{"subject": "NCBITaxon:1661386", "predicate": "biolink:subclass_of", "object": "NCBITaxon:286", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1661386", "original_object": "NCBITaxon:286", "id": "0000001671844790"}
{"subject": "PUBCHEM.COMPOUND:44274699", "predicate": "biolink:affects", "object": "NCBIGene:5770", "ligand": "PUBCHEM.COMPOUND:44274699", "protein": "UniProtKB:P18031", "affinity_parameter": "pIC50", "supporting_affinities": [6.89], "publications": ["PMID:10753467"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 6.89, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:44274699", "original_object": "UniProtKB:P18031", "object_aspect_qualifier": "activity", "object_direction_qualifier": "decreased", "qualified_predicate": "biolink:causes", "id": "000000bf725377b1"}
{"subject": "PUBCHEM.COMPOUND:44274699", "predicate": "biolink:affects", "object": "NCBIGene:5770", "ligand": "PUBCHEM.COMPOUND:44274699", "protein": "UniProtKB:P18031", "affinity_parameter": "pIC50", "supporting_affinities": [6.89], "publications": ["PMID:10753467"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 6.89, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:44274699", "original_object": "UniProtKB:P18031", "object_aspect_qualifier": "activity", "object_direction_qualifier": "decreased", "qualified_predicate": "biolink:causes", "id": "000000bf725377b1"}
{"subject": "NCBITaxon:1706470", "predicate": "biolink:related_to", "object": "NCBITaxon:1706470", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1706470", "original_object": "NCBITaxon:1706470", "id": "0000013b5e1daf8f"}
{"subject": "NCBIGene:3458", "predicate": "biolink:actively_involved_in", "object": "GO:0006913", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["NCBI gene2go"], "original_subject": "NCBIGene:3458", "original_object": "GO:0006913", "id": "000001c0b56ee179"}
{"subject": "NCBIGene:3458", "predicate": "biolink:actively_involved_in", "object": "GO:0006913", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["NCBI gene2go"], "original_subject": "NCBIGene:3458", "original_object": "GO:0006913", "id": "000001c0b56ee179"}
{"subject": "UniProtKB:Q9R0M5-1", "predicate": "biolink:subclass_of", "object": "CHEBI:33579", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:Q9R0M5-1", "original_object": "CHEBI:33579", "id": "000001e031404130"}
{"subject": "CHEBI:68579", "predicate": "biolink:contributes_to", "object": "MONDO:0002251", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5156547", "PMC:2730547", "PMC:5003057"], "tmkp_confidence_score": 0.6128887859621844, "sentences": "Aside from bleeding, some of the additional side effects of rivaroxaban include the following: dizziness (6%), peripheral edema (6%), hypersensitivity reactions or rash (2%), syncope (2%), and though more rare, thrombocytopenia, agranulocytosis, hepatitis, pruritis, and Stevens?Johnson syndrome.|NA|In the third patient, rivaroxaban was stopped after 23 d, when hepatitis B with seroconversion was diagnosed; the patient died of acute liver failure, mostly due to fatal hepatitis B infection, 48 d after starting treatment.|NA|Non-hemorrhagic adverse effects of rivaroxaban in the EINSTEIN-EXT study were upper abdominal pain, dyspepsia, sinusitis, tooth ache, UTI, back pain and fatigue (all less than 5%) whereas post marketing voluntary reporting of adverse effects include anaphylaxis, angioedema, Stevens-Johnson syndrome, agranulocytosis, jaundice and hepatitis.|NA", "tmkp_ids": ["tmkp:21709dfe811f66a9f620d41080651d41e3d1d379af32db099f3d5a7b494bb6cb", "tmkp:fd2d3e43f75ceac886f3de1b65395369865a1648efc1371ea27bc5b724668584", "tmkp:a62f721434da7ccccc0aee9c2709dc7e571c1caea24237d2ce5dee0cb76a9958"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB06228", "original_object": "MONDO:0002251", "id": "0000021b3546412c"}
{"subject": "CHEBI:68579", "predicate": "biolink:contributes_to", "object": "MONDO:0002251", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5156547", "PMC:2730547", "PMC:5003057"], "tmkp_confidence_score": 0.6128887859621844, "sentences": "Aside from bleeding, some of the additional side effects of rivaroxaban include the following: dizziness (6%), peripheral edema (6%), hypersensitivity reactions or rash (2%), syncope (2%), and though more rare, thrombocytopenia, agranulocytosis, hepatitis, pruritis, and Stevens?Johnson syndrome.|NA|In the third patient, rivaroxaban was stopped after 23 d, when hepatitis B with seroconversion was diagnosed; the patient died of acute liver failure, mostly due to fatal hepatitis B infection, 48 d after starting treatment.|NA|Non-hemorrhagic adverse effects of rivaroxaban in the EINSTEIN-EXT study were upper abdominal pain, dyspepsia, sinusitis, tooth ache, UTI, back pain and fatigue (all less than 5%) whereas post marketing voluntary reporting of adverse effects include anaphylaxis, angioedema, Stevens-Johnson syndrome, agranulocytosis, jaundice and hepatitis.|NA", "tmkp_ids": ["tmkp:21709dfe811f66a9f620d41080651d41e3d1d379af32db099f3d5a7b494bb6cb", "tmkp:fd2d3e43f75ceac886f3de1b65395369865a1648efc1371ea27bc5b724668584", "tmkp:a62f721434da7ccccc0aee9c2709dc7e571c1caea24237d2ce5dee0cb76a9958"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB06228", "original_object": "MONDO:0002251", "id": "0000021b3546412c"}
{"subject": "NCBIGene:836088", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:836392", "primary_knowledge_source": "infores:intact", "publications": "PMID:30806640", "detection_method": "MI:0892", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UniProtKB:Q9FN94", "original_object": "UniProtKB:Q8GX94", "id": "0000022338cc7ec7"}
{"subject": "NCBIGene:836088", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:836392", "primary_knowledge_source": "infores:intact", "publications": "PMID:30806640", "detection_method": "MI:0892", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UniProtKB:Q9FN94", "original_object": "UniProtKB:Q8GX94", "id": "0000022338cc7ec7"}
{"subject": "NCBIGene:836088", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:836392", "primary_knowledge_source": "infores:intact", "publications": "PMID:30806640", "detection_method": "MI:0892", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UniProtKB:Q9FN94", "original_object": "UniProtKB:Q8GX94", "id": "0000022338cc7ec7"}
{"subject": "NCBIGene:836088", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:836392", "primary_knowledge_source": "infores:intact", "publications": "PMID:30806640", "detection_method": "MI:0892", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UniProtKB:Q9FN94", "original_object": "UniProtKB:Q8GX94", "id": "0000022338cc7ec7"}
{"subject": "NCBITaxon:2390634", "predicate": "biolink:subclass_of", "object": "UBERON:0001062", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:2390634", "original_object": "UBERON:0001062", "id": "000002d920943dd8"}
{"subject": "CHEBI:114566", "predicate": "biolink:subclass_of", "object": "CHEBI:38166", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:114566", "original_object": "CHEBI:38166", "id": "0000039642fdc6ee"}
{"subject": "NCBIGene:1376", "predicate": "biolink:affects", "object": "PUBCHEM.COMPOUND:131757099", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P23786", "original_object": "HMDB:HMDB0046150", "object_aspect_qualifier": "abundance", "id": "000003ce09273b8c"}
{"subject": "NCBIGene:1376", "predicate": "biolink:affects", "object": "PUBCHEM.COMPOUND:131757099", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P23786", "original_object": "HMDB:HMDB0046150", "object_aspect_qualifier": "abundance", "id": "000003ce09273b8c"}
{"object": "CHEBI:29888", "predicate": "biolink:has_participant", "subject": "SMPDB:SMP0048300", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HMDB:HMDB0000250", "original_subject": "SMPDB:SMP0048300", "id": "000005a611bed6b8"}
{"object": "CHEBI:29888", "predicate": "biolink:has_participant", "subject": "SMPDB:SMP0048300", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HMDB:HMDB0000250", "original_subject": "SMPDB:SMP0048300", "id": "000005a611bed6b8"}
{"subject": "NCBIGene:4539", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:4728", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000354728", "original_object": "ENSEMBL:ENSP00000315774", "id": "00000a79ac760ee3"}
{"subject": "NCBIGene:4539", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:4728", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000354728", "original_object": "ENSEMBL:ENSP00000315774", "id": "00000a79ac760ee3"}
{"subject": "NCBIGene:4539", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:4728", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000354728", "original_object": "ENSEMBL:ENSP00000315774", "id": "00000a79ac760ee3"}
{"subject": "NCBIGene:4539", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:4728", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000354728", "original_object": "ENSEMBL:ENSP00000315774", "id": "00000a79ac760ee3"}
{"subject": "UBERON:0001709", "predicate": "biolink:overlaps", "object": "UBERON:0001434", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001709", "original_object": "UBERON:0001434", "id": "00000ddaf453ee40"}
{"subject": "UMLS:C3536740", "predicate": "biolink:subclass_of", "object": "UMLS:C3273258", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C101202", "original_object": "NCIT:C97151", "id": "00000efaddf02a6a"}
{"subject": "NCBIGene:856756", "predicate": "biolink:subclass_of", "object": "CHEBI:50860", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:P40022", "original_object": "CHEBI:50860", "id": "000013980cc937cb"}
{"object": "REACT:R-PFA-77108", "predicate": "biolink:occurs_in", "subject": "REACT:R-PFA-74181", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-PFA-77108", "original_subject": "REACT:R-PFA-74181", "id": "000014b0cecd29c4"}
{"subject": "NCBIGene:100153047", "predicate": "biolink:expressed_in", "object": "CL:0000023", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "not_provided", "id": "00001519731ac228", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "provided_by": "bgee_gene_to_expression_edges", "original_subject": "NCBIGene:100153047", "original_object": "CL:0000023"}
{"subject": "NCBIGene:100153047", "predicate": "biolink:expressed_in", "object": "CL:0000023", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "not_provided", "id": "00001519731ac228", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "provided_by": "bgee_gene_to_expression_edges", "original_subject": "NCBIGene:100153047", "original_object": "CL:0000023"}
{"subject": "NCBIGene:534965", "predicate": "biolink:expressed_in", "object": "UBERON:0001158", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "not_provided", "id": "00001d69c9873ecc", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "provided_by": "bgee_gene_to_expression_edges", "original_subject": "NCBIGene:534965", "original_object": "UBERON:0001158"}
{"subject": "NCBIGene:534965", "predicate": "biolink:expressed_in", "object": "UBERON:0001158", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "not_provided", "id": "00001d69c9873ecc", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "provided_by": "bgee_gene_to_expression_edges", "original_subject": "NCBIGene:534965", "original_object": "UBERON:0001158"}
{"subject": "NCBIGene:388", "predicate": "biolink:regulates", "object": "NCBIGene:1058", "primary_knowledge_source": "infores:lincs", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "NCBIGene:388", "original_object": "NCBIGene:1058", "id": "00001edcf93cbc65"}
{"subject": "NCBIGene:388", "predicate": "biolink:regulates", "object": "NCBIGene:1058", "primary_knowledge_source": "infores:lincs", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "NCBIGene:388", "original_object": "NCBIGene:1058", "id": "00001edcf93cbc65"}
{"subject": "NCBIGene:388", "predicate": "biolink:regulates", "object": "NCBIGene:1058", "primary_knowledge_source": "infores:lincs", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "NCBIGene:388", "original_object": "NCBIGene:1058", "id": "00001edcf93cbc65"}
