name: isopropanol dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + propan-2-ol = acetone + H+ + NADPH.


category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: isovitexin + UDP-D-glucose = H+ + isovitexin 2''-O-beta-D-glucoside + UDP.


itaconyl-CoA hydratase activity

description: Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O.


juglone 3-hydroxylase activity

description: Catalysis of the reaction: 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H+.


2-dehydropantoate aldolase activity

description: Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde.


ketotetrose-phosphate aldolase activity

description: Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate.


kievitone hydratase activity

description: Catalysis of the reaction: kievitone hydrate = H2O + H+ + kievitone.


kynurenine 7,8-hydroxylase activity

description: Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor.


L-3-cyanoalanine synthase activity

description: Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine.


L-amino-acid dehydrogenase activity

description: Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH.


L-arabinitol 4-dehydrogenase activity

description: Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + H+ + NADH.


L-arabinonate dehydratase activity

description: Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O.


L-arabinonolactonase activity

description: Catalysis of the reaction: L-arabinono-1,4-lactone + H2O = L-arabinonate + H+.


name: L-arabinose 1-dehydrogenase (NAD+) activity

description: Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH.


L-fuconate dehydratase activity

description: Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O.


L-galactonolactone oxidase activity

description: Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 + H+.


L-glutamate oxidase activity

description: Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2.


L-glycol dehydrogenase activity

description: Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+.


L-lysine-lactamase activity

description: Catalysis of the reaction: L-2-aminohexano-6-lactam + H2O = L-lysine.


L-lysine oxidase activity

description: Catalysis of the reaction: L-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4.


L-pipecolate dehydrogenase activity

description: Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate.


L-pipecolate oxidase activity

description: Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate.


L-rhamnonate dehydratase activity

description: Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O.


L-rhamnono-1,4-lactonase activity

description: Catalysis of the reaction: L-rhamnono-1,4-lactone + H2O = L-rhamnonate + H+.


L-rhamnose 1-dehydrogenase activity

description: Catalysis of the reaction: L-rhamnofuranose + NAD+ = L-rhamnono-1,4-lactone + H+ + NADH.


L-sorbose oxidase activity

description: Catalysis of the reaction: L-sorbose + O2 = 5-dehydro-D-fructose + H2O2.


L-threonate 3-dehydrogenase activity

description: Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + H+ + NADH.


L-xylose 1-dehydrogenase activity

description: Catalysis of the reaction: L-xylose + NADP+ = H+ + L-xylono-1,4-lactone + NADPH.


L-xylulose reductase (NADPH) activity

description: Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH.


lactaldehyde reductase (NADPH) activity

description: Catalysis of the reaction: NADP+ + propane-1,2-diol = (S)-lactaldehyde + H+ + NADPH.


lactate 2-monooxygenase activity

description: Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O.


lactate aldolase activity

description: Catalysis of the reaction: (S)-lactate = acetaldehyde + formate.


description: Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate.


lactate racemase activity

description: Catalysis of the reaction: (S)-lactate = (R)-lactate.


description: Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate.


laminaribiose phosphorylase activity

description: Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate.


delta7-sterol 5(6)-desaturase activity

description: Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O.


L-leucine 2,3-aminomutase activity

description: Catalysis of the reaction: L-leucine = (3R)-beta-leucine.


description: Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.


L-leucine dehydrogenase activity

description: Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH.


leucine N-acetyltransferase activity

description: Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H+.


description: Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase].


description: Catalysis of the reaction: H+ + leukotriene E(4) + NADPH + O2 = 20-hydroxy-leukotriene E(4) + H2O + NADP+.


levansucrase activity

description: Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1).


name: lignostilbene alpha beta-dioxygenase activity

description: Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin.


limonin-D-ring-lactonase activity

description: Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate.


linalool 8-monooxygenase activity

description: Catalysis of the reaction: linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + 2 H+ + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase].


linamarin synthase activity

description: Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin.


linoleate isomerase activity

description: Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate.


lombricine kinase activity

description: Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine.


description: Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH.


description: Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons.


description: Catalysis of the reaction: a long-chain fatty aldehyde + CoA + NADP+ = a long-chain fatty acyl-CoA + NADPH.


description: Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP.


lysine-pyruvate 6-transaminase activity

description: Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine.


L-lysine 2,3-aminomutase activity

description: Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate.


lysine 2-monooxygenase activity

description: Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O.


lysine carbamoyltransferase activity

description: Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H+ + phosphate.


lysine dehydrogenase activity

description: Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH.


lysolecithin acylmutase activity

description: Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine.


description: Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys).


macrolide 2'-kinase activity

description: Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H+ + oleandomycin 2'-O-phosphate.


malate-CoA ligase activity

description: Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA.


maleate hydratase activity

description: Catalysis of the reaction: (R)-malate = H2O + maleate.


maleate isomerase activity

description: Catalysis of the reaction: maleate = fumarate.


maleylpyruvate isomerase activity

description: Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate.


malonate CoA-transferase activity

description: Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA.


name: acetylenecarboxylate hydratase activity, producing 3-oxopropanoate

description: Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O.


malonyl-CoA decarboxylase activity

description: Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2.


description: Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate.


maltose phosphorylase activity

description: Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate.


malyl-CoA lyase activity

description: Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate.


mannitol-1-phosphatase activity

description: Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + 2 H+ + phosphate.


name: mannitol 2-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + H+ + NADPH.


mannitol 2-dehydrogenase activity

description: Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH.


name: mannitol dehydrogenase (cytochrome) activity

description: Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+.


description: Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + 3 H+ + NADPH.


mannose isomerase activity

description: Catalysis of the reaction: D-mannose = D-fructose.


mannuronate reductase activity

description: Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+.


melilotate 3-monooxygenase activity

description: Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H+ + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+.


