name: B0LBX4_9VIRU Putative nuclear shuttle protein (trembl)


cytoplasm

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.


host cell cytoplasm

description: The cytoplasm of a host cell.


viral capsid

description: The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres.


name: B0LBX6_9VIRU Putative movement protein (trembl)


membrane

description: A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.


name: B0LBX8_9VIRU Putative replicase protein (trembl)


nucleotide binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.


DNA binding

description: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).


RNA binding

description: Binding to an RNA molecule or a portion thereof.


RNA helicase activity

description: Unwinding of an RNA helix, driven by ATP hydrolysis.


endonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.


nucleotidyltransferase activity

description: Catalysis of the transfer of a nucleotidyl group to a reactant.


name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters

description: Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.


metal ion binding

description: Binding to a metal ion.


DNA replication

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.


host cell nucleus

description: A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: K4JUL8_ABHV DNA-directed DNA polymerase (trembl)


DNA-directed DNA polymerase activity

description: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.


3'-5'-DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.


DNA-templated DNA replication

description: A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.


base-excision repair, gap-filling

description: Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template.


name: nucleotide-excision repair, DNA gap filling

description: Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.


SOS response

description: An error-prone process for repairing damaged microbial DNA.


viral DNA genome replication

description: The replication of a viral DNA genome.


DNA replication proofreading

description: Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.


name: K4JUM2_ABHV Putative tRNA ligase (trembl)


ligase activity

description: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.


name: K4JUM7_ABHV Uncharacterized protein (trembl)


DNA ligase (ATP) activity

description: Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).


ATP binding

description: Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.


DNA ligation

description: The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.


lagging strand elongation

description: The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.


DNA repair

description: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.


DNA recombination

description: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.


DNA biosynthetic process

description: The biosynthetic process resulting in the formation of DNA.


name: K4JV09_ABHV Putative inhibitor of apoptosis protein (trembl)


name: cysteine-type endopeptidase inhibitor activity involved in apoptotic process

description: Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.


ubiquitin protein ligase activity

description: Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.


name: positive regulation of protein ubiquitination

description: Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.


name: negative regulation of apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.


regulation of cell cycle

description: Any process that modulates the rate or extent of progression through the cell cycle.


name: K4JV15_ABHV Uncharacterized protein (trembl)


name: K4JV20_ABHV Uncharacterized protein (trembl)


name: K4JV33_ABHV ribonucleoside-diphosphate reductase (trembl)


name: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

description: Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


oxidoreductase activity

description: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.


description: The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


cytosol

description: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.


name: K4JV47_ABHV Putative DEAD-box ATP-dependent RNA helicase (trembl)


helicase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.


hydrolase activity

description: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.


name: K4JV51_ABHV Uncharacterized protein (trembl)


name: K4JV75_ABHV Uncharacterized protein (trembl)


name: K4JV80_ABHV Putative inhibitor of apoptosis protein (trembl)


name: K4JVA2_ABHV Eukaryotic translation initiation factor 3 30 kDa subunit (trembl)


name: K4JX26_ABHV Uncharacterized protein (trembl)


name: K4JX31_ABHV Uncharacterized protein (trembl)


name: K4JX33_ABHV Putative DNA packaging terminase (trembl)


chromosome organization

description: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.


name: K4JX37_ABHV Uncharacterized protein (trembl)


name: K4JX93_ABHV PHTF1/2 N-terminal domain-containing protein (trembl)


name: K4JYD8_ABHV Putative eukaryotic translation initiation factor (trembl)


translation initiation factor activity

description: Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.


GDP-dissociation inhibitor activity

description: Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.


name: formation of translation preinitiation complex

description: The joining of the small ribosomal subunit, ternary complex, and mRNA.


name: formation of cytoplasmic translation initiation complex

description: Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.


translation

description: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.


translational initiation

description: The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


name: K4JYE9_ABHV Uncharacterized protein (trembl)


actin filament polymerization

description: Assembly of actin filaments by the addition of actin monomers to a filament.


actin filament

description: A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.


name: K4JYG0_ABHV Putative DNA replication origin-binding helicase (trembl)


DNA replication origin binding

description: Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.


name: K4JYG8_ABHV Uncharacterized protein (trembl)


name: K4JYH2_ABHV Uncharacterized protein (trembl)


name: K4JYI3_ABHV Uncharacterized protein (trembl)


name: K4JYK0_ABHV Putative methyltransferase (trembl)


methyltransferase activity

description: Catalysis of the transfer of a methyl group to an acceptor molecule.


methylation

description: The process in which a methyl group is covalently attached to a molecule.


name: K4JYM5_ABHV Putative guanylate kinase (trembl)


guanylate kinase activity

description: Catalysis of the reaction: ATP + GMP = ADP + GDP.


kinase activity

description: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


GMP metabolic process

description: The chemical reactions and pathways involving GMP, guanosine monophosphate.


