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                        "UniProtKB:P13236",
                        "UniProtKB:P15260",
                        "UniProtKB:P35225",
                        "UniProtKB:P01584",
                        "UniProtKB:O14763",
                        "UniProtKB:P00995",
                        "UniProtKB:P50591",
                        "UniProtKB:P08476",
                        "UniProtKB:P19875",
                        "UniProtKB:P08887",
                        "UniProtKB:P08648",
                        "UniProtKB:P00533",
                        "UniProtKB:P05362",
                        "UniProtKB:O00182",
                        "UniProtKB:P02778",
                        "UniProtKB:Q13873",
                        "UniProtKB:P80188",
                        "UniProtKB:P16234",
                        "UniProtKB:P35443",
                        "UniProtKB:Q16581",
                        "UniProtKB:Q15109",
                        "UniProtKB:P18627",
                        "UniProtKB:P01133",
                        "UniProtKB:Q9Y6Q6",
                        "NCBIGene:562822",
                        "UniProtKB:P41597",
                        "UniProtKB:P61073",
                        "UniProtKB:P32241",
                        "UniProtKB:P56706",
                        "UniProtKB:O43508",
                        "UniProtKB:P32248",
                        "UniProtKB:P26992",
                        "UniProtKB:P49765",
                        "UniProtKB:Q00182",
                        "UniProtKB:Q14627",
                        "UniProtKB:P04216",
                        "UniProtKB:Q16552",
                        "UniProtKB:P36897",
                        "UniProtKB:P37173",
                        "UniProtKB:P36222",
                        "UniProtKB:O60462",
                        "UniProtKB:O96014",
                        "NCBIGene:445706",
                        "UniProtKB:P16070",
                        "UniProtKB:P17948",
                        "UniProtKB:Q96MS0",
                        "UniProtKB:P21860",
                        "UniProtKB:P51681",
                        "UniProtKB:Q6UXV0",
                        "UniProtKB:P18084",
                        "UniProtKB:P35968",
                        "UniProtKB:O00421",
                        "UniProtKB:P30530",
                        "NCBIGene:101450768",
                        "UniProtKB:P78504",
                        "UNII:1B56C968OA",
                        "UniProtKB:P01375",
                        "UniProtKB:P51671",
                        "UniProtKB:P21802",
                        "UniProtKB:P05106",
                        "UniProtKB:P05019",
                        "UniProtKB:P80162",
                        "UniProtKB:Q9H1J7",
                        "UniProtKB:O75084",
                        "UniProtKB:Q16620",
                        "UniProtKB:Q13308",
                        "UniProtKB:P16109",
                        "UniProtKB:Q5DX21",
                        "UniProtKB:P46531",
                        "UniProtKB:P78556",
                        "UniProtKB:O75051",
                        "UniProtKB:P07949",
                        "UniProtKB:P06756",
                        "UniProtKB:P05556",
                        "UniProtKB:Q99435",
                        "UniProtKB:O95760",
                        "UniProtKB:Q9H7M9",
                        "UniProtKB:P22301",
                        "UniProtKB:P14778",
                        "UniProtKB:P08637",
                        "UniProtKB:Q15063",
                        "UniProtKB:P09038",
                        "UniProtKB:Q02297",
                        "UniProtKB:P15692",
                        "UniProtKB:P49682",
                        "UniProtKB:P24001",
                        "CHEBI:30031",
                        "UniProtKB:P13500",
                        "UniProtKB:P36894",
                        "UniProtKB:P28300",
                        "UniProtKB:P21453",
                        "UniProtKB:P49747",
                        "UniProtKB:P08620",
                        "UniProtKB:P07333",
                        "UniProtKB:Q15465",
                        "UniProtKB:P01344",
                        "UniProtKB:P04626",
                        "UniProtKB:Q14314",
                        "UniProtKB:Q01629",
                        "UniProtKB:P51677",
                        "UniProtKB:P36896",
                        "UniProtKB:P39905",
                        "UniProtKB:P10451",
                        "UniProtKB:P19876",
                        "UniProtKB:Q15116",
                        "UniProtKB:P51685",
                        "UniProtKB:P09341",
                        "UniProtKB:P42830",
                        "UniProtKB:P32246",
                        "UniProtKB:P06702",
                        "UniProtKB:P10145",
                        "UniProtKB:Q9BXN1",
                        "UniProtKB:P01889",
                        "UniProtKB:O14786",
                        "UniProtKB:P80098",
                        "UniProtKB:O43927",
                        "UniProtKB:Q14393",
                        "UniProtKB:P08581",
                        "UniProtKB:P10124",
                        "UniProtKB:Q9ULV1",
                        "UniProtKB:P26441",
                        "UniProtKB:P42702",
                        "UniProtKB:P49767",
                        "UniProtKB:Q96F46",
                        "UniProtKB:P35916",
                        "UniProtKB:Q14508",
                        "UniProtKB:Q8N423",
                        "UniProtKB:P05231",
                        "UniProtKB:O95750",
                        "UniProtKB:P17096",
                        "UniProtKB:O95150",