meso-tartrate dehydrogenase activity

description: Catalysis of the reaction: (2R,3S)-tartrate + NAD+ = dihydroxyfumarate + H+ + NADH.


methanol dehydrogenase (NAD+) activity

description: Catalysis of the reaction: methanol + NAD+ = formaldehyde + H+ + NADH.


description: Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine.


methionine decarboxylase activity

description: Catalysis of the reaction: L-methionine + H+ = 3-methylthiopropanamine + CO2.


methylaspartate ammonia-lyase activity

description: Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH4.


methylaspartate mutase activity

description: Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate.


methylguanidinase activity

description: Catalysis of the reaction: H2O + methylguanidine = methylammonium + urea.


methylglutamate dehydrogenase activity

description: Catalysis of the reaction: N-methyl-L-glutamate + A + H2O = L-glutamate + AH(2) + formaldehyde.


description: Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate.


mimosinase activity

description: Catalysis of the reaction: L-mimosine + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine.


cellodextrin phosphorylase activity

description: Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate.


dextrin dextranase activity

description: Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1).


L-gulonate 3-dehydrogenase activity

description: Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH.


L-gulonolactone oxidase activity

description: Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2.


monomethyl-sulfatase activity

description: Catalysis of the reaction: H2O + monomethyl sulfate = H+ + methanol + sulfate.


description: Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester.


morphine 6-dehydrogenase activity

description: Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+.


mycocerosate synthase activity

description: Catalysis of the reaction: acyl-CoA + 7n H+ + n methylmalonyl-CoA + 2n NADPH = n CO2 + n CoA + n H2O + multi-methyl-branched acyl-CoA + 2n NADP+.


name: inositol 2-dehydrogenase (NAD+) activity

description: Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + H+ + NADH.


inositol oxygenase activity

description: Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O + H+.


myo-inosose-2 dehydratase activity

description: Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O.


myosin-light-chain-phosphatase activity

description: Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate.


N,N-dimethylformamidase activity

description: Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate.


description: Catalysis of the reaction: N-acetyl-beta-alanine + H2O = beta-alanine + acetate.


description: Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + acetate.


description: Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate.


description: Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + NAD+ = N-acetyl-D-glucosaminate + 2 H+ + NADH.


N-acylglucosamine 2-epimerase activity

description: Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine.


N-acylhexosamine oxidase activity

description: Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + O2 = N-acetyl-D-glucosaminate + H2O2 + H+.


description: Catalysis of the reaction: N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + H+ + NADH.


description: Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate.


description: Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O + H+ = benzyl alcohol + CO2 + glycine.


N-carbamoylputrescine amidase activity

description: Catalysis of the reaction: N-carbamoylputrescine + H2O + 2 H+ = CO2 + NH4 + putrescine.


N-carbamoylsarcosine amidase activity

description: Catalysis of the reaction: N-carbamoylsarcosine + H2O + 2 H+ = CO2 + NH4 + sarcosine.


N-feruloylglycine deacylase activity

description: Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine.


N-formylglutamate deformylase activity

description: Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate.


description: Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylammonium.


N-methyl-L-amino-acid oxidase activity

description: Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2.


N-methylalanine dehydrogenase activity

description: Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = H+ + methylammonium + NADPH + pyruvate.


description: Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA.


N6-methyl-lysine oxidase activity

description: Catalysis of the reaction: N(6)-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2.


NADP+ nucleosidase activity

description: Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose-2-phosphate + nicotinamide.


name: NADH:ubiquinone reductase (non-electrogenic) activity

description: Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.


NADPH peroxidase activity

description: Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+.


nicotinate dehydrogenase activity

description: Catalysis of the reaction: H2O + NADP+ + nicotinate = 6-hydroxynicotinate + H+ + NADPH.


description: Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP.


nitrate reductase (cytochrome) activity

description: Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite.


nitroethane oxidase activity

description: Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2.


nitrogenase (flavodoxin) activity

description: Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate.


nocardicin-A epimerase activity

description: Catalysis of the reaction: isonocardicin A = nocardicin A.


description: Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1.


name: nucleoside monophosphate kinase activity

description: Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate.


nucleoside phosphotransferase activity

description: Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate.


nucleoside ribosyltransferase activity

description: Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1.


nucleotide diphosphokinase activity

description: Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate.


o-aminophenol oxidase activity

description: Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O.


o-pyrocatechuate decarboxylase activity

description: Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = catechol + CO2.


oleate hydratase activity

description: Catalysis of the reaction: (R)-10-hydroxystearate = H2O + oleate.


omega-amidase activity

description: Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3.


description: Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + H+ + NADH.


opheline kinase activity

description: Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H+.


ornithine N-benzoyltransferase activity

description: Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H+.


ornithine racemase activity

description: Catalysis of the reaction: L-ornithine = D-ornithine.


name: dihydroorotate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: (S)-dihydroorotate + NADP+ = H+ + NADPH + orotate.


orsellinate decarboxylase activity

description: Catalysis of the reaction: o-orsellinate + H+ = CO2 + orcinol.


orsellinate-depside hydrolase activity

description: Catalysis of the reaction: H2O + orsellinate depside = 2 o-orsellinate + H+.


name: succinyl-CoA:oxalate CoA-transferase

description: Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate.


oxalate oxidase activity

description: Catalysis of the reaction: 2 H+ + O2 + oxalate = 2 CO2 + H2O2.


oxaloacetate tautomerase activity

description: Catalysis of the reaction: oxaloacetate = <stereo>enol</stereo>-oxaloacetate.


name: oxoglutarate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: 2-oxoglutarate + CoA + NADP+ = CO2 + NADPH + succinyl-CoA.


pantetheine kinase activity

description: Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate.