{"subject": "NCBIGene:388", "predicate": "biolink:regulates", "object": "NCBIGene:1058", "primary_knowledge_source": "infores:lincs", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "NCBIGene:388", "original_object": "NCBIGene:1058", "id": "00001edcf93cbc65"}
{"subject": "NCBIGene:4998", "predicate": "biolink:affects", "object": "NCBIGene:80725", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5747948"], "tmkp_confidence_score": 0.95192146, "sentences": "Upregulated molecules include ANLN, BLM, BNIP3, BRIP1, BUB1, C5orf22, CA9, CCDC6, CDC25A, CDC45, CENPU, CEP72, CHRNA5, CKS2, DDT, DGKD, DMBT1, E2f, E2F1, EIF4EBP1 (alias 4EBP1), ESRP2, EXOSC4, GPR26, GSDMB, HN1, LLGL2, KNL1 (CASC5), MYCN, NUSAP1, ORC1, PFKP, RAD51, RAD54L, RAP1GAP, RASGRF1, RDH10, RRAGD, RPL13A (SNORD34, SNORD35A), RPLP2 (SNORA52), RPS2 (SNORA10), RSP3 (SNORD15A), S100A7, S100A7A, S100A9, SGO1 (SGOL1), SLC25A19, SPRY4, SRCIN1, STK3, TBX20, TRIB3, TTK, UBE2S, and XRCC2.|NA", "tmkp_ids": ["tmkp:11b4e21e75c5fceb42be5a2ecdf229087a67c91b0f3f0267462950ebf0b08339"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "UniProtKB:Q13415", "original_object": "UniProtKB:Q9C0H9", "id": "000021b45d145c0e"}
{"subject": "NCBIGene:4998", "predicate": "biolink:affects", "object": "NCBIGene:80725", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5747948"], "tmkp_confidence_score": 0.95192146, "sentences": "Upregulated molecules include ANLN, BLM, BNIP3, BRIP1, BUB1, C5orf22, CA9, CCDC6, CDC25A, CDC45, CENPU, CEP72, CHRNA5, CKS2, DDT, DGKD, DMBT1, E2f, E2F1, EIF4EBP1 (alias 4EBP1), ESRP2, EXOSC4, GPR26, GSDMB, HN1, LLGL2, KNL1 (CASC5), MYCN, NUSAP1, ORC1, PFKP, RAD51, RAD54L, RAP1GAP, RASGRF1, RDH10, RRAGD, RPL13A (SNORD34, SNORD35A), RPLP2 (SNORA52), RPS2 (SNORA10), RSP3 (SNORD15A), S100A7, S100A7A, S100A9, SGO1 (SGOL1), SLC25A19, SPRY4, SRCIN1, STK3, TBX20, TRIB3, TTK, UBE2S, and XRCC2.|NA", "tmkp_ids": ["tmkp:11b4e21e75c5fceb42be5a2ecdf229087a67c91b0f3f0267462950ebf0b08339"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "UniProtKB:Q13415", "original_object": "UniProtKB:Q9C0H9", "id": "000021b45d145c0e"}
{"subject": "NCBIGene:4998", "predicate": "biolink:affects", "object": "NCBIGene:80725", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5747948"], "tmkp_confidence_score": 0.95192146, "sentences": "Upregulated molecules include ANLN, BLM, BNIP3, BRIP1, BUB1, C5orf22, CA9, CCDC6, CDC25A, CDC45, CENPU, CEP72, CHRNA5, CKS2, DDT, DGKD, DMBT1, E2f, E2F1, EIF4EBP1 (alias 4EBP1), ESRP2, EXOSC4, GPR26, GSDMB, HN1, LLGL2, KNL1 (CASC5), MYCN, NUSAP1, ORC1, PFKP, RAD51, RAD54L, RAP1GAP, RASGRF1, RDH10, RRAGD, RPL13A (SNORD34, SNORD35A), RPLP2 (SNORA52), RPS2 (SNORA10), RSP3 (SNORD15A), S100A7, S100A7A, S100A9, SGO1 (SGOL1), SLC25A19, SPRY4, SRCIN1, STK3, TBX20, TRIB3, TTK, UBE2S, and XRCC2.|NA", "tmkp_ids": ["tmkp:11b4e21e75c5fceb42be5a2ecdf229087a67c91b0f3f0267462950ebf0b08339"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "UniProtKB:Q13415", "original_object": "UniProtKB:Q9C0H9", "id": "000021b45d145c0e"}
{"subject": "NCBIGene:4998", "predicate": "biolink:affects", "object": "NCBIGene:80725", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5747948"], "tmkp_confidence_score": 0.95192146, "sentences": "Upregulated molecules include ANLN, BLM, BNIP3, BRIP1, BUB1, C5orf22, CA9, CCDC6, CDC25A, CDC45, CENPU, CEP72, CHRNA5, CKS2, DDT, DGKD, DMBT1, E2f, E2F1, EIF4EBP1 (alias 4EBP1), ESRP2, EXOSC4, GPR26, GSDMB, HN1, LLGL2, KNL1 (CASC5), MYCN, NUSAP1, ORC1, PFKP, RAD51, RAD54L, RAP1GAP, RASGRF1, RDH10, RRAGD, RPL13A (SNORD34, SNORD35A), RPLP2 (SNORA52), RPS2 (SNORA10), RSP3 (SNORD15A), S100A7, S100A7A, S100A9, SGO1 (SGOL1), SLC25A19, SPRY4, SRCIN1, STK3, TBX20, TRIB3, TTK, UBE2S, and XRCC2.|NA", "tmkp_ids": ["tmkp:11b4e21e75c5fceb42be5a2ecdf229087a67c91b0f3f0267462950ebf0b08339"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "UniProtKB:Q13415", "original_object": "UniProtKB:Q9C0H9", "id": "000021b45d145c0e"}
{"subject": "HGNC.FAMILY:1561", "predicate": "biolink:has_part", "object": "NCBIGene:10296", "primary_knowledge_source": "infores:hgnc", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:9763581"], "original_subject": "HGNC.FAMILY:1561", "original_object": "HGNC:13731", "id": "000024a2d188566b"}
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{"subject": "PANTHER.FAMILY:PTHR22884:SF473", "predicate": "biolink:actively_involved_in", "object": "GO:2001141", "primary_knowledge_source": "infores:panther", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR22884:SF473", "original_object": "GO:2001141", "id": "000024ae71db678d"}
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{"subject": "CHEBI:6909", "predicate": "biolink:causes", "object": "MONDO:0005020", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00916", "original_object": "UMLS:C0021831", "id": "000178e7b5022b67"}
{"subject": "UniProtKB:Q8BX79-1", "predicate": "biolink:subclass_of", "object": "NCBIGene:338346", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:Q8BX79-1", "original_object": "PR:Q8BX79", "id": "00017f107f9a0b3b"}
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{"subject": "CHEBI:36009", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0005267", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9113147", "PMC:4431415"], "tmkp_confidence_score": 0.5388464144180738, "sentences": "Some oils are also nutritionally important due to their requirement in a healthy diet including long-chain omega-3 and omega-6 fatty acids which have functions that help prevent heart disease and stroke (R?os-Covi?n et al.,).|NA|Furthermore, EPUFAs such as omega-3 and omega-6 fatty acids have important effects on the body, particularly relevant to enhancing appropriate pre- and postnatal development (mainly of the central and peripheral nervous systems), lowering cholesterol and triglyceride levels, reducing acute and chronic inflammation, treating patients with neurodegenerative disorders, contributing to blood pressure regulation, and reducing the odds of developing cancer, heart disease, and stroke.|NA", "tmkp_ids": ["tmkp:37dfbae222f18b02ab7dbcef8a1e2e484d06b585634ad7e8aa9bea767d72670f", "tmkp:b60a7e5818bb5934267b44b245e3c129299efee36a60f966a07c15c1eceaf367"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB13168", "original_object": "MONDO:0005267", "id": "0001b899397a21f8"}
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{"subject": "NCBIGene:6839", "predicate": "biolink:correlated_with", "object": "NCBIGene:51310", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["ERC"], "original_subject": "NCBIGene:6839", "original_object": "NCBIGene:51310", "id": "0001c889e57463e1"}
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{"subject": "CHEBI:8389", "predicate": "biolink:has_adverse_event", "object": "MONDO:0013600", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 72.091, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4855", "original_object": "MEDDRA:10022437", "id": "00023e6491793fee"}
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{"subject": "CHEBI:167638", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0271149", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1531", "original_object": "UMLS:C0271149", "id": "0002f42c7c749dea"}
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{"subject": "CHEBI:43522", "predicate": "biolink:subclass_of", "object": "CHEBI:26151", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:43522", "original_object": "CHEBI:26151", "id": "00032e75cb0f01bf"}
{"subject": "REACT:R-CFA-9756138", "predicate": "biolink:has_output", "object": "CHEBI:180932", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-CFA-9756138", "original_object": "CHEBI:180932", "id": "00037c792e15931f"}
{"subject": "REACT:R-SSC-9728150", "predicate": "biolink:has_input", "object": "NCBIGene:100286743", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SSC-9728150", "original_object": "UniProtKB:A0A5G2R5M2", "id": "0003950eb56f6cd4"}
{"subject": "CHEBI:50729", "predicate": "biolink:contributes_to", "object": "HP:0002013", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:10597740", "PMID:11851027", "PMID:15333686"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008942", "original_object": "MESH:D014839", "id": "0003d2dc879fb48e"}
{"subject": "CHEBI:50729", "predicate": "biolink:contributes_to", "object": "HP:0002013", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:10597740", "PMID:11851027", "PMID:15333686"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008942", "original_object": "MESH:D014839", "id": "0003d2dc879fb48e"}
{"subject": "CHEBI:3207", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0002783", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:7708268", "PMC:7708268", "PMC:7708268"], "tmkp_confidence_score": 0.9865026, "sentences": "Budesonide/formoterol significantly reduces the frequency of these events versus formoterol alone, without an associated increase in the rate of LRTI and pneumonia.|NA|Finally, we assess whether therapy with budesonide/formoterol versus formoterol alone can reduce the frequency of, and outcomes associated with, COPD symptom-related attacks, and whether this addition of an inhaled corticosteroid (ICS) to a long-acting ?2-agonist (LABA) is associated with an increased incidence of lower respiratory tract infections (LRTI) and pneumonia.|NA|In addition to highlighting the incidence and importance of COPD symptom-related attacks, our analysis also showed that adding budesonide to formoterol significantly reduces the frequency of these attacks versus formoterol alone, without the increased risk of LRTI or pneumonia.|NA", "tmkp_ids": ["tmkp:8a00e41fc8ab25edc0b73ee2df14171a9a85d036a97261e177e600e8c936111c", "tmkp:63ffc9358890913b843d836527a07b7f8bb7f8112483f4184271ea6dec6b7444", "tmkp:02732dba589fa52d1e62ebfe15ab2ce76860307bd5e97a1287347fc86611ab98"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB01222", "original_object": "HP:0002783", "id": "0003f004400927a1"}
{"subject": "CHEBI:3207", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0002783", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:7708268", "PMC:7708268", "PMC:7708268"], "tmkp_confidence_score": 0.9865026, "sentences": "Budesonide/formoterol significantly reduces the frequency of these events versus formoterol alone, without an associated increase in the rate of LRTI and pneumonia.|NA|Finally, we assess whether therapy with budesonide/formoterol versus formoterol alone can reduce the frequency of, and outcomes associated with, COPD symptom-related attacks, and whether this addition of an inhaled corticosteroid (ICS) to a long-acting ?2-agonist (LABA) is associated with an increased incidence of lower respiratory tract infections (LRTI) and pneumonia.|NA|In addition to highlighting the incidence and importance of COPD symptom-related attacks, our analysis also showed that adding budesonide to formoterol significantly reduces the frequency of these attacks versus formoterol alone, without the increased risk of LRTI or pneumonia.|NA", "tmkp_ids": ["tmkp:8a00e41fc8ab25edc0b73ee2df14171a9a85d036a97261e177e600e8c936111c", "tmkp:63ffc9358890913b843d836527a07b7f8bb7f8112483f4184271ea6dec6b7444", "tmkp:02732dba589fa52d1e62ebfe15ab2ce76860307bd5e97a1287347fc86611ab98"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB01222", "original_object": "HP:0002783", "id": "0003f004400927a1"}
{"subject": "REACT:R-BTA-75864", "predicate": "biolink:has_output", "object": "CHEBI:29888", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-BTA-75864", "original_object": "KEGG.COMPOUND:C00013", "id": "00040f0fd072c348"}
{"subject": "CHEBI:34764", "predicate": "biolink:has_adverse_event", "object": "HP:0001155", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 547.154, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1198", "original_object": "MEDDRA:10061194", "id": "00041940bba381df"}
{"subject": "CHEBI:34764", "predicate": "biolink:has_adverse_event", "object": "HP:0001155", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 547.154, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1198", "original_object": "MEDDRA:10061194", "id": "00041940bba381df"}
