exon-exon junction subcomplex mago-y14

description: Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA.


dense core granule maturation

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.


dendritic lamellar body

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions.


dense core granule exocytosis

description: The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.


name: mitotic DNA replication maintenance of fidelity

description: Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication.


mitotic DNA-templated DNA replication

description: A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle.


CKM complex

description: Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8.


PYM-mago-Y14 complex

description: Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans.


Cry-Per complex

description: Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms.


CLOCK-BMAL transcription complex

description: Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms.


5' transitive RNA interference

description: An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA.


3' transitive RNA interference

description: An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA.


ribonucleotide excision repair

description: The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase.


name: single-stranded 3'-5' DNA helicase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'.


name: pyrimidine nucleotide import into mitochondrion

description: The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix.


separase-securin complex

description: A protein complex that includes separase (a protease which cleaves cohesin as part of chromosome separation) and securin, a protease inhibitor. Chromosome separation is inhibited until securin is degraded by the Anaphase Promoting Complex (APC).


tail spike morphogenesis

description: The process in which the nematode tail spike is generated and organized. An example of this process is seen in C. elegans, where the tapered tail spike is formed during embryogenesis by a filamentous process that passes posteriorly through hyp10, the tail ventral hypodermis; the filamentous process is formed by a binucleate cell, the tail-spike cell, that subsequently undergoes programmed cell death.


bone regeneration

description: The regrowth of bone following its loss or destruction.


INA complex

description: A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p.


BIR domain binding

description: Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain.


Ste12p-Dig1p-Dig2p complex

description: A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae.


Tec1p-Ste12p-Dig1p complex

description: A multiprotein complex that is involved in the transcriptional regulation of primarily filamentation genes, but also mating genes, in the yeast S. cerevisiae.


Rvs161p-Rvs167p complex

description: A protein complex that is involved in endocytosis in the yeast S. cerevisiae.


description: A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M.


Cdc50p-Drs2p complex

description: A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome.


description: A protein complex that functions as a phospholipid-translocating P-Type ATPase.


stress response to nickel ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus.


Dom34-Hbs1 complex

description: A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay.


thermospermine oxidase activity

description: Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine.


neuron projection maintenance

description: The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.


name: phosphoenolpyruvate transmembrane import into Golgi lumen

description: The directed movement of phosphoenolpyruvate into the Golgi lumen across the Golgi membrane.


mitotic spindle polar microtubule

description: Any of the mitotic spindle microtubules that come from each pole and overlap at the spindle midzone.


xylan O-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan.


fructose import across plasma membrane

description: The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol.


name: mitochondrial manganese ion transmembrane transport

description: The process in which a manganese ion is transported across a mitochondrial membrane, into or out of the mitochondrion.


mitochondrial transmembrane transport

description: The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.


name: mitochondrial S-adenosyl-L-methionine transmembrane transport

description: The process in which S-adenosyl-L-methionine is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial ATP transmembrane transport

description: The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial thiamine pyrophosphate transmembrane transport

description: The process in which thiamine pyrophosphate is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial tricarboxylic acid transmembrane transport

description: The process in which a tricarboxylic acid is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial phosphate ion transmembrane transport

description: The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial FAD transmembrane transport

description: The process in which FAD is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial NAD transmembrane transport

description: The process in which NAD is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial alpha-ketoglutarate transmembrane transport

description: The process in which alpha-ketoglutarate is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial 2-oxoadipate transmembrane transport

description: The process in which 2-oxoadipate is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial 5'-adenylyl sulfate transmembrane transport

description: The process in which 5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport

description: The process in which 3'-phospho-5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial oxaloacetate transmembrane transport

description: The process in which oxaloacetate is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial isopropylmalate transmembrane transport

description: The process in which 2-isopropylmalate(2-) is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial sulfate transmembrane transport

description: The process in which sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial malonate(1-) transmembrane transport

description: The process in which malonate(1-) is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: mitochondrial coenzyme A transmembrane transport

description: The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion.


syndecan-syntenin-ALIX complex

description: An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery.


extracellular exosome complex

description: A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome.


protein polyufmylation

description: Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain.


