-state number of cells within a population of free-living cells, such as the bacteria, in the mouth.


radial spoke 1

description: The radial spoke of each group of radial spokes, whether grouped as triplets or doublets, that is most proximal to the base of the cilium. Radial spoke 1 (RS1), similarly to radial spoke 2, is comprised of four domains: 1) a very short base anchored to the A microtubule, 2) an elongaged stalk, 3) a bifurcated neck, and 4) an orthogonal head. The base of RS1 is connected to the tail of the inner dynein arm a/d.


radial spoke 2

description: The radial spoke of each group of radial spokes, whether grouped as triplets or doublets, that is immediately distal to radial spoke 1 (RS1). Radial spoke 2 (RS2), similarly to RS1, is comprised of four domains: 1) a very short base anchored to the A microtubule, 2) an elongaged stalk, 3) a bifurcated neck, and 4) an orthogonal head. The base of RS2 is connected to the tail of the inner dynein arm c.


radial spoke 3

description: Radial spoke 3 (RS3), when present, is the most distal of each group of radial spokes, whether grouped as triplets or doublets. RS3 has significantly different morphology and protein composition than RS1 and RS2 and also extends at a slant from the microtubule doublet, rather than perpendicularly like RS1 and RS2. In some organisms (e.g. Chlamydomonas and Sarcophaga bullata), RS3 is represented only as a stump attached to the A-microtubule lacking the rest of the stalk structure and entirely lacking the head structure.


radial spoke head 1

description: The portion of the radial spoke 1 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme.


radial spoke head 2

description: The portion of the radial spoke 2 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme.


radial spoke head 3

description: The portion of the radial spoke 3 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme.


radial spoke base

description: The short portion of the radial spoke that is directly anchored to the A microtubule of an axonemal microtubule doublet.


radial spoke base 1

description: The short portion of the radial spoke 1 (RS1) that is directly anchored to the A microtubule of an axonemal microtubule doublet.


radial spoke base 2

description: The short portion of the radial spoke 2 (RS2) that is directly anchored to the A microtubule of an axonemal microtubule doublet.


radial spoke base 3

description: The short portion of the radial spoke 3 (RS3 )that is directly anchored to the A microtubule of an axonemal microtubule doublet.


radial spoke neck

description: The radial spoke neck is a complex that connects the spoke stalk to the head.


NAE1-UBA3 complex

description: A heterodimeric E1 complex that activates the ubiquitin-like protein NEDD8. In humans the subunits are NAE1 (also known as APPBP1) and UBA3.


F-actin monooxygenase activity

description: Catalysis of the reaction: L-methionyl-[F-actin] + NADPH + O2 + H+ = L-methionyl-(R)-S-oxide-[F-actin] + NADP+ + H2O.


fatty acid omega-1 hydroxylase activity

description: Catalysis of the reaction: an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


name: medium-chain fatty acid omega-1 hydroxylase activity

description: Catalysis of the reaction: an (omega-1)-ethyl medium-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


EXT1-EXT2 complex

description: A heterodimeric complex capable of glycosyltransferase activity required for the elongation of heparan sulfate chains. In humans, the complex consists of EXT1 and EXT2. In Drosophila, the complex consists of ttv and sotv.


name: histone H3K79 monomethyltransferase activity

description: Catalysis of the reaction: L-lysyl79-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl79-[histone H3] + S-adenosyl-L-homocysteine.


name: histone H3K79 dimethyltransferase activity

description: Catalysis of the reaction: L-lysyl79-[histone H3] + 2 S-adenosyl-L-methionine = 2H+ + N6,N6-methyl-L-lysyl79-[histone H3] + 2 S-adenosyl-L-homocysteine.


tRNA-guanine transglycosylase complex

description: A protein complex that catalyzes the base-exchange of a guanine residue with queuine at the wobble position of the anticodon of tRNAs. The eukaryotic tRNA-guanine transglycosylase exists as a heterodimer of a catalytic subunit (QTRT1 in humans) and an accessory subunit (QTRT2 in humans), whereas the bacterial enzyme is homodimeric.