{"subject": "NCBIGene:6927", "predicate": "biolink:genetically_associated_with", "object": "HP:0012051", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:11621", "original_object": "UMLS:C0271710", "id": "00042f34fa86366f"}
{"subject": "NCBIGene:6927", "predicate": "biolink:genetically_associated_with", "object": "HP:0012051", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:11621", "original_object": "UMLS:C0271710", "id": "00042f34fa86366f"}
{"subject": "REACT:R-MMU-2022065", "predicate": "biolink:subclass_of", "object": "GO:0009306", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-MMU-2022065", "original_object": "GO:0009306", "id": "00043296ab194fcc"}
{"subject": "GO:0030845", "predicate": "biolink:subclass_of", "object": "GO:0065007", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030845", "original_object": "GO:0065007", "id": "000433ffa2794c92"}
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{"subject": "PUBCHEM.COMPOUND:44422696", "predicate": "biolink:related_to", "object": "NCBIGene:1132", "ligand": "PUBCHEM.COMPOUND:44422696", "protein": "UniProtKB:P08173", "affinity_parameter": "pKi", "supporting_affinities": [4.34], "publications": ["PMID:18077164"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 4.34, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:44422696", "original_object": "UniProtKB:P08173", "id": "0017b34c455a7815"}
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{"subject": "NCBIGene:213", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0010604", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5269444", "PMC:5269444", "PMC:7467451", "PMC:7467451", "PMC:8362221"], "tmkp_confidence_score": 0.7510764686879398, "sentences": "These results demonstrate improved correction of hemophilia B using AAV vectors pre-incubated with HSA, and also suggest possible utilization of this formulation to increase efficacy at lower vector doses for the treatment of hemophilia and other diseases.|NA|Improved phenotypic correction of hemophilia B using human albumin to enhance AAV vector transduction|NA|An extended half-life fusion protein linking recombinant FIX (rFIX) with human albumin (rIX-FP) has been developed for the treatment of patients with haemophilia B and is indicated for dosing up to every 14?days.|NA|This study looked at the use of an extended half-life fusion protein linking recombinant FIX (rFIX) with human albumin (rIX-FP), which was designed to allow longer dosing intervals, in patients with haemophilia B in Italy, Belgium and the UK, and compared this with the patients? previous FIX product.|NA|The short half?life of coagulation factor IX (FIX) for haemophilia B (HB) therapy has been prolonged through fusion with human serum albumin (HSA), which drives the neonatal Fc receptor (FcRn)?mediated recycling of the chimera.|NA", "tmkp_ids": ["tmkp:ea6077357b87d83e75591a3f05a9b23dfbd36bd2bef7d5d6b1ed1b6f7f413490", "tmkp:c5fe9040a43a41e353ab8e1292a19f77db8d07a1965b97337c673d0bf92e545d", "tmkp:6d51739a0b3e8896689128e28e893c10dbce882dc01c65e0b1eb8384f65239aa", "tmkp:808d4496d401416444223e8287801d6655880b5113d86b2dae8910afa8dde67c", "tmkp:aaea7629bde1e50035ac706ae62a60850a01f58825ec1e574a59f55a85c95925"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00062", "original_object": "MONDO:0010604", "id": "0017c99bffdd54a5"}
{"subject": "CHEBI:25944", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005093", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:15858460", "PMID:11665844"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010575", "original_object": "MESH:D012871", "id": "0017ea2a672a6d51"}
{"subject": "UNII:9JD9B4S53T", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0016262", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9180633", "PMC:9180633", "PMC:9180633", "PMC:9180633", "PMC:9180633"], "tmkp_confidence_score": 0.99948324, "sentences": "In uLMS cells, DAPT and MK-0752 decreased Notch signaling in a dose- and time-dependent manner.|NA|DAPT and MK-0752 Decrease uLMS Cell Viability|NA|Taken together, our findings demonstrate that DAPT is more effective than MK-0752 at reducing Notch signaling activity in uLMS cells, but neither GSI decreases uLMS cell proliferation or invasion, which are required for tumor progression.|NA|Exposure of SK-UT-1B and SK-LMS-1 to DAPT and MK-0752 decreased expression of HES1 and decreased uLMS cell viability in a dose- and time-dependent manner that was unique to each GSI.|NA|MK-0752, which is orally tolerated, should be investigated in 3D in vitro and in vivo models, either alone or in combination with other cytotoxic agents, to further assess efficacy as a potential therapeutic modality against uLMS.|NA", "tmkp_ids": ["tmkp:0de2a52300f83b6d5675b2a02cee3342ffd764a64aca30dcc03f9df683f8d5c2", "tmkp:8344109c65dc7c3507b03184fd603ac5810550e4c9d10a46ae01eb96055e0cde", "tmkp:8c95a620a9fb15757b97abb9d50d5962e4b9fa528d19577a5f9223259be5d136", "tmkp:481fc3bd2a5b21b43d1ff52a7a15108af83ba3d13671910a3767527119dce62a", "tmkp:0838bc6be36003f53ad506104e1c69a64a23a9ad4f07b6a79615833b66decf44"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB12852", "original_object": "HP:0002891", "id": "0017f90a20776217"}
{"subject": "GO:0009532", "predicate": "biolink:in_taxon", "object": "NCBITaxon:131567", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009532", "original_object": "NCBITaxon:131567", "id": "001927ccedaa2d8d"}
{"subject": "CHEBI:91829", "predicate": "biolink:regulates", "object": "NCBIGene:55859", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:22565", "original_object": "HGNC:1036", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes", "id": "0019d4c0187cd701"}
{"subject": "CHEBI:91829", "predicate": "biolink:regulates", "object": "NCBIGene:55859", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:22565", "original_object": "HGNC:1036", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes", "id": "0019d4c0187cd701"}
{"subject": "NCBIGene:3565", "predicate": "biolink:increases_response_to", "object": "MESH:D052638", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "NCBITaxon": "10090", "publications": ["PMID:10550748"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:3565", "original_object": "MESH:D052638", "id": "001a2aaec2361e5c"}
{"subject": "NCBIGene:3565", "predicate": "biolink:increases_response_to", "object": "MESH:D052638", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "NCBITaxon": "10090", "publications": ["PMID:10550748"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:3565", "original_object": "MESH:D052638", "id": "001a2aaec2361e5c"}
{"subject": "UNII:C3574QBZ3Y", "predicate": "biolink:contributes_to", "object": "EFO:0009426", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:24503009"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C028007", "original_object": "MESH:D009336", "id": "001a89568961fa0e"}
{"subject": "GO:0015765", "predicate": "biolink:has_input", "object": "CHEBI:60982", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015765", "original_object": "CHEBI:60982", "id": "001b4f83ee5ccc9c"}
{"subject": "UNII:Q5EN532NE7", "predicate": "biolink:preventative_for_condition", "object": "GO:0090592", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01280_MESH_D054218_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C022206", "original_object": "GO:0090592", "id": "001b838fd5079093"}
{"subject": "CHEBI:119915", "predicate": "biolink:causes", "object": "UMLS:C0235146", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00813", "original_object": "UMLS:C0235146", "id": "001bad35a91faaa6"}
{"subject": "CHEBI:119915", "predicate": "biolink:causes", "object": "UMLS:C0235146", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00813", "original_object": "UMLS:C0235146", "id": "001bad35a91faaa6"}
{"subject": "GO:0030073", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002909", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01016_MESH_D003924_1", "DB00731_MESH_D003924_1", "DB00672_MESH_D003924_1", "DB01289_MESH_D003924_1", "DB00222_MESH_D003924_1", "DB08962_MESH_D003924_1", "DB01124_MESH_D003924_1", "DB01120_MESH_D003924_1", "DB00839_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030073", "original_object": "HP:0003074", "id": "001be644d3514588"}
{"subject": "UBERON:0034876", "predicate": "biolink:develops_from", "object": "UBERON:0006240", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0034876", "original_object": "UBERON:0006240", "id": "001bf7d838abc755"}
{"subject": "UBERON:0009975", "predicate": "biolink:related_to", "object": "GO:0050877", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0009975", "original_object": "GO:0050877", "id": "001c86c56d701e06"}
{"subject": "MONDO:0002367", "predicate": "biolink:similar_to", "object": "MONDO:0005089", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["MEDLINE cooccurrence"], "original_subject": "DOID:263", "original_object": "DOID:1115", "id": "001c8cd81e73d580"}
{"subject": "UBERON:0002233", "predicate": "biolink:related_to", "object": "UBERON:0002276", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002233", "original_object": "UBERON:0002276", "id": "001d720a19a4d3aa"}
{"subject": "CHEBI:102265", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0032981", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2502", "original_object": "UMLS:C0032981", "id": "001def1daf112ad3"}
{"subject": "CHEBI:5134", "predicate": "biolink:subclass_of", "object": "CHEBI:77166", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:74899", "original_object": "CHEBI:77166", "id": "001e13d4fdd0e00c"}
{"subject": "MONDO:0100096", "predicate": "biolink:has_part", "object": "NCBIGene:59272", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "complex_context": ["S1:ACE2", "S1 trimer:ACE2:S2 trimer", "Spike trimer:ACE2", "S3:M:E:encapsidated  SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs", "S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2"], "original_subject": "DOID:0080600", "original_object": "UniProtKB:Q9BYF1", "id": "001e406fa70efe37"}
{"subject": "MONDO:0100096", "predicate": "biolink:has_part", "object": "NCBIGene:59272", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "complex_context": ["S1:ACE2", "S1 trimer:ACE2:S2 trimer", "Spike trimer:ACE2", "S3:M:E:encapsidated  SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs", "S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2"], "original_subject": "DOID:0080600", "original_object": "UniProtKB:Q9BYF1", "id": "001e406fa70efe37"}
{"subject": "CHEBI:180472", "predicate": "biolink:subclass_of", "object": "CHEBI:17996", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:180472", "original_object": "CHEBI:23114", "id": "001e498375a1765b"}
{"subject": "CHEBI:3398", "predicate": "biolink:contraindicated_in", "object": "HP:0200119", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:499", "original_object": "UMLS:C0267797", "id": "001f8fb3c62e38f4"}
{"subject": "CL:0000920", "predicate": "biolink:related_to", "object": "UBERON:0000077", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000920", "original_object": "UBERON:0000077", "id": "0021234654061e85"}
{"subject": "GO:0051958", "predicate": "biolink:has_input", "object": "CHEBI:50681", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0051958", "original_object": "CHEBI:50681", "id": "00240703280c3013"}
{"subject": "UMLS:C5555759", "predicate": "biolink:affects", "object": "UBERON:0012332", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C179547", "original_object": "NCIT:C12318", "id": "00244bfd9800cac8"}
{"object": "MONDO:0000306", "predicate": "biolink:causes", "subject": "NCBITaxon:5552", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0000306", "original_subject": "NCBITaxon:5552", "id": "00247b469696ca96"}
{"subject": "CHEBI:49662", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005178", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00328", "original_object": "DOID:8398", "id": "002514ea5d75c714"}