pantoate 4-dehydrogenase activity

description: Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + H+ + NADH.


description: Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H+ = (R)-pantetheine + CO2.


pentanamidase activity

description: Catalysis of the reaction: H2O + pentanamide = NH4 + valerate.


peptidyl-glutaminase activity

description: Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3.


description: Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside.


phenylalanine 2-monooxygenase activity

description: Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O.


phenylalanine decarboxylase activity

description: Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2.


phenylalanine dehydrogenase activity

description: Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH.


description: Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H+.


phenylpyruvate decarboxylase activity

description: Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2.


phenylpyruvate tautomerase activity

description: Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate.


phenylserine aldolase activity

description: Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine.


phloretin hydrolase activity

description: Catalysis of the reaction: H2O + phloretin = H+ + phloretate + phloroglucinol.


phorbol-diester hydrolase activity

description: Catalysis of the reaction: H2O + phorbol 12,13-dibutanoate = butanoate + H+ + phorbol 13-butanoate.


phosphate butyryltransferase activity

description: Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA.


description: Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H+ + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD+.


phosphatidylcholine desaturase activity

description: Catalysis of the reaction: An oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O.


phosphatidylinositol deacylase activity

description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H2O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H+.


phosphoadenylylsulfatase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate.


phosphoamidase activity

description: Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate.


phosphoenolpyruvate mutase activity

description: Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate.


description: Catalysis of the reaction: H2O + phosphoenolpyruvate = phosphate + pyruvate.


phosphoglucokinase activity

description: Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H+.


phosphoglycerate kinase (GTP) activity

description: Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H+.


phosphoglycerate phosphatase activity

description: Catalysis of the reaction: 2-phospho-D-glycerate + H2O = D-glycerate + phosphate.


phosphoketolase activity

description: Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O.


description: Catalysis of the reaction: H2O + phosphonoacetaldehyde = acetaldehyde + H+ + phosphate.


phosphoribokinase activity

description: Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H+.


[phosphorylase] phosphatase activity

description: Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate.


phytanate-CoA ligase activity

description: Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H+ + phytanoyl-CoA.


pinosylvin synthase activity

description: Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H+ + 3 malonyl-CoA = 4 CO2 + 4 CoA + pinosylvin.


description: Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H+.


fucokinase activity

description: Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+.


octopamine dehydratase activity

description: Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH4.


oxalate-CoA ligase activity

description: Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H+ + oxalyl-CoA.


oxalomalate lyase activity

description: Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate.


oxamate carbamoyltransferase activity

description: Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate.


oximinotransferase activity

description: Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate.


description: Catalysis of the reaction:1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O.


description: Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9.


polyvinyl-alcohol oxidase activity

description: Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2.


prenyl-diphosphatase activity

description: Catalysis of the reaction: dimethylallyl diphosphate + H2O = diphosphate + prenol.


description: Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine.


description: Catalysis of the reaction: AH(2) + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O.


progesterone monooxygenase activity

description: Catalysis of the reaction: AH(2) + O2 + progesterone = A + H2O + testosterone acetate.


propanediol dehydratase activity

description: Catalysis of the reaction: propane-1,2-diol = H2O + propanal.


description: Catalysis of the reaction: NAD+ + propane-1,2-diol 1-phosphate = H+ + hydroxyacetone phosphate + NADH.


propioin synthase activity

description: Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal.


propionate-CoA ligase activity

description: Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.


description: Catalysis of the reaction: prostaglandin A1 = prostaglandin C1.


prostaglandin-E synthase activity

description: Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2).


prostaglandin E2 9-reductase activity

description: Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.


protocatechuate decarboxylase activity

description: Catalysis of the reaction: 3,4-dihydroxybenzoate + H+ = catechol + CO2.


prunasin beta-glucosidase activity

description: Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile.


pseudouridine kinase activity

description: Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H+ + pseudouridine 5'-phosphate.


psychosine sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate.


pteridine oxidase activity

description: Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown.


pterin deaminase activity

description: Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3.


purine imidazole-ring cyclase activity

description: Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O.


description: Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H+ + phosphate.


putrescine oxidase activity

description: Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2.


pyranose oxidase activity

description: Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2.


pyrazolylalanine synthase activity

description: Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O.


pyridoxal 4-dehydrogenase activity

description: Catalysis of the reaction: NAD+ + pyridoxal = 4-pyridoxolactone + H+ + NADH.


description: Catalysis of the reaction: NADP+ + pyridoxine = H+ + NADPH + pyridoxal.


pyridoxine 4-oxidase activity

description: Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2.


pyridoxine 5-dehydrogenase activity

description: Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor.


pyrithiamine deaminase activity

description: Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3.


pyrogallol 1,2-oxygenase activity

description: Catalysis of the reaction: O2 + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H+.


description: Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+.


pyruvate, phosphate dikinase activity

description: Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H+ + phosphoenolpyruvate.


pyruvate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: CoA + NADP+ + pyruvate = acetyl-CoA + CO2 + NADPH.


name: pyruvate oxidase (CoA-acetylating) activity

description: Catalysis of the reaction: CoA + H+ + O2 + pyruvate = acetyl-CoA + CO2 + H2O2.


questin monooxygenase activity

description: Catalysis of the reaction: H+ + NADPH + O2 + questin = demethylsulochrin + NADP+.


raucaffricine beta-glucosidase activity

description: Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine.


description: Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light.


description: Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H+ + luciferyl sulfate.


retinol isomerase activity

description: Catalysis of the reaction: all-trans-retinol = 11-cis-retinol.


description: Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester.


retinyl-palmitate esterase activity

description: Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+.


rhodopsin kinase activity

description: Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin.


ribitol 2-dehydrogenase (NAD+) activity

description: Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH.


name: ribitol-5-phosphate 2-dehydrogenase [(NAD(P)+] activity

description: Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+.


riboflavin phosphotransferase activity

description: Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN.


riboflavinase activity

description: Catalysis of the reaction: H2O + H+ + riboflavin = D-ribitol + lumichrome.


ribose 1-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: H2O + NADP+ + ribofuranose = D-ribonate + 2 H+ + NADPH.


description: Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH4 = 5-phospho-D-ribosylamine + ADP + 2 H+ + phosphate.


ribose isomerase activity

description: Catalysis of the reaction: ribofuranose = D-ribulose.


ribosylnicotinamide kinase activity

description: Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide.


ribosylpyrimidine nucleosidase activity

description: Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine.


rifamycin-B oxidase activity

description: Catalysis of the reaction: 2 H+ + O2 + rifamycin B = H2O2 + rifamycin O.