GDP metabolic process

description: The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate.


name: K4K8F3_ABHV Uncharacterized protein (trembl)


name: K4K8G2_ABHV Ribonucleoside-diphosphate reductase (trembl)


description: An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.


name: K4K8H0_ABHV Uncharacterized protein (trembl)


name: K4K8L0_ABHV Uncharacterized protein (trembl)


name: K4K8L9_ABHV Putative chloride channel (trembl)


chloride channel activity

description: Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel.


chloride transmembrane transport

description: The process in which chloride is transported across a membrane.


name: K4K8M7_ABHV Uncharacterized protein (trembl)


name: A0A223FUM6_9VIRU Capsid protein (trembl)


structural molecule activity

description: The action of a molecule that contributes to the structural integrity of a complex.


RNA-dependent RNA polymerase activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.


mRNA methyltransferase activity

description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.


RNA-templated transcription

description: The synthesis of an RNA transcript from an RNA template.


DNA-templated transcription

description: The synthesis of an RNA transcript from a DNA template.


RNA processing

description: Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.


viral RNA genome replication

description: The replication of a viral RNA genome.


name: A0A3T1CWE1_9VIRU Putative HD hydrolase (trembl)


name: A0A3T1CWE3_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWE6_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWF2_9VIRU Ser/Thr protein kinase (trembl)


protein kinase activity

description: Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.


name: protein serine/threonine kinase activity

description: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


signal transduction

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.


cyclic nucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.


intracellular signal transduction

description: The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.


name: A0A3T1CWF8_9VIRU Putative glycosyltransferase (trembl)


transferase activity

description: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.


name: A0A3T1CWG1_9VIRU DEDDy 3'-5' exonuclease (trembl)


nucleic acid binding

description: Binding to a nucleic acid.


exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.


3'-5' exonuclease activity

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.


name: nucleobase-containing compound metabolic process

description: Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.


name: A0A3T1CWG5_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWG6_9VIRU Nucleotide sugar dehydrogenase (trembl)


name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.


name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.


NAD binding

description: Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.


polysaccharide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


name: A0A3T1CWH0_9VIRU Putative GIY-YIG endonuclease (trembl)


name: crossover junction DNA endonuclease activity

description: Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).


5'-flap endonuclease activity

description: Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.


name: double-strand break repair via homologous recombination

description: The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.


name: A0A3T1CWH3_9VIRU Uncharacterized protein (trembl)


thymidylate kinase activity

description: Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.


dUDP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate).


dTDP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).


dTTP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.


description: The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside.


protein heterodimerization activity

description: Binding to a nonidentical protein to form a heterodimer.


name: A0A3T1CWL4_9VIRU non-specific serine/threonine protein kinase (trembl)


name: A0A3T1CWM2_9VIRU Zf-PARP domain-containing protein (trembl)


zinc ion binding

description: Binding to a zinc ion (Zn).


name: A0A3T1CWM3_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWN5_9VIRU DNA methyltransferase (trembl)


RNA methyltransferase activity

description: Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.


name: site-specific DNA-methyltransferase (adenine-specific) activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.


name: A0A3T1CWN8_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWN9_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWP0_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWP1_9VIRU Linker histone H1 (trembl)


nucleosome assembly

description: The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.


nucleosome

description: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.


name: A0A3T1CWP5_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWP8_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWP9_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWQ0_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWQ1_9VIRU Globin domain-containing protein (trembl)


heme binding

description: Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.


name: A0A3T1CWQ2_9VIRU Rho termination factor N-terminal domain-containing protein (trembl)


DNA-templated transcription termination

description: The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template.


name: A0A3T1CWQ7_9VIRU PKD domain-containing protein (trembl)


name: A0A3T1CWR5_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWS2_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWT2_9VIRU Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (trembl)


translation elongation factor activity

description: Functions in chain elongation during polypeptide synthesis at the ribosome.


description: Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.


7-methylguanosine mRNA capping

description: The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively.


translational elongation

description: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.


name: A0A3T1CWU0_9VIRU BTB/POZ domain-containing protein (trembl)


ubiquitin protein ligase binding

description: Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.


regulation of proteolysis

description: Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.


name: proteasome-mediated ubiquitin-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


name: A0A3T1CWU4_9VIRU Ser/Thr protein kinase (trembl)


name: A0A3T1CWU9_9VIRU High mobility group protein (trembl)


DNA binding, bending

description: The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


name: regulation of transcription by RNA polymerase II

description: Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.


name: A0A3T1CWV1_9VIRU Amino acid transporter transmembrane domain-containing protein (trembl)


name: A0A3T1CWV2_9VIRU Ser/Thr protein kinase (trembl)


name: A0A3T1CWV4_9VIRU Endonuclease/exonuclease/phosphatase domain-containing protein (trembl)


phospholipase activity

description: Catalysis of the hydrolysis of a glycerophospholipid.


description: Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.


sphingomyelin metabolic process

description: The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.