{"subject": "CHEBI:49662", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005178", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00328", "original_object": "DOID:8398", "id": "002514ea5d75c714"}
{"subject": "GO:0019226", "predicate": "biolink:related_to", "object": "GO:0045202", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019226", "original_object": "GO:0045202", "id": "0025a41949ba2687"}
{"subject": "CHEBI:8481", "predicate": "biolink:causes", "object": "UMLS:C0039971", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00782", "original_object": "UMLS:C0039971", "id": "00260117e267ca79"}
{"subject": "CHEBI:8481", "predicate": "biolink:causes", "object": "UMLS:C0039971", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00782", "original_object": "UMLS:C0039971", "id": "00260117e267ca79"}
{"subject": "GO:0047533", "predicate": "biolink:has_participant", "object": "CHEBI:15377", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0047533", "original_object": "CHEBI:15377", "id": "002647900ce5703f"}
{"subject": "GO:0009273", "predicate": "biolink:occurs_in", "object": "NCBITaxon:139", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01112_MESH_D008193_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009273", "original_object": "NCBITaxon:139", "id": "0026763f41acbdf0"}
{"subject": "REACT:R-HSA-201035", "predicate": "biolink:has_input", "object": "CHEBI:15756", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-201035", "original_object": "KEGG.COMPOUND:C00249", "id": "0026ab44eb64bd05"}
{"subject": "MONDO:0002095", "predicate": "biolink:related_to", "object": "UMLS:C1708871", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C7390", "original_object": "NCIT:C47834", "id": "00276e99ea84d5b2"}
{"subject": "REACT:R-BTA-75244", "predicate": "biolink:subclass_of", "object": "GO:0097190", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-BTA-75244", "original_object": "GO:0097190", "id": "002829da4d93dffd"}
{"subject": "CHEBI:17561", "predicate": "biolink:similar_to", "object": "CHEBI:15729", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00151", "original_object": "DRUGBANK:DB00129", "id": "002966e5671de0cd"}
{"subject": "CHEBI:51700", "predicate": "biolink:subclass_of", "object": "HP:0000118", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:51700", "original_object": "HP:0000118", "id": "002b7137a452253c"}
{"subject": "CL:4033038", "predicate": "biolink:related_to", "object": "GO:0007585", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4033038", "original_object": "GO:0007585", "id": "002bf33620fbbca9"}
{"subject": "UMLS:C2826229", "predicate": "biolink:contributes_to", "object": "HP:0003326", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6601617"], "tmkp_confidence_score": 1.2497003426605344, "sentences": "Adverse events occurring more frequently in the ado-trastuzumab emtansine group than in the lapatinib plus capecitabine group included thrombo-cytopenia (31% vs 3%), constipation (27% vs 11%), increased amino transferase levels (29% vs 14%), headache (28% vs 15%), epistaxis (23% vs 8%), arthralgia (19% vs 8%), pyrexia (19% vs 8%), dry mouth (17% vs 5%), and myalgia (14% vs 4%).|NA", "tmkp_ids": ["tmkp:8fdf1c841e8c1bcd215311f8d96f2953f8e11c41f38a9d3dbbc763e3f572d21c"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB05773", "original_object": "HP:0003326", "id": "002c371748a6b614"}
{"subject": "UMLS:C1515454", "predicate": "biolink:subclass_of", "object": "UBERON:0000475", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C40046", "original_object": "NCIT:C32221", "id": "002c6b9a68bc8c2e"}
{"subject": "GO:0150034", "predicate": "biolink:temporally_related_to", "object": "GO:0007275", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0150034", "original_object": "GO:0007275", "id": "002d19748bb7d415"}
{"subject": "MONDO:0021641", "predicate": "biolink:related_to", "object": "NCBITaxon:1980416", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0021641", "original_object": "NCBITaxon:1980416", "id": "002e58f4b7ac1c2a"}
{"subject": "CHEBI:82451", "predicate": "biolink:associated_with_increased_likelihood_of", "object": "MONDO:0005059", "primary_knowledge_source": "infores:cebs", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["TR:TR-128"], "anatomical_context_qualifier": "UBERON:0002193", "sex_qualifier": "male", "species_context_qualifier": "NCBITaxon:10116", "population_context_qualifier": "RGD:13506918", "original_subject": "INCHIKEY:QZWKEPYTBWZJJA-UHFFFAOYSA-N", "original_object": "DOID:1240", "id": "002eaa76e3030af9"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0015758", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00959_MESH_D009182_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "HP:0012192", "id": "002f7d7a60de1fb8"}
{"subject": "CHEBI:133354", "predicate": "biolink:has_part", "object": "CHEBI:133353", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:133354", "original_object": "CHEBI:133353", "id": "0030ff100860fc49"}
{"subject": "HP:0012465", "predicate": "biolink:occurs_in", "object": "MONDO:0019402", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01609_MESH_D017086_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012465", "original_object": "MESH:D017086", "id": "0031058102690e6d"}
{"subject": "CL:1000147", "predicate": "biolink:develops_from", "object": "UBERON:0000948", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:1000147", "original_object": "UBERON:0000948", "id": "0032194918f4b5f5"}
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{"subject": "CHEBI:27834", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0032961", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2098", "original_object": "UMLS:C0032961", "id": "00aacc82a98c3b36"}
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{"subject": "NCBIGene:596", "predicate": "biolink:decreases_response_to", "object": "CHEBI:60831", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "NCBITaxon": "9606", "publications": ["PMID:12517783"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:596", "original_object": "MESH:D034261", "id": "00ab14273ee2076c"}
{"subject": "NCBIGene:596", "predicate": "biolink:decreases_response_to", "object": "CHEBI:60831", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "NCBITaxon": "9606", "publications": ["PMID:12517783"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:596", "original_object": "MESH:D034261", "id": "00ab14273ee2076c"}
{"subject": "NCBIGene:401024", "predicate": "biolink:acts_upstream_of_or_within_positive_effect", "object": "GO:0007288", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:30745215", "PMID:30137358"], "original_subject": "UniProtKB:Q5CZC0", "original_object": "GO:0007288", "id": "00ab48ed6731398e"}
{"subject": "NCBIGene:401024", "predicate": "biolink:acts_upstream_of_or_within_positive_effect", "object": "GO:0007288", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:30745215", "PMID:30137358"], "original_subject": "UniProtKB:Q5CZC0", "original_object": "GO:0007288", "id": "00ab48ed6731398e"}
{"subject": "MONDO:0001898", "predicate": "biolink:affects", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000610", "original_object": "NCBITaxon:6072", "id": "00ab4fd5537ada7d"}
{"subject": "GO:1990257", "predicate": "biolink:develops_from", "object": "UBERON:0016880", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990257", "original_object": "UBERON:0016880", "id": "00ac47712d306ba9"}
{"subject": "GO:0022016", "predicate": "biolink:occurs_in", "object": "UBERON:0000955", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0022016", "original_object": "UBERON:0000955", "id": "00bd5f3969c528c0"}
{"subject": "GO:0071897", "predicate": "biolink:correlated_with", "object": "GO:0008283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00791_MESH_D008228_1", "DB00791_MESH_D015451_1", "DB00791_MESH_D015464_1", "DB00791_MESH_D011087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071897", "original_object": "GO:0008283", "id": "00c293a224faf1bd"}
{"subject": "GO:0034188", "predicate": "biolink:precedes", "object": "GO:0009987", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0034188", "original_object": "GO:0009987", "id": "00c701e731143a38"}
{"subject": "CL:0000091", "predicate": "biolink:located_in", "object": "UBERON:0000949", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000091", "original_object": "UBERON:0000949", "id": "00c7d1bb0225c9e1"}
{"object": "GO:0033360", "predicate": "biolink:has_participant", "subject": "CHEBI:58117", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0033360", "original_subject": "CHEBI:58117", "id": "00cdd6e4082a00c9"}
{"object": "CHEBI:17627", "predicate": "biolink:has_participant", "subject": "SMPDB:SMP0000220", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HMDB:HMDB0003178", "original_subject": "SMPDB:SMP0000220", "id": "00cdd81c6c4683b9"}
{"subject": "CHEBI:76358", "predicate": "biolink:has_part", "object": "CHEBI:76358", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:76359", "original_object": "CHEBI:76358", "id": "00d1a476ed949239"}
{"subject": "GO:0015720", "predicate": "biolink:has_input", "object": "CHEBI:15676", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015720", "original_object": "CHEBI:15676", "id": "00d575cdf3597757"}
{"object": "GO:0030876", "predicate": "biolink:has_participant", "subject": "GO:0071345", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0030876", "original_subject": "GO:0071345", "id": "00d5a1a009cb7e66"}
{"subject": "NCBIGene:254531", "predicate": "biolink:regulates", "object": "CHEBI:15346", "primary_knowledge_source": "infores:metabolomics_workbench", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "HGNC:30059", "original_object": "PUBCHEM.COMPOUND:87642", "id": "00dab340f3d80e9e"}
{"subject": "NCBIGene:254531", "predicate": "biolink:regulates", "object": "CHEBI:15346", "primary_knowledge_source": "infores:metabolomics_workbench", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "HGNC:30059", "original_object": "PUBCHEM.COMPOUND:87642", "id": "00dab340f3d80e9e"}
{"subject": "GO:0070434", "predicate": "biolink:regulates", "object": "GO:0070431", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0070434", "original_object": "GO:0070431", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes", "id": "00dbf83898e400da"}
{"subject": "CL:4052014", "predicate": "biolink:in_taxon", "object": "NCBITaxon:7776", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4052014", "original_object": "NCBITaxon:7776", "id": "00dcc4bc7c64df66"}
{"subject": "CHEBI:16526", "predicate": "biolink:correlated_with", "object": "HP:0001950", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00819_MESH_D000532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002245", "original_object": "HP:0001950", "id": "00dea5bde76db2a4"}
{"subject": "CHEBI:16526", "predicate": "biolink:correlated_with", "object": "HP:0001950", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00819_MESH_D000532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002245", "original_object": "HP:0001950", "id": "00dea5bde76db2a4"}
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{"subject": "CHEBI:33744", "predicate": "biolink:has_part", "object": "CHEBI:33356", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:33744", "original_object": "CHEBI:33356", "id": "00e66964f70c06f7"}
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{"subject": "CL:0000921", "predicate": "biolink:related_to", "object": "CHEBI:24402", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000921", "original_object": "CHEBI:24402", "id": "00e85fb6c198794e"}
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{"subject": "NCBIGene:6580", "predicate": "biolink:located_in", "object": "UBERON:0008404", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:O15245", "original_object": "UBERON:0008404", "id": "00ea16cb449ec2cc"}
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{"subject": "NCBIGene:5743", "predicate": "biolink:target_for", "object": "HP:0002315", "drugmechdb_path_id": ["DB09213_MESH_D006261_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "primary_knowledge_source": "infores:drugmechdb", "original_subject": "UniProtKB:P35354", "original_object": "MESH:D006261", "id": "00f403d055ecdbfd"}
