{"subject": "CHEBI:10304", "predicate": "biolink:affects", "object": "UniProtKB:P08913", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00968_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "CHEBI:141146", "original_object": "UniProtKB:P08913"}
{"subject": "CHEBI:15343", "predicate": "biolink:positively_correlated_with", "object": "HP:0001033", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00822_MESH_D000437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:15343", "original_object": "HP:0001033"}
{"subject": "CHEBI:15355", "predicate": "biolink:negatively_correlated_with", "object": "HP:0100543", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00674_MESH_D000544_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:15355", "original_object": "HP:0100543"}
{"subject": "CHEBI:15355", "predicate": "biolink:regulates", "object": "UBERON:0000381", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00424_MESH_D053159_1", "DB00458_MESH_D053206_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:15355", "original_object": "UBERON:0000381"}
{"subject": "CHEBI:15356", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:16856", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06151_MESH_D000686_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:15356", "original_object": "CHEBI:16856"}
{"subject": "CHEBI:15356", "predicate": "biolink:affects", "object": "UBERON:0000912", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06151_MESH_D001987_2", "DB06151_MESH_D001991_2", "DB06151_MESH_D003550_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "CHEBI:15356", "original_object": "UBERON:0000912"}
{"subject": "CHEBI:15356", "predicate": "biolink:subclass_of", "object": "UMLS:C0026698", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06151_MESH_D001987_2", "DB06151_MESH_D001991_2", "DB06151_MESH_D003550_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:15356", "original_object": "UMLS:C0026698"}
{"object": "CHEBI:15422", "predicate": "biolink:has_participant", "subject": "GO:0060047", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09270_MESH_D006333_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CHEBI:15422", "original_subject": "GO:0060047"}
{"subject": "CHEBI:15430", "predicate": "biolink:disrupts", "object": "NCBITaxon:5833", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01218_MESH_D016778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:15430", "original_object": "NCBITaxon:5833"}
{"subject": "CHEBI:15551", "predicate": "biolink:regulates", "object": "HP:0001945", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01397_MESH_D005334_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:15551", "original_object": "MESH:D005334"}
{"subject": "CHEBI:15551", "predicate": "biolink:treats", "object": "MONDO:0001126", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05197_MESH_D013276_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:15551", "original_object": "MESH:D013276"}
{"subject": "CHEBI:15765", "predicate": "biolink:positively_correlated_with", "object": "GO:0001963", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00494_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:15765", "original_object": "GO:0001963"}
{"subject": "CHEBI:15889", "predicate": "biolink:in_taxon", "object": "NCBITaxon:5658", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09031_MESH_D007897_1", "DB09031_MESH_D016773_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:15889", "original_object": "NCBITaxon:5658"}
{"subject": "CHEBI:15940", "predicate": "biolink:affects", "object": "CHEBI:17154", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08949_MESH_D010383_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "CHEBI:15940", "original_object": "CHEBI:17154"}
{"subject": "CHEBI:15940", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0019975", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00627_MESH_D001361_1", "DB02701_MESH_D010383_1", "DB04145_MESH_D010383_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:15940", "original_object": "HP:0100497"}
{"subject": "CHEBI:16113", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005311", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00227_MESH_D001161_1", "DB00641_MESH_D020521_1", "DB01076_MESH_D000787_1", "DB01076_MESH_D000788_1", "DB01076_MESH_D001161_1", "DB01076_MESH_D020521_1", "DB01095_MESH_D001161_1", "DB01098_MESH_D015228_1", "DB09069_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16113", "original_object": "HP:0002621"}
{"subject": "CHEBI:16134", "predicate": "biolink:correlated_with", "object": "HP:0001987", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00581_MESH_D006501_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16134", "original_object": "HP:0001987"}
{"subject": "CHEBI:16136", "predicate": "biolink:subclass_of", "object": "CHEBI:36047", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00257_MESH_D000152_3", "DB00257_MESH_D005892_1", "DB00257_MESH_D013281_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16136", "original_object": "MESH:D000900"}
{"subject": "CHEBI:16136", "predicate": "biolink:subclass_of", "object": "CHEBI:86327", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00257_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16136", "original_object": "MESH:D000935"}
{"subject": "CHEBI:16247", "predicate": "biolink:in_taxon", "object": "NCBITaxon:5658", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09031_MESH_D007897_1", "DB09031_MESH_D016773_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16247", "original_object": "NCBITaxon:5658"}
{"subject": "CHEBI:16284", "predicate": "biolink:negatively_correlated_with", "object": "GO:0006260", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00552_MESH_D007943_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16284", "original_object": "GO:0006260"}
{"subject": "CHEBI:16335", "predicate": "biolink:affects", "object": "HGNC.FAMILY:211", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00563_MESH_D011565_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "CHEBI:16335", "original_object": "HGNC.FAMILY:211"}
{"subject": "CHEBI:16356", "predicate": "biolink:positively_correlated_with", "object": "GO:0007263", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00820_MESH_D006976_1", "DB00820_MESH_D007172_1", "DB00820_MESH_D011470_1", "DB11792_MESH_D007172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16356", "original_object": "GO:0007263"}
{"object": "CHEBI:16356", "predicate": "biolink:has_participant", "subject": "GO:0038060", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08931_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CHEBI:16356", "original_subject": "GO:0038060"}
{"subject": "CHEBI:16356", "predicate": "biolink:regulates", "object": "GO:0044557", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00203_MESH_D000081029_1", "DB00203_MESH_D007172_2", "DB00325_MESH_D006973_1", "DB00862_MESH_D007172_1", "DB06237_MESH_D007172_1", "DB06267_MESH_D007172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:16356", "original_object": "GO:0044557"}
{"subject": "CHEBI:16412", "predicate": "biolink:located_in", "object": "GO:0009274", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00781_MESH_D003234_1", "DB00781_MESH_D007634_1", "DB00781_MESH_D010032_1", "DB00781_MESH_D014552_1", "DB00781_MESH_D014605_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16412", "original_object": "GO:0009274"}
{"subject": "CHEBI:16412", "predicate": "biolink:regulates", "object": "REACT:R-HSA-166016", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:16412", "original_object": "REACT:R-HSA-166016"}
{"subject": "CHEBI:16480", "predicate": "biolink:regulates", "object": "GO:0004383", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00325_MESH_D006973_1", "DB09282_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:16480", "original_object": "GO:0004383"}
{"subject": "CHEBI:16480", "predicate": "biolink:regulates", "object": "UniProtKB:P16066", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00727_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:16480", "original_object": "UniProtKB:P16066"}
{"subject": "CHEBI:16521", "predicate": "biolink:negatively_correlated_with", "object": "GO:0009277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06636_MESH_D001228_1", "DB06636_MESH_D009091_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16521", "original_object": "GO:0009277"}
{"subject": "CHEBI:16865", "predicate": "biolink:correlated_with", "object": "GO:0060077", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09118_MESH_D004831_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16865", "original_object": "GO:0060077"}
{"subject": "CHEBI:16933", "predicate": "biolink:contributes_to", "object": "GO:0009277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06636_MESH_D001228_1", "DB06636_MESH_D009091_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16933", "original_object": "GO:0009277"}
{"subject": "CHEBI:17256", "predicate": "biolink:disrupts", "object": "CL:0000084", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00061_MESH_C531816_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17256", "original_object": "CL:0000084"}
{"subject": "CHEBI:172731", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00242_MESH_D007943_1", "DB00242_MESH_D020529_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:172731", "original_object": "MESH:D004247"}
{"subject": "CHEBI:17376", "predicate": "biolink:causes", "object": "MONDO:0008171", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06823_MESH_D003555_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17376", "original_object": "HP:0000787"}
{"subject": "CHEBI:17376", "predicate": "biolink:causes", "object": "HP:0033067", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06823_MESH_D003555_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17376", "original_object": "HP:0033067"}
{"subject": "CHEBI:17489", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00195_MESH_D005902_1", "DB00195_MESH_D009798_1", "DB00484_MESH_D005902_2", "DB00484_MESH_D009798_2", "DB00521_MESH_D005902_1", "DB00521_MESH_D009798_1", "DB09351_MESH_D005902_1", "DB09351_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17489", "original_object": "UBERON:0001796"}
{"subject": "CHEBI:176783", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:22652", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01698_MESH_D001206_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:176783", "original_object": "MESH:D001205"}
{"subject": "CHEBI:17716", "predicate": "biolink:has_metabolite", "object": "CHEBI:28061", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13761_MESH_D007787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17716", "original_object": "CHEBI:28061"}
{"subject": "CHEBI:18059", "predicate": "biolink:located_in", "object": "GO:0016020", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03808_MESH_D015823_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:18059", "original_object": "GO:0016020"}
{"subject": "CHEBI:18059", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0021187", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00227_MESH_D006949_1", "DB00973_MESH_D006949_1", "DB01599_MESH_D006949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:18059", "original_object": "MESH:D006949"}
{"subject": "CHEBI:18085", "predicate": "biolink:positively_correlated_with", "object": "HP:0000969", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00279_MESH_D009230_1", "DB00451_MESH_D009230_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:18085", "original_object": "HP:0000969"}
{"object": "CHEBI:18111", "predicate": "biolink:has_participant", "subject": "GO:0006412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00994_MESH_D007634_1", "DB00994_MESH_D010032_1", "DB00994_MESH_D014552_1", "DB00994_MESH_D014605_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CHEBI:18111", "original_subject": "GO:0006412"}
{"subject": "CHEBI:18243", "predicate": "biolink:correlated_with", "object": "GO:0032225", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00477_MESH_D011618_1", "DB00477_MESH_D012559_1", "DB00477_MESH_D017118_1", "DB00477_MESH_D019958_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:18243", "original_object": "GO:0032225"}
{"subject": "CHEBI:18243", "predicate": "biolink:located_in", "object": "UBERON:0001910", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00850_MESH_D012559_1", "DB01224_MESH_D012559_1", "DB04842_MESH_D012559_1", "DB08922_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:18243", "original_object": "UBERON:0001910"}
{"subject": "CHEBI:18243", "predicate": "biolink:located_in", "object": "UBERON:0009834", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01224_MESH_D012559_1", "DB04842_MESH_D012559_1", "DB08922_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:18243", "original_object": "UBERON:0009834"}