HSP90-CDC37 chaperone complex

description: A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins.


name: I(KACh) inward rectifier potassium channel complex

description: An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G protein-coupled receptor signaling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits.


DPS complex

description: A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22.


description: The process in which UDP-N-acetylglucosamine is transported across a membrane.


GDP-mannose transmembrane transport

description: The process in which GDP-mannose is transported across a membrane.


meiotic centromere clustering

description: The process by which centromeres/kinetochores attach to and migrate along microtubules to become localized to clusters at the spindle pole body during a meiotic prometaphase I.


TERT-RMRP complex

description: A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP).


name: potassium ion import across plasma membrane

description: The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.


meiotic spindle astral microtubule

description: Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.


name: mitochondrial L-ornithine transmembrane transport

description: The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: G protein-coupled glucose receptor activity

description: Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


C-terminal protein demethylation

description: The removal of a methyl group from the C-terminal amino acid of a protein.


name: perinuclear endoplasmic reticulum membrane

description: The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus.


description: The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer.


name: regulation of cytoplasmic translational termination

description: Any process that modulates the frequency, rate or extent of cytoplasmic translational termination.


phospholipase D activator activity

description: Binds to and increases the activity of the enzyme phospholipase D.


cardiac Troponin complex

description: A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction.


description: Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+.


divisome complex

description: A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells.


FtsQBL complex

description: A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ.


FtsBL complex

description: A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL.


ATF4-CREB1 transcription factor complex

description: Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.


ATF1-ATF4 transcription factor complex

description: Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway.


name: asparagine transmembrane import into vacuole

description: The directed movement of asparagine into the vacuole across the vacuolar membrane.


protein K69-linked ufmylation

description: A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.


name: nascent polypeptide-associated complex binding

description: Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.


L-altrarate dehydratase activity

description: Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O.


name: mast cell secretagogue receptor activity

description: Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells.


AIP1-IRE1 complex

description: A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).


name: 3' overhang single-stranded DNA endodeoxyribonuclease activity

description: Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks.


description: Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity.


name: 5' overhang single-stranded DNA endodeoxyribonuclease activity

description: Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks.


dark adaptation

description: The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light.


IRE1-TRAF2-ASK1 complex

description: A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K).


GU repeat RNA binding

description: Binding to an RNA molecule containing GU repeats.


membrane scission GTPase motor activity

description: Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis.


mitotic spindle pole body localization

description: A process in which a mitotic spindle pole body is transported to, or maintained in, a specific cellular location.


name: glutamate-cysteine ligase regulator activity

description: Binds to and modulates the activity of glutamate-cysteine ligase.


name: acetolactate synthase regulator activity

description: Binds to and modulates the activity of acetolactate synthase.


name: regulation of cytoplasmic translational initiation in response to stress

description: Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


Sad1-Kms1 LINC complex

description: A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair.


name: Kelch-containing formin regulatory complex

description: A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p.


magnesium ion export from mitochondrion

description: The directed movement of magnesium ions out of mitochondrial matrix into the cytosol by means of some agent such as a transporter or pore.


CHOP-ATF4 complex

description: A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits.


ANPR-A receptor complex

description: A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure.


ESCRT IV complex

description: An ESCRT complex that has AAA-ATPase activity and is involved in ESCRT-mediated intralumenal vesicle formation and the final stages of cytokinesis. The complex catalyzes disassembly of the ESCRT III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1.


CHOP-ATF3 complex

description: A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits.


Herring body

description: The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively.


name: guanyl nucleotide exchange factor inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor.


name: negative regulation of cytoplasmic translational initiation in response to stress

description: Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.


mitochondrial outer membrane fusion

description: The membrane organization process that joins two mitochondrial outer membranes to form a single membrane.


mitochondrial inner membrane fusion

description: The membrane organization process that joins two mitochondrial inner membranes to form a single membrane.


phospholamban complex

description: A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels.


IRE1-RACK1-PP2A complex

description: A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A.