                        "UniProtKB:P09544",
                        "UniProtKB:Q13635",
                        "UniProtKB:O75581",
                        "UniProtKB:O95388",
                        "UniProtKB:P11362",
                        "UniProtKB:P78324",
                        "UniProtKB:Q9NRA1",
                        "UniProtKB:P40189",
                        "UniProtKB:P32302",
                        "UniProtKB:P09619",
                        "UniProtKB:Q9UBD9",
                        "UniProtKB:Q9NPH3",
                        "UniProtKB:Q9GZP0",
                        "PUBCHEM.COMPOUND:95065620",
                        "UniProtKB:Q08722",
                        "UniProtKB:P14210",
                        "UniProtKB:Q9NP84",
                        "NCBIGene:378570",
                        "UniProtKB:P78552",
                        "UniProtKB:P01282",
                        "UniProtKB:P13612",
                        "UniProtKB:Q92520",
                        "UniProtKB:O14625",
                        "UniProtKB:Q08830",
                        "UniProtKB:P23229",
                        "UniProtKB:P01031",
                        "UniProtKB:P56199",
                        "UniProtKB:Q02763",
                        "UniProtKB:Q07954",
                        "UniProtKB:P01583",
                        "UniProtKB:Q9H4X1",
                        "UniProtKB:Q99988",
                        "UniProtKB:Q86Z14",
                        "UniProtKB:Q9ULZ1",
                        "UniProtKB:O14788",
                        "UniProtKB:O95980",
                        "UniProtKB:P17301",
                        "UniProtKB:P49763",
                        "UniProtKB:P01127",
                        "UniProtKB:P23560",
                        "UniProtKB:P21462",
                        "CHEBI:15551",
                        "UniProtKB:P20366",
                        "UniProtKB:P25103",
                        "UniProtKB:Q01638",
                        "UniProtKB:P22362",
                        "UniProtKB:Q96LC7",
                        "UniProtKB:P20333",
                        "UniProtKB:P35414",
                        "UniProtKB:P13725",
                        "UniProtKB:Q4G0W2",
                        "UniProtKB:P24821",
                        "UniProtKB:Q93038",
                        "UniProtKB:Q9BXB1",
                        "UniProtKB:P12644",
                        "UniProtKB:O75364",
                        "UniProtKB:P15018",
                        "UniProtKB:P06744",
                        "UniProtKB:O76093",
                        "UniProtKB:Q99985",
                        "UniProtKB:P61812",
                        "UniProtKB:P01135",
                        "UniProtKB:P48061",
                        "UniProtKB:P16671",
                        "UniProtKB:P25063",
                        "UniProtKB:P04629",
                        "UniProtKB:P53634",
                        "UniProtKB:P41159",
                        "UniProtKB:O00755",
                        "UniProtKB:P05121",
                        "UniProtKB:P19438",
                        "UniProtKB:O95817",
                        "UniProtKB:O00220",
                        "UniProtKB:P01024",
                        "UniProtKB:Q07065",
                        "UniProtKB:Q99527",
                        "UniProtKB:P18065",
                        "UniProtKB:P25025",
                        "UniProtKB:Q03167",
                        "UniProtKB:Q92956",
                        "UniProtKB:P01137",
                        "UniProtKB:Q99731",
                        "UniProtKB:P13501",
                        "UniProtKB:Q9NZQ7",
                        "UniProtKB:Q9GZM7",
                        "NCBIGene:100149452",
                        "UniProtKB:P21730",
                        "UniProtKB:Q13651",
                        "UniProtKB:P05107",
                        "UniProtKB:P19320",
                        "UniProtKB:P31785",
                        "UniProtKB:P43235",
                        "UniProtKB:P12643",
                        "UniProtKB:P04083",
                        "UniProtKB:P05112",
                        "UniProtKB:P16144",
                        "UniProtKB:P25024",
                        "UniProtKB:O00585",
                        "UniProtKB:P08069",
                        "UniProtKB:P24394",
                        "UniProtKB:P22607",
                        "UniProtKB:Q7Z6A9",
                        "UniProtKB:Q8WUG5",
                        "UniProtKB:P41221",
                        "UniProtKB:O94907",
                        "UniProtKB:Q14332",
                        "UniProtKB:P24158",
                        "UniProtKB:Q96PE1",
                        "UniProtKB:Q2MKA7",
                        "UniProtKB:P01138",
                        "UniProtKB:P01374",
                        "UniProtKB:Q15303"
                    ]
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                {
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                    "applicable_values": [
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                        "UMLS:C1512505",
                        "CL:0002138",
                        "CL:0000136",
                        "CL:0000094",
                        "CL:0002139",
                        "UMLS:C3891660",
                        "CL:0000763",
                        "UMLS:C0242633",
                        "UMLS:C4086501",
                        "CL:0000632",
                        "CL:1000488",
                        "CL:0000084",
                        "UMLS:C0024264",
                        "CL:0000127",
                        "UMLS:C4277548",
                        "CL:0000669",
                        "CL:0002573",