RNA uridylyltransferase activity

description: Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1).


rosmarinate synthase activity

description: Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate.


description: Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit.


description: Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH.


description: Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+.


description: Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O + H+ = S-inosyl-L-homocysteine + NH4.


description: Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H+.


description: Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + H+ + succinate.


description: Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H+ + salicin + UDP.


scopoletin glucosyltransferase activity

description: Catalysis of the reaction: scopoletin + UDP-D-glucose = H+ + scopolin + UDP.


scyllo-inosamine 4-kinase activity

description: Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H+.


sedoheptulokinase activity

description: Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H+ + sedoheptulose 7-phosphate.


sedoheptulose-bisphosphatase activity

description: Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate.


sepiapterin deaminase activity

description: Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3.


sequoyitol dehydrogenase activity

description: Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADH.


serine-glyoxylate transaminase activity

description: Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine.


serine 2-dehydrogenase activity

description: Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH.


serine-sulfate ammonia-lyase activity

description: Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate.


sinapate 1-glucosyltransferase activity

description: Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose.


sinapine esterase activity

description: Catalysis of the reaction: O-sinapoylcholine + H2O = choline + H+ + sinapate.


sorbitol-6-phosphatase activity

description: Catalysis of the reaction: D-glucitol 6-phosphate + H2O = D-glucitol + phosphate.


name: sorbose 5-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + H+ + NADPH.


sorbose dehydrogenase activity

description: Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2).


spermidine dehydrogenase activity

description: Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor.


name: sphingomyelin phosphodiesterase D activity

description: Catalysis of the reaction: H2O + sphingomyelin = ceramide 1-phosphate + choline + H+.


sphingosine N-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine.


steroid 9-alpha-monooxygenase activity

description: Catalysis of the reaction: AH(2) + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O.


steroid-lactonase activity

description: Catalysis of the reaction: H2O + testololactone = H+ + testolate.


steroid sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.


steryl-beta-glucosidase activity

description: Catalysis of the reaction: cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol.


stipitatonate decarboxylase activity

description: Catalysis of the reaction: H2O + stipitatonate = CO2 + H+ + stipitatate.


stizolobate synthase activity

description: Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde.


stizolobinate synthase activity

description: Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde.


streptomycin 3''-kinase activity

description: Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 3''-phosphate.


aminoglycoside 6-kinase activity

description: Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 6-phosphate.


streptomycin-6-phosphatase activity

description: Catalysis of the reaction: H2O + streptomycin 6-phosphate = phosphate + streptomycin.


indole-3-acetaldehyde oxidase activity

description: Catalysis of the reaction: (indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2 + H+.


lysine 6-dehydrogenase activity

description: Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine.


nitrous-oxide reductase activity

description: Catalysis of the reaction: H2O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide.


strombine dehydrogenase activity

description: Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H2O + NAD+ = glycine + H+ + NADH + pyruvate.


description: Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose.


sucrose-phosphate phosphatase activity

description: Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate.


sugar-phosphatase activity

description: Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.


sugar-terminal-phosphatase activity

description: Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate.


sulfite dehydrogenase activity

description: Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c.


sulfite reductase (ferredoxin) activity

description: Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin.


sulfur dioxygenase activity

description: Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+.


sym-norspermidine synthase activity

description: Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H+.


synephrine dehydratase activity

description: Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium.


name: T2-induced deoxynucleotide kinase activity

description: Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP.


tagatose kinase activity

description: Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H+.


tannase activity

description: Catalysis of the reaction: digallate + H2O = 2 gallate + H+.


tartrate decarboxylase activity

description: Catalysis of the reaction: L-tartrate + H+ = D-glycerate + CO2.


tartrate epimerase activity

description: Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate.


tau-protein kinase activity

description: Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.


description: Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate.


taurine dehydrogenase activity

description: Catalysis of the reaction: A + H2O + taurine = AH(2) + NH4 + sulfoacetaldehyde.


taurocyamine kinase activity

description: Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H+.


tauropine dehydrogenase activity

description: Catalysis of the reaction: H2O + NAD+ + tauropine = H+ + NADH + pyruvate + taurine.


taxifolin 8-monooxygenase activity

description: Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O.


tetrahydroberberine oxidase activity

description: Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2.


description: Catalysis of the reaction: tetrahydroxypteridine = H+ + xanthine-8-carboxylate.


theanine hydrolase activity

description: Catalysis of the reaction: N(5)-ethyl-L-glutamine + H2O = L-glutamate + ethylamine.


thiamine-diphosphate kinase activity

description: Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate.


thiamine pyridinylase activity

description: Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine.


name: thiamine triphosphate phosphatase activity

description: Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate.


thiaminase activity

description: Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+.


thiocyanate isomerase activity

description: Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate.


description: Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA.


description: Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide.


thiosulfate dehydrogenase activity

description: Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c.