ErbB-4 class receptor binding

description: Binding to the protein-tyrosine kinase receptor ErbB-4/HER4.


name: branching involved in submandibular gland morphogenesis

description: The process in which the branching structure of the submandibular gland is generated and organized.


mutator focus

description: A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules.


protein phosphatase 5 binding

description: Binding to protein phosphatase 5.


proximal dendrite

description: The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma).


reproductive senescence

description: A life cycle stage during which the reproductive capacity and fitness of an organism declines.


response to prolactin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation.


name: response to granulocyte colony-stimulating factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus.


description: Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate.


response to iron ion starvation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.


name: cellular response to granulocyte colony-stimulating factor

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus.


microtubule site clamp

description: The binding activity of a molecule that attaches the spindle microtubules to the kinetochore.


cellular response to prolactin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus.


C/EBP complex

description: A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities.


description: Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate.


description: Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate.


description: Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate.


description: Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate.


sebum secreting cell proliferation

description: The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum.


4 iron, 3 sulfur cluster binding

description: Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria.


t-SNARE clustering

description: The clustering process in which t-SNARES are localized to distinct domains in the cell membrane. t-SNAREs are cell surface proteins which are part of secretory microdomain assemblies.


iNOS-S100A8/A9 complex

description: A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine.


transnitrosylase complex

description: A transferase complex which is capable of transferring nitrogenous groups from one component to another.


sequestering of manganese ion

description: The process of binding or confining manganese ions such that they are separated from other components of a biological system.


calprotectin complex

description: A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways.


S100A8 complex

description: A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4).


S100A9 complex

description: A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility.


name: dihydroorotate dehydrogenase (fumarate) activity

description: Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate.


Nkx-2.5 complex

description: A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes.


AnxA2-p11 complex

description: A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10).


PCSK9-LDLR complex

description: A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.


PCSK9-AnxA2 complex

description: A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and annexin A2 (AnxA2).


name: vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

description: The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles.


name: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with endoplasmic reticulum membrane

description: The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.


name: vesicle fusion with Golgi cis cisterna membrane

description: The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi cis cisterna. This can involve anterograde or retrograde transport vesicles.


name: vesicle fusion with Golgi medial cisterna membrane

description: The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles.


name: medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane

description: The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport.


Golgi cis cisterna membrane

description: The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex.


Golgi medial cisterna membrane

description: The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex.


Golgi trans cisterna membrane

description: The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex.


name: mitochondrial inner membrane assembly complex

description: A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion.


name: response to melanocyte-stimulating hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates.


CSF1-CSF1R complex

description: A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand.


name: DNA double-strand break attachment to nuclear envelope

description: A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs.


protein-lipid-RNA complex

description: A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other.


description: A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other.


description: A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other.


name: endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

description: The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport.


name: Golgi vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

description: The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.


name: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane

description: The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport.


name: Golgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane

description: The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.


name: cis-Golgi-derived vesicle fusion with Golgi medial cisterna membrane

description: The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport.


name: trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane

description: The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport.


USH2 complex

description: A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7.


protein depalmitoleylation

description: The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein.


palmitoleoyltransferase activity

description: Catalysis of the transfer of a palmitoleoyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule.


palmitoleyl hydrolase activity

description: Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate.


nucleolar chromatin organization

description: Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin.


cholangiocyte proliferation

description: The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water.


MAD1 complex

description: A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C).


conditioned place preference

description: The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug.


presynaptic active zone organization

description: A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone.


MutS complex

description: A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations.


beta-catenin-ICAT complex

description: Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex.


HFE-transferrin receptor complex

description: A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.


survivin complex

description: A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC).


description: Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone.


mRNA CDS binding

description: Binding to an mRNA molecule coding sequence (CDS).


axonemal central apparatus

description: Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules.


axonemal central bridge

description: Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules.


axonemal central pair projection

description: Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules.


C1 axonemal microtubule

description: One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections.


C2 axonemal microtubule

description: One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections.


DAPK1-calmodulin complex

description: A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding.


name: cytoplasmic periphery of the nuclear pore complex

description: Cytoplasm situated in close proximity to a nuclear pore complex.


galectin complex

description: A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes.


cord factor receptor activity

description: Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity.