name: A0A3T1CWV6_9VIRU Major capsid protein (trembl)


name: A0A3T1CWV8_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWW2_9VIRU Putative HNH endonuclease (trembl)


name: A0A3T1CWW9_9VIRU Zf-PARP domain-containing protein (trembl)


name: A0A3T1CWX5_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWY5_9VIRU Putative late transcription factor VLTF-3 (trembl)


regulation of viral transcription

description: Any process that modulates the frequency, rate or extent of the transcription of the viral genome.


name: A0A3T1CWY7_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWY9_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CWZ6_9VIRU BTB/POZ domain-containing protein (trembl)


protein homooligomerization

description: The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.


name: A0A3T1CWZ8_9VIRU G2/mitotic-specific cyclin (trembl)


name: cyclin-dependent protein serine/threonine kinase regulator activity

description: Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.


name: A0A3T1CX07_9VIRU DOD-type homing endonuclease domain-containing protein (trembl)


phosphoprotein phosphatase activity

description: Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.


protein tyrosine phosphatase activity

description: Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


name: A0A3T1CX11_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CX15_9VIRU Putative membrane protein (trembl)


name: A0A3T1CX16_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CX17_9VIRU ribonuclease H (trembl)


RNA-DNA hybrid ribonuclease activity

description: Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.


mismatch repair

description: A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.


RNA metabolic process

description: The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


DNA replication, removal of RNA primer

description: Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.


ribonuclease H2 complex

description: A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p.


name: hydrolase activity, hydrolyzing O-glycosyl compounds

description: Catalysis of the hydrolysis of any O-glycosyl bond.


beta-glucosidase activity

description: Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.


carbohydrate metabolic process

description: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.


carbohydrate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.


name: A0A3T1CX24_9VIRU Serine hydrolase (trembl)


name: A0A3T1CX32_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CX36_9VIRU Putative tRNA-His guanylyltransferase (trembl)


name: A0A3T1CX39_9VIRU Ser/Thr protein kinase (trembl)


name: A0A3T1CX46_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CX48_9VIRU Exonuclease domain-containing protein (trembl)


name: A0A3T1CX51_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CX53_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CX54_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CX57_9VIRU Class 3 lipase (trembl)


lipid metabolic process

description: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.


name: A0A3T1CX58_9VIRU thymidylate synthase (trembl)


dihydrofolate reductase activity

description: Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.


thymidylate synthase activity

description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.


dTMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).


nucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).


name: A0A3T1CX61_9VIRU Protein kinase domain-containing protein (trembl)


structural constituent of chromatin

description: The action of a molecule that contributes to the structural integrity of chromatin.


rRNA transcription

description: The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.


name: A0A3T1CX63_9VIRU ribonucleoside-diphosphate reductase (trembl)


name: A0A3T1CX75_9VIRU BTB/POZ domain-containing protein (trembl)


name: A0A3T1CX87_9VIRU Dihydrofolate reductase (trembl)


tetrahydrofolate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.


name: A0A3T1CX89_9VIRU DNA-3-methyladenine glycosylase (trembl)


catalytic activity

description: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.


description: Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.


alkylated DNA binding

description: Binding to an alkylated residue in DNA.


description: Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site.


base-excision repair

description: In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.


base-excision repair, AP site formation

description: The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.


DNA alkylation repair

description: The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases.


response to stress

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


protein-DNA complex

description: A macromolecular complex containing both protein and DNA molecules.


name: A0A3T1CX97_9VIRU Ribonucleoside-diphosphate reductase (trembl)


name: A0A3T1CXA2_9VIRU FG-GAP repeat-containing protein (trembl)


name: A0A3T1CXA5_9VIRU Deoxycytidylate deaminase (trembl)


name: A0A3T1CXA8_9VIRU Ser/Thr protein kinase (trembl)


regulation of autophagy

description: Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


positive regulation of autophagy

description: Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


response to starvation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.


name: negative regulation of collateral sprouting

description: Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting.


axon extension

description: Long distance growth of a single axon process involved in cellular development.


phagophore assembly site

description: Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.


autophagosome

description: A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.


phagophore assembly site membrane

description: A cellular membrane associated with the phagophore assembly site.


name: A0A3T1CXB5_9VIRU PAN domain-containing protein (trembl)


name: A0A3T1CXB8_9VIRU Nucleoside diphosphate kinase (trembl)


name: A0A3T1CXC4_9VIRU Permuted papain-like amidase YaeF/Yiix C92 family enzyme (trembl)


name: A0A3T1CXC5_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXC9_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXD0_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXD1_9VIRU Proliferating cell nuclear antigen (trembl)


name: DNA polymerase processivity factor activity

description: An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.


leading strand elongation

description: The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork.


regulation of DNA replication

description: Any process that modulates the frequency, rate or extent of DNA replication.


translesion synthesis

description: The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.


name: A0A3T1CXD2_9VIRU dUTP diphosphatase (trembl)


magnesium ion binding

description: Binding to a magnesium (Mg) ion.


dUTP diphosphatase activity

description: Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate.


dUMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate).


dUTP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate.


name: A0A3T1CXD4_9VIRU PAN domain-containing protein (trembl)


name: A0A3T1CXD7_9VIRU PIF1-like helicase (trembl)


DNA helicase activity

description: Unwinding of a DNA helix, driven by ATP hydrolysis.


catalytic activity, acting on DNA

description: Catalytic activity that acts to modify DNA.


telomere maintenance

description: Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.