TTPase activity

description: Catalysis of the reaction: dTTP + H2O = dTDP + H+ + phosphate.


thymidylate 5'-phosphatase activity

description: Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate.


thymine dioxygenase activity

description: Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2.


tocopherol C-methyltransferase activity

description: Catalysis of the reaction: gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + H+ + S-adenosyl-L-homocysteine. This reaction can also use delta-tocopherol, gamma-tocotrienol and delta-tocotrienol as substrates.


name: trans-2-enoyl-CoA reductase (NADH) activity

description: Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH.


description: Catalysis of the reaction: trans-cinnamate + H+ + NADPH + O2 = 2-coumarate + H2O + NADP+.


trans-epoxysuccinate hydrolase activity

description: Catalysis of the reaction: trans-2,3-epoxysuccinate + H2O = (2R,3S)-tartrate.


description: Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H2O + H+.


trehalose O-mycolyltransferase activity

description: Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose.


triacetate-lactonase activity

description: Catalysis of the reaction: H2O + triacetate lactone = triacetate.


trihydroxystilbene synthase activity

description: Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2.


trimetaphosphatase activity

description: Catalysis of the reaction: H2O + trimetaphosphate = 2 H+ + triphosphate.


trimethylamine-oxide aldolase activity

description: Catalysis of the reaction: H+ + trimethylamine N-oxide = dimethylamine + formaldehyde.


trimethyllysine dioxygenase activity

description: Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate.


triokinase activity

description: Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H+.


name: inorganic triphosphate phosphatase activity

description: Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate.


tropine dehydrogenase activity

description: Catalysis of the reaction: NADP+ + tropine = H+ + NADPH + tropinone.


tropinesterase activity

description: Catalysis of the reaction: atropine + H2O = H+ + tropate + tropine.


tropinone reductase activity

description: Catalysis of the reaction: NADP+ + pseudotropine = H+ + NADPH + tropinone.


tropomyosin kinase activity

description: Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin.


tryptophan 2'-dioxygenase activity

description: Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3.


tryptophan 2-monooxygenase activity

description: Catalysis of the reaction: L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide.


description: Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate.


tryptophan dehydrogenase activity

description: Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+.


description: Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan.


tryptophanamidase activity

description: Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH4.


tyramine N-feruloyltransferase activity

description: Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine.


tyrosine-arginine ligase activity

description: Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H+.


L-tyrosine 2,3-aminomutase activity

description: Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate.


name: [tyrosine 3-monooxygenase] kinase activity

description: Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase].


tyrosine N-monooxygenase activity

description: Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O.


tyrosine phenol-lyase activity

description: Catalysis of the reaction: L-tyrosine + H2O = NH4 + phenol + pyruvate.


UDP-arabinose 4-epimerase activity

description: Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose.


description: Catalysis of the reaction: H+ + UDP-alpha-D-galacturonate = CO2 + UDP-L-arabinose.


UDP-glucosamine 4-epimerase activity

description: Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine.


UDP-glucose 4,6-dehydratase activity

description: Catalysis of the reaction: UDP-D-glucose = H2O + UDP-4-dehydro-6-deoxy-D-glucose.


UDP-glucuronate 4-epimerase activity

description: Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate.


UDP-glucuronate 5'-epimerase activity

description: Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate.


undecaprenyl-diphosphatase activity

description: Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate.


description: Catalysis of the reaction: H+ + uracil 5-carboxylate = CO2 + uracil.


uracil dehydrogenase activity

description: Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor.


description: Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H+ + urate.


ureidoglycolate lyase activity

description: Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea.


ureidosuccinase activity

description: Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O + 2 H+ = L-aspartate + CO2 + NH4.


urethanase activity

description: Catalysis of the reaction: H2O + H+ + urethane = CO2 + ethanol + NH4.


uronate dehydrogenase activity

description: Catalysis of the reaction: D-galacturonate + H2O + NAD+ = galactarate + 2 H+ + NADH.


uronolactonase activity

description: Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate.


valine decarboxylase activity

description: Catalysis of the reaction: L-valine + H+ = 2-methylpropanamine + CO2.


valine dehydrogenase (NADP+) activity

description: Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH.


vicianin beta-glucosidase activity

description: Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose.


description: Catalysis of the reaction: vinylacetyl-CoA = (2E)-butenoyl-CoA.


viomycin kinase activity

description: Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin.


description: Catalysis of the reaction: UDP-D-glucose + vitexin = H+ + UDP + vitexin 2''-O-beta-D-glucoside.


vomifoliol 4'-dehydrogenase activity

description: Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD+ = (6S)-6-hydroxy-3-oxo-alpha-ionone + H+ + NADH.


description: Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light.


wax-ester hydrolase activity

description: Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate.


xanthommatin reductase activity

description: Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD+ = H+ + NADH + xanthommatin.


xylitol kinase activity

description: Catalysis of the reaction: ATP + xylitol = ADP + 2 H+ + xylitol 5-phosphate.


xylonate dehydratase activity

description: Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O.


xylono-1,4-lactonase activity

description: Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate.


description: Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H+ + UDP.


description: Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H+ + UDP.


description: Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate.


description: Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate.


[pyruvate kinase]-phosphatase activity

description: Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate.


description: Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H+ + UDP.


3-oxolaurate decarboxylase activity

description: Catalysis of the reaction: 3-oxolaurate + H+ = 2-undecanone + CO2.


description: Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP.


description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine.


formimidoylaspartate deiminase activity

description: Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3.


formimidoylglutamase activity

description: Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide.


formimidoylglutamate deiminase activity

description: Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3.


glutamin-(asparagin-)ase activity

description: Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate.


hydroxylamine reductase activity

description: Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor.


hydroxymandelonitrile lyase activity

description: Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate.


maltose synthase activity

description: Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate.


nitrite reductase (NO-forming) activity

description: Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+.


strictosidine beta-glucosidase activity

description: Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone.


thiamine oxidase activity

description: Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2.


name: 3'-phosphoadenosine 5'-phosphosulfate metabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.


name: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.


name: calcium-dependent phospholipase C activity

description: Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+.


transforming growth factor beta binding

description: Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.


catecholamine secretion

description: The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


regulation of catecholamine secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.


name: positive regulation of viral transcription

description: Any process that activates or increases the frequency, rate or extent of viral transcription.


amyloid-beta metabolic process

description: The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP).


microfibril binding

description: Binding to a microfibril, any small fibril occurring in biological material.