{"subject": "CHEBI:18361", "predicate": "biolink:regulates", "object": "CHEBI:52255", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05768_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:18361", "original_object": "CHEBI:52255"}
{"subject": "CHEBI:22587", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0005109", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09065_MESH_D015658_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:22587", "original_object": "MESH:D015658"}
{"subject": "CHEBI:24838", "predicate": "biolink:correlated_with", "object": "HP:0100529", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09561_MESH_D017674_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:24838", "original_object": "HP:0100529"}
{"subject": "CHEBI:25029", "predicate": "biolink:positively_correlated_with", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:25029", "original_object": "GO:0006954"}
{"subject": "CHEBI:25029", "predicate": "biolink:correlated_with", "object": "GO:0043303", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00972_MESH_D003233_1", "DB00972_MESH_D006255_1", "DB00972_MESH_D012223_1", "DB00972_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:25029", "original_object": "GO:0043303"}
{"subject": "CHEBI:26523", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11820_MESH_D014355_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:26523", "original_object": "CHEBI:16991"}
{"subject": "CHEBI:28300", "predicate": "biolink:produces", "object": "CHEBI:17884", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08909_MESH_D056806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:28300", "original_object": "CHEBI:17884"}
{"subject": "CHEBI:28648", "predicate": "biolink:located_in", "object": "CL:0001063", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09077_MESH_D009447_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:28648", "original_object": "CL:0001063"}
{"subject": "CHEBI:29034", "predicate": "biolink:located_in", "object": "CHEBI:35143", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08826_MESH_D017086_1", "DB08826_MESH_D019190_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:29034", "original_object": "CHEBI:35143"}
{"subject": "CHEBI:30411", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0001700", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00200_MESH_D000752_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:30411", "original_object": "HP:0001889"}
{"subject": "CHEBI:30411", "predicate": "biolink:negatively_correlated_with", "object": "HP:0020060", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00200_MESH_D000752_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:30411", "original_object": "HP:0020060"}
{"subject": "CHEBI:35143", "predicate": "biolink:correlated_with", "object": "MONDO:0019402", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08826_MESH_D017086_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:35143", "original_object": "MESH:D017086"}
{"subject": "CHEBI:35475", "predicate": "biolink:regulates", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08984_MESH_D010003_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:35475", "original_object": "GO:0006954"}
{"subject": "CHEBI:43394", "predicate": "biolink:affects", "object": "CHEBI:18085", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00090_MESH_D008059_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "CHEBI:43394", "original_object": "MESH:D006025"}
{"subject": "CHEBI:50919", "predicate": "biolink:negatively_correlated_with", "object": "HP:0002018", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00372_MESH_D009325_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:50919", "original_object": "MESH:D009325"}
{"subject": "CHEBI:63726", "predicate": "biolink:treats", "object": "MONDO:0005314", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06685_MESH_D020529_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:63726", "original_object": "MESH:D020529"}
{"object": "CHEBI:75316", "predicate": "biolink:derives_from", "subject": "MESH:D010648", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08909_MESH_D056806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CHEBI:75316", "original_subject": "MESH:D010648"}
{"subject": "CHEBI:77035", "predicate": "biolink:affects", "object": "GO:0120197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06715_MESH_D003139_1", "DB06715_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "CHEBI:77035", "original_object": "GO:0120197"}
{"subject": "CHEBI:82717", "predicate": "biolink:affects", "object": "GO:0005840", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09042_MESH_D017192_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "CHEBI:82717", "original_object": "GO:0005840"}
{"subject": "CL:0000037", "predicate": "biolink:treats", "object": "MONDO:0009693", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06809_MESH_D009101_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000037", "original_object": "MESH:D009101"}
{"subject": "CL:0000062", "predicate": "biolink:regulates", "object": "GO:0001503", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00017_MESH_D010001_1", "DB00017_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CL:0000062", "original_object": "GO:0001503"}
{"subject": "CL:0000084", "predicate": "biolink:positively_correlated_with", "object": "GO:0002456", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00061_MESH_C531816_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000084", "original_object": "GO:0002456"}
{"object": "CL:0000084", "predicate": "biolink:has_participant", "subject": "GO:0006955", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00859_MESH_D001172_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0000084", "original_subject": "GO:0006955"}
{"subject": "CL:0000084", "predicate": "biolink:causes", "object": "MONDO:0020283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11693_MESH_D014605_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000084", "original_object": "MESH:D014605"}
{"subject": "CL:0000084", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005314", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01204_MESH_D020529_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000084", "original_object": "MESH:D020529"}
{"subject": "CL:0000092", "predicate": "biolink:capable_of", "object": "GO:0045453", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00169_MESH_D010024_1", "DB00169_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000092", "original_object": "GO:0045453"}
{"subject": "CL:0000092", "predicate": "biolink:contributes_to", "object": "GO:0045453", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00783_MESH_D015663_1", "DB00977_MESH_D015663_1", "DB06202_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000092", "original_object": "GO:0045453"}
{"subject": "CL:0000101", "predicate": "biolink:positively_correlated_with", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00265_MESH_D011537_1", "DB00265_MESH_D012532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000101", "original_object": "MESH:D011537"}
{"object": "CL:0000169", "predicate": "biolink:expressed_in", "subject": "UniProtKB:P01308", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01067_MESH_D006943_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0000169", "original_subject": "UniProtKB:P01308"}
{"subject": "CL:0000197", "predicate": "biolink:contributes_to", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00281_MESH_D011537_1", "DB00281_MESH_D011538_1", "DB00281_MESH_D012532_1", "DB00405_MESH_D011537_1", "DB00434_MESH_D011537_1", "DB00557_MESH_D011537_1", "DB01084_MESH_D011537_1", "DB01114_MESH_D011537_1", "DB06691_MESH_D011537_1", "DB08799_MESH_D011537_1", "DB09555_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000197", "original_object": "HP:0000989"}
{"subject": "CL:0000197", "predicate": "biolink:contributes_to", "object": "MONDO:0001780", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00281_MESH_D061686_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000197", "original_object": "MESH:D061686"}
{"subject": "CL:0000198", "predicate": "biolink:regulates", "object": "HP:0012531", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06774_MESH_D001416_1", "DB06774_MESH_D009437_1", "DB06774_MESH_D051474_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CL:0000198", "original_object": "MESH:D010146"}
{"object": "CL:0000232", "predicate": "biolink:located_in", "subject": "GO:0019954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12975_MESH_D016778_2", "DB12975_MESH_D016780_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0000232", "original_subject": "GO:0019954"}
{"subject": "CL:0000232", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002280", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00016_MESH_D000740_1", "DB00158_MESH_D018798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000232", "original_object": "HP:0001903"}
{"object": "CL:0000236", "predicate": "biolink:located_in", "subject": "MONDO:0018906", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00997_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0000236", "original_subject": "MESH:D008224"}
{"subject": "CL:0000317", "predicate": "biolink:affects", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00655_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "CL:0000317", "original_object": "MESH:D012629"}
{"subject": "CL:0000540", "predicate": "biolink:located_in", "object": "UBERON:0000004", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00719_MESH_D012912_1", "DB01114_MESH_D012912_1", "DB01176_MESH_D012912_1", "DB06691_MESH_D012912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000540", "original_object": "UBERON:0000004"}
{"subject": "CL:0000542", "predicate": "biolink:causes", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00563_MESH_D001171_1", "DB00563_MESH_D001172_1", "DB00563_MESH_D011565_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000542", "original_object": "GO:0006954"}
{"object": "CL:0000740", "predicate": "biolink:disrupts", "subject": "MONDO:0005338", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00668_MESH_D005902_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0000740", "original_subject": "MESH:D005902"}
{"object": "CL:0000763", "predicate": "biolink:affects", "subject": "MONDO:0018874", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00056_MESH_D015470_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0000763", "original_subject": "MESH:D015470"}
{"subject": "CL:0001063", "predicate": "biolink:enables", "object": "GO:0008219", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08870_MESH_D006689_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0001063", "original_object": "GO:0008219"}
{"subject": "CL:0001063", "predicate": "biolink:manifestation_of", "object": "MONDO:0018906", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0001063", "original_object": "MESH:D008224"}
{"subject": "CL:0001063", "predicate": "biolink:correlated_with", "object": "MONDO:0005447", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00773_MESH_D013736_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0001063", "original_object": "MESH:D013736"}
{"object": "CL:0001064", "predicate": "biolink:has_participant", "subject": "MONDO:0005075", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09078_MESH_D000077273_1", "DB09078_MESH_D000077273_2", "DB09078_MESH_D000077273_3", "DB09078_MESH_D000077273_4", "DB09078_MESH_D000077273_5"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0001064", "original_subject": "MESH:D000077273"}
{"subject": "CL:0011005", "predicate": "biolink:negatively_correlated_with", "object": "HP:0020219", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01595_MESH_D004831_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0011005", "original_object": "HP:0020219"}
{"subject": "UMLS:C0085272", "predicate": "biolink:affects", "object": "UniProtKB:P30968", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00007_MESH_D004715_1", "DB00007_MESH_D011629_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "DRUGBANK:DB00007", "original_object": "UniProtKB:P30968"}
{"subject": "UMLS:C0111046", "predicate": "biolink:regulates", "object": "GO:0044241", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00085_MESH_D010188_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "DRUGBANK:DB00085", "original_object": "GO:0044241"}
{"subject": "UMLS:C1302054", "predicate": "biolink:chemically_similar_to", "object": "UniProtKB:P35475", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00090_MESH_D008059_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB00090", "original_object": "UniProtKB:P35475"}
{"subject": "CHEBI:17439", "predicate": "biolink:regulates", "object": "UniProtKB:P22033", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00115_MESH_D001361_1", "DB00115_MESH_D014806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "DRUGBANK:DB00115", "original_object": "UniProtKB:P22033"}