{"subject": "NCBIGene:5743", "predicate": "biolink:target_for", "object": "HP:0002315", "drugmechdb_path_id": ["DB09213_MESH_D006261_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "primary_knowledge_source": "infores:drugmechdb", "original_subject": "UniProtKB:P35354", "original_object": "MESH:D006261", "id": "00f403d055ecdbfd"}
{"subject": "CHEBI:132833", "predicate": "biolink:subclass_of", "object": "CHEBI:60911", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:132833", "original_object": "CHEBI:60911", "id": "00f47003ec6402d3"}
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{"subject": "CHEBI:75736", "predicate": "biolink:subclass_of", "object": "CHEBI:60004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:75736", "original_object": "CHEBI:60004", "id": "00f6eaea8291f336"}
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{"subject": "CHEBI:7494", "predicate": "biolink:causes", "object": "UMLS:C1142135", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01149", "original_object": "UMLS:C1142135", "id": "00fa474baf6c6c3c"}
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{"subject": "GO:0071036", "predicate": "biolink:overlaps", "object": "GO:0010467", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071036", "original_object": "GO:0010467", "id": "00fa5db8b6b8e4a9"}
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{"subject": "NCBIGene:150", "predicate": "biolink:correlated_with", "object": "MONDO:0002009", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06148_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08913", "original_object": "MESH:D003865", "id": "010d696ace0864d9"}
{"subject": "UNII:DJX4AL4ENX", "predicate": "biolink:positively_correlated_with", "object": "GO:0035861", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01262_MESH_D015470_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PUBCHEM.COMPOUND:126357", "original_object": "GO:0035861", "id": "010ff80ab65f4b50"}
{"subject": "HP:0002938", "predicate": "biolink:has_part", "object": "MONDO:0003280", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002938", "original_object": "HP:0003307", "id": "01129cad6b5d0987"}
{"subject": "GO:0014055", "predicate": "biolink:regulates", "object": "UBERON:0007652", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01233_MESH_D005764_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0014055", "original_object": "UBERON:0007652", "id": "01133c25a051a5be"}
{"subject": "GO:0036098", "predicate": "biolink:affects", "object": "CL:0000016", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0036098", "original_object": "CL:0000016", "id": "0125479b7c6de523"}
{"subject": "UMLS:C0065374", "predicate": "biolink:treats", "object": "MONDO:0005100", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00722", "original_object": "DOID:418", "id": "01262744c6a186e8"}
{"subject": "GO:0006874", "predicate": "biolink:positively_correlated_with", "object": "GO:0001503", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00481_MESH_D015663_1", "DB06401_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006874", "original_object": "GO:0001503", "id": "0128c0e3c3f1ef98"}
{"subject": "PR:000036841", "predicate": "biolink:has_part", "object": "PR:000036831", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:000036841", "original_object": "PR:000036831", "id": "012936374c3e1ef8"}
{"subject": "UBERON:0008877", "predicate": "biolink:subclass_of", "object": "GO:0005604", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0008877", "original_object": "UBERON:0005769", "id": "012d70a919df994c"}
{"object": "NCBIGene:4986", "predicate": "biolink:has_participant", "subject": "GO:0038003", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01183_MESH_D009293_1", "DB01183_MESH_D010146_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P41145", "original_subject": "GO:0038003", "id": "012df66d778eacc9"}
{"object": "NCBIGene:4986", "predicate": "biolink:has_participant", "subject": "GO:0038003", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01183_MESH_D009293_1", "DB01183_MESH_D010146_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P41145", "original_subject": "GO:0038003", "id": "012df66d778eacc9"}
{"subject": "CHEBI:4055", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:16551", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:10235", "original_object": "PUBCHEM.COMPOUND:7427", "id": "0131fcf3f13969e8"}
{"subject": "CHEBI:38007", "predicate": "biolink:subclass_of", "object": "CHEBI:16382", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:38007", "original_object": "CHEBI:24858", "id": "01327088a40baf17"}
{"subject": "MONDO:0005311", "predicate": "biolink:contributes_to", "object": "HP:0001681", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09069_MESH_D000787_1", "DB01076_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002621", "original_object": "MESH:D000787", "id": "01357210fa225939"}
{"subject": "CHEBI:3160", "predicate": "biolink:has_adverse_event", "object": "HP:0001945", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 200.792, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5368", "original_object": "MEDDRA:10037660", "id": "0135ee720a3554d7"}
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{"subject": "CHEBI:3160", "predicate": "biolink:has_adverse_event", "object": "MONDO:0001835", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 408.65, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5368", "original_object": "MEDDRA:10016062", "id": "0545aeb41c10cf42"}
{"subject": "GO:0099544", "predicate": "biolink:coexists_with", "object": "GO:0045202", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0099544", "original_object": "GO:0045202", "id": "05493451ca7e6b28"}
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{"subject": "CHEBI:18022", "predicate": "biolink:subclass_of", "object": "HP:0000118", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:30951", "original_object": "HP:0000118", "id": "0751c8841a82e6c0"}
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{"subject": "CHEBI:18243", "predicate": "biolink:located_in", "object": "UBERON:0001910", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00850_MESH_D012559_1", "DB01224_MESH_D012559_1", "DB08922_MESH_D012559_1", "DB04842_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:18243", "original_object": "UBERON:0001910", "id": "079485c542224c6a"}
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{"subject": "CHEBI:3752", "predicate": "biolink:affects", "object": "CHEBI:81569", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00882_MESH_D007247_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D002996", "original_object": "MESH:D005640", "id": "079586ef03b43d33"}
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{"subject": "CHEBI:18358", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00553_MESH_D016410_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008730", "original_object": "MESH:D004247", "id": "07e88f46cf424b8e"}
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{"subject": "REACT:R-HSA-2162123", "predicate": "biolink:affects", "object": "CHEBI:15627", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00806_MESH_D016491_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "REACT:R-HSA-2162123", "original_object": "MESH:D013928", "id": "08f9ead8731237a0"}
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{"subject": "CHEBI:17154", "predicate": "biolink:affects", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D009536", "original_object": "UBERON:0001866", "id": "091624079fa30dba"}
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{"subject": "GO:0007259", "predicate": "biolink:regulates", "object": "GO:0019221", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08877_MESH_D011087_1", "DB08877_MESH_D009196_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0007259", "original_object": "GO:0019221", "id": "092c7b9ed6c3ca15"}
{"subject": "GO:0006914", "predicate": "biolink:temporally_related_to", "object": "GO:0055085", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006914", "original_object": "GO:0055085", "id": "093a7f1f8e58a438"}
{"subject": "HGNC.FAMILY:1927", "predicate": "biolink:contributes_to", "object": "MONDO:0005412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11739_MESH_D004381_1", "DB00927_MESH_D004381_1", "DB00338_MESH_D004381_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:1927", "original_object": "MESH:D004381", "id": "093f42897564d66f"}
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{"subject": "CHEBI:3655", "predicate": "biolink:regulates", "object": "GO:0016917", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00356_MESH_D009128_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D002753", "original_object": "GO:0016917", "id": "0be0aac866dd02a7"}
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{"subject": "NCBIGene:10019", "predicate": "biolink:acts_upstream_of_or_within_negative_effect", "object": "GO:0038163", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:20404132", "PMID:27430239"], "original_subject": "UniProtKB:Q9UQQ2", "original_object": "GO:0038163", "id": "0c02cbd739221d2e"}
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{"subject": "CHEBI:26865", "predicate": "biolink:has_part", "object": "CHEBI:33353", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:26865", "original_object": "CHEBI:33353", "id": "0f99ce7425f1169b"}
{"subject": "UBERON:0014635", "predicate": "biolink:overlaps", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0014635", "original_object": "NCBITaxon:6072", "id": "0fa006d864ee9229"}
{"subject": "NCBIGene:5153", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:176719", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01244_MESH_D000787_8"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q01064", "original_object": "MESH:D002147", "id": "0fed236440452c76"}
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{"subject": "CHEBI:135443", "predicate": "biolink:treats", "object": "MONDO:0004247", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2226", "original_object": "UMLS:C0030920", "id": "103c0bd9c5042ff7"}
{"subject": "CHEBI:91848", "predicate": "biolink:related_to", "object": "CHEBI:24869", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:91848", "original_object": "CHEBI:24869", "id": "103c80c7026b907f"}
{"subject": "CHEBI:17987", "predicate": "biolink:affects", "object": "NCBITaxon:52283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06770_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D019905", "original_object": "NCBITaxon:52283", "id": "10410ce775d087ec"}
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{"subject": "UBERON:0007475", "predicate": "biolink:composed_primarily_of", "object": "GO:0031012", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0007475", "original_object": "GO:0031012", "id": "108d4450bd3bf66f"}
{"subject": "CHEBI:28502", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005100", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00797", "original_object": "DOID:418", "id": "10ccf6a3c3c319da"}
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{"subject": "CHEBI:3901", "predicate": "biolink:treats", "object": "CHEBI:3901", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4516", "original_object": "UMLS:C0010192", "id": "10db8ea4aaec4dfd"}
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{"subject": "CHEBI:15552", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:5739", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01240_MESH_D003139_1", "DB01240_MESH_D006976_1", "DB01240_MESH_D012220_1", "DB01240_MESH_D065631_1", "DB01240_MESH_D000081029_1", "DB01240_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011464", "original_object": "UniProtKB:P43119", "id": "113022ad95f73b97"}