(-)-endo-fenchol synthase activity

description: Catalysis of the reaction: geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate.


2-ethylmalate synthase activity

description: Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H+.


description: Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2.


2-methylcitrate synthase activity

description: Catalysis of the reaction: H2O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H+.


3-ethylmalate synthase activity

description: Catalysis of the reaction: butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H+.


3-propylmalate synthase activity

description: Catalysis of the reaction: glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H+.


asparagusate reductase activity

description: Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + H+ + NADH.


azobenzene reductase activity

description: Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+.


description: Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H+.


description: Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2).


casbene synthase activity

description: Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate.


citrate (Re)-synthase activity

description: Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group.


name: CoA-disulfide reductase (NADPH) activity

description: Catalysis of the reaction: 2 CoA + NADP+ = CoA-disulfide + NADPH + H+.


name: CoA-glutathione reductase (NADPH) activity

description: Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+.


coenzyme F420 hydrogenase activity

description: Catalysis of the reaction: coenzyme F420 + H(2) + H+ = reduced coenzyme F420.


columbamine oxidase activity

description: Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O.


cystine reductase activity

description: Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + H+ + NADH.


decylcitrate synthase activity

description: Catalysis of the reaction: H2O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H+.


decylhomocitrate synthase activity

description: Catalysis of the reaction: 2-oxoglutarate + H2O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H+.


description: Catalysis of the reaction: H2O + phosphoethanolamine = acetaldehyde + NH4 + phosphate.


hydroxylamine reductase (NADH) activity

description: Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+.


L-mimosine synthase activity

description: Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate.


N-acetylneuraminate synthase activity

description: Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate.


nitrate reductase [NAD(P)H] activity

description: Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+.


nitrate reductase (NADPH) activity

description: Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+.


description: Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+.


pentalenene synthase activity

description: Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene.


reticuline oxidase activity

description: Catalysis of the reaction: (S)-reticuline + O2 = (S)-scoulerine + H2O2 + H+.


sabinene-hydrate synthase activity

description: Catalysis of the reaction: geranyl diphosphate + H2O = diphosphate + sabinene hydrate.


trimethylamine dehydrogenase activity

description: Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein.


uracilylalanine synthase activity

description: Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate.


zeatin reductase activity

description: Catalysis of the reaction: dihydrozeatin + NADP+ = H+ + NADPH + zeatin.


arachidonate 15-lipoxygenase activity

description: Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.


(S)-norcoclaurine synthase activity

description: Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O.


description: Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate.


acyl-lysine deacylase activity

description: Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate.


glyceryl-ether monooxygenase activity

description: Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine).


imidazolonepropionase activity

description: Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+.


mandelate 4-monooxygenase activity

description: Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O2 = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H2O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate.


arachidonic acid secretion

description: The controlled release of arachidonic acid from a cell or a tissue.


IMP 5'-nucleotidase activity

description: Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate.


GMP 5'-nucleotidase activity

description: Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate.


name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide.


description: Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule.


description: Catalysis of the reaction: acetyl phosphate + H+ + sulfite = phosphate + sulfoacetaldehyde.


description: Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid.


1,4-lactonase activity

description: Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid.


sulcatone reductase activity

description: Catalysis of the reaction: NAD+ + sulcatol = H+ + NADH + sulcatone.


name: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate.


name: GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine

description: The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein.


name: GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine

description: The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein.


name: peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine

description: The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine.


name: peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine

description: The modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide.


alkylthioltransferase activity

description: Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor).


name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated

description: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated.


name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H.


description: Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate.


hyaluronan synthase activity

description: Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP.


description: Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H+ + UDP.


name: trehalose 6-phosphate phosphorylase activity

description: Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate.


description: Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H+.


description: Catalysis of the reaction: hydroquinone + UDP-D-glucose = H+ + hydroquinone O-beta-D-glucopyranoside + UDP.


vomilenine glucosyltransferase activity

description: Catalysis of the reaction: UDP-D-glucose + vomilenine = H+ + raucaffricine + UDP.


description: Catalysis of the reaction: indoxyl + UDP-D-glucose = H+ + indican + UDP.


description: Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP.


description: Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.


description: Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.


description: Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP.


description: Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP.


description: Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H+ + UDP.


name: homospermidine synthase (spermidine-specific) activity

description: Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine.


name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity

description: Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H+.


name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity

description: Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate.


holo-citrate lyase synthase activity

description: Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase.


phosphatidylcholine synthase activity

description: Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H+.


alpha-glucan, water dikinase activity

description: Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate.


name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors

description: Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP.


description: Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB.


cutinase activity

description: Catalysis of the reaction: cutin + H2O = cutin monomers.


description: Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5.


description: Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5.


acyloxyacyl hydrolase activity

description: Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid.


description: Catalysis of the reaction: H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol.


glucosylglycerol 3-phosphatase activity

description: Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate.


description: Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate.


description: Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H2O = (R)-3-sulfolactate + phosphate.


5-phytase activity

description: Catalysis of the reaction: 1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate.


