{"subject": "NCBITaxon:1661386", "predicate": "biolink:subclass_of", "object": "NCBITaxon:286", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1661386", "original_object": "NCBITaxon:286"}
{"subject": "PUBCHEM.COMPOUND:44274699", "predicate": "biolink:affects", "object": "NCBIGene:5770", "affinity_parameter": "pIC50", "supporting_affinities": [6.89], "publications": ["PMID:10753467"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 6.89, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:44274699", "original_object": "UniProtKB:P18031", "object_aspect_qualifier": "activity", "object_direction_qualifier": "decreased", "qualified_predicate": "biolink:causes"}
{"subject": "NCBITaxon:1706470", "predicate": "biolink:related_to", "object": "NCBITaxon:1706470", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1706470", "original_object": "NCBITaxon:1706470"}
{"subject": "NCBIGene:3458", "predicate": "biolink:actively_involved_in", "object": "GO:0006913", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["NCBI gene2go"], "original_subject": "NCBIGene:3458", "original_object": "GO:0006913"}
{"subject": "UniProtKB:Q9R0M5-1", "predicate": "biolink:subclass_of", "object": "CHEBI:33579", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:Q9R0M5-1", "original_object": "CHEBI:33579"}
{"subject": "CHEBI:68579", "predicate": "biolink:contributes_to", "object": "MONDO:0002251", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5156547", "PMC:2730547", "PMC:5003057"], "tmkp_confidence_score": 0.6128887859621844, "sentences": "Aside from bleeding, some of the additional side effects of rivaroxaban include the following: dizziness (6%), peripheral edema (6%), hypersensitivity reactions or rash (2%), syncope (2%), and though more rare, thrombocytopenia, agranulocytosis, hepatitis, pruritis, and Stevens?Johnson syndrome.|NA|In the third patient, rivaroxaban was stopped after 23 d, when hepatitis B with seroconversion was diagnosed; the patient died of acute liver failure, mostly due to fatal hepatitis B infection, 48 d after starting treatment.|NA|Non-hemorrhagic adverse effects of rivaroxaban in the EINSTEIN-EXT study were upper abdominal pain, dyspepsia, sinusitis, tooth ache, UTI, back pain and fatigue (all less than 5%) whereas post marketing voluntary reporting of adverse effects include anaphylaxis, angioedema, Stevens-Johnson syndrome, agranulocytosis, jaundice and hepatitis.|NA", "tmkp_ids": ["tmkp:21709dfe811f66a9f620d41080651d41e3d1d379af32db099f3d5a7b494bb6cb", "tmkp:fd2d3e43f75ceac886f3de1b65395369865a1648efc1371ea27bc5b724668584", "tmkp:a62f721434da7ccccc0aee9c2709dc7e571c1caea24237d2ce5dee0cb76a9958"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB06228", "original_object": "MONDO:0002251"}
{"subject": "NCBIGene:836088", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:836392", "primary_knowledge_source": "infores:intact", "publications": "PMID:30806640", "detection_method": "MI:0892", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UniProtKB:Q9FN94", "original_object": "UniProtKB:Q8GX94"}
{"subject": "NCBITaxon:2390634", "predicate": "biolink:subclass_of", "object": "UBERON:0001062", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:2390634", "original_object": "UBERON:0001062"}
{"subject": "CHEBI:114566", "predicate": "biolink:subclass_of", "object": "CHEBI:38166", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:114566", "original_object": "CHEBI:38166"}
{"subject": "NCBIGene:1376", "predicate": "biolink:affects", "object": "PUBCHEM.COMPOUND:131757099", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P23786", "original_object": "HMDB:HMDB0046150", "object_aspect_qualifier": "abundance"}
{"object": "CHEBI:29888", "predicate": "biolink:has_participant", "subject": "SMPDB:SMP0048300", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HMDB:HMDB0000250", "original_subject": "SMPDB:SMP0048300"}
{"subject": "NCBIGene:4539", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:4728", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000354728", "original_object": "ENSEMBL:ENSP00000315774"}
{"subject": "UBERON:0001709", "predicate": "biolink:overlaps", "object": "UBERON:0001434", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001709", "original_object": "UBERON:0001434"}
{"subject": "UMLS:C3536740", "predicate": "biolink:subclass_of", "object": "UMLS:C3273258", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C101202", "original_object": "NCIT:C97151"}
{"subject": "NCBIGene:856756", "predicate": "biolink:subclass_of", "object": "CHEBI:50860", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:P40022", "original_object": "CHEBI:50860"}
{"subject": "NCBIGene:29127", "predicate": "biolink:affects", "object": "NCBIGene:1894", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:8241731", "PMC:8241731", "PMID:33485843", "PMC:6784142"], "tmkp_confidence_score": 0.97159785, "sentences": "It has also been revealed that RACGAP1 could be converted to RhoA-specific GAP by Aurora B. Others reported that RACGAP1 increased RhoA activity by stabilizing ECT2.|NA|A recent study on breast cancer revealed that RACGAP1 promotes mitochondrial dynamic driven metastasis through recruiting ECT2 and subsequently activating ERK-DRP1 pathway.|NA|We showed that RACGAP1 promoted mitochondrial fission through recruiting ECT2 during anaphase and subsequently had activated ERK-DRP1 pathway.|NA|In addition, the authors provided multiple lines of evidence to show that the GAP domain of MgcRacGAP/CYK-4 contributes to RhoA-mediated contractility, presumably through ECT2 activation.|NA", "tmkp_ids": ["tmkp:9e83192c6e107494e0354377e87f368af9627801414a32d38ca7a2bbd9f906d2", "tmkp:98023478f5073336204a684617dde1f649e287ab681bb81889e9e69365dd42f2", "tmkp:2a468305ca8e0e76cc08974c67617b3ab2855b8b89a798170b022036199485e0", "tmkp:6f0c1789bde2eeb2035cc8821640f17f50567ca5a1b90351ec29230add54baac"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "UniProtKB:Q9H0H5", "original_object": "UniProtKB:Q9H8V3"}
{"object": "REACT:R-PFA-77108", "predicate": "biolink:occurs_in", "subject": "REACT:R-PFA-74181", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-PFA-77108", "original_subject": "REACT:R-PFA-74181"}
{"subject": "NCBIGene:100153047", "predicate": "biolink:expressed_in", "object": "CL:0000023", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "not_provided", "id": "uuid:8e40f6e6-5d62-11f1-a917-cf68ef4bc185", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "file_source": "bgee_gene_to_expression_edges", "provided_by": "bgee_gene_to_expression_edges", "original_subject": "NCBIGene:100153047", "grouping_key": "NCBIGene:100153047||biolink:expressed_in|CL:0000023", "original_object": "CL:0000023"}
{"subject": "CHEBI:15367", "predicate": "biolink:affects", "object": "NCBIGene:4908", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMID:15857687", "PMID:15857687"], "tmkp_confidence_score": 0.99738718, "sentences": "We have previously shown that bone morphogenetic protein-2 (BMP2) and retinoic acid synergistically induce the responsiveness of developing sympathetic neurons to neurotrophic factors, neurotrophin 3 (NT-3), and GDNF by upregulating corresponding receptors concomitantly with the induction of other neuron-specific genes including BRINP1, a neuron-specific cell-cycle regulatory protein.|NA|We have previously shown that bone morphogenetic protein-2 (BMP2) and retinoic acid synergistically induce the responsiveness of developing sympathetic neurons to neurotrophic factors, neurotrophin 3 (NT-3), and GDNF by upregulating corresponding receptors concomitantly with the induction of other neuron-specific genes including BRINP1, a neuron-specific cell-cycle regulatory protein.|NA", "tmkp_ids": ["tmkp:49bca3d875c536a01f52821324cecc6f4f2eb2f67a8b64c2b07bd146259477ed", "tmkp:c82acfae7f1af8342d1f2c6631e6745145479574df11f63b6fa281e31aecefa0"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "DRUGBANK:DB00755", "original_object": "UniProtKB:P20783"}
{"subject": "REACT:R-SPO-191983", "predicate": "biolink:has_input", "object": "CHEBI:57783", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SPO-191983", "original_object": "CHEBI:57783"}
{"subject": "NCBIGene:534965", "predicate": "biolink:expressed_in", "object": "UBERON:0001158", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "not_provided", "id": "uuid:4719f8f8-5d62-11f1-a917-cf68ef4bc185", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "file_source": "bgee_gene_to_expression_edges", "provided_by": "bgee_gene_to_expression_edges", "original_subject": "NCBIGene:534965", "grouping_key": "NCBIGene:534965||biolink:expressed_in|UBERON:0001158", "original_object": "UBERON:0001158"}
{"subject": "NCBIGene:388", "predicate": "biolink:regulates", "object": "NCBIGene:1058", "primary_knowledge_source": "infores:lincs", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "NCBIGene:388", "original_object": "NCBIGene:1058"}
{"object": "NCBIGene:10296", "predicate": "biolink:has_part", "subject": "HGNC.FAMILY:1561", "primary_knowledge_source": "infores:hgnc", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:9763581"], "original_object": "HGNC:13731", "original_subject": "HGNC.FAMILY:1561"}
{"subject": "PANTHER.FAMILY:PTHR22884:SF473", "predicate": "biolink:actively_involved_in", "object": "GO:2001141", "primary_knowledge_source": "infores:panther", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR22884:SF473", "original_object": "GO:2001141"}
{"subject": "PUBCHEM.COMPOUND:118207377", "predicate": "biolink:related_to", "object": "NCBIGene:24410", "affinity_parameter": "pKi", "supporting_affinities": [8.8], "pubchem_assay_ids": ["PUBCHEM.AID:aid1802064"], "patent_ids": ["PATENT:US9221796"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 8.8, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:118207377", "original_object": "UniProtKB:Q00960"}
{"subject": "NCBIGene:24141", "predicate": "biolink:subclass_of", "object": "PR:000036194", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:Q9UJQ1", "original_object": "PR:000036194"}
{"subject": "CHEBI:74947", "predicate": "biolink:causes", "object": "HP:0001288", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01041", "original_object": "UMLS:C0575081"}
{"subject": "HP:0000682", "predicate": "biolink:subclass_of", "object": "HP:0000118", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000682", "original_object": "HP:0000118"}
{"object": "REACT:R-HSA-69473", "predicate": "biolink:occurs_in", "subject": "REACT:R-HSA-75035", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-HSA-69473", "original_subject": "REACT:R-HSA-75035"}
{"subject": "PANTHER.FAMILY:PTHR11706:SF52", "predicate": "biolink:located_in", "object": "GO:0098852", "primary_knowledge_source": "infores:panther", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "PANTHER.FAMILY:PTHR11706:SF52", "original_object": "GO:0098852"}
{"subject": "UBERON:0000178", "predicate": "biolink:regulates", "object": "NCBIGene:26266", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UBERON:0000178", "original_object": "NCBIGene:26266", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "downregulated", "qualified_predicate": "biolink:causes"}
{"subject": "GO:0060856", "predicate": "biolink:in_taxon", "object": "NCBITaxon:33213", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060856", "original_object": "NCBITaxon:33213"}
{"subject": "CHEBI:43401", "predicate": "biolink:subclass_of", "object": "CHEBI:24532", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:43401", "original_object": "CHEBI:24532"}
{"subject": "CL:0003027", "predicate": "biolink:subclass_of", "object": "UBERON:0001062", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0003027", "original_object": "UBERON:0001062"}
{"subject": "MONDO:0002334", "predicate": "biolink:related_to", "object": "NCBIGene:5295", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["DisGeNET"], "original_subject": "DOID:2531", "original_object": "NCBIGene:5295"}
{"subject": "MONDO:0014527", "predicate": "biolink:has_phenotype", "object": "MONDO:0020378", "primary_knowledge_source": "infores:omim", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:hpo-annotations"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "id": "uuid:6fa6aa11-7683-11f1-b7fc-6045bd002667", "category": ["biolink:DiseaseToPhenotypicFeatureAssociation", "biolink:FrequencyQuantifier", "biolink:EntityToPhenotypicFeatureAssociationMixin", "biolink:DiseaseToEntityAssociationMixin", "biolink:Association", "biolink:Entity", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin", "biolink:RelationshipQuantifier"], "file_source": "hpoa_disease_to_phenotype_edges", "provided_by": "hpoa_disease_to_phenotype_edges", "has_evidence": ["ECO:0000304"], "original_subject": "MONDO:0014527", "evidence_count": 1, "grouping_key": "MONDO:0014527|False|biolink:has_phenotype|HP:0007787", "original_object": "HP:0007787"}
{"subject": "CHEBI:43755", "predicate": "biolink:has_adverse_event", "object": "MONDO:0005609", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 30.654, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1587", "original_object": "MEDDRA:10019974"}
{"subject": "UBERON:4200084", "predicate": "biolink:subclass_of", "object": "UBERON:0004375", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:4200084", "original_object": "UBERON:0004375"}
{"subject": "NCBIGene:113235", "predicate": "biolink:increases_sensitivity_to", "object": "CHEBI:44185", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "NCBITaxon:9606", "publications": ["PMID:21879757", "PMID:25124723"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:113235", "original_object": "MESH:D008727"}
{"subject": "CHEBI:215155", "predicate": "biolink:subclass_of", "object": "CHEBI:35701", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:215155", "original_object": "CHEBI:35701"}
{"subject": "NCBIGene:6331", "predicate": "biolink:has_phenotype", "object": "MONDO:0000190", "primary_knowledge_source": "infores:hpo-annotations", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "logical_entailment", "agent_type": "automated_agent", "id": "uuid:664c7715-7683-11f1-b7fc-6045bd002667", "category": ["biolink:GeneToPhenotypicFeatureAssociation", "biolink:EntityToPhenotypicFeatureAssociationMixin", "biolink:GeneToEntityAssociationMixin", "biolink:Association", "biolink:Entity", "biolink:FrequencyQuantifier", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin", "biolink:RelationshipQuantifier"], "file_source": "hpoa_gene_to_phenotype_edges", "provided_by": "hpoa_gene_to_phenotype_edges", "disease_context_qualifier": "OMIM:603829", "original_subject": "HGNC:10593", "grouping_key": "HGNC:10593||biolink:has_phenotype|HP:0001663", "original_object": "HP:0001663"}
{"subject": "NCBIGene:6658", "predicate": "biolink:causes", "object": "MONDO:0010252", "primary_knowledge_source": "infores:omim", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "not_provided", "agent_type": "not_provided", "id": "uuid:0fd89993-6314-44de-92cf-e824840e7d04", "category": ["biolink:CausalGeneToDiseaseAssociation", "biolink:GeneToEntityAssociationMixin", "biolink:Association", "biolink:Entity"], "file_source": "omim_gene_to_disease_edges", "provided_by": "omim_gene_to_disease_edges", "original_subject": "HGNC:11199", "original_object": "MONDO:0010252", "grouping_key": "HGNC:11199||biolink:causes|MONDO:0010252"}
{"subject": "NCBIGene:8483", "predicate": "biolink:interacts_with", "object": "NCBIGene:1299", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "ENSEMBL:ENSP00000261883", "original_object": "ENSEMBL:ENSP00000496793"}
{"subject": "MONDO:0001244", "predicate": "biolink:subclass_of", "object": "HP:0032245", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0011892", "original_object": "HP:0032245"}
{"subject": "CHEBI:37941", "predicate": "biolink:regulates", "object": "NCBIGene:6241", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:60606", "original_object": "HGNC:10452", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "NCBIGene:6678", "predicate": "biolink:genetically_associated_with", "object": "MONDO:0005010", "primary_knowledge_source": "infores:ctd", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "prediction", "agent_type": "manual_agent", "original_subject": "HGNC:11219", "original_object": "DOID:3393"}
{"subject": "GO:0031829", "predicate": "biolink:subclass_of", "object": "GO:0005515", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0031829", "original_object": "GO:0005515"}
{"subject": "CHEBI:41500", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0008322", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6168010"], "tmkp_confidence_score": 1.044830170792626, "sentences": "Our first therapeutic approach to treat PSACH in our MT-COMP mouse was administration of ER stress reducing, drugs valproate, lithium and phenylbutyric acid from birth until 4 weeks after birth.|NA", "tmkp_ids": ["tmkp:a8823fbb4e8b65e6e3c7935dbbeec975cbcdf00af0948ee62768e31464156d40"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB06819", "original_object": "MONDO:0008322"}
{"subject": "PUBCHEM.COMPOUND:131781814", "predicate": "biolink:correlated_with", "object": "MONDO:0010543", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:16973164", "PMID:1719174", "PMID:10484795"], "original_subject": "HMDB:HMDB0075043", "original_object": "OMIM:302060"}
{"subject": "NCBIGene:10500", "predicate": "biolink:catalyzes", "object": "GO:0030215", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["NCBI gene2go"], "original_subject": "NCBIGene:10500", "original_object": "GO:0030215"}
{"subject": "UBERON:0016476", "predicate": "biolink:related_to", "object": "UBERON:0016476", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0016476", "original_object": "UBERON:0016476"}
{"subject": "UBERON:0003126", "predicate": "biolink:regulates", "object": "NCBIGene:84690", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UBERON:0003126", "original_object": "NCBIGene:84690", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "downregulated", "qualified_predicate": "biolink:causes"}
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{"subject": "NCIT:C56911", "predicate": "biolink:subclass_of", "object": "EFO:0009658", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C56911", "original_object": "NCIT:C41331"}
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{"subject": "CHEBI:43522", "predicate": "biolink:subclass_of", "object": "CHEBI:26151", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:43522", "original_object": "CHEBI:26151"}
{"subject": "REACT:R-CFA-9756138", "predicate": "biolink:has_output", "object": "CHEBI:180932", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-CFA-9756138", "original_object": "CHEBI:180932"}
{"subject": "REACT:R-SSC-9728150", "predicate": "biolink:has_input", "object": "NCBIGene:100286743", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SSC-9728150", "original_object": "UniProtKB:I3LKT6"}
{"subject": "CHEBI:50729", "predicate": "biolink:contributes_to", "object": "HP:0002013", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:10597740", "PMID:11851027", "PMID:15333686"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008942", "original_object": "MESH:D014839"}
{"subject": "CHEBI:3207", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0002783", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:7708268", "PMC:7708268", "PMC:7708268"], "tmkp_confidence_score": 0.9865026, "sentences": "Budesonide/formoterol significantly reduces the frequency of these events versus formoterol alone, without an associated increase in the rate of LRTI and pneumonia.|NA|Finally, we assess whether therapy with budesonide/formoterol versus formoterol alone can reduce the frequency of, and outcomes associated with, COPD symptom-related attacks, and whether this addition of an inhaled corticosteroid (ICS) to a long-acting ?2-agonist (LABA) is associated with an increased incidence of lower respiratory tract infections (LRTI) and pneumonia.|NA|In addition to highlighting the incidence and importance of COPD symptom-related attacks, our analysis also showed that adding budesonide to formoterol significantly reduces the frequency of these attacks versus formoterol alone, without the increased risk of LRTI or pneumonia.|NA", "tmkp_ids": ["tmkp:8a00e41fc8ab25edc0b73ee2df14171a9a85d036a97261e177e600e8c936111c", "tmkp:63ffc9358890913b843d836527a07b7f8bb7f8112483f4184271ea6dec6b7444", "tmkp:02732dba589fa52d1e62ebfe15ab2ce76860307bd5e97a1287347fc86611ab98"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB01222", "original_object": "HP:0002783"}
{"subject": "CHEBI:34764", "predicate": "biolink:has_adverse_event", "object": "HP:0001155", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 547.154, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1198", "original_object": "MEDDRA:10061194"}
{"subject": "NCBIGene:6927", "predicate": "biolink:genetically_associated_with", "object": "HP:0012051", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:11621", "original_object": "UMLS:C0271710"}
{"subject": "REACT:R-MMU-2022065", "predicate": "biolink:subclass_of", "object": "GO:0009306", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-MMU-2022065", "original_object": "GO:0009306"}
{"subject": "GO:0030845", "predicate": "biolink:subclass_of", "object": "GO:0065007", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030845", "original_object": "GO:0065007"}
{"subject": "CHEBI:27732", "predicate": "biolink:treats", "object": "HP:0001257", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:463", "original_object": "UMLS:C0026838"}
{"subject": "UniProtKB:P14635-1", "predicate": "biolink:coexpressed_with", "object": "UniProtKB:Q96KB5-2", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "statistical_association", "agent_type": "data_analysis_pipeline", "original_subject": "ENSEMBL:ENSP00000256442", "original_object": "ENSEMBL:ENSP00000428489"}
{"subject": "MONDO:0005662", "predicate": "biolink:associated_with", "object": "HP:0002027", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0005662", "original_object": "HP:0002027"}
{"subject": "UBERON:0035549", "predicate": "biolink:located_in", "object": "UBERON:0002199", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0035549", "original_object": "UBERON:0002199"}
{"subject": "CL:4033044", "predicate": "biolink:subclass_of", "object": "CL:0000000", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4033044", "original_object": "CL:0000000"}
{"subject": "NCBIGene:116444", "predicate": "biolink:target_for", "object": "MONDO:0005180", "primary_knowledge_source": "infores:drugcentral", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC:16768", "original_object": "DOID:14330"}
{"subject": "GO:0046520", "predicate": "biolink:has_output", "object": "CHEBI:35785", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0046520", "original_object": "CHEBI:35785"}
{"subject": "UNII:K2J09EMJ52", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0032981", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2120", "original_object": "UMLS:C0032981"}
{"subject": "CHEBI:4315", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:2798", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["DrugBank (target)"], "original_subject": "DRUGBANK:DB01406", "original_object": "NCBIGene:2798"}
{"subject": "NCBIGene:6201", "predicate": "biolink:coexpressed_with", "object": "NCBIGene:6227", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000495273", "original_object": "ENSEMBL:ENSP00000345957"}
{"subject": "CHEBI:60553", "predicate": "biolink:subclass_of", "object": "CHEBI:60027", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:60553", "original_object": "CHEBI:60027"}