{"subject": "CHEBI:17026", "predicate": "biolink:treats", "object": "HP:0031217", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00396_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB00396", "original_object": "MESH:D019584"}
{"subject": "CHEBI:9763", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR11390", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00685_MESH_D004716_1", "DB00685_MESH_D011018_1", "DB00685_MESH_D011019_1", "DB00685_MESH_D011023_1", "DB00685_MESH_D014552_1", "DB00685_MESH_D059413_1", "DB09335_MESH_D011018_1", "DB09335_MESH_D011019_1", "DB09335_MESH_D011023_2", "DB09335_MESH_D014552_1", "DB09335_MESH_D059413_1", "DB09335_MESH_D061387_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "DRUGBANK:DB00685", "original_object": "PANTHER.FAMILY:PTHR11390"}
{"subject": "CHEBI:3642", "predicate": "biolink:causes", "object": "GO:0090075", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00856_MESH_D009128_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB00856", "original_object": "GO:0090075"}
{"subject": "CHEBI:17334", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR22935", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09320_MESH_C536773_1", "DB09320_MESH_C536774_1", "DB09320_MESH_D000881_1", "DB09320_MESH_D004165_1", "DB09320_MESH_D004697_1", "DB09320_MESH_D004886_1", "DB09320_MESH_D004887_1", "DB09320_MESH_D009494_1", "DB09320_MESH_D010612_1", "DB09320_MESH_D010874_1", "DB09320_MESH_D011018_1", "DB09320_MESH_D011906_1", "DB09320_MESH_D012541_1", "DB09320_MESH_D013203_1", "DB09320_MESH_D013290_1", "DB09320_MESH_D013587_1", "DB09320_MESH_D013590_1", "DB09320_MESH_D013592_1", "DB09320_MESH_D014211_1", "DB09320_MESH_D015001_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "DRUGBANK:DB01053", "original_object": "PANTHER.FAMILY:PTHR22935"}
{"subject": "CHEBI:45863", "predicate": "biolink:contraindicated_in", "object": "MONDO:0005338", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01229_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB01229", "original_object": "MESH:D005902"}
{"subject": "UNII:4MG6O8991R", "predicate": "biolink:affects", "object": "UniProtKB:Q9A1X4", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01256_MESH_D007169_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "DRUGBANK:DB01256", "original_object": "UniProtKB:Q9A1X4"}
{"subject": "UNII:T432289GYZ", "predicate": "biolink:affects", "object": "HGNC.FAMILY:1258", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01266_MESH_D003218_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "DRUGBANK:DB01266", "original_object": "HGNC.FAMILY:1258"}
{"subject": "UNII:5W8JGG2651", "predicate": "biolink:chemically_similar_to", "object": "UniProtKB:P22304", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01271_MESH_D016532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB01271", "original_object": "UniProtKB:P22304"}
{"subject": "UNII:Z633861EIM", "predicate": "biolink:similar_to", "object": "UniProtKB:P05186", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05768_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB05768", "original_object": "UniProtKB:P05186"}
{"object": "CHEBI:68642", "predicate": "biolink:derives_from", "subject": "MESH:C000600172", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05812_MESH_D011471_5", "DB05812_MESH_D011471_6"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "DRUGBANK:DB05812", "original_subject": "MESH:C000600172"}
{"subject": "UMLS:C2919267", "predicate": "biolink:affects", "object": "CHEBI:36500", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06720_MESH_D005776_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "DRUGBANK:DB06720", "original_object": "MESH:D005963"}
{"object": "UNII:67M901L9NQ", "predicate": "biolink:has_part", "subject": "MESH:D058427", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06768_MESH_D003876_1", "DB06768_MESH_D003877_1", "DB06768_MESH_D005076_1", "DB06768_MESH_D011537_1", "DB06768_MESH_D011538_1", "DB06768_MESH_D012628_1", "DB06768_MESH_D016460_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "DRUGBANK:DB06768", "original_subject": "MESH:D058427"}
{"subject": "UMLS:C0281581", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:28648", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09077_MESH_D009447_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB09077", "original_object": "CHEBI:28648"}
{"subject": "CHEBI:53258", "predicate": "biolink:regulates", "object": "MESH:D005744", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09154_MESH_D004415_1", "DB09154_MESH_D005764_1", "DB09154_MESH_D006356_1", "DB09154_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "DRUGBANK:DB09154", "original_object": "MESH:D005744"}
{"subject": "UNII:F85N2YHE4E", "predicate": "biolink:affects", "object": "GO:0006635", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09568_MESH_D015228_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "DRUGBANK:DB09568", "original_object": "GO:0006635"}
{"subject": "UNII:F85N2YHE4E", "predicate": "biolink:affects", "object": "UniProtKB:O75907", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09568_MESH_D015228_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "DRUGBANK:DB09568", "original_object": "UniProtKB:O75907"}
{"subject": "UMLS:C0083183", "predicate": "biolink:affects", "object": "CHEBI:17716", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13761_MESH_D007787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "degradation", "original_subject": "DRUGBANK:DB13761", "original_object": "CHEBI:17716"}
{"subject": "GO:0000028", "predicate": "biolink:positively_correlated_with", "object": "GO:0043043", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00976_MESH_D011018_1", "DB00976_MESH_D011019_1", "DB00976_MESH_D013290_1", "DB00976_MESH_D061387_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000028", "original_object": "GO:0043043"}
{"subject": "GO:0000048", "predicate": "biolink:positively_correlated_with", "object": "GO:0006412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01190_MESH_D000152_1", "DB01190_MESH_D011015_1", "DB01190_MESH_D011018_1", "DB01190_MESH_D011023_1", "DB01190_MESH_D013203_1", "DB01190_MESH_D013290_1", "DB01190_MESH_D016585_1", "DB01190_MESH_D016724_1", "DB01190_MESH_D059413_1", "DB01369_MESH_D013290_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000048", "original_object": "GO:0006412"}
{"subject": "GO:0000184", "predicate": "biolink:positively_correlated_with", "object": "HP:0003323", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05016_MESH_D020388_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000184", "original_object": "HP:0003323"}
{"subject": "GO:0000278", "predicate": "biolink:negatively_correlated_with", "object": "GO:0006915", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08871_MESH_D008080_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000278", "original_object": "GO:0006915"}
{"subject": "GO:0000280", "predicate": "biolink:in_taxon", "object": "NCBITaxon:5811", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00205_MESH_D014123_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000280", "original_object": "NCBITaxon:5811"}
{"subject": "GO:0000305", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00911_MESH_D005873_1", "DB00911_MESH_D008101_1", "DB00911_MESH_D014245_1", "DB00911_MESH_D016585_1", "DB11989_MESH_D014355_1", "DB12834_MESH_D005873_1", "DB12834_MESH_D014245_1", "DB12834_MESH_D016585_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000305", "original_object": "MESH:D004247"}
{"subject": "GO:0000380", "predicate": "biolink:produces", "object": "UniProtKB:B4DP61", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13161_MESH_D009134_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000380", "original_object": "UniProtKB:B4DP61"}
{"subject": "GO:0000785", "predicate": "biolink:correlated_with", "object": "GO:0032774", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06810_MESH_D013736_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000785", "original_object": "GO:0032774"}
{"subject": "GO:0001171", "predicate": "biolink:occurs_in", "object": "NCBITaxon:12721", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00300_MESH_D015658_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001171", "original_object": "NCBITaxon:12721"}
{"subject": "GO:0001503", "predicate": "biolink:negatively_correlated_with", "object": "HP:0004349", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06285_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001503", "original_object": "HP:0004349"}
{"subject": "GO:0001503", "predicate": "biolink:correlated_with", "object": "HP:0011849", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01077_MESH_D009999_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001503", "original_object": "HP:0011849"}
{"subject": "GO:0001503", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0043455", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00282_MESH_C562390_1", "DB00399_MESH_C562390_1", "DB01077_MESH_C562390_1", "DB06255_MESH_C562390_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001503", "original_object": "MESH:C562390"}
{"subject": "GO:0001504", "predicate": "biolink:predisposes_to_condition", "object": "HP:0000708", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00206_MESH_D011618_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001504", "original_object": "HP:0000708"}
{"subject": "GO:0001507", "predicate": "biolink:contributes_to", "object": "HP:0001324", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01122_MESH_D009157_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001507", "original_object": "HP:0001324"}
{"subject": "GO:0001507", "predicate": "biolink:affects", "object": "CHEBI:15355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00989_MESH_D000544_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0001507", "original_object": "MESH:D000109"}
{"subject": "GO:0001508", "predicate": "biolink:regulates", "object": "CL:0000197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00527_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0001508", "original_object": "CL:0000197"}
{"subject": "GO:0001516", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:15627", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00945_MESH_D009203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001516", "original_object": "MESH:D013928"}
{"subject": "GO:0001516", "predicate": "biolink:affects", "object": "MESH:D044062", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB07615_MESH_D003876_2", "DB07615_MESH_D065631_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0001516", "original_object": "MESH:D044062"}
{"subject": "GO:0001525", "predicate": "biolink:occurs_in", "object": "CL:0001063", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06626_MESH_D002292_1", "DB06824_MESH_D002292_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001525", "original_object": "CL:0001063"}
{"subject": "GO:0001525", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0024296", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00571_MESH_D006391_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001525", "original_object": "HP:0100742"}
{"subject": "GO:0001525", "predicate": "biolink:occurs_in", "object": "MONDO:0015277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08875_MESH_C536914_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001525", "original_object": "MESH:C536914"}
{"subject": "GO:0001525", "predicate": "biolink:contributes_to", "object": "MONDO:0005086", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09078_MESH_D002292_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001525", "original_object": "MESH:D002292"}
{"subject": "GO:0001631", "predicate": "biolink:regulates", "object": "GO:0006939", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00549_MESH_D001249_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0001631", "original_object": "GO:0006939"}
{"object": "GO:0001631", "predicate": "biolink:has_participant", "subject": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00549_MESH_D001249_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0001631", "original_subject": "GO:0006954"}
{"subject": "GO:0001696", "predicate": "biolink:regulates", "object": "HGNC.FAMILY:1927", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06724_MESH_D004415_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0001696", "original_object": "HGNC.FAMILY:1927"}
{"subject": "GO:0001696", "predicate": "biolink:correlated_with", "object": "MONDO:0009172", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00771_MESH_D004760_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001696", "original_object": "MESH:D004760"}