Lsm1-7-Pat1 complex

description: A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway.


tubulin folding cofactor complex

description: A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur.


name: mitotic spindle assembly checkpoint MAD1-MAD2 complex

description: A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex.


VCP-NSFL1C complex

description: A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.


pyrenoid

description: A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation.


titin-telethonin complex

description: A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils.


name: astral microtubule anchoring at mitotic spindle pole body

description: Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end.


name: gamma-tubulin complex localization to mitotic spindle pole body

description: Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body.


name: regulation of vascular associated smooth muscle cell membrane depolarization

description: Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell.


name: response to manganese-induced endoplasmic reticulum stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus.


pseudouridine 5'-phosphatase activity

description: Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate.


granulosa cell proliferation

description: The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge.


microvesicle

description: An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm.


protein sialylation

description: A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein.


EARP complex

description: A quatrefoil tethering complex required for endocytic recycling.


pancreatic trypsinogen secretion

description: The regulated release of trypsinogen from the cells of the exocrine pancreas.


cellular detoxification

description: Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


name: polynucleotide adenylyltransferase activator activity

description: Increases the activity of the enzyme polynucleotide adenylyltransferase.


Schwann cell chemotaxis

description: The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


microtubule end

description: Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end.


equatorial cell cortex

description: The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression.


name: mitotic spindle microtubule depolymerization

description: The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle.


name: ubiquitin-like ligase-substrate adaptor activity

description: The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins.


ubiquitin ligase activator activity

description: Binds to and increases the activity of a ubiquitin ligase.


mitotic sister chromatid biorientation

description: The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step in metaphase plate congression.


name: osmolarity-sensing monoatomic cation channel activity

description: Enables the transmembrane transfer of a monoatomic cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides.


growth cone lamellipodium

description: A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments.


cytoplasmic alanyl-tRNA aminoacylation

description: The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation.


arrestin family protein binding

description: Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.


myofibroblast contraction

description: The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast.


colon smooth muscle contraction

description: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum.


prostaglandin receptor internalization

description: The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle.


gastric mucosal blood circulation

description: The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products.


proximal neuron projection

description: The portion of an axon or dendrite that is close to the neuronal cell body.


name: small intestine smooth muscle contraction

description: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine.


name: clathrin-dependent extracellular exosome endocytosis

description: The clathrin-mediated endocytosis of an extracellular exosome.


substance P secretion

description: The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity.


matrix metallopeptidase secretion

description: The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins.


endothelin production

description: The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions.


response to angiotensin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.


lipoprotein particle

description: A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph.


protein localization to cell periphery

description: A process in which a protein is transported to, or maintained in, the cell periphery.


glycoprotein Ib-IX-V complex

description: A transmembrane signaling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation.


name: cytoplasmic side of dendritic spine plasma membrane

description: The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine.


name: response to immobilization stress combined with electrical stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile.


protein tyrosine kinase binding

description: Binding to protein tyrosine kinase.


periphagosomal region of cytoplasm

description: Cytoplasm situated near, or occurring around, a phagosome.


response to dsDNA

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus.


name: response to water-immersion restraint stress

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile.


cellular response to dsDNA

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus.


name: negative regulation of hh target transcription factor activity

description: Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling.


GLI-SUFU complex

description: A protein repressing GLI's transcription factor activity when SMO signaling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins.


name: thyroid gland epithelial cell proliferation

description: The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population.


name: response to glial cell derived neurotrophic factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus.


dorsal root ganglion development

description: The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.


name: cellular response to glial cell derived neurotrophic factor

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus.


name: substance P secretion, neurotransmission

description: The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter.


basolateral part of cell

description: The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells.


rod bipolar cell terminal bouton

description: A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer.


photoreceptor cell terminal bouton

description: A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light.


pancreas regeneration

description: The regrowth of a destroyed pancreas.


name: mitochondrial tRNA wobble position uridine thiolation

description: The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.


central cylinder

description: A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules.


name: ligand-gated ion channel signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription.