{"subject": "GO:0060077", "predicate": "biolink:subclass_of", "object": "UBERON:0000465", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060077", "original_object": "UBERON:0000465"}
{"subject": "GO:0001537", "predicate": "biolink:has_participant", "object": "CHEBI:58339", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001537", "original_object": "CHEBI:58339"}
{"subject": "UBERON:0014612", "predicate": "biolink:in_taxon", "object": "NCBITaxon:7742", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0014612", "original_object": "NCBITaxon:7742"}
{"subject": "CHEBI:231347", "predicate": "biolink:related_to", "object": "CHEBI:38157", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:231347", "original_object": "CHEBI:38157"}
{"subject": "NCBIGene:513958", "predicate": "biolink:contributes_to", "object": "GO:0005085", "primary_knowledge_source": "infores:go", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["GO_REF:0000033"], "id": "uuid:43cfcd22-7cc4-11f1-8048-c96a56557525", "category": ["biolink:MacromolecularMachineToMolecularActivityAssociation", "biolink:MacromolecularMachineToEntityAssociationMixin", "biolink:FunctionalAssociation", "biolink:Association", "biolink:Entity"], "file_source": "go_annotation_edges", "provided_by": "go_annotation_edges", "has_evidence": ["ECO:0000318"], "species_context_qualifier": "NCBITaxon:9913", "original_subject": "NCBIGene:513958", "evidence_count": 2, "grouping_key": "NCBIGene:513958|False|biolink:contributes_to|GO:0005085", "original_object": "GO:0005085"}
{"subject": "CL:4052011", "predicate": "biolink:temporally_related_to", "object": "GO:0048513", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4052011", "original_object": "GO:0048513"}
{"subject": "MESH:D014028", "predicate": "biolink:contributes_to", "object": "MONDO:0005302", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:34014325"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014028", "original_object": "MESH:D001289"}
{"subject": "UBERON:0007685", "predicate": "biolink:subclass_of", "object": "UBERON:0000061", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0007685", "original_object": "UBERON:0000061"}
{"object": "PANTHER.FAMILY:PTHR10405:SF33", "predicate": "biolink:has_part", "subject": "PANTHER.FAMILY:PTHR10405", "primary_knowledge_source": "infores:panther", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_object": "PANTHER.FAMILY:PTHR10405:SF33", "original_subject": "PANTHER.FAMILY:PTHR10405"}
{"subject": "CHEBI:25681", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0040270", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:2705820", "PMC:4886737", "PMC:5067287", "PMC:6522756"], "tmkp_confidence_score": 0.9020263, "sentences": "The Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial was the first large study to investigate the efficacy of long-term omega-3 fatty acid supplementation on cardiovascular events in individuals with CVD plus impaired glucose tolerance, impaired fasting glucose, or diabetes.|NA", "tmkp_ids": ["tmkp:809b7db9c7b7a0570e149645e1b016f3ec283a52dde3109e13574152b6dc0d51", "tmkp:9d3af4e05f503a5ad6cce5c334cc7694722ff97aaf76cf81c4f234ac3b7dcf9b", "tmkp:bd2736b9453a799e77b82f2057c75b43eca3eb81c67a9acaebbf06b894ce322e", "tmkp:cbb1f03888ef223807cf0d6356cbde9d401e119a3c9e518997c2d20d3f6bcfe1", "tmkp:ef2128a46b6b423549013e1484638bf27648f58b7313e8e42fb4d2aebfed4370"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "CHEBI:25681", "original_object": "HP:0040270"}
{"subject": "PUBCHEM.COMPOUND:9551646", "predicate": "biolink:affects", "object": "NCBIGene:1557", "primary_knowledge_source": "infores:pharos", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 6.8, "affinity_parameter": "pAC50", "original_subject": "CHEMBL.COMPOUND:CHEMBL1594359", "original_object": "HGNC:2621", "object_aspect_qualifier": "activity", "object_direction_qualifier": "increased", "qualified_predicate": "biolink:causes"}
{"subject": "NCBIGene:2268", "predicate": "biolink:colocalizes_with", "object": "GO:0015629", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:P09769", "original_object": "GO:0015629"}
{"subject": "PUBCHEM.COMPOUND:11431811", "predicate": "biolink:similar_to", "object": "CHEBI:135361", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB01409", "original_object": "DRUGBANK:DB00462"}
{"subject": "PANTHER.PATHWAY:P06664", "predicate": "biolink:has_participant", "object": "PANTHER.FAMILY:PTHR23255:SF63", "primary_knowledge_source": "infores:panther", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "PANTHER.PATHWAY:P06664", "original_object": "PANTHER.FAMILY:PTHR23255:SF63"}
{"subject": "UMLS:C1516729", "predicate": "biolink:subclass_of", "object": "UBERON:0001981", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C32361", "original_object": "NCIT:C12679"}
{"subject": "REACT:R-CEL-71130", "predicate": "biolink:has_output", "object": "CHEBI:59560", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-CEL-71130", "original_object": "CHEBI:59560"}
{"object": "UBERON:0015479", "predicate": "biolink:has_part", "subject": "UBERON:0001300", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0015479", "original_subject": "UBERON:0001300"}
{"subject": "CHEBI:25879", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0234976", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2085", "original_object": "UMLS:C0234976"}
{"subject": "UNII:H4C81M8YYW", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:3286", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:24771824", "original_object": "PUBCHEM.COMPOUND:54746"}
{"object": "CL:0000861", "predicate": "biolink:has_participant", "subject": "GO:0006954", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0000861", "original_subject": "GO:0006954"}
{"subject": "CL:0007004", "predicate": "biolink:related_to", "object": "CL:0007004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0007004", "original_object": "CL:0007004"}
{"subject": "CHEBI:16134", "predicate": "biolink:related_to", "object": "NCBIGene:259307", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HMDB:HMDB0000051", "original_object": "UniProtKB:Q96RQ9"}
{"subject": "REACT:R-BTA-6784791", "predicate": "biolink:has_output", "object": "UniProtKB:F1MX38", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-BTA-6784791", "original_object": "UniProtKB:F1MX38"}
{"subject": "GO:0016122", "predicate": "biolink:has_participant", "object": "CHEBI:27325", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0016122", "original_object": "CHEBI:27325"}
{"subject": "REACT:R-MMU-69183", "predicate": "biolink:precedes", "object": "REACT:R-MMU-69091", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-MMU-69183", "original_object": "REACT:R-MMU-69091"}
{"object": "UBERON:0002013", "predicate": "biolink:has_part", "subject": "UBERON:0005303", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "EMAPA:19274", "original_subject": "EMAPA:18225"}
{"object": "GO:0001744", "predicate": "biolink:has_part", "subject": "GO:0001748", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0001744", "original_subject": "GO:0001748"}
{"subject": "GO:0005381", "predicate": "biolink:has_input", "object": "CHEBI:24875", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005381", "original_object": "CHEBI:24875"}
{"subject": "CHEBI:38495", "predicate": "biolink:contributes_to", "object": "HP:0005162", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5789123"], "tmkp_confidence_score": 1.3673890925739316, "sentences": "They reported that AlP intoxication was associated with left ventricular dysfunction, low ejection fraction, severe hypotension and electrocardiographic abnormalities.|NA", "tmkp_ids": ["tmkp:98008fe5edda95a1518722fd6159c5f650dfffd42f971ec9cca68ef2a7f87d70"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "CHEBI:38495", "original_object": "HP:0005162"}
{"subject": "CHEBI:81064", "predicate": "biolink:subclass_of", "object": "CHEBI:17334", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:81064", "original_object": "CHEBI:17334"}
{"subject": "UBERON:0004983", "predicate": "biolink:in_taxon", "object": "NCBITaxon:7742", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004983", "original_object": "NCBITaxon:7742"}
{"subject": "CHEBI:42797", "predicate": "biolink:applied_to_treat", "object": "HP:0000989", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1264", "original_object": "UMLS:C0033774"}
{"subject": "UBERON:0036212", "predicate": "biolink:coexists_with", "object": "UBERON:0010887", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0036212", "original_object": "UBERON:0010887"}
{"subject": "PANTHER.FAMILY:PTHR45655:SF17", "predicate": "biolink:actively_involved_in", "object": "GO:0019934", "primary_knowledge_source": "infores:panther", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR45655:SF17", "original_object": "GO:0019934"}
{"subject": "REACT:R-HSA-8876993", "predicate": "biolink:has_output", "object": "NCBIGene:1500", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-8876993", "original_object": "UniProtKB:O60716"}
{"subject": "UMLS:C0167117", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0001410", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:7475780"], "tmkp_confidence_score": 1.165616253601696, "sentences": "Indeed, exenatide exerts hepato-protective as well as glucose-lowering actions combined with remarkable amelioration of anthropometric parameters and liver dysfunction markers.|NA", "tmkp_ids": ["tmkp:d504b32df3114d624069927929ac0cb52581fde4d5af0963cac59efa862f1afe"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB01276", "original_object": "HP:0001410"}
{"subject": "NCBIGene:40901", "predicate": "biolink:decreases_sensitivity_to", "object": "CHEBI:141474", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "NCBITaxon:30069", "publications": ["PMID:10692012", "PMID:3507466"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:40901", "original_object": "MESH:D008294"}
{"subject": "GO:0062153", "predicate": "biolink:has_part", "object": "GO:0003723", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0062153", "original_object": "GO:0003723"}
{"subject": "GO:0098564", "predicate": "biolink:related_to", "object": "GO:0098564", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098564", "original_object": "GO:0098564"}
{"subject": "UBERON:0002959", "predicate": "biolink:related_to", "object": "UBERON:0015233", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002959", "original_object": "UBERON:0015233"}
{"subject": "CHEBI:16347", "predicate": "biolink:correlated_with", "object": "MONDO:0009520", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:6157502", "PMID:11129331", "PMID:28583327", "PMID:15505778", "PMID:25557019", "PMID:23705938", "PMID:1886403", "PMID:12072887", "PMID:19893767"], "original_subject": "HMDB:HMDB0000062", "original_object": "OMIM:246450"}
{"subject": "REACT:R-HSA-4341669", "predicate": "biolink:has_input", "object": "CHEBI:15377", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-4341669", "original_object": "CHEBI:15377"}
{"object": "GO:0019164", "predicate": "biolink:has_part", "subject": "GO:0006086", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0019164", "original_subject": "GO:0006086"}
{"subject": "UBERON:0003008", "predicate": "biolink:temporally_related_to", "object": "GO:0016331", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003008", "original_object": "GO:0016331"}
{"subject": "GO:1902200", "predicate": "biolink:has_output", "object": "CHEBI:57344", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1902200", "original_object": "CHEBI:57344"}
{"subject": "NCBIGene:5743", "predicate": "biolink:affects", "object": "CHEBI:44185", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMID:32254955"], "tmkp_confidence_score": 0.99970764, "sentences": "And, in vivo, multifunctional Pd-Cys@MTX@RGD effectively inhibited the symptoms of RA by inhibiting the expression of pro-inflammatory cytokines (TNF-?,COX-2).|NA", "tmkp_ids": ["tmkp:cf42a86f60d5dedb6570f49869d9f1180dce206785396a07afacebc174362d8f"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "decreased", "original_subject": "UniProtKB:P35354", "original_object": "DRUGBANK:DB00563"}
{"subject": "CHEBI:32127", "predicate": "biolink:has_adverse_event", "object": "HP:0001336", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 26.898, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4324", "original_object": "MEDDRA:10028622"}
{"subject": "GO:0140167", "predicate": "biolink:has_output", "object": "GO:0035363", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0140167", "original_object": "GO:0035363"}
{"subject": "UBERON:0011628", "predicate": "biolink:related_to", "object": "UBERON:0010313", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0011628", "original_object": "UBERON:0010313"}
{"subject": "NCBIGene:25903", "predicate": "biolink:genetically_associated_with", "object": "UMLS:C0023893", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:24558", "original_object": "UMLS:C0023893"}
{"object": "GO:0008033", "predicate": "biolink:occurs_in", "subject": "REACT:R-BTA-6782315", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0008033", "original_subject": "REACT:R-BTA-6782315"}
{"subject": "UBERON:0010404", "predicate": "biolink:related_to", "object": "GO:0050877", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010404", "original_object": "GO:0050877"}
{"subject": "GO:0010476", "predicate": "biolink:subclass_of", "object": "GO:0007165", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0010476", "original_object": "GO:0007165"}
{"subject": "CHEBI:85146", "predicate": "biolink:related_to", "object": "CHEBI:18246", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:85146", "original_object": "CHEBI:18246"}
{"subject": "UMLS:C5708041", "predicate": "biolink:affects", "object": "UMLS:C0039195", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C188801", "original_object": "NCIT:C12543"}
{"subject": "UNII:9430ZR8ZAN", "predicate": "biolink:causes", "object": "MONDO:0005492", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB06705", "original_object": "UMLS:C0042109"}
{"subject": "MONDO:1010755", "predicate": "biolink:in_taxon", "object": "NCBITaxon:9913", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:1010755", "original_object": "NCBITaxon:9913"}
{"subject": "UBERON:0003700", "predicate": "biolink:located_in", "object": "UBERON:0000165", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003700", "original_object": "UBERON:0000165"}
{"subject": "UBERON:0011255", "predicate": "biolink:overlaps", "object": "GO:0005622", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0011255", "original_object": "GO:0005622"}
{"subject": "HP:0031461", "predicate": "biolink:affects", "object": "UBERON:0001015", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C6579", "original_object": "NCIT:C13056"}
{"subject": "CHEBI:16070", "predicate": "biolink:related_to", "object": "CHEBI:17924", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16070", "original_object": "CHEBI:17924"}
{"subject": "CHEBI:52033", "predicate": "biolink:has_part", "object": "CHEBI:52820", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:52033", "original_object": "CHEBI:52820"}
{"object": "GO:0007091", "predicate": "biolink:occurs_in", "subject": "REACT:R-HSA-163010", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-HSA-68881", "original_subject": "REACT:R-HSA-163010"}
{"subject": "CHEBI:50931", "predicate": "biolink:similar_to", "object": "CHEBI:135295", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB01239", "original_object": "DRUGBANK:DB01511"}
{"subject": "CL:0000613", "predicate": "biolink:related_to", "object": "PR:000002065", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000613", "original_object": "PR:000002065"}
{"subject": "GO:0047620", "predicate": "biolink:related_to", "object": "GO:0047620", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0047620", "original_object": "GO:0047620"}
{"subject": "NCBIGene:9855", "predicate": "biolink:affects", "object": "GO:0016601", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:12351724"], "original_subject": "UniProtKB:O94887", "original_object": "GO:0016601"}
{"subject": "CL:4023113", "predicate": "biolink:overlaps", "object": "GO:0045202", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4023113", "original_object": "GO:0045202"}
{"subject": "GO:0062078", "predicate": "biolink:has_input", "object": "GO:0033596", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0062078", "original_object": "GO:0033596"}
{"subject": "PUBCHEM.COMPOUND:44422696", "predicate": "biolink:related_to", "object": "NCBIGene:1132", "affinity_parameter": "pKi", "supporting_affinities": [4.34], "publications": ["PMID:18077164"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 4.34, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:44422696", "original_object": "UniProtKB:P08173"}
{"subject": "HP:0002098", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002046", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00822_MESH_D000437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002098", "original_object": "MESH:D000437"}
{"subject": "NCBIGene:213", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0010604", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5269444", "PMC:5269444", "PMC:7467451", "PMC:7467451", "PMC:8362221"], "tmkp_confidence_score": 0.7510764686879398, "sentences": "These results demonstrate improved correction of hemophilia B using AAV vectors pre-incubated with HSA, and also suggest possible utilization of this formulation to increase efficacy at lower vector doses for the treatment of hemophilia and other diseases.|NA|Improved phenotypic correction of hemophilia B using human albumin to enhance AAV vector transduction|NA|An extended half-life fusion protein linking recombinant FIX (rFIX) with human albumin (rIX-FP) has been developed for the treatment of patients with haemophilia B and is indicated for dosing up to every 14?days.|NA|This study looked at the use of an extended half-life fusion protein linking recombinant FIX (rFIX) with human albumin (rIX-FP), which was designed to allow longer dosing intervals, in patients with haemophilia B in Italy, Belgium and the UK, and compared this with the patients? previous FIX product.|NA|The short half?life of coagulation factor IX (FIX) for haemophilia B (HB) therapy has been prolonged through fusion with human serum albumin (HSA), which drives the neonatal Fc receptor (FcRn)?mediated recycling of the chimera.|NA", "tmkp_ids": ["tmkp:ea6077357b87d83e75591a3f05a9b23dfbd36bd2bef7d5d6b1ed1b6f7f413490", "tmkp:c5fe9040a43a41e353ab8e1292a19f77db8d07a1965b97337c673d0bf92e545d", "tmkp:6d51739a0b3e8896689128e28e893c10dbce882dc01c65e0b1eb8384f65239aa", "tmkp:808d4496d401416444223e8287801d6655880b5113d86b2dae8910afa8dde67c", "tmkp:aaea7629bde1e50035ac706ae62a60850a01f58825ec1e574a59f55a85c95925"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00062", "original_object": "MONDO:0010604"}
{"subject": "CHEBI:25944", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005093", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:11665844", "PMID:15858460"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010575", "original_object": "MESH:D012871"}
{"subject": "UNII:9JD9B4S53T", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0016262", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9180633", "PMC:9180633", "PMC:9180633", "PMC:9180633", "PMC:9180633"], "tmkp_confidence_score": 0.99948324, "sentences": "In uLMS cells, DAPT and MK-0752 decreased Notch signaling in a dose- and time-dependent manner.|NA|DAPT and MK-0752 Decrease uLMS Cell Viability|NA|Taken together, our findings demonstrate that DAPT is more effective than MK-0752 at reducing Notch signaling activity in uLMS cells, but neither GSI decreases uLMS cell proliferation or invasion, which are required for tumor progression.|NA|Exposure of SK-UT-1B and SK-LMS-1 to DAPT and MK-0752 decreased expression of HES1 and decreased uLMS cell viability in a dose- and time-dependent manner that was unique to each GSI.|NA|MK-0752, which is orally tolerated, should be investigated in 3D in vitro and in vivo models, either alone or in combination with other cytotoxic agents, to further assess efficacy as a potential therapeutic modality against uLMS.|NA", "tmkp_ids": ["tmkp:0de2a52300f83b6d5675b2a02cee3342ffd764a64aca30dcc03f9df683f8d5c2", "tmkp:8344109c65dc7c3507b03184fd603ac5810550e4c9d10a46ae01eb96055e0cde", "tmkp:8c95a620a9fb15757b97abb9d50d5962e4b9fa528d19577a5f9223259be5d136", "tmkp:481fc3bd2a5b21b43d1ff52a7a15108af83ba3d13671910a3767527119dce62a", "tmkp:0838bc6be36003f53ad506104e1c69a64a23a9ad4f07b6a79615833b66decf44"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB12852", "original_object": "HP:0002891"}
{"subject": "GO:0009532", "predicate": "biolink:in_taxon", "object": "NCBITaxon:131567", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009532", "original_object": "NCBITaxon:131567"}
{"subject": "CHEBI:91829", "predicate": "biolink:regulates", "object": "NCBIGene:55859", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:22565", "original_object": "HGNC:1036", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "UNII:C3574QBZ3Y", "predicate": "biolink:contributes_to", "object": "EFO:0009426", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:24503009"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C028007", "original_object": "MESH:D009336"}
{"subject": "GO:0015765", "predicate": "biolink:has_input", "object": "CHEBI:60982", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015765", "original_object": "CHEBI:60982"}
{"subject": "UNII:Q5EN532NE7", "predicate": "biolink:preventative_for_condition", "object": "GO:0090592", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01280_MESH_D054218_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C022206", "original_object": "GO:0090592"}
{"subject": "CHEBI:119915", "predicate": "biolink:causes", "object": "UMLS:C0235146", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00813", "original_object": "UMLS:C0235146"}
{"subject": "GO:0030073", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002909", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00222_MESH_D003924_1", "DB00672_MESH_D003924_1", "DB00731_MESH_D003924_1", "DB00839_MESH_D003924_1", "DB01016_MESH_D003924_1", "DB01120_MESH_D003924_1", "DB01124_MESH_D003924_1", "DB01289_MESH_D003924_1", "DB08962_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030073", "original_object": "HP:0003074"}
{"subject": "UBERON:0009975", "predicate": "biolink:related_to", "object": "GO:0050877", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0009975", "original_object": "GO:0050877"}
{"subject": "MONDO:0002367", "predicate": "biolink:similar_to", "object": "MONDO:0005089", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["MEDLINE cooccurrence"], "original_subject": "DOID:263", "original_object": "DOID:1115"}
{"subject": "UBERON:0002233", "predicate": "biolink:related_to", "object": "UBERON:0002276", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002233", "original_object": "UBERON:0002276"}
{"subject": "CHEBI:102265", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0032981", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2502", "original_object": "UMLS:C0032981"}
{"subject": "CHEBI:5134", "predicate": "biolink:subclass_of", "object": "CHEBI:77166", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:31441", "original_object": "CHEBI:77166"}
{"subject": "MONDO:0100096", "predicate": "biolink:has_part", "object": "NCBIGene:59272", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "complex_context": ["S1 trimer:ACE2:S2 trimer", "S1:ACE2", "S3:M:E:encapsidated  SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs", "S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2", "Spike trimer:ACE2"], "original_subject": "DOID:0080600", "original_object": "UniProtKB:Q9BYF1"}
{"subject": "CHEBI:180472", "predicate": "biolink:subclass_of", "object": "CHEBI:17996", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:180472", "original_object": "CHEBI:23114"}
{"subject": "NCBIGene:79001", "predicate": "biolink:decreases_sensitivity_to", "object": "CHEBI:50249", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "NCBITaxon:10116", "publications": ["PMID:19890940"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:79001", "original_object": "MESH:D000925"}
{"subject": "CHEBI:3398", "predicate": "biolink:contraindicated_in", "object": "HP:0200119", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:499", "original_object": "UMLS:C0267797"}
{"subject": "CHEBI:91083", "predicate": "biolink:related_to", "object": "CHEBI:17920", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:91083", "original_object": "CHEBI:17920"}
{"subject": "GO:0051958", "predicate": "biolink:has_input", "object": "CHEBI:50681", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0051958", "original_object": "CHEBI:50681"}
{"subject": "UMLS:C5555759", "predicate": "biolink:affects", "object": "UBERON:0012332", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C179547", "original_object": "NCIT:C12318"}
{"object": "MONDO:0000306", "predicate": "biolink:causes", "subject": "NCBITaxon:5552", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0000306", "original_subject": "NCBITaxon:5552"}
{"subject": "CHEBI:49662", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005178", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00328", "original_object": "DOID:8398"}
{"subject": "GO:0019226", "predicate": "biolink:related_to", "object": "GO:0045202", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019226", "original_object": "GO:0045202"}
{"subject": "CHEBI:8481", "predicate": "biolink:causes", "object": "UMLS:C0039971", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00782", "original_object": "UMLS:C0039971"}
{"subject": "GO:0047533", "predicate": "biolink:has_participant", "object": "CHEBI:15377", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0047533", "original_object": "CHEBI:15377"}
{"subject": "GO:0009273", "predicate": "biolink:occurs_in", "object": "NCBITaxon:139", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01112_MESH_D008193_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009273", "original_object": "NCBITaxon:139"}
{"subject": "MONDO:0002095", "predicate": "biolink:related_to", "object": "UMLS:C1708871", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C7390", "original_object": "NCIT:C47834"}
{"subject": "REACT:R-BTA-75244", "predicate": "biolink:subclass_of", "object": "GO:0097190", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-BTA-75244", "original_object": "GO:0097190"}
{"subject": "CHEBI:17561", "predicate": "biolink:similar_to", "object": "CHEBI:15729", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00151", "original_object": "DRUGBANK:DB00129"}
{"subject": "CL:4033038", "predicate": "biolink:related_to", "object": "GO:0007585", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4033038", "original_object": "GO:0007585"}
{"subject": "UMLS:C2826229", "predicate": "biolink:contributes_to", "object": "HP:0003326", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6601617"], "tmkp_confidence_score": 1.2497003426605344, "sentences": "Adverse events occurring more frequently in the ado-trastuzumab emtansine group than in the lapatinib plus capecitabine group included thrombo-cytopenia (31% vs 3%), constipation (27% vs 11%), increased amino transferase levels (29% vs 14%), headache (28% vs 15%), epistaxis (23% vs 8%), arthralgia (19% vs 8%), pyrexia (19% vs 8%), dry mouth (17% vs 5%), and myalgia (14% vs 4%).|NA", "tmkp_ids": ["tmkp:8fdf1c841e8c1bcd215311f8d96f2953f8e11c41f38a9d3dbbc763e3f572d21c"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB05773", "original_object": "HP:0003326"}
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{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0015758", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00959_MESH_D009182_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "HP:0012192"}
{"subject": "CHEBI:133354", "predicate": "biolink:has_part", "object": "CHEBI:133353", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:133354", "original_object": "CHEBI:133353"}
{"subject": "HP:0012465", "predicate": "biolink:occurs_in", "object": "MONDO:0019402", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01609_MESH_D017086_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012465", "original_object": "MESH:D017086"}
{"subject": "MESH:D010936", "predicate": "biolink:affects", "object": "NCBIGene:3586", "primary_knowledge_source": "infores:ctd", "description": "increases secretion of", "taxon": "NCBITaxon:10090", "publications": ["PMID:21804081"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010936", "original_object": "NCBIGENE:3586", "object_aspect_qualifier": "secretion", "object_direction_qualifier": "increased", "qualified_predicate": "biolink:causes"}
{"subject": "CHEBI:2533", "predicate": "biolink:affects", "object": "MONDO:0008315", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:27917368"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:C000188", "original_object": "MESH:D011471"}
{"subject": "MONDO:0005036", "predicate": "biolink:disease_has_basis_in", "object": "REACT:R-HSA-9710468", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DOID:3717", "original_object": "REACT:R-HSA-9710468"}
{"subject": "CHEBI:22977", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005258", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:33765546"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D002104", "original_object": "MESH:D000067877"}
{"object": "CL:1001320", "predicate": "biolink:has_part", "subject": "UBERON:0000057", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:1001320", "original_subject": "UBERON:0000057"}
{"subject": "CL:0003011", "predicate": "biolink:overlaps", "object": "UBERON:0001016", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0003011", "original_object": "UBERON:0001016"}
{"subject": "CL:0002461", "predicate": "biolink:develops_from", "object": "CL:0002010", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0002461", "original_object": "CL:0002010"}
{"subject": "CL:0002400", "predicate": "biolink:in_taxon", "object": "NCBITaxon:10090", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0002400", "original_object": "NCBITaxon:10090"}
{"subject": "CHEBI:47308", "predicate": "biolink:related_to", "object": "CHEBI:27856", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:47308", "original_object": "CHEBI:27856"}
{"subject": "CL:0003016", "predicate": "biolink:overlaps", "object": "UBERON:0000019", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0003016", "original_object": "UBERON:0000019"}
{"subject": "CHEBI:63620", "predicate": "biolink:causes", "object": "UMLS:C0022650", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01367", "original_object": "UMLS:C0022650"}
{"subject": "MESH:D010936", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0005240", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:15267137", "PMID:15577213", "PMID:16671961", "PMID:17132217", "PMID:17135156", "PMID:17385802", "PMID:19952499", "PMID:19960953", "PMID:21939360", "PMID:32651782"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010936", "original_object": "MESH:D007674"}
{"subject": "PUBCHEM.COMPOUND:45105040", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:10855", "primary_knowledge_source": "infores:pharos", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 6.44, "affinity_parameter": "pKd", "publications": ["PMID:20128596"], "original_subject": "CHEMBL.COMPOUND:CHEMBL590011", "original_object": "HGNC:5164"}
{"subject": "UBERON:0005381", "predicate": "biolink:overlaps", "object": "UBERON:0002304", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0005381", "original_object": "UBERON:0002304"}
{"subject": "NCBIGene:7299", "predicate": "biolink:regulates", "object": "GO:0008283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00548_MESH_D000152_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P14679", "original_object": "GO:0008283"}
{"subject": "CHEBI:194308", "predicate": "biolink:subclass_of", "object": "CHEBI:48601", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:194308", "original_object": "CHEBI:48601"}
{"object": "REACT:R-SCE-8978868", "predicate": "biolink:occurs_in", "subject": "GO:0006853", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-SCE-8978868", "original_subject": "GO:0006853"}
{"subject": "GO:0030219", "predicate": "biolink:causes", "object": "CL:0000556", "primary_knowledge_source": "infores:go", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:phenio"], "knowledge_level": "not_provided", "agent_type": "not_provided", "id": "urn:uuid:2f333c79-af06-4c37-be01-c625dccd823d", "category": ["biolink:Association", "biolink:Entity"], "file_source": "phenio_edges", "provided_by": "phenio_edges", "original_predicate": "RO:0002315", "grouping_key": "GO:0030219||biolink:causes|CL:0000556", "original_subject": "GO:0030219", "original_object": "CL:0000556"}
{"subject": "CHEBI:77779", "predicate": "biolink:has_part", "object": "CHEBI:77782", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:77779", "original_object": "CHEBI:77782"}
{"subject": "MONDO:0044626", "predicate": "biolink:has_participant", "object": "GO:0019953", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0044626", "original_object": "GO:0019953"}
{"subject": "NCBIGene:5915", "predicate": "biolink:negatively_correlated_with", "object": "NCBIGene:1956", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00799_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P10826", "original_object": "UniProtKB:P00533"}
{"subject": "MONDO:0018940", "predicate": "biolink:disease_has_basis_in", "object": "REACT:R-HSA-4549349", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DOID:3635", "original_object": "REACT:R-HSA-4549349"}
{"subject": "CHEBI:86975", "predicate": "biolink:related_to", "object": "CHEBI:28842", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:86975", "original_object": "CHEBI:28842"}
{"subject": "GO:0060157", "predicate": "biolink:has_output", "object": "UBERON:0001255", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060157", "original_object": "UBERON:0001255"}
{"subject": "REACT:R-HSA-9607240", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0020334", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06595_MESH_D007946_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-9607240", "original_object": "MESH:D007946"}
{"subject": "CHEBI:8428", "predicate": "biolink:related_to", "object": "CHEBI:50427", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:8428", "original_object": "CHEBI:50427"}
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{"subject": "NCBIGene:9429", "predicate": "biolink:affects_sensitivity_to", "object": "CHEBI:10033", "primary_knowledge_source": "infores:ctd", "description": "affects response to", "taxon": "NCBITaxon:9606", "publications": ["PMID:25300812"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:9429", "original_object": "MESH:D014859"}
{"subject": "UMLS:C0854802", "predicate": "biolink:related_to", "object": "MESH:D002896", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C8645", "original_object": "NCIT:C13222"}
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{"subject": "CHEBI:165220", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0018908", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:22328999"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:C410127", "original_object": "MESH:D008228"}
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{"subject": "HP:0000969", "predicate": "biolink:manifestation_of", "object": "MONDO:0007243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01234_MESH_D002051_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000969", "original_object": "MESH:D002051"}
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{"subject": "CHEBI:29034", "predicate": "biolink:located_in", "object": "CHEBI:35143", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08826_MESH_D017086_1", "DB08826_MESH_D019190_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:29034", "original_object": "CHEBI:35143"}
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{"subject": "UBERON:3000036", "predicate": "biolink:overlaps", "object": "UBERON:0003128", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:3000036", "original_object": "UBERON:0003128"}
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{"subject": "UBERON:0006669", "predicate": "biolink:overlaps", "object": "UBERON:0004537", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0006669", "original_object": "UBERON:0004537"}
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{"subject": "CHEBI:50275", "predicate": "biolink:applied_to_treat", "object": "UMLS:C0041909", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1055", "original_object": "UMLS:C0041909"}
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{"subject": "CHEBI:133980", "predicate": "biolink:subclass_of", "object": "CHEBI:33241", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:133980", "original_object": "CHEBI:33241"}
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{"subject": "CHEBI:81881", "predicate": "biolink:related_to", "object": "CHEBI:26155", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:81881", "original_object": "CHEBI:26155"}
{"subject": "UMLS:C0657912", "predicate": "biolink:causes", "object": "HP:0000613", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00230", "original_object": "UMLS:C0085636"}
{"subject": "CHEBI:50378", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:94501", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:115355", "original_object": "PUBCHEM.COMPOUND:5284566"}
{"subject": "UNII:76JZE5DSN6", "predicate": "biolink:contributes_to", "object": "HP:0002015", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9088458"], "tmkp_confidence_score": 0.99887985, "sentences": "An elderly female in her late 50s with a medical history of hypertension, developed acute onset facial puffiness, dysphagia, tongue, and neck swelling, with onset 1 week after the first dose of the BBV152 vaccine.|NA", "tmkp_ids": ["tmkp:51581b2716ebb0f9c05029fcc784614830f4e5f71331743f739e9cddec54b74b"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB15847", "original_object": "HP:0002015"}
{"subject": "CHEBI:52446", "predicate": "biolink:has_part", "object": "CHEBI:52527", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:52446", "original_object": "CHEBI:52527"}
{"subject": "GO:0018104", "predicate": "biolink:contributes_to", "object": "GO:0005618", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01333_MESH_D012141_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0018104", "original_object": "GO:0005618"}
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{"subject": "GO:1901696", "predicate": "biolink:has_output", "object": "CHEBI:67194", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1901696", "original_object": "CHEBI:67194"}
{"subject": "CHEBI:131804", "predicate": "biolink:related_to", "object": "CHEBI:131805", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:131804", "original_object": "CHEBI:131805"}
{"subject": "CHEMBL.COMPOUND:CHEMBL426414", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:1814", "primary_knowledge_source": "infores:pharos", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 8.1, "affinity_parameter": "pKd", "publications": ["PMID:16335915"], "original_subject": "CHEMBL.COMPOUND:CHEMBL426414", "original_object": "HGNC:3024"}
{"subject": "MONDO:0019145", "predicate": "biolink:has_participant", "object": "GO:0004252", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0019145", "original_object": "GO:0004252"}
{"subject": "MESH:C515928", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0012534", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:16982702"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C515928", "original_object": "MESH:D006930"}
{"subject": "GO:0008900", "predicate": "biolink:positively_correlated_with", "object": "GO:0001696", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00736_MESH_D004942_1", "DB00736_MESH_D010437_1", "DB00736_MESH_D015043_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008900", "original_object": "GO:0001696"}
{"subject": "MONDO:0044784", "predicate": "biolink:related_to", "object": "NCIT:C9478", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C6577", "original_object": "NCIT:C9478"}
{"subject": "GO:0008217", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0005044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06762_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008217", "original_object": "MESH:D006973"}
{"subject": "CHEBI:4514", "predicate": "biolink:subclass_of", "object": "CHEBI:32952", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:4514", "original_object": "CHEBI:32952"}
{"subject": "MONDO:0017791", "predicate": "biolink:associated_with", "object": "MONDO:0002933", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0017791", "original_object": "HP:0011001"}
{"subject": "MESH:D062065", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005093", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:18005315"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D062065", "original_object": "MESH:D012871"}
{"subject": "GO:0043704", "predicate": "biolink:related_to", "object": "CL:0000210", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0043704", "original_object": "CL:0000210"}
{"subject": "GO:0019627", "predicate": "biolink:has_participant", "object": "CHEBI:16199", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019627", "original_object": "CHEBI:16199"}
{"subject": "CL:0003012", "predicate": "biolink:overlaps", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0003012", "original_object": "NCBITaxon:6072"}
{"subject": "CHEBI:17234", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005148", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00284_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17234", "original_object": "MESH:D003924"}
{"subject": "MONDO:0005224", "predicate": "biolink:affects", "object": "UMLS:C1514037", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C3249", "original_object": "NCIT:C37179"}
{"object": "MONDO:0019087", "predicate": "biolink:causes", "subject": "UBERON:0002394", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0019087", "original_subject": "UBERON:0002394"}
{"subject": "UBERON:0001460", "predicate": "biolink:coexists_with", "object": "UBERON:0001467", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001460", "original_object": "UBERON:0001467"}
{"subject": "HP:0012844", "predicate": "biolink:has_phenotype", "object": "MONDO:0007758", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C4113", "original_object": "NCIT:C35541"}
{"subject": "GO:0060638", "predicate": "biolink:occurs_in", "object": "CL:0008019", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060638", "original_object": "CL:0008019"}
{"subject": "GO:0140619", "predicate": "biolink:regulates", "object": "GO:0000150", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0140619", "original_object": "GO:0000150", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "GO:0048731", "predicate": "biolink:has_output", "object": "UBERON:0000467", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0048731", "original_object": "UBERON:0000467"}
{"subject": "CHEBI:63556", "predicate": "biolink:has_part", "object": "CHEBI:53621", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:63556", "original_object": "CHEBI:53621"}
{"subject": "CHEBI:89510", "predicate": "biolink:correlated_with", "object": "NCBIGene:2688", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:8729530", "PMID:9640412", "PMID:16384844"], "original_subject": "HMDB:HMDB0000569", "original_object": "OMIM:139250"}
{"subject": "CHEBI:17015", "predicate": "biolink:similar_to", "object": "CHEBI:16238", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00140", "original_object": "DRUGBANK:DB03147"}
{"subject": "GO:0036398", "predicate": "biolink:overlaps", "object": "GO:0005886", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0036398", "original_object": "GO:0005886"}
{"subject": "UBERON:6001649", "predicate": "biolink:contributes_to", "object": "UBERON:0003142", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "FBbt:00001649", "original_object": "UBERON:0003142"}
{"subject": "NCBIGene:6863", "predicate": "biolink:negatively_correlated_with", "object": "GO:0098818", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00454_MESH_D010146_1", "DB00454_MESH_D048949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P20366", "original_object": "GO:0098818"}
{"subject": "GO:0006270", "predicate": "biolink:precedes", "object": "REACT:R-PFA-68962", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006270", "original_object": "REACT:R-PFA-68962"}
{"subject": "CHEBI:17688", "predicate": "biolink:affects", "object": "MONDO:0005002", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:30576219"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D009538", "original_object": "MESH:D029424"}
{"subject": "CHEBI:36080", "predicate": "biolink:subclass_of", "object": "PR:000000001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:36080", "original_object": "PR:000000001"}
{"subject": "CHEBI:3385", "predicate": "biolink:affects", "object": "HGNC.FAMILY:180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00411_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D002217", "original_object": "HGNC.FAMILY:180"}
{"subject": "NCBIGene:6910", "predicate": "biolink:acts_upstream_of", "object": "GO:1901846", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:15289437"], "original_subject": "UniProtKB:Q99593", "original_object": "GO:1901846"}
{"subject": "MONDO:0001501", "predicate": "biolink:affects", "object": "UBERON:0003693", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C4832", "original_object": "NCIT:C12298"}
{"subject": "GO:0120111", "predicate": "biolink:related_to", "object": "GO:0019226", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0120111", "original_object": "GO:0019226"}
{"subject": "GO:0005983", "predicate": "biolink:affects", "object": "CHEBI:17234", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00284_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0005983", "original_object": "CHEBI:17234"}
{"subject": "NCBIGene:401024", "predicate": "biolink:acts_upstream_of_or_within_positive_effect", "object": "GO:0007288", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:30137358", "PMID:30745215"], "original_subject": "UniProtKB:Q5CZC0", "original_object": "GO:0007288"}
{"subject": "MONDO:0001898", "predicate": "biolink:affects", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000610", "original_object": "NCBITaxon:6072"}
{"subject": "NCBIGene:3569", "predicate": "biolink:affects_sensitivity_to", "object": "MESH:C098607", "primary_knowledge_source": "infores:ctd", "description": "affects response to", "taxon": "NCBITaxon:10090", "publications": ["PMID:22966985"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:3569", "original_object": "MESH:C098607"}
{"subject": "NCBIGene:1571", "predicate": "biolink:increases_sensitivity_to", "object": "MESH:D022882", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "NCBITaxon:9606", "publications": ["PMID:15289170"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:1571", "original_object": "MESH:D022882"}
{"subject": "NCBIGene:7453", "predicate": "biolink:affects", "object": "CHEBI:29888", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P23381", "original_object": "HMDB:HMDB0000250", "object_aspect_qualifier": "abundance"}
{"subject": "UBERON:2007045", "predicate": "biolink:develops_from", "object": "UBERON:0009615", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:2007045", "original_object": "UBERON:0009615"}
{"subject": "GO:0022016", "predicate": "biolink:occurs_in", "object": "UBERON:0000955", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0022016", "original_object": "UBERON:0000955"}
{"subject": "GO:0071897", "predicate": "biolink:correlated_with", "object": "GO:0008283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00791_MESH_D008228_1", "DB00791_MESH_D011087_1", "DB00791_MESH_D015451_1", "DB00791_MESH_D015464_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071897", "original_object": "GO:0008283"}
{"subject": "GO:0034188", "predicate": "biolink:precedes", "object": "GO:0009987", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0034188", "original_object": "GO:0009987"}
{"subject": "CL:0000091", "predicate": "biolink:located_in", "object": "UBERON:0000949", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000091", "original_object": "UBERON:0000949"}
{"object": "CHEBI:17627", "predicate": "biolink:has_participant", "subject": "SMPDB:SMP0000220", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HMDB:HMDB0003178", "original_subject": "SMPDB:SMP0000220"}
{"subject": "CHEBI:76358", "predicate": "biolink:has_part", "object": "CHEBI:76358", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:76359", "original_object": "CHEBI:76358"}
{"subject": "NCBIGene:4094", "predicate": "biolink:located_in", "object": "CL:0002038", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:O75444", "original_object": "CL:0002038"}
{"subject": "GO:0015720", "predicate": "biolink:has_input", "object": "CHEBI:15676", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015720", "original_object": "CHEBI:15676"}
{"object": "GO:0030876", "predicate": "biolink:has_participant", "subject": "GO:0071345", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0030876", "original_subject": "GO:0071345"}
{"subject": "NCBIGene:254531", "predicate": "biolink:regulates", "object": "CHEBI:15346", "primary_knowledge_source": "infores:metabolomics_workbench", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "HGNC:30059", "original_object": "PUBCHEM.COMPOUND:87642"}
{"subject": "GO:0070434", "predicate": "biolink:regulates", "object": "GO:0070431", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0070434", "original_object": "GO:0070431", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "CHEBI:16526", "predicate": "biolink:correlated_with", "object": "HP:0001950", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00819_MESH_D000532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002245", "original_object": "HP:0001950"}
{"subject": "MESH:D022882", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0005059", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:16319293"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D022882", "original_object": "MESH:D007938"}
{"subject": "CHEBI:33744", "predicate": "biolink:has_part", "object": "CHEBI:33356", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:33744", "original_object": "CHEBI:33356"}
{"subject": "CHEBI:33853", "predicate": "biolink:positively_correlated_with", "object": "EFO:0004344", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:18709157", "PMID:21900077", "PMID:25061923"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010636", "original_object": "MESH:D001724"}
{"subject": "CL:0000921", "predicate": "biolink:related_to", "object": "CHEBI:24402", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000921", "original_object": "CHEBI:24402"}
{"subject": "NCBIGene:6580", "predicate": "biolink:located_in", "object": "UBERON:0008404", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:O15245", "original_object": "UBERON:0008404"}
{"subject": "CHEBI:59057", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:42567", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:6634", "original_object": "PUBCHEM.COMPOUND:5281614"}
{"subject": "CL:0000771", "predicate": "biolink:related_to", "object": "GO:0004930", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000771", "original_object": "GO:0004930"}
{"subject": "NCBIGene:5743", "predicate": "biolink:target_for", "object": "HP:0002315", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09213_MESH_D006261_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P35354", "original_object": "MESH:D006261"}
{"subject": "CHEBI:132833", "predicate": "biolink:subclass_of", "object": "CHEBI:60911", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:132833", "original_object": "CHEBI:60911"}
{"subject": "MONDO:0019189", "predicate": "biolink:disrupts", "object": "GO:0006082", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0019189", "original_object": "GO:0006082"}
{"subject": "CHEBI:75736", "predicate": "biolink:subclass_of", "object": "CHEBI:60004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:75736", "original_object": "CHEBI:60004"}
{"subject": "CHEBI:7494", "predicate": "biolink:causes", "object": "UMLS:C1142135", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01149", "original_object": "UMLS:C1142135"}
{"object": "GO:0002443", "predicate": "biolink:causes", "subject": "CL:0000738", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0002443", "original_subject": "CL:0000738"}
{"subject": "GO:0071036", "predicate": "biolink:overlaps", "object": "GO:0010467", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071036", "original_object": "GO:0010467"}
{"subject": "CHEBI:31644", "predicate": "biolink:causes", "object": "UMLS:C0277925", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00538", "original_object": "UMLS:C0277925"}
{"subject": "GO:0086016", "predicate": "biolink:occurs_in", "object": "UBERON:0002085", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0086016", "original_object": "UBERON:0002085"}
{"subject": "REACT:R-HSA-9629591", "predicate": "biolink:has_output", "object": "CHEBI:30031", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-9629591", "original_object": "CHEBI:30031"}
{"subject": "NCBIGene:150", "predicate": "biolink:correlated_with", "object": "MONDO:0002009", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06148_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08913", "original_object": "MESH:D003865"}
{"subject": "UNII:DJX4AL4ENX", "predicate": "biolink:positively_correlated_with", "object": "GO:0035861", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01262_MESH_D015470_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PUBCHEM.COMPOUND:126357", "original_object": "GO:0035861"}
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{"subject": "HP:0012514", "predicate": "biolink:correlated_with", "object": "MONDO:0005391", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08872_MESH_D012148_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012514", "original_object": "MESH:D012148"}
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{"subject": "GO:0006281", "predicate": "biolink:occurs_in", "object": "MONDO:0005060", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05109_MESH_D008080_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006281", "original_object": "MESH:D008080"}
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{"subject": "REACT:R-SSC-110357", "predicate": "biolink:precedes", "object": "GO:0045008", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SSC-110357", "original_object": "GO:0045008"}
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{"subject": "GO:1990264", "predicate": "biolink:precedes", "object": "GO:0004672", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990264", "original_object": "GO:0004672"}
{"subject": "HP:0012531", "predicate": "biolink:contributes_to", "object": "HP:0003326", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00788_MESH_D063806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012531", "original_object": "MESH:D063806"}
{"subject": "GO:0010255", "predicate": "biolink:occurs_in", "object": "CL:0000000", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0010255", "original_object": "CL:0000000"}
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{"subject": "UBERON:0010427", "predicate": "biolink:affects", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01210_MESH_D009798_3", "DB01210_MESH_D009798_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "synthesis", "original_subject": "UBERON:0010427", "original_object": "UBERON:0001796"}
{"subject": "GO:0086063", "predicate": "biolink:occurs_in", "object": "UBERON:0002302", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0086063", "original_object": "UBERON:0002302"}
{"subject": "GO:0007188", "predicate": "biolink:has_part", "object": "GO:0004016", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007188", "original_object": "GO:0004016"}
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{"subject": "UBERON:0010210", "predicate": "biolink:occurs_in", "object": "MONDO:0005279", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09075_MESH_D011655_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010210", "original_object": "MESH:D011655"}
{"subject": "HP:0005247", "predicate": "biolink:affects", "object": "UBERON:0018254", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0005247", "original_object": "UBERON:0018254"}
{"subject": "GO:0002144", "predicate": "biolink:related_to", "object": "CHEBI:17843", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0002144", "original_object": "CHEBI:17843"}
{"subject": "HP:0007922", "predicate": "biolink:affects", "object": "GO:0042552", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0007922", "original_object": "GO:0042552"}
{"subject": "UBERON:6016022", "predicate": "biolink:contributes_to", "object": "NCBITaxon:7227", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "FBbt:00016022", "original_object": "NCBITaxon:7227"}
{"subject": "GO:0070294", "predicate": "biolink:correlated_with", "object": "HP:0000969", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D065446_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0070294", "original_object": "HP:0000969"}
{"subject": "CHEBI:17747", "predicate": "biolink:positively_correlated_with", "object": "MESH:D058226", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:21621210"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D004051", "original_object": "MESH:D058226"}
{"subject": "NCBIGene:4582", "predicate": "biolink:affects_sensitivity_to", "object": "UNII:99QP4ELX96", "primary_knowledge_source": "infores:ctd", "description": "affects response to", "taxon": "NCBITaxon:9606", "publications": ["PMID:25053108"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:4582", "original_object": "MESH:C119536"}
{"object": "NCBIGene:6348", "predicate": "biolink:gene_product_of", "subject": "GTOPDB:756", "primary_knowledge_source": "infores:gtopdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:11170631", "PMID:12381680", "PMID:16298345", "PMID:8530354", "PMID:9624164", "PMID:9790730"], "original_object": "HGNC:10627", "original_subject": "GTOPDB:756"}
{"subject": "CHEBI:35825", "predicate": "biolink:related_to", "object": "CHEBI:15366", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:35825", "original_object": "CHEBI:15366"}
{"subject": "CHEBI:88061", "predicate": "biolink:related_to", "object": "NCBIGene:3727", "primary_knowledge_source": "infores:ctd", "description": "increases stability of", "taxon": "NCBITaxon:10116", "publications": ["PMID:20805360"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011073", "original_object": "NCBIGENE:3727"}
{"subject": "GO:1905059", "predicate": "biolink:in_taxon", "object": "NCBITaxon:131567", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1905059", "original_object": "NCBITaxon:131567"}
{"subject": "CHEBI:15355", "predicate": "biolink:regulates", "object": "GO:0014832", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01400_MESH_D016055_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D000109", "original_object": "GO:0014832"}
{"subject": "UMLS:C0017797", "predicate": "biolink:similar_to", "object": "CHEBI:17196", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00130", "original_object": "DRUGBANK:DB00174"}
{"object": "GO:0005899", "predicate": "biolink:has_participant", "subject": "GO:0008286", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0005899", "original_subject": "GO:0008286"}
{"subject": "GO:0072597", "predicate": "biolink:occurs_in", "object": "GO:0009507", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0072597", "original_object": "GO:0009507"}
{"subject": "UMLS:C0003999", "predicate": "biolink:similar_to", "object": "CHEBI:132233", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00168", "original_object": "DRUGBANK:DB00182"}
{"subject": "HP:0008972", "predicate": "biolink:affects", "object": "GO:0098803", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0008972", "original_object": "GO:0098803"}
{"object": "GO:0097209", "predicate": "biolink:has_part", "subject": "CL:0000312", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0097209", "original_subject": "CL:0000312"}
{"subject": "GO:0006954", "predicate": "biolink:regulates", "object": "HP:0002829", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00005_MESH_D001171_1", "DB00005_MESH_D001172_1", "DB00005_MESH_D015535_1", "DB00605_MESH_D001172_1", "DB01401_MESH_D001172_1", "DB01401_MESH_D010003_1", "DB06674_MESH_D001172_1", "DB08904_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0006954", "original_object": "HP:0002829"}
{"subject": "UBERON:0012352", "predicate": "biolink:composed_primarily_of", "object": "GO:0031012", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0012352", "original_object": "GO:0031012"}
{"object": "MESH:D054680", "predicate": "biolink:located_in", "subject": "GO:0006412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01172_MESH_D002761_1", "DB01172_MESH_D008581_1", "DB01172_MESH_D014552_1", "DB01172_MESH_D018410_1", "DB01172_MESH_D059413_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:D054680", "original_subject": "GO:0006412"}
{"subject": "CHEBI:87184", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:18059", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03808_MESH_D015823_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C018961", "original_object": "CHEBI:18059"}
{"subject": "NCBIGene:4846", "predicate": "biolink:increases_sensitivity_to", "object": "MESH:D010936", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "NCBITaxon:9606", "publications": ["PMID:22563892"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:4846", "original_object": "MESH:D010936"}
{"subject": "GO:0030518", "predicate": "biolink:positively_correlated_with", "object": "GO:0071391", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06710_MESH_D011628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030518", "original_object": "GO:0071391"}
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{"subject": "MONDO:0016373", "predicate": "biolink:has_part", "object": "HP:0002411", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000317", "original_object": "HP:0002411"}
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{"subject": "CHEBI:15355", "predicate": "biolink:positively_correlated_with", "object": "HP:0000616", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01057_MESH_D000080362_1", "DB01057_MESH_D005901_1", "DB01057_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000109", "original_object": "HP:0000616"}
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{"subject": "UNII:I0BGE6P6I6", "predicate": "biolink:treats", "object": "MONDO:0100096", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5501", "original_object": "UMLS:C5203670"}
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{"subject": "GO:0042600", "predicate": "biolink:related_to", "object": "UBERON:0000087", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003124", "original_object": "UBERON:0000087"}
{"subject": "CHEBI:50749", "predicate": "biolink:has_part", "object": "CHEBI:50749", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:90861", "original_object": "CHEBI:50749"}
{"subject": "MONDO:0002267", "predicate": "biolink:positively_correlated_with", "object": "HP:0012735", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11359_MESH_D003139_1", "DB11359_MESH_D003371_1", "DB11359_MESH_D012220_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0006536", "original_object": "HP:0012735"}
{"subject": "CHEBI:18243", "predicate": "biolink:located_in", "object": "UBERON:0001910", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00850_MESH_D012559_1", "DB01224_MESH_D012559_1", "DB04842_MESH_D012559_1", "DB08922_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:18243", "original_object": "UBERON:0001910"}
{"subject": "NCBIGene:2176", "predicate": "biolink:increases_sensitivity_to", "object": "UMLS:C0025241", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "NCBITaxon:9606", "publications": ["PMID:16243825"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:2176", "original_object": "MESH:D008558"}
{"subject": "MONDO:0005311", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "UMLS:C0020197", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9227583", "PMC:9227583"], "tmkp_confidence_score": 0.657340224460825, "sentences": "Herein, we constructed an enzyme-responsive and macrophage-targeting drug delivery system (SIM@HA-MSN) which can potentially modulate the microenvironment of the atherosclerotic plaques characterized by excessive inflammation and overexpression of hyaluronidase (HAase) for precise AS treatment.|NA|Herein, we constructed an enzyme-responsive and macrophage-targeting drug delivery system (SIM@HA-MSN) which can potentially modulate the microenvironment of the atherosclerotic plaques characterized by excessive inflammation and overexpression of hyaluronidase (HAase) for precise AS treatment.|NA", "tmkp_ids": ["tmkp:f2dc22edcee0944b909bc81fd441c68bce625437b524fb0e728764b5a9be667b", "tmkp:a26f36302fc9df705ce094b31aff04797c0a4783d1fc2d9f59adaef72ec92c75"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "MONDO:0005311", "original_object": "DRUGBANK:DB14740"}
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{"subject": "CHEBI:18358", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00553_MESH_D016410_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008730", "original_object": "MESH:D004247"}
{"subject": "CHEBI:25029", "predicate": "biolink:positively_correlated_with", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:25029", "original_object": "GO:0006954"}
{"subject": "NCBIGene:11180", "predicate": "biolink:acts_upstream_of_negative_effect", "object": "GO:0070314", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:17216128"], "original_subject": "UniProtKB:Q9NNW5", "original_object": "GO:0070314"}
{"subject": "HP:0012531", "predicate": "biolink:manifestation_of", "object": "HP:0003418", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01744_MESH_D001416_1", "DB06774_MESH_D001416_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012531", "original_object": "MESH:D001416"}
{"subject": "GO:0009051", "predicate": "biolink:temporally_related_to", "object": "GO:0004616", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009051", "original_object": "GO:0004616"}
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{"subject": "CHEBI:32016", "predicate": "biolink:contraindicated_in", "object": "CHEBI:5138", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4224", "original_object": "UMLS:C0085228"}
{"subject": "CHEBI:132146", "predicate": "biolink:subclass_of", "object": "PR:000000001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:132146", "original_object": "PR:000000001"}
{"subject": "MONDO:0037748", "predicate": "biolink:affects", "object": "CHEBI:50404", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0010980", "original_object": "CHEBI:50404"}
{"subject": "CHEBI:61599", "predicate": "biolink:related_to", "object": "CHEBI:139252", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:61599", "original_object": "CHEBI:139252"}
{"subject": "UBERON:0000479", "predicate": "biolink:has_part", "object": "GO:0031012", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000479", "original_object": "GO:0031012"}
{"subject": "UBERON:8600026", "predicate": "biolink:composed_primarily_of", "object": "UBERON:0007106", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:8600026", "original_object": "UBERON:0007106"}
{"subject": "CHEBI:15430", "predicate": "biolink:correlated_with", "object": "MONDO:0008319", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:13765301"], "original_subject": "HMDB:HMDB0000241", "original_object": "OMIM:177000"}
{"subject": "GO:0042311", "predicate": "biolink:contributes_to", "object": "HP:0010783", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13158_MESH_D003876_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042311", "original_object": "HP:0010783"}
{"subject": "MONDO:0012339", "predicate": "biolink:contributes_to", "object": "MONDO:0012339", "primary_knowledge_source": "infores:omim", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "not_provided", "agent_type": "not_provided", "id": "uuid:9fe1eacd-3039-4c35-94ce-f17e49286218", "category": ["biolink:CorrelatedGeneToDiseaseAssociation", "biolink:EntityToDiseaseAssociationMixin", "biolink:GeneToEntityAssociationMixin", "biolink:Association", "biolink:Entity", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin"], "file_source": "omim_gene_to_disease_edges", "provided_by": "omim_gene_to_disease_edges", "original_subject": "MONDO:0012339", "original_object": "MONDO:0012339", "grouping_key": "MONDO:0012339||biolink:contributes_to|MONDO:0012339"}
{"subject": "UNII:5BSH2G9BH8", "predicate": "biolink:chemically_similar_to", "object": "NCBIGene:6439", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04897_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C502722", "original_object": "UniProtKB:P07988"}
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{"subject": "GO:0036480", "predicate": "biolink:occurs_in", "object": "UBERON:0001016", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0036480", "original_object": "UBERON:0001016"}
{"subject": "CHEBI:30956", "predicate": "biolink:affects", "object": "EFO:0004344", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:22225821"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D014238", "original_object": "MESH:D001724"}
{"subject": "MONDO:0006496", "predicate": "biolink:occurs_in", "object": "NCBITaxon:6181", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01058_MESH_D012552_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0003470", "original_object": "NCBITaxon:6181"}
{"subject": "UniProtKB:Q05486", "predicate": "biolink:capable_of", "object": "GO:0003964", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01265_MESH_D019694_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q05486", "original_object": "GO:0003964"}
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{"subject": "GO:0007259", "predicate": "biolink:regulates", "object": "GO:0019221", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08877_MESH_D009196_1", "DB08877_MESH_D011087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0007259", "original_object": "GO:0019221"}
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{"subject": "CHEBI:18308", "predicate": "biolink:affects", "object": "UMLS:C0021508", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:17938725"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:C036658", "original_object": "MESH:D007280"}
{"subject": "MESH:D054681", "predicate": "biolink:target_for", "object": "MONDO:0005316", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01190_MESH_D016585_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D054681", "original_object": "MESH:D016585"}
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{"subject": "UBERON:0005777", "predicate": "biolink:capable_of", "object": "GO:0003094", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0005777", "original_object": "GO:0003094"}
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{"subject": "HP:0030431", "predicate": "biolink:related_to", "object": "NCIT:C35959", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C3295", "original_object": "NCIT:C35959"}
{"subject": "GO:0005528", "predicate": "biolink:regulates", "object": "GO:0005955", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00864_MESH_D003876_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0005528", "original_object": "GO:0005955"}
{"subject": "HP:0030685", "predicate": "biolink:affects", "object": "NCBIGene:9370", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0030685", "original_object": "PR:Q15848"}
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{"subject": "MONDO:0021156", "predicate": "biolink:subclass_of", "object": "UBERON:0001062", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C12399", "original_object": "NCIT:C12219"}
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{"subject": "GO:0001820", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:28790", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00420_MESH_D009325_1", "DB00420_MESH_D014839_1", "DB00420_MESH_D017118_1", "DB00508_MESH_D011618_5"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001820", "original_object": "MESH:D012701"}
{"subject": "GO:1990972", "predicate": "biolink:capable_of", "object": "GO:0007160", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990972", "original_object": "GO:0007160"}
{"subject": "NCBIGene:3569", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0015564", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09036_MESH_D005871_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P05231", "original_object": "MESH:D005871"}
{"subject": "UMLS:C3529561", "predicate": "biolink:chemically_similar_to", "object": "NCBIGene:2157", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09109_MESH_D006467_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C577506", "original_object": "UniProtKB:P00451"}
{"subject": "CHEBI:32297", "predicate": "biolink:regulates", "object": "HGNC.FAMILY:184", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12131_MESH_D003704_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C013983", "original_object": "HGNC.FAMILY:184"}
{"subject": "CHEBI:16991", "predicate": "biolink:occurs_in", "object": "CL:0000084", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01204_MESH_D020529_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004247", "original_object": "CL:0000084"}
{"subject": "CHEBI:16977", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0022650", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4255", "original_object": "UMLS:C0022650"}
{"object": "MONDO:0800386", "predicate": "biolink:causes", "subject": "CHEBI:25703", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0800386", "original_subject": "CHEBI:25703"}
{"subject": "GO:0005246", "predicate": "biolink:causes", "object": "GO:0070588", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005246", "original_object": "GO:0070588"}
{"subject": "CHEBI:16576", "predicate": "biolink:located_in", "object": "GO:0009275", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00512_MESH_D000071074_1", "DB00512_MESH_D004697_1", "DB00512_MESH_D004761_1", "DB00512_MESH_D011023_1", "DB00512_MESH_D013203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16576", "original_object": "GO:0009275"}
{"subject": "GO:0038131", "predicate": "biolink:has_participant", "object": "PR:000000001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0038131", "original_object": "PR:000000001"}
{"subject": "HP:0007906", "predicate": "biolink:contributes_to", "object": "MONDO:0005041", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13165_MESH_D005901_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0007906", "original_object": "MESH:D005901"}
{"subject": "CHEBI:63681", "predicate": "biolink:affects", "object": "GO:0005840", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00358_MESH_D016780_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D015767", "original_object": "GO:0005840"}
{"subject": "NCBIGene:3764", "predicate": "biolink:positively_correlated_with", "object": "GO:0015272", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01289_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q15842", "original_object": "GO:0015272"}
{"subject": "GO:0006694", "predicate": "biolink:affects", "object": "MESH:D000305", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01284_MESH_D000309_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0006694", "original_object": "MESH:D000305"}
{"subject": "GO:0021776", "predicate": "biolink:occurs_in", "object": "UBERON:0001137", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0021776", "original_object": "UBERON:0001137"}
{"subject": "CHEBI:88316", "predicate": "biolink:has_part", "object": "CHEBI:88323", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:88316", "original_object": "CHEBI:88323"}
{"subject": "HP:0008445", "predicate": "biolink:affects", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0008445", "original_object": "NCBITaxon:6072"}
{"subject": "MONDO:0006282", "predicate": "biolink:has_participant", "object": "CL:0002138", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0006282", "original_object": "CL:0002138"}
{"subject": "GO:0005618", "predicate": "biolink:occurs_in", "object": "NCBITaxon:485", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01602_MESH_D006069_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005618", "original_object": "NCBITaxon:485"}
{"subject": "CHEBI:63580", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR10367", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00811_MESH_D018357_1", "DB00811_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D012254", "original_object": "PANTHER.FAMILY:PTHR10367"}
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{"subject": "REACT:R-HSA-1169410", "predicate": "biolink:disrupts", "object": "NCBITaxon:10407", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00105_MESH_D019694_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-1169410", "original_object": "NCBITaxon:10407"}
{"subject": "GO:0006412", "predicate": "biolink:affects", "object": "UniProtKB:A9UF02", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04865_MESH_D015464_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0006412", "original_object": "UniProtKB:A9UF02"}
{"subject": "UNII:7XL5ISS668", "predicate": "biolink:coexists_with", "object": "UNII:V7I58RC5EJ", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08870_MESH_D006689_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C547738", "original_object": "MESH:C495575"}
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{"subject": "GO:0003092", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01324_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0003092", "original_object": "MESH:D006973"}
{"subject": "GO:0071391", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:50114", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04938_MESH_D004414_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071391", "original_object": "MESH:D004967"}
{"subject": "GO:0006470", "predicate": "biolink:occurs_in", "object": "UMLS:C0027108", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01020_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006470", "original_object": "UMLS:C0027108"}
{"subject": "HP:0045061", "predicate": "biolink:affects", "object": "CHEBI:17126", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0045061", "original_object": "CHEBI:17126"}
{"subject": "CHEBI:4646", "predicate": "biolink:has_metabolite", "object": "CHEBI:28918", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00449_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C015173", "original_object": "MESH:D004837"}
{"subject": "UBERON:0004684", "predicate": "biolink:related_to", "object": "CHEBI:350546", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004684", "original_object": "CHEBI:350546"}
{"subject": "HP:0005968", "predicate": "biolink:positively_correlated_with", "object": "HP:0031217", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00286_MESH_D019584_1", "DB01395_MESH_D019584_1", "DB04575_MESH_D019584_1", "DB06401_MESH_D019584_1", "DB06710_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0005968", "original_object": "MESH:D019584"}
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{"subject": "UBERON:0007633", "predicate": "biolink:located_in", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0007633", "original_object": "NCBITaxon:6072"}
{"subject": "MONDO:0001577", "predicate": "biolink:has_part", "object": "CHEBI:29105", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "complex_context": ["M2-1:Zn2+"], "original_subject": "DOID:1273", "original_object": "CHEBI:29105"}
{"subject": "GO:0018393", "predicate": "biolink:occurs_in", "object": "NCBIGene:4137", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08842_MESH_D000544_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0018393", "original_object": "UniProtKB:P10636"}
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{"subject": "CHEBI:26865", "predicate": "biolink:has_part", "object": "CHEBI:33353", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:26865", "original_object": "CHEBI:33353"}
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{"subject": "NCBIGene:11188", "predicate": "biolink:affects", "object": "UBERON:0000013", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09242_MESH_D000075222_1", "DB11738_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:Q9Y2I1", "original_object": "UBERON:0000013"}
{"subject": "NCBIGene:5153", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:176719", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01244_MESH_D000787_8"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q01064", "original_object": "MESH:D002147"}
{"subject": "MONDO:0001244", "predicate": "biolink:affects", "object": "CHEBI:28384", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0011892", "original_object": "CHEBI:28384"}
{"subject": "GO:0022028", "predicate": "biolink:related_to", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0022028", "original_object": "NCBITaxon:6072"}
{"subject": "MESH:C099150", "predicate": "biolink:regulates", "object": "GO:0007049", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05109_MESH_D007890_1", "DB05109_MESH_D008080_1", "DB05109_MESH_D010051_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C099150", "original_object": "GO:0007049"}
{"subject": "CHEBI:61452", "predicate": "biolink:related_to", "object": "CHEBI:131701", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:61452", "original_object": "CHEBI:131701"}
{"object": "UBERON:0004360", "predicate": "biolink:has_part", "subject": "MONDO:0004779", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "NCIT:C33732", "original_subject": "NCIT:C12328"}
{"subject": "CHEBI:135443", "predicate": "biolink:treats", "object": "MONDO:0004247", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2226", "original_object": "UMLS:C0030920"}
{"subject": "UBERON:0007475", "predicate": "biolink:composed_primarily_of", "object": "GO:0031012", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0007475", "original_object": "GO:0031012"}
{"subject": "NCBIGene:4968", "predicate": "biolink:affects_sensitivity_to", "object": "UMLS:C0054252", "primary_knowledge_source": "infores:ctd", "description": "affects response to", "taxon": "NCBITaxon:10090", "publications": ["PMID:32585298"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:4968", "original_object": "MESH:D019328"}
{"subject": "CHEBI:28502", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005100", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00797", "original_object": "DOID:418"}
{"subject": "CHEBI:15552", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:5739", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01240_MESH_D000081029_1", "DB01240_MESH_D003139_1", "DB01240_MESH_D003371_1", "DB01240_MESH_D006976_1", "DB01240_MESH_D012220_1", "DB01240_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011464", "original_object": "UniProtKB:P43119"}
{"object": "CL:0002453", "predicate": "biolink:has_part", "subject": "CL:0000125", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0002453", "original_subject": "CL:0000125"}
{"subject": "MESH:C078049", "predicate": "biolink:regulates", "object": "GO:0009340", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01044_MESH_D003234_1", "DB01044_MESH_D018410_1", "DB01044_MESH_D061387_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C078049", "original_object": "GO:0009340"}
{"subject": "GO:0060612", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D005230", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060612", "original_object": "MESH:D005230"}
{"subject": "CL:0000092", "predicate": "biolink:positively_correlated_with", "object": "GO:0045453", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00153_MESH_D010024_1", "DB00153_MESH_D015663_1", "DB00282_MESH_C562390_1", "DB00282_MESH_D010001_1", "DB00399_MESH_C562390_1", "DB00399_MESH_D010001_1", "DB06255_MESH_C562390_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000092", "original_object": "GO:0045453"}
{"subject": "GO:0098684", "predicate": "biolink:overlaps", "object": "UBERON:0004456", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098684", "original_object": "UBERON:0004456"}
{"subject": "NCBIGene:153", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18357", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00571_MESH_D002312_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08588", "original_object": "MESH:D009638"}
{"object": "GO:0043039", "predicate": "biolink:has_participant", "subject": "GO:0006412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13092_MESH_D000073605_1", "DB13092_MESH_D000152_1", "DB13092_MESH_D000196_1", "DB13092_MESH_D000881_1", "DB13092_MESH_D001991_1", "DB13092_MESH_D002006_1", "DB13092_MESH_D002602_1", "DB13092_MESH_D003235_1", "DB13092_MESH_D006069_1", "DB13092_MESH_D006100_1", "DB13092_MESH_D008219_1", "DB13092_MESH_D009956_1", "DB13092_MESH_D010612_1", "DB13092_MESH_D011014_1", "DB13092_MESH_D011778_1", "DB13092_MESH_D012061_1", "DB13092_MESH_D012373_1", "DB13092_MESH_D012852_1", "DB13092_MESH_D013203_1", "DB13092_MESH_D013587_1", "DB13092_MESH_D014141_1", "DB13092_MESH_D014552_1", "DB13092_MESH_D015001_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0043039", "original_subject": "GO:0006412"}
{"subject": "UBERON:0001003", "predicate": "biolink:positively_correlated_with", "object": "HP:0040189", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01243_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001003", "original_object": "HP:0040189"}
{"subject": "NCBIGene:1555", "predicate": "biolink:related_to", "object": "CHEBI:30614", "primary_knowledge_source": "infores:ctd", "description": "molecularly interacts with", "taxon": "NCBITaxon:9606", "publications": ["PMID:22521834"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:1555", "original_object": "MESH:D015123"}
{"subject": "CHEBI:17650", "predicate": "biolink:produces", "object": "CHEBI:17650", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00741_MESH_C562390_1", "DB00741_MESH_D000224_1", "DB00741_MESH_D000309_1", "DB00741_MESH_D000744_1", "DB00741_MESH_D001172_1", "DB00741_MESH_D001249_1", "DB00741_MESH_D001327_1", "DB00741_MESH_D001607_1", "DB00741_MESH_D001929_1", "DB00741_MESH_D002062_1", "DB00741_MESH_D003873_1", "DB00741_MESH_D003874_1", "DB00741_MESH_D003876_1", "DB00741_MESH_D003877_1", "DB00741_MESH_D004892_1", "DB00741_MESH_D005076_1", "DB00741_MESH_D005128_1", "DB00741_MESH_D006484_1", "DB00741_MESH_D008180_1", "DB00741_MESH_D008228_1", "DB00741_MESH_D009140_1", "DB00741_MESH_D009182_1", "DB00741_MESH_D010392_1", "DB00741_MESH_D011015_1", "DB00741_MESH_D011538_1", "DB00741_MESH_D011565_1", "DB00741_MESH_D012507_1", "DB00741_MESH_D012713_1", "DB00741_MESH_D013167_1", "DB00741_MESH_D013585_1", "DB00741_MESH_D013966_1", "DB00741_MESH_D015210_1", "DB00741_MESH_D015535_1", "DB00741_MESH_D052256_1", "DB00741_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006854", "original_object": "MESH:C007133"}
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{"subject": "UBERON:0011302", "predicate": "biolink:composed_primarily_of", "object": "CHEBI:18246", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0011302", "original_object": "CHEBI:18246"}
{"subject": "CHEBI:90936", "predicate": "biolink:related_to", "object": "CHEBI:90937", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:90936", "original_object": "CHEBI:90937"}
{"subject": "MESH:C044919", "predicate": "biolink:capable_of", "object": "GO:0046911", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08826_MESH_D017086_1", "DB08826_MESH_D019190_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C044919", "original_object": "GO:0046911"}
{"subject": "GO:0042600", "predicate": "biolink:develops_from", "object": "UBERON:0005971", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003124", "original_object": "UBERON:0005971"}
{"subject": "GO:0042600", "predicate": "biolink:coexists_with", "object": "UBERON:0000922", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003124", "original_object": "UBERON:0000922"}
{"subject": "MONDO:0002413", "predicate": "biolink:disrupts", "object": "GO:0004346", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0002413", "original_object": "GO:0004346"}
{"subject": "GO:0005152", "predicate": "biolink:precedes", "object": "GO:0019221", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005152", "original_object": "GO:0019221"}
{"subject": "REACT:R-HSA-166208", "predicate": "biolink:positively_correlated_with", "object": "HP:0031377", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00179_MESH_D055623_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-166208", "original_object": "HP:0031377"}
{"subject": "CHEBI:16933", "predicate": "biolink:regulates", "object": "GO:0009277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00681_MESH_C536777_1", "DB00681_MESH_D000152_1", "DB00681_MESH_D001228_1", "DB00681_MESH_D001759_1", "DB00681_MESH_D001991_1", "DB00681_MESH_D002177_1", "DB00681_MESH_D002179_1", "DB00681_MESH_D002180_1", "DB00681_MESH_D003047_1", "DB00681_MESH_D003235_1", "DB00681_MESH_D003453_1", "DB00681_MESH_D003963_1", "DB00681_MESH_D006660_1", "DB00681_MESH_D007896_1", "DB00681_MESH_D007898_1", "DB00681_MESH_D009091_1", "DB00681_MESH_D010612_1", "DB00681_MESH_D011014_1", "DB00681_MESH_D012852_1", "DB00681_MESH_D014552_1", "DB00681_MESH_D016921_1", "DB00681_MESH_D055744_1", "DB00681_MESH_D058387_1", "DB00681_MESH_D059413_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D004875", "original_object": "GO:0009277"}
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{"subject": "UMLS:C0282629", "predicate": "biolink:in_taxon", "object": "NCBITaxon:3052230", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09102_MESH_D019698_1", "DB09296_MESH_D019698_1", "DB11613_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0282629", "original_object": "NCBITaxon:3052230"}
{"subject": "UMLS:C0227980", "predicate": "biolink:subclass_of", "object": "MONDO:0004767", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C128598", "original_object": "NCIT:C12787"}
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{"subject": "UBERON:0003615", "predicate": "biolink:subclass_of", "object": "GO:0071953", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003615", "original_object": "UBERON:0002521"}
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{"subject": "CHEBI:4907", "predicate": "biolink:preventative_for_condition", "object": "GO:0001503", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01077_MESH_D009999_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D012968", "original_object": "GO:0001503"}
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{"subject": "CHEBI:30411", "predicate": "biolink:applied_to_treat", "object": "MONDO:0002012", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4603", "original_object": "UMLS:C0268583"}
{"subject": "CHEBI:17303", "predicate": "biolink:causes", "object": "UMLS:C0040210", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00295", "original_object": "UMLS:C0040210"}
{"subject": "NCBIGene:152", "predicate": "biolink:negatively_correlated_with", "object": "HP:0003394", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00697_MESH_D009128_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P18825", "original_object": "HP:0003394"}
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{"subject": "PANTHER.FAMILY:PTHR11935", "predicate": "biolink:regulates", "object": "GO:0008800", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00766_MESH_D004927_1", "DB00766_MESH_D007710_1", "DB00766_MESH_D011018_1", "DB00766_MESH_D011023_1", "DB00766_MESH_D012226_1", "DB00766_MESH_D013203_1", "DB00766_MESH_D014552_1", "DB00766_MESH_D018410_1", "DB09324_MESH_D002761_1", "DB09324_MESH_D004756_1", "DB09324_MESH_D004927_1", "DB09324_MESH_D012226_1", "DB09324_MESH_D059413_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "PANTHER.FAMILY:PTHR11935", "original_object": "GO:0008800"}
{"object": "NCBIGene:2110", "predicate": "biolink:has_part", "subject": "GO:0042775", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00331_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:Q16134", "original_subject": "GO:0042775"}
{"subject": "MESH:C084588", "predicate": "biolink:regulates", "object": "HGNC.FAMILY:180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00940_MESH_D014549_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C084588", "original_object": "HGNC.FAMILY:180"}
{"subject": "GO:0016209", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0006733", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00137_MESH_D015352_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0016209", "original_object": "MESH:D015352"}
{"subject": "PANTHER.FAMILY:PTHR46448", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:3791", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00398_MESH_D002292_1", "DB00398_MESH_D006528_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR46448", "original_object": "UniProtKB:P35968"}
{"subject": "CHEBI:15627", "predicate": "biolink:regulates", "object": "HP:4000007", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13036_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D013928", "original_object": "HP:4000007"}
{"subject": "HGNC.FAMILY:184", "predicate": "biolink:target_for", "object": "HP:0002487", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08992_MESH_D013035_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:184", "original_object": "MESH:D013035"}
{"subject": "MESH:D004391", "predicate": "biolink:affects", "object": "MONDO:0005252", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:25667096"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D004391", "original_object": "MESH:D006333"}
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{"subject": "UBERON:0001866", "predicate": "biolink:treats", "object": "MONDO:0011438", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00655_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D012629", "original_object": "MESH:D000152"}
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{"subject": "GO:0015272", "predicate": "biolink:negatively_correlated_with", "object": "GO:0051899", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01120_MESH_D003924_1", "DB01124_MESH_D003924_1", "DB01289_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015272", "original_object": "GO:0051899"}
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{"subject": "CL:1000274", "predicate": "biolink:contributes_to", "object": "UBERON:0004716", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:1000274", "original_object": "UBERON:0004716"}
{"subject": "NCBIGene:1800", "predicate": "biolink:disrupts", "object": "CHEBI:51799", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01597_MESH_D004697_1", "DB01597_MESH_D004716_1", "DB01597_MESH_D011018_1", "DB01597_MESH_D018410_1", "DB01597_MESH_D018784_1", "DB01597_MESH_D059413_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P16444", "original_object": "MESH:D015378"}
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{"subject": "NCBIGene:8065", "predicate": "biolink:acts_upstream_of_negative_effect", "object": "GO:0038026", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:Q93034", "original_object": "GO:0038026"}
{"subject": "HGNC.FAMILY:171", "predicate": "biolink:positively_correlated_with", "object": "GO:0051932", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01049_MESH_D003704_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:171", "original_object": "GO:0051932"}
{"subject": "GO:0042310", "predicate": "biolink:has_phenotype", "object": "MONDO:0005044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08932_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042310", "original_object": "HP:0000822"}
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{"subject": "REACT:R-HSA-418594", "predicate": "biolink:negatively_correlated_with", "object": "GO:0061533", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00454_MESH_D010146_1", "DB00454_MESH_D048949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-418594", "original_object": "GO:0061533"}
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{"subject": "CHEBI:31206", "predicate": "biolink:interacts_with", "object": "UBERON:0000410", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06767_MESH_D003139_1", "DB06767_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000643", "original_object": "UBERON:0000410"}
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{"subject": "CHEBI:84677", "predicate": "biolink:related_to", "object": "CHEBI:16394", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:84677", "original_object": "CHEBI:16394"}
{"subject": "CL:0002301", "predicate": "biolink:produces", "object": "UBERON:0001090", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0002301", "original_object": "UBERON:0001090"}
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{"subject": "HGNC.FAMILY:1927", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06723_MESH_D004381_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:1927", "original_object": "MESH:D004381"}
{"subject": "GO:0061762", "predicate": "biolink:has_input", "object": "CHEBI:29108", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0061762", "original_object": "CHEBI:29108"}
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{"subject": "GO:0042983", "predicate": "biolink:has_output", "object": "PR:000004168", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042983", "original_object": "PR:000004168"}
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{"subject": "GO:0004679", "predicate": "biolink:affects", "object": "NCBIGene:6517", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00331_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0004679", "original_object": "UniProtKB:P14672"}
{"subject": "UBERON:0002625", "predicate": "biolink:related_to", "object": "CHEBI:72587", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002625", "original_object": "CHEBI:72587"}
{"subject": "CHEBI:17855", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:47774", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08949_MESH_D006937_1", "DB08949_MESH_D006950_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014280", "original_object": "MESH:D008078"}
{"subject": "HP:4000055", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "CHEBI:3962", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:8612690"], "tmkp_confidence_score": 0.9986552, "sentences": "SP@Curcumin-mediated anti-inflammatory effects against intestinal inflammation.|NA", "tmkp_ids": ["tmkp:24b2f501a43123812c5808783ca6e292afe5e41b9dc16aaf14252e24238b51b6"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "HP:4000055", "original_object": "DRUGBANK:DB11672"}
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{"subject": "MONDO:0004934", "predicate": "biolink:subclass_of", "object": "UBERON:0002384", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C13184", "original_object": "NCIT:C12374"}
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{"subject": "CHEBI:3638", "predicate": "biolink:negatively_correlated_with", "object": "NCBIGene:54106", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00608_MESH_D001172_1", "DB00608_MESH_D008179_1", "DB00608_MESH_D008180_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002738", "original_object": "UniProtKB:Q9NR96"}
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{"subject": "UBERON:0001870", "predicate": "biolink:contributes_to", "object": "GO:0051823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D001714_2", "DB00313_MESH_D001714_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001870", "original_object": "GO:0051823"}
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{"subject": "GO:0071993", "predicate": "biolink:has_input", "object": "CHEBI:131728", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071993", "original_object": "CHEBI:131728"}
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{"subject": "CHEBI:72999", "predicate": "biolink:capable_of", "object": "GO:0043129", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09114_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C081581", "original_object": "GO:0043129"}
{"subject": "NCBIGene:1815", "predicate": "biolink:related_to", "object": "CHEBI:18243", "primary_knowledge_source": "infores:ctd", "description": "molecularly interacts with", "taxon": "NCBITaxon:10116", "publications": ["PMID:15716360"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:1815", "original_object": "MESH:D004298"}
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{"subject": "HP:0010617", "predicate": "biolink:related_to", "object": "UMLS:C0225317", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C6947", "original_object": "NCIT:C12471"}
{"subject": "GO:1990231", "predicate": "biolink:capable_of", "object": "GO:0060337", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990231", "original_object": "GO:0060337"}
{"subject": "NCBITaxon:1313", "predicate": "biolink:occurs_in", "object": "MONDO:0004652", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01211_MESH_D018410_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1313", "original_object": "MESH:D018410"}
{"subject": "GO:0030073", "predicate": "biolink:regulates", "object": "MESH:D001786", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01382_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0030073", "original_object": "MESH:D001786"}
{"subject": "CHEBI:3127", "predicate": "biolink:affects", "object": "UBERON:0034729", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00612_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D017298", "original_object": "UBERON:0034729"}
{"subject": "CHEBI:7660", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002179_1", "DB00646_MESH_D002180_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009761", "original_object": "CHEBI:16933"}
{"subject": "GO:0098991", "predicate": "biolink:overlaps", "object": "GO:0035725", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098991", "original_object": "GO:0035725"}
{"subject": "CHEBI:15422", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5661", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05630_MESH_D007896_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000255", "original_object": "NCBITaxon:5661"}
{"subject": "NCBIGene:3641571", "predicate": "biolink:produces", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01263_MESH_D009181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P10613", "original_object": "MESH:D004875"}
{"subject": "GO:0030520", "predicate": "biolink:treats", "object": "MONDO:0001196", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01708_MESH_D004414_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030520", "original_object": "MESH:D004414"}
{"subject": "NCBIGene:7442", "predicate": "biolink:regulates", "object": "CL:0000197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00405_MESH_D011537_1", "DB00434_MESH_D011537_1", "DB00557_MESH_D011537_1", "DB01084_MESH_D011537_1", "DB01114_MESH_D011537_1", "DB06691_MESH_D011537_1", "DB08799_MESH_D011537_1", "DB09555_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:Q8NER1", "original_object": "CL:0000197"}
{"subject": "GO:0016063", "predicate": "biolink:affects", "object": "NCBIGene:6010", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00162_MESH_D001361_1", "DB00162_MESH_D014802_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0016063", "original_object": "UniProtKB:P08100"}
{"subject": "CHEBI:30746", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:15428", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03793_MESH_D022124_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D019817", "original_object": "MESH:D005998"}
{"object": "GO:0004714", "predicate": "biolink:has_participant", "subject": "REACT:R-HSA-74713", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09564_MESH_D003920_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0004714", "original_subject": "REACT:R-HSA-74713"}
{"subject": "NCBIGene:1813", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01618_MESH_D012559_1", "DB11757_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P14416", "original_object": "MESH:D004298"}
{"subject": "GO:0051381", "predicate": "biolink:regulates", "object": "GO:0023041", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00341_MESH_D012912_1", "DB00434_MESH_D012912_1", "DB00434_MESH_D012912_2", "DB00637_MESH_D012912_1", "DB00950_MESH_D012912_1", "DB08799_MESH_D012912_1", "DB09488_MESH_D012912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0051381", "original_object": "GO:0023041"}
{"subject": "MESH:C048833", "predicate": "biolink:affects", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00745_MESH_D009290_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:C048833", "original_object": "MESH:D006632"}
{"subject": "GO:0000380", "predicate": "biolink:produces", "object": "UniProtKB:B4DP61", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13161_MESH_D009134_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000380", "original_object": "UniProtKB:B4DP61"}
{"subject": "NCBIGene:5578", "predicate": "biolink:contributes_to", "object": "GO:0051823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D001714_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P17252", "original_object": "GO:0051823"}
{"subject": "HGNC.FAMILY:1203", "predicate": "biolink:affects", "object": "CHEBI:26708", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01182_MESH_D001281_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "transport", "original_subject": "HGNC.FAMILY:1203", "original_object": "MESH:D012964"}
{"subject": "GO:0007189", "predicate": "biolink:affects", "object": "GO:0004691", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00374_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0007189", "original_object": "GO:0004691"}
{"subject": "CHEBI:34911", "predicate": "biolink:disrupts", "object": "UniProtKB:Q2VKV7", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04930_MESH_D012532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D026023", "original_object": "UniProtKB:Q2VKV7"}
{"subject": "CHEBI:18085", "predicate": "biolink:occurs_in", "object": "GO:0005764", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01279_MESH_D009087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006025", "original_object": "GO:0005764"}
{"subject": "UBERON:0000176", "predicate": "biolink:causes", "object": "HP:0025095", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00972_MESH_D006255_1", "DB00972_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000176", "original_object": "HP:0025095"}
{"subject": "CHEBI:5790", "predicate": "biolink:regulates", "object": "UBERON:0001896", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00327_MESH_D003139_1", "DB00327_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D004091", "original_object": "UBERON:0001896"}
{"subject": "CHEBI:21553", "predicate": "biolink:correlated_with", "object": "NCBIGene:5310", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:18215696", "PMID:21389975"], "original_subject": "HMDB:HMDB0006029", "original_object": "OMIM:601313"}
{"subject": "UBERON:0001090", "predicate": "biolink:has_part", "object": "CHEBI:16336", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001090", "original_object": "CHEBI:16336"}
{"subject": "UBERON:4000115", "predicate": "biolink:has_part", "object": "CHEBI:52255", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:4000115", "original_object": "CHEBI:52255"}
{"subject": "UBERON:0001574", "predicate": "biolink:related_to", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001574", "original_object": "NCBITaxon:6072"}
{"subject": "HP:0032263", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005068", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00335_MESH_D009203_1", "DB00722_MESH_D009203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0032263", "original_object": "MESH:D009203"}
{"subject": "CHEBI:18243", "predicate": "biolink:negatively_correlated_with", "object": "PUBCHEM.COMPOUND:16132350", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00937_MESH_D009765_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004298", "original_object": "MESH:D009478"}
{"subject": "UBERON:0005304", "predicate": "biolink:positively_correlated_with", "object": "GO:0050892", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08900_MESH_D012778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0005304", "original_object": "GO:0050892"}
{"subject": "NCBIGene:9900", "predicate": "biolink:affects", "object": "GO:0098982", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01202_MESH_D004828_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:Q7L0J3", "original_object": "GO:0098982"}
{"subject": "UBERON:0003092", "predicate": "biolink:has_part", "object": "PR:000027222", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003092", "original_object": "PR:000027222"}
{"subject": "CHEBI:39867", "predicate": "biolink:causes", "object": "UMLS:C1868980", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00313", "original_object": "UMLS:C1868980"}
{"subject": "GO:0004714", "predicate": "biolink:regulates", "object": "NCBIGene:207", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01306_MESH_D003920_1", "DB01307_MESH_D003920_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004714", "original_object": "UniProtKB:P31749"}
{"subject": "NCBIGene:9378", "predicate": "biolink:acts_upstream_of", "object": "GO:0098990", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:P58400", "original_object": "GO:0098990"}
{"subject": "UMLS:C0023775", "predicate": "biolink:disrupts", "object": "GO:0006811", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002179_1", "DB00646_MESH_D002180_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0023775", "original_object": "GO:0006811"}
{"subject": "NCBIGene:54209", "predicate": "biolink:acts_upstream_of_or_within_positive_effect", "object": "GO:0038160", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:33097708"], "original_subject": "UniProtKB:Q9NZC2", "original_object": "GO:0038160"}
{"subject": "UBERON:0001707", "predicate": "biolink:correlated_with", "object": "MONDO:0004979", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01410_MESH_D001249_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001707", "original_object": "MESH:D001249"}
{"subject": "CHEBI:63625", "predicate": "biolink:has_active_ingredient", "object": "PUBCHEM.COMPOUND:5481180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00300_MESH_D015658_1", "DB00300_MESH_D019694_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000068698", "original_object": "MESH:C583447"}
{"subject": "UBERON:0001295", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0021251", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00351_MESH_D016889_1", "DB00396_MESH_D016889_1", "DB00603_MESH_D016889_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001295", "original_object": "MESH:D016889"}
{"subject": "CHEBI:28786", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D012135", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:11874814"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010269", "original_object": "MESH:D012135"}
{"subject": "GO:0071159", "predicate": "biolink:regulates", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00434_MESH_D065631_1", "DB01114_MESH_D065631_1", "DB04837_MESH_D012220_1", "DB04837_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0071159", "original_object": "GO:0006954"}
{"subject": "UMLS:C2607955", "predicate": "biolink:causes", "object": "GO:0008219", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C2607955", "original_object": "GO:0008219"}
{"subject": "NCBIGene:154", "predicate": "biolink:regulates", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01214_MESH_D005902_1", "DB01214_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P07550", "original_object": "UBERON:0001796"}
{"subject": "CL:0000062", "predicate": "biolink:affects", "object": "UMLS:C0538161", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11093_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "expression", "original_subject": "MESH:D010006", "original_object": "MESH:D053244"}
{"subject": "CHEBI:30769", "predicate": "biolink:disrupts", "object": "UBERON:0000912", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09154_MESH_D003139_1", "DB09154_MESH_D003371_1", "DB09154_MESH_D012220_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000077559", "original_object": "UBERON:0000912"}
{"subject": "CL:0005020", "predicate": "biolink:coexists_with", "object": "UBERON:0004536", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0005020", "original_object": "UBERON:0004536"}
{"object": "MONDO:0001380", "predicate": "biolink:has_part", "subject": "UBERON:0001255", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "NCIT:C12332", "original_subject": "NCIT:C12414"}
{"subject": "CHEBI:6437", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0020039", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1563", "original_object": "UMLS:C0020039"}
{"subject": "NCBIGene:2554", "predicate": "biolink:capable_of", "object": "GO:0022851", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09166_MESH_D001008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P14867", "original_object": "GO:0022851"}
{"subject": "CHEBI:71417", "predicate": "biolink:affects", "object": "GO:0030488", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01168_MESH_D006689_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D011344", "original_object": "GO:0030488"}
{"subject": "HGNC.FAMILY:404", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR11716", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D016410_1", "DB00240_MESH_D016460_1", "DB01234_MESH_C562390_1", "DB01234_MESH_D000744_1", "DB01234_MESH_D000799_1", "DB01234_MESH_D001172_1", "DB01234_MESH_D001249_1", "DB01234_MESH_D001607_1", "DB01234_MESH_D001929_1", "DB01234_MESH_D002051_1", "DB01234_MESH_D002062_1", "DB01234_MESH_D003233_1", "DB01234_MESH_D003320_1", "DB01234_MESH_D003424_1", "DB01234_MESH_D003873_1", "DB01234_MESH_D003874_1", "DB01234_MESH_D003876_1", "DB01234_MESH_D003877_1", "DB01234_MESH_D004892_1", "DB01234_MESH_D005076_1", "DB01234_MESH_D005128_1", "DB01234_MESH_D006689_1", "DB01234_MESH_D007500_1", "DB01234_MESH_D007627_1", "DB01234_MESH_D007634_1", "DB01234_MESH_D007819_1", "DB01234_MESH_D008179_1", "DB01234_MESH_D008180_1", "DB01234_MESH_D008224_1", "DB01234_MESH_D008228_1", "DB01234_MESH_D009101_1", "DB01234_MESH_D009103_1", "DB01234_MESH_D009140_1", "DB01234_MESH_D009182_1", "DB01234_MESH_D009404_1", "DB01234_MESH_D009450_1", "DB01234_MESH_D010032_1", "DB01234_MESH_D010392_1", "DB01234_MESH_D011538_1", "DB01234_MESH_D011565_1", "DB01234_MESH_D011657_1", "DB01234_MESH_D012214_1", "DB01234_MESH_D012393_1", "DB01234_MESH_D012507_1", "DB01234_MESH_D012628_1", "DB01234_MESH_D012713_1", "DB01234_MESH_D012871_1", "DB01234_MESH_D013167_1", "DB01234_MESH_D013716_1", "DB01234_MESH_D013717_2", "DB01234_MESH_D013966_1", "DB01234_MESH_D014235_1", "DB01234_MESH_D014391_1", "DB01234_MESH_D014605_1", "DB01234_MESH_D014606_1", "DB01234_MESH_D015210_1", "DB01234_MESH_D015212_1", "DB01234_MESH_D015535_1", "DB01234_MESH_D015863_1", "DB01234_MESH_D016403_1", "DB01234_MESH_D016410_1", "DB01234_MESH_D016460_1", "DB01234_MESH_D029503_1", "DB01234_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "HGNC.FAMILY:404", "original_object": "PANTHER.FAMILY:PTHR11716"}
{"subject": "MONDO:0002012", "predicate": "biolink:causes", "object": "MONDO:0002320", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00115_MESH_D001361_1", "DB00115_MESH_D014806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002912", "original_object": "HP:0000707"}
{"subject": "GO:0071420", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00748_MESH_D003139_1", "DB00748_MESH_D003233_2", "DB00748_MESH_D006255_1", "DB00748_MESH_D011537_1", "DB00748_MESH_D012223_1", "DB00748_MESH_D014581_1", "DB00748_MESH_D065631_1", "DB01075_MESH_D003233_1", "DB01075_MESH_D006255_1", "DB01075_MESH_D012223_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071420", "original_object": "MESH:D006632"}
{"subject": "GO:0023041", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002009", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00344_MESH_D003865_1", "DB06148_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0023041", "original_object": "MESH:D003865"}
{"subject": "GO:0019233", "predicate": "biolink:occurs_in", "object": "HP:0100607", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06691_MESH_D004412_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019233", "original_object": "MESH:D004412"}
{"subject": "GO:0014046", "predicate": "biolink:located_in", "object": "UBERON:0001910", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06144_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0014046", "original_object": "UBERON:0001910"}
{"subject": "CHEBI:16113", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005098", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00175_MESH_D020521_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002784", "original_object": "MESH:D020521"}
{"subject": "UBERON:0004128", "predicate": "biolink:causes", "object": "UBERON:0004880", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004128", "original_object": "UBERON:0004880"}
{"object": "GO:0031929", "predicate": "biolink:causes", "subject": "GO:0038201", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0031929", "original_subject": "GO:0038201"}
{"subject": "CHEBI:46345", "predicate": "biolink:has_active_ingredient", "object": "PUBCHEM.COMPOUND:10255482", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09256_MESH_D013274_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005472", "original_object": "MESH:C025635"}
{"subject": "CHEBI:16113", "predicate": "biolink:located_in", "object": "UBERON:0002110", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01586_MESH_D002769_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002784", "original_object": "UBERON:0002110"}
{"subject": "MONDO:0021042", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "UNII:C4V974V932", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6304244", "PMC:8278705", "PMC:6304244", "PMC:6304244", "PMC:8278705"], "tmkp_confidence_score": 0.6542058325883658, "sentences": "In vivo SPIO@DSPE-PEG/DOX/ICG NP treatment resulted in a remarkable antitumor effect against glioma as compared with all other groups examined.|NA|To conclude, we report in the present study that ICG/PTX@RGE-EV can function as a potential drug delivery system of ICG/PTX for treatment of glioma, as evidenced by its prolonged residence period in blood circulation, and increased accumulation in tumor, thereby promoting anti-tumor action and reducing toxicity (Fig.?8).|NA|These results suggest that the SPIO@DSPE-PEG/DOX/ICG NPs can not only function as a nanoprobe for MR and fluorescence bimodal imaging, but also as a vehicle to deliver chemotherapeutic drugs to the tumor site, to achieve the theranostic treatment of glioma.|NA|To evaluate the safety, toxicity, and side effects of SPIO@DSPE-PEG/DOX/ICG NPs within glioma-bearing rats during the treatment, H&E-stained sections from the heart, liver, spleen, lung, kidney, and muscle were examined (Figure S3).|NA|The results of our study first elucidated that the inhibitory impact of ICG/PTX@RGE-EV on glioma development via apoptosis promotion, which suggested that ICG/PTX@RGE-EV might eventually be employed clinically for the treatment of glioma.|NA", "tmkp_ids": ["tmkp:367807965a370eabc32394f2c49f101f00f2290a4462d07d233d45e57481bd47", "tmkp:a08ea6fd10f89987c1fc2202d2b91f5567b79d5b7420121740116322e905cebf", "tmkp:6d141174d57a39002d1519ef17f408852aeb7667cf8bb121947f1143762508ad", "tmkp:abbd396a87c661d1f63739faf637cfde9e9627d641d19196e5a662ea04d28014", "tmkp:fe258a3fd612c261ad52efc78173d03c54f9debde90f20d8791dbd9542740d2a"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "MONDO:0021042", "original_object": "DRUGBANK:DB16024"}
{"subject": "HP:0000616", "predicate": "biolink:negatively_correlated_with", "object": "HP:0007663", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01057_MESH_D000080362_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000616", "original_object": "HP:0007663"}
{"subject": "MONDO:0003947", "predicate": "biolink:disrupts", "object": "GO:0023035", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0003947", "original_object": "GO:0023035"}
{"subject": "UBERON:0000410", "predicate": "biolink:correlated_with", "object": "GO:0070254", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06767_MESH_D003139_1", "DB06767_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000410", "original_object": "GO:0070254"}
{"subject": "UBERON:0004755", "predicate": "biolink:develops_from", "object": "CL:0007001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004755", "original_object": "CL:0007001"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0000403", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00443_MESH_D012536_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "UBERON:0000403"}
{"subject": "CHEBI:18361", "predicate": "biolink:regulates", "object": "CHEBI:52255", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05768_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:18361", "original_object": "CHEBI:52255"}
{"subject": "CHEBI:82405", "predicate": "biolink:regulates", "object": "NCBITaxon:1747", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09096_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D001585", "original_object": "NCBITaxon:1747"}
{"subject": "MONDO:0018310", "predicate": "biolink:disrupts", "object": "CL:0000453", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0018310", "original_object": "CL:0000453"}
{"subject": "GO:0002154", "predicate": "biolink:affects", "object": "NCBIGene:116519", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00451_MESH_D006949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0002154", "original_object": "UniProtKB:Q6Q788"}
{"subject": "CHEBI:65265", "predicate": "biolink:negatively_correlated_with", "object": "GO:0001696", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09481_MESH_D003248_1", "DB09481_MESH_D004415_1", "DB09481_MESH_D005764_1", "DB09481_MESH_D006356_1", "DB09481_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000863", "original_object": "GO:0001696"}
{"subject": "GO:0003943", "predicate": "biolink:affects", "object": "CHEBI:18085", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01279_MESH_D009087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0003943", "original_object": "MESH:D006025"}
{"subject": "NCBIGene:4509", "predicate": "biolink:genetically_associated_with", "object": "NCBIGene:4509", "primary_knowledge_source": "infores:uniprot", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC:7415", "original_object": "OMIM:516070"}
{"subject": "UBERON:0034929", "predicate": "biolink:overlaps", "object": "CL:0000540", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0034929", "original_object": "CL:0000540"}
{"subject": "UBERON:0001913", "predicate": "biolink:has_part", "object": "CHEBI:18059", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001913", "original_object": "CHEBI:18059"}
{"subject": "GO:0051607", "predicate": "biolink:affects", "object": "NCBITaxon:333922", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00724_MESH_D055623_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0051607", "original_object": "NCBITaxon:333922"}
{"subject": "MONDO:0005044", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005098", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00966_MESH_D020521_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006973", "original_object": "MESH:D020521"}
{"subject": "CHEBI:83379", "predicate": "biolink:has_part", "object": "CHEBI:83382", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:83379", "original_object": "CHEBI:83382"}
{"subject": "EFO:0020954", "predicate": "biolink:expressed_in", "object": "GO:0005615", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C101645", "original_object": "NCIT:C26055"}
{"subject": "UMLS:C0025241", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01042_MESH_D009101_1", "DB01042_MESH_D010051_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008558", "original_object": "MESH:D004247"}
{"subject": "CHEBI:32090", "predicate": "biolink:negatively_correlated_with", "object": "CHEBI:26519", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11656_MESH_D005756_1", "DB11656_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C052785", "original_object": "MESH:D005609"}
{"subject": "GO:0035240", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00420_MESH_D011618_1", "DB00420_MESH_D012559_1", "DB00420_MESH_D019958_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0035240", "original_object": "MESH:D004298"}
{"subject": "CHEBI:141517", "predicate": "biolink:capable_of", "object": "GO:0043129", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06439_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C016811", "original_object": "GO:0043129"}
{"subject": "CHEBI:39214", "predicate": "biolink:subclass_of", "object": "CHEBI:60004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:39214", "original_object": "CHEBI:60004"}
{"subject": "CHEBI:27786", "predicate": "biolink:affects", "object": "CHEBI:30411", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00200_MESH_D000752_1", "DB00200_MESH_D014806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D006879", "original_object": "CHEBI:30411"}
{"subject": "NCBIGene:5241", "predicate": "biolink:correlated_with", "object": "UMLS:C0042404", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P06401", "original_object": "MESH:D014666"}
{"subject": "PUBCHEM.COMPOUND:26945", "predicate": "biolink:disrupts", "object": "CL:0000232", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12975_MESH_D016778_2", "DB12975_MESH_D016780_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006427", "original_object": "CL:0000232"}
{"subject": "GO:0035805", "predicate": "biolink:coexists_with", "object": "CL:0000025", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0035805", "original_object": "CL:0000025"}
{"subject": "UBERON:0000955", "predicate": "biolink:affects", "object": "CHEBI:15514", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D008881_1", "DB00313_MESH_D008881_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "UBERON:0000955", "original_object": "MESH:C026563"}
{"subject": "GO:0038169", "predicate": "biolink:regulates", "object": "MONDO:0019933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06791_MESH_D000172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0038169", "original_object": "MESH:D000172"}
{"subject": "UBERON:0002242", "predicate": "biolink:has_part", "object": "CHEBI:18250", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002242", "original_object": "CHEBI:37397"}
{"subject": "CHEBI:28939", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06151_MESH_D001987_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000111", "original_object": "GO:0006954"}
{"subject": "UBERON:8600029", "predicate": "biolink:contributes_to", "object": "GO:0042600", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:8600029", "original_object": "UBERON:0003124"}
{"subject": "MESH:D044062", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB07615_MESH_D003876_2", "DB07615_MESH_D065631_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D044062", "original_object": "GO:0006954"}
{"subject": "NCBIGene:1240", "predicate": "biolink:in_complex_with", "object": "NCBIGene:2778", "primary_knowledge_source": "infores:signor", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:39616240"], "description": ["Altogether, our findings suggest that the CBR1 interactions between CMKLR1 and chemerin is responsible for stabilizing the chemerin-CMKLR1 complex, which allows the efficient insertion of the C-terminus of chemerin into the orthosteric binding pocket of CMKLR1 for receptor activation and downstream G protein signaling."], "species_context_qualifier": "NCBITaxon:9606", "original_subject": "UniProtKB:Q99788", "original_object": "UniProtKB:P63092"}
{"subject": "GO:0060087", "predicate": "biolink:ameliorates_condition", "object": "HP:0001681", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00335_MESH_D000787_1", "DB01020_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060087", "original_object": "MESH:D000787"}
{"object": "UBERON:0001062", "predicate": "biolink:has_part", "subject": "NCBITaxon:7227", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "FBbt:10000000", "original_subject": "NCBITaxon:7227"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "PANTHER.FAMILY:PTHR10078", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08895_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "PANTHER.FAMILY:PTHR10078"}
{"subject": "NCBIGene:4306", "predicate": "biolink:positively_correlated_with", "object": "HGNC.FAMILY:1203", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D065446_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08235", "original_object": "HGNC.FAMILY:1203"}
{"subject": "UMLS:C1517336", "predicate": "biolink:affects", "object": "NCBIGene:7015", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UMLS:C1517336", "original_object": "UniProtKB:O14746"}
{"subject": "UBERON:0012281", "predicate": "biolink:subclass_of", "object": "MONDO:0002260", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C77610", "original_object": "NCIT:C32132"}
{"subject": "HGNC.FAMILY:245", "predicate": "biolink:negatively_correlated_with", "object": "GO:0060004", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00318_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:245", "original_object": "GO:0060004"}
{"subject": "CHEBI:35441", "predicate": "biolink:ameliorates_condition", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03255_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000890", "original_object": "MESH:D011537"}
{"subject": "UMLS:C0042774", "predicate": "biolink:positively_correlated_with", "object": "UMLS:C0282629", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09102_MESH_D019698_1", "DB09296_MESH_D019698_1", "DB11613_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0042774", "original_object": "UMLS:C0282629"}
{"subject": "UBERON:0010210", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0000831", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00266_MESH_D013927_1", "DB00946_MESH_D013927_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010210", "original_object": "MESH:D013927"}
{"subject": "CL:0001074", "predicate": "biolink:has_part", "object": "NCBIGene:4684", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0001074", "original_object": "PR:P13591"}
{"subject": "CHEBI:6805", "predicate": "biolink:similar_to", "object": "CHEBI:133011", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00931", "original_object": "DRUGBANK:DB00595"}
{"subject": "NCBIGene:153", "predicate": "biolink:regulates", "object": "GO:1990454", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00264_MESH_D000787_1", "DB00264_MESH_D009203_1", "DB00264_MESH_D054058_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P08588", "original_object": "GO:1990454"}
{"subject": "MONDO:0044348", "predicate": "biolink:has_participant", "object": "CHEBI:35143", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0044348", "original_object": "CHEBI:35143"}
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{"subject": "CHEBI:18295", "predicate": "biolink:regulates", "object": "GO:0071159", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00434_MESH_D065631_1", "DB01114_MESH_D065631_1", "DB04837_MESH_D012220_1", "DB04837_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D006632", "original_object": "GO:0071159"}
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{"subject": "PUBCHEM.COMPOUND:10255482", "predicate": "biolink:disrupts", "object": "GO:0032774", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09256_MESH_D013274_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C025635", "original_object": "GO:0032774"}
{"subject": "CHEBI:32190", "predicate": "biolink:produces", "object": "CHEBI:9436", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11783_MESH_D006973_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C055603", "original_object": "MESH:C069156"}
{"subject": "GO:0007213", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:15355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00508_MESH_D011618_3", "DB00508_MESH_D011618_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007213", "original_object": "MESH:D000109"}
{"subject": "CHEBI:7959", "predicate": "biolink:capable_of", "object": "GO:0046911", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00859_MESH_D001172_2", "DB00859_MESH_D003555_2", "DB00859_MESH_D006527_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010396", "original_object": "GO:0046911"}
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{"subject": "NCBITaxon:2", "predicate": "biolink:causes", "object": "HP:0200042", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05245_MESH_D012883_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:2", "original_object": "MESH:D012883"}
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{"subject": "UBERON:0000123", "predicate": "biolink:coexists_with", "object": "GO:0043209", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000123", "original_object": "GO:0043209"}
{"subject": "GO:0016209", "predicate": "biolink:preventative_for_condition", "object": "HP:0025610", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00137_MESH_D000080343_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0016209", "original_object": "MESH:D000080343"}
{"subject": "GO:0042310", "predicate": "biolink:negatively_correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00449_MESH_D005902_1", "DB00668_MESH_D005902_1", "DB00668_MESH_D005902_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042310", "original_object": "UBERON:0001796"}
{"subject": "CHEBI:65265", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D005744", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09104_MESH_D004415_1", "DB09104_MESH_D005764_1", "DB09104_MESH_D006356_1", "DB09104_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000863", "original_object": "MESH:D005744"}
{"subject": "MONDO:0016648", "predicate": "biolink:affects", "object": "HP:0002656", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002654", "original_object": "HP:0002656"}
{"subject": "GO:0008237", "predicate": "biolink:affects", "object": "GO:0031012", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00287_MESH_D005902_1", "DB00287_MESH_D009798_1", "DB00654_MESH_D005902_1", "DB00654_MESH_D009798_1", "DB08819_MESH_D005902_1", "DB08819_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0008237", "original_object": "GO:0031012"}
{"subject": "NCBIGene:3565", "predicate": "biolink:genetically_associated_with", "object": "UMLS:C0035234", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:6014", "original_object": "UMLS:C0035234"}
{"subject": "HGNC.FAMILY:245", "predicate": "biolink:affects", "object": "CHEBI:16480", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00295_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "HGNC.FAMILY:245", "original_object": "CHEBI:16480"}
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{"subject": "CHEBI:31889", "predicate": "biolink:negatively_correlated_with", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12447_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C062127", "original_object": "UBERON:0001866"}
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{"subject": "NCBIGene:2099", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:50114", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00882_MESH_D007247_1", "DB04938_MESH_D004414_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P03372", "original_object": "MESH:D004967"}
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{"subject": "UNII:DD5RBA1NKF", "predicate": "biolink:treats", "object": "UNII:DD5RBA1NKF", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5487", "original_object": "UMLS:C2698934"}
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{"subject": "MESH:C019248", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:52255", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00282_MESH_C562390_1", "DB00282_MESH_D010001_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C019248", "original_object": "CHEBI:52255"}
{"subject": "CHEBI:28694", "predicate": "biolink:positively_correlated_with", "object": "PANTHER.FAMILY:PTHR10078", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D003300", "original_object": "PANTHER.FAMILY:PTHR10078"}
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{"subject": "NCBIGene:12035", "predicate": "biolink:subclass_of", "object": "NCBIGene:12036", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:P24288", "original_object": "PR:O35855"}
{"subject": "CL:0000198", "predicate": "biolink:contributes_to", "object": "GO:0019233", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06691_MESH_D004412_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000198", "original_object": "GO:0019233"}
{"object": "CHEBI:134745", "predicate": "biolink:derives_from", "subject": "CHEBI:41500", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08909_MESH_D056806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:C570223", "original_subject": "CHEBI:75316"}
{"subject": "UBERON:0012364", "predicate": "biolink:has_part", "object": "PR:000016283", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0012364", "original_object": "PR:000016283"}
{"subject": "GO:0006972", "predicate": "biolink:regulates", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00742_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0006972", "original_object": "UBERON:0001796"}
{"subject": "CHEBI:17256", "predicate": "biolink:disrupts", "object": "CL:0000084", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00061_MESH_C531816_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17256", "original_object": "CL:0000084"}
{"subject": "CHEBI:51799", "predicate": "biolink:affects", "object": "PANTHER.FAMILY:PTHR22935", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01598_MESH_D004697_1", "DB01598_MESH_D004716_1", "DB01598_MESH_D011018_1", "DB01598_MESH_D018410_1", "DB01598_MESH_D018784_1", "DB01598_MESH_D059413_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D015378", "original_object": "PANTHER.FAMILY:PTHR22935"}
{"subject": "GO:0019369", "predicate": "biolink:regulates", "object": "GO:0005886", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00711_MESH_D004604_1", "DB00711_MESH_D008118_1", "DB00711_MESH_D009855_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019369", "original_object": "GO:0005886"}
{"subject": "UBERON:0005290", "predicate": "biolink:develops_from", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0005290", "original_object": "NCBITaxon:6072"}
{"subject": "MONDO:0020598", "predicate": "biolink:negatively_correlated_with", "object": "GO:0006879", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00115_MESH_D018798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008286", "original_object": "GO:0006879"}
{"subject": "CHEBI:17196", "predicate": "biolink:similar_to", "object": "UMLS:C0001898", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00174", "original_object": "DRUGBANK:DB00160"}
{"object": "HGNC.FAMILY:563", "predicate": "biolink:has_participant", "subject": "GO:0022851", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00794_MESH_D004827_1", "DB00794_MESH_D004828_1", "DB00794_MESH_D004830_1", "DB00794_MESH_D012640_1", "DB00794_MESH_D065768_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HGNC.FAMILY:563", "original_subject": "GO:0022851"}
{"subject": "HP:0012535", "predicate": "biolink:correlated_with", "object": "HP:0002121", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00347_MESH_D004832_2", "DB05246_MESH_D004832_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012535", "original_object": "HP:0002121"}
{"object": "MONDO:0006594", "predicate": "biolink:causes", "subject": "GO:0030057", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0006594", "original_subject": "GO:0030057"}
{"subject": "REACT:R-HSA-1592389", "predicate": "biolink:regulates", "object": "HP:0100773", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00026_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "REACT:R-HSA-1592389", "original_object": "HP:0100773"}
{"subject": "GO:0141067", "predicate": "biolink:related_to", "object": "CHEBI:17997", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0141067", "original_object": "CHEBI:17997"}
{"subject": "NCBIGene:150", "predicate": "biolink:treats", "object": "MONDO:0005302", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01018_MESH_D001289_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08913", "original_object": "MESH:D001289"}
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{"subject": "GO:1990658", "predicate": "biolink:related_to", "object": "CHEBI:16480", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990658", "original_object": "CHEBI:16480"}
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{"subject": "REACT:R-HSA-2162123", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0005277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D008881_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-2162123", "original_object": "MESH:D008881"}
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{"subject": "UNII:Z633861EIM", "predicate": "biolink:affects", "object": "CHEBI:29888", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09105_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:C570710", "original_object": "MESH:C107241"}
{"subject": "HGNC.FAMILY:180", "predicate": "biolink:regulates", "object": "GO:0007213", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01239_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "HGNC.FAMILY:180", "original_object": "GO:0007213"}
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{"subject": "GO:0016616", "predicate": "biolink:regulates", "object": "CHEBI:26333", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02329_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0016616", "original_object": "MESH:D011453"}
{"subject": "CL:0002061", "predicate": "biolink:related_to", "object": "NCBITaxon:6231", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0002061", "original_object": "NCBITaxon:6231"}
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{"subject": "GO:0042600", "predicate": "biolink:related_to", "object": "UBERON:0007010", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003124", "original_object": "UBERON:0007010"}
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{"object": "CHEBI:4534", "predicate": "biolink:has_metabolite", "subject": "PUBCHEM.COMPOUND:174173", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01501_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:C100010", "original_subject": "MESH:C028792"}
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{"subject": "CHEBI:176783", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:22652", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01698_MESH_D001206_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:176783", "original_object": "MESH:D001205"}
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{"subject": "NCBIGene:1636", "predicate": "biolink:produces", "object": "CHEBI:2719", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00790_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P12821", "original_object": "MESH:D000804"}
{"subject": "UBERON:0002439", "predicate": "biolink:regulates", "object": "UBERON:0004221", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00836_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0002439", "original_object": "UBERON:0004221"}
{"subject": "CHEBI:33325", "predicate": "biolink:positively_correlated_with", "object": "GO:0035861", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08913_MESH_D011471_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C581106", "original_object": "GO:0035861"}
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{"subject": "NCBIGene:7046", "predicate": "biolink:affects", "object": "REACT:R-HSA-381377", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activation", "subject_context_qualifier": "UniProtKB:P01137", "anatomical_context_qualifier": "UMLS:C0334227", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:33731701"], "primary_knowledge_source": "infores:ccidb", "original_subject": "UniProtKB:P36897", "original_object": "REACT:R-HSA-381377"}
{"subject": "HP:4000007", "predicate": "biolink:positively_correlated_with", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08897_MESH_D029424_1", "DB13036_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:4000007", "original_object": "GO:0006954"}
{"subject": "CHEBI:3314", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0022650", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4433", "original_object": "UMLS:C0022650"}
{"subject": "GO:0030548", "predicate": "biolink:causes", "object": "GO:0099565", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030548", "original_object": "GO:0099565"}
{"subject": "CHEBI:26519", "predicate": "biolink:disrupts", "object": "HP:0011355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00855_MESH_D055623_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005609", "original_object": "HP:0011355"}
{"subject": "UMLS:C0051846", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:64628", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06791_MESH_D000172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C060347", "original_object": "MESH:D013004"}
{"subject": "GO:0005764", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0002561", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01279_MESH_D009087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005764", "original_object": "MESH:D016464"}
{"subject": "CL:0000317", "predicate": "biolink:affects", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00655_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "CL:0000317", "original_object": "MESH:D012629"}
{"subject": "GO:0071159", "predicate": "biolink:affects", "object": "NCBIGene:7412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00806_MESH_D016491_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0071159", "original_object": "UniProtKB:P19320"}
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{"subject": "MONDO:0018149", "predicate": "biolink:affects", "object": "GO:0004565", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0008166", "original_object": "GO:0004565"}
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{"subject": "CHEBI:17933", "predicate": "biolink:has_active_ingredient", "object": "CHEBI:17823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11348_MESH_D006996_1", "DB11348_MESH_D010024_1", "DB11348_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002112", "original_object": "MESH:D002117"}
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{"subject": "REACT:R-HSA-1296059", "predicate": "biolink:correlated_with", "object": "HP:0002791", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01183_MESH_D009293_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-1296059", "original_object": "HP:0002791"}
{"subject": "CHEBI:31184", "predicate": "biolink:negatively_correlated_with", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D016410_1", "DB00240_MESH_D016460_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C021137", "original_object": "CHEBI:18295"}
{"subject": "GO:0095500", "predicate": "biolink:has_input", "object": "CHEBI:15355", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0095500", "original_object": "CHEBI:15355"}
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{"subject": "CL:4052008", "predicate": "biolink:coexists_with", "object": "CL:0002250", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4052008", "original_object": "CL:0002250"}
{"subject": "GO:0003677", "predicate": "biolink:correlated_with", "object": "GO:0006260", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01030_MESH_D010051_1", "DB01030_MESH_D055752_1", "DB12459_MESH_D002289_1", "DB12459_MESH_D010051_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0003677", "original_object": "GO:0006260"}
{"subject": "NCBITaxon:562", "predicate": "biolink:regulates", "object": "GO:0097272", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00994_MESH_D006501_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:562", "original_object": "GO:0097272"}
{"subject": "CHEBI:8869", "predicate": "biolink:negatively_correlated_with", "object": "GO:0016887", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00884_MESH_D010001_1", "DB00884_MESH_D010024_1", "DB00884_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000068296", "original_object": "GO:0016887"}
{"subject": "CHEBI:5801", "predicate": "biolink:negatively_correlated_with", "object": "HGNC.FAMILY:1296", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01611_MESH_D001172_1", "DB01611_MESH_D008179_1", "DB01611_MESH_D008180_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006886", "original_object": "HGNC.FAMILY:1296"}
{"subject": "CHEBI:28001", "predicate": "biolink:disrupts", "object": "UMLS:C0031164", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00512_MESH_D000071074_1", "DB00512_MESH_D004697_1", "DB00512_MESH_D004761_1", "DB00512_MESH_D011023_1", "DB00512_MESH_D013203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014640", "original_object": "UMLS:C0031164"}
{"subject": "CHEBI:27470", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0001700", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00650_MESH_D000749_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005492", "original_object": "MESH:D000749"}
{"subject": "GO:0060077", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0100577", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09118_MESH_D004831_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060077", "original_object": "MESH:D004831"}
{"subject": "HP:0001510", "predicate": "biolink:contributes_to", "object": "CHEBI:27899", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6376191"], "tmkp_confidence_score": 0.6529963641100585, "sentences": "As shown in Figure 9C-D and Figure S18A, C, HT@CDDP induced a remarkable tumor growth delay and, 13 days after treatment, the tumor size (5.70 ? 1.14 mm3) was reduced by 82.78% compared with the untreated control (33.11 ? 4.63 mm3).|NA", "tmkp_ids": ["tmkp:13577809435a7de92b00b14fc5a14ff8c010a136e900860b78ae02928a9088ea"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "HP:0001510", "original_object": "DRUGBANK:DB00515"}
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{"subject": "CHEBI:16865", "predicate": "biolink:correlated_with", "object": "GO:0060077", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09118_MESH_D004831_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16865", "original_object": "GO:0060077"}
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{"subject": "CHEBI:135934", "predicate": "biolink:disrupts", "object": "NCBITaxon:55194", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00971_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C025698", "original_object": "NCBITaxon:55194"}
{"subject": "GO:0006590", "predicate": "biolink:affects", "object": "CHEBI:60311", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00763_MESH_D006980_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0006590", "original_object": "MESH:D013963"}
{"object": "UBERON:0004027", "predicate": "biolink:has_part", "subject": "GO:0042600", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0004027", "original_subject": "UBERON:0003124"}
{"subject": "CHEBI:50114", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0001410", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04938_MESH_D004414_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004967", "original_object": "MESH:D059268"}
{"subject": "HP:0031377", "predicate": "biolink:located_in", "object": "UBERON:0002465", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00997_MESH_D002051_1", "DB00997_MESH_D008228_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0031377", "original_object": "UBERON:0002465"}
{"subject": "CHEBI:27306", "predicate": "biolink:interacts_with", "object": "NCBIGene:8566", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00165_MESH_D026681_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011736", "original_object": "UniProtKB:O00764"}
{"subject": "NCBIGene:2629", "predicate": "biolink:regulates", "object": "CHEBI:36500", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00053_MESH_D005776_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P04062", "original_object": "MESH:D005963"}
{"subject": "CHEBI:24838", "predicate": "biolink:correlated_with", "object": "HP:0100529", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09561_MESH_D017674_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:24838", "original_object": "HP:0100529"}
{"subject": "UBERON:0001133", "predicate": "biolink:affects", "object": "MONDO:0000745", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00326_MESH_D006323_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UBERON:0001133", "original_object": "MESH:D006323"}
{"subject": "CHEBI:39026", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005098", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00175_MESH_D020521_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008077", "original_object": "MESH:D020521"}
{"subject": "NCBIGene:2798", "predicate": "biolink:target_for", "object": "UMLS:C0029967", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06785_MESH_D010062_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P30968", "original_object": "UMLS:C0029967"}
{"subject": "CHEBI:26519", "predicate": "biolink:positively_correlated_with", "object": "GO:0036480", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12131_MESH_D003704_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005609", "original_object": "GO:0036480"}
{"subject": "GO:0035623", "predicate": "biolink:correlated_with", "object": "MESH:D001786", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11824_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0035623", "original_object": "MESH:D001786"}
{"subject": "UBERON:0004716", "predicate": "biolink:develops_from", "object": "CL:0000365", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004716", "original_object": "CL:0000365"}
{"subject": "MESH:C006632", "predicate": "biolink:affects", "object": "CHEBI:26523", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01169_MESH_D015473_1", "DB01169_MESH_D015479_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:C006632", "original_object": "CHEBI:26523"}
{"subject": "UMLS:C0030956", "predicate": "biolink:decreases_sensitivity_to", "object": "NCBIGene:3481", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "NCBITaxon:9606", "publications": ["PMID:24055520"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010455", "original_object": "NCBIGENE:3481"}
{"subject": "UBERON:0001013", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0012104", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09046_MESH_C562448_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001013", "original_object": "MESH:C562448"}
{"object": "NCBIGene:45025512", "predicate": "biolink:produces", "subject": "NCBITaxon:1392", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DBDB08902_MESH_C571912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P13423", "original_subject": "NCBITaxon:1392"}
{"subject": "UBERON:0003956", "predicate": "biolink:negatively_correlated_with", "object": "HP:0007906", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00484_MESH_D005902_2", "DB01085_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003956", "original_object": "HP:0007906"}
{"subject": "NCBIGene:3350", "predicate": "biolink:correlated_with", "object": "CHEBI:28790", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12833_MESH_D002012_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08908", "original_object": "MESH:D012701"}
{"subject": "UNII:Z633861EIM", "predicate": "biolink:similar_to", "object": "NCBIGene:249", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05768_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB05768", "original_object": "UniProtKB:P05186"}
{"subject": "GO:0005237", "predicate": "biolink:negatively_correlated_with", "object": "HP:0002360", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00962_MESH_D007319_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005237", "original_object": "HP:0002360"}
{"subject": "UBERON:0011357", "predicate": "biolink:composed_primarily_of", "object": "PR:000015658", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0011357", "original_object": "PR:000015658"}
{"subject": "HGNC.FAMILY:2086", "predicate": "biolink:affects", "object": "NCBIGene:2167", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "HGNC.FAMILY:2086", "original_object": "UniProtKB:P15090"}
{"subject": "HP:0031826", "predicate": "biolink:precedes", "object": "HP:0003394", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00924_MESH_D009128_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0031826", "original_object": "HP:0003394"}
{"subject": "CHEBI:17154", "predicate": "biolink:affects", "object": "REACT:R-HSA-181438", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D009536", "original_object": "REACT:R-HSA-181438"}
{"subject": "UMLS:C0079189", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB07615_MESH_D003876_2", "DB07615_MESH_D065631_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D016207", "original_object": "GO:0006954"}
{"subject": "CHEBI:26333", "predicate": "biolink:occurs_in", "object": "UBERON:0000955", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08797_MESH_D005334_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011453", "original_object": "UBERON:0000955"}
{"subject": "UBERON:0010210", "predicate": "biolink:predisposes_to_condition", "object": "HP:0001907", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00266_MESH_D013923_1", "DB00946_MESH_D013923_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010210", "original_object": "MESH:D013923"}
{"subject": "REACT:R-HSA-390651", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005090", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13676_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-390651", "original_object": "MESH:D012559"}
{"subject": "HP:0001257", "predicate": "biolink:negatively_correlated_with", "object": "GO:0022414", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00848_MESH_D000724_1", "DB00848_MESH_D001196_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001257", "original_object": "GO:0022414"}
{"subject": "CHEBI:16933", "predicate": "biolink:contributes_to", "object": "GO:0009277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06636_MESH_D001228_1", "DB06636_MESH_D009091_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16933", "original_object": "GO:0009277"}
{"subject": "CHEBI:17489", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00195_MESH_D005902_1", "DB00195_MESH_D009798_1", "DB00484_MESH_D005902_2", "DB00484_MESH_D009798_2", "DB00521_MESH_D005902_1", "DB00521_MESH_D009798_1", "DB09351_MESH_D005902_1", "DB09351_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17489", "original_object": "UBERON:0001796"}
{"subject": "UNII:S866O45PIG", "predicate": "biolink:chemically_similar_to", "object": "UBERON:0008826", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06761_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C072197", "original_object": "UBERON:0008826"}
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{"subject": "GO:0000305", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00911_MESH_D005873_1", "DB00911_MESH_D008101_1", "DB00911_MESH_D014245_1", "DB00911_MESH_D016585_1", "DB11989_MESH_D014355_1", "DB12834_MESH_D005873_1", "DB12834_MESH_D014245_1", "DB12834_MESH_D016585_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000305", "original_object": "MESH:D004247"}
{"subject": "CHEBI:50580", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0030163", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:237", "original_object": "UMLS:C0030163"}
{"subject": "GO:0007212", "predicate": "biolink:has_participant", "object": "CL:0000700", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007212", "original_object": "CL:0000700"}
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{"subject": "HGNC.FAMILY:181", "predicate": "biolink:negatively_correlated_with", "object": "HP:0002071", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01186_MESH_D020734_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:181", "original_object": "HP:0002071"}
{"subject": "GO:0004714", "predicate": "biolink:regulates", "object": "HP:0031377", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01254_MESH_D001752_1", "DB01254_MESH_D015466_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004714", "original_object": "HP:0031377"}
{"subject": "NCBIGene:5468", "predicate": "biolink:directly_physically_interacts_with", "object": "HGNC.FAMILY:2086", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P37231", "original_object": "HGNC.FAMILY:2086"}
{"subject": "UBERON:0025525", "predicate": "biolink:negatively_correlated_with", "object": "HP:0030895", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08890_MESH_D043183_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0025525", "original_object": "HP:0030895"}
{"subject": "UMLS:C1172636", "predicate": "biolink:disrupts", "object": "CHEBI:8005", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06219_MESH_D013207_1", "DB06219_MESH_D017192_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C469289", "original_object": "CHEBI:8005"}
{"subject": "REACT:R-HSA-70171", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5833", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00468_MESH_D016778_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-70171", "original_object": "NCBITaxon:5833"}
{"subject": "CHEBI:7566", "predicate": "biolink:produces", "object": "CHEBI:26523", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11820_MESH_D014355_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009547", "original_object": "CHEBI:26523"}
{"subject": "MONDO:0004992", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "NCBIGene:213", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5602453", "PMC:9053164"], "tmkp_confidence_score": 0.2376184596187509, "sentences": "Compared to other singular treatment groups, P@-Gem-HSA-NPs (L+) showed a highly synergistic effect in destructing cancer cells by in vitro of combined PDT and chemotherapy (P<0.05).|NA|The greater therapeutic efficiency of CTAC@MSNs-HSA is mainly attributed to the presence of HSA, which increase the cell uptake of nanomaterials and improve their biocompatibility, thus provide the prolonged cytotoxicity of nanomaterials against cancer cells.|NA", "tmkp_ids": ["tmkp:1acfe86ef33199d48c9ac06fad51f1920786bbdfb9cd770915c4e40870282a08", "tmkp:5272965de4ad6fe3443e0d85771f30656c98ea423b21852c97ea5ea3111ee866"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "MONDO:0004992", "original_object": "DRUGBANK:DB00062"}