{"subject": "GO:0001696", "predicate": "biolink:affects", "object": "MESH:D005744", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00213_MESH_D005764_1", "DB00213_MESH_D009377_1", "DB00213_MESH_D010437_1", "DB00213_MESH_D015043_1", "DB00338_MESH_D004381_1", "DB00338_MESH_D004942_1", "DB00338_MESH_D005764_1", "DB00338_MESH_D010437_1", "DB00338_MESH_D013276_1", "DB00338_MESH_D015043_1", "DB00448_MESH_D004381_1", "DB00448_MESH_D005764_1", "DB00448_MESH_D010437_1", "DB00448_MESH_D013276_1", "DB00501_MESH_D004381_1", "DB00501_MESH_D004415_1", "DB00501_MESH_D005764_1", "DB00501_MESH_D006356_1", "DB00501_MESH_D013276_1", "DB00501_MESH_D015043_1", "DB00585_MESH_D004381_1", "DB00585_MESH_D004415_1", "DB00585_MESH_D004942_1", "DB00585_MESH_D005764_1", "DB00585_MESH_D006356_1", "DB00585_MESH_D010437_1", "DB00585_MESH_D013276_1", "DB00863_MESH_D004381_1", "DB00863_MESH_D004415_1", "DB00863_MESH_D005764_1", "DB00863_MESH_D006356_1", "DB00863_MESH_D013276_1", "DB00863_MESH_D015043_1", "DB00927_MESH_D004381_1", "DB00927_MESH_D004415_1", "DB00927_MESH_D004942_1", "DB00927_MESH_D005764_1", "DB00927_MESH_D006356_1", "DB00927_MESH_D013276_1", "DB00927_MESH_D015043_1", "DB01129_MESH_D004381_1", "DB01129_MESH_D009377_1", "DB01129_MESH_D010437_1", "DB01129_MESH_D015043_1", "DB01129_MESH_D034721_1", "DB05351_MESH_D005764_1", "DB05351_MESH_D010437_1", "DB08806_MESH_D005764_1", "DB08806_MESH_D013276_1", "DB08806_MESH_D015043_1", "DB11739_MESH_D004381_1", "DB11739_MESH_D013276_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0001696", "original_object": "MESH:D005744"}
{"subject": "GO:0001696", "predicate": "biolink:positively_correlated_with", "object": "MESH:D005744", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09481_MESH_D003248_1", "DB09481_MESH_D004415_1", "DB09481_MESH_D005764_1", "DB09481_MESH_D006356_1", "DB09481_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001696", "original_object": "MESH:D005744"}
{"subject": "GO:0001696", "predicate": "biolink:treats", "object": "MONDO:0015183", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08900_MESH_D012778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001696", "original_object": "MESH:D012778"}
{"subject": "GO:0001788", "predicate": "biolink:precedes", "object": "GO:0001783", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06650_MESH_D015451_2", "DB08935_MESH_D015451_2", "DB11988_MESH_D020528_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001788", "original_object": "GO:0001783"}
{"subject": "GO:0001821", "predicate": "biolink:regulates", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00716_MESH_D001249_1", "DB00716_MESH_D003233_1", "DB06794_MESH_D003233_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0001821", "original_object": "GO:0006954"}
{"subject": "GO:0002154", "predicate": "biolink:regulates", "object": "GO:0001659", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00279_MESH_D007037_1", "DB00451_MESH_D007037_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0002154", "original_object": "GO:0001659"}
{"subject": "GO:0002154", "predicate": "biolink:positively_correlated_with", "object": "GO:0010460", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00279_MESH_D007037_1", "DB00451_MESH_D007037_1", "DB00451_MESH_D050031_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0002154", "original_object": "GO:0010460"}
{"subject": "GO:0002154", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0001071", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00279_MESH_D003409_1", "DB00451_MESH_D003409_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0002154", "original_object": "HP:0001249"}
{"subject": "GO:0002154", "predicate": "biolink:negatively_correlated_with", "object": "HP:0001252", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00279_MESH_D003409_1", "DB00451_MESH_D003409_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0002154", "original_object": "HP:0001252"}
{"subject": "GO:0002154", "predicate": "biolink:affects", "object": "UniProtKB:P01130", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00451_MESH_D006949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0002154", "original_object": "UniProtKB:P01130"}
{"object": "GO:0002441", "predicate": "biolink:causes", "subject": "NCBITaxon:12059", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00366_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0002441", "original_subject": "NCBITaxon:12059"}
{"subject": "GO:0002553", "predicate": "biolink:regulates", "object": "MONDO:0005492", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00501_MESH_D034721_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0002553", "original_object": "HP:0001025"}
{"subject": "GO:0002553", "predicate": "biolink:regulates", "object": "HP:0012531", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00501_MESH_D034721_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0002553", "original_object": "HP:0012531"}
{"object": "GO:0002561", "predicate": "biolink:causes", "subject": "REACT:R-HSA-2454202", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00043_MESH_D000080223_1", "DB00043_MESH_D001249_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0002561", "original_subject": "REACT:R-HSA-2454202"}
{"subject": "GO:0002947", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0007915", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01708_MESH_D008180_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0002947", "original_object": "MESH:D008180"}
{"subject": "GO:0003092", "predicate": "biolink:contributes_to", "object": "GO:0045777", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00519_MESH_D006973_1", "DB00542_MESH_D006973_1", "DB00584_MESH_D006973_1", "DB01197_MESH_D003928_1", "DB01197_MESH_D006973_1", "DB01348_MESH_D006973_1", "DB09026_MESH_D006973_1", "DB09477_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0003092", "original_object": "GO:0045777"}
{"subject": "GO:0003092", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01324_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0003092", "original_object": "MESH:D006973"}
{"subject": "GO:0003676", "predicate": "biolink:occurs_in", "object": "NCBITaxon:2", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00916_MESH_D018805_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0003676", "original_object": "NCBITaxon:2"}
{"subject": "GO:0003677", "predicate": "biolink:correlated_with", "object": "GO:0006260", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01030_MESH_D010051_1", "DB01030_MESH_D055752_1", "DB12459_MESH_D002289_1", "DB12459_MESH_D010051_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0003677", "original_object": "GO:0006260"}
{"subject": "GO:0003746", "predicate": "biolink:precedes", "object": "GO:0006412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01059_MESH_D004405_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0003746", "original_object": "GO:0006412"}
{"subject": "GO:0003843", "predicate": "biolink:affects", "object": "CHEBI:37163", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00520_MESH_D058387_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0003843", "original_object": "MESH:D005936"}
{"subject": "GO:0003964", "predicate": "biolink:in_taxon", "object": "NCBITaxon:11676", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00649_MESH_D015658_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0003964", "original_object": "NCBITaxon:11676"}
{"subject": "GO:0003990", "predicate": "biolink:affects", "object": "CHEBI:15355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01057_MESH_D000080362_1", "DB01057_MESH_D004948_1", "DB01057_MESH_D005901_1", "DB01057_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0003990", "original_object": "MESH:D000109"}
{"subject": "GO:0004519", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00003_MESH_D003550_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0004519", "original_object": "MESH:D004247"}
{"subject": "GO:0004674", "predicate": "biolink:positively_correlated_with", "object": "GO:0007266", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00619_MESH_D015466_1", "DB04868_MESH_D015466_1", "DB08901_MESH_D015464_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0004674", "original_object": "GO:0007266"}
{"subject": "GO:0004679", "predicate": "biolink:regulates", "object": "GO:0004346", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00331_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004679", "original_object": "GO:0004346"}
{"subject": "GO:0004679", "predicate": "biolink:regulates", "object": "GO:0009331", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00331_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004679", "original_object": "GO:0009331"}
{"subject": "GO:0004679", "predicate": "biolink:affects", "object": "UniProtKB:P14672", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00331_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0004679", "original_object": "UniProtKB:P14672"}
{"subject": "GO:0004714", "predicate": "biolink:regulates", "object": "HP:0031377", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01254_MESH_D001752_1", "DB01254_MESH_D015466_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004714", "original_object": "HP:0031377"}
{"object": "GO:0004714", "predicate": "biolink:has_participant", "subject": "REACT:R-HSA-74713", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09564_MESH_D003920_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0004714", "original_subject": "REACT:R-HSA-74713"}
{"subject": "GO:0004714", "predicate": "biolink:regulates", "object": "UMLS:C2350409", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00046_MESH_D003922_1", "DB00046_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004714", "original_object": "UMLS:C2350409"}
{"subject": "GO:0004908", "predicate": "biolink:regulates", "object": "REACT:R-HSA-1592389", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00026_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004908", "original_object": "REACT:R-HSA-1592389"}
{"subject": "GO:0004948", "predicate": "biolink:regulates", "object": "CL:0000062", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00017_MESH_D010001_1", "DB00017_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004948", "original_object": "CL:0000062"}
{"subject": "GO:0004952", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005485", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06144_MESH_D012559_1", "DB08922_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0004952", "original_object": "HP:0000709"}
{"subject": "GO:0004969", "predicate": "biolink:contributes_to", "object": "MONDO:0005642", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01106_MESH_D003233_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0004969", "original_object": "MESH:D003233"}
{"subject": "GO:0004972", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18237", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01356_MESH_D001171_1", "DB01356_MESH_D001172_1", "DB01356_MESH_D001714_1", "DB01356_MESH_D004412_1", "DB01356_MESH_D010003_1", "DB01356_MESH_D010146_1", "DB01356_MESH_D020773_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0004972", "original_object": "MESH:D018698"}
{"subject": "GO:0005183", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002146", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00624_MESH_D007006_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005183", "original_object": "MESH:D007006"}
{"subject": "GO:0005237", "predicate": "biolink:negatively_correlated_with", "object": "HP:0002360", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00962_MESH_D007319_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005237", "original_object": "HP:0002360"}
{"subject": "GO:0005618", "predicate": "biolink:positively_correlated_with", "object": "GO:0051301", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01000_MESH_D001991_1", "DB01000_MESH_D010612_1", "DB01000_MESH_D014552_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005618", "original_object": "GO:0051301"}
{"subject": "GO:0005618", "predicate": "biolink:occurs_in", "object": "NCBITaxon:1279", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00485_MESH_D011023_1", "DB00713_MESH_D011023_1", "DB00713_MESH_D013203_1", "DB01139_MESH_D011023_1", "DB01326_MESH_D011023_1", "DB01327_MESH_D011023_1", "DB01333_MESH_D011023_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005618", "original_object": "NCBITaxon:1279"}
{"subject": "GO:0005618", "predicate": "biolink:in_taxon", "object": "NCBITaxon:1773", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00609_MESH_D014397_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005618", "original_object": "NCBITaxon:1773"}
{"subject": "GO:0005739", "predicate": "biolink:located_in", "object": "CL:0000198", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06774_MESH_D001416_1", "DB06774_MESH_D009437_1", "DB06774_MESH_D051474_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005739", "original_object": "CL:0000198"}
{"object": "GO:0005764", "predicate": "biolink:has_participant", "subject": "GO:0004558", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01272_MESH_D006009_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0005764", "original_subject": "GO:0004558"}