F-bar domain binding

description: Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins.


name: endoplasmic reticulum tubular network membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane.


name: microtubule anchoring at mitotic spindle pole body

description: Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end.


MWP complex

description: A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin.


growth cone filopodium

description: A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone.


name: meiotic centromeric cohesion protection in anaphase I

description: The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation at meiotic anaphase I after cohesin is cleaved by separase along the arm regions.


DNA/DNA annealing activity

description: An activity that facilitates the formation of a complementary double-stranded DNA molecule.


name: vacuole-mitochondrion membrane contact site

description: A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles.


poly(A) RNA polymerase activity

description: Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.


name: L-arginine transmembrane export from vacuole

description: The directed movement of L-arginine out of the vacuole, across the vacuolar membrane.


mating projection actin fusion focus

description: A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location.


name: response to mitotic DNA integrity checkpoint signaling

description: A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling.


name: basic amino acid transmembrane transport

description: The directed movement of basic amino acids from one side of a membrane to the other.


response to leukemia inhibitory factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.


sequence-specific mRNA binding

description: Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.


name: nucleoplasmic periphery of the nuclear pore complex

description: Nucleoplasm situated in close proximity and peripheral to a nuclear pore complex.


deaminase binding

description: Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3).


hepatocyte dedifferentiation

description: The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.


C-rich single-stranded DNA binding

description: Binding to C-rich, single-stranded DNA.


name: cellular response to leukemia inhibitory factor

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.


name: cellular response to carcinoembryonic antigen

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carcinoembryonic antigen stimulus. The carcinoembryonic antigens represent a family of glycoproteins.


slow axonal transport

description: The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a Slow Component a (SCa) and a Slow Component b (SCb) which differ in transport rates and protein composition.


clathrin-uncoating ATPase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP.


response to odorant

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell.


lysosomal matrix

description: A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome.


name: sequence-specific double-stranded DNA binding

description: Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.


name: poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends

description: Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P).


response to endothelin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3).


response to lectin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties.


promoter-specific chromatin binding

description: Binding to a section of chromatin that is associated with gene promoter sequences of DNA.


adaptive thermogenesis

description: The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.


name: ribonucleoside-diphosphate reductase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase.


vacuolar localization

description: Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell.


H-gal-GP complex

description: A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus.


Wnt-Frizzled-LRP5/6 complex

description: A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6.


name: protein transport along microtubule to spindle pole body

description: The directed movement of a protein along a microtubule to the spindle pole body, mediated by motor proteins.


vacuole-ER tethering

description: The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles.


name: methionyl-initiator methionine tRNA binding

description: Binding to methionine-initiator methionine tRNA.


cellular response to lectin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties.


cellular response to endothelin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3).


Pho85-Pho80 CDK-cyclin complex

description: A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin.


Ubp3-Bre5 deubiquitination complex

description: A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p.


nuclear membrane complex Bqt3-Bqt4

description: A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4.


acinar cell proliferation

description: The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus).


name: response to growth hormone-releasing hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins.


response to gastrin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus.


response to chemokine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.


cellular response to chemokine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.


Vma12-Vma22 assembly complex

description: A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p.


name: vascular associated smooth muscle cell proliferation

description: The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.


nucleoplasmic side of nuclear pore

description: The side of the nuclear pore complex (NPC) that faces the nucleoplasm.


cytoplasmic side of nuclear pore

description: The side of the nuclear pore complex (NPC) that faces the cytoplasm.


FNIP-folliculin RagC/D GAP

description: A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains follicular (FLCN) and either follicular interacting protein 1 (FNIP1) or FNIP2.


cellular response to gastrin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus.


CST complex

description: A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection.


cellular detoxification of copper ion

description: Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration.


rRNA acetylation

description: The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


name: rRNA cytidine N-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.


RNA acetylation

description: The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule.


description: Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+.


