{ "source_type": "primary", "edges": [ { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Disease", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:167638", "object_id": "UMLS:C0271149" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Disease", "predicate": "biolink:has_adverse_event", "subject_id": "CHEBI:43755", "object_id": "MONDO:0005609" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Disease", "predicate": "biolink:applied_to_treat", "subject_id": "UNII:EH6D7113I8", "object_id": "UMLS:C1720498" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Disease", "predicate": "biolink:treats", "subject_id": "CHEBI:6919", "object_id": "EFO:1001421" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Disease", "predicate": "biolink:diagnoses", "subject_id": "PUBCHEM.COMPOUND:134612761", "object_id": "UMLS:C1720505" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:76016", "object_id": "CHEBI:38623" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:31784", "object_id": "CHEBI:33674" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:3398", "object_id": "HP:0200119" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:has_adverse_event", "subject_id": "CHEBI:32095", "object_id": "UMLS:C5400280" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:preventative_for_condition", "subject_id": "CHEBI:82720", "object_id": "UMLS:C1320716" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:applied_to_treat", "subject_id": "CHEBI:42797", "object_id": "HP:0000989" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:treats", "subject_id": "CHEBI:27732", "object_id": "HP:0001257" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Protein", "predicate": "biolink:directly_physically_interacts_with", "subject_id": "CHEBI:72317", "object_id": "UniProtKB:Q13163" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Protein", "predicate": "biolink:related_to", "subject_id": "CHEBI:3089", "object_id": "UniProtKB:Q9X6V3" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Protein", "predicate": "biolink:affects", "subject_id": "CHEBI:190509", "object_id": "UniProtKB:A2RP81", "qualifiers": [ { "qualifier_type_id": "biolink:object_aspect_qualifier", "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:object_direction_qualifier", "qualifier_value": "decreased" }, { "qualifier_type_id": "biolink:qualified_predicate", "qualifier_value": "biolink:causes" } ] }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Protein", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:81567", "object_id": "PR:000000001" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:SmallMolecule", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:32016", "object_id": "CHEBI:5138" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:SmallMolecule", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:81064", "object_id": "CHEBI:17334" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:SmallMolecule", "predicate": "biolink:treats", "subject_id": "UNII:DD5RBA1NKF", "object_id": "UNII:DD5RBA1NKF" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:102265", "object_id": "UMLS:C0032981" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:MolecularMixture", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:4514", "object_id": "CHEBI:32952" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ChemicalMixture", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:135752", "object_id": "CHEBI:60004" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:applied_to_treat", "subject_id": "CHEBI:6704", "object_id": "NCBITaxon:6211" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:28748", "object_id": "UMLS:C1633725" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:16977", "object_id": "UMLS:C0022650" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Behavior", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:6437", "object_id": "UMLS:C0020039" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:63616", "object_id": "MESH:D022341" }, { "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Device", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:50580", "object_id": "UMLS:C0030163" }, { "subject_category": "biolink:Disease", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:subclass_of", "subject_id": "MONDO:0001244", "object_id": "HP:0032245" }, { "subject_category": "biolink:Disease", "object_category": "biolink:Disease", "predicate": "biolink:subclass_of", "subject_id": "MONDO:0016975", "object_id": "MONDO:0005070" }, { "subject_category": "biolink:Disease", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:subclass_of", "subject_id": "MONDO:0021156", "object_id": "UBERON:0001062" }, { "subject_category": "biolink:Disease", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:subclass_of", "subject_id": "MONDO:0004934", "object_id": "UBERON:0002384" }, { "subject_category": "biolink:Protein", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:subclass_of", "subject_id": "UniProtKB:P47936", "object_id": "CHEBI:23367" }, { "subject_category": "biolink:Protein", "object_category": "biolink:Protein", "predicate": "biolink:subclass_of", "subject_id": "UniProtKB:P09455", "object_id": "PR:000000001" }, { "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:Disease", "predicate": "biolink:subclass_of", "subject_id": "NCIT:C56911", "object_id": "EFO:0009658" }, { "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:subclass_of", "subject_id": "HP:0000967", "object_id": "NCIT:C26791" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Disease", "predicate": "biolink:applied_to_treat", "subject_id": "CHEBI:2922", "object_id": "MONDO:0011849" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Disease", "predicate": "biolink:treats", "subject_id": "CHEBI:64735", "object_id": "MONDO:0024612" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Disease", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:31607", "object_id": "MONDO:0002869" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Disease", "predicate": "biolink:has_adverse_event", "subject_id": "CHEBI:8389", "object_id": "MONDO:0013600" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:144421", "object_id": "CHEBI:5975" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:31355", "object_id": "UMLS:C1623040" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:63043", "object_id": "HP:0025354" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:has_adverse_event", "subject_id": "CHEBI:32139", "object_id": "UMLS:C0877219" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:applied_to_treat", "subject_id": "CHEBI:17833", "object_id": "EFO:0003952" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:treats", "subject_id": "CHEBI:3314", "object_id": "HP:0003472" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Protein", "predicate": "biolink:directly_physically_interacts_with", "subject_id": "CHEBI:2930", "object_id": "UniProtKB:O95264" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Protein", "predicate": "biolink:related_to", "subject_id": "CHEBI:27899", "object_id": "UniProtKB:O15440" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Protein", "predicate": "biolink:affects", "subject_id": "CHEBI:6078", "object_id": "UniProtKB:P36544", "qualifiers": [ { "qualifier_type_id": "biolink:object_aspect_qualifier", "qualifier_value": "activity" } ] }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:SmallMolecule", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:86368", "object_id": "CHEBI:17996" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:contraindicated_in", "subject_id": "UNII:2URQ2N32W3", "object_id": "UMLS:C0022650" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:ChemicalMixture", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:141517", "object_id": "CHEBI:60027" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:113455", "object_id": "UMLS:C1633725" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:MolecularMixture", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:37585", "object_id": "CHEBI:34683" }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:8346", "object_id": "UMLS:C0032981" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Disease", "predicate": "biolink:applied_to_treat", "subject_id": "CHEBI:50845", "object_id": "MONDO:0005825" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Disease", "predicate": "biolink:treats", "subject_id": "UNII:G6UF363ECX", "object_id": "MONDO:0850353" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Disease", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:60773", "object_id": "UMLS:C0267094" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Disease", "predicate": "biolink:has_adverse_event", "subject_id": "UNII:953A26OA1Y", "object_id": "UMLS:C0276447" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:contraindicated_in", "subject_id": "UNII:K2J09EMJ52", "object_id": "UMLS:C0032981" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:applied_to_treat", "subject_id": "CHEBI:17486", "object_id": "HP:0000011" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:contraindicated_in", "subject_id": "CHEBI:5537", "object_id": "HP:0001657" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:has_adverse_event", "subject_id": "UNII:7D0YB67S97", "object_id": "UMLS:C4284007" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:treats", "subject_id": "CHEBI:145791", "object_id": "EFO:0006865" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:28115", "object_id": "CHEBI:75769" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Protein", "predicate": "biolink:directly_physically_interacts_with", "subject_id": "CHEBI:85164", "object_id": "UniProtKB:Q07002" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Protein", "predicate": "biolink:related_to", "subject_id": "CHEBI:145701", "object_id": "UniProtKB:P20309" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Protein", "predicate": "biolink:affects", "subject_id": "CHEBI:9437", "object_id": "UniProtKB:A0A024AXB9", "qualifiers": [ { "qualifier_type_id": "biolink:object_aspect_qualifier", "qualifier_value": "activity" }, { "qualifier_type_id": "biolink:object_direction_qualifier", "qualifier_value": "increased" }, { "qualifier_type_id": "biolink:qualified_predicate", "qualifier_value": "biolink:causes" } ] }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:15824", "object_id": "CHEBI:28757" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:16528", "object_id": "CHEBI:17833" }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:ChemicalMixture", "predicate": "biolink:subclass_of", "subject_id": "CHEBI:32293", "object_id": "CHEBI:60004" }, { "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:subclass_of", "subject_id": "NCBITaxon:6211", "object_id": "NCBITaxon:33213" }, { "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:subclass_of", "subject_id": "NCBITaxon:6211", "object_id": "UBERON:0000465" }, { "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:Disease", "predicate": "biolink:subclass_of", "subject_id": "UBERON:0012281", "object_id": "MONDO:0002260" } ] }