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{"subject": "MESH:C078049", "predicate": "biolink:regulates", "object": "GO:0009340", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01044_MESH_D018410_1", "DB01044_MESH_D003234_1", "DB01044_MESH_D061387_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C078049", "original_object": "GO:0009340", "id": "116c5cf0a687c32e"}
{"subject": "GO:0060612", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D005230", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060612", "original_object": "MESH:D005230", "id": "1191d5cfce994050"}
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{"subject": "NCBIGene:153", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18357", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00571_MESH_D002312_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08588", "original_object": "MESH:D009638", "id": "11c68ea0afd8b293"}
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{"subject": "CHEBI:92769", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:6530", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4577", "original_object": "UniProtKB:P23975", "id": "1d0f79c771a206ac"}
{"subject": "CHEBI:92769", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:6530", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4577", "original_object": "UniProtKB:P23975", "id": "1d0f79c771a206ac"}
{"subject": "CHEBI:92769", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:6530", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4577", "original_object": "UniProtKB:P23975", "id": "1d0f79c771a206ac"}
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{"subject": "NCBIGene:7276", "predicate": "biolink:enables", "object": "GO:0042802", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05352_MESH_D000686_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P02766", "original_object": "GO:0042802", "id": "22eb054306a1fa14"}
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{"subject": "MONDO:0005469", "predicate": "biolink:occurs_in", "object": "MONDO:0005180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06262_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001278", "original_object": "MESH:D010300", "id": "23e93bee30db3929"}
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{"subject": "GO:1990231", "predicate": "biolink:capable_of", "object": "GO:0060337", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990231", "original_object": "GO:0060337", "id": "3323fb09c45b7040"}
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{"subject": "GO:0030073", "predicate": "biolink:regulates", "object": "MESH:D001786", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01382_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0030073", "original_object": "MESH:D001786", "id": "3344503ee5e5fda5"}
{"subject": "CHEBI:7660", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002180_1", "DB00646_MESH_D002179_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009761", "original_object": "CHEBI:16933", "id": "33b005eeb5322588"}
{"subject": "CHEBI:7660", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002180_1", "DB00646_MESH_D002179_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009761", "original_object": "CHEBI:16933", "id": "33b005eeb5322588"}
{"subject": "GO:0098991", "predicate": "biolink:overlaps", "object": "GO:0035725", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098991", "original_object": "GO:0035725", "id": "33d724e5cebc4635"}
{"subject": "CHEBI:15422", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5661", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05630_MESH_D007896_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000255", "original_object": "NCBITaxon:5661", "id": "343595521f11593f"}
{"subject": "CHEBI:15422", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5661", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05630_MESH_D007896_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000255", "original_object": "NCBITaxon:5661", "id": "343595521f11593f"}
{"subject": "NCBIGene:3641571", "predicate": "biolink:produces", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01263_MESH_D009181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P10613", "original_object": "MESH:D004875", "id": "347144b14a2ee3c0"}
{"subject": "NCBIGene:3641571", "predicate": "biolink:produces", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01263_MESH_D009181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P10613", "original_object": "MESH:D004875", "id": "347144b14a2ee3c0"}
{"subject": "GO:0030520", "predicate": "biolink:treats", "object": "MONDO:0001196", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01708_MESH_D004414_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030520", "original_object": "MESH:D004414", "id": "347cb4a85908ae73"}
{"subject": "NCBIGene:7442", "predicate": "biolink:regulates", "object": "CL:0000197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00405_MESH_D011537_1", "DB01084_MESH_D011537_1", "DB00557_MESH_D011537_1", "DB06691_MESH_D011537_1", "DB09555_MESH_D011537_1", "DB01114_MESH_D011537_1", "DB08799_MESH_D011537_1", "DB00434_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:Q8NER1", "original_object": "CL:0000197", "id": "3480cf06d5209a1f"}
{"subject": "NCBIGene:7442", "predicate": "biolink:regulates", "object": "CL:0000197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00405_MESH_D011537_1", "DB01084_MESH_D011537_1", "DB00557_MESH_D011537_1", "DB06691_MESH_D011537_1", "DB09555_MESH_D011537_1", "DB01114_MESH_D011537_1", "DB08799_MESH_D011537_1", "DB00434_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:Q8NER1", "original_object": "CL:0000197", "id": "3480cf06d5209a1f"}
{"subject": "CHEBI:190303", "predicate": "biolink:subclass_of", "object": "HP:0000118", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:190303", "original_object": "HP:0000118", "id": "357f656bcd7b3aa0"}
{"subject": "CHEBI:30746", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:15428", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03793_MESH_D022124_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D019817", "original_object": "MESH:D005998", "id": "3600953f3053d096"}
{"subject": "CHEBI:30746", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:15428", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03793_MESH_D022124_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D019817", "original_object": "MESH:D005998", "id": "3600953f3053d096"}
{"subject": "CL:0000819", "predicate": "biolink:related_to", "object": "NCBITaxon:1", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000819", "original_object": "NCBITaxon:1", "id": "3628f184a1955172"}
{"subject": "NCBIGene:3352", "predicate": "biolink:affects", "object": "UBERON:0001645", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00918_MESH_D008881_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:P28221", "original_object": "UBERON:0001645", "id": "3636020c0cb854d2"}
{"subject": "NCBIGene:3352", "predicate": "biolink:affects", "object": "UBERON:0001645", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00918_MESH_D008881_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:P28221", "original_object": "UBERON:0001645", "id": "3636020c0cb854d2"}
{"object": "GO:0004714", "predicate": "biolink:has_participant", "subject": "REACT:R-HSA-74713", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09564_MESH_D003920_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0004714", "original_subject": "REACT:R-HSA-74713", "id": "364964042f9efc16"}
{"subject": "NCBIGene:1813", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01618_MESH_D012559_1", "DB11757_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P14416", "original_object": "MESH:D004298", "id": "36773f33044c0945"}
{"subject": "NCBIGene:1813", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01618_MESH_D012559_1", "DB11757_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P14416", "original_object": "MESH:D004298", "id": "36773f33044c0945"}
{"subject": "REACT:R-HSA-381377", "predicate": "biolink:affects", "object": "UMLS:C0334227", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "bone metastasis", "causal_mechanism_qualifier": "activation", "disease_context_qualifier": "MONDO:0008315", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:33731701"], "primary_knowledge_source": "infores:ccidb", "original_subject": "REACT:R-HSA-381377", "original_object": "UMLS:C0334227", "id": "36cee8c793e04373"}
{"subject": "GO:0051381", "predicate": "biolink:regulates", "object": "GO:0023041", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08799_MESH_D012912_1", "DB00434_MESH_D012912_2", "DB00637_MESH_D012912_1", "DB09488_MESH_D012912_1", "DB00950_MESH_D012912_1", "DB00434_MESH_D012912_1", "DB00341_MESH_D012912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0051381", "original_object": "GO:0023041", "id": "370a9560840c3e46"}
{"subject": "GO:0000380", "predicate": "biolink:produces", "object": "UniProtKB:B4DP61", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13161_MESH_D009134_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000380", "original_object": "UniProtKB:B4DP61", "id": "372c34254686877f"}
{"subject": "NCBIGene:5578", "predicate": "biolink:contributes_to", "object": "GO:0051823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D001714_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P17252", "original_object": "GO:0051823", "id": "379b1deff1dea346"}
{"subject": "NCBIGene:5578", "predicate": "biolink:contributes_to", "object": "GO:0051823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D001714_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P17252", "original_object": "GO:0051823", "id": "379b1deff1dea346"}
{"subject": "CHEBI:34911", "predicate": "biolink:disrupts", "object": "UniProtKB:Q2VKV7", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04930_MESH_D012532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D026023", "original_object": "UniProtKB:Q2VKV7", "id": "37de16a5fbd945c2"}
{"subject": "CHEBI:34911", "predicate": "biolink:disrupts", "object": "UniProtKB:Q2VKV7", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04930_MESH_D012532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D026023", "original_object": "UniProtKB:Q2VKV7", "id": "37de16a5fbd945c2"}
{"subject": "CHEBI:18085", "predicate": "biolink:occurs_in", "object": "GO:0005764", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01279_MESH_D009087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006025", "original_object": "GO:0005764", "id": "37f9dbe3db7e97df"}
{"subject": "NCBIGene:2", "predicate": "biolink:affects", "object": "MESH:D028321", "primary_knowledge_source": "infores:ctd", "description": "decreases uptake of", "NCBITaxon": "9606", "publications": ["PMID:27262837"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:2", "original_object": "MESH:D028321", "object_aspect_qualifier": "uptake", "object_direction_qualifier": "decreased", "qualified_predicate": "biolink:causes", "id": "3810a3cf0d059df6"}
{"subject": "NCBIGene:2", "predicate": "biolink:affects", "object": "MESH:D028321", "primary_knowledge_source": "infores:ctd", "description": "decreases uptake of", "NCBITaxon": "9606", "publications": ["PMID:27262837"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:2", "original_object": "MESH:D028321", "object_aspect_qualifier": "uptake", "object_direction_qualifier": "decreased", "qualified_predicate": "biolink:causes", "id": "3810a3cf0d059df6"}
{"subject": "UBERON:0000176", "predicate": "biolink:causes", "object": "HP:0025095", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00972_MESH_D065631_1", "DB00972_MESH_D006255_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000176", "original_object": "HP:0025095", "id": "3829bddbe7189f2c"}
{"subject": "CHEBI:5790", "predicate": "biolink:regulates", "object": "UBERON:0001896", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00327_MESH_D003371_1", "DB00327_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D004091", "original_object": "UBERON:0001896", "id": "384da5d22b919c1e"}