H4K20me3 modified histone binding

description: Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation.


netrin receptor binding

description: Binding to a netrin receptor.


mitotic sister chromatid arm separation

description: The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis.


mitotic chromosome arm condensation

description: The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells.


name: mitotic chromosome centromere condensation

description: The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis.


name: regulation of protein localization to cell cortex of cell tip

description: Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip.


name: protein localization to cell cortex of cell tip

description: A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip.


ciliary pocket collar

description: A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma.


old cell pole

description: The cell pole distal from the most recent cell division.


new cell pole

description: The cell pole proximal to the most recent cell division.


ribonucleoprotein complex

description: A macromolecular complex that contains both RNA and protein molecules.


dinoflagellate peduncle

description: A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy).


accessory outer segment

description: A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors.


beta-catenin-TCF complex

description: A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors.


Wnt signalosome

description: A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.


response to hypobaric hypoxia

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level).


response to psychosocial stress

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism.


sperm head plasma membrane

description: The plasma membrane that is part of the head section of a sperm cell.


name: structural constituent of ascospore wall

description: The action of a molecule that contributes to the structural integrity of an ascospore wall.


Isp3 layer of spore wall

description: The outermost layers of the spore wall, as described in Schizosaccharomyces pombe.


ooplasm

description: The cytoplasm of an ovum.


name: double-strand break repair involved in meiotic recombination

description: The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination.


name: proteasome-nuclear membrane anchor activity

description: The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome.


hepatic stellate cell proliferation

description: The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver.


PET complex

description: A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs.


short-term synaptic potentiation

description: The process by which synaptic transmission, induced by the arrival of a spike (action potential) at a synapse, acts to increase the amount of neurotransmitter released in response to the arrival of subsequent spikes. This effect is seen when a train of closely space spikes arrives at a synapse with a low initial release probability. It occurs in a timeframe of tens to hundreds of milliseconds.


name: calcium ion regulated lysosome exocytosis

description: The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.


response to amino acid starvation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.


sulfoquinovosidase activity

description: Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose.


name: mRNA N1-methyladenosine dioxygenase activity

description: Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde.


name: mRNA N6-methyladenosine dioxygenase activity

description: Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.


5.8S rRNA binding

description: Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA.


name: microtubule cytoskeleton attachment to nuclear envelope

description: A process in which the microtubule cytoskeleton is attached to the nuclear envelope.


nucleolus-like body

description: A nuclear compartment containing significant amounts of non-nucleolar, spliceosomal components. It is commonly found in germinal vesicle (GV) stage oocytes, and is similar to both nucleoli and sphere organelles.


splicing factor binding

description: Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA.


name: vascular associated smooth muscle cell dedifferentiation

description: The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.


xylan acetylation

description: The addition of one or more acetyl groups to a xylan molecule.


description: The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein.


mitotic spindle kinetochore microtubule

description: Any of the mitotic spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic chromosome segregation.


mitotic metaphase chromosome recapture

description: A mechanism to recapture 'lost' chromosomes (chromosomes which have become detached from the spindle) during metaphase of mitotic chromosome segregation. Chromosomes with unattached kinetochores are migrated along (non polar) spindle microtubules to the mitotic spindle pole body by a combination of microtubule depolymerisation and 'kinetochore sliding' (migration of the chromosome along the microtubule). The chromosome subsequently migrates along the polar spindle microtubule to the metaphase plate.


name: mating type region replication fork barrier binding

description: Binding to the replication fork barrier found in the mating type region of fission yeast.


meiosis I/meiosis II transition

description: The cell cycle process in which a cell progresses from meiosis I to meiosis II.


exit from meiosis

description: Any process involved in the progression from anaphase/telophase of meiosis II to the creation of end products of meiosis, in which ploidy is reduced by half.


ubiquitin ligase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a ubiquitin ligase.


name: metaphase/anaphase transition of meiosis I

description: The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I.


name: metaphase/anaphase transition of meiosis II

description: The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II.


intramanchette transport

description: The movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments.


G-rich single-stranded DNA binding

description: Binding to G-rich, single-stranded DNA.


fibroblast chemotaxis

description: The directed movement of a fibroblast guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


NPHP complex

description: A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways.


eosinophil homeostasis

description: The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.


basophil homeostasis

description: The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.


name: xenobiotic detoxification by transmembrane export across the plasma membrane

description: A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.


name: xenobiotic transport across blood-brain barrier

description: The directed movement of a xenobiotic through the blood-brain barrier.


establishment of blood-retinal barrier

description: Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type.


actin cytoskeleton-regulatory complex

description: A protein complex probably required for the internalization of endosomes during actin-coupled endocytosis. Links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat.


description: Catalysis of the reaction: cytosylglucuronic acid + H+ = cytosylarabinopyranose + CO2.


ATP generation from poly-ADP-D-ribose

description: The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.


name: modulation by host of RNA binding by virus

description: A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA.


name: modulation by host of viral RNA-binding transcription factor activity

description: A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor.


name: trans-activation response element binding

description: Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter.


EMILIN complex

description: Glycoprotein complex of the C1q/TNF superfamily found in the extracellular matrix (ECM) where it is an important component of the elastic fiber system. A homotrimer that will combine to form supramolecular EMILIN structures.


multimerin complex

description: Glycoprotein complex of the C1q/TNF superfamily involved in cell adhesion. A homotrimer that will combine to form supramolecular Multimerin structures.


name: transmembrane actin-associated (TAN) line

description: A linear array of nuclear envelope membrane proteins composed of nesprin-2G and SUN2, which couple the nucleus to moving actin cables, resulting in rearward nuclear transport (away from the leading edge).


actin-dependent nuclear migration

description: The process whereby the centrosome is held at the cell center while the nucleus moves to the cell rear by actin retrograde flow resulting in the position of the centrosome between the nucleus and the leading edge of the cell.


name: protein transport along microtubule to mitotic spindle pole body

description: The directed movement of a protein along a microtubule to the mitotic spindle pole body, mediated by motor proteins.


name: regulation of translational initiation by tRNA modification

description: A process in which translation initiation is regulated by post-translation modifications of a tRNA molecule.


tRNA demethylase activity

description: Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule.


DNA recombinase disassembly

description: The disaggregation of a DNA recombinase complex into its constituent strand exchange proteins (recombinases).


regulation of DNA damage checkpoint

description: Any process that modulates the frequency, rate or extent of a DNA damage checkpoint.


name: negative regulation of DNA damage checkpoint

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint.


name: positive regulation of DNA damage checkpoint

description: Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint.


name: regulation of metanephric S-shaped body morphogenesis

description: Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis.


name: negative regulation of metanephric S-shaped body morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis.


name: regulation of metanephric comma-shaped body morphogenesis

description: Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis.


name: negative regulation of metanephric comma-shaped body morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis.


name: regulation of protein localization to cell surface

description: Any process that modulates the frequency, rate or extent of protein localization to the cell surface.


name: negative regulation of protein localization to cell surface

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface.


name: positive regulation of protein localization to cell surface

description: Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.


name: regulation of adaxial/abaxial pattern formation

description: Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation.


regulation of auxin polar transport

description: Any process that modulates the frequency, rate or extent of auxin polar transport.


name: regulation of arginine biosynthetic process via ornithine

description: Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine.


regulation of endosperm development

description: Any process that modulates the frequency, rate or extent of endosperm development.


name: regulation of determination of dorsal identity

description: Any process that modulates the frequency, rate or extent of determination of dorsal identity.


name: negative regulation of determination of dorsal identity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity.


name: positive regulation of determination of dorsal identity

description: Any process that activates or increases the frequency, rate or extent of determination of dorsal identity.


regulation of male gonad development

description: Any process that modulates the frequency, rate or extent of male gonad development.


name: negative regulation of male gonad development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development.


name: positive regulation of male gonad development

description: Any process that activates or increases the frequency, rate or extent of male gonad development.


name: regulation of jasmonic acid mediated signaling pathway

description: Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway.


regulation of lateral root development

description: Any process that modulates the frequency, rate or extent of lateral root development.


regulation of leaf development

description: Any process that modulates the frequency, rate or extent of leaf development.


regulation of leaf formation

description: Any process that modulates the frequency, rate or extent of leaf formation.