DNA duplex unwinding

description: The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.


name: A0A3T1CXD8_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXE0_9VIRU GTP binding nuclear protein Ran (trembl)


GTPase activity

description: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.


GTP binding

description: Binding to GTP, guanosine triphosphate.


protein import into nucleus

description: The directed movement of a protein from the cytoplasm to the nucleus.


nucleocytoplasmic transport

description: The directed movement of molecules between the nucleus and the cytoplasm.


host cell plasma membrane

description: The plasma membrane surrounding a host cell.


name: A0A3T1CXE1_9VIRU CCDC81-like prokaryotic HU domain-containing protein (trembl)


name: A0A3T1CXE6_9VIRU WD40 domain-containing protein (trembl)


description: Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.


description: Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.


extrinsic component of membrane

description: The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


name: A0A3T1CXE8_9VIRU Ribonuclease H (trembl)


name: A0A3T1CXE9_9VIRU Putative myristoylated membrane protein (trembl)


name: A0A3T1CXF0_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXF4_9VIRU Rho termination factor N-terminal domain-containing protein (trembl)


name: A0A3T1CXF7_9VIRU Sugar ABC transporter permease (trembl)


name: A0A3T1CXF8_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXG0_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXG4_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXG8_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXH2_9VIRU UBA-like domain-containing protein (trembl)


unfolded protein binding

description: Binding to an unfolded protein.


protein targeting to membrane

description: The process of directing proteins towards a membrane, usually using signals contained within the protein.


nascent polypeptide-associated complex

description: A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.


name: A0A3T1CXH3_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXH4_9VIRU Endonuclease V (trembl)


single-stranded RNA binding

description: Binding to single-stranded RNA.


name: RNA endonuclease activity, producing 5'-phosphomonoesters

description: Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.


deoxyribonuclease V activity

description: Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.


name: A0A3T1CXH6_9VIRU Initiation factor eIF1/SUI (trembl)


ribosomal small subunit binding

description: Binding to a small ribosomal subunit.


name: A0A3T1CXI3_9VIRU Protein phosphatase 2C (trembl)


name: protein serine/threonine phosphatase activity

description: Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.


name: negative regulation of stress-activated MAPK cascade

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


name: positive regulation of canonical NF-kappaB signal transduction

description: Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade.


name: negative regulation of canonical NF-kappaB signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.


name: positive regulation of canonical Wnt signaling pathway

description: Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


name: A0A3T1CXI5_9VIRU Ser/Thr protein kinase (trembl)


name: A0A3T1CXI9_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXJ1_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXJ3_9VIRU Replication factor C subunit 1 (trembl)


DNA clamp loader activity

description: Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis.


ATP hydrolysis activity

description: Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.


DNA clamp unloader activity

description: Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis.


DNA clamp unloading

description: The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates.


DNA replication factor C complex

description: A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.


name: A0A3T1CXJ9_9VIRU Proliferating cell nuclear antigen (trembl)


name: ATP-dependent chromatin remodeler activity

description: An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.


chromatin remodeling

description: A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.


name: A0A3T1CXK2_9VIRU DNA polymerase (trembl)


name: A0A3T1CXK6_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXK7_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXK8_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXL0_9VIRU Fibronectin type III domain-containing protein (trembl)


name: A0A3T1CXL3_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXL5_9VIRU Nudix hydrolase (trembl)


NADH pyrophosphatase activity

description: Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+.


ADP-ribose diphosphatase activity

description: Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.


name: A0A3T1CXL7_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXM5_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXM6_9VIRU Putative DNA primase (trembl)


name: A0A3T1CXN1_9VIRU Mitochondrial chaperone BCS1 (trembl)


cysteine-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


proteolysis

description: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.


name: A0A3T1CXP1_9VIRU PAN domain-containing protein (trembl)


name: A0A3T1CXR3_9VIRU Transcription elongation factor S-II (trembl)


name: A0A3T1CXU1_9VIRU dihydrofolate reductase (trembl)


NADP binding

description: Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.


dihydrofolate metabolic process

description: The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate.


folic acid metabolic process

description: The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.


name: A0A3T1CXU2_9VIRU Uncharacterized protein (trembl)


name: A0A3T1CXV6_9VIRU Zf-MYND domain-containing protain (trembl)


name: YR665_MIMIV Uncharacterized protein R665 (sprot)


name: COLL7_MIMIV Collagen-like protein 7 (sprot)


name: extracellular matrix structural constituent conferring tensile strength

description: A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.


extracellular matrix organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.


extracellular space

description: That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.