GDP-mannose pyrophosphorylase complex

description: A protein complex capable of catalyzing the reaction of GTP and mannose-1-phosphate to form GDP-mannose. The complex is a homodimer in most bacteria and a heterodimer in most eukaryotes. In humans, it is composed of a catalytic beta subunit (GMPPB) and a regulatory alpha subunit (GMPPA).


name: hydroxypyruvate reductase (NADPH) activity

description: Catalysis of the reaction: (R)-glycerate + NADP+ = 3-hydroxypyruvate + NADPH + H+.


mitochondrial [4Fe-4S] assembly complex

description: A protein complex capable of condensing two 2Fe-2S clusters into one 4Fe-4S center in mitochondria. In S. cerevisiae, it consists of Isa1 and Isa2. In humans it consists of ISCA1 and ISCA2. Additional proteins may be present.


methyl farnesoate epoxidase activity

description: Catalysis of the reaction: methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase].


farnesoate epoxidase activity

description: Catalysis of the reaction: (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase].


description: A protein complex capable of catalysing the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the histidine residue of translation elongation factor 2 (EF2), which is the first step in the biosynthesis of diphthamide. The complex is a Dph2 homodimer in archaea and a Dph1-Dph2 heterodimer in eukaryotes.


KICSTOR complex

description: A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2.


name: L-aspartate import across plasma membrane

description: The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol.


name: D-aspartate transmembrane transporter activity

description: Enables the transfer of D-aspartate from one side of a membrane to the other.


meiotic nuclear division

description: One of the two nuclear divisions that occur as part of the meiotic cell cycle.


mitotic nuclear division

description: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.


name: regulation of cytoplasmic translational fidelity

description: Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code.


DNA methyltransferase complex

description: A protein complex that possesses DNA methyltransferase activity.


name: mitochondrial ADP transmembrane transport

description: The process in which ADP is transported across a mitochondrial membrane, into or out of the mitochondrion.


cnida

description: A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria.


tRNA adenosine deamination to inosine

description: The removal of an amine group from an adenosine to produce inosine within a tRNA molecule.


name: plus-end-directed endosome transport along mitotic spindle midzone microtubule

description: The directed movement of an endosome towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an endosome to a microtubule, and ends when the endosome reaches its final destination.


name: contractile vacuole tethering involved in discharge

description: The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.


name: contractile vacuole dissociation from plasma membrane

description: The dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network.


contractile vacuole localization

description: The directed movement of the contractile vacuole to a specific location.


name: pore formation during contractile vacuole discharge

description: The formation of a transient pore in the plasma membrane and the attached contractile vacuolar membrane, to release water from the cell. This process does not involve fusion of the two membranes.


exocytic process

description: The cellular processes that contribute to exocytosis.


modification-dependent protein binding

description: Binding to a protein upon post-translation modification of the target protein.


description: Binding to a protein upon phosphorylation of the target protein.


glycosylation-dependent protein binding

description: Binding to a protein upon glycosylation of the target protein.


acetylation-dependent protein binding

description: Binding to a protein upon acetylation of the target protein.


methylation-dependent protein binding

description: Binding to a protein upon methylation of the target protein.


ubiquitin-like protein reader activity

description: A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.


name: ubiquitin-modified protein reader activity

description: A molecular adaptor recognizes and binds a target protein containing a ubiquitination modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.


SUMO-modified protein reader activity

description: A molecular adaptor that recognizes and binds a target protein containing a SUMO modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.


name: cell-cell adhesion in response to extracellular stimulus

description: The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus.


name: mitochondrial polycistronic RNA processing

description: The conversion of polycistronic RNA transcribed from a mitochondrial genome into mono- or bi-cistronic RNAs.


name: cellular detoxification of methylglyoxal

description: Any process carried out at the cellular level that reduces or removes the toxicity of methylglyoxal. These may include chemical modification or transport of methylglyoxal away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


lipid droplet formation

description: A process that results in the assembly, arrangement of constituent parts of a lipid droplet.


name: lipid droplet localization to prospore membrane leading edge

description: Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge.


name: manganese ion export across plasma membrane

description: The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region.


name: regulation of endocardial cushion to mesenchymal transition

description: Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition.


name: negative regulation of endocardial cushion to mesenchymal transition

description: Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition.


name: positive regulation of endocardial cushion to mesenchymal transition

description: Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition.


name: cellular response to oxidised low-density lipoprotein particle stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus.


mitochondrial gene expression

description: The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.


name: organelle localization by membrane tethering

description: The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other.


vacuole-mitochondria membrane tethering

description: The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.


neuron projection arborization

description: The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.


dendrite arborization

description: The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches.


axon arborization

description: The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches.


peptide crotonyltransferase activity

description: Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide.


peptide butyryltransferase activity

description: Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide.


peptidyl-lysine crotonylation

description: The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid.


peptidyl-lysine butyrylation

description: The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid.


histone crotonyltransferase activity

description: Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone.


histone butyryltransferase activity

description: Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone.


hydrogen peroxide channel activity

description: Enables the energy-independent facilitated diffusion of hydrogen peroxide through a transmembrane aqueous pore or channel.