{"object": "GO:0005840", "predicate": "biolink:has_participant", "subject": "GO:0006412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00314_MESH_D014397_1", "DB08993_MESH_D014397_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0005840", "original_subject": "GO:0006412"}
{"subject": "GO:0005840", "predicate": "biolink:regulates", "object": "GO:0006412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00339_MESH_D014390_1", "DB00339_MESH_D014397_1", "DB00358_MESH_D016780_1", "DB00560_MESH_D011018_1", "DB00560_MESH_D018784_1", "DB00560_MESH_D059413_1", "DB00601_MESH_D011018_1", "DB00601_MESH_D011023_1", "DB00601_MESH_D013203_1", "DB00601_MESH_D013290_1", "DB00618_MESH_D000073605_2", "DB00618_MESH_D000196_1", "DB00618_MESH_D000881_1", "DB00618_MESH_D001991_1", "DB00618_MESH_D002006_1", "DB00618_MESH_D002602_1", "DB00618_MESH_D003235_1", "DB00618_MESH_D006069_1", "DB00618_MESH_D006100_1", "DB00618_MESH_D008219_1", "DB00618_MESH_D009956_1", "DB00618_MESH_D010612_1", "DB00618_MESH_D011014_1", "DB00618_MESH_D011778_1", "DB00618_MESH_D012061_1", "DB00618_MESH_D012373_1", "DB00618_MESH_D012852_1", "DB00618_MESH_D013203_1", "DB00618_MESH_D013587_1", "DB00618_MESH_D014141_1", "DB00618_MESH_D014552_1", "DB00618_MESH_D015001_1", "DB00684_MESH_D000071074_1", "DB00684_MESH_D000077299_1", "DB00684_MESH_D003234_1", "DB00684_MESH_D003607_1", "DB00684_MESH_D004756_1", "DB00684_MESH_D004927_1", "DB00684_MESH_D007637_1", "DB00684_MESH_D011023_1", "DB00684_MESH_D012226_1", "DB00684_MESH_D012393_1", "DB00684_MESH_D013203_1", "DB00684_MESH_D014605_1", "DB00684_MESH_D014606_1", "DB00684_MESH_D016868_1", "DB00684_MESH_D016920_1", "DB00954_MESH_D001991_1", "DB00954_MESH_D010612_1", "DB00954_MESH_D011014_1", "DB00954_MESH_D011018_1", "DB00954_MESH_D011019_1", "DB00954_MESH_D013203_1", "DB00954_MESH_D013290_1", "DB00954_MESH_D014069_1", "DB01211_MESH_D011018_1", "DB01211_MESH_D011019_1", "DB01211_MESH_D013203_1", "DB01211_MESH_D013290_1", "DB01211_MESH_D018410_1", "DB01211_MESH_D061387_1", "DB01764_MESH_D013290_1", "DB09042_MESH_D017192_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0005840", "original_object": "GO:0006412"}
{"object": "GO:0005893", "predicate": "biolink:has_participant", "subject": "GO:0038110", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00111_MESH_D020529_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0005893", "original_subject": "GO:0038110"}
{"subject": "GO:0006006", "predicate": "biolink:occurs_in", "object": "UBERON:0002206", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00152_MESH_D020915_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006006", "original_object": "UBERON:0002206"}
{"subject": "GO:0006171", "predicate": "biolink:preventative_for_condition", "object": "GO:0097279", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00871_MESH_D011537_1", "DB00871_MESH_D011537_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006171", "original_object": "GO:0097279"}
{"subject": "GO:0006182", "predicate": "biolink:affects", "object": "UBERON:0025525", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08890_MESH_D043183_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0006182", "original_object": "UBERON:0025525"}
{"subject": "GO:0006183", "predicate": "biolink:produces", "object": "CHEBI:15996", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00811_MESH_D018357_1", "DB00811_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006183", "original_object": "MESH:D006160"}
{"object": "GO:0006221", "predicate": "biolink:has_participant", "subject": "GO:0050671", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08880_MESH_D009103_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0006221", "original_subject": "GO:0050671"}
{"subject": "GO:0006260", "predicate": "biolink:positively_correlated_with", "object": "CL:0001063", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01030_MESH_D010051_1", "DB01030_MESH_D055752_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006260", "original_object": "CL:0001063"}
{"subject": "GO:0006260", "predicate": "biolink:correlated_with", "object": "GO:0008283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01073_MESH_D015451_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006260", "original_object": "GO:0008283"}
{"object": "GO:0006260", "predicate": "biolink:has_part", "subject": "GO:0042100", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00291_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0006260", "original_subject": "GO:0042100"}
{"subject": "GO:0006260", "predicate": "biolink:occurs_in", "object": "HP:0031377", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00888_MESH_D006689_1", "DB00888_MESH_D008175_1", "DB00888_MESH_D008228_1", "DB00888_MESH_D009182_1", "DB00888_MESH_D011087_1", "DB00888_MESH_D015451_1", "DB00888_MESH_D015464_1", "DB00888_MESH_D016410_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006260", "original_object": "HP:0031377"}
{"subject": "GO:0006260", "predicate": "biolink:precedes", "object": "HP:0031377", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00322_MESH_D008113_1", "DB00432_MESH_D003110_1", "DB01206_MESH_D001932_1", "DB01206_MESH_D006689_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006260", "original_object": "HP:0031377"}
{"object": "GO:0006351", "predicate": "biolink:has_part", "subject": "HP:0031377", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00515_MESH_D010051_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0006351", "original_subject": "HP:0031377"}
{"subject": "GO:0006351", "predicate": "biolink:positively_correlated_with", "object": "UMLS:C0079427", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01262_MESH_D015470_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006351", "original_object": "UMLS:C0079427"}
{"subject": "GO:0006412", "predicate": "biolink:affects", "object": "UniProtKB:A9UF02", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04865_MESH_D015464_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0006412", "original_object": "UniProtKB:A9UF02"}
{"subject": "GO:0006470", "predicate": "biolink:occurs_in", "object": "UMLS:C0027108", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01020_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006470", "original_object": "UMLS:C0027108"}
{"subject": "GO:0006590", "predicate": "biolink:affects", "object": "CHEBI:60311", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00763_MESH_D006980_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0006590", "original_object": "MESH:D013963"}
{"subject": "GO:0006696", "predicate": "biolink:positively_correlated_with", "object": "GO:0009277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01153_MESH_D014008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006696", "original_object": "GO:0009277"}
{"subject": "GO:0006811", "predicate": "biolink:located_in", "object": "GO:0030445", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002179_1", "DB00646_MESH_D002180_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006811", "original_object": "GO:0030445"}
{"subject": "GO:0006833", "predicate": "biolink:located_in", "object": "UBERON:0001155", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09020_MESH_D003248_1", "DB11365_MESH_D003248_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006833", "original_object": "UBERON:0001155"}
{"subject": "GO:0006874", "predicate": "biolink:regulates", "object": "UMLS:C0042404", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00286_MESH_D019584_1", "DB04575_MESH_D019584_1", "DB06401_MESH_D019584_1", "DB06710_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006874", "original_object": "MESH:D014666"}
{"subject": "GO:0006915", "predicate": "biolink:affects", "object": "CL:0000092", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00399_MESH_C562390_1", "DB00399_MESH_D010001_1", "DB00884_MESH_D010001_1", "DB00884_MESH_D010024_1", "DB00884_MESH_D015663_1", "DB01077_MESH_C562390_1", "DB01077_MESH_D010001_1", "DB06255_MESH_C562390_1", "DB06255_MESH_D010024_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0006915", "original_object": "CL:0000092"}
{"subject": "GO:0006939", "predicate": "biolink:manifestation_of", "object": "MONDO:0004979", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00180_MESH_D001249_1", "DB08906_MESH_D001249_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006939", "original_object": "MESH:D001249"}
{"subject": "GO:0006939", "predicate": "biolink:regulates", "object": "UBERON:0005969", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01085_MESH_D005902_1", "DB01085_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006939", "original_object": "UBERON:0005969"}
{"subject": "GO:0006954", "predicate": "biolink:has_phenotype", "object": "HP:0000969", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00223_MESH_D003876_1", "DB00288_MESH_D003876_1", "DB00596_MESH_D003876_1", "DB00663_MESH_D003876_1", "DB00838_MESH_D003876_1", "DB00846_MESH_D003876_1", "DB010473_MESH_D003876_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "HP:0000969"}
{"subject": "GO:0006954", "predicate": "biolink:has_phenotype", "object": "MONDO:0006547", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00223_MESH_D016410_1", "DB00288_MESH_D016410_1", "DB00596_MESH_D016410_1", "DB00663_MESH_D016410_1", "DB00838_MESH_D016410_1", "DB00846_MESH_D016410_1", "DB01047_MESH_D016410_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "HP:0000988"}
{"subject": "GO:0006954", "predicate": "biolink:causes", "object": "MONDO:0850230", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00341_MESH_D000080223_1", "DB00637_MESH_D000080223_1", "DB00967_MESH_D000080223_1", "DB06282_MESH_D000080223_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "MESH:D000080223"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "MESH:D000485", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01620_MESH_D003233_1", "DB01620_MESH_D006255_1", "DB01620_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "MESH:D000485"}
{"object": "GO:0006954", "predicate": "biolink:causes", "subject": "MONDO:0005644", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00634_MESH_D000562_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0006954", "original_subject": "MESH:D000562"}
{"subject": "GO:0006954", "predicate": "biolink:causes", "object": "HP:0003418", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01397_MESH_D001416_1", "DB09543_MESH_D001416_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "MESH:D001416"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "PANTHER.FAMILY:PTHR10078", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08895_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "PANTHER.FAMILY:PTHR10078"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0000403", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00443_MESH_D012536_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "UBERON:0000403"}
{"subject": "GO:0006954", "predicate": "biolink:occurs_in", "object": "UBERON:0001707", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01410_MESH_D001249_1", "DB01410_MESH_D006255_1", "DB01410_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "UBERON:0001707"}
{"subject": "GO:0006954", "predicate": "biolink:located_in", "object": "UBERON:0010061", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00405_MESH_D006255_1", "DB09488_MESH_D006255_1", "DB09488_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "UBERON:0010061"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "UniProtKB:P05231", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08895_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "UniProtKB:P05231"}
{"subject": "GO:0007041", "predicate": "biolink:occurs_in", "object": "GO:0005764", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01272_MESH_D006009_1", "DB13173_MESH_D009472_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007041", "original_object": "GO:0005764"}
{"subject": "GO:0007169", "predicate": "biolink:positively_correlated_with", "object": "HP:0031377", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08875_MESH_C536914_1", "DB08875_MESH_D002292_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007169", "original_object": "HP:0031377"}
{"subject": "GO:0007189", "predicate": "biolink:affects", "object": "GO:0004691", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00374_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0007189", "original_object": "GO:0004691"}
{"subject": "GO:0007195", "predicate": "biolink:affects", "object": "CHEBI:17489", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00248_MESH_D006966_1", "DB00589_MESH_D000568_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0007195", "original_object": "CHEBI:17489"}
{"subject": "GO:0007197", "predicate": "biolink:affects", "object": "MESH:D005744", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00725_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0007197", "original_object": "MESH:D005744"}