{"subject": "CHEBI:5790", "predicate": "biolink:regulates", "object": "UBERON:0001896", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00327_MESH_D003371_1", "DB00327_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D004091", "original_object": "UBERON:0001896", "id": "384da5d22b919c1e"}
{"subject": "CHEBI:21553", "predicate": "biolink:correlated_with", "object": "NCBIGene:5310", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:18215696", "PMID:21389975"], "original_subject": "HMDB:HMDB0006029", "original_object": "OMIM:601313", "id": "386d13ad619c7b8c"}
{"subject": "CHEBI:21553", "predicate": "biolink:correlated_with", "object": "NCBIGene:5310", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:18215696", "PMID:21389975"], "original_subject": "HMDB:HMDB0006029", "original_object": "OMIM:601313", "id": "386d13ad619c7b8c"}
{"subject": "UNII:1693AM5SBN", "predicate": "biolink:decreases_response_to", "object": "NCBIGene:3481", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "NCBITaxon": "10116", "publications": ["PMID:23419388"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C028972", "original_object": "NCBIGENE:3481", "id": "38b52b376a5bbe97"}
{"subject": "UNII:1693AM5SBN", "predicate": "biolink:decreases_response_to", "object": "NCBIGene:3481", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "NCBITaxon": "10116", "publications": ["PMID:23419388"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C028972", "original_object": "NCBIGENE:3481", "id": "38b52b376a5bbe97"}
{"subject": "UBERON:0001090", "predicate": "biolink:has_part", "object": "CHEBI:16336", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001090", "original_object": "CHEBI:16336", "id": "38e8a27f8a41daca"}
{"subject": "UBERON:0001090", "predicate": "biolink:has_part", "object": "CHEBI:16336", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001090", "original_object": "CHEBI:16336", "id": "38e8a27f8a41daca"}
{"subject": "UBERON:4000115", "predicate": "biolink:has_part", "object": "CHEBI:52255", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:4000115", "original_object": "CHEBI:52255", "id": "39041c9531dc3539"}
{"subject": "HP:0032263", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005068", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00722_MESH_D009203_1", "DB00335_MESH_D009203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0032263", "original_object": "MESH:D009203", "id": "395a8de4cfc6cb11"}
{"subject": "CHEBI:77035", "predicate": "biolink:affects", "object": "UBERON:0016553", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00874_MESH_D012220_1", "DB00874_MESH_D065631_1", "DB00874_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D005100", "original_object": "UBERON:0016553", "id": "397f3bcf3f5f25b0"}
{"subject": "GO:0071159", "predicate": "biolink:affects", "object": "NCBIGene:7412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00806_MESH_D016491_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0071159", "original_object": "UniProtKB:P19320", "id": "398b1d8bad6dcb11"}
{"subject": "GO:0071159", "predicate": "biolink:affects", "object": "NCBIGene:7412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00806_MESH_D016491_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0071159", "original_object": "UniProtKB:P19320", "id": "398b1d8bad6dcb11"}
{"subject": "CHEBI:18243", "predicate": "biolink:negatively_correlated_with", "object": "PUBCHEM.COMPOUND:16132350", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00937_MESH_D009765_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004298", "original_object": "MESH:D009478", "id": "39d0c79adbea3aaa"}
{"subject": "CHEBI:18243", "predicate": "biolink:negatively_correlated_with", "object": "PUBCHEM.COMPOUND:16132350", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00937_MESH_D009765_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004298", "original_object": "MESH:D009478", "id": "39d0c79adbea3aaa"}
{"subject": "UBERON:0005304", "predicate": "biolink:positively_correlated_with", "object": "GO:0050892", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08900_MESH_D012778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0005304", "original_object": "GO:0050892", "id": "39e4882e3a728f0d"}
{"subject": "UBERON:0003092", "predicate": "biolink:has_part", "object": "PR:000027222", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003092", "original_object": "PR:000027222", "id": "3a9afe0923787700"}
{"subject": "CHEBI:39867", "predicate": "biolink:causes", "object": "UMLS:C1868980", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00313", "original_object": "UMLS:C1868980", "id": "3aa8f278ebf94d1f"}
{"subject": "CHEBI:39867", "predicate": "biolink:causes", "object": "UMLS:C1868980", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00313", "original_object": "UMLS:C1868980", "id": "3aa8f278ebf94d1f"}
{"subject": "GO:0004714", "predicate": "biolink:regulates", "object": "NCBIGene:207", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01307_MESH_D003920_1", "DB01306_MESH_D003920_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004714", "original_object": "UniProtKB:P31749", "id": "3abc6999ed870075"}
{"subject": "UMLS:C0023775", "predicate": "biolink:disrupts", "object": "GO:0006811", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002180_1", "DB00646_MESH_D002179_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0023775", "original_object": "GO:0006811", "id": "3b00e97c60ab3516"}
{"subject": "UBERON:0001707", "predicate": "biolink:correlated_with", "object": "MONDO:0004979", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01410_MESH_D001249_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001707", "original_object": "MESH:D001249", "id": "3bef813c72b029b1"}
{"subject": "CHEBI:63625", "predicate": "biolink:has_active_ingredient", "object": "PUBCHEM.COMPOUND:5481180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00300_MESH_D019694_1", "DB00300_MESH_D015658_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000068698", "original_object": "MESH:C583447", "id": "3bf441fee6113aef"}
{"subject": "UBERON:0001295", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0021251", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00603_MESH_D016889_1", "DB00351_MESH_D016889_1", "DB00396_MESH_D016889_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001295", "original_object": "MESH:D016889", "id": "3c0621d84b0d1e75"}
{"subject": "CHEBI:28786", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D012135", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:11874814"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010269", "original_object": "MESH:D012135", "id": "3c58a3a24dd18514"}
{"subject": "GO:0071159", "predicate": "biolink:regulates", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04837_MESH_D065631_1", "DB04837_MESH_D012220_1", "DB00434_MESH_D065631_1", "DB01114_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0071159", "original_object": "GO:0006954", "id": "3ce038565bebe8d0"}
{"subject": "UMLS:C2607955", "predicate": "biolink:causes", "object": "GO:0008219", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C2607955", "original_object": "GO:0008219", "id": "3ce8eada544cf2cf"}
{"subject": "NCBIGene:154", "predicate": "biolink:regulates", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01214_MESH_D009798_1", "DB01214_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P07550", "original_object": "UBERON:0001796", "id": "3cfa526f4faae556"}
{"subject": "NCBIGene:154", "predicate": "biolink:regulates", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01214_MESH_D009798_1", "DB01214_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P07550", "original_object": "UBERON:0001796", "id": "3cfa526f4faae556"}
{"subject": "CHEBI:30769", "predicate": "biolink:disrupts", "object": "UBERON:0000912", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09154_MESH_D003139_1", "DB09154_MESH_D012220_1", "DB09154_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000077559", "original_object": "UBERON:0000912", "id": "3d2642465f38bbc2"}
{"subject": "CHEBI:30769", "predicate": "biolink:disrupts", "object": "UBERON:0000912", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09154_MESH_D003139_1", "DB09154_MESH_D012220_1", "DB09154_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000077559", "original_object": "UBERON:0000912", "id": "3d2642465f38bbc2"}
{"subject": "CL:0005020", "predicate": "biolink:coexists_with", "object": "UBERON:0004536", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0005020", "original_object": "UBERON:0004536", "id": "3d8bc16ef81a38e6"}
{"object": "MONDO:0001380", "predicate": "biolink:has_part", "subject": "UBERON:0001255", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "NCIT:C12332", "original_subject": "NCIT:C12414", "id": "3ec89a125a905585"}
{"subject": "UBERON:0018687", "predicate": "biolink:located_in", "object": "GO:0005604", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0018687", "original_object": "GO:0005604", "id": "3ef8a2c3a7cb502f"}
{"subject": "CHEBI:6437", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0020039", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1563", "original_object": "UMLS:C0020039", "id": "3f0ea5ddc74d43b2"}
{"subject": "CHEBI:6437", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0020039", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1563", "original_object": "UMLS:C0020039", "id": "3f0ea5ddc74d43b2"}
{"subject": "NCBIGene:2554", "predicate": "biolink:capable_of", "object": "GO:0022851", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09166_MESH_D001008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P14867", "original_object": "GO:0022851", "id": "3f26ffd677425913"}
{"subject": "HGNC.FAMILY:404", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR11716", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D009450_1", "DB01234_MESH_D007627_1", "DB01234_MESH_D016403_1", "DB01234_MESH_D000799_1", "DB01234_MESH_D065631_1", "DB01234_MESH_D012214_1", "DB01234_MESH_D012393_1", "DB01234_MESH_D003320_1", "DB01234_MESH_D003877_1", "DB01234_MESH_D008180_1", "DB01234_MESH_D014235_1", "DB00240_MESH_D003876_1", "DB01234_MESH_D001929_1", "DB01234_MESH_D013717_2", "DB01234_MESH_D014391_1", "DB01234_MESH_D010392_1", "DB01234_MESH_D008224_1", "DB01234_MESH_D000744_1", "DB01234_MESH_D009140_1", "DB01234_MESH_D013167_1", "DB01234_MESH_D009101_1", "DB00240_MESH_D011538_1", "DB01234_MESH_D013716_1", "DB01234_MESH_D011565_1", "DB01234_MESH_D016410_1", "DB01234_MESH_D003876_1", "DB01234_MESH_D014605_1", "DB01234_MESH_D016460_1", "DB00240_MESH_D005076_1", "DB01234_MESH_D012713_1", "DB01234_MESH_D003424_1", "DB01234_MESH_D005128_1", "DB01234_MESH_D010032_1", "DB01234_MESH_D003874_1", "DB01234_MESH_D003233_1", "DB01234_MESH_D003873_1", "DB01234_MESH_D011538_1", "DB01234_MESH_D009404_1", "DB01234_MESH_D007634_1", "DB01234_MESH_D012871_1", "DB01234_MESH_D012628_1", "DB00240_MESH_D012628_1", "DB01234_MESH_D011657_1", "DB01234_MESH_D015535_1", "DB01234_MESH_D002062_1", "DB01234_MESH_D001607_1", "DB00240_MESH_D016410_1", "DB01234_MESH_D006689_1", "DB01234_MESH_D007500_1", "DB00240_MESH_D008179_1", "DB01234_MESH_D002051_1", "DB01234_MESH_D009103_1", "DB01234_MESH_D015863_1", "DB00240_MESH_D003877_1", "DB01234_MESH_D005076_1", "DB01234_MESH_D013966_1", "DB01234_MESH_C562390_1", "DB01234_MESH_D009182_1", "DB01234_MESH_D012507_1", "DB01234_MESH_D008179_1", "DB01234_MESH_D008228_1", "DB01234_MESH_D001249_1", "DB01234_MESH_D029503_1", "DB01234_MESH_D007819_1", "DB01234_MESH_D001172_1", "DB01234_MESH_D009450_1", "DB01234_MESH_D004892_1", "DB01234_MESH_D015210_1", "DB01234_MESH_D015212_1", "DB00240_MESH_D016460_1", "DB01234_MESH_D014606_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "HGNC.FAMILY:404", "original_object": "PANTHER.FAMILY:PTHR11716", "id": "3f7d2b831f066366"}
{"subject": "MONDO:0002012", "predicate": "biolink:causes", "object": "MONDO:0002320", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00115_MESH_D001361_1", "DB00115_MESH_D014806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002912", "original_object": "HP:0000707", "id": "3f8c7b6494a7777e"}