3-deoxyoctulosonase activity

description: Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide.


beta-primeverosidase activity

description: Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol.


description: Catalysis of the reaction: N-acetylphenylethylamine + H2O = acetate + phenylethylamine.


mandelamide amidase activity

description: Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH4.


description: Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate.


maleimide hydrolase activity

description: Catalysis of the reaction: H2O + maleimide = H+ + maleamate.


2-aminomuconate deaminase activity

description: Catalysis of the reaction: 2-aminomuconate + H2O + H+ = (Z)-5-oxohex-2-enedioate + NH4.


description: Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone.


icosanoid binding

description: Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids.


icosatetraenoic acid binding

description: Binding to icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule.


arachidonic acid binding

description: Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.


sulfopyruvate decarboxylase activity

description: Catalysis of the reaction: 3-sulfopyruvate + H+ = CO2 + sulfoacetaldehyde.


description: Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H+ = (4-hydroxyphenyl)acetaldehyde + CO2.


feruloyl-CoA hydratase/lyase activity

description: Catalysis of the reaction: (E)-feruloyl-CoA + H2O = acetyl-CoA + vanillin.


description: Catalysis of the reaction: N-cyclohexylformamide + H+ = cyclohexyl isocyanide + H2O.


pinene synthase activity

description: Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate. This reaction can produce both alpha-pinene and beta-pinene.


myrcene synthase activity

description: Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene.


(4S)-limonene synthase activity

description: Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate.


taxadiene synthase activity

description: Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene.


abietadiene synthase activity

description: Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate.


2-hydroxypropyl-CoM lyase activity

description: Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane.


deacetylisoipecoside synthase activity

description: Catalysis of the reaction: deacetylisoipecoside + H2O = dopamine + secologanin.


deacetylipecoside synthase activity

description: Catalysis of the reaction: deacetylipecoside + H2O = dopamine + secologanin.


maltose epimerase activity

description: Catalysis of the reaction: alpha-maltose = beta-maltose.


copalyl diphosphate synthase activity

description: Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate.


aspartate-tRNA(Asn) ligase activity

description: Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP.


glutamate-tRNA(Gln) ligase activity

description: Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP.


trans-feruloyl-CoA synthase activity

description: Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate.


description: Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H+.


aerobactin synthase activity

description: Catalysis of the reaction: ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H+.


name: asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity

description: Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP.


name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

description: Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP.


protein-glutamine glutaminase activity

description: Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3.


glycolaldehyde dehydrogenase activity

description: Catalysis of the reaction: glycolaldehyde + H2O + NAD+ = glycolate + 2 H+ + NADH.


description: Catalysis of the reaction: 4-(phosphooxy)-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.


description: Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH.


name: L-idonate 5-dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+.


description: Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H+ + NADPH.


description: Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH.


description: Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH.


GDP-L-fucose synthase activity

description: Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+.


description: Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+.


vellosimine dehydrogenase activity

description: Catalysis of the reaction: 10-deoxysarpagine + NADP+ = H+ + NADPH + vellosimine.


description: Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+.


D-mannitol oxidase activity

description: Catalysis of the reaction: mannitol + O2 = mannose + H2O2.


xylitol oxidase activity

description: Catalysis of the reaction: xylitol + O2 = xylose + H2O2.


hydrogen dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + H2 = NADPH + H+.


linoleate 11-lipoxygenase activity

description: Catalysis of the reaction: linoleate + O2 = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate.


4-hydroxymandelate synthase activity

description: Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2.


description: Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H+ + O2 = N-acetylanthranilate + CO.


chlorite O2-lyase activity

description: Catalysis of the reaction: chloride + O2 = chlorite.


description: Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal.


leucocyanidin oxygenase activity

description: Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O.


description: Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2.


quinine 3-monooxygenase activity

description: Catalysis of the reaction: H+ + NADPH + O2 + quinine = 3-hydroxyquinine + H2O + NADP+.


name: 4-hydroxyphenylacetaldehyde oxime monooxygenase activity

description: Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H+ + NADPH + O2 = (S)-4-hydroxymandelonitrile + 2 H2O + NADP+.


description: Catalysis of the reaction: (S)-N-methylcoclaurine + H+ + NADPH + O2 = (S)-3'-hydroxy-N-methylcoclaurine + H2O + NADP+.


tabersonine 16-hydroxylase activity

description: Catalysis of the reaction: H+ + NADPH + O2 + tabersonine = 16-hydroxytabersonine + H2O + NADP+.


7-deoxyloganin 7-hydroxylase activity

description: Catalysis of the reaction: 7-deoxyloganin + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganin + oxidized [NADPH-hemoprotein reductase].


vinorine hydroxylase activity

description: Catalysis of the reaction: H+ + NADPH + O2 + vinorine = H2O + NADP+ + vomilenine.


taxane 10-beta-hydroxylase activity

description: Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP+.


taxane 13-alpha-hydroxylase activity

description: Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5alpha,13alpha-diol.


description: Catalysis of the reaction: 2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate.


acyl-CoA 11-(E)-desaturase activity

description: Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11E)-delta11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O.


description: Catalysis of the reaction: AH(2) + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O + H+.


taxadiene 5-alpha-hydroxylase activity

description: Catalysis of the reaction: AH(2) + O2 + taxa-4,11-diene = A + H2O + taxa-4(20),11-dien-5alpha-ol.


superoxide reductase activity

description: Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin.


name: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity

description: Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + H+ + NADPH.


name: mycothiol-dependent formaldehyde dehydrogenase activity

description: Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+.


vanillin dehydrogenase activity

description: Catalysis of the reaction: H2O + NAD+ + vanillin = 2 H+ + NADH + vanillate.


phosphonate dehydrogenase activity

description: Catalysis of the reaction: H2O + NAD+ + phosphonate = 2 H+ + NADH + phosphate.


methylarsonate reductase activity

description: Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid.