{"subject": "GO:0007213", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:15355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00508_MESH_D011618_3", "DB00508_MESH_D011618_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007213", "original_object": "MESH:D000109"}
{"object": "GO:0007259", "predicate": "biolink:has_participant", "subject": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08895_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0007259", "original_subject": "GO:0006954"}
{"subject": "GO:0007259", "predicate": "biolink:regulates", "object": "GO:0019221", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08877_MESH_D009196_1", "DB08877_MESH_D011087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0007259", "original_object": "GO:0019221"}
{"subject": "GO:0007259", "predicate": "biolink:positively_correlated_with", "object": "REACT:R-HSA-1169410", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00105_MESH_C554498_1", "DB00105_MESH_D003218_1", "DB00105_MESH_D019694_1", "DB00105_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007259", "original_object": "REACT:R-HSA-1169410"}
{"subject": "GO:0007266", "predicate": "biolink:negatively_correlated_with", "object": "GO:0006915", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00619_MESH_D015466_1", "DB04868_MESH_D015466_1", "DB08901_MESH_D015464_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007266", "original_object": "GO:0006915"}
{"subject": "GO:0007268", "predicate": "biolink:regulates", "object": "UniProtKB:P06881", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06283_MESH_D059350_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0007268", "original_object": "UniProtKB:P06881"}
{"subject": "GO:0007269", "predicate": "biolink:affects", "object": "GO:0060081", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01433_MESH_D009293_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "GO:0007269", "original_object": "GO:0060081"}
{"object": "GO:0007269", "predicate": "biolink:has_participant", "subject": "HP:0012514", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08872_MESH_D012148_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0007269", "original_subject": "HP:0012514"}
{"subject": "GO:0007274", "predicate": "biolink:precedes", "object": "MONDO:0005395", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00376_MESH_D020734_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007274", "original_object": "HP:0100022"}
{"subject": "GO:0007596", "predicate": "biolink:has_output", "object": "UBERON:0010210", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01418_MESH_D011655_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007596", "original_object": "UBERON:0010210"}
{"subject": "GO:0007613", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0004975", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00843_MESH_D000544_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007613", "original_object": "MESH:D000544"}
{"subject": "GO:0008213", "predicate": "biolink:disrupts", "object": "UMLS:C1136102", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03843_MESH_D007251_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008213", "original_object": "UMLS:C1136102"}
{"subject": "GO:0008237", "predicate": "biolink:affects", "object": "GO:0031012", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00287_MESH_D005902_1", "DB00287_MESH_D009798_1", "DB00654_MESH_D005902_1", "DB00654_MESH_D009798_1", "DB08819_MESH_D005902_1", "DB08819_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0008237", "original_object": "GO:0031012"}
{"subject": "GO:0008283", "predicate": "biolink:precedes", "object": "CL:0001063", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04845_MESH_D001943_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008283", "original_object": "CL:0001063"}
{"subject": "GO:0008398", "predicate": "biolink:negatively_correlated_with", "object": "CHEBI:16521", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06636_MESH_D001228_1", "DB06636_MESH_D009091_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008398", "original_object": "CHEBI:16521"}
{"subject": "GO:0008511", "predicate": "biolink:negatively_correlated_with", "object": "GO:0035812", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00695_MESH_D004487_1", "DB00903_MESH_D004487_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008511", "original_object": "GO:0035812"}
{"subject": "GO:0008900", "predicate": "biolink:located_in", "object": "UBERON:0000325", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00736_MESH_D005764_1", "DB01129_MESH_D005764_1", "DB11964_MESH_D005764_1", "DB11964_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008900", "original_object": "UBERON:0000325"}
{"subject": "GO:0009273", "predicate": "biolink:has_output", "object": "GO:0005618", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00485_MESH_D011023_1", "DB00485_MESH_D013203_1", "DB00713_MESH_D010612_1", "DB00713_MESH_D011023_1", "DB00713_MESH_D012852_1", "DB00713_MESH_D013203_1", "DB01000_MESH_D001991_1", "DB01000_MESH_D010612_1", "DB01000_MESH_D014552_1", "DB01060_MESH_D004927_1", "DB01060_MESH_D007710_1", "DB01060_MESH_D010612_1", "DB01060_MESH_D011018_1", "DB01060_MESH_D012226_1", "DB01060_MESH_D013203_1", "DB01060_MESH_D013290_1", "DB01060_MESH_D014552_1", "DB01060_MESH_D018410_1", "DB01139_MESH_D004697_1", "DB01139_MESH_D004927_1", "DB01139_MESH_D011014_1", "DB01139_MESH_D011018_1", "DB01139_MESH_D011023_1", "DB01139_MESH_D012226_1", "DB01139_MESH_D013203_1", "DB01139_MESH_D013290_1", "DB01139_MESH_D014552_1", "DB01326_MESH_D004756_1", "DB01326_MESH_D004927_1", "DB01326_MESH_D011014_1", "DB01326_MESH_D011018_1", "DB01326_MESH_D011023_1", "DB01326_MESH_D013203_1", "DB01326_MESH_D013290_1", "DB01326_MESH_D014552_1", "DB01326_MESH_D059413_1", "DB01327_MESH_D002761_1", "DB01327_MESH_D004697_1", "DB01327_MESH_D011018_1", "DB01327_MESH_D011023_1", "DB01327_MESH_D018410_1", "DB01328_MESH_D011014_1", "DB01328_MESH_D011018_1", "DB01328_MESH_D013203_1", "DB01328_MESH_D013290_1", "DB01328_MESH_D014552_1", "DB01333_MESH_D010612_1", "DB01333_MESH_D011018_1", "DB01333_MESH_D011023_1", "DB01333_MESH_D011472_1", "DB01333_MESH_D013203_1", "DB01333_MESH_D014069_1", "DB01333_MESH_D014552_1", "DB01602_MESH_D006069_1", "DB01602_MESH_D010612_1", "DB01602_MESH_D012852_1", "DB01602_MESH_D014552_1", "DB06211_MESH_D002764_1", "DB06211_MESH_D011704_1", "DB06211_MESH_D018784_1", "DB06211_MESH_D059413_1", "DB06590_MESH_D004927_1", "DB06590_MESH_D012226_1", "DB06590_MESH_D013203_1", "DB06590_MESH_D013290_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009273", "original_object": "GO:0005618"}
{"object": "GO:0009274", "predicate": "biolink:has_part", "subject": "NCBITaxon:2", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05245_MESH_D012883_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0009274", "original_subject": "NCBITaxon:2"}
{"subject": "GO:0009277", "predicate": "biolink:correlated_with", "object": "MONDO:0002041", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01263_MESH_D009181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009277", "original_object": "MESH:D009181"}
{"subject": "GO:0010737", "predicate": "biolink:regulates", "object": "GO:0071159", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00806_MESH_D016491_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0010737", "original_object": "GO:0071159"}
{"subject": "GO:0014047", "predicate": "biolink:positively_correlated_with", "object": "GO:0004952", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06144_MESH_D012559_1", "DB08922_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0014047", "original_object": "GO:0004952"}
{"object": "GO:0015464", "predicate": "biolink:disrupts", "subject": "MONDO:0009688", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01400_MESH_D009157_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0015464", "original_subject": "MESH:D009157"}
{"subject": "GO:0015842", "predicate": "biolink:positively_correlated_with", "object": "REACT:R-HSA-212676", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04844_MESH_D006816_1", "DB11915_MESH_D000071057_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015842", "original_object": "REACT:R-HSA-212676"}
{"object": "GO:0015934", "predicate": "biolink:has_part", "subject": "GO:0005840", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00618_MESH_D000073605_2", "DB00618_MESH_D000196_1", "DB00618_MESH_D000881_1", "DB00618_MESH_D001991_1", "DB00618_MESH_D002006_1", "DB00618_MESH_D002602_1", "DB00618_MESH_D003235_1", "DB00618_MESH_D006069_1", "DB00618_MESH_D006100_1", "DB00618_MESH_D008219_1", "DB00618_MESH_D009956_1", "DB00618_MESH_D010612_1", "DB00618_MESH_D011014_1", "DB00618_MESH_D011778_1", "DB00618_MESH_D012061_1", "DB00618_MESH_D012373_1", "DB00618_MESH_D012852_1", "DB00618_MESH_D013203_1", "DB00618_MESH_D013587_1", "DB00618_MESH_D014141_1", "DB00618_MESH_D014552_1", "DB00618_MESH_D015001_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0015934", "original_subject": "GO:0005840"}
{"subject": "GO:0016209", "predicate": "biolink:preventative_for_condition", "object": "HP:0025610", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00137_MESH_D000080343_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0016209", "original_object": "MESH:D000080343"}
{"subject": "GO:0016209", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0003004", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00137_MESH_D008268_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0016209", "original_object": "MESH:D008268"}
{"subject": "GO:0016616", "predicate": "biolink:regulates", "object": "CHEBI:26333", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02329_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0016616", "original_object": "MESH:D011453"}
{"subject": "GO:0016887", "predicate": "biolink:affects", "object": "CL:0000092", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00884_MESH_D010001_1", "DB00884_MESH_D010024_1", "DB00884_MESH_D015663_1", "DB01077_MESH_C562390_1", "DB01077_MESH_D010001_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0016887", "original_object": "CL:0000092"}
{"subject": "GO:0016917", "predicate": "biolink:treats", "object": "MONDO:0021107", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09072_MESH_D009290_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0016917", "original_object": "MESH:D009290"}
{"subject": "GO:0018104", "predicate": "biolink:contributes_to", "object": "GO:0005618", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01333_MESH_D012141_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0018104", "original_object": "GO:0005618"}
{"subject": "GO:0019221", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0020076", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08877_MESH_D009196_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019221", "original_object": "MESH:D009196"}
{"subject": "GO:0019228", "predicate": "biolink:regulates", "object": "GO:0023041", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00617_MESH_D004827_1", "DB00617_MESH_D004832_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0019228", "original_object": "GO:0023041"}
{"subject": "GO:0019233", "predicate": "biolink:manifestation_of", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01086_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019233", "original_object": "MESH:D011537"}
{"object": "GO:0019277", "predicate": "biolink:has_part", "subject": "GO:0009274", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00828_MESH_D014552_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0019277", "original_subject": "GO:0009274"}
{"subject": "GO:0019369", "predicate": "biolink:regulates", "object": "GO:0005886", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00711_MESH_D004604_1", "DB00711_MESH_D008118_1", "DB00711_MESH_D009855_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019369", "original_object": "GO:0005886"}
{"object": "GO:0019767", "predicate": "biolink:has_part", "subject": "UniProtKB:P01854", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00043_MESH_D000080223_1", "DB00043_MESH_D001249_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0019767", "original_subject": "UniProtKB:P01854"}
{"subject": "GO:0022848", "predicate": "biolink:located_in", "object": "GO:0031594", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00411_MESH_D005902_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0022848", "original_object": "GO:0031594"}
{"subject": "GO:0022851", "predicate": "biolink:correlated_with", "object": "MONDO:0005618", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09166_MESH_D001008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0022851", "original_object": "MESH:D001008"}