                        "CL:0000920",
                        "CL:0000746",
                        "CL:0000312",
                        "CL:0000148",
                        "CL:0000186",
                        "CL:0000623",
                        "UMLS:C0334227",
                        "UMLS:C2350466",
                        "UMLS:C1513095",
                        "CL:0000899",
                        "CL:0002410",
                        "CL:0000077",
                        "UMLS:C3827754",
                        "CL:0000129",
                        "UMLS:C0596890",
                        "UMLS:C0027950",
                        "UMLS:C1267822",
                        "CL:0000055",
                        "CL:0002204",
                        "UMLS:C0018894",
                        "UMLS:C0026473",
                        "CL:0000115",
                        "CL:0000134",
                        "CL:0000057",
                        "UMLS:C1512478",
                        "UMLS:C1301034",
                        "UMLS:C1636199",
                        "CL:0000499",
                        "CL:0000451",
                        "CL:0000786",
                        "CL:0000236",
                        "CL:0000540",
                        "UMLS:C0027625",
                        "UMLS:C0015350",
                        "CL:0000889",
                        "CL:0000235",
                        "UMLS:C1956422",
                        "UMLS:C0027836"
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                },
                {
                    "qualifier_type_id": "disease_context_qualifier",
                    "applicable_values": [
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                        "MONDO:0009693",
                        "MONDO:0007256",
                        "MONDO:0004958",
                        "MONDO:0010150",
                        "MONDO:0006082",
                        "MONDO:0850353",
                        "MONDO:0003210",
                        "MONDO:0004992",
                        "MONDO:0005061",
                        "MONDO:0018177",
                        "MONDO:0008170",
                        "MONDO:0005494",
                        "MONDO:0006804",
                        "MONDO:1040026",
                        "MONDO:0005105",
                        "MONDO:0021042",
                        "MONDO:0005411",
                        "UMLS:C0346976",
                        "UMLS:C0334227",
                        "MONDO:0005233",
                        "UMLS:C0153676",
                        "MONDO:0005192",
                        "MONDO:0007254",
                        "MONDO:0004274",
                        "MONDO:0005096",
                        "MONDO:0004967",
                        "MONDO:0002974",
                        "MONDO:0004990",
                        "MONDO:0007959",
                        "MONDO:0019087",
                        "MONDO:0005184",
                        "UMLS:C5551176",
                        "MONDO:0005580",
                        "MONDO:0011719",
                        "MONDO:0006047",
                        "MONDO:0015459",
                        "UMLS:C4721779",
                        "MONDO:0008903",
                        "MONDO:0005575",
                        "MONDO:0008315",
                        "MONDO:0002529",
                        "MONDO:0001056",
                        "MONDO:0004948",
                        "MONDO:0009807",
                        "MONDO:0018874",
                        "MONDO:0005059"
                    ]
                },
                {
                    "qualifier_type_id": "object_form_or_variant_qualifier",
                    "applicable_values": [
                        "UMLS:C3896693",
                        "UniProtKB:O43490 (+)",
                        "NCBIGene:929 (+) NCBIGene:729230 (+)",
                        "UMLS:C0278488",
                        "NCBIGene:7099 (+)",
                        "normoxic",
                        "UniProtKB:Q29040 (+)",
                        "NCBIGene:4233 unamplified"
                    ]
                },
                {
                    "qualifier_type_id": "subject_specialization_qualifier",
                    "applicable_values": [
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                        "UBERON:0001013",
                        "UBERON:0007798",
                        "UBERON:0002012",
                        "UBERON:0000992",
                        "UBERON:0000044",
                        "UBERON:0000945",
                        " ",
                        "UMLS:C4277702",
                        "UBERON:0003688",
                        "UBERON:0001295",
                        "UBERON:0000955"
                    ]
                },
                {
                    "qualifier_type_id": "object_specialization_qualifier",
                    "applicable_values": [
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                        "UBERON:0001013",
                        "UBERON:0000992",
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                        " ",
                        "UMLS:C4277702",
                        "UBERON:0001295",
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            ]
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        {
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            "predicate": "biolink:affects",
            "object": "biolink:Gene",
            "attributes": [
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                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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                {