virion component

description: Any constituent part of a virion, a complete fully infectious extracellular virus particle.


name: YL673_MIMIV Putative serine/threonine-protein kinase L673 (sprot)


protein serine kinase activity

description: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.


name: YL670_MIMIV Putative serine/threonine-protein kinase L670 (sprot)


name: YR679_MIMIV Putative serine/threonine-protein kinase R679 (sprot)


name: YL678_MIMIV Putative SET domain-containing protein L678 (sprot)


name: YL675_MIMIV Putative ankyrin repeat protein L675 (sprot)


name: regulation of barbed-end actin filament capping

description: Any process that modulates the frequency, rate or extent of barbed-end actin filament capping.


name: UVE1H_MIMIV Putative UV-damage endonuclease (sprot)


nucleotide-excision repair

description: A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).


response to UV

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.


name: YL682_MIMIV Uncharacterized protein L682 (sprot)


name: YR694_MIMIV Uncharacterized protein R694 (sprot)


name: MGMT_MIMIV Probable methylated-DNA--protein-cysteine methyltransferase (sprot)


description: Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.


name: YR692_MIMIV Uncharacterized protein R692 (sprot)


name: YR691_MIMIV Uncharacterized protein R691 (sprot)


name: YL688_MIMIV Uncharacterized protein L688 (sprot)


name: YL690_MIMIV Uncharacterized protein L690 (sprot)


name: UNAP_MIMIV Probable UDP-N-acetylglucosamine pyrophosphorylase (sprot)


description: Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.


description: The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


biosynthetic process

description: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.


name: YL701_MIMIV Uncharacterized protein L701 (sprot)


host cell membrane

description: Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: YR699_MIMIV Uncharacterized protein R699 (sprot)


description: Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.


name: YR695_MIMIV Uncharacterized protein R695 (sprot)


name: YR707_MIMIV Uncharacterized protein R707 (sprot)


glycosyltransferase activity

description: Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).


name: YR706_MIMIV Uncharacterized protein R706 (sprot)


name: YR705_MIMIV Uncharacterized protein R705 (sprot)


name: YL702_MIMIV Uncharacterized protein L702 (sprot)


name: YL720_MIMIV Endonuclease 8-like L720 (sprot)


damaged DNA binding

description: Binding to damaged DNA.


name: DNA-(apurinic or apyrimidinic site) endonuclease activity

description: Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).


name: hydrolase activity, hydrolyzing N-glycosyl compounds

description: Catalysis of the hydrolysis of any N-glycosyl bond.


DNA N-glycosylase activity

description: Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.


name: YL716_MIMIV Putative glutamine amidotransferase-like protein L716 (sprot)


glutamine metabolic process

description: The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.


name: YL725_MIMIV Uncharacterized protein L725 (sprot)


name: YL724_MIMIV Uncharacterized protein L724 (sprot)


name: YR722_MIMIV Uncharacterized protein R722 (sprot)


metallopeptidase activity

description: Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


name: YR721_MIMIV Uncharacterized protein R721 (sprot)


name: CFXQ_MIMIV Putative cfxQ-like protein R730 (sprot)


name: YR727_MIMIV Uncharacterized protein R727 (sprot)


name: YL733_MIMIV Uncharacterized ABC transporter ATP-binding protein/permease L733 (sprot)


name: ATPase-coupled transmembrane transporter activity

description: Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.


transmembrane transport

description: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.


name: ATP-binding cassette (ABC) transporter complex

description: A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.


name: YL742_MIMIV Putative BTB/POZ domain-containing protein L742 (sprot)


name: YR740_MIMIV Uncharacterized protein R740 (sprot)


mitochondrial fission

description: The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


name: Y749_MIMIV Putative homeobox protein R749 (sprot)


name: RNA polymerase II transcription regulatory region sequence-specific DNA binding

description: Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.


name: DNA-binding transcription factor activity

description: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.


animal organ morphogenesis

description: Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


anterior/posterior axis specification

description: The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.


cell differentiation

description: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


name: YR756_MIMIV Uncharacterized protein R756 (sprot)


iron-sulfur cluster binding

description: Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.


4 iron, 4 sulfur cluster binding

description: Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.


tRNA methylation

description: The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.


rRNA base methylation

description: The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.


name: YR753_MIMIV Putative F-box/LRR-repeat protein R753 (sprot)


name: YR848_MIMIV Putative ankyrin repeat protein R848 (sprot)


name: transcription cis-regulatory region binding

description: Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.


name: positive regulation of transcription by RNA polymerase II

description: Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.


name: YR866_MIMIV Uncharacterized protein R866 (sprot)


name: YR260_MIMIV DnaJ-like protein R260 (sprot)


Hsp70 protein binding

description: Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.


protein folding

description: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.


name: YR259_MIMIV Uncharacterized protein R259 (sprot)


tRNA guanylyltransferase activity

description: Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs.


tRNA modification

description: The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.


tRNA 5'-end processing

description: The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA.