{"subject": "GO:0023041", "predicate": "biolink:located_in", "object": "UBERON:0000004", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00341_MESH_D012912_1", "DB00434_MESH_D012912_1", "DB00434_MESH_D012912_2", "DB00637_MESH_D012912_1", "DB00950_MESH_D012912_1", "DB08799_MESH_D012912_1", "DB09488_MESH_D012912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0023041", "original_object": "UBERON:0000004"}
{"subject": "GO:0030073", "predicate": "biolink:regulates", "object": "MESH:D001786", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01382_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0030073", "original_object": "MESH:D001786"}
{"subject": "GO:0030218", "predicate": "biolink:has_output", "object": "CL:0000232", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00016_MESH_D000740_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030218", "original_object": "CL:0000232"}
{"subject": "GO:0030520", "predicate": "biolink:treats", "object": "MONDO:0001196", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01708_MESH_D004414_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030520", "original_object": "MESH:D004414"}
{"subject": "GO:0030520", "predicate": "biolink:treats", "object": "HP:0031217", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00603_MESH_D019584_1", "DB00957_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030520", "original_object": "MESH:D019584"}
{"subject": "GO:0031012", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00287_MESH_D005902_1", "DB00287_MESH_D009798_1", "DB00654_MESH_D005902_1", "DB00654_MESH_D009798_1", "DB08819_MESH_D005902_1", "DB08819_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0031012", "original_object": "UBERON:0001796"}
{"subject": "GO:0031424", "predicate": "biolink:affects", "object": "HP:0025249", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00257_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0031424", "original_object": "HP:0025249"}
{"subject": "GO:0031594", "predicate": "biolink:positively_correlated_with", "object": "HP:0000616", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00411_MESH_D005902_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0031594", "original_object": "HP:0000616"}
{"subject": "GO:0032869", "predicate": "biolink:related_to", "object": "GO:0001951", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09198_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0032869", "original_object": "GO:0001951"}
{"subject": "GO:0032993", "predicate": "biolink:has_participant", "object": "UniProtKB:P11388", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00445_MESH_D001943_1", "DB00694_MESH_D004915_1", "DB00694_MESH_D007948_1", "DB00694_MESH_D012514_1", "DB00694_MESH_D015470_1", "DB00694_MESH_D015473_1", "DB01177_MESH_D015470_1", "DB01177_MESH_D015473_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0032993", "original_object": "UniProtKB:P11388"}
{"subject": "GO:0033764", "predicate": "biolink:produces", "object": "CHEBI:16330", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05812_MESH_D011471_6"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0033764", "original_object": "CHEBI:16330"}
{"subject": "GO:0034599", "predicate": "biolink:capable_of", "object": "GO:0008219", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00262_MESH_D001932_1", "DB00262_MESH_D005910_1", "DB00262_MESH_D006689_1", "DB00262_MESH_D008228_1", "DB00262_MESH_D009101_1", "DB00262_MESH_D016403_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0034599", "original_object": "GO:0008219"}
{"subject": "GO:0034776", "predicate": "biolink:affects", "object": "GO:0007186", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09488_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0034776", "original_object": "GO:0007186"}
{"subject": "GO:0035623", "predicate": "biolink:preventative_for_condition", "object": "HP:0003076", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08907_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0035623", "original_object": "HP:0003076"}
{"subject": "GO:0035623", "predicate": "biolink:correlated_with", "object": "MESH:D001786", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11824_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0035623", "original_object": "MESH:D001786"}
{"subject": "GO:0038060", "predicate": "biolink:contributes_to", "object": "GO:0042311", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08931_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0038060", "original_object": "GO:0042311"}
{"subject": "GO:0038169", "predicate": "biolink:regulates", "object": "MONDO:0019933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06791_MESH_D000172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0038169", "original_object": "MESH:D000172"}
{"subject": "GO:0038169", "predicate": "biolink:regulates", "object": "UniProtKB:P01241", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00104_MESH_D000172_1", "DB00104_MESH_D008303_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0038169", "original_object": "UniProtKB:P01241"}
{"subject": "GO:0042310", "predicate": "biolink:negatively_correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00449_MESH_D005902_1", "DB00668_MESH_D005902_1", "DB00668_MESH_D005902_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042310", "original_object": "UBERON:0001796"}
{"subject": "GO:0042311", "predicate": "biolink:ameliorates_condition", "object": "HP:0001681", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01020_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042311", "original_object": "MESH:D000787"}
{"subject": "GO:0042438", "predicate": "biolink:produces", "object": "MESH:C041877", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04931_MESH_D046351_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042438", "original_object": "MESH:C041877"}
{"subject": "GO:0042775", "predicate": "biolink:regulates", "object": "GO:0004679", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00331_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0042775", "original_object": "GO:0004679"}
{"subject": "GO:0042802", "predicate": "biolink:causes", "object": "GO:0051262", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05352_MESH_D000686_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042802", "original_object": "GO:0051262"}
{"subject": "GO:0043627", "predicate": "biolink:treats", "object": "HP:0031217", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00783_MESH_D019584_1", "DB00977_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0043627", "original_object": "MESH:D019584"}
{"subject": "GO:0045851", "predicate": "biolink:disrupts", "object": "NCBITaxon:287", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03166_MESH_D010032_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0045851", "original_object": "NCBITaxon:287"}
{"subject": "GO:0046911", "predicate": "biolink:contributes_to", "object": "GO:0004857", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01188_MESH_D002179_1", "DB01188_MESH_D012628_1", "DB01188_MESH_D014008_1", "DB01188_MESH_D014009_1", "DB01188_MESH_D014010_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0046911", "original_object": "GO:0004857"}
{"subject": "GO:0050806", "predicate": "biolink:actively_involved_in", "object": "GO:1904058", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00564_MESH_D014277_1", "DB00564_MESH_D020435_1", "DB00645_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0050806", "original_object": "GO:1904058"}
{"object": "GO:0050892", "predicate": "biolink:disrupts", "subject": "MONDO:0100345", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13761_MESH_D007787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0050892", "original_subject": "MESH:D007787"}
{"object": "GO:0051262", "predicate": "biolink:disrupts", "subject": "GO:0043243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05352_MESH_D000686_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0051262", "original_subject": "GO:0043243"}
{"subject": "GO:0051607", "predicate": "biolink:affects", "object": "NCBITaxon:10566", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00724_MESH_D003218_1", "DB00724_MESH_D014860_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0051607", "original_object": "NCBITaxon:10566"}
{"subject": "GO:0060077", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0100577", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09118_MESH_D004831_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060077", "original_object": "MESH:D004831"}
{"subject": "GO:0060081", "predicate": "biolink:related_to", "object": "MONDO:0005530", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01433_MESH_D009293_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060081", "original_object": "HP:0033515"}
{"object": "GO:0060096", "predicate": "biolink:has_part", "subject": "UBERON:0025593", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00924_MESH_D009128_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0060096", "original_subject": "UBERON:0025593"}
{"subject": "GO:0060612", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D005230", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060612", "original_object": "MESH:D005230"}
{"subject": "GO:0060636", "predicate": "biolink:disrupts", "object": "GO:0030445", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01141_MESH_D058387_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060636", "original_object": "GO:0030445"}
{"object": "GO:0061527", "predicate": "biolink:affects", "subject": "MONDO:0011918", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00831_MESH_D001007_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0061527", "original_subject": "MESH:D001007"}
{"subject": "GO:0070254", "predicate": "biolink:related_to", "object": "HP:0031245", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06767_MESH_D003139_1", "DB06767_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0070254", "original_object": "HP:0031245"}
{"subject": "GO:0071159", "predicate": "biolink:regulates", "object": "GO:0002947", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01708_MESH_D008180_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0071159", "original_object": "GO:0002947"}
{"subject": "GO:0071159", "predicate": "biolink:affects", "object": "UniProtKB:P02741", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00806_MESH_D016491_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0071159", "original_object": "UniProtKB:P02741"}
{"object": "GO:0090559", "predicate": "biolink:has_participant", "subject": "GO:0022803", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00027_MESH_D003234_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0090559", "original_subject": "GO:0022803"}
{"subject": "GO:0097746", "predicate": "biolink:correlated_with", "object": "UMLS:C0042404", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00286_MESH_D019584_1", "DB06401_MESH_D019584_1", "DB06710_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0097746", "original_object": "MESH:D014666"}
{"subject": "GO:0099565", "predicate": "biolink:in_taxon", "object": "NCBITaxon:6248", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00602_MESH_D013322_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0099565", "original_object": "NCBITaxon:6248"}
{"subject": "HGNC.FAMILY:1109", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0011438", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09096_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:1109", "original_object": "MESH:D000152"}
{"object": "HGNC.FAMILY:1203", "predicate": "biolink:has_participant", "subject": "GO:0005248", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00645_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HGNC.FAMILY:1203", "original_subject": "GO:0005248"}
{"subject": "HGNC.FAMILY:1203", "predicate": "biolink:regulates", "object": "GO:0006814", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09085_MESH_D011537_1", "DB09345_MESH_D005076_1", "DB09345_MESH_D006484_1", "DB09345_MESH_D010032_1", "DB09345_MESH_D011349_1", "DB09345_MESH_D011537_1", "DB09345_MESH_D011538_1", "DB09345_MESH_D014008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "HGNC.FAMILY:1203", "original_object": "GO:0006814"}
{"subject": "HGNC.FAMILY:1203", "predicate": "biolink:positively_correlated_with", "object": "GO:0051899", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00273_MESH_D004828_1", "DB00273_MESH_D004830_1", "DB00273_MESH_D065768_1", "DB00564_MESH_D004827_1", "DB00564_MESH_D004828_1", "DB00564_MESH_D004830_1", "DB00564_MESH_D012640_1", "DB00564_MESH_D014277_1", "DB00564_MESH_D020435_1", "DB00564_MESH_D065768_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:1203", "original_object": "GO:0051899"}
{"subject": "HGNC.FAMILY:1203", "predicate": "biolink:regulates", "object": "GO:0086060", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01228_MESH_D018879_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "HGNC.FAMILY:1203", "original_object": "GO:0086060"}