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                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
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                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
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                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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            "qualifiers": [
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                    "applicable_values": [
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                {
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                    "applicable_values": [
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                        "activation"
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                },
                {
                    "qualifier_type_id": "subject_context_qualifier",
                    "applicable_values": [
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                        "UniProtKB:P32248",
                        "UniProtKB:P08887",
                        "UniProtKB:P05231"
                    ]
                },
                {
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                    "applicable_values": [
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                        "CL:0000115",
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                }
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        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:Gene",
            "attributes": [
                {
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                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:publications",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
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                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "disease_context_qualifier",
                    "applicable_values": [
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                        "MONDO:0009693",
                        "MONDO:0007254",
                        "MONDO:0005575",
                        "MONDO:0010150"
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                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:affects",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:publications",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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                    "applicable_values": [
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                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
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                },
                {
                    "qualifier_type_id": "causal_mechanism_qualifier",
                    "applicable_values": [
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                {
                    "qualifier_type_id": "subject_context_qualifier",
                    "applicable_values": [
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                        "UniProtKB:P41597",
                        "UniProtKB:P18510",
                        "UniProtKB:P14778"
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                },
                {
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                    "applicable_values": [
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        {
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            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
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        {
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            "predicate": "biolink:affects",
            "object": "biolink:MolecularActivity",
            "attributes": [
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                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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                {
                    "attribute_type_id": "biolink:publications",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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            "qualifiers": [
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                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
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                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
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                {
                    "qualifier_type_id": "subject_context_qualifier",
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                        "UniProtKB:P36897",
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                {
                    "qualifier_type_id": "anatomical_context_qualifier",
                    "applicable_values": [
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        {
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            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
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                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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                {
                    "attribute_type_id": "biolink:publications",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
                    "constraint_name": null
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                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
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                    "constraint_use": false,
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