thymidine kinase activity

description: Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.


name: deoxyribonucleoside monophosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.


thymidine metabolic process

description: The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.


name: YR853_MIMIV Uncharacterized protein R853 (sprot)


name: YL851_MIMIV Uncharacterized protein L851 (sprot)


aminoacyl-tRNA ligase activity

description: Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.


cysteine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).


name: tRNA aminoacylation for protein translation

description: The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.


cysteinyl-tRNA aminoacylation

description: The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


name: YL872_MIMIV Uncharacterized protein L872 (sprot)


name: YR871_MIMIV Uncharacterized protein R871 (sprot)


mRNA binding

description: Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.


name: YR646_MIMIV Uncharacterized protein R646 (sprot)


name: RFCS3_MIMIV Putative replication factor C small subunit L499 (sprot)


Rad17 RFC-like complex

description: A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.


Elg1 RFC-like complex

description: A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.


name: YL585_MIMIV Uncharacterized protein L585 (sprot)


name: YR596_MIMIV Probable FAD-linked sulfhydryl oxidase R596 (sprot)


name: flavin-dependent sulfhydryl oxidase activity

description: Catalysis of the reaction: [protein]-dithiol + O2 = [protein]-disulfide + H2O2 using FAD as a cofactor, leading to formation of disulfide bridges in proteins.


thiol oxidase activity

description: Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2.


flavin adenine dinucleotide binding

description: Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.


liver development

description: The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.


name: YR595_MIMIV Uncharacterized protein R595 (sprot)


lysophospholipase activity

description: Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.


acylglycerol lipase activity

description: Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.


phosphatidylserine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.


monoacylglycerol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.


name: P4H_MIMIV Putative prolyl 4-hydroxylase (sprot)


description: Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.


iron ion binding

description: Binding to an iron (Fe) ion.


name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

description: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.


L-ascorbic acid binding

description: Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.


dioxygenase activity

description: Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products.


name: YR592_MIMIV Putative helicase R592 (sprot)


name: YL591_MIMIV Uncharacterized protein L591 (sprot)


name: YR600_MIMIV Putative ankyrin repeat protein R600 (sprot)


chloroplast targeting sequence binding

description: Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.


protein targeting to chloroplast

description: The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved.


positive regulation of JNK cascade

description: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.


name: negative regulation of canonical Wnt signaling pathway

description: Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


name: YR598_MIMIV Putative ankyrin repeat protein R598 (sprot)


name: YL606_MIMIV Uncharacterized protein L606 (sprot)


name: PPIL_MIMIV Structural PPIase-like protein L605 (sprot)


name: peptidyl-prolyl cis-trans isomerase activity

description: Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).


plasma membrane

description: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.


description: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.


name: YR614_MIMIV Putative band 7 family protein R614 (sprot)


name: YL612_MIMIV Uncharacterized protein L612 (sprot)


name: YR001_MIMIV Putative replication origin-binding protein (sprot)


name: YR008_MIMIV Uncharacterized putative helicase R8 (sprot)


name: YL020_MIMIV Uncharacterized protein L20 (sprot)


name: YL018_MIMIV Putative sel1-like repeat-containing protein L18 (sprot)


ERAD pathway

description: The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.


name: YL021_MIMIV Putative sel1-like repeat-containing protein L21 (sprot)


name: YL033_MIMIV Putative KilA-N domain-containing protein L33 (sprot)


name: YL032_MIMIV Putative KilA-N domain-containing protein L32 (sprot)


name: YR040_MIMIV Uncharacterized protein R40 (sprot)


name: YL048_MIMIV Uncharacterized protein L48 (sprot)


name: YL065_MIMIV Uncharacterized protein L65 (sprot)


name: COLL1_MIMIV Collagen-like protein 1 (sprot)


name: YL068_MIMIV Uncharacterized protein L68 (sprot)


name: YR080_MIMIV Putative resolvase R80 (sprot)


DNA strand exchange activity

description: Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.


name: regulation of DNA-templated transcription

description: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.


DNA integration

description: The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.


name: YL079_MIMIV TnpB-like protein L79 (sprot)


transposition

description: Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site.


name: YL088_MIMIV Putative ankyrin repeat protein L88 (sprot)


protein localization to T-tubule

description: A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.


name: regulation of cardiac muscle contraction

description: Any process that modulates the frequency, rate or extent of cardiac muscle contraction.


T-tubule

description: Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.


name: YL086_MIMIV Putative ankyrin repeat protein L86 (sprot)


name: YL091_MIMIV Putative ankyrin repeat protein L91 (sprot)


name: YR104_MIMIV Putative transposase R104 (sprot)


name: YL103_MIMIV Putative resolvase L103 (sprot)


name: YL115_MIMIV Putative helicase L115 (sprot)


replication fork processing

description: The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.


name: YR119_MIMIV Uncharacterized protein R119 (sprot)


tyrosine-tRNA ligase activity

description: Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+.


identical protein binding

description: Binding to an identical protein or proteins.


protein homodimerization activity

description: Binding to an identical protein to form a homodimer.


L-tyrosine binding

description: Binding to L-tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid.


tyrosyl-tRNA aminoacylation

description: The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


name: YR132_MIMIV Uncharacterized protein R132 (sprot)


name: chondroitin sulfate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


name: YL128_MIMIV Putative GMC-type oxidoreductase L128 (sprot)


choline dehydrogenase activity

description: Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde.


name: oxidoreductase activity, acting on CH-OH group of donors

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


name: glycine betaine biosynthetic process from choline

description: The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline.


name: YL136_MIMIV Uncharacterized protein L136 (sprot)


description: Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose.


pyridoxal phosphate binding

description: Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.


name: YR135_MIMIV Putative GMC-type oxidoreductase R135 (sprot)


name: YR154_MIMIV Putative BTB/POZ domain and WD-repeat protein R154 (sprot)


name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.


name: YL153_MIMIV Uncharacterized protein L153 (sprot)


name: YR151_MIMIV Uncharacterized acetyltransferase R151 (sprot)


arylamine N-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.


acetyltransferase activity

description: Catalysis of the transfer of an acetyl group to an acceptor molecule.


acyltransferase activity

description: Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).


name: YR160_MIMIV Uncharacterized protein R160 (sprot)


name: YL759_MIMIV Uncharacterized protein L759 (sprot)


name: YR758_MIMIV Uncharacterized protein R758 (sprot)


5'-nucleotidase activity

description: Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.


name: pyrimidine deoxyribonucleotide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


deoxyribonucleotide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


name: YR757_MIMIV Putative F-box protein R757 (sprot)


name: YR771_MIMIV Putative resolvase R771 (sprot)


name: YL770_MIMIV TnpB-like protein L770 (sprot)


name: YL778_MIMIV Uncharacterized protein L778 (sprot)


name: YR776_MIMIV Uncharacterized protein R776 (sprot)


name: YL783_MIMIV Putative BTB/POZ domain and WD-repeat protein R783 (sprot)


microtubule binding

description: Binding to a microtubule, a filament composed of tubulin monomers.


name: YL780_MIMIV Uncharacterized protein L780 (sprot)


description: Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH.


name: methionine adenosyltransferase regulator activity

description: Binds to and modulates the activity of methionine adenosyltransferase.


description: The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.


dTDP-rhamnose biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate.


name: extracellular polysaccharide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.


methionine adenosyltransferase complex

description: A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules.


name: COLL5_MIMIV Collagen-like protein 5 (sprot)


name: COLL4_MIMIV Collagen-like protein 4 (sprot)


ATP-dependent peptidase activity

description: Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.


serine-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


serine-type peptidase activity

description: Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


protein targeting to peroxisome

description: The process of directing proteins towards the peroxisome, usually using signals contained within the protein.


protein processing

description: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.


protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


peroxisomal matrix

description: The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.


name: TF2B_MIMIV Putative transcription initiation factor IIB-like protein (sprot)


name: RNA polymerase II core promoter sequence-specific DNA binding

description: Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.


name: RNA polymerase II general transcription initiation factor activity

description: A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.


TBP-class protein binding

description: Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).


name: transcriptional start site selection at RNA polymerase II promoter

description: Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.


DNA-templated transcription initiation

description: The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.


name: transcription initiation at RNA polymerase II promoter

description: A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.


name: RNA polymerase II preinitiation complex assembly

description: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA.


name: transcription preinitiation complex assembly

description: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides.


transcription preinitiation complex

description: A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.


name: UNG_MIMIV Probable uracil-DNA glycosylase (sprot)


uracil DNA N-glycosylase activity

description: Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.


name: base-excision repair, AP site formation via deaminated base removal

description: A base-excision repair, AP site formation process occurring via excision of a deaminated base.


name: YL248_MIMIV Uncharacterized protein L248 (sprot)


name: YL247_MIMIV Uncharacterized HNH endonuclease L247 (sprot)


name: hydrolase activity, acting on ester bonds

description: Catalysis of the hydrolysis of any ester bond.


name: YL245_MIMIV Uncharacterized HNH endonuclease L245 (sprot)


name: HSP7L_MIMIV Heat shock protein 70 homolog (sprot)


ATP-dependent protein folding chaperone

description: Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.


name: endoplasmic reticulum unfolded protein response

description: The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.


name: YR253_MIMIV Uncharacterized protein R253 (sprot)


name: YR252_MIMIV Uncharacterized protein R252 (sprot)


DNA protection

description: Any process in which DNA is protected from damage by, for example, oxidative stress.


name: YL268_MIMIV Putative serine/threonine-protein kinase L268 (sprot)


name: YR266_MIMIV Putative J domain-containing protein R266 (sprot)


protein refolding

description: The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.


name: chaperone cofactor-dependent protein refolding

description: The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.