arsenate reductase (azurin) activity

description: Catalysis of the reaction: H2O + arsenite + 2 oxidized azurin = 2 H+ + 2 reduced azurin + arsenate.


arsenate reductase (donor) activity

description: Catalysis of the reaction: A + arsenite + H2O = AH(2) + arsenate + 2 H+.


delta14-sterol reductase activity

description: Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol.


delta24-sterol reductase activity

description: Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol.


description: Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + H+ + NADPH.


secologanin synthase activity

description: Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O.


description: Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin.


description: Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin.


description: Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin.


description: Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin.


tryptophan alpha,beta-oxidase activity

description: Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2 + H+.


name: glycine dehydrogenase (cyanide-forming) activity

description: Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2.


berberine reductase activity

description: Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + H+ + 2 NADPH.


vomilenine reductase activity

description: Catalysis of the reaction: 1,2-dihydrovomilenine + NADP+ = H+ + NADPH + vomilenine.


description: Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H+ + NADH = benzene-1,2,4-triol + NAD+.


name: trimethylamine-N-oxide reductase (cytochrome c) activity

description: Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+.


mycothione reductase activity

description: Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione.


name: 2-oxopropyl-CoM reductase (carboxylating) activity

description: Catalysis of the reaction: acetoacetate + coenzyme M + NADP+ = 2-oxopropyl-coenzyme M + CO2 + NADPH.


name: tetrachloroethene reductive dehalogenase activity

description: Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor. The reaction occurs in the reverse direction.


description: Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol.


corydaline synthase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP+.


description: Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.


description: Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA.


description: Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one.


acridone synthase activity

description: Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H+ + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O.


vinorine synthase activity

description: Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine.


lovastatin nonaketide synthase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+.


description: Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate.


description: Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C.


description: Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate.


name: 6-methylsalicylic acid synthase activity

description: Catalysis of the reaction: acetyl-CoA + 3 H+ + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP+.


description: Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA.


name: 10-deacetylbaccatin III 10-O-acetyltransferase activity

description: Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA.


description: Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H+ + UDP.


limonoid glucosyltransferase activity

description: Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP.


description: Binding to 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds.


description: Binding to 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds.


description: Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds.


description: Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O.


name: chondroitin sulfate proteoglycan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


name: dermatan sulfate proteoglycan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.


name: dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

description: The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate.


name: chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

description: The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate.


name: chondroitin sulfate proteoglycan metabolic process

description: The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


name: dermatan sulfate proteoglycan metabolic process

description: The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.


description: Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.


nucleic acid transport

description: The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


RNA transport

description: The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

description: Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.


flavin adenine dinucleotide binding

description: Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.


NADP binding

description: Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.


name: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule.


hydrogen peroxide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.


name: regulation of homocysteine metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.


homocysteine metabolic process

description: The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.


name: positive regulation of homocysteine metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine.


name: negative regulation of homocysteine metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine.


regulation of lymphocyte proliferation

description: Any process that modulates the frequency, rate or extent of lymphocyte proliferation.


name: positive regulation of lymphocyte proliferation

description: Any process that activates or increases the rate or extent of lymphocyte proliferation.


name: negative regulation of lymphocyte proliferation

description: Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.


epithelial cell proliferation

description: The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.


urothelial cell proliferation

description: The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria.


name: regulation of urothelial cell proliferation

description: Any process that modulates the frequency, rate or extent of urothelial cell proliferation.


name: negative regulation of urothelial cell proliferation

description: Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation.


name: positive regulation of urothelial cell proliferation

description: Any process that activates or increases the rate or extent of urothelial cell proliferation.


name: regulation of epithelial cell proliferation

description: Any process that modulates the frequency, rate or extent of epithelial cell proliferation.


name: positive regulation of epithelial cell proliferation

description: Any process that activates or increases the rate or extent of epithelial cell proliferation.


name: negative regulation of epithelial cell proliferation

description: Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.


nuclear androgen receptor binding

description: Binding to a nuclear androgen receptor.


AF-2 domain binding

description: Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation.


AF-1 domain binding

description: Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor.


regulation of mRNA processing

description: Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.


positive regulation of mRNA processing

description: Any process that activates or increases the frequency, rate or extent of mRNA processing.


negative regulation of mRNA processing

description: Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing.


name: negative regulation of defense response to virus

description: Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.


regulation of defense response to virus

description: Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.


name: negative regulation of defense response to virus by host

description: Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: regulation of defense response to virus by host

description: Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.


DNA binding domain binding

description: Binding to a protein's DNA binding domain (DBD).


LBD domain binding

description: Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket.


galactose 3-O-sulfotransferase activity

description: Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc.


benzoylformate decarboxylase activity

description: Catalysis of the reaction: benzoylformate = benzaldehyde + CO2.


trichloroethylene catabolic process

description: The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent.


name: 1,1,2-trichloroethene reductive dehalogenase activity

description: Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene.


proteoglycan sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans.


WW domain binding

description: Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.


CARD domain binding

description: Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.


regulation of protein secretion

description: Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.


name: negative regulation of protein secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.


name: positive regulation of protein secretion

description: Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.


regulation of inflammatory response

description: Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.


name: negative regulation of inflammatory response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.


name: positive regulation of inflammatory response

description: Any process that activates or increases the frequency, rate or extent of the inflammatory response.


name: regulation of peptidyl-tyrosine phosphorylation

description: Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


name: positive regulation of peptidyl-tyrosine phosphorylation

description: Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


name: negative regulation of peptidyl-tyrosine phosphorylation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


RS domain binding

description: Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing.


hydroxycinnamoyltransferase activity

description: Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule.


N-malonyltransferase activity

description: Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule.


O-malonyltransferase activity

description: Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule.


O-hydroxycinnamoyltransferase activity

description: Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule.