{"subject": "PUBCHEM.COMPOUND:44274699", "predicate": "biolink:affects", "object": "NCBIGene:5770", "affinity_parameter": "pIC50", "supporting_affinities": [6.89], "publications": ["PMID:10753467"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 6.89, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:44274699", "original_object": "UniProtKB:P18031", "object_aspect_qualifier": "activity", "object_direction_qualifier": "decreased", "qualified_predicate": "biolink:causes"}
{"subject": "NCBITaxon:1706470", "predicate": "biolink:related_to", "object": "NCBITaxon:1706470", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1706470", "original_object": "NCBITaxon:1706470"}
{"subject": "NCBIGene:3458", "predicate": "biolink:actively_involved_in", "object": "GO:0006913", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["NCBI gene2go"], "original_subject": "NCBIGene:3458", "original_object": "GO:0006913"}
{"subject": "CHEBI:68579", "predicate": "biolink:contributes_to", "object": "MONDO:0002251", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5156547", "PMC:2730547", "PMC:5003057"], "tmkp_confidence_score": 0.6128887859621844, "sentences": "Aside from bleeding, some of the additional side effects of rivaroxaban include the following: dizziness (6%), peripheral edema (6%), hypersensitivity reactions or rash (2%), syncope (2%), and though more rare, thrombocytopenia, agranulocytosis, hepatitis, pruritis, and Stevens?Johnson syndrome.|NA|In the third patient, rivaroxaban was stopped after 23 d, when hepatitis B with seroconversion was diagnosed; the patient died of acute liver failure, mostly due to fatal hepatitis B infection, 48 d after starting treatment.|NA|Non-hemorrhagic adverse effects of rivaroxaban in the EINSTEIN-EXT study were upper abdominal pain, dyspepsia, sinusitis, tooth ache, UTI, back pain and fatigue (all less than 5%) whereas post marketing voluntary reporting of adverse effects include anaphylaxis, angioedema, Stevens-Johnson syndrome, agranulocytosis, jaundice and hepatitis.|NA", "tmkp_ids": ["tmkp:21709dfe811f66a9f620d41080651d41e3d1d379af32db099f3d5a7b494bb6cb", "tmkp:fd2d3e43f75ceac886f3de1b65395369865a1648efc1371ea27bc5b724668584", "tmkp:a62f721434da7ccccc0aee9c2709dc7e571c1caea24237d2ce5dee0cb76a9958"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB06228", "original_object": "MONDO:0002251"}
{"subject": "NCBIGene:836088", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:836392", "primary_knowledge_source": "infores:intact", "publications": "PMID:30806640", "detection_method": "MI:0892", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UniProtKB:Q9FN94", "original_object": "UniProtKB:Q8GX94"}
{"subject": "NCBITaxon:556533", "predicate": "biolink:subclass_of", "object": "NCBITaxon:286", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:556533", "original_object": "NCBITaxon:286"}
{"subject": "NCBIGene:1376", "predicate": "biolink:affects", "object": "PUBCHEM.COMPOUND:131757099", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P23786", "original_object": "HMDB:HMDB0046150", "object_aspect_qualifier": "abundance"}
{"object": "CHEBI:29888", "predicate": "biolink:has_participant", "subject": "SMPDB:SMP0048300", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HMDB:HMDB0000250", "original_subject": "SMPDB:SMP0048300"}
{"subject": "NCBIGene:4539", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:4728", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000354728", "original_object": "ENSEMBL:ENSP00000315774"}
{"subject": "UBERON:0001709", "predicate": "biolink:overlaps", "object": "UBERON:0001434", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001709", "original_object": "UBERON:0001434"}
{"subject": "CHEBI:189354", "predicate": "biolink:subclass_of", "object": "CHEBI:76224", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:189354", "original_object": "CHEBI:76224"}
{"subject": "UMLS:C0042071", "predicate": "biolink:affects", "object": "NCBIGene:1869", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:3180375"], "tmkp_confidence_score": 0.92332244, "sentences": "E2F1 has also been shown to act as a direct transcriptional repressor for several genes including urokinase-type PA (uPA), the anti-apoptotic protein Mcl-1, and human telomerase reverse transcriptase.|NA", "tmkp_ids": ["tmkp:c2b25e7c4396611937af1c47ba8964c4039d84421f3a7d5e9a346ee1573ea3ce"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "DRUGBANK:DB00013", "original_object": "UniProtKB:Q01094"}
{"subject": "NCBIGene:29127", "predicate": "biolink:affects", "object": "NCBIGene:1894", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:8241731", "PMC:8241731", "PMID:33485843", "PMC:6784142"], "tmkp_confidence_score": 0.97159785, "sentences": "It has also been revealed that RACGAP1 could be converted to RhoA-specific GAP by Aurora B. Others reported that RACGAP1 increased RhoA activity by stabilizing ECT2.|NA|A recent study on breast cancer revealed that RACGAP1 promotes mitochondrial dynamic driven metastasis through recruiting ECT2 and subsequently activating ERK-DRP1 pathway.|NA|We showed that RACGAP1 promoted mitochondrial fission through recruiting ECT2 during anaphase and subsequently had activated ERK-DRP1 pathway.|NA|In addition, the authors provided multiple lines of evidence to show that the GAP domain of MgcRacGAP/CYK-4 contributes to RhoA-mediated contractility, presumably through ECT2 activation.|NA", "tmkp_ids": ["tmkp:9e83192c6e107494e0354377e87f368af9627801414a32d38ca7a2bbd9f906d2", "tmkp:98023478f5073336204a684617dde1f649e287ab681bb81889e9e69365dd42f2", "tmkp:2a468305ca8e0e76cc08974c67617b3ab2855b8b89a798170b022036199485e0", "tmkp:6f0c1789bde2eeb2035cc8821640f17f50567ca5a1b90351ec29230add54baac"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "UniProtKB:Q9H0H5", "original_object": "UniProtKB:Q9H8V3"}
{"object": "REACT:R-PFA-77108", "predicate": "biolink:occurs_in", "subject": "REACT:R-PFA-74181", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-PFA-77108", "original_subject": "REACT:R-PFA-74181"}
{"subject": "MP:0030531", "predicate": "biolink:subclass_of", "object": "MP:0003743", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MP:0030531", "original_object": "MP:0003743"}
{"subject": "CHEBI:15367", "predicate": "biolink:affects", "object": "NCBIGene:4908", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMID:15857687", "PMID:15857687"], "tmkp_confidence_score": 0.99738718, "sentences": "We have previously shown that bone morphogenetic protein-2 (BMP2) and retinoic acid synergistically induce the responsiveness of developing sympathetic neurons to neurotrophic factors, neurotrophin 3 (NT-3), and GDNF by upregulating corresponding receptors concomitantly with the induction of other neuron-specific genes including BRINP1, a neuron-specific cell-cycle regulatory protein.|NA|We have previously shown that bone morphogenetic protein-2 (BMP2) and retinoic acid synergistically induce the responsiveness of developing sympathetic neurons to neurotrophic factors, neurotrophin 3 (NT-3), and GDNF by upregulating corresponding receptors concomitantly with the induction of other neuron-specific genes including BRINP1, a neuron-specific cell-cycle regulatory protein.|NA", "tmkp_ids": ["tmkp:49bca3d875c536a01f52821324cecc6f4f2eb2f67a8b64c2b07bd146259477ed", "tmkp:c82acfae7f1af8342d1f2c6631e6745145479574df11f63b6fa281e31aecefa0"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "DRUGBANK:DB00755", "original_object": "UniProtKB:P20783"}
{"subject": "REACT:R-SPO-191983", "predicate": "biolink:has_input", "object": "CHEBI:57783", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SPO-191983", "original_object": "CHEBI:57783"}
{"subject": "NCBIGene:388", "predicate": "biolink:regulates", "object": "NCBIGene:1058", "primary_knowledge_source": "infores:lincs", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "NCBIGene:388", "original_object": "NCBIGene:1058"}
{"object": "NCBIGene:10296", "predicate": "biolink:has_part", "subject": "HGNC.FAMILY:1561", "primary_knowledge_source": "infores:hgnc", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:9763581"], "original_object": "HGNC:13731", "original_subject": "HGNC.FAMILY:1561"}
{"subject": "PANTHER.FAMILY:PTHR22884:SF473", "predicate": "biolink:actively_involved_in", "object": "GO:2001141", "primary_knowledge_source": "infores:panther", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR22884:SF473", "original_object": "GO:2001141"}
{"subject": "PUBCHEM.COMPOUND:118207377", "predicate": "biolink:related_to", "object": "NCBIGene:24410", "affinity_parameter": "pKi", "supporting_affinities": [8.8], "pubchem_assay_ids": ["PUBCHEM.AID:aid1802064"], "patent_ids": ["PATENT:US9221796"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 8.8, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:118207377", "original_object": "UniProtKB:Q00960"}
{"subject": "CHEBI:17833", "predicate": "biolink:contributes_to", "object": "HP:0002153", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:4458901"], "tmkp_confidence_score": 0.7844641251799579, "sentences": "Hyperkalemia produced due to GM was normalized in BA treated group substantiating its protective effect and was statistically significant.|NA", "tmkp_ids": ["tmkp:ad05984693525a034f7444d7d21418117b9a87c9fea96e2fc4c2bc584449c4ac"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00798", "original_object": "HP:0002153"}
{"subject": "CHEBI:74947", "predicate": "biolink:causes", "object": "HP:0001288", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01041", "original_object": "UMLS:C0575081"}
{"subject": "NCBIGene:11235", "predicate": "biolink:expressed_in", "object": "UBERON:0001911", "primary_knowledge_source": "infores:bgee", "knowledge_level": "observation", "agent_type": "data_analysis_pipeline", "adjusted_p_value": 1e-14, "has_confidence_level": "gold quality", "has_confidence_score": 94.34, "bgee_expression_rank": 2640.0, "original_subject": "ENSEMBL:ENSG00000114209", "original_object": "UBERON:0001911"}
{"subject": "CHEMBL.COMPOUND:CHEMBL1182657", "predicate": "biolink:has_adverse_event", "object": "UMLS:C0235378", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 20.4, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2677", "original_object": "MEDDRA:10019851"}
{"object": "REACT:R-HSA-69473", "predicate": "biolink:occurs_in", "subject": "REACT:R-HSA-75035", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-HSA-69473", "original_subject": "REACT:R-HSA-75035"}
{"subject": "PANTHER.FAMILY:PTHR11706:SF52", "predicate": "biolink:located_in", "object": "GO:0098852", "primary_knowledge_source": "infores:panther", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "PANTHER.FAMILY:PTHR11706:SF52", "original_object": "GO:0098852"}
{"subject": "UMLS:C1709028", "predicate": "biolink:subclass_of", "object": "MONDO:0006456", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C45708", "original_object": "NCIT:C3411"}
{"subject": "GO:0060856", "predicate": "biolink:in_taxon", "object": "NCBITaxon:33213", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060856", "original_object": "NCBITaxon:33213"}
{"subject": "NCBIGene:14184", "predicate": "biolink:has_phenotype", "object": "MP:0000566", "primary_knowledge_source": "infores:mgi", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:agrkb"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:19086028"], "id": "uuid:f494b9a8-7501-11f1-b226-0725f7b8bc21", "category": ["biolink:GeneToPhenotypicFeatureAssociation", "biolink:EntityToPhenotypicFeatureAssociationMixin", "biolink:GeneToEntityAssociationMixin", "biolink:Association", "biolink:Entity", "biolink:FrequencyQuantifier", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin", "biolink:RelationshipQuantifier"], "file_source": "alliance_phenotype_edges", "provided_by": "alliance_phenotype_edges", "evidence_count": 1, "grouping_key": "MGI:95524||biolink:has_phenotype|MP:0000566", "original_subject": "MGI:95524", "original_object": "MP:0000566"}
{"subject": "MONDO:0002334", "predicate": "biolink:related_to", "object": "NCBIGene:5295", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["DisGeNET"], "original_subject": "DOID:2531", "original_object": "NCBIGene:5295"}
{"subject": "MONDO:0014527", "predicate": "biolink:has_phenotype", "object": "MONDO:0020378", "primary_knowledge_source": "infores:omim", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:hpo-annotations"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "id": "uuid:6fa6aa11-7683-11f1-b7fc-6045bd002667", "category": ["biolink:DiseaseToPhenotypicFeatureAssociation", "biolink:FrequencyQuantifier", "biolink:EntityToPhenotypicFeatureAssociationMixin", "biolink:DiseaseToEntityAssociationMixin", "biolink:Association", "biolink:Entity", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin", "biolink:RelationshipQuantifier"], "file_source": "hpoa_disease_to_phenotype_edges", "provided_by": "hpoa_disease_to_phenotype_edges", "has_evidence": ["ECO:0000304"], "original_subject": "MONDO:0014527", "evidence_count": 1, "grouping_key": "MONDO:0014527|False|biolink:has_phenotype|HP:0007787", "original_object": "HP:0007787"}
{"subject": "CHEBI:43755", "predicate": "biolink:has_adverse_event", "object": "MONDO:0005609", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 30.654, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1587", "original_object": "MEDDRA:10019974"}
{"subject": "NCBIGene:113235", "predicate": "biolink:increases_sensitivity_to", "object": "CHEBI:44185", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "NCBITaxon:9606", "publications": ["PMID:21879757", "PMID:25124723"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:113235", "original_object": "MESH:D008727"}
{"subject": "NCBIGene:6331", "predicate": "biolink:has_phenotype", "object": "MONDO:0000190", "primary_knowledge_source": "infores:hpo-annotations", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "logical_entailment", "agent_type": "automated_agent", "id": "uuid:664c7715-7683-11f1-b7fc-6045bd002667", "category": ["biolink:GeneToPhenotypicFeatureAssociation", "biolink:EntityToPhenotypicFeatureAssociationMixin", "biolink:GeneToEntityAssociationMixin", "biolink:Association", "biolink:Entity", "biolink:FrequencyQuantifier", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin", "biolink:RelationshipQuantifier"], "file_source": "hpoa_gene_to_phenotype_edges", "provided_by": "hpoa_gene_to_phenotype_edges", "disease_context_qualifier": "OMIM:603829", "original_subject": "HGNC:10593", "grouping_key": "HGNC:10593||biolink:has_phenotype|HP:0001663", "original_object": "HP:0001663"}
{"object": "UBERON:0005408", "predicate": "biolink:has_part", "subject": "UBERON:0000955", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "EMAPA:35243", "original_subject": "EMAPA:16894"}
{"subject": "NCBIGene:6658", "predicate": "biolink:causes", "object": "MONDO:0010252", "primary_knowledge_source": "infores:omim", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "not_provided", "agent_type": "not_provided", "id": "uuid:0fd89993-6314-44de-92cf-e824840e7d04", "category": ["biolink:CausalGeneToDiseaseAssociation", "biolink:GeneToEntityAssociationMixin", "biolink:Association", "biolink:Entity"], "file_source": "omim_gene_to_disease_edges", "provided_by": "omim_gene_to_disease_edges", "original_subject": "HGNC:11199", "original_object": "MONDO:0010252", "grouping_key": "HGNC:11199||biolink:causes|MONDO:0010252"}
{"subject": "NCBIGene:8483", "predicate": "biolink:interacts_with", "object": "NCBIGene:1299", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "ENSEMBL:ENSP00000261883", "original_object": "ENSEMBL:ENSP00000496793"}
{"subject": "CHEBI:37941", "predicate": "biolink:regulates", "object": "NCBIGene:6241", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:60606", "original_object": "HGNC:10452", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "NCBIGene:6678", "predicate": "biolink:genetically_associated_with", "object": "MONDO:0005010", "primary_knowledge_source": "infores:ctd", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "prediction", "agent_type": "manual_agent", "original_subject": "HGNC:11219", "original_object": "DOID:3393"}
{"subject": "CHEBI:41500", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0008322", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6168010"], "tmkp_confidence_score": 1.044830170792626, "sentences": "Our first therapeutic approach to treat PSACH in our MT-COMP mouse was administration of ER stress reducing, drugs valproate, lithium and phenylbutyric acid from birth until 4 weeks after birth.|NA", "tmkp_ids": ["tmkp:a8823fbb4e8b65e6e3c7935dbbeec975cbcdf00af0948ee62768e31464156d40"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB06819", "original_object": "MONDO:0008322"}
{"subject": "CHEBI:51298", "predicate": "biolink:subclass_of", "object": "CHEBI:51269", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:51298", "original_object": "CHEBI:51269"}
{"subject": "PUBCHEM.COMPOUND:131781814", "predicate": "biolink:correlated_with", "object": "MONDO:0010543", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:16973164", "PMID:1719174", "PMID:10484795"], "original_subject": "HMDB:HMDB0075043", "original_object": "OMIM:302060"}
{"subject": "NCBIGene:10500", "predicate": "biolink:catalyzes", "object": "GO:0030215", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["NCBI gene2go"], "original_subject": "NCBIGene:10500", "original_object": "GO:0030215"}
{"subject": "UBERON:0016476", "predicate": "biolink:related_to", "object": "UBERON:0016476", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0016476", "original_object": "UBERON:0016476"}
{"subject": "NCBIGene:10330", "predicate": "biolink:expressed_in", "object": "UBERON:0000465", "primary_knowledge_source": "infores:bgee", "knowledge_level": "observation", "agent_type": "data_analysis_pipeline", "adjusted_p_value": 1e-14, "has_confidence_level": "gold quality", "has_confidence_score": 93.38, "bgee_expression_rank": 3090.0, "original_subject": "ENSEMBL:ENSG00000257727", "original_object": "UBERON:0000465"}
{"subject": "NCBIGene:83463", "predicate": "biolink:subclass_of", "object": "PR:000010791", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:Q9BW11", "original_object": "PR:000010791"}
{"object": "NCBIGene:29924", "predicate": "biolink:has_part", "subject": "GO:0030125", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_object": "UniProtKB:Q9Y6I3", "original_subject": "GO:0030125"}
{"subject": "UBERON:0002524", "predicate": "biolink:located_in", "object": "UBERON:0003728", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002524", "original_object": "UBERON:0003728"}
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{"subject": "UMLS:C0593103", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0019312", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:2291310"], "tmkp_confidence_score": 0.9275679898559188, "sentences": "Since then there have been a large number of reports on efficacy of rFVIIa in GT as well as other platelet function disorders including Bernard Soulier Syndrome; platelet storage pool defect including Hermansky-Pudlak syndrome, and platelet-type (pseudo) von Willebrand disease.|NA", "tmkp_ids": ["tmkp:b19b2f7a05b1c0a3a12e4d054bbd562caac8a7a9c7d813269f8ce6438f1b27c3"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00036", "original_object": "MONDO:0019312"}
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{"subject": "MESH:D012982", "predicate": "biolink:contributes_to", "object": "MONDO:0005044", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:1321309", "PMID:16870316", "PMID:40965513", "PMID:7989598", "PMID:8471231", "PMID:8982436"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D012982", "original_object": "MESH:D006973"}
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{"subject": "UniProtKB:Q8BX79-1", "predicate": "biolink:subclass_of", "object": "NCBIGene:338346", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:Q8BX79-1", "original_object": "PR:Q8BX79"}
{"subject": "CHEBI:178939", "predicate": "biolink:subclass_of", "object": "CHEBI:17855", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:178939", "original_object": "CHEBI:17855"}
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{"subject": "CHEBI:19775", "predicate": "biolink:related_to", "object": "CHEBI:18386", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:19775", "original_object": "CHEBI:18386"}
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{"subject": "NCBIGene:856657", "predicate": "biolink:expressed_in", "object": "GO:0031417", "primary_knowledge_source": "infores:sgd", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:agrkb"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:10504710"], "id": "uuid:526c44e2-7502-11f1-ae66-9ba462c02d39", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "file_source": "alliance_gene_to_expression_edges", "provided_by": "alliance_gene_to_expression_edges", "evidence_count": 1, "grouping_key": "SGD:S000000779||biolink:expressed_in|GO:0031417", "original_subject": "SGD:S000000779", "original_object": "GO:0031417"}
{"subject": "REACT:R-MMU-2046089", "predicate": "biolink:has_output", "object": "CHEBI:57540", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-MMU-2046089", "original_object": "CHEBI:57540"}
{"subject": "CHEBI:136060", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0013209", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5725959", "PMC:6539179"], "tmkp_confidence_score": 0.99949245, "sentences": "When coformulated with phosphatidylcholine and vitamin E, treatment of adult patients with NAFLD with silybin improved insulin resistance, liver histology and indices of hepatic and metabolic function.|NA|Silybin combined with phosphatidylcholine and vitamin E in patients with non alcoholic fatty liver disease: A randomized controlled trial|NA", "tmkp_ids": ["tmkp:b456ce3b0d14bfe680aae9add38b760969c9215d839e9198543885d9843f86c4", "tmkp:d5f5d06274ee41c62865bd2466e78d422be6672026497498c4f77b779d86837c"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "CHEBI:136060", "original_object": "MONDO:0013209"}
{"subject": "REACT:R-SPO-9845576", "predicate": "biolink:occurs_in", "object": "GO:0005829", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SPO-9845576", "original_object": "GO:0005829"}
{"subject": "CHEBI:36009", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0005267", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9113147", "PMC:4431415"], "tmkp_confidence_score": 0.5388464144180738, "sentences": "Some oils are also nutritionally important due to their requirement in a healthy diet including long-chain omega-3 and omega-6 fatty acids which have functions that help prevent heart disease and stroke (R?os-Covi?n et al.,).|NA|Furthermore, EPUFAs such as omega-3 and omega-6 fatty acids have important effects on the body, particularly relevant to enhancing appropriate pre- and postnatal development (mainly of the central and peripheral nervous systems), lowering cholesterol and triglyceride levels, reducing acute and chronic inflammation, treating patients with neurodegenerative disorders, contributing to blood pressure regulation, and reducing the odds of developing cancer, heart disease, and stroke.|NA", "tmkp_ids": ["tmkp:37dfbae222f18b02ab7dbcef8a1e2e484d06b585634ad7e8aa9bea767d72670f", "tmkp:b60a7e5818bb5934267b44b245e3c129299efee36a60f966a07c15c1eceaf367"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB13168", "original_object": "MONDO:0005267"}
{"subject": "MONDO:0015571", "predicate": "biolink:has_phenotype", "object": "HP:0001252", "primary_knowledge_source": "infores:orphanet", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:hpo-annotations"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "id": "uuid:76bc09a3-7683-11f1-b7fc-6045bd002667", "category": ["biolink:DiseaseToPhenotypicFeatureAssociation", "biolink:FrequencyQuantifier", "biolink:EntityToPhenotypicFeatureAssociationMixin", "biolink:DiseaseToEntityAssociationMixin", "biolink:Association", "biolink:Entity", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin", "biolink:RelationshipQuantifier"], "file_source": "hpoa_disease_to_phenotype_edges", "provided_by": "hpoa_disease_to_phenotype_edges", "has_evidence": ["ECO:0000304"], "frequency_qualifier": "HP:0040282", "original_subject": "MONDO:0015571", "evidence_count": 1, "grouping_key": "MONDO:0015571|False|biolink:has_phenotype|HP:0001252", "original_object": "HP:0001252"}
{"subject": "EMAPA:38260", "predicate": "biolink:subclass_of", "object": "UBERON:0006331", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "EMAPA:38260", "original_object": "EMAPA:32790"}
{"subject": "NCBIGene:6839", "predicate": "biolink:correlated_with", "object": "NCBIGene:51310", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["ERC"], "original_subject": "NCBIGene:6839", "original_object": "NCBIGene:51310"}
{"subject": "UBERON:0010062", "predicate": "biolink:develops_from", "object": "UBERON:0010020", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010062", "original_object": "UBERON:0010020"}
{"subject": "NCBIGene:328", "predicate": "biolink:capable_of", "object": "UMLS:C0094209", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C21415", "original_object": "NCIT:C16243"}
{"subject": "NCBIGene:84899", "predicate": "biolink:actively_involved_in", "object": "GO:0030968", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:Q5T4D3", "original_object": "GO:0030968"}
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{"subject": "CHEBI:144421", "predicate": "biolink:subclass_of", "object": "CHEBI:5975", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:144421", "original_object": "CHEBI:5975"}
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{"subject": "GO:0015156", "predicate": "biolink:subclass_of", "object": "GO:0015154", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015156", "original_object": "GO:0015154"}
{"subject": "EMAPA:17688", "predicate": "biolink:subclass_of", "object": "UBERON:0009621", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "EMAPA:17688", "original_object": "EMAPA:16860"}
{"subject": "NCBIGene:3475", "predicate": "biolink:active_in", "object": "GO:0005634", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:O00458", "original_object": "GO:0005634"}
{"object": "UBERON:0019290", "predicate": "biolink:has_part", "subject": "UBERON:0004069", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "EMAPA:35110", "original_subject": "EMAPA:35106"}
{"subject": "MONDO:0008487", "predicate": "biolink:regulates", "object": "NCBIGene:84266", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["STARGEO"], "original_subject": "DOID:11612", "original_object": "NCBIGene:84266", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "downregulated", "qualified_predicate": "biolink:causes"}
{"object": "GO:0098899", "predicate": "biolink:has_part", "subject": "GO:0097444", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0098899", "original_subject": "GO:0097444"}
{"subject": "REACT:R-BTA-9627104", "predicate": "biolink:has_input", "object": "UniProtKB:G3MWG5", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-BTA-9627104", "original_object": "UniProtKB:G3MWG5"}
{"subject": "GO:0043370", "predicate": "biolink:precedes", "object": "GO:0043367", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0043370", "original_object": "GO:0043367"}
{"subject": "CHEBI:9434", "predicate": "biolink:causes", "object": "UMLS:C0239571", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00966", "original_object": "UMLS:C0239571"}
{"object": "REACT:R-HSA-5624239", "predicate": "biolink:occurs_in", "subject": "REACT:R-HSA-428585", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-HSA-5624239", "original_subject": "REACT:R-HSA-428585"}
{"subject": "CHEBI:95075", "predicate": "biolink:subclass_of", "object": "CHEBI:38101", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:95075", "original_object": "CHEBI:38101"}
{"subject": "UMLS:C4331232", "predicate": "biolink:related_to", "object": "UMLS:C1402294", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C131501", "original_object": "NCIT:C40558"}
{"subject": "CHEBI:167638", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0271149", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1531", "original_object": "UMLS:C0271149"}
{"object": "MONDO:0026729", "predicate": "biolink:gene_associated_with_condition", "subject": "NCBIGene:84061", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0026729", "original_subject": "HGNC:28880"}
{"subject": "REACT:R-CFA-9756138", "predicate": "biolink:has_output", "object": "CHEBI:180932", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-CFA-9756138", "original_object": "CHEBI:180932"}
{"subject": "REACT:R-SSC-9728150", "predicate": "biolink:has_input", "object": "NCBIGene:100286743", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SSC-9728150", "original_object": "UniProtKB:I3LKT6"}
{"subject": "CHEBI:50729", "predicate": "biolink:contributes_to", "object": "HP:0002013", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:10597740", "PMID:11851027", "PMID:15333686"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008942", "original_object": "MESH:D014839"}
{"subject": "CHEBI:3207", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0002783", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:7708268", "PMC:7708268", "PMC:7708268"], "tmkp_confidence_score": 0.9865026, "sentences": "Budesonide/formoterol significantly reduces the frequency of these events versus formoterol alone, without an associated increase in the rate of LRTI and pneumonia.|NA|Finally, we assess whether therapy with budesonide/formoterol versus formoterol alone can reduce the frequency of, and outcomes associated with, COPD symptom-related attacks, and whether this addition of an inhaled corticosteroid (ICS) to a long-acting ?2-agonist (LABA) is associated with an increased incidence of lower respiratory tract infections (LRTI) and pneumonia.|NA|In addition to highlighting the incidence and importance of COPD symptom-related attacks, our analysis also showed that adding budesonide to formoterol significantly reduces the frequency of these attacks versus formoterol alone, without the increased risk of LRTI or pneumonia.|NA", "tmkp_ids": ["tmkp:8a00e41fc8ab25edc0b73ee2df14171a9a85d036a97261e177e600e8c936111c", "tmkp:63ffc9358890913b843d836527a07b7f8bb7f8112483f4184271ea6dec6b7444", "tmkp:02732dba589fa52d1e62ebfe15ab2ce76860307bd5e97a1287347fc86611ab98"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB01222", "original_object": "HP:0002783"}
{"subject": "CHEBI:34764", "predicate": "biolink:has_adverse_event", "object": "HP:0001155", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 547.154, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1198", "original_object": "MEDDRA:10061194"}
{"subject": "PR:000004036", "predicate": "biolink:subclass_of", "object": "CHEBI:36080", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:000004036", "original_object": "CHEBI:36080"}
{"subject": "NCBIGene:6927", "predicate": "biolink:genetically_associated_with", "object": "HP:0012051", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:11621", "original_object": "UMLS:C0271710"}
{"subject": "REACT:R-MMU-2022065", "predicate": "biolink:subclass_of", "object": "GO:0009306", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-MMU-2022065", "original_object": "GO:0009306"}
{"subject": "CHEBI:27732", "predicate": "biolink:treats", "object": "HP:0001257", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:463", "original_object": "UMLS:C0026838"}
{"subject": "UniProtKB:P14635-1", "predicate": "biolink:coexpressed_with", "object": "UniProtKB:Q96KB5-2", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "statistical_association", "agent_type": "data_analysis_pipeline", "original_subject": "ENSEMBL:ENSP00000256442", "original_object": "ENSEMBL:ENSP00000428489"}
{"subject": "UBERON:0006568", "predicate": "biolink:subclass_of", "object": "UBERON:0006569", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0006568", "original_object": "UBERON:0006569"}
{"subject": "MONDO:0005662", "predicate": "biolink:associated_with", "object": "HP:0002027", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0005662", "original_object": "HP:0002027"}
{"subject": "UBERON:0035549", "predicate": "biolink:located_in", "object": "UBERON:0002199", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0035549", "original_object": "UBERON:0002199"}
{"subject": "NCBIGene:116444", "predicate": "biolink:target_for", "object": "MONDO:0005180", "primary_knowledge_source": "infores:drugcentral", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC:16768", "original_object": "DOID:14330"}
{"subject": "GO:0046520", "predicate": "biolink:has_output", "object": "CHEBI:35785", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0046520", "original_object": "CHEBI:35785"}
{"subject": "UNII:K2J09EMJ52", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0032981", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2120", "original_object": "UMLS:C0032981"}
{"subject": "CHEBI:4315", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:2798", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["DrugBank (target)"], "original_subject": "DRUGBANK:DB01406", "original_object": "NCBIGene:2798"}
{"subject": "REACT:R-DRE-1296052", "predicate": "biolink:subclass_of", "object": "GO:1901381", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-DRE-1296052", "original_object": "GO:1901381"}
{"subject": "NCBIGene:6201", "predicate": "biolink:coexpressed_with", "object": "NCBIGene:6227", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000495273", "original_object": "ENSEMBL:ENSP00000345957"}
{"subject": "ComplexPortal:CPX-1134", "predicate": "biolink:actively_involved_in", "object": "GO:0031914", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:15537891"], "original_subject": "ComplexPortal:CPX-1134", "original_object": "GO:0031914"}
{"subject": "GO:0001537", "predicate": "biolink:has_participant", "object": "CHEBI:58339", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001537", "original_object": "CHEBI:58339"}
{"subject": "UBERON:0014612", "predicate": "biolink:in_taxon", "object": "NCBITaxon:7742", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0014612", "original_object": "NCBITaxon:7742"}
{"subject": "CHEBI:231347", "predicate": "biolink:related_to", "object": "CHEBI:38157", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:231347", "original_object": "CHEBI:38157"}
{"subject": "NCBIGene:513958", "predicate": "biolink:contributes_to", "object": "GO:0005085", "primary_knowledge_source": "infores:go", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["GO_REF:0000033"], "id": "uuid:43cfcd22-7cc4-11f1-8048-c96a56557525", "category": ["biolink:MacromolecularMachineToMolecularActivityAssociation", "biolink:MacromolecularMachineToEntityAssociationMixin", "biolink:FunctionalAssociation", "biolink:Association", "biolink:Entity"], "file_source": "go_annotation_edges", "provided_by": "go_annotation_edges", "has_evidence": ["ECO:0000318"], "species_context_qualifier": "NCBITaxon:9913", "original_subject": "NCBIGene:513958", "evidence_count": 2, "grouping_key": "NCBIGene:513958|False|biolink:contributes_to|GO:0005085", "original_object": "GO:0005085"}
{"subject": "CHEBI:17375", "predicate": "biolink:related_to", "object": "CHEBI:17893", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17375", "original_object": "CHEBI:17893"}
{"subject": "MP:0012309", "predicate": "biolink:affects", "object": "UBERON:0013701", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MP:0012309", "original_object": "UBERON:0013701"}
{"subject": "CL:4052011", "predicate": "biolink:temporally_related_to", "object": "GO:0048513", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4052011", "original_object": "GO:0048513"}
{"subject": "MESH:D014028", "predicate": "biolink:contributes_to", "object": "MONDO:0005302", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:34014325"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014028", "original_object": "MESH:D001289"}
{"subject": "CHEBI:121949", "predicate": "biolink:subclass_of", "object": "CHEBI:135639", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:121949", "original_object": "CHEBI:38785"}
{"object": "PANTHER.FAMILY:PTHR10405:SF33", "predicate": "biolink:has_part", "subject": "PANTHER.FAMILY:PTHR10405", "primary_knowledge_source": "infores:panther", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_object": "PANTHER.FAMILY:PTHR10405:SF33", "original_subject": "PANTHER.FAMILY:PTHR10405"}
{"subject": "CHEBI:25681", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0040270", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:2705820", "PMC:4886737", "PMC:5067287", "PMC:6522756"], "tmkp_confidence_score": 0.9020263, "sentences": "The Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial was the first large study to investigate the efficacy of long-term omega-3 fatty acid supplementation on cardiovascular events in individuals with CVD plus impaired glucose tolerance, impaired fasting glucose, or diabetes.|NA", "tmkp_ids": ["tmkp:809b7db9c7b7a0570e149645e1b016f3ec283a52dde3109e13574152b6dc0d51", "tmkp:9d3af4e05f503a5ad6cce5c334cc7694722ff97aaf76cf81c4f234ac3b7dcf9b", "tmkp:bd2736b9453a799e77b82f2057c75b43eca3eb81c67a9acaebbf06b894ce322e", "tmkp:cbb1f03888ef223807cf0d6356cbde9d401e119a3c9e518997c2d20d3f6bcfe1", "tmkp:ef2128a46b6b423549013e1484638bf27648f58b7313e8e42fb4d2aebfed4370"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "CHEBI:25681", "original_object": "HP:0040270"}
{"subject": "PUBCHEM.COMPOUND:9551646", "predicate": "biolink:affects", "object": "NCBIGene:1557", "primary_knowledge_source": "infores:pharos", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 6.8, "affinity_parameter": "pAC50", "original_subject": "CHEMBL.COMPOUND:CHEMBL1594359", "original_object": "HGNC:2621", "object_aspect_qualifier": "activity", "object_direction_qualifier": "increased", "qualified_predicate": "biolink:causes"}
{"subject": "NCBIGene:2268", "predicate": "biolink:colocalizes_with", "object": "GO:0015629", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:P09769", "original_object": "GO:0015629"}
{"subject": "PANTHER.PATHWAY:P06664", "predicate": "biolink:has_participant", "object": "PANTHER.FAMILY:PTHR23255:SF63", "primary_knowledge_source": "infores:panther", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "PANTHER.PATHWAY:P06664", "original_object": "PANTHER.FAMILY:PTHR23255:SF63"}
{"subject": "REACT:R-CEL-71130", "predicate": "biolink:has_output", "object": "CHEBI:59560", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-CEL-71130", "original_object": "CHEBI:59560"}
{"subject": "CHEBI:15443", "predicate": "biolink:affects", "object": "NCBIGene:6347", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:7648397", "PMC:3494429", "PMC:7563161", "PMID:28870713", "PMC:4476728"], "tmkp_confidence_score": 0.999687292, "sentences": "Other inflammatory and fibrosis-related genes such as Tnf?, Mcp-1, Col1a1, Timp1, Mmp2, and Mmp9 as well as macrophage or neutrophil genes such as F4/80, Cd11b, and Cd68 were induced by FPC diet intake and reduced by inulin (Fig.?3a).|NA|Inulin-type fructans administration to BaF3 mice decreased IL-4, IL-8 and MCP-1 levels (Figure 1E, I) with no significant effect on IL-10, G-CSF and RANTES levels (Figure 1G, H).|NA|Moreover, inulin, pectin, arabinoxylan and ?-glucan have been found to elevate IL-10/IL-12 ratio and to reduce the release of IFN-?, IL-12, IL-1, IL-6, IL-8, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory proteins (MIP)-1?, RANTES and TNF-? by dendritic cells.|NA|Only mice fed the inulin diet experienced an increase in serum lipopolysaccharide (LPS) and monocyte chemoattractant protein 1 (MCP-1), which was reversed when feeding the inulin?+?PomX diet.|NA|So far, we do not know if this decrease in MCP-1 could contribute, or would rather be the consequence of a decreased hepatic accumulation of BaF3 cells upon INU treatment.|NA", "tmkp_ids": ["tmkp:2344b27e2baf1e342015f4eb725923649dd6f6cac0681a13eef5ae3919352d5f", "tmkp:826639c5632b2561e84542dd47051ddf758572ba7ba6b7d4f523707433e55a5e", "tmkp:2a08069351dddda58ce377b3c27f3d9b9c4ef191639b1a799b69b88f84e3c57a", "tmkp:d63922b3b8c4f316f09dd7b44adb1c3ce8816e3ad0279ceba923c424978e09bd", "tmkp:6689f4a370957814c110338fa34d167c894d04f114704ed240dde036ffab9eb9"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "decreased", "original_subject": "DRUGBANK:DB00638", "original_object": "UniProtKB:P13500"}
{"subject": "UNII:G6UF363ECX", "predicate": "biolink:treats", "object": "MONDO:0850353", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5509", "original_object": "UMLS:C1328504"}
{"subject": "CHEBI:25879", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0234976", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2085", "original_object": "UMLS:C0234976"}
{"subject": "CHEBI:83629", "predicate": "biolink:has_part", "object": "CHEBI:27961", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:83629", "original_object": "CHEBI:27961"}
{"subject": "CHEBI:134564", "predicate": "biolink:affects", "object": "NCBIGene:10399", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:126212"], "tmkp_confidence_score": 0.9914415, "sentences": "RACK1 is a 36 kDa WD-repeat protein that was first identified as a protein that could bind to certain protein kinase C (PKC) isoforms subsequent to their activation by either diacylglycerol or phorbol esters such as PMA.|NA", "tmkp_ids": ["tmkp:f360e890e59c9431fcbf16e4c81367233d005419be652cd8ae24f146a36c223c"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "CHEBI:134564", "original_object": "UniProtKB:P63244"}
{"subject": "UNII:H4C81M8YYW", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:3286", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:24771824", "original_object": "PUBCHEM.COMPOUND:54746"}
{"subject": "CHEBI:28428", "predicate": "biolink:contributes_to", "object": "HP:0001622", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:26055944", "PMID:27748297"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C023888", "original_object": "MESH:D047928"}
{"object": "CL:0000861", "predicate": "biolink:has_participant", "subject": "GO:0006954", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0000861", "original_subject": "GO:0006954"}
{"subject": "CL:0007004", "predicate": "biolink:related_to", "object": "CL:0007004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0007004", "original_object": "CL:0007004"}
{"subject": "CHEBI:16134", "predicate": "biolink:related_to", "object": "NCBIGene:259307", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HMDB:HMDB0000051", "original_object": "UniProtKB:Q96RQ9"}
{"subject": "REACT:R-BTA-6784791", "predicate": "biolink:has_output", "object": "UniProtKB:F1MX38", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-BTA-6784791", "original_object": "UniProtKB:F1MX38"}
{"subject": "NCBIGene:6310", "predicate": "biolink:has_part", "object": "UMLS:C1522002", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C129917", "original_object": "NCIT:C13720"}
{"subject": "GO:0016122", "predicate": "biolink:has_participant", "object": "CHEBI:27325", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0016122", "original_object": "CHEBI:27325"}
{"subject": "REACT:R-MMU-69183", "predicate": "biolink:precedes", "object": "REACT:R-MMU-69091", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-MMU-69183", "original_object": "REACT:R-MMU-69091"}
{"object": "UBERON:0002013", "predicate": "biolink:has_part", "subject": "UBERON:0005303", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "EMAPA:19274", "original_subject": "EMAPA:18225"}
{"object": "GO:0001744", "predicate": "biolink:has_part", "subject": "GO:0001748", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0001744", "original_subject": "GO:0001748"}
{"subject": "UMLS:C0169964", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0012418", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6370160", "PMC:9254213", "PMC:9254213", "PMC:6370160", "PMC:9254213"], "tmkp_confidence_score": 0.7536605606871872, "sentences": "It has been reported that growth hormone replacement therapy can improve hypoxemia, but little is known of the hypoxemia in patients with GHD related to craniopharyngioma.|NA|The patient?s liver function and hypoxemia were improved by growth hormone replacement therapy, and liver transplantation was expected to be avoided.|NA|In this study, GH replacement therapy significantly improved liver function, metabolic status, and hypoxemia, providing new clinical support for the early diagnosis and treatment of NASH and HPS in children with hypopituitarism.|NA|After 3-month r-hGH replacement therapy, hypoxemia was improved significantly and the level of serum GH was elevated.|NA|A 29-year-old man with pituitary stalk interruption syndrome progressed slowly to HPS, and after 14 mo of treatment with recombinant human GH, the liver function and hypoxemia improved, and liver fibrosis did not progress.|NA", "tmkp_ids": ["tmkp:e96a33822d8cda1ae96b4b72b756feff259fe27ccdc33743b455fac0dd30424d", "tmkp:9f42bad62176a99fdd55c0b0a599a786d5e9be6d96705368aee8e47de1f9e2cc", "tmkp:b1658eae25c0ba5d39fe0b10b6b623558bd29a82d0097eac5b180f3cf77f5f06", "tmkp:74d2cbe2175346952af7ee806d64efcc09ceaa93d239c69a6a5c54344887f5f7", "tmkp:ec00e30ae746f22a14974181636924b04273904899e37e9cbd13b16f16482b71"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00052", "original_object": "HP:0012418"}
{"object": "NCBIGene:3688", "predicate": "biolink:has_participant", "subject": "UMLS:C1138422", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "NCIT:C96911", "original_subject": "NCIT:C177733"}
{"subject": "CHEBI:38495", "predicate": "biolink:contributes_to", "object": "HP:0005162", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5789123"], "tmkp_confidence_score": 1.3673890925739316, "sentences": "They reported that AlP intoxication was associated with left ventricular dysfunction, low ejection fraction, severe hypotension and electrocardiographic abnormalities.|NA", "tmkp_ids": ["tmkp:98008fe5edda95a1518722fd6159c5f650dfffd42f971ec9cca68ef2a7f87d70"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "CHEBI:38495", "original_object": "HP:0005162"}
{"subject": "CHEBI:81064", "predicate": "biolink:subclass_of", "object": "CHEBI:17334", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:81064", "original_object": "CHEBI:17334"}
{"subject": "NCBIGene:2052", "predicate": "biolink:genetically_associated_with", "object": "UMLS:C0010828", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:3401", "original_object": "UMLS:C0010828"}
{"subject": "CL:0000171", "predicate": "biolink:subclass_of", "object": "CL:0008024", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000171", "original_object": "CL:0008024"}
{"subject": "UBERON:0004983", "predicate": "biolink:in_taxon", "object": "NCBITaxon:7742", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004983", "original_object": "NCBITaxon:7742"}
{"subject": "CHEBI:42797", "predicate": "biolink:applied_to_treat", "object": "HP:0000989", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1264", "original_object": "UMLS:C0033774"}
{"subject": "UBERON:0036212", "predicate": "biolink:coexists_with", "object": "UBERON:0010887", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0036212", "original_object": "UBERON:0010887"}
{"subject": "REACT:R-HSA-8876993", "predicate": "biolink:has_output", "object": "NCBIGene:1500", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-8876993", "original_object": "UniProtKB:O60716"}
{"subject": "EMAPA:36770", "predicate": "biolink:subclass_of", "object": "UBERON:0006676", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "EMAPA:36770", "original_object": "EMAPA:35385"}
{"subject": "NCBIGene:40901", "predicate": "biolink:decreases_sensitivity_to", "object": "CHEBI:141474", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "NCBITaxon:30069", "publications": ["PMID:10692012", "PMID:3507466"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:40901", "original_object": "MESH:D008294"}
{"subject": "GO:0062153", "predicate": "biolink:has_part", "object": "GO:0003723", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0062153", "original_object": "GO:0003723"}
{"subject": "GO:0098564", "predicate": "biolink:related_to", "object": "GO:0098564", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098564", "original_object": "GO:0098564"}
{"subject": "UBERON:0002959", "predicate": "biolink:related_to", "object": "UBERON:0015233", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002959", "original_object": "UBERON:0015233"}
{"subject": "UNII:I60W9520VV", "predicate": "biolink:treats", "object": "UMLS:C0472713", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5420", "original_object": "UMLS:C0472713"}
{"subject": "CHEBI:16236", "predicate": "biolink:contributes_to", "object": "MONDO:0019167", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9079157", "PMC:9079157", "PMC:7315200", "PMC:7315200", "PMC:7315200"], "tmkp_confidence_score": 0.6752495598040993, "sentences": "Only 4 biopsy-proven cases of alcohol as a trigger for IgA vasculitis in adults have been reported.|NA|Here, we describe a case of recurrent IgA vasculitis triggered by alcohol and summarize the current literature about the theorized etiology and pathophysiology.|NA|Unlike the other cases of alcohol-associated IgA vasculitis, our patient was the only one to have extra-cutaneous manifestations; namely, scrotal edema and arthritis.|NA|Two patients with alcohol-associated IgA vasculitis, including our patient, experienced symptomatic purpuric eruptions: tenderness and burning pain, respectively.|NA|All previously reported cases of alcohol-related IgA vasculitis, with the exception of the 26-year-old woman, underwent comprehensive laboratory evaluation that was negative for underlying disease.|NA", "tmkp_ids": ["tmkp:6f12cce915935a2557a4ebe3cd3166d673c49851ff318fc49760c4e192b18eb9", "tmkp:d943dcd20a0ce4c3699fef186e9d2f43fc623acd2b072f180748b06c5d8dd5d1", "tmkp:e9771cc84048f1a921ca181a92d0bf63c813becab0d351b4281e994af71ee251", "tmkp:e8c2e433a310431fa622a1bbd6b2183b0d872afb135d85bb1c595922151f08f4", "tmkp:94f7e01b820c546b11b7178edd3879bf12f449c38a0c66c1c2b7184b689fb6dd"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00898", "original_object": "MONDO:0019167"}
{"subject": "CHEBI:16347", "predicate": "biolink:correlated_with", "object": "MONDO:0009520", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:6157502", "PMID:11129331", "PMID:28583327", "PMID:15505778", "PMID:25557019", "PMID:23705938", "PMID:1886403", "PMID:12072887", "PMID:19893767"], "original_subject": "HMDB:HMDB0000062", "original_object": "OMIM:246450"}
{"subject": "REACT:R-HSA-4341669", "predicate": "biolink:has_input", "object": "CHEBI:15377", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-4341669", "original_object": "CHEBI:15377"}
{"object": "GO:0019164", "predicate": "biolink:has_part", "subject": "GO:0006086", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0019164", "original_subject": "GO:0006086"}
{"subject": "UBERON:0003008", "predicate": "biolink:temporally_related_to", "object": "GO:0016331", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003008", "original_object": "GO:0016331"}
{"subject": "GO:1902200", "predicate": "biolink:has_output", "object": "CHEBI:57344", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1902200", "original_object": "CHEBI:57344"}
{"subject": "NCBIGene:5743", "predicate": "biolink:affects", "object": "CHEBI:44185", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMID:32254955"], "tmkp_confidence_score": 0.99970764, "sentences": "And, in vivo, multifunctional Pd-Cys@MTX@RGD effectively inhibited the symptoms of RA by inhibiting the expression of pro-inflammatory cytokines (TNF-?,COX-2).|NA", "tmkp_ids": ["tmkp:cf42a86f60d5dedb6570f49869d9f1180dce206785396a07afacebc174362d8f"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "decreased", "original_subject": "UniProtKB:P35354", "original_object": "DRUGBANK:DB00563"}
{"subject": "GO:0140167", "predicate": "biolink:has_output", "object": "GO:0035363", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0140167", "original_object": "GO:0035363"}
{"object": "EMAPA:27105", "predicate": "biolink:has_part", "subject": "EMAPA:27095", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "EMAPA:27105", "original_subject": "EMAPA:27095"}
{"subject": "UBERON:0011628", "predicate": "biolink:related_to", "object": "UBERON:0010313", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0011628", "original_object": "UBERON:0010313"}
{"subject": "NCBIGene:25903", "predicate": "biolink:genetically_associated_with", "object": "UMLS:C0023893", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:24558", "original_object": "UMLS:C0023893"}
{"object": "GO:0008033", "predicate": "biolink:occurs_in", "subject": "REACT:R-BTA-6782315", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0008033", "original_subject": "REACT:R-BTA-6782315"}
{"subject": "UBERON:0010404", "predicate": "biolink:related_to", "object": "GO:0050877", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010404", "original_object": "GO:0050877"}
{"subject": "UMLS:C5708041", "predicate": "biolink:affects", "object": "UMLS:C0039195", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C188801", "original_object": "NCIT:C12543"}
{"subject": "UNII:9430ZR8ZAN", "predicate": "biolink:causes", "object": "MONDO:0005492", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB06705", "original_object": "UMLS:C0042109"}
{"subject": "UMLS:C1711180", "predicate": "biolink:subclass_of", "object": "UMLS:C1521913", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C44522", "original_object": "NCIT:C13432"}
{"subject": "MONDO:1010755", "predicate": "biolink:in_taxon", "object": "NCBITaxon:9913", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:1010755", "original_object": "NCBITaxon:9913"}
{"subject": "UBERON:0003700", "predicate": "biolink:located_in", "object": "UBERON:0000165", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003700", "original_object": "UBERON:0000165"}
{"subject": "UBERON:0011255", "predicate": "biolink:overlaps", "object": "GO:0005622", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0011255", "original_object": "GO:0005622"}
{"subject": "CHEBI:16070", "predicate": "biolink:related_to", "object": "CHEBI:17924", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16070", "original_object": "CHEBI:17924"}
{"subject": "CHEBI:52033", "predicate": "biolink:has_part", "object": "CHEBI:52820", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:52033", "original_object": "CHEBI:52820"}
{"subject": "REACT:R-HSA-1222512", "predicate": "biolink:has_input", "object": "CHEBI:36144", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-1222512", "original_object": "CHEBI:36144"}
{"subject": "PANTHER.FAMILY:PTHR11801:SF18", "predicate": "biolink:actively_involved_in", "object": "GO:0007259", "primary_knowledge_source": "infores:panther", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR11801:SF18", "original_object": "GO:0007259"}
{"object": "GO:0007091", "predicate": "biolink:occurs_in", "subject": "REACT:R-HSA-163010", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-HSA-68881", "original_subject": "REACT:R-HSA-163010"}
{"subject": "CHEBI:50931", "predicate": "biolink:similar_to", "object": "CHEBI:135295", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB01239", "original_object": "DRUGBANK:DB01511"}
{"subject": "CL:0000613", "predicate": "biolink:related_to", "object": "PR:000002065", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000613", "original_object": "PR:000002065"}
{"subject": "GO:0047620", "predicate": "biolink:related_to", "object": "GO:0047620", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0047620", "original_object": "GO:0047620"}
{"subject": "MONDO:0006789", "predicate": "biolink:subclass_of", "object": "NCIT:C81326", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C113755", "original_object": "NCIT:C81326"}
{"subject": "NCBIGene:9855", "predicate": "biolink:affects", "object": "GO:0016601", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:12351724"], "original_subject": "UniProtKB:O94887", "original_object": "GO:0016601"}
{"subject": "CL:4023113", "predicate": "biolink:overlaps", "object": "GO:0045202", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4023113", "original_object": "GO:0045202"}
{"subject": "GO:0062078", "predicate": "biolink:has_input", "object": "GO:0033596", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0062078", "original_object": "GO:0033596"}
{"subject": "PUBCHEM.COMPOUND:44422696", "predicate": "biolink:related_to", "object": "NCBIGene:1132", "affinity_parameter": "pKi", "supporting_affinities": [4.34], "publications": ["PMID:18077164"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 4.34, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:44422696", "original_object": "UniProtKB:P08173"}
{"subject": "HP:0002098", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002046", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00822_MESH_D000437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002098", "original_object": "MESH:D000437"}
{"subject": "NCBIGene:213", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0010604", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5269444", "PMC:5269444", "PMC:7467451", "PMC:7467451", "PMC:8362221"], "tmkp_confidence_score": 0.7510764686879398, "sentences": "These results demonstrate improved correction of hemophilia B using AAV vectors pre-incubated with HSA, and also suggest possible utilization of this formulation to increase efficacy at lower vector doses for the treatment of hemophilia and other diseases.|NA|Improved phenotypic correction of hemophilia B using human albumin to enhance AAV vector transduction|NA|An extended half-life fusion protein linking recombinant FIX (rFIX) with human albumin (rIX-FP) has been developed for the treatment of patients with haemophilia B and is indicated for dosing up to every 14?days.|NA|This study looked at the use of an extended half-life fusion protein linking recombinant FIX (rFIX) with human albumin (rIX-FP), which was designed to allow longer dosing intervals, in patients with haemophilia B in Italy, Belgium and the UK, and compared this with the patients? previous FIX product.|NA|The short half?life of coagulation factor IX (FIX) for haemophilia B (HB) therapy has been prolonged through fusion with human serum albumin (HSA), which drives the neonatal Fc receptor (FcRn)?mediated recycling of the chimera.|NA", "tmkp_ids": ["tmkp:ea6077357b87d83e75591a3f05a9b23dfbd36bd2bef7d5d6b1ed1b6f7f413490", "tmkp:c5fe9040a43a41e353ab8e1292a19f77db8d07a1965b97337c673d0bf92e545d", "tmkp:6d51739a0b3e8896689128e28e893c10dbce882dc01c65e0b1eb8384f65239aa", "tmkp:808d4496d401416444223e8287801d6655880b5113d86b2dae8910afa8dde67c", "tmkp:aaea7629bde1e50035ac706ae62a60850a01f58825ec1e574a59f55a85c95925"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00062", "original_object": "MONDO:0010604"}
{"subject": "CHEBI:25944", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005093", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:11665844", "PMID:15858460"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010575", "original_object": "MESH:D012871"}
{"subject": "CHEBI:17303", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0002400", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5920688", "PMC:5678813", "PMC:6585085", "PMC:5920688"], "tmkp_confidence_score": 0.7046765696011439, "sentences": "Anti-inflammatory effects of intra-articular administration of morphine in horses with experimentally induced synovitis|NA|Intra-articular administration of morphine reduced nucleated cell count in synovial fluid of chronic arthritis patients and serum amyloid A and total protein levels in horses with experimentally-induced synovitis.|NA|Morphine has anti-inflammatory properties and decreased ST and JC in equine synovitis.|NA|Effects of intraarticular ropivacaine and morphine on lipopolysaccharide-induced synovitis in horses|NA", "tmkp_ids": ["tmkp:31bdc9f5f01c7a507667359ca27ee103a7409ee5df0a254a913e43cbb594adce", "tmkp:5515019d25bdb4b6f07921ffa9581544a7e23143bdacfa9f5690de424356bf0e", "tmkp:587411d4769ba0b2b65502d496149dae3d5fe82d56780e1aa61a22e931455273", "tmkp:af021439182a0d6271f7a4881e1613ef2bb3d4c0d2cd07109f693444b7597fe9"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00295", "original_object": "MONDO:0002400"}
{"subject": "GO:0009532", "predicate": "biolink:in_taxon", "object": "NCBITaxon:131567", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009532", "original_object": "NCBITaxon:131567"}
{"subject": "CHEBI:27882", "predicate": "biolink:similar_to", "object": "CHEBI:32241", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB01394", "original_object": "DRUGBANK:DB08811"}
{"subject": "UNII:C3574QBZ3Y", "predicate": "biolink:contributes_to", "object": "EFO:0009426", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:24503009"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C028007", "original_object": "MESH:D009336"}
{"subject": "GO:0015765", "predicate": "biolink:has_input", "object": "CHEBI:60982", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015765", "original_object": "CHEBI:60982"}
{"subject": "UNII:Q5EN532NE7", "predicate": "biolink:preventative_for_condition", "object": "GO:0090592", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01280_MESH_D054218_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C022206", "original_object": "GO:0090592"}
{"subject": "CHEBI:119915", "predicate": "biolink:causes", "object": "UMLS:C0235146", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00813", "original_object": "UMLS:C0235146"}
{"subject": "GO:0030073", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002909", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00222_MESH_D003924_1", "DB00672_MESH_D003924_1", "DB00731_MESH_D003924_1", "DB00839_MESH_D003924_1", "DB01016_MESH_D003924_1", "DB01120_MESH_D003924_1", "DB01124_MESH_D003924_1", "DB01289_MESH_D003924_1", "DB08962_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030073", "original_object": "HP:0003074"}
{"subject": "UBERON:0009975", "predicate": "biolink:related_to", "object": "GO:0050877", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0009975", "original_object": "GO:0050877"}
{"subject": "MONDO:0002367", "predicate": "biolink:similar_to", "object": "MONDO:0005089", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["MEDLINE cooccurrence"], "original_subject": "DOID:263", "original_object": "DOID:1115"}
{"subject": "UBERON:0002233", "predicate": "biolink:related_to", "object": "UBERON:0002276", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002233", "original_object": "UBERON:0002276"}
{"subject": "MONDO:0100096", "predicate": "biolink:has_part", "object": "NCBIGene:59272", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "complex_context": ["S1 trimer:ACE2:S2 trimer", "S1:ACE2", "S3:M:E:encapsidated  SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs", "S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2", "Spike trimer:ACE2"], "original_subject": "DOID:0080600", "original_object": "UniProtKB:Q9BYF1"}
{"subject": "UMLS:C0087048", "predicate": "biolink:has_part", "object": "NCIT:C25793", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C26426", "original_object": "NCIT:C25793"}
{"subject": "NCBIGene:79001", "predicate": "biolink:decreases_sensitivity_to", "object": "CHEBI:50249", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "NCBITaxon:10116", "publications": ["PMID:19890940"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:79001", "original_object": "MESH:D000925"}
{"subject": "CHEBI:3398", "predicate": "biolink:contraindicated_in", "object": "HP:0200119", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:499", "original_object": "UMLS:C0267797"}
{"subject": "ComplexPortal:CPX-4750", "predicate": "biolink:catalyzes", "object": "GO:0005085", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_agent", "publications": ["PMID:27066478"], "original_subject": "ComplexPortal:CPX-4750", "original_object": "GO:0005085"}
{"subject": "CHEBI:91083", "predicate": "biolink:related_to", "object": "CHEBI:17920", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:91083", "original_object": "CHEBI:17920"}
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{"subject": "CHEBI:135666", "predicate": "biolink:has_metabolite", "object": "UNII:2KUZ32F7NT", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01349_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C086167", "original_object": "MESH:C415846"}
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{"subject": "GO:0000146", "predicate": "biolink:overlaps", "object": "GO:0140657", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000146", "original_object": "GO:0140657"}
{"subject": "CHEBI:86743", "predicate": "biolink:related_to", "object": "CHEBI:17987", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:86743", "original_object": "CHEBI:17987"}
{"subject": "NCBIGene:55698", "predicate": "biolink:affects", "object": "GO:0034446", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:23209302"], "original_subject": "UniProtKB:Q96JH8", "original_object": "GO:0034446"}
{"subject": "NCBIGene:37415", "predicate": "biolink:increases_sensitivity_to", "object": "CHEBI:28786", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "NCBITaxon:7227", "publications": ["PMID:17344383"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:37415", "original_object": "MESH:D010269"}
{"subject": "CHEBI:61369", "predicate": "biolink:has_part", "object": "CHEBI:53205", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:61369", "original_object": "CHEBI:53205"}
{"subject": "UBERON:3000036", "predicate": "biolink:overlaps", "object": "UBERON:0003128", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:3000036", "original_object": "UBERON:0003128"}
{"subject": "CHEBI:16236", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:1557", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["DrugBank (enzyme)"], "original_subject": "DRUGBANK:DB00898", "original_object": "NCBIGene:1557"}
{"subject": "UBERON:0006669", "predicate": "biolink:overlaps", "object": "UBERON:0004537", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0006669", "original_object": "UBERON:0004537"}
{"subject": "NCBIGene:10568", "predicate": "biolink:affects", "object": "MESH:D001149", "primary_knowledge_source": "infores:ctd", "description": "increases uptake of", "taxon": "NCBITaxon:10090", "publications": ["PMID:20510259"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:10568", "original_object": "MESH:D001149", "object_aspect_qualifier": "uptake", "object_direction_qualifier": "increased", "qualified_predicate": "biolink:causes"}
{"subject": "CHEBI:50275", "predicate": "biolink:applied_to_treat", "object": "UMLS:C0041909", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1055", "original_object": "UMLS:C0041909"}
{"subject": "CHEBI:81777", "predicate": "biolink:subclass_of", "object": "CHEBI:60911", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:81777", "original_object": "CHEBI:60911"}
{"subject": "GO:0090256", "predicate": "biolink:causes", "object": "GO:0007472", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0090256", "original_object": "GO:0007472"}
{"subject": "MESH:D052638", "predicate": "biolink:contributes_to", "object": "HP:0001667", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:28415675"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D052638", "original_object": "MESH:D017380"}
{"object": "UBERON:0009191", "predicate": "biolink:has_part", "subject": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0009191", "original_subject": "NCBITaxon:6072"}
{"subject": "CHEBI:6402", "predicate": "biolink:causes", "object": "UMLS:C0151754", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01097", "original_object": "UMLS:C0151754"}
{"subject": "CHEBI:31387", "predicate": "biolink:has_part", "object": "CHEBI:59224", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:31387", "original_object": "CHEBI:59224"}
{"subject": "CHEBI:52446", "predicate": "biolink:has_part", "object": "CHEBI:52527", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:52446", "original_object": "CHEBI:52527"}
{"subject": "ComplexPortal:CPX-5001", "predicate": "biolink:located_in", "object": "GO:0005929", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_agent", "publications": ["PMID:27158779"], "original_subject": "ComplexPortal:CPX-5001", "original_object": "GO:0005929"}
{"subject": "GO:0018104", "predicate": "biolink:contributes_to", "object": "GO:0005618", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01333_MESH_D012141_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0018104", "original_object": "GO:0005618"}
{"subject": "NCBIGene:540", "predicate": "biolink:decreases_sensitivity_to", "object": "UNII:19PPS85F9H", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "NCBITaxon:10090", "publications": ["PMID:20005242"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:540", "original_object": "MESH:C103100"}
{"subject": "MP:0001916", "predicate": "biolink:affects", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MP:0001916", "original_object": "NCBITaxon:6072"}
{"subject": "CHEBI:2668", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:64064", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:2162", "original_object": "PUBCHEM.COMPOUND:5152"}
{"subject": "GO:1901696", "predicate": "biolink:has_output", "object": "CHEBI:67194", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1901696", "original_object": "CHEBI:67194"}
{"subject": "CHEBI:131804", "predicate": "biolink:related_to", "object": "CHEBI:131805", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:131804", "original_object": "CHEBI:131805"}
{"subject": "MONDO:0019145", "predicate": "biolink:has_participant", "object": "GO:0004252", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0019145", "original_object": "GO:0004252"}
{"subject": "MESH:C515928", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0012534", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:16982702"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C515928", "original_object": "MESH:D006930"}
{"subject": "GO:0038088", "predicate": "biolink:subclass_of", "object": "GO:0035791", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0038088", "original_object": "GO:0035791"}
{"subject": "GO:0008900", "predicate": "biolink:positively_correlated_with", "object": "GO:0001696", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00736_MESH_D004942_1", "DB00736_MESH_D010437_1", "DB00736_MESH_D015043_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008900", "original_object": "GO:0001696"}
{"subject": "MONDO:0044784", "predicate": "biolink:related_to", "object": "NCIT:C9478", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C6577", "original_object": "NCIT:C9478"}
{"subject": "GO:0008217", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0005044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06762_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008217", "original_object": "MESH:D006973"}
{"subject": "MONDO:0017791", "predicate": "biolink:associated_with", "object": "MONDO:0002933", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0017791", "original_object": "HP:0011001"}
{"subject": "MESH:D062065", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005093", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:18005315"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D062065", "original_object": "MESH:D012871"}
{"subject": "GO:0043704", "predicate": "biolink:related_to", "object": "CL:0000210", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0043704", "original_object": "CL:0000210"}
{"subject": "MP:0005186", "predicate": "biolink:affects", "object": "CHEBI:17026", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MP:0005186", "original_object": "CHEBI:17026"}
{"subject": "GO:0019627", "predicate": "biolink:has_participant", "object": "CHEBI:16199", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019627", "original_object": "CHEBI:16199"}
{"subject": "CL:0003012", "predicate": "biolink:overlaps", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0003012", "original_object": "NCBITaxon:6072"}
{"subject": "CHEBI:17234", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005148", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00284_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17234", "original_object": "MESH:D003924"}
{"subject": "MONDO:0005224", "predicate": "biolink:affects", "object": "UMLS:C1514037", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C3249", "original_object": "NCIT:C37179"}
{"subject": "UMLS:C0041485", "predicate": "biolink:similar_to", "object": "CHEBI:15765", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00135", "original_object": "DRUGBANK:DB01235"}
{"subject": "CHEBI:16236", "predicate": "biolink:contributes_to", "object": "HP:0001692", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9070688", "PMC:5903584", "PMC:5903584", "PMC:8615757", "PMC:9191232"], "tmkp_confidence_score": 0.7676621891032429, "sentences": "Previous studies using animal models have demonstrated how tobacco and alcohol are associated with atrial arrhythmia formation, and while specific literature describing the relationship between tobacco and AFL is limited, alcohol has been associated with AFL formation in humans.|NA|Our studies demonstrate that binge alcohol exposure activates JNK2 in atria, which then drives CaMKII activation, prompting aberrant Ca2+ waves and, thus, enhanced susceptibility to atrial arrhythmia.|NA|Representative electrogram traces show alcohol-exposed mice developed atrial arrhythmia following 30 s of pacing at 8 Hz (3? diastolic threshold) (Figure 3A1), while sham control animals immediately returned to sinus rhythm (Figure 3A2).|NA|Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia|NA|Role of stress kinase JNK in binge alcohol-evoked atrial arrhythmia|NA", "tmkp_ids": ["tmkp:95c2d34787efc1fbdf256e134f20316753f5cecb114e500754c219016a7eceac", "tmkp:13158bdc0cc7077b675695f4c49cf0ded4672ebfb8ffed9a21d8d52639a8895a", "tmkp:5f005f81cd0b1abc9fd389da1fa5ee2e6f002ad5f5123ce46080391708f1916f", "tmkp:ae599fa08483d94294f4eb137bc21e3016c494a10811a2859940b02451cfad4c", "tmkp:b1f46742a75edfa17ed33fe8501f0f4cb4d37079d8d092f06440fb168ee32cbc"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00898", "original_object": "HP:0001692"}
{"object": "MONDO:0019087", "predicate": "biolink:causes", "subject": "UBERON:0002394", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0019087", "original_subject": "UBERON:0002394"}
{"subject": "UBERON:0001460", "predicate": "biolink:coexists_with", "object": "UBERON:0001467", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001460", "original_object": "UBERON:0001467"}
{"subject": "HP:0012844", "predicate": "biolink:has_phenotype", "object": "MONDO:0007758", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C4113", "original_object": "NCIT:C35541"}
{"subject": "CHEBI:39332", "predicate": "biolink:subclass_of", "object": "CHEBI:60915", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:39332", "original_object": "CHEBI:60915"}
{"subject": "GO:0060638", "predicate": "biolink:occurs_in", "object": "CL:0008019", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060638", "original_object": "CL:0008019"}
{"subject": "GO:0140619", "predicate": "biolink:regulates", "object": "GO:0000150", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0140619", "original_object": "GO:0000150", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "CHEBI:746921", "predicate": "biolink:subclass_of", "object": "PR:000000001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:746921", "original_object": "PR:000000001"}
{"subject": "GO:0048731", "predicate": "biolink:has_output", "object": "UBERON:0000467", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0048731", "original_object": "UBERON:0000467"}
{"subject": "CHEBI:63556", "predicate": "biolink:has_part", "object": "CHEBI:53621", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:63556", "original_object": "CHEBI:53621"}
{"subject": "CHEBI:89510", "predicate": "biolink:correlated_with", "object": "NCBIGene:2688", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:8729530", "PMID:9640412", "PMID:16384844"], "original_subject": "HMDB:HMDB0000569", "original_object": "OMIM:139250"}
{"subject": "UMLS:C0042313", "predicate": "biolink:disrupts", "object": "CHEBI:16576", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00512_MESH_D000071074_1", "DB00512_MESH_D004697_1", "DB00512_MESH_D004761_1", "DB00512_MESH_D011023_1", "DB00512_MESH_D013203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014640", "original_object": "CHEBI:16576"}
{"subject": "GO:0036398", "predicate": "biolink:overlaps", "object": "GO:0005886", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0036398", "original_object": "GO:0005886"}
{"subject": "CHEBI:16236", "predicate": "biolink:has_adverse_event", "object": "HP:0005972", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 29.881, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1076", "original_object": "MEDDRA:10038661"}
{"subject": "UBERON:6001649", "predicate": "biolink:contributes_to", "object": "UBERON:0003142", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "FBbt:00001649", "original_object": "UBERON:0003142"}
{"subject": "NCBIGene:6863", "predicate": "biolink:negatively_correlated_with", "object": "GO:0098818", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00454_MESH_D010146_1", "DB00454_MESH_D048949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P20366", "original_object": "GO:0098818"}
{"subject": "GO:0006270", "predicate": "biolink:precedes", "object": "REACT:R-PFA-68962", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006270", "original_object": "REACT:R-PFA-68962"}
{"subject": "UNII:5M691HL4BO", "predicate": "biolink:has_adverse_event", "object": "HP:0025143", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 417.645, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4880", "original_object": "MEDDRA:10008531"}
{"subject": "CHEBI:17688", "predicate": "biolink:affects", "object": "MONDO:0005002", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:30576219"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D009538", "original_object": "MESH:D029424"}
{"subject": "CHEBI:61435", "predicate": "biolink:subclass_of", "object": "CHEBI:60027", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:61435", "original_object": "CHEBI:60027"}
{"subject": "CHEBI:3385", "predicate": "biolink:affects", "object": "HGNC.FAMILY:180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00411_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D002217", "original_object": "HGNC.FAMILY:180"}
{"subject": "NCBIGene:6910", "predicate": "biolink:acts_upstream_of", "object": "GO:1901846", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:15289437"], "original_subject": "UniProtKB:Q99593", "original_object": "GO:1901846"}
{"subject": "CHEBI:6485", "predicate": "biolink:causes", "object": "UMLS:C0022107", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01583", "original_object": "UMLS:C0022107"}
{"subject": "MONDO:0001501", "predicate": "biolink:affects", "object": "UBERON:0003693", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C4832", "original_object": "NCIT:C12298"}
{"subject": "GO:0120111", "predicate": "biolink:related_to", "object": "GO:0019226", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0120111", "original_object": "GO:0019226"}
{"subject": "GO:0005983", "predicate": "biolink:affects", "object": "CHEBI:17234", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00284_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0005983", "original_object": "CHEBI:17234"}
{"subject": "NCBIGene:401024", "predicate": "biolink:acts_upstream_of_or_within_positive_effect", "object": "GO:0007288", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:30137358", "PMID:30745215"], "original_subject": "UniProtKB:Q5CZC0", "original_object": "GO:0007288"}
{"subject": "MONDO:0001898", "predicate": "biolink:affects", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000610", "original_object": "NCBITaxon:6072"}
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{"subject": "CHEBI:109077", "predicate": "biolink:subclass_of", "object": "CHEBI:25562", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:109077", "original_object": "CHEBI:25562"}
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{"subject": "NCBIGene:7453", "predicate": "biolink:affects", "object": "CHEBI:29888", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P23381", "original_object": "HMDB:HMDB0000250", "object_aspect_qualifier": "abundance"}
{"subject": "UBERON:2007045", "predicate": "biolink:develops_from", "object": "UBERON:0009615", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:2007045", "original_object": "UBERON:0009615"}
{"subject": "UMLS:C0009315", "predicate": "biolink:causes", "object": "UMLS:C0241729", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01111", "original_object": "UMLS:C0241729"}
{"subject": "GO:0022016", "predicate": "biolink:occurs_in", "object": "UBERON:0000955", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0022016", "original_object": "UBERON:0000955"}
{"subject": "MP:0010802", "predicate": "biolink:affects", "object": "CL:1001516", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MP:0010802", "original_object": "CL:1001516"}
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{"subject": "NCBIGene:131", "predicate": "biolink:regulates", "object": "CHEBI:16236", "primary_knowledge_source": "infores:metabolomics_workbench", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "HGNC:256", "original_object": "PUBCHEM.COMPOUND:702"}
{"subject": "GO:2001082", "predicate": "biolink:has_input", "object": "CHEBI:15443", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:2001082", "original_object": "CHEBI:15443"}
{"subject": "GO:0034188", "predicate": "biolink:precedes", "object": "GO:0009987", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0034188", "original_object": "GO:0009987"}
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{"subject": "CHEBI:62968", "predicate": "biolink:subclass_of", "object": "CHEBI:17234", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:62968", "original_object": "CHEBI:18246"}
{"subject": "UNII:SE2KH7T06F", "predicate": "biolink:has_adverse_event", "object": "MONDO:0005002", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 49.441, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4979", "original_object": "MEDDRA:10009033"}
{"subject": "CHEBI:76358", "predicate": "biolink:has_part", "object": "CHEBI:76358", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:76359", "original_object": "CHEBI:76358"}
{"subject": "NCBIGene:4094", "predicate": "biolink:located_in", "object": "CL:0002038", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:O75444", "original_object": "CL:0002038"}
{"subject": "GO:0015720", "predicate": "biolink:has_input", "object": "CHEBI:15676", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015720", "original_object": "CHEBI:15676"}
{"object": "GO:0030876", "predicate": "biolink:has_participant", "subject": "GO:0071345", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0030876", "original_subject": "GO:0071345"}
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{"subject": "CHEBI:16526", "predicate": "biolink:correlated_with", "object": "HP:0001950", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00819_MESH_D000532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002245", "original_object": "HP:0001950"}
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{"subject": "UBERON:6001658", "predicate": "biolink:develops_from", "object": "UBERON:6001781", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "FBbt:00001658", "original_object": "FBbt:00001781"}
{"subject": "CHEBI:33853", "predicate": "biolink:positively_correlated_with", "object": "EFO:0004344", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:18709157", "PMID:21900077", "PMID:25061923"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010636", "original_object": "MESH:D001724"}
{"subject": "CHEBI:73306", "predicate": "biolink:has_part", "object": "CHEBI:53118", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:73306", "original_object": "CHEBI:53118"}
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{"subject": "NCBIGene:6580", "predicate": "biolink:located_in", "object": "UBERON:0008404", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:O15245", "original_object": "UBERON:0008404"}
{"subject": "CL:0000771", "predicate": "biolink:related_to", "object": "GO:0004930", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000771", "original_object": "GO:0004930"}
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{"subject": "UMLS:C0087071", "predicate": "biolink:biomarker_for", "object": "MONDO:0005072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C17470", "original_object": "NCIT:C3270"}
{"subject": "NCBIGene:5743", "predicate": "biolink:target_for", "object": "HP:0002315", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09213_MESH_D006261_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P35354", "original_object": "MESH:D006261"}
{"subject": "CHEBI:7494", "predicate": "biolink:causes", "object": "UMLS:C1142135", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01149", "original_object": "UMLS:C1142135"}
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{"subject": "MP:0008820", "predicate": "biolink:affects", "object": "CHEBI:27226", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MP:0008820", "original_object": "CHEBI:27226"}
{"subject": "NCBIGene:3359", "predicate": "biolink:affects", "object": "CHEBI:16236", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P46098", "original_object": "HMDB:HMDB0000108", "object_aspect_qualifier": "abundance"}
{"subject": "GO:0086016", "predicate": "biolink:occurs_in", "object": "UBERON:0002085", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0086016", "original_object": "UBERON:0002085"}
{"subject": "NCBIGene:150", "predicate": "biolink:correlated_with", "object": "MONDO:0002009", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06148_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08913", "original_object": "MESH:D003865"}
{"subject": "UNII:DJX4AL4ENX", "predicate": "biolink:positively_correlated_with", "object": "GO:0035861", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01262_MESH_D015470_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PUBCHEM.COMPOUND:126357", "original_object": "GO:0035861"}
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{"subject": "CHEBI:17303", "predicate": "biolink:causes", "object": "MONDO:0002076", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00295", "original_object": "UMLS:C0032326"}
{"subject": "UBERON:0010743", "predicate": "biolink:overlaps", "object": "GO:0140152", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010743", "original_object": "GO:0140152"}
{"subject": "UBERON:0006267", "predicate": "biolink:develops_from", "object": "UBERON:0006268", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0006267", "original_object": "UBERON:0006268"}
{"subject": "UNII:VY778IXU5T", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:51701", "primary_knowledge_source": "infores:pharos", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 7.62, "affinity_parameter": "pKd", "publications": ["PMID:29191878"], "original_subject": "CHEMBL.COMPOUND:CHEMBL3688339", "original_object": "HGNC:29858"}
{"subject": "NCBIGene:3959", "predicate": "biolink:biomarker_for", "object": "UMLS:C0278504", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C26351", "original_object": "NCIT:C6671"}
{"subject": "GO:0036098", "predicate": "biolink:affects", "object": "CL:0000016", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0036098", "original_object": "CL:0000016"}
{"subject": "UMLS:C0065374", "predicate": "biolink:treats", "object": "MONDO:0005100", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00722", "original_object": "DOID:418"}
{"subject": "UNII:3QJA87N40S", "predicate": "biolink:causes", "object": "UMLS:C0858581", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB08884", "original_object": "UMLS:C0858581"}
{"subject": "GO:0006874", "predicate": "biolink:positively_correlated_with", "object": "GO:0001503", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00481_MESH_D015663_1", "DB06401_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006874", "original_object": "GO:0001503"}
{"subject": "UBERON:0008877", "predicate": "biolink:subclass_of", "object": "GO:0005604", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0008877", "original_object": "UBERON:0005769"}
{"object": "NCBIGene:4986", "predicate": "biolink:has_participant", "subject": "GO:0038003", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01183_MESH_D009293_1", "DB01183_MESH_D010146_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P41145", "original_subject": "GO:0038003"}
{"subject": "MONDO:0005311", "predicate": "biolink:contributes_to", "object": "HP:0001681", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01076_MESH_D000787_1", "DB09069_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002621", "original_object": "MESH:D000787"}
{"subject": "CHEBI:3160", "predicate": "biolink:has_adverse_event", "object": "HP:0001945", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 200.792, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5368", "original_object": "MEDDRA:10037660"}
{"subject": "GO:0031569", "predicate": "biolink:related_to", "object": "GO:0051319", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0031569", "original_object": "GO:0051319"}
{"subject": "UMLS:C0003995", "predicate": "biolink:similar_to", "object": "UMLS:C0003765", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00174", "original_object": "DRUGBANK:DB00125"}
{"subject": "CHEBI:42355", "predicate": "biolink:affects", "object": "MESH:D012338", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00199_MESH_D008088_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D004917", "original_object": "MESH:D012338"}
{"subject": "MONDO:0001531", "predicate": "biolink:has_part", "object": "CHEBI:29108", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "complex_context": ["ANO6 variant:Ca2+"], "original_subject": "DOID:1247", "original_object": "CHEBI:29108"}
{"subject": "GO:1904176", "predicate": "biolink:capable_of", "object": "GO:0018835", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1904176", "original_object": "GO:0018835"}
{"subject": "GO:0080145", "predicate": "biolink:related_to", "object": "CHEBI:15356", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0080145", "original_object": "CHEBI:35237"}
{"subject": "PR:000044456", "predicate": "biolink:derives_from", "object": "PR:000044455", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:000044456", "original_object": "PR:000044455"}
{"subject": "CHEBI:3638", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:30413", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00608_MESH_D016778_1", "DB00608_MESH_D016780_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002738", "original_object": "MESH:D006418"}
{"subject": "HP:0012514", "predicate": "biolink:correlated_with", "object": "MONDO:0005391", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08872_MESH_D012148_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012514", "original_object": "MESH:D012148"}
{"subject": "CHEBI:83611", "predicate": "biolink:related_to", "object": "CHEBI:83604", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:83611", "original_object": "CHEBI:83604"}
{"subject": "CHEBI:6078", "predicate": "biolink:has_part", "object": "CHEBI:63943", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:6078", "original_object": "CHEBI:63943"}
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{"subject": "UNII:80EHD8I43D", "predicate": "biolink:treats", "object": "UMLS:C0152030", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4998", "original_object": "UMLS:C0152030"}
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{"subject": "GO:0071953", "predicate": "biolink:subclass_of", "object": "UBERON:0002384", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002521", "original_object": "UBERON:0002384"}
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{"subject": "CHEBI:15355", "predicate": "biolink:positively_correlated_with", "object": "HP:0000616", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01057_MESH_D000080362_1", "DB01057_MESH_D005901_1", "DB01057_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000109", "original_object": "HP:0000616"}
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{"subject": "CHEBI:25029", "predicate": "biolink:positively_correlated_with", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:25029", "original_object": "GO:0006954"}
{"subject": "NCBIGene:11180", "predicate": "biolink:acts_upstream_of_negative_effect", "object": "GO:0070314", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:17216128"], "original_subject": "UniProtKB:Q9NNW5", "original_object": "GO:0070314"}
{"subject": "HP:0012531", "predicate": "biolink:manifestation_of", "object": "HP:0003418", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01744_MESH_D001416_1", "DB06774_MESH_D001416_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012531", "original_object": "MESH:D001416"}
{"subject": "GO:0009051", "predicate": "biolink:temporally_related_to", "object": "GO:0004616", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009051", "original_object": "GO:0004616"}
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{"subject": "UMLS:C0535906", "predicate": "biolink:decreases_sensitivity_to", "object": "NCBIGene:7349", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "NCBITaxon:10116", "publications": ["PMID:20237592"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C104416", "original_object": "NCBIGENE:7349"}
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{"subject": "UBERON:8600026", "predicate": "biolink:composed_primarily_of", "object": "UBERON:0007106", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:8600026", "original_object": "UBERON:0007106"}
{"subject": "UBERON:6006032", "predicate": "biolink:contributes_to", "object": "UBERON:0007023", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "FBbt:00006032", "original_object": "FBbt:00003004"}
{"subject": "GO:0042311", "predicate": "biolink:contributes_to", "object": "HP:0010783", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13158_MESH_D003876_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042311", "original_object": "HP:0010783"}
{"subject": "MP:0010320", "predicate": "biolink:affects", "object": "MP:0002006", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MP:0010320", "original_object": "MP:0002006"}
{"object": "NCBIGene:2488", "predicate": "biolink:gene_product_of", "subject": "CHEBI:81569", "primary_knowledge_source": "infores:gtopdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HGNC:3964", "original_subject": "GTOPDB:1157"}
{"subject": "GO:0036480", "predicate": "biolink:occurs_in", "object": "UBERON:0001016", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0036480", "original_object": "UBERON:0001016"}
{"subject": "CHEBI:30956", "predicate": "biolink:affects", "object": "EFO:0004344", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:22225821"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D014238", "original_object": "MESH:D001724"}
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{"subject": "UniProtKB:Q05486", "predicate": "biolink:capable_of", "object": "GO:0003964", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01265_MESH_D019694_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q05486", "original_object": "GO:0003964"}
{"subject": "CHEBI:181423", "predicate": "biolink:subclass_of", "object": "CHEBI:27300", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:181423", "original_object": "CHEBI:27300"}
{"subject": "UMLS:C0009315", "predicate": "biolink:disrupts", "object": "GO:0061701", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01111_MESH_D004927_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C004691", "original_object": "GO:0061701"}
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{"subject": "UBERON:0006650", "predicate": "biolink:overlaps", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0006650", "original_object": "NCBITaxon:6072"}
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{"subject": "HGNC.FAMILY:1927", "predicate": "biolink:contributes_to", "object": "MONDO:0005412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00338_MESH_D004381_1", "DB00927_MESH_D004381_1", "DB11739_MESH_D004381_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:1927", "original_object": "MESH:D004381"}
{"subject": "HP:0003470", "predicate": "biolink:in_taxon", "object": "NCBITaxon:6252", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00592_MESH_D001196_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0003470", "original_object": "NCBITaxon:6252"}
{"subject": "MESH:D054681", "predicate": "biolink:target_for", "object": "MONDO:0005316", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01190_MESH_D016585_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D054681", "original_object": "MESH:D016585"}
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{"subject": "UBERON:0022320", "predicate": "biolink:composed_primarily_of", "object": "CL:0000598", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0022320", "original_object": "CL:0000598"}
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{"subject": "UBERON:0005777", "predicate": "biolink:capable_of", "object": "GO:0003094", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0005777", "original_object": "GO:0003094"}
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{"subject": "GO:0044476", "predicate": "biolink:causes", "object": "GO:0008332", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0044476", "original_object": "GO:0008332"}
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{"subject": "GO:0033571", "predicate": "biolink:has_input", "object": "PR:000009978", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0033571", "original_object": "PR:000009978"}
{"subject": "CHEBI:90705", "predicate": "biolink:increases_sensitivity_to", "object": "NCBIGene:8743", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "NCBITaxon:9606", "publications": ["PMID:19497411"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C093642", "original_object": "NCBIGENE:8743"}
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{"subject": "CHEBI:5163", "predicate": "biolink:has_metabolite", "object": "UMLS:C0075061", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00492_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D017328", "original_object": "MESH:C046965"}
{"subject": "CHEBI:27953", "predicate": "biolink:has_part", "object": "CHEBI:27953", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:48883", "original_object": "CHEBI:27953"}
{"subject": "HP:0030685", "predicate": "biolink:affects", "object": "NCBIGene:9370", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0030685", "original_object": "PR:Q15848"}
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{"subject": "CHEBI:17303", "predicate": "biolink:causes", "object": "UMLS:C0549249", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00295", "original_object": "UMLS:C0549249"}
{"subject": "CHEBI:45713", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "UBERON:2000006", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:19796711"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000077185", "original_object": "MESH:D015452"}
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{"subject": "GO:1990972", "predicate": "biolink:capable_of", "object": "GO:0007160", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990972", "original_object": "GO:0007160"}
{"subject": "NCBIGene:3569", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0015564", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09036_MESH_D005871_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P05231", "original_object": "MESH:D005871"}
{"subject": "UMLS:C3529561", "predicate": "biolink:chemically_similar_to", "object": "NCBIGene:2157", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09109_MESH_D006467_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C577506", "original_object": "UniProtKB:P00451"}
{"subject": "CHEBI:32297", "predicate": "biolink:regulates", "object": "HGNC.FAMILY:184", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12131_MESH_D003704_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C013983", "original_object": "HGNC.FAMILY:184"}
{"subject": "CHEBI:16236", "predicate": "biolink:correlated_with", "object": "MONDO:0008930", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:3816078", "PMID:16425363", "PMID:10063930", "PMID:6182605", "PMID:6182788", "PMID:24657864", "PMID:21970810", "PMID:27452636"], "original_subject": "HMDB:HMDB0000108", "original_object": "OMIM:212750"}
{"subject": "CHEBI:16991", "predicate": "biolink:occurs_in", "object": "CL:0000084", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01204_MESH_D020529_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004247", "original_object": "CL:0000084"}
{"subject": "CHEBI:16977", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0022650", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4255", "original_object": "UMLS:C0022650"}
{"object": "MONDO:0800386", "predicate": "biolink:causes", "subject": "CHEBI:25703", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0800386", "original_subject": "CHEBI:25703"}
{"subject": "GO:0005246", "predicate": "biolink:causes", "object": "GO:0070588", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005246", "original_object": "GO:0070588"}
{"subject": "CHEBI:16576", "predicate": "biolink:located_in", "object": "GO:0009275", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00512_MESH_D000071074_1", "DB00512_MESH_D004697_1", "DB00512_MESH_D004761_1", "DB00512_MESH_D011023_1", "DB00512_MESH_D013203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16576", "original_object": "GO:0009275"}
{"subject": "GO:0038131", "predicate": "biolink:has_participant", "object": "PR:000000001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0038131", "original_object": "PR:000000001"}
{"subject": "HP:0007906", "predicate": "biolink:contributes_to", "object": "MONDO:0005041", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13165_MESH_D005901_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0007906", "original_object": "MESH:D005901"}
{"subject": "CHEBI:63681", "predicate": "biolink:affects", "object": "GO:0005840", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00358_MESH_D016780_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D015767", "original_object": "GO:0005840"}
{"subject": "NCBIGene:3764", "predicate": "biolink:positively_correlated_with", "object": "GO:0015272", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01289_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q15842", "original_object": "GO:0015272"}
{"subject": "GO:0006694", "predicate": "biolink:affects", "object": "MESH:D000305", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01284_MESH_D000309_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0006694", "original_object": "MESH:D000305"}
{"subject": "GO:0021776", "predicate": "biolink:occurs_in", "object": "UBERON:0001137", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0021776", "original_object": "UBERON:0001137"}
{"subject": "MONDO:0006282", "predicate": "biolink:has_participant", "object": "CL:0002138", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0006282", "original_object": "CL:0002138"}
{"subject": "CHEBI:29321", "predicate": "biolink:has_part", "object": "CHEBI:7596", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:29321", "original_object": "CHEBI:7596"}
{"subject": "GO:0005618", "predicate": "biolink:occurs_in", "object": "NCBITaxon:485", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01602_MESH_D006069_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005618", "original_object": "NCBITaxon:485"}
{"subject": "CHEBI:63580", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR10367", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00811_MESH_D018357_1", "DB00811_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D012254", "original_object": "PANTHER.FAMILY:PTHR10367"}
{"subject": "NCBIGene:627", "predicate": "biolink:regulates", "object": "HP:0012154", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09014_MESH_D001008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P23560", "original_object": "HP:0012154"}
{"subject": "NCBIGene:4130", "predicate": "biolink:positively_correlated_with", "object": "GO:0005874", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01196_MESH_D011471_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P78559", "original_object": "GO:0005874"}
{"subject": "GO:0045851", "predicate": "biolink:disrupts", "object": "NCBITaxon:287", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03166_MESH_D010032_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0045851", "original_object": "NCBITaxon:287"}
{"subject": "CHEBI:3655", "predicate": "biolink:regulates", "object": "GO:0016917", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00356_MESH_D009128_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D002753", "original_object": "GO:0016917"}
{"subject": "MONDO:0010052", "predicate": "biolink:has_participant", "object": "NCBIGene:50511", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0010052", "original_object": "HGNC:18130"}
{"subject": "GO:0001880", "predicate": "biolink:has_input", "object": "UBERON:0003890", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001880", "original_object": "UBERON:0003890"}
{"subject": "NCBIGene:10019", "predicate": "biolink:acts_upstream_of_or_within_negative_effect", "object": "GO:0038163", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:20404132", "PMID:27430239"], "original_subject": "UniProtKB:Q9UQQ2", "original_object": "GO:0038163"}
{"object": "GO:0035554", "predicate": "biolink:has_part", "subject": "GO:0035385", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0035554", "original_subject": "GO:0035385"}
{"subject": "CHEBI:134656", "predicate": "biolink:located_in", "object": "CL:0000096", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:134656", "original_object": "CL:0000096"}
{"object": "GO:0007269", "predicate": "biolink:has_participant", "subject": "HP:0012514", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08872_MESH_D012148_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0007269", "original_subject": "HP:0012514"}
{"subject": "MONDO:0019118", "predicate": "biolink:disrupts", "object": "UBERON:0000060", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0019118", "original_object": "UBERON:0000060"}
{"subject": "GO:0038060", "predicate": "biolink:contributes_to", "object": "GO:0042311", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08931_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0038060", "original_object": "GO:0042311"}
{"subject": "UBERON:0002294", "predicate": "biolink:related_to", "object": "GO:0015106", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002294", "original_object": "GO:0015106"}
{"subject": "CL:4052051", "predicate": "biolink:related_to", "object": "NCBIGene:3682", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4052051", "original_object": "PR:P38570"}
{"subject": "GO:0010467", "predicate": "biolink:regulates", "object": "NCBIGene:1756", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06014_MESH_D020388_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0010467", "original_object": "UniProtKB:P11532"}
{"subject": "CHEBI:17303", "predicate": "biolink:related_to", "object": "CHEBI:58097", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17303", "original_object": "CHEBI:58097"}
{"subject": "CHEBI:9649", "predicate": "biolink:has_metabolite", "object": "CHEBI:141521", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00519_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB00519", "original_object": "MESH:C061095"}
{"subject": "HGNC.FAMILY:245", "predicate": "biolink:affects", "object": "GO:0030432", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00295_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "HGNC.FAMILY:245", "original_object": "GO:0030432"}
{"subject": "UBERON:0000970", "predicate": "biolink:related_to", "object": "CHEBI:30212", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000970", "original_object": "CHEBI:30212"}
{"subject": "UBERON:0000912", "predicate": "biolink:positively_correlated_with", "object": "HP:0031417", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09154_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000912", "original_object": "HP:0031417"}
{"subject": "GO:0051559", "predicate": "biolink:has_output", "object": "CHEBI:61197", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0051559", "original_object": "CHEBI:61197"}
{"subject": "CHEBI:45906", "predicate": "biolink:regulates", "object": "REACT:R-HSA-70171", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04786_MESH_D014353_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D013498", "original_object": "REACT:R-HSA-70171"}
{"subject": "MONDO:0018116", "predicate": "biolink:affects", "object": "CHEBI:28260", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012024", "original_object": "CHEBI:28260"}
{"subject": "UBERON:2002006", "predicate": "biolink:related_to", "object": "GO:0046930", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:2002006", "original_object": "UBERON:0008915"}
{"subject": "MONDO:0008269", "predicate": "biolink:has_part", "object": "MONDO:0017425", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001177", "original_object": "HP:0100258"}
{"subject": "NCIT:C14050", "predicate": "biolink:subclass_of", "object": "UMLS:C1510464", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C14050", "original_object": "NCIT:C13303"}
{"subject": "HP:0030126", "predicate": "biolink:causes", "object": "HP:0100608", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00396_MESH_D008796_1", "DB00603_MESH_D008796_1", "DB00717_MESH_D008796_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0030126", "original_object": "MESH:D008796"}
{"subject": "HP:0005227", "predicate": "biolink:related_to", "object": "MONDO:0005166", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C6728", "original_object": "NCIT:C3296"}
{"subject": "GO:0021552", "predicate": "biolink:affects", "object": "UBERON:0003052", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0021552", "original_object": "UBERON:0003052"}
{"subject": "GO:0099612", "predicate": "biolink:related_to", "object": "UBERON:0001016", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0099612", "original_object": "UBERON:0001016"}
{"subject": "UBERON:0004356", "predicate": "biolink:produces", "object": "PR:000007499", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004356", "original_object": "PR:000007499"}
{"subject": "GO:0050454", "predicate": "biolink:has_participant", "object": "CHEBI:133980", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0050454", "original_object": "CHEBI:133980"}
{"subject": "CL:0000515", "predicate": "biolink:contributes_to", "object": "UBERON:0001015", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000515", "original_object": "UBERON:0001015"}
{"subject": "GO:1990191", "predicate": "biolink:related_to", "object": "CHEBI:30411", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990191", "original_object": "CHEBI:30411"}
{"subject": "MONDO:0800180", "predicate": "biolink:causes", "object": "NCBIGene:1371", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0800180", "original_object": "HGNC:2321"}
{"subject": "GO:0015842", "predicate": "biolink:preventative_for_condition", "object": "GO:0042420", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12161_MESH_D000071057_1", "DB12161_MESH_D006816_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015842", "original_object": "GO:0042420"}
{"subject": "REACT:R-HSA-1169410", "predicate": "biolink:disrupts", "object": "NCBITaxon:10407", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00105_MESH_D019694_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-1169410", "original_object": "NCBITaxon:10407"}
{"subject": "GO:0006412", "predicate": "biolink:affects", "object": "UniProtKB:A9UF02", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04865_MESH_D015464_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0006412", "original_object": "UniProtKB:A9UF02"}
{"subject": "GO:0042311", "predicate": "biolink:contributes_to", "object": "GO:0060087", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08931_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042311", "original_object": "GO:0060087"}
{"subject": "GO:0003092", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01324_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0003092", "original_object": "MESH:D006973"}
{"subject": "CHEBI:87282", "predicate": "biolink:related_to", "object": "CHEBI:16236", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:87282", "original_object": "CHEBI:16236"}
{"subject": "GO:0071391", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:50114", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04938_MESH_D004414_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071391", "original_object": "MESH:D004967"}
{"subject": "GO:0006470", "predicate": "biolink:occurs_in", "object": "UMLS:C0027108", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01020_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006470", "original_object": "UMLS:C0027108"}
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{"subject": "CHEBI:4646", "predicate": "biolink:has_metabolite", "object": "CHEBI:28918", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00449_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C015173", "original_object": "MESH:D004837"}
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{"subject": "HP:0005968", "predicate": "biolink:positively_correlated_with", "object": "HP:0031217", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00286_MESH_D019584_1", "DB01395_MESH_D019584_1", "DB04575_MESH_D019584_1", "DB06401_MESH_D019584_1", "DB06710_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0005968", "original_object": "MESH:D019584"}
{"subject": "GO:0004714", "predicate": "biolink:regulates", "object": "UMLS:C2350409", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00046_MESH_D003922_1", "DB00046_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004714", "original_object": "UMLS:C2350409"}
{"subject": "UBERON:0007633", "predicate": "biolink:located_in", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0007633", "original_object": "NCBITaxon:6072"}
{"subject": "MONDO:0001577", "predicate": "biolink:has_part", "object": "CHEBI:29105", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "complex_context": ["M2-1:Zn2+"], "original_subject": "DOID:1273", "original_object": "CHEBI:29105"}
{"subject": "GO:0018393", "predicate": "biolink:occurs_in", "object": "NCBIGene:4137", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08842_MESH_D000544_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0018393", "original_object": "UniProtKB:P10636"}
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{"subject": "CHEBI:26865", "predicate": "biolink:has_part", "object": "CHEBI:33353", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:26865", "original_object": "CHEBI:33353"}
{"subject": "UBERON:0014635", "predicate": "biolink:overlaps", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0014635", "original_object": "NCBITaxon:6072"}
{"subject": "NCBIGene:11188", "predicate": "biolink:affects", "object": "UBERON:0000013", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09242_MESH_D000075222_1", "DB11738_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:Q9Y2I1", "original_object": "UBERON:0000013"}
{"subject": "CHEBI:134126", "predicate": "biolink:subclass_of", "object": "CHEBI:60004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:134126", "original_object": "CHEBI:60004"}
{"subject": "MONDO:0001244", "predicate": "biolink:affects", "object": "CHEBI:28384", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0011892", "original_object": "CHEBI:28384"}
{"subject": "GO:0022028", "predicate": "biolink:related_to", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0022028", "original_object": "NCBITaxon:6072"}
{"subject": "MESH:C099150", "predicate": "biolink:regulates", "object": "GO:0007049", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05109_MESH_D007890_1", "DB05109_MESH_D008080_1", "DB05109_MESH_D010051_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C099150", "original_object": "GO:0007049"}
{"subject": "CHEBI:17351", "predicate": "biolink:subclass_of", "object": "CHEBI:36009", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17351", "original_object": "CHEBI:36009"}
{"subject": "UBERON:0007475", "predicate": "biolink:composed_primarily_of", "object": "GO:0031012", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0007475", "original_object": "GO:0031012"}
{"subject": "GO:0015740", "predicate": "biolink:has_input", "object": "CHEBI:61336", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015740", "original_object": "CHEBI:61336"}
{"subject": "MONDO:0007254", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "CHEBI:31522", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:7770922", "PMC:7904601"], "tmkp_confidence_score": 0.7544301866617116, "sentences": "The BSA/DOX@ZIF-8 showed greater antitumor efficacy than that of free DOX against breast cancer cell line MCF-7.|NA|The free DOX, R@DOX and X-R@DOX induced competitive apoptosis on 4T1 breast cancer cells, which led 5.81%, 9.24% and 8.73% of 4T1 cells become apoptosis, respectively.|NA", "tmkp_ids": ["tmkp:8266ff9d88b4fe09467330f07b77232c075615cb744d643de7ad4b874264ec6e", "tmkp:67d38e73a7b4b35021e4f9488efdc9e74737c16798607b9d28db8156cb3c91a5"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "MONDO:0007254", "original_object": "CHEBI:31522"}
{"subject": "CHEBI:15552", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:5739", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01240_MESH_D000081029_1", "DB01240_MESH_D003139_1", "DB01240_MESH_D003371_1", "DB01240_MESH_D006976_1", "DB01240_MESH_D012220_1", "DB01240_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011464", "original_object": "UniProtKB:P43119"}
{"subject": "CHEBI:32586", "predicate": "biolink:has_part", "object": "CHEBI:32149", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:32586", "original_object": "CHEBI:32149"}
{"object": "CL:0002453", "predicate": "biolink:has_part", "subject": "CL:0000125", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0002453", "original_subject": "CL:0000125"}
{"subject": "MESH:C078049", "predicate": "biolink:regulates", "object": "GO:0009340", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01044_MESH_D003234_1", "DB01044_MESH_D018410_1", "DB01044_MESH_D061387_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C078049", "original_object": "GO:0009340"}
{"subject": "NCBIGene:3673", "predicate": "biolink:increases_sensitivity_to", "object": "CHEBI:16236", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "NCBITaxon:10116", "publications": ["PMID:18234883"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:3673", "original_object": "MESH:D000431"}
{"subject": "GO:0060612", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D005230", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060612", "original_object": "MESH:D005230"}
{"subject": "UMLS:C4552849", "predicate": "biolink:subclass_of", "object": "UMLS:C5856882", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C117231", "original_object": "NCIT:C201545"}
{"subject": "CL:0000092", "predicate": "biolink:positively_correlated_with", "object": "GO:0045453", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00153_MESH_D010024_1", "DB00153_MESH_D015663_1", "DB00282_MESH_C562390_1", "DB00282_MESH_D010001_1", "DB00399_MESH_C562390_1", "DB00399_MESH_D010001_1", "DB06255_MESH_C562390_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000092", "original_object": "GO:0045453"}
{"subject": "GO:0098684", "predicate": "biolink:overlaps", "object": "UBERON:0004456", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098684", "original_object": "UBERON:0004456"}
{"subject": "NCBIGene:153", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18357", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00571_MESH_D002312_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08588", "original_object": "MESH:D009638"}
{"subject": "CHEBI:9332", "predicate": "biolink:applied_to_treat", "object": "UMLS:C0421162", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2514", "original_object": "UMLS:C0421162"}
{"object": "GO:0043039", "predicate": "biolink:has_participant", "subject": "GO:0006412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13092_MESH_D000073605_1", "DB13092_MESH_D000152_1", "DB13092_MESH_D000196_1", "DB13092_MESH_D000881_1", "DB13092_MESH_D001991_1", "DB13092_MESH_D002006_1", "DB13092_MESH_D002602_1", "DB13092_MESH_D003235_1", "DB13092_MESH_D006069_1", "DB13092_MESH_D006100_1", "DB13092_MESH_D008219_1", "DB13092_MESH_D009956_1", "DB13092_MESH_D010612_1", "DB13092_MESH_D011014_1", "DB13092_MESH_D011778_1", "DB13092_MESH_D012061_1", "DB13092_MESH_D012373_1", "DB13092_MESH_D012852_1", "DB13092_MESH_D013203_1", "DB13092_MESH_D013587_1", "DB13092_MESH_D014141_1", "DB13092_MESH_D014552_1", "DB13092_MESH_D015001_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0043039", "original_subject": "GO:0006412"}
{"subject": "UBERON:0001003", "predicate": "biolink:positively_correlated_with", "object": "HP:0040189", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01243_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001003", "original_object": "HP:0040189"}
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{"subject": "CHEBI:17650", "predicate": "biolink:produces", "object": "CHEBI:17650", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00741_MESH_C562390_1", "DB00741_MESH_D000224_1", "DB00741_MESH_D000309_1", "DB00741_MESH_D000744_1", "DB00741_MESH_D001172_1", "DB00741_MESH_D001249_1", "DB00741_MESH_D001327_1", "DB00741_MESH_D001607_1", "DB00741_MESH_D001929_1", "DB00741_MESH_D002062_1", "DB00741_MESH_D003873_1", "DB00741_MESH_D003874_1", "DB00741_MESH_D003876_1", "DB00741_MESH_D003877_1", "DB00741_MESH_D004892_1", "DB00741_MESH_D005076_1", "DB00741_MESH_D005128_1", "DB00741_MESH_D006484_1", "DB00741_MESH_D008180_1", "DB00741_MESH_D008228_1", "DB00741_MESH_D009140_1", "DB00741_MESH_D009182_1", "DB00741_MESH_D010392_1", "DB00741_MESH_D011015_1", "DB00741_MESH_D011538_1", "DB00741_MESH_D011565_1", "DB00741_MESH_D012507_1", "DB00741_MESH_D012713_1", "DB00741_MESH_D013167_1", "DB00741_MESH_D013585_1", "DB00741_MESH_D013966_1", "DB00741_MESH_D015210_1", "DB00741_MESH_D015535_1", "DB00741_MESH_D052256_1", "DB00741_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006854", "original_object": "MESH:C007133"}
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{"subject": "MONDO:0004992", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "UMLS:C0002563", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9288050"], "tmkp_confidence_score": 0.2804823241697879, "sentences": "CsI(Na)@MgO@DSPE-Folate nanoparticles (CIS@M-F) and 5-ALA are separately administered but colocalized in cancer cells to enable RDT.|NA", "tmkp_ids": ["tmkp:8e8ce2ce7650e45328202fc2680b7acccbc731d661170182a17059cda88d0868"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "MONDO:0004992", "original_object": "DRUGBANK:DB00855"}
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{"subject": "UMLS:C0282629", "predicate": "biolink:in_taxon", "object": "NCBITaxon:3052230", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09102_MESH_D019698_1", "DB09296_MESH_D019698_1", "DB11613_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0282629", "original_object": "NCBITaxon:3052230"}
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{"subject": "CHEBI:15627", "predicate": "biolink:regulates", "object": "HP:4000007", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13036_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D013928", "original_object": "HP:4000007"}
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{"subject": "CHEBI:36584", "predicate": "biolink:treats", "object": "HP:0012735", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:3508", "original_object": "UMLS:C0010200"}
{"subject": "MESH:D004391", "predicate": "biolink:affects", "object": "MONDO:0005252", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:25667096"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D004391", "original_object": "MESH:D006333"}
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{"subject": "UBERON:0001866", "predicate": "biolink:treats", "object": "MONDO:0011438", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00655_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D012629", "original_object": "MESH:D000152"}
{"subject": "CL:0000170", "predicate": "biolink:related_to", "object": "CHEBI:5391", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000170", "original_object": "CHEBI:5391"}
{"subject": "NCBIGene:2550", "predicate": "biolink:regulates", "object": "HGNC.FAMILY:563", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00659_MESH_D000437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:Q9UBS5", "original_object": "HGNC.FAMILY:563"}
{"subject": "CHEBI:29888", "predicate": "biolink:regulates", "object": "GO:0030282", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09105_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C107241", "original_object": "GO:0030282"}
{"subject": "CHEBI:6043", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0150012", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1500", "original_object": "UMLS:C0150012"}
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{"subject": "GO:0042310", "predicate": "biolink:has_phenotype", "object": "MONDO:0005044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08932_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042310", "original_object": "HP:0000822"}
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{"subject": "CHEBI:84677", "predicate": "biolink:related_to", "object": "CHEBI:16394", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:84677", "original_object": "CHEBI:16394"}
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{"subject": "CHEBI:24564", "predicate": "biolink:has_metabolite", "object": "CHEBI:73080", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00488_MESH_D010051_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006585", "original_object": "CHEBI:73080"}
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{"subject": "CHEBI:9584", "predicate": "biolink:related_to", "object": "CHEBI:60311", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:9584", "original_object": "CHEBI:60311"}
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{"subject": "CHEBI:17303", "predicate": "biolink:affects", "object": "HGNC.FAMILY:245", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00295_MESH_D010146_1", "DB00295_MESH_D059350_1", "DB00318_MESH_D003139_1", "DB00318_MESH_D003371_1", "DB00318_MESH_D010146_1", "DB00318_MESH_D010612_1", "DB00318_MESH_D012220_1", "DB00318_MESH_D012912_1", "DB00318_MESH_D018781_1", "DB00318_MESH_D020773_1", "DB00318_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D009020", "original_object": "HGNC.FAMILY:245"}
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{"subject": "CHEBI:9328", "predicate": "biolink:negatively_correlated_with", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00359_MESH_D003093_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D013411", "original_object": "GO:0006954"}
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{"subject": "CHEBI:16236", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005302", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:25209690"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D000431", "original_object": "MESH:D001289"}
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{"subject": "GO:0005183", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002146", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00624_MESH_D007006_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005183", "original_object": "MESH:D007006"}
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{"subject": "MONDO:0005469", "predicate": "biolink:occurs_in", "object": "MONDO:0005180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06262_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001278", "original_object": "MESH:D010300"}
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{"subject": "CHEBI:94392", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:15430", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01218_MESH_D016778_1", "DB01218_MESH_D016780_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C023768", "original_object": "CHEBI:15430"}
{"subject": "MESH:D053260", "predicate": "biolink:negatively_correlated_with", "object": "EFO:0004344", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:33905944"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D053260", "original_object": "MESH:D001724"}
{"subject": "GO:0005248", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005027", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05541_MESH_D004828_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005248", "original_object": "HP:0001250"}
{"subject": "UBERON:0022282", "predicate": "biolink:composed_primarily_of", "object": "CHEBI:18059", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0022282", "original_object": "CHEBI:18059"}
{"object": "NCBIGene:3921", "predicate": "biolink:has_participant", "subject": "NCBIGene:3921", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "NCIT:C17306", "original_subject": "NCIT:C107450"}
{"subject": "GO:0005739", "predicate": "biolink:located_in", "object": "CL:0000198", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06774_MESH_D001416_1", "DB06774_MESH_D009437_1", "DB06774_MESH_D051474_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005739", "original_object": "CL:0000198"}
{"subject": "GO:0007274", "predicate": "biolink:predisposes_to_condition", "object": "HP:0003690", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00536_MESH_D015624_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007274", "original_object": "HP:0003690"}
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{"subject": "CHEBI:17303", "predicate": "biolink:subclass_of", "object": "CHEBI:50996", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17303", "original_object": "CHEBI:50996"}
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{"subject": "CHEBI:53269", "predicate": "biolink:has_part", "object": "CHEBI:68632", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:53269", "original_object": "CHEBI:68632"}
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{"subject": "CL:0001063", "predicate": "biolink:manifestation_of", "object": "MONDO:0018874", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00987_MESH_D015470_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0001063", "original_object": "MESH:D015470"}
{"subject": "NCBIGene:324", "predicate": "biolink:gene_associated_with_condition", "object": "HP:0005227", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C17687", "original_object": "NCIT:C3339"}
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{"subject": "NCBITaxon:2", "predicate": "biolink:produces", "object": "CHEBI:16134", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01220_MESH_D006501_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:2", "original_object": "MESH:D000641"}
{"subject": "NCBIGene:1909", "predicate": "biolink:capable_of", "object": "GO:0042310", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08932_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P25101", "original_object": "GO:0042310"}
{"subject": "CHEBI:12777", "predicate": "biolink:located_in", "object": "CL:0000632", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17336", "original_object": "CL:0000632"}
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{"subject": "MESH:D052638", "predicate": "biolink:affects", "object": "HP:0001622", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:27120296"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D052638", "original_object": "MESH:D047928"}
{"subject": "MESH:D012338", "predicate": "biolink:located_in", "object": "GO:0015934", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01082_MESH_D002006_1", "DB01082_MESH_D002602_1", "DB01082_MESH_D006100_1", "DB01082_MESH_D010930_1", "DB01082_MESH_D014397_1", "DB01082_MESH_D014406_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D012338", "original_object": "GO:0015934"}
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{"subject": "GO:0030432", "predicate": "biolink:affects", "object": "GO:0120054", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00295_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0030432", "original_object": "GO:0120054"}
{"subject": "CHEBI:5551", "predicate": "biolink:regulates", "object": "HP:0031245", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00874_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D006140", "original_object": "HP:0031245"}
{"subject": "HP:0011104", "predicate": "biolink:contributes_to", "object": "GO:0045777", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00232_MESH_D006973_1", "DB00310_MESH_D006973_1", "DB00436_MESH_D006973_1", "DB00524_MESH_D006973_2", "DB00695_MESH_D006973_1", "DB00808_MESH_D006973_1", "DB00999_MESH_D006973_1", "DB02925_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0011104", "original_object": "GO:0045777"}
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{"subject": "CL:0000921", "predicate": "biolink:capable_of", "object": "GO:0043208", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000921", "original_object": "GO:0043208"}
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{"subject": "CHEBI:39585", "predicate": "biolink:subclass_of", "object": "CHEBI:60004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:192512", "original_object": "CHEBI:60004"}
{"subject": "CHEBI:17303", "predicate": "biolink:treats", "object": "HP:0012532", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1845", "original_object": "UMLS:C0150055"}
{"subject": "CHEBI:135732", "predicate": "biolink:disrupts", "object": "NCBITaxon:210", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05197_MESH_D013276_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C035032", "original_object": "NCBITaxon:210"}
{"subject": "UMLS:C0071568", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "UBERON:2000006", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:18176182"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C042705", "original_object": "MESH:D015452"}
{"subject": "GO:0006572", "predicate": "biolink:produces", "object": "CHEBI:30907", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00348_MESH_D020176_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006572", "original_object": "MESH:C105171"}
{"object": "UBERON:0002465", "predicate": "biolink:located_in", "subject": "MONDO:0018908", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00997_MESH_D008228_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0002465", "original_subject": "MESH:D008228"}
{"subject": "UBERON:0000912", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0004247", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000912", "original_object": "MESH:D010437"}
{"subject": "UMLS:C0872968", "predicate": "biolink:has_metabolite", "object": "MESH:D000080084", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00056_MESH_D015470_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000079982", "original_object": "MESH:D000080084"}
{"subject": "UMLS:C1711306", "predicate": "biolink:subclass_of", "object": "MONDO:0005004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C47821", "original_object": "NCIT:C36815"}
{"subject": "MONDO:0009637", "predicate": "biolink:affects", "object": "GO:0005739", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0003737", "original_object": "GO:0005739"}
{"subject": "UBERON:0001870", "predicate": "biolink:contributes_to", "object": "GO:0051823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D001714_2", "DB00313_MESH_D001714_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001870", "original_object": "GO:0051823"}
{"subject": "GO:0050806", "predicate": "biolink:actively_involved_in", "object": "GO:1904058", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00564_MESH_D014277_1", "DB00564_MESH_D020435_1", "DB00645_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0050806", "original_object": "GO:1904058"}
{"subject": "PR:000049983", "predicate": "biolink:related_to", "object": "CHEBI:24867", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:000049983", "original_object": "CHEBI:24867"}
{"subject": "NCBIGene:4087", "predicate": "biolink:genetically_associated_with", "object": "UMLS:C0600520", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:6768", "original_object": "UMLS:C0600520"}
{"object": "MESH:D012338", "predicate": "biolink:has_part", "subject": "UniProtKB:Q2G0P0", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01190_MESH_D011023_1", "DB01190_MESH_D013203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:D012338", "original_subject": "UniProtKB:Q2G0P0"}
{"subject": "UBERON:0001798", "predicate": "biolink:composed_primarily_of", "object": "UBERON:0001797", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001798", "original_object": "UBERON:0001797"}
{"subject": "MESH:D008077", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0002277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00175_MESH_D001161_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008077", "original_object": "MESH:D001161"}
{"subject": "CHEBI:72999", "predicate": "biolink:capable_of", "object": "GO:0043129", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09114_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C081581", "original_object": "GO:0043129"}
{"subject": "NCBIGene:1815", "predicate": "biolink:related_to", "object": "CHEBI:18243", "primary_knowledge_source": "infores:ctd", "description": "molecularly interacts with", "taxon": "NCBITaxon:10116", "publications": ["PMID:15716360"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:1815", "original_object": "MESH:D004298"}
{"subject": "UBERON:0001896", "predicate": "biolink:regulates", "object": "HP:0012735", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00327_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0001896", "original_object": "MESH:D003371"}
{"subject": "HP:0010617", "predicate": "biolink:related_to", "object": "UMLS:C0225317", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C6947", "original_object": "NCIT:C12471"}
{"subject": "GO:1990231", "predicate": "biolink:capable_of", "object": "GO:0060337", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990231", "original_object": "GO:0060337"}
{"subject": "NCBITaxon:1313", "predicate": "biolink:occurs_in", "object": "MONDO:0004652", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01211_MESH_D018410_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1313", "original_object": "MESH:D018410"}
{"subject": "GO:0030073", "predicate": "biolink:regulates", "object": "MESH:D001786", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01382_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0030073", "original_object": "MESH:D001786"}
{"subject": "CHEBI:3127", "predicate": "biolink:affects", "object": "UBERON:0034729", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00612_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D017298", "original_object": "UBERON:0034729"}
{"subject": "MESH:D012338", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:45050123", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00207_MESH_D061387_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D012338", "original_object": "UniProtKB:Q9Z9A3"}
{"subject": "GO:0098991", "predicate": "biolink:overlaps", "object": "GO:0035725", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098991", "original_object": "GO:0035725"}
{"subject": "CHEBI:15422", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5661", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05630_MESH_D007896_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000255", "original_object": "NCBITaxon:5661"}
{"subject": "NCBIGene:3641571", "predicate": "biolink:produces", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01263_MESH_D009181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P10613", "original_object": "MESH:D004875"}
{"subject": "GO:0030520", "predicate": "biolink:treats", "object": "MONDO:0001196", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01708_MESH_D004414_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030520", "original_object": "MESH:D004414"}
{"subject": "NCBIGene:7442", "predicate": "biolink:regulates", "object": "CL:0000197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00405_MESH_D011537_1", "DB00434_MESH_D011537_1", "DB00557_MESH_D011537_1", "DB01084_MESH_D011537_1", "DB01114_MESH_D011537_1", "DB06691_MESH_D011537_1", "DB08799_MESH_D011537_1", "DB09555_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:Q8NER1", "original_object": "CL:0000197"}
{"subject": "GO:0016063", "predicate": "biolink:affects", "object": "NCBIGene:6010", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00162_MESH_D001361_1", "DB00162_MESH_D014802_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0016063", "original_object": "UniProtKB:P08100"}
{"subject": "CHEBI:6485", "predicate": "biolink:similar_to", "object": "UMLS:C0040165", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB01583", "original_object": "DRUGBANK:DB00451"}
{"subject": "CHEBI:16236", "predicate": "biolink:affects", "object": "MONDO:0000408", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:22666445"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D000431", "original_object": "MESH:D063647"}
{"object": "GO:0004714", "predicate": "biolink:has_participant", "subject": "REACT:R-HSA-74713", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09564_MESH_D003920_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0004714", "original_subject": "REACT:R-HSA-74713"}
{"subject": "NCBIGene:1813", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01618_MESH_D012559_1", "DB11757_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P14416", "original_object": "MESH:D004298"}
{"subject": "GO:0051381", "predicate": "biolink:regulates", "object": "GO:0023041", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00341_MESH_D012912_1", "DB00434_MESH_D012912_1", "DB00434_MESH_D012912_2", "DB00637_MESH_D012912_1", "DB00950_MESH_D012912_1", "DB08799_MESH_D012912_1", "DB09488_MESH_D012912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0051381", "original_object": "GO:0023041"}
{"subject": "MESH:C048833", "predicate": "biolink:affects", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00745_MESH_D009290_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:C048833", "original_object": "MESH:D006632"}
{"subject": "CHEBI:16714", "predicate": "biolink:has_metabolite", "object": "CHEBI:17303", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00318_MESH_D003139_1", "DB00318_MESH_D003371_1", "DB00318_MESH_D005334_1", "DB00318_MESH_D010146_1", "DB00318_MESH_D010612_1", "DB00318_MESH_D012220_1", "DB00318_MESH_D012912_1", "DB00318_MESH_D018781_1", "DB00318_MESH_D020773_1", "DB00318_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D003061", "original_object": "MESH:D009020"}
{"subject": "GO:0000380", "predicate": "biolink:produces", "object": "UniProtKB:B4DP61", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13161_MESH_D009134_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000380", "original_object": "UniProtKB:B4DP61"}
{"subject": "NCBIGene:5578", "predicate": "biolink:contributes_to", "object": "GO:0051823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D001714_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P17252", "original_object": "GO:0051823"}
{"subject": "HGNC.FAMILY:1203", "predicate": "biolink:affects", "object": "CHEBI:26708", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01182_MESH_D001281_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "transport", "original_subject": "HGNC.FAMILY:1203", "original_object": "MESH:D012964"}
{"subject": "GO:0007189", "predicate": "biolink:affects", "object": "GO:0004691", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00374_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0007189", "original_object": "GO:0004691"}
{"subject": "GO:0051145", "predicate": "biolink:causes", "object": "GO:0030485", "primary_knowledge_source": "infores:go", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:phenio"], "knowledge_level": "not_provided", "agent_type": "not_provided", "id": "urn:uuid:3ce0424a-79a2-433a-b83a-9ac24b7e9f50", "category": ["biolink:Association", "biolink:Entity"], "file_source": "phenio_edges", "provided_by": "phenio_edges", "original_predicate": "RO:0002315", "grouping_key": "GO:0051145||biolink:causes|CL:0000192", "original_subject": "GO:0051145", "original_object": "CL:0000192"}
{"subject": "CHEBI:34911", "predicate": "biolink:disrupts", "object": "UniProtKB:Q2VKV7", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04930_MESH_D012532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D026023", "original_object": "UniProtKB:Q2VKV7"}
{"subject": "CHEBI:18085", "predicate": "biolink:occurs_in", "object": "GO:0005764", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01279_MESH_D009087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006025", "original_object": "GO:0005764"}
{"subject": "UBERON:0000176", "predicate": "biolink:causes", "object": "HP:0025095", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00972_MESH_D006255_1", "DB00972_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000176", "original_object": "HP:0025095"}
{"subject": "CHEBI:5790", "predicate": "biolink:regulates", "object": "UBERON:0001896", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00327_MESH_D003139_1", "DB00327_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D004091", "original_object": "UBERON:0001896"}
{"subject": "UBERON:0001090", "predicate": "biolink:has_part", "object": "CHEBI:16336", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001090", "original_object": "CHEBI:16336"}
{"subject": "UMLS:C0001047", "predicate": "biolink:has_metabolite", "object": "CHEBI:15356", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06151_MESH_D000686_2", "DB06151_MESH_D001987_2", "DB06151_MESH_D001991_2", "DB06151_MESH_D003550_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000111", "original_object": "CHEBI:15356"}
{"subject": "UBERON:4000115", "predicate": "biolink:has_part", "object": "CHEBI:52255", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:4000115", "original_object": "CHEBI:52255"}
{"subject": "UBERON:0001574", "predicate": "biolink:related_to", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001574", "original_object": "NCBITaxon:6072"}
{"subject": "HP:0032263", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005068", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00335_MESH_D009203_1", "DB00722_MESH_D009203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0032263", "original_object": "MESH:D009203"}
{"subject": "MONDO:0005804", "predicate": "biolink:affects", "object": "PR:000013246", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000870", "original_object": "PR:000013246"}
{"subject": "GO:0043209", "predicate": "biolink:related_to", "object": "UBERON:0000061", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000345", "original_object": "UBERON:0000061"}
{"subject": "UMLS:C0001047", "predicate": "biolink:disrupts", "object": "GO:0042710", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06151_MESH_D001991_1", "DB06151_MESH_D003550_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000111", "original_object": "GO:0042710"}
{"subject": "UBERON:0005304", "predicate": "biolink:positively_correlated_with", "object": "GO:0050892", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08900_MESH_D012778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0005304", "original_object": "GO:0050892"}
{"subject": "NCBIGene:9900", "predicate": "biolink:affects", "object": "GO:0098982", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01202_MESH_D004828_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:Q7L0J3", "original_object": "GO:0098982"}
{"subject": "UBERON:0003092", "predicate": "biolink:has_part", "object": "PR:000027222", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003092", "original_object": "PR:000027222"}
{"subject": "CHEBI:39867", "predicate": "biolink:causes", "object": "UMLS:C1868980", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00313", "original_object": "UMLS:C1868980"}
{"subject": "GO:0004714", "predicate": "biolink:regulates", "object": "NCBIGene:207", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01306_MESH_D003920_1", "DB01307_MESH_D003920_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004714", "original_object": "UniProtKB:P31749"}
{"subject": "NCBIGene:9378", "predicate": "biolink:acts_upstream_of", "object": "GO:0098990", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:P58400", "original_object": "GO:0098990"}
{"subject": "UMLS:C0023775", "predicate": "biolink:disrupts", "object": "GO:0006811", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002179_1", "DB00646_MESH_D002180_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0023775", "original_object": "GO:0006811"}
{"subject": "NCBIGene:54209", "predicate": "biolink:acts_upstream_of_or_within_positive_effect", "object": "GO:0038160", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:33097708"], "original_subject": "UniProtKB:Q9NZC2", "original_object": "GO:0038160"}
{"subject": "MONDO:0005004", "predicate": "biolink:subclass_of", "object": "UMLS:C1513974", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C36815", "original_object": "NCIT:C36765"}
{"subject": "UBERON:0001707", "predicate": "biolink:correlated_with", "object": "MONDO:0004979", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01410_MESH_D001249_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001707", "original_object": "MESH:D001249"}
{"subject": "UBERON:0001295", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0021251", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00351_MESH_D016889_1", "DB00396_MESH_D016889_1", "DB00603_MESH_D016889_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001295", "original_object": "MESH:D016889"}
{"subject": "CHEBI:28786", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D012135", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:11874814"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010269", "original_object": "MESH:D012135"}
{"subject": "GO:0071159", "predicate": "biolink:regulates", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00434_MESH_D065631_1", "DB01114_MESH_D065631_1", "DB04837_MESH_D012220_1", "DB04837_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0071159", "original_object": "GO:0006954"}
{"subject": "UMLS:C2607955", "predicate": "biolink:causes", "object": "GO:0008219", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C2607955", "original_object": "GO:0008219"}
{"subject": "NCBIGene:154", "predicate": "biolink:regulates", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01214_MESH_D005902_1", "DB01214_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P07550", "original_object": "UBERON:0001796"}
{"subject": "CHEBI:30769", "predicate": "biolink:disrupts", "object": "UBERON:0000912", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09154_MESH_D003139_1", "DB09154_MESH_D003371_1", "DB09154_MESH_D012220_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000077559", "original_object": "UBERON:0000912"}
{"subject": "CHEBI:91583", "predicate": "biolink:disrupts", "object": "GO:0005886", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01058_MESH_D009889_1", "DB01058_MESH_D012552_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011223", "original_object": "GO:0005886"}
{"subject": "CL:0005020", "predicate": "biolink:coexists_with", "object": "UBERON:0004536", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0005020", "original_object": "UBERON:0004536"}
{"subject": "CHEBI:15854", "predicate": "biolink:similar_to", "object": "CHEBI:171719", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00468", "original_object": "DRUGBANK:DB01346"}
{"subject": "CHEBI:6437", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0020039", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1563", "original_object": "UMLS:C0020039"}
{"object": "MONDO:0006975", "predicate": "biolink:causes", "subject": "GO:0030485", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0006975", "original_subject": "CL:0000192"}
{"subject": "NCBIGene:2554", "predicate": "biolink:capable_of", "object": "GO:0022851", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09166_MESH_D001008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P14867", "original_object": "GO:0022851"}
{"subject": "CHEBI:71417", "predicate": "biolink:affects", "object": "GO:0030488", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01168_MESH_D006689_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D011344", "original_object": "GO:0030488"}
{"subject": "HGNC.FAMILY:404", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR11716", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D016410_1", "DB00240_MESH_D016460_1", "DB01234_MESH_C562390_1", "DB01234_MESH_D000744_1", "DB01234_MESH_D000799_1", "DB01234_MESH_D001172_1", "DB01234_MESH_D001249_1", "DB01234_MESH_D001607_1", "DB01234_MESH_D001929_1", "DB01234_MESH_D002051_1", "DB01234_MESH_D002062_1", "DB01234_MESH_D003233_1", "DB01234_MESH_D003320_1", "DB01234_MESH_D003424_1", "DB01234_MESH_D003873_1", "DB01234_MESH_D003874_1", "DB01234_MESH_D003876_1", "DB01234_MESH_D003877_1", "DB01234_MESH_D004892_1", "DB01234_MESH_D005076_1", "DB01234_MESH_D005128_1", "DB01234_MESH_D006689_1", "DB01234_MESH_D007500_1", "DB01234_MESH_D007627_1", "DB01234_MESH_D007634_1", "DB01234_MESH_D007819_1", "DB01234_MESH_D008179_1", "DB01234_MESH_D008180_1", "DB01234_MESH_D008224_1", "DB01234_MESH_D008228_1", "DB01234_MESH_D009101_1", "DB01234_MESH_D009103_1", "DB01234_MESH_D009140_1", "DB01234_MESH_D009182_1", "DB01234_MESH_D009404_1", "DB01234_MESH_D009450_1", "DB01234_MESH_D010032_1", "DB01234_MESH_D010392_1", "DB01234_MESH_D011538_1", "DB01234_MESH_D011565_1", "DB01234_MESH_D011657_1", "DB01234_MESH_D012214_1", "DB01234_MESH_D012393_1", "DB01234_MESH_D012507_1", "DB01234_MESH_D012628_1", "DB01234_MESH_D012713_1", "DB01234_MESH_D012871_1", "DB01234_MESH_D013167_1", "DB01234_MESH_D013716_1", "DB01234_MESH_D013717_2", "DB01234_MESH_D013966_1", "DB01234_MESH_D014235_1", "DB01234_MESH_D014391_1", "DB01234_MESH_D014605_1", "DB01234_MESH_D014606_1", "DB01234_MESH_D015210_1", "DB01234_MESH_D015212_1", "DB01234_MESH_D015535_1", "DB01234_MESH_D015863_1", "DB01234_MESH_D016403_1", "DB01234_MESH_D016410_1", "DB01234_MESH_D016460_1", "DB01234_MESH_D029503_1", "DB01234_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "HGNC.FAMILY:404", "original_object": "PANTHER.FAMILY:PTHR11716"}
{"subject": "CHEBI:17303", "predicate": "biolink:causes", "object": "UMLS:C1142412", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00295", "original_object": "UMLS:C1142412"}
{"subject": "MONDO:0002012", "predicate": "biolink:causes", "object": "MONDO:0002320", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00115_MESH_D001361_1", "DB00115_MESH_D014806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002912", "original_object": "HP:0000707"}
{"subject": "GO:0071420", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00748_MESH_D003139_1", "DB00748_MESH_D003233_2", "DB00748_MESH_D006255_1", "DB00748_MESH_D011537_1", "DB00748_MESH_D012223_1", "DB00748_MESH_D014581_1", "DB00748_MESH_D065631_1", "DB01075_MESH_D003233_1", "DB01075_MESH_D006255_1", "DB01075_MESH_D012223_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071420", "original_object": "MESH:D006632"}
{"subject": "GO:0023041", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002009", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00344_MESH_D003865_1", "DB06148_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0023041", "original_object": "MESH:D003865"}
{"subject": "GO:0014046", "predicate": "biolink:located_in", "object": "UBERON:0001910", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06144_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0014046", "original_object": "UBERON:0001910"}
{"subject": "CHEBI:16113", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005098", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00175_MESH_D020521_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002784", "original_object": "MESH:D020521"}
{"subject": "UMLS:C0657912", "predicate": "biolink:causes", "object": "UMLS:C1142135", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00230", "original_object": "UMLS:C1142135"}
{"subject": "UBERON:0004128", "predicate": "biolink:causes", "object": "UBERON:0004880", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004128", "original_object": "UBERON:0004880"}
{"object": "GO:0031929", "predicate": "biolink:causes", "subject": "GO:0038201", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0031929", "original_subject": "GO:0038201"}
{"subject": "GO:0030485", "predicate": "biolink:related_to", "object": "CL:0008000", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000192", "original_object": "CL:0008000"}
{"subject": "CHEMBL.COMPOUND:CHEMBL2108183", "predicate": "biolink:treats", "object": "UMLS:C3266799", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4854", "original_object": "UMLS:C3266799"}
{"subject": "CHEBI:46345", "predicate": "biolink:has_active_ingredient", "object": "PUBCHEM.COMPOUND:10255482", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09256_MESH_D013274_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005472", "original_object": "MESH:C025635"}
{"subject": "CHEBI:16113", "predicate": "biolink:located_in", "object": "UBERON:0002110", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01586_MESH_D002769_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002784", "original_object": "UBERON:0002110"}
{"subject": "HP:0000616", "predicate": "biolink:negatively_correlated_with", "object": "HP:0007663", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01057_MESH_D000080362_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000616", "original_object": "HP:0007663"}
{"subject": "MONDO:0003947", "predicate": "biolink:disrupts", "object": "GO:0023035", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0003947", "original_object": "GO:0023035"}
{"subject": "UBERON:0000410", "predicate": "biolink:correlated_with", "object": "GO:0070254", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06767_MESH_D003139_1", "DB06767_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000410", "original_object": "GO:0070254"}
{"subject": "UMLS:C0017890", "predicate": "biolink:treats", "object": "HP:0012735", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00145_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005998", "original_object": "MESH:D003371"}
{"subject": "UBERON:0004755", "predicate": "biolink:develops_from", "object": "CL:0007001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004755", "original_object": "CL:0007001"}
{"subject": "UMLS:C1136325", "predicate": "biolink:increases_sensitivity_to", "object": "NCBIGene:3605", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "NCBITaxon:10090", "publications": ["PMID:30853428"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D039741", "original_object": "NCBIGENE:3605"}
{"subject": "MP:0004045", "predicate": "biolink:affects", "object": "GO:0000075", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MP:0004045", "original_object": "GO:0000075"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0000403", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00443_MESH_D012536_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "UBERON:0000403"}
{"subject": "CHEBI:82405", "predicate": "biolink:regulates", "object": "NCBITaxon:1747", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09096_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D001585", "original_object": "NCBITaxon:1747"}
{"subject": "MONDO:0018310", "predicate": "biolink:disrupts", "object": "CL:0000453", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0018310", "original_object": "CL:0000453"}
{"subject": "GO:0002154", "predicate": "biolink:affects", "object": "NCBIGene:116519", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00451_MESH_D006949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0002154", "original_object": "UniProtKB:Q6Q788"}
{"subject": "CHEBI:65265", "predicate": "biolink:negatively_correlated_with", "object": "GO:0001696", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09481_MESH_D003248_1", "DB09481_MESH_D004415_1", "DB09481_MESH_D005764_1", "DB09481_MESH_D006356_1", "DB09481_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000863", "original_object": "GO:0001696"}
{"subject": "GO:0003943", "predicate": "biolink:affects", "object": "CHEBI:18085", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01279_MESH_D009087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0003943", "original_object": "MESH:D006025"}
{"subject": "NCBIGene:4509", "predicate": "biolink:genetically_associated_with", "object": "NCBIGene:4509", "primary_knowledge_source": "infores:uniprot", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC:7415", "original_object": "OMIM:516070"}
{"subject": "UBERON:0034929", "predicate": "biolink:overlaps", "object": "CL:0000540", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0034929", "original_object": "CL:0000540"}
{"subject": "UBERON:0001913", "predicate": "biolink:has_part", "object": "CHEBI:18059", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001913", "original_object": "CHEBI:18059"}
{"subject": "GO:0051607", "predicate": "biolink:affects", "object": "NCBITaxon:333922", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00724_MESH_D055623_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0051607", "original_object": "NCBITaxon:333922"}
{"object": "NCBIGene:2562", "predicate": "biolink:has_participant", "subject": "HP:0003470", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00592_MESH_D001196_1", "DB00592_MESH_D017229_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P28472", "original_subject": "HP:0003470"}
{"subject": "MONDO:0005044", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005098", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00966_MESH_D020521_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006973", "original_object": "MESH:D020521"}
{"subject": "GO:0006068", "predicate": "biolink:has_input", "object": "CHEBI:16236", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006068", "original_object": "CHEBI:16236"}
{"subject": "CHEBI:83379", "predicate": "biolink:has_part", "object": "CHEBI:83382", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:83379", "original_object": "CHEBI:83382"}
{"subject": "CHEBI:32090", "predicate": "biolink:negatively_correlated_with", "object": "CHEBI:26519", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11656_MESH_D005756_1", "DB11656_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C052785", "original_object": "MESH:D005609"}
{"subject": "GO:0035240", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00420_MESH_D011618_1", "DB00420_MESH_D012559_1", "DB00420_MESH_D019958_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0035240", "original_object": "MESH:D004298"}
{"subject": "NCBIGene:2099", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:50114", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04574_MESH_D059268_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P03372", "original_object": "MESH:D004967"}
{"subject": "CHEBI:141517", "predicate": "biolink:capable_of", "object": "GO:0043129", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06439_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C016811", "original_object": "GO:0043129"}
{"subject": "UMLS:C0657912", "predicate": "biolink:causes", "object": "UMLS:C0438215", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00230", "original_object": "UMLS:C0438215"}
{"subject": "NCBIGene:5241", "predicate": "biolink:correlated_with", "object": "UMLS:C0042404", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P06401", "original_object": "MESH:D014666"}
{"subject": "GO:0035805", "predicate": "biolink:coexists_with", "object": "CL:0000025", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0035805", "original_object": "CL:0000025"}
{"subject": "UBERON:0000955", "predicate": "biolink:affects", "object": "CHEBI:15514", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D008881_1", "DB00313_MESH_D008881_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "UBERON:0000955", "original_object": "MESH:C026563"}
{"subject": "GO:0038169", "predicate": "biolink:regulates", "object": "MONDO:0019933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06791_MESH_D000172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0038169", "original_object": "MESH:D000172"}
{"subject": "MESH:D044062", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB07615_MESH_D003876_2", "DB07615_MESH_D065631_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D044062", "original_object": "GO:0006954"}
{"subject": "NCBIGene:1240", "predicate": "biolink:in_complex_with", "object": "NCBIGene:2778", "primary_knowledge_source": "infores:signor", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:39616240"], "description": ["Altogether, our findings suggest that the CBR1 interactions between CMKLR1 and chemerin is responsible for stabilizing the chemerin-CMKLR1 complex, which allows the efficient insertion of the C-terminus of chemerin into the orthosteric binding pocket of CMKLR1 for receptor activation and downstream G protein signaling."], "species_context_qualifier": "NCBITaxon:9606", "original_subject": "UniProtKB:Q99788", "original_object": "UniProtKB:P63092"}
{"subject": "GO:0060087", "predicate": "biolink:ameliorates_condition", "object": "HP:0001681", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00335_MESH_D000787_1", "DB01020_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060087", "original_object": "MESH:D000787"}
{"object": "UBERON:0001062", "predicate": "biolink:has_part", "subject": "NCBITaxon:7227", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "FBbt:10000000", "original_subject": "NCBITaxon:7227"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "PANTHER.FAMILY:PTHR10078", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08895_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "PANTHER.FAMILY:PTHR10078"}
{"subject": "NCBIGene:4306", "predicate": "biolink:positively_correlated_with", "object": "HGNC.FAMILY:1203", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D065446_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08235", "original_object": "HGNC.FAMILY:1203"}
{"subject": "UMLS:C1517336", "predicate": "biolink:affects", "object": "NCBIGene:7015", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UMLS:C1517336", "original_object": "UniProtKB:O14746"}
{"subject": "GO:0043083", "predicate": "biolink:correlated_with", "object": "MONDO:0005146", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01104_MESH_D013313_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0043083", "original_object": "MESH:D013313"}
{"subject": "HGNC.FAMILY:245", "predicate": "biolink:negatively_correlated_with", "object": "GO:0060004", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00318_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:245", "original_object": "GO:0060004"}
{"subject": "CHEBI:35441", "predicate": "biolink:ameliorates_condition", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03255_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000890", "original_object": "MESH:D011537"}
{"subject": "UMLS:C0042774", "predicate": "biolink:positively_correlated_with", "object": "UMLS:C0282629", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09102_MESH_D019698_1", "DB09296_MESH_D019698_1", "DB11613_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0042774", "original_object": "UMLS:C0282629"}
{"subject": "UBERON:0010210", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0000831", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00266_MESH_D013927_1", "DB00946_MESH_D013927_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010210", "original_object": "MESH:D013927"}
{"subject": "CL:0001074", "predicate": "biolink:has_part", "object": "NCBIGene:4684", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0001074", "original_object": "PR:P13591"}
{"subject": "NCBIGene:153", "predicate": "biolink:regulates", "object": "GO:1990454", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00264_MESH_D000787_1", "DB00264_MESH_D009203_1", "DB00264_MESH_D054058_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P08588", "original_object": "GO:1990454"}
{"subject": "UMLS:C1511448", "predicate": "biolink:subclass_of", "object": "UMLS:C1511449", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C22627", "original_object": "NCIT:C22626"}
{"subject": "MONDO:0044348", "predicate": "biolink:has_participant", "object": "CHEBI:35143", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0044348", "original_object": "CHEBI:35143"}
{"subject": "GO:0030485", "predicate": "biolink:subclass_of", "object": "CL:0008007", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000192", "original_object": "CL:0008007"}
{"subject": "CHEBI:18295", "predicate": "biolink:regulates", "object": "GO:0071159", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00434_MESH_D065631_1", "DB01114_MESH_D065631_1", "DB04837_MESH_D012220_1", "DB04837_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D006632", "original_object": "GO:0071159"}
{"subject": "CHEBI:6942", "predicate": "biolink:produces", "object": "CL:0000346", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00350_MESH_D000505_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008914", "original_object": "CL:0000346"}
{"subject": "PUBCHEM.COMPOUND:10255482", "predicate": "biolink:disrupts", "object": "GO:0032774", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09256_MESH_D013274_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C025635", "original_object": "GO:0032774"}
{"subject": "CHEBI:32190", "predicate": "biolink:produces", "object": "CHEBI:9436", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11783_MESH_D006973_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C055603", "original_object": "MESH:C069156"}
{"subject": "GO:0007213", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:15355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00508_MESH_D011618_3", "DB00508_MESH_D011618_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007213", "original_object": "MESH:D000109"}
{"subject": "CHEBI:7959", "predicate": "biolink:capable_of", "object": "GO:0046911", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00859_MESH_D001172_2", "DB00859_MESH_D003555_2", "DB00859_MESH_D006527_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010396", "original_object": "GO:0046911"}
{"subject": "GO:0046930", "predicate": "biolink:located_in", "object": "GO:0030445", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002179_1", "DB00646_MESH_D002180_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0008915", "original_object": "GO:0030445"}
{"subject": "UNII:15G12L5X8K", "predicate": "biolink:causes", "object": "UMLS:C0438215", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00743", "original_object": "UMLS:C0438215"}
{"subject": "NCBITaxon:2", "predicate": "biolink:causes", "object": "HP:0200042", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05245_MESH_D012883_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:2", "original_object": "MESH:D012883"}
{"subject": "CL:0000062", "predicate": "biolink:affects", "object": "CHEBI:196519", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11093_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D010006", "original_object": "MESH:D053244"}
{"object": "MONDO:0006231", "predicate": "biolink:causes", "subject": "UBERON:0005409", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0006231", "original_subject": "UBERON:0005409"}
{"subject": "UBERON:0000123", "predicate": "biolink:coexists_with", "object": "GO:0043209", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000123", "original_object": "GO:0043209"}
{"subject": "GO:0016209", "predicate": "biolink:preventative_for_condition", "object": "HP:0025610", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00137_MESH_D000080343_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0016209", "original_object": "MESH:D000080343"}
{"subject": "GO:0042310", "predicate": "biolink:negatively_correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00449_MESH_D005902_1", "DB00668_MESH_D005902_1", "DB00668_MESH_D005902_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042310", "original_object": "UBERON:0001796"}
{"subject": "CHEBI:65265", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D005744", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09104_MESH_D004415_1", "DB09104_MESH_D005764_1", "DB09104_MESH_D006356_1", "DB09104_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000863", "original_object": "MESH:D005744"}
{"subject": "CHEBI:17303", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005010", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00295", "original_object": "DOID:3393"}
{"subject": "MONDO:0016648", "predicate": "biolink:affects", "object": "HP:0002656", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002654", "original_object": "HP:0002656"}
{"subject": "GO:0008237", "predicate": "biolink:affects", "object": "GO:0031012", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00287_MESH_D005902_1", "DB00287_MESH_D009798_1", "DB00654_MESH_D005902_1", "DB00654_MESH_D009798_1", "DB08819_MESH_D005902_1", "DB08819_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0008237", "original_object": "GO:0031012"}
{"subject": "NCBIGene:3565", "predicate": "biolink:genetically_associated_with", "object": "UMLS:C0035234", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:6014", "original_object": "UMLS:C0035234"}
{"subject": "HGNC.FAMILY:245", "predicate": "biolink:affects", "object": "CHEBI:16480", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00295_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "HGNC.FAMILY:245", "original_object": "CHEBI:16480"}
{"subject": "HGNC.FAMILY:180", "predicate": "biolink:treats", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00835_MESH_D011537_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:180", "original_object": "MESH:D011537"}
{"object": "GO:0051262", "predicate": "biolink:disrupts", "subject": "GO:0043243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05352_MESH_D000686_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0051262", "original_subject": "GO:0043243"}
{"subject": "CHEBI:31889", "predicate": "biolink:negatively_correlated_with", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12447_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C062127", "original_object": "UBERON:0001866"}
{"subject": "GO:0005618", "predicate": "biolink:positively_correlated_with", "object": "GO:0051301", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01000_MESH_D001991_1", "DB01000_MESH_D010612_1", "DB01000_MESH_D014552_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005618", "original_object": "GO:0051301"}
{"subject": "NCBIGene:2099", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:50114", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00882_MESH_D007247_1", "DB04938_MESH_D004414_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P03372", "original_object": "MESH:D004967"}
{"subject": "HP:0031377", "predicate": "biolink:located_in", "object": "CL:0000236", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00997_MESH_D008224_1", "DB00997_MESH_D016403_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0031377", "original_object": "CL:0000236"}
{"subject": "GO:0070254", "predicate": "biolink:related_to", "object": "HP:0031245", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06767_MESH_D003139_1", "DB06767_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0070254", "original_object": "HP:0031245"}
{"subject": "UMLS:C1518774", "predicate": "biolink:subclass_of", "object": "UMLS:C0208355", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C13336", "original_object": "NCIT:C13314"}
{"subject": "MESH:C019248", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:52255", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00282_MESH_C562390_1", "DB00282_MESH_D010001_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C019248", "original_object": "CHEBI:52255"}
{"subject": "CHEBI:28694", "predicate": "biolink:positively_correlated_with", "object": "PANTHER.FAMILY:PTHR10078", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D003300", "original_object": "PANTHER.FAMILY:PTHR10078"}
{"subject": "NCBIGene:847", "predicate": "biolink:genetically_associated_with", "object": "UMLS:C0022650", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:1516", "original_object": "UMLS:C0022650"}
{"subject": "CL:0000198", "predicate": "biolink:contributes_to", "object": "GO:0019233", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06691_MESH_D004412_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000198", "original_object": "GO:0019233"}
{"subject": "UBERON:0012364", "predicate": "biolink:has_part", "object": "PR:000016283", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0012364", "original_object": "PR:000016283"}
{"subject": "GO:0006972", "predicate": "biolink:regulates", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00742_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0006972", "original_object": "UBERON:0001796"}
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{"subject": "CHEBI:77035", "predicate": "biolink:affects", "object": "UBERON:0016553", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00874_MESH_D003139_1", "DB00874_MESH_D012220_1", "DB00874_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D005100", "original_object": "UBERON:0016553"}
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{"subject": "NCBIGene:1128", "predicate": "biolink:regulates", "object": "UBERON:0001044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00424_MESH_D012798_1", "DB00986_MESH_D012798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P11229", "original_object": "UBERON:0001044"}
{"subject": "UBERON:0001896", "predicate": "biolink:regulates", "object": "MONDO:0005709", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00327_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0001896", "original_object": "MESH:D003139"}
{"subject": "GO:0006915", "predicate": "biolink:temporally_related_to", "object": "GO:0097190", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006915", "original_object": "GO:0097190"}
{"subject": "UMLS:C0280508", "predicate": "biolink:related_to", "object": "UMLS:C0022687", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C10246", "original_object": "NCIT:C13008"}
{"subject": "GO:0007259", "predicate": "biolink:positively_correlated_with", "object": "REACT:R-HSA-1169410", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00105_MESH_C554498_1", "DB00105_MESH_D003218_1", "DB00105_MESH_D019694_1", "DB00105_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007259", "original_object": "REACT:R-HSA-1169410"}
{"subject": "MESH:D015021", "predicate": "biolink:produces", "object": "UMLS:C2607955", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D015021", "original_object": "UMLS:C2607955"}
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{"subject": "GO:0016125", "predicate": "biolink:disrupts", "object": "UMLS:C0025245", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D004827_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-211976", "original_object": "UMLS:C0025245"}
{"subject": "MONDO:0005530", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005530", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01433_MESH_D009293_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0033515", "original_object": "MESH:D009293"}
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{"subject": "CHEBI:39501", "predicate": "biolink:disrupts", "object": "CHEBI:28694", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_2", "DB06824_MESH_D002292_3", "DB06824_MESH_D006527_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014266", "original_object": "MESH:D003300"}
{"subject": "NCBIGene:7046", "predicate": "biolink:affects", "object": "REACT:R-HSA-381377", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activation", "subject_context_qualifier": "UniProtKB:P01137", "anatomical_context_qualifier": "UMLS:C0334227", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:33731701"], "primary_knowledge_source": "infores:ccidb", "original_subject": "UniProtKB:P36897", "original_object": "REACT:R-HSA-381377"}
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{"subject": "CHEBI:7003", "predicate": "biolink:has_part", "object": "CHEBI:17303", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:7003", "original_object": "CHEBI:17303"}
{"subject": "CHEBI:3314", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0022650", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4433", "original_object": "UMLS:C0022650"}
{"subject": "GO:0030548", "predicate": "biolink:causes", "object": "GO:0099565", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030548", "original_object": "GO:0099565"}
{"subject": "CHEBI:26519", "predicate": "biolink:disrupts", "object": "HP:0011355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00855_MESH_D055623_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005609", "original_object": "HP:0011355"}
{"subject": "UMLS:C0051846", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:64628", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06791_MESH_D000172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C060347", "original_object": "MESH:D013004"}
{"subject": "GO:0005764", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0002561", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01279_MESH_D009087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005764", "original_object": "MESH:D016464"}
{"subject": "CHEBI:136004", "predicate": "biolink:produces", "object": "CHEBI:16480", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09282_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C002385", "original_object": "MESH:D009569"}
{"subject": "UMLS:C0022818", "predicate": "biolink:contributes_to", "object": "UBERON:2000006", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:35687267"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D007737", "original_object": "MESH:D015452"}
{"subject": "CL:0000317", "predicate": "biolink:affects", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00655_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "CL:0000317", "original_object": "MESH:D012629"}
{"subject": "GO:0071159", "predicate": "biolink:affects", "object": "NCBIGene:7412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00806_MESH_D016491_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0071159", "original_object": "UniProtKB:P19320"}
{"subject": "GO:0006260", "predicate": "biolink:positively_correlated_with", "object": "CL:0001063", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01030_MESH_D010051_1", "DB01030_MESH_D055752_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006260", "original_object": "CL:0001063"}
{"subject": "PANTHER.FAMILY:PTHR22935", "predicate": "biolink:preventative_for_condition", "object": "GO:0018104", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01333_MESH_D012141_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR22935", "original_object": "GO:0018104"}
{"subject": "UNII:8680B21W73", "predicate": "biolink:diagnoses", "object": "UMLS:C1720505", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5271", "original_object": "UMLS:C1720505"}
{"subject": "UBERON:0003956", "predicate": "biolink:correlated_with", "object": "HP:0007906", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13165_MESH_D005901_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003956", "original_object": "HP:0007906"}
{"subject": "HGNC.FAMILY:181", "predicate": "biolink:correlated_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01621_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:181", "original_object": "MESH:D004298"}
{"object": "UniProtKB:P18177", "predicate": "biolink:produces", "subject": "NCBITaxon:1496", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13140_MESH_D003015_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P18177", "original_subject": "NCBITaxon:1496"}
{"subject": "CHEBI:41977", "predicate": "biolink:contributes_to", "object": "GO:0140713", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00694_MESH_D004915_1", "DB00694_MESH_D007948_1", "DB00694_MESH_D012514_1", "DB00694_MESH_D015470_1", "DB00694_MESH_D015473_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D003630", "original_object": "GO:0140713"}
{"subject": "GO:0015842", "predicate": "biolink:positively_correlated_with", "object": "REACT:R-HSA-212676", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04844_MESH_D006816_1", "DB11915_MESH_D000071057_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015842", "original_object": "REACT:R-HSA-212676"}
{"subject": "UMLS:C0032015", "predicate": "biolink:manifestation_of", "object": "MONDO:0005090", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00623_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010907", "original_object": "MESH:D012559"}
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{"subject": "ComplexPortal:CPX-1070", "predicate": "biolink:acts_upstream_of_positive_effect", "object": "GO:0098990", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:20395454"], "original_subject": "ComplexPortal:CPX-1070", "original_object": "GO:0098990"}
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{"subject": "NCBIGene:155", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:4846", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04861_MESH_D006973_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P13945", "original_object": "UniProtKB:P29474"}
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{"subject": "REACT:R-HSA-556833", "predicate": "biolink:disrupts", "object": "UMLS:C0025245", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D004827_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-556833", "original_object": "UMLS:C0025245"}
{"object": "CHEBI:75316", "predicate": "biolink:derives_from", "subject": "MESH:D010648", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08909_MESH_D056806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CHEBI:75316", "original_subject": "MESH:D010648"}
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{"subject": "MESH:C515501", "predicate": "biolink:has_metabolite", "object": "CHEBI:70729", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06590_MESH_D004927_1", "DB06590_MESH_D011018_1", "DB06590_MESH_D012226_1", "DB06590_MESH_D013203_1", "DB06590_MESH_D013290_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C515501", "original_object": "CHEBI:70729"}
{"subject": "UBERON:0003902", "predicate": "biolink:develops_from", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003902", "original_object": "NCBITaxon:6072"}
{"subject": "UNII:RRW32X4U1F", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:50114", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00890_MESH_D004414_1", "DB00890_MESH_D059268_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004028", "original_object": "MESH:D004967"}
{"subject": "UNII:1B56C968OA", "predicate": "biolink:affects", "object": "CL:0000057", "qualified_predicate": "biolink:causes", "subject_context_qualifier": "UniProtKB:P09619", "anatomical_context_qualifier": "UMLS:C1512505", "disease_context_qualifier": "MONDO:0007254", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:31419632"], "primary_knowledge_source": "infores:ccidb", "original_subject": "UNII:1B56C968OA", "original_object": "CL:0000057"}
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{"subject": "NCBIGene:3558", "predicate": "biolink:produces", "object": "CL:0000084", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11693_MESH_D014605_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P60568", "original_object": "CL:0000084"}
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{"subject": "REACT:R-HSA-2162123", "predicate": "biolink:has_output", "object": "CHEBI:15627", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00945_MESH_D013927_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-2162123", "original_object": "MESH:D013928"}
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{"subject": "UniProtKB:Q72547", "predicate": "biolink:expressed_in", "object": "GO:0039693", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00495_MESH_D015658_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q72547", "original_object": "GO:0039693"}
{"subject": "GO:0001696", "predicate": "biolink:regulates", "object": "HGNC.FAMILY:1927", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06724_MESH_D004415_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0001696", "original_object": "HGNC.FAMILY:1927"}
{"subject": "UMLS:C0877880", "predicate": "biolink:coexists_with", "object": "MESH:D015021", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C422802", "original_object": "MESH:D015021"}
{"subject": "CHEBI:65023", "predicate": "biolink:contributes_to", "object": "UBERON:0002190", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:10852428"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D018927", "original_object": "MESH:D015434"}
{"object": "UBERON:3010328", "predicate": "biolink:has_part", "subject": "CL:0000365", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:3010328", "original_subject": "CL:0000365"}
{"subject": "UBERON:0004033", "predicate": "biolink:coexists_with", "object": "GO:0098846", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004033", "original_object": "GO:0098846"}
{"subject": "CHEBI:36386", "predicate": "biolink:affects", "object": "MONDO:0000153", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:27518881"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D003999", "original_object": "MESH:D014188"}
{"subject": "CHEBI:5291", "predicate": "biolink:subclass_of", "object": "CHEBI:60004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:5291", "original_object": "CHEBI:60004"}
{"subject": "MESH:C045463", "predicate": "biolink:has_metabolite", "object": "CHEBI:68540", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01097_MESH_D001172_1", "DB01097_MESH_D015535_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C045463", "original_object": "MESH:C527525"}
{"subject": "UBERON:0010427", "predicate": "biolink:correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01210_MESH_D005902_1", "DB01210_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010427", "original_object": "UBERON:0001796"}
{"subject": "MESH:C547738", "predicate": "biolink:coexists_with", "object": "UMLS:C1565020", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08870_MESH_D006689_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C547738", "original_object": "MESH:C495575"}
{"subject": "UMLS:C0002563", "predicate": "biolink:causes", "object": "UMLS:C0205204", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00855", "original_object": "UMLS:C0205204"}
{"object": "GO:0009274", "predicate": "biolink:has_part", "subject": "NCBITaxon:2", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05245_MESH_D012883_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0009274", "original_subject": "NCBITaxon:2"}
{"object": "CHEBI:18295", "predicate": "biolink:has_participant", "subject": "MONDO:0007817", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00748_MESH_D003233_2", "DB00748_MESH_D006255_1", "DB00748_MESH_D065631_1", "DB01075_MESH_D003233_1", "DB01075_MESH_D006255_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:D006632", "original_subject": "MESH:D006969"}
{"subject": "GO:0007197", "predicate": "biolink:affects", "object": "MESH:D005744", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00725_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0007197", "original_object": "MESH:D005744"}
{"subject": "UBERON:0001796", "predicate": "biolink:regulates", "object": "HP:0007906", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01210_MESH_D009798_3", "DB01210_MESH_D009798_4", "DB06826_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0001796", "original_object": "HP:0007906"}
{"subject": "CHEBI:25029", "predicate": "biolink:correlated_with", "object": "GO:0043303", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00972_MESH_D003233_1", "DB00972_MESH_D006255_1", "DB00972_MESH_D012223_1", "DB00972_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:25029", "original_object": "GO:0043303"}
{"subject": "CHEBI:18243", "predicate": "biolink:located_in", "object": "UBERON:0035999", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00268_MESH_D010300_1", "DB00413_MESH_D010300_1", "DB00714_MESH_D010300_1", "DB01200_MESH_D010300_1", "DB01200_MESH_D010301_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004298", "original_object": "UBERON:0035999"}
{"subject": "UMLS:C0041014", "predicate": "biolink:similar_to", "object": "CHEBI:6485", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00279", "original_object": "DRUGBANK:DB01583"}
{"subject": "GO:0001698", "predicate": "biolink:overlaps", "object": "GO:0007186", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001698", "original_object": "GO:0007186"}
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{"subject": "UBERON:0010210", "predicate": "biolink:predisposes_to_condition", "object": "HP:0001907", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00266_MESH_D013923_1", "DB00946_MESH_D013923_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010210", "original_object": "MESH:D013923"}
{"subject": "CHEBI:142437", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0039986", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2995", "original_object": "UMLS:C0039986"}
{"subject": "REACT:R-HSA-390651", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005090", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13676_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-390651", "original_object": "MESH:D012559"}
{"subject": "CHEBI:15443", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0022650", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1447", "original_object": "UMLS:C0022650"}
{"subject": "HP:0001257", "predicate": "biolink:negatively_correlated_with", "object": "GO:0022414", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00848_MESH_D000724_1", "DB00848_MESH_D001196_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001257", "original_object": "GO:0022414"}
{"subject": "CHEBI:16933", "predicate": "biolink:contributes_to", "object": "GO:0009277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06636_MESH_D001228_1", "DB06636_MESH_D009091_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16933", "original_object": "GO:0009277"}
{"subject": "CHEBI:17489", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00195_MESH_D005902_1", "DB00195_MESH_D009798_1", "DB00484_MESH_D005902_2", "DB00484_MESH_D009798_2", "DB00521_MESH_D005902_1", "DB00521_MESH_D009798_1", "DB09351_MESH_D005902_1", "DB09351_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17489", "original_object": "UBERON:0001796"}
{"subject": "UNII:S866O45PIG", "predicate": "biolink:chemically_similar_to", "object": "UBERON:0008826", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06761_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C072197", "original_object": "UBERON:0008826"}
{"subject": "CHEBI:15443", "predicate": "biolink:subclass_of", "object": "CHEBI:28645", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:15443", "original_object": "CHEBI:29084"}
{"subject": "GO:0008213", "predicate": "biolink:disrupts", "object": "UMLS:C1136102", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03843_MESH_D007251_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008213", "original_object": "UMLS:C1136102"}
{"subject": "GO:0000305", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00911_MESH_D005873_1", "DB00911_MESH_D008101_1", "DB00911_MESH_D014245_1", "DB00911_MESH_D016585_1", "DB11989_MESH_D014355_1", "DB12834_MESH_D005873_1", "DB12834_MESH_D014245_1", "DB12834_MESH_D016585_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000305", "original_object": "MESH:D004247"}
{"subject": "CHEBI:16236", "predicate": "biolink:correlated_with", "object": "NCBIGene:5310", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:18215696", "PMID:21389975"], "original_subject": "HMDB:HMDB0000108", "original_object": "OMIM:601313"}
{"subject": "CHEBI:50580", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0030163", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:237", "original_object": "UMLS:C0030163"}
{"subject": "GO:0007212", "predicate": "biolink:has_participant", "object": "CL:0000700", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007212", "original_object": "CL:0000700"}
{"subject": "MESH:C008976", "predicate": "biolink:chemically_similar_to", "object": "MESH:D012597", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06811_MESH_D014648_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C008976", "original_object": "MESH:D012597"}
{"subject": "GO:0098666", "predicate": "biolink:related_to", "object": "CHEBI:32952", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098666", "original_object": "CHEBI:32952"}
{"subject": "GO:0008283", "predicate": "biolink:precedes", "object": "CL:0001063", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04845_MESH_D001943_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008283", "original_object": "CL:0001063"}
{"subject": "HGNC.FAMILY:181", "predicate": "biolink:negatively_correlated_with", "object": "HP:0002071", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01186_MESH_D020734_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:181", "original_object": "HP:0002071"}
{"subject": "GO:0004714", "predicate": "biolink:regulates", "object": "HP:0031377", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01254_MESH_D001752_1", "DB01254_MESH_D015466_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004714", "original_object": "HP:0031377"}
{"subject": "NCBIGene:5468", "predicate": "biolink:directly_physically_interacts_with", "object": "HGNC.FAMILY:2086", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P37231", "original_object": "HGNC.FAMILY:2086"}
{"subject": "UBERON:0025525", "predicate": "biolink:negatively_correlated_with", "object": "HP:0030895", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08890_MESH_D043183_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0025525", "original_object": "HP:0030895"}
{"subject": "UMLS:C1172636", "predicate": "biolink:disrupts", "object": "CHEBI:8005", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06219_MESH_D013207_1", "DB06219_MESH_D017192_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C469289", "original_object": "CHEBI:8005"}
{"subject": "REACT:R-HSA-70171", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5833", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00468_MESH_D016778_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-70171", "original_object": "NCBITaxon:5833"}
{"subject": "CHEBI:7566", "predicate": "biolink:produces", "object": "CHEBI:26523", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11820_MESH_D014355_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009547", "original_object": "CHEBI:26523"}
{"subject": "MONDO:0004992", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "NCBIGene:213", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5602453", "PMC:9053164"], "tmkp_confidence_score": 0.2376184596187509, "sentences": "Compared to other singular treatment groups, P@-Gem-HSA-NPs (L+) showed a highly synergistic effect in destructing cancer cells by in vitro of combined PDT and chemotherapy (P<0.05).|NA|The greater therapeutic efficiency of CTAC@MSNs-HSA is mainly attributed to the presence of HSA, which increase the cell uptake of nanomaterials and improve their biocompatibility, thus provide the prolonged cytotoxicity of nanomaterials against cancer cells.|NA", "tmkp_ids": ["tmkp:1acfe86ef33199d48c9ac06fad51f1920786bbdfb9cd770915c4e40870282a08", "tmkp:5272965de4ad6fe3443e0d85771f30656c98ea423b21852c97ea5ea3111ee866"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "MONDO:0004992", "original_object": "DRUGBANK:DB00062"}