name: YL264_MIMIV Uncharacterized WD repeat-containing protein L264 (sprot)


name: YL274_MIMIV Uncharacterized protein L274 (sprot)


name: YL271_MIMIV Putative ankyrin repeat protein L271 (sprot)


name: YL280_MIMIV Uncharacterized acetyltransferase L280 (sprot)


name: YL279_MIMIV Putative ankyrin repeat protein L279 (sprot)


name: YR277_MIMIV Uncharacterized protein R277 (sprot)


name: MCAR_MIMIV Mitochondrial carrier-like protein L276 (sprot)


host cell mitochondrion

description: A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.


host cell mitochondrial inner membrane

description: The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae.


name: YL275_MIMIV Putative BTB/POZ domain-containing protein L275 (sprot)


name: YR287_MIMIV Uncharacterized protein R287 (sprot)


name: YL282_MIMIV Uncharacterized protein L282 (sprot)


name: UBPL2_MIMIV Putative ubiquitin carboxyl-terminal hydrolase L293 (sprot)


cysteine-type deubiquitinase activity

description: An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.


cysteine-type peptidase activity

description: Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


name: YR290_MIMIV Putative ATP-dependent RNA helicase R290 (sprot)


four-way junction helicase activity

description: Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis.


3'-5' DNA helicase activity

description: Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.


name: DNA unwinding involved in DNA replication

description: The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.


G-quadruplex DNA unwinding

description: The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.


chromosome

description: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.


name: YL288_MIMIV Putative B-type lectin protein L288 (sprot)


carbohydrate binding

description: Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.


name: COLL3_MIMIV Collagen-like protein 3 (sprot)


name: RPO5_MIMIV DNA-directed RNA polymerase subunit 5 (sprot)


RNA polymerase I activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


RNA polymerase II activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


RNA polymerase III activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


name: DNA-directed 5'-3' RNA polymerase activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


5'-3' RNA polymerase activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end.


transcription by RNA polymerase I

description: The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.


transcription by RNA polymerase II

description: The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).


transcription by RNA polymerase III

description: The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.


DNA-directed RNA polymerase complex

description: A protein complex that possesses DNA-directed RNA polymerase activity.


name: YL233_MIMIV Putative zinc protease L233 (sprot)


metalloendopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


name: YL294_MIMIV Uncharacterized protein L294 (sprot)


name: RNH_MIMIV Probable ribonuclease H (sprot)


name: END4_MIMIV Putative endonuclease 4 (sprot)


phosphoric diester hydrolase activity

description: Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.


name: deoxyribonuclease IV (phage-T4-induced) activity

description: Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.


name: YL300_MIMIV Uncharacterized protein L300 (sprot)


name: YR305_MIMIV Uncharacterized protein R305 (sprot)


DNA ligase (NAD+) activity

description: Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).


name: YR302_MIMIV Uncharacterized protein R302 (sprot)


name: YR301_MIMIV Putative serine/threonine-protein kinase R301 (sprot)


name: YR311_MIMIV Putative RING finger protein R311 (sprot)


name: YL310_MIMIV Uncharacterized protein L310 (sprot)


name: YL309_MIMIV Uncharacterized protein L309 (sprot)


name: YR307_MIMIV PP2C-like domain-containing protein R307 (sprot)


name: GNA1_MIMIV Probable glucosamine 6-phosphate N-acetyltransferase (sprot)


name: glucosamine 6-phosphate N-acetyltransferase activity

description: Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+.


name: acyltransferase activity, transferring groups other than amino-acyl groups

description: Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).


monosaccharide binding

description: Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


name: FPG_MIMIV Probable formamidopyrimidine-DNA glycosylase (sprot)


name: oxidized purine nucleobase lesion DNA N-glycosylase activity

description: Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.


name: hydrolase activity, acting on glycosyl bonds

description: Catalysis of the hydrolysis of any glycosyl bond.


lyase activity

description: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.


name: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

description: Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar.


name: class I DNA-(apurinic or apyrimidinic site) endonuclease activity

description: Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.


name: YL193_MIMIV Uncharacterized glycosyltransferase L193 (sprot)


name: COLL2_MIMIV Collagen-like protein 2 (sprot)


name: GLRX_MIMIV Probable glutaredoxin (sprot)


name: YR197_MIMIV Uncharacterized protein R197 (sprot)


name: YL208_MIMIV Uncharacterized protein L208 (sprot)


name: YL207_MIMIV Putative helicase L207/L206 (sprot)


name: hydrolase activity, acting on acid anhydrides

description: Catalysis of the hydrolysis of any acid anhydride.


name: YL205_MIMIV Putative serine/threonine-protein kinase L205 (sprot)


regulation of mRNA processing

description: Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.


name: RABL_MIMIV Probable Rab-related GTPase (sprot)


protein transport

description: The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of exocytosis

description: Any process that modulates the frequency, rate or extent of exocytosis.


name: YR213_MIMIV Uncharacterized protein R213 (sprot)


name: YL211_MIMIV Uncharacterized protein L211 (sprot)