{"subject": "GO:0071420", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01075_MESH_D006255_1", "DB00748_MESH_D006255_1", "DB01075_MESH_D012223_1", "DB01075_MESH_D003233_1", "DB00748_MESH_D012223_1", "DB00748_MESH_D003139_1", "DB00748_MESH_D014581_1", "DB00748_MESH_D003233_2", "DB00748_MESH_D065631_1", "DB00748_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071420", "original_object": "MESH:D006632", "id": "3f95335ec2b299c8"}
{"subject": "GO:0023041", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002009", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00344_MESH_D003865_1", "DB06148_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0023041", "original_object": "MESH:D003865", "id": "401b383d60e320e2"}
{"subject": "GO:0019233", "predicate": "biolink:occurs_in", "object": "HP:0100607", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06691_MESH_D004412_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019233", "original_object": "MESH:D004412", "id": "402ab47bdd015c36"}
{"subject": "GO:0014046", "predicate": "biolink:located_in", "object": "UBERON:0001910", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06144_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0014046", "original_object": "UBERON:0001910", "id": "403f9b64a112aee5"}
{"subject": "CHEBI:16113", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005098", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00175_MESH_D020521_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002784", "original_object": "MESH:D020521", "id": "40b74c06707dafac"}
{"subject": "PR:000050296", "predicate": "biolink:develops_from", "object": "CL:0000826", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:000050296", "original_object": "CL:0000826", "id": "40ec7b24609b20f5"}
{"subject": "UBERON:0004128", "predicate": "biolink:causes", "object": "UBERON:0004880", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004128", "original_object": "UBERON:0004880", "id": "40fa859b59bea4bb"}
{"object": "GO:0031929", "predicate": "biolink:causes", "subject": "GO:0038201", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0031929", "original_subject": "GO:0038201", "id": "411b288fa3531912"}
{"subject": "CHEBI:46345", "predicate": "biolink:has_active_ingredient", "object": "PUBCHEM.COMPOUND:10255482", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09256_MESH_D013274_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005472", "original_object": "MESH:C025635", "id": "419d6d030d37152f"}
{"subject": "CHEBI:16113", "predicate": "biolink:located_in", "object": "UBERON:0002110", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01586_MESH_D002769_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002784", "original_object": "UBERON:0002110", "id": "41a41a29544abc84"}
{"subject": "MONDO:0021042", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "UNII:C4V974V932", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6304244", "PMC:8278705", "PMC:6304244", "PMC:6304244", "PMC:8278705"], "tmkp_confidence_score": 0.6542058325883658, "sentences": "In vivo SPIO@DSPE-PEG/DOX/ICG NP treatment resulted in a remarkable antitumor effect against glioma as compared with all other groups examined.|NA|To conclude, we report in the present study that ICG/PTX@RGE-EV can function as a potential drug delivery system of ICG/PTX for treatment of glioma, as evidenced by its prolonged residence period in blood circulation, and increased accumulation in tumor, thereby promoting anti-tumor action and reducing toxicity (Fig.?8).|NA|These results suggest that the SPIO@DSPE-PEG/DOX/ICG NPs can not only function as a nanoprobe for MR and fluorescence bimodal imaging, but also as a vehicle to deliver chemotherapeutic drugs to the tumor site, to achieve the theranostic treatment of glioma.|NA|To evaluate the safety, toxicity, and side effects of SPIO@DSPE-PEG/DOX/ICG NPs within glioma-bearing rats during the treatment, H&E-stained sections from the heart, liver, spleen, lung, kidney, and muscle were examined (Figure S3).|NA|The results of our study first elucidated that the inhibitory impact of ICG/PTX@RGE-EV on glioma development via apoptosis promotion, which suggested that ICG/PTX@RGE-EV might eventually be employed clinically for the treatment of glioma.|NA", "tmkp_ids": ["tmkp:367807965a370eabc32394f2c49f101f00f2290a4462d07d233d45e57481bd47", "tmkp:a08ea6fd10f89987c1fc2202d2b91f5567b79d5b7420121740116322e905cebf", "tmkp:6d141174d57a39002d1519ef17f408852aeb7667cf8bb121947f1143762508ad", "tmkp:abbd396a87c661d1f63739faf637cfde9e9627d641d19196e5a662ea04d28014", "tmkp:fe258a3fd612c261ad52efc78173d03c54f9debde90f20d8791dbd9542740d2a"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "MONDO:0021042", "original_object": "DRUGBANK:DB16024", "id": "41a50dfea018a5ef"}
{"subject": "HP:0000616", "predicate": "biolink:negatively_correlated_with", "object": "HP:0007663", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01057_MESH_D000080362_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000616", "original_object": "HP:0007663", "id": "41ef3f05090dc872"}
{"subject": "MONDO:0003947", "predicate": "biolink:disrupts", "object": "GO:0023035", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0003947", "original_object": "GO:0023035", "id": "41f45c64670a1dd1"}
{"subject": "MESH:C006632", "predicate": "biolink:affects", "object": "CHEBI:26523", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01169_MESH_D015479_1", "DB01169_MESH_D015473_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:C006632", "original_object": "CHEBI:26523", "id": "4206301e0aafd7f1"}
{"subject": "UBERON:0000410", "predicate": "biolink:correlated_with", "object": "GO:0070254", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06767_MESH_D003371_1", "DB06767_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000410", "original_object": "GO:0070254", "id": "4229e5572117c78f"}
{"subject": "NCBIGene:153", "predicate": "biolink:affects", "object": "HGNC.FAMILY:53", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00187_MESH_D001281_1", "DB00187_MESH_D013617_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:P08588", "original_object": "HGNC.FAMILY:53", "id": "431070bf3d27dfc9"}
{"subject": "NCBIGene:153", "predicate": "biolink:affects", "object": "HGNC.FAMILY:53", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00187_MESH_D001281_1", "DB00187_MESH_D013617_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:P08588", "original_object": "HGNC.FAMILY:53", "id": "431070bf3d27dfc9"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0000403", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00443_MESH_D012536_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "UBERON:0000403", "id": "431e2c7d345de586"}
{"subject": "MESH:D014028", "predicate": "biolink:increases_response_to", "object": "NCBIGene:2950", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "NCBITaxon": "9606", "publications": ["PMID:23643483"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014028", "original_object": "NCBIGENE:2950", "id": "4321bf4259261e53"}
{"subject": "MESH:D014028", "predicate": "biolink:increases_response_to", "object": "NCBIGene:2950", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "NCBITaxon": "9606", "publications": ["PMID:23643483"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014028", "original_object": "NCBIGENE:2950", "id": "4321bf4259261e53"}
{"subject": "CHEBI:18361", "predicate": "biolink:regulates", "object": "CHEBI:52255", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05768_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:18361", "original_object": "CHEBI:52255", "id": "43615366090123fa"}
{"subject": "CHEBI:82405", "predicate": "biolink:regulates", "object": "NCBITaxon:1747", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09096_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D001585", "original_object": "NCBITaxon:1747", "id": "43db68142d83d2d8"}
{"subject": "CHEBI:82405", "predicate": "biolink:regulates", "object": "NCBITaxon:1747", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09096_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D001585", "original_object": "NCBITaxon:1747", "id": "43db68142d83d2d8"}
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{"subject": "CHEBI:66903", "predicate": "biolink:contraindicated_in", "object": "UNII:UFH8805FKA", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4227", "original_object": "UMLS:C0813171", "id": "5a943afd55603051"}
{"subject": "CHEBI:66903", "predicate": "biolink:contraindicated_in", "object": "UNII:UFH8805FKA", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4227", "original_object": "UMLS:C0813171", "id": "5a943afd55603051"}
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{"subject": "GO:0019369", "predicate": "biolink:regulates", "object": "GO:0005886", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00711_MESH_D009855_1", "DB00711_MESH_D008118_1", "DB00711_MESH_D004604_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019369", "original_object": "GO:0005886", "id": "5bb177cf25ab5a2a"}
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{"subject": "NCBIGene:1633", "predicate": "biolink:related_to", "object": "GO:0044818", "primary_knowledge_source": "infores:signor", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:27879648"], "description": ["Deoxycytidine kinase (dCK) is a key enzyme in deoxyribonucleoside salvage and the anti-tumor activity for many nucleoside analogs. dCK is activated in response to ionizing radiation (IR)-induced DNA damage and it is phosphorylated on Serine 74 by the Ataxia-Telangiectasia Mutated (ATM) kinase in order to activate the cell cycle G2/M checkpoint."], "original_subject": "UniProtKB:P27707", "original_object": "GO:0044818", "id": "5efd071b668c1fb5"}
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{"subject": "CHEBI:82720", "predicate": "biolink:preventative_for_condition", "object": "UMLS:C1320716", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4830", "original_object": "UMLS:C1320716", "id": "5fdd908609a0288e"}
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{"subject": "CHEBI:27436", "predicate": "biolink:precedes", "object": "CHEBI:34179", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06710_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008777", "original_object": "CHEBI:34179", "id": "6a1fd3a5d614a9c1"}
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{"subject": "NCBIGene:1128", "predicate": "biolink:regulates", "object": "UBERON:0001044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00986_MESH_D012798_1", "DB00424_MESH_D012798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P11229", "original_object": "UBERON:0001044", "id": "6e51e399b13982d1"}
{"subject": "GO:0098990", "predicate": "biolink:has_input", "object": "CHEBI:36915", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098990", "original_object": "CHEBI:36915", "id": "6e6ee117709899f2"}
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{"subject": "NCBIGene:2798", "predicate": "biolink:target_for", "object": "UMLS:C0029967", "drugmechdb_path_id": ["DB06785_MESH_D010062_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "primary_knowledge_source": "infores:drugmechdb", "original_subject": "UniProtKB:P30968", "original_object": "UMLS:C0029967", "id": "e59cfa23fd319d45"}
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{"subject": "NCBIGene:3350", "predicate": "biolink:correlated_with", "object": "CHEBI:28790", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12833_MESH_D002012_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08908", "original_object": "MESH:D012701", "id": "e9c9a8c2783e3209"}
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{"subject": "UNII:Z633861EIM", "predicate": "biolink:similar_to", "object": "NCBIGene:249", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05768_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB05768", "original_object": "UniProtKB:P05186", "id": "e9db7d277a669089"}
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