name: regulation of multicellular organismal development

description: Any process that modulates the frequency, rate or extent of multicellular organismal development.


name: regulation of animal organ morphogenesis

description: Any process that modulates the frequency, rate or extent of animal organ morphogenesis.


regulation of photoperiodism, flowering

description: Any process that modulates the frequency, rate or extent of photoperiodism, flowering.


name: regulation of proanthocyanidin biosynthetic process

description: Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process.


name: regulation of response to red or far red light

description: Any process that modulates the frequency, rate or extent of response to red or far red light.


name: regulation of salicylic acid mediated signaling pathway

description: Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway.


regulation of secondary shoot formation

description: Any process that modulates the frequency, rate or extent of secondary shoot formation.


regulation of seed dormancy process

description: Any process that modulates the frequency, rate or extent of seed dormancy process.


regulation of seed maturation

description: Any process that modulates the frequency, rate or extent of seed maturation.


regulation of stem cell division

description: Any process that modulates the frequency, rate or extent of stem cell division.


name: regulation of stem cell population maintenance

description: Any process that modulates the frequency, rate or extent of stem cell population maintenance.


name: regulation of stomatal complex patterning

description: Any process that modulates the frequency, rate or extent of stomatal complex patterning.


name: regulation of stomatal complex development

description: Any process that modulates the frequency, rate or extent of stomatal complex development.


regulation of trichome morphogenesis

description: Any process that modulates the frequency, rate or extent of trichome morphogenesis.


name: regulation of planar cell polarity pathway involved in axis elongation

description: Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation.


name: negative regulation of planar cell polarity pathway involved in axis elongation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation.


name: negative regulation of double-strand break repair via homologous recombination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination.


name: regulation of cardiac cell fate specification

description: Any process that modulates the frequency, rate or extent of cardiac cell fate specification.


name: negative regulation of cardiac cell fate specification

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac cell fate specification.


name: regulation of G1/S transition of mitotic cell cycle

description: Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.


name: regulation of cell-cell adhesion mediated by cadherin

description: Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin.


name: negative regulation of cell-cell adhesion mediated by cadherin

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin.


name: positive regulation of cell-cell adhesion mediated by cadherin

description: Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin.


name: regulation of non-canonical Wnt signaling pathway

description: Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway.


name: negative regulation of non-canonical Wnt signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway.


name: positive regulation of non-canonical Wnt signaling pathway

description: Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway.


name: regulation of ubiquitin-dependent protein catabolic process

description: Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


name: negative regulation of ubiquitin-dependent protein catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


name: positive regulation of ubiquitin-dependent protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


name: regulation of ureter smooth muscle cell differentiation

description: Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation.


name: negative regulation of ureter smooth muscle cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation.


name: positive regulation of ureter smooth muscle cell differentiation

description: Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation.


name: regulation of cortisol biosynthetic process

description: Any process that modulates the frequency, rate or extent of cortisol biosynthetic process.


name: negative regulation of cortisol biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process.


name: positive regulation of cortisol biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process.


regulation of root morphogenesis

description: Any process that modulates the frequency, rate or extent of root morphogenesis.


name: regulation of defense response to insect

description: Any process that modulates the frequency, rate or extent of defense response to insect.


name: regulation of post-embryonic root development

description: Any process that modulates the frequency, rate or extent of post-embryonic root development.


name: regulation of response to water deprivation

description: Any process that modulates the frequency, rate or extent of response to water deprivation.


name: regulation of defense response by callose deposition

description: Any process that modulates the frequency, rate or extent of defense response by callose deposition.


name: regulation of cytokinesis, site selection

description: Any process that modulates the frequency, rate or extent of site selection that occurs as part of cytokinesis.


name: regulation of type B pancreatic cell development

description: Any process that modulates the frequency, rate or extent of pancreatic B cell development.


name: negative regulation of cytokinesis, site selection

description: Any process that stops, prevents, or reduces the frequency, rate or extent of site selection that occurs as part of cytokinesis.


name: positive regulation of cytokinesis, site selection

description: Any process that activates or increases the frequency, rate or extent of site selection that occurs as part of cytokinesis.