{"subject": "HGNC.FAMILY:1203", "predicate": "biolink:affects", "object": "CHEBI:26708", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01182_MESH_D001281_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "transport", "original_subject": "HGNC.FAMILY:1203", "original_object": "MESH:D012964"}
{"object": "HGNC.FAMILY:171", "predicate": "biolink:has_participant", "subject": "GO:0051610", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00656_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HGNC.FAMILY:171", "original_subject": "GO:0051610"}
{"subject": "HGNC.FAMILY:173", "predicate": "biolink:regulates", "object": "HP:0007906", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00981_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "HGNC.FAMILY:173", "original_object": "HP:0007906"}
{"object": "HGNC.FAMILY:175", "predicate": "biolink:has_participant", "subject": "REACT:R-HSA-629587", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00184_MESH_D014029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HGNC.FAMILY:175", "original_subject": "REACT:R-HSA-629587"}
{"subject": "HGNC.FAMILY:180", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:15355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00458_MESH_D053206_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:180", "original_object": "CHEBI:15355"}
{"subject": "HGNC.FAMILY:180", "predicate": "biolink:regulates", "object": "GO:0007213", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01239_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "HGNC.FAMILY:180", "original_object": "GO:0007213"}
{"subject": "HGNC.FAMILY:180", "predicate": "biolink:affects", "object": "GO:0046541", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01085_MESH_D014987_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "HGNC.FAMILY:180", "original_object": "GO:0046541"}
{"subject": "HGNC.FAMILY:180", "predicate": "biolink:treats", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00835_MESH_D011537_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:180", "original_object": "MESH:D011537"}
{"subject": "HGNC.FAMILY:181", "predicate": "biolink:negatively_correlated_with", "object": "HP:0002071", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01186_MESH_D020734_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:181", "original_object": "HP:0002071"}
{"subject": "HGNC.FAMILY:181", "predicate": "biolink:correlated_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01621_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:181", "original_object": "MESH:D004298"}
{"subject": "HGNC.FAMILY:184", "predicate": "biolink:positively_correlated_with", "object": "HP:0012531", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06742_MESH_D010612_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:184", "original_object": "HP:0012531"}
{"subject": "HGNC.FAMILY:1927", "predicate": "biolink:contributes_to", "object": "MONDO:0007186", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06724_MESH_D004415_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:1927", "original_object": "HP:0002020"}
{"subject": "HGNC.FAMILY:2086", "predicate": "biolink:affects", "object": "UniProtKB:P15090", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "HGNC.FAMILY:2086", "original_object": "UniProtKB:P15090"}
{"subject": "HGNC.FAMILY:211", "predicate": "biolink:located_in", "object": "CL:0000542", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00563_MESH_D001171_1", "DB00563_MESH_D001172_1", "DB00563_MESH_D011565_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:211", "original_object": "CL:0000542"}
{"subject": "HGNC.FAMILY:245", "predicate": "biolink:negatively_correlated_with", "object": "GO:0060004", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00318_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:245", "original_object": "GO:0060004"}
{"subject": "HGNC.FAMILY:404", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR11716", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D016410_1", "DB00240_MESH_D016460_1", "DB01234_MESH_C562390_1", "DB01234_MESH_D000744_1", "DB01234_MESH_D000799_1", "DB01234_MESH_D001172_1", "DB01234_MESH_D001249_1", "DB01234_MESH_D001607_1", "DB01234_MESH_D001929_1", "DB01234_MESH_D002051_1", "DB01234_MESH_D002062_1", "DB01234_MESH_D003233_1", "DB01234_MESH_D003320_1", "DB01234_MESH_D003424_1", "DB01234_MESH_D003873_1", "DB01234_MESH_D003874_1", "DB01234_MESH_D003876_1", "DB01234_MESH_D003877_1", "DB01234_MESH_D004892_1", "DB01234_MESH_D005076_1", "DB01234_MESH_D005128_1", "DB01234_MESH_D006689_1", "DB01234_MESH_D007500_1", "DB01234_MESH_D007627_1", "DB01234_MESH_D007634_1", "DB01234_MESH_D007819_1", "DB01234_MESH_D008179_1", "DB01234_MESH_D008180_1", "DB01234_MESH_D008224_1", "DB01234_MESH_D008228_1", "DB01234_MESH_D009101_1", "DB01234_MESH_D009103_1", "DB01234_MESH_D009140_1", "DB01234_MESH_D009182_1", "DB01234_MESH_D009404_1", "DB01234_MESH_D009450_1", "DB01234_MESH_D010032_1", "DB01234_MESH_D010392_1", "DB01234_MESH_D011538_1", "DB01234_MESH_D011565_1", "DB01234_MESH_D011657_1", "DB01234_MESH_D012214_1", "DB01234_MESH_D012393_1", "DB01234_MESH_D012507_1", "DB01234_MESH_D012628_1", "DB01234_MESH_D012713_1", "DB01234_MESH_D012871_1", "DB01234_MESH_D013167_1", "DB01234_MESH_D013716_1", "DB01234_MESH_D013717_2", "DB01234_MESH_D013966_1", "DB01234_MESH_D014235_1", "DB01234_MESH_D014391_1", "DB01234_MESH_D014605_1", "DB01234_MESH_D014606_1", "DB01234_MESH_D015210_1", "DB01234_MESH_D015212_1", "DB01234_MESH_D015535_1", "DB01234_MESH_D015863_1", "DB01234_MESH_D016403_1", "DB01234_MESH_D016410_1", "DB01234_MESH_D016460_1", "DB01234_MESH_D029503_1", "DB01234_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "HGNC.FAMILY:404", "original_object": "PANTHER.FAMILY:PTHR11716"}
{"subject": "HP:0000017", "predicate": "biolink:manifestation_of", "object": "HP:0100518", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00237_MESH_D053159_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000017", "original_object": "MESH:D053159"}
{"subject": "MONDO:0002473", "predicate": "biolink:manifestation_of", "object": "MONDO:0004691", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06212_MESH_D016891_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000107", "original_object": "MESH:D016891"}
{"subject": "MONDO:0001836", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0000088", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00666_MESH_D011629_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000141", "original_object": "MESH:D011629"}
{"subject": "HP:0000282", "predicate": "biolink:manifestation_of", "object": "MONDO:0010481", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00902_MESH_D000799_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000282", "original_object": "MESH:D000799"}
{"subject": "HP:0000616", "predicate": "biolink:negatively_correlated_with", "object": "HP:0007663", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01057_MESH_D000080362_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000616", "original_object": "HP:0007663"}
{"subject": "HP:0000616", "predicate": "biolink:negatively_correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01057_MESH_D005901_1", "DB01057_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000616", "original_object": "UBERON:0001796"}
{"subject": "MONDO:0002320", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0024298", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00115_MESH_D001361_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000707", "original_object": "MESH:D001361"}
{"subject": "HP:0000708", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005485", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00206_MESH_D011618_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000708", "original_object": "MESH:D011618"}
{"subject": "MONDO:0005485", "predicate": "biolink:occurs_in", "object": "MONDO:0005180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05316_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000709", "original_object": "MESH:D010300"}
{"subject": "HP:0000713", "predicate": "biolink:occurs_in", "object": "MONDO:0004985", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01356_MESH_D001714_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000713", "original_object": "MESH:D001714"}
{"subject": "MONDO:0002050", "predicate": "biolink:contributes_to", "object": "MONDO:0004985", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00334_MESH_D001714_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000716", "original_object": "MESH:D001714"}
{"subject": "MONDO:0002050", "predicate": "biolink:correlated_with", "object": "MONDO:0002050", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00934_MESH_D003866_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000716", "original_object": "MESH:D003866"}
{"subject": "MONDO:0005044", "predicate": "biolink:contributes_to", "object": "HP:0001714", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00571_MESH_D002312_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000822", "original_object": "HP:0001714"}
{"subject": "MONDO:0005044", "predicate": "biolink:positively_correlated_with", "object": "HP:0001681", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00571_MESH_D000787_1", "DB04846_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000822", "original_object": "MESH:D000787"}
{"subject": "MONDO:0005044", "predicate": "biolink:predisposes_to_condition", "object": "HP:0001681", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01580_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000822", "original_object": "MESH:D000787"}
{"subject": "MONDO:0005044", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005016", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00678_MESH_D003928_1", "DB01197_MESH_D003928_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000822", "original_object": "MESH:D003928"}
{"subject": "HP:0000969", "predicate": "biolink:correlated_with", "object": "UMLS:C0520676", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D065446_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000969", "original_object": "MESH:D065446"}
{"subject": "HP:0000989", "predicate": "biolink:positively_correlated_with", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00825_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000989", "original_object": "MESH:D011537"}
{"subject": "HP:0000989", "predicate": "biolink:contributes_to", "object": "MONDO:0005984", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00443_MESH_D014008_1", "DB00741_MESH_D014008_1", "DB01380_MESH_D014008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000989", "original_object": "MESH:D014008"}
{"subject": "HP:0000989", "predicate": "biolink:located_in", "object": "UBERON:0001245", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00388_MESH_D011538_1", "DB00443_MESH_D011538_1", "DB00588_MESH_D011538_1", "DB00620_MESH_D011538_1", "DB00741_MESH_D011538_1", "DB00860_MESH_D011538_1", "DB00959_MESH_D011538_1", "DB01260_MESH_D011538_1", "DB01380_MESH_D011538_1", "DB14512_MESH_D011538_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000989", "original_object": "UBERON:0001245"}
{"subject": "HP:0001033", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002046", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00822_MESH_D000437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001033", "original_object": "MESH:D000437"}
{"subject": "MONDO:0005027", "predicate": "biolink:manifestation_of", "object": "HP:0002133", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00312_MESH_D013226_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001250", "original_object": "MESH:D013226"}
{"subject": "HP:0001257", "predicate": "biolink:negatively_correlated_with", "object": "GO:0022414", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00848_MESH_D000724_1", "DB00848_MESH_D001196_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001257", "original_object": "GO:0022414"}
{"object": "MONDO:0005578", "predicate": "biolink:subclass_of", "subject": "MONDO:0008383", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09276_MESH_D001171_1", "DB09276_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HP:0001369", "original_subject": "HP:0001370"}
{"subject": "HP:0001387", "predicate": "biolink:contributes_to", "object": "HP:0002829", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00201_MESH_D018771_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001387", "original_object": "MESH:D018771"}
{"subject": "HP:0001950", "predicate": "biolink:causes", "object": "MONDO:0006625", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00819_MESH_D000532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001950", "original_object": "MESH:D000532"}
{"subject": "MONDO:0100326", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0031332", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00036_MESH_D013915_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001975", "original_object": "MESH:D013915"}
{"subject": "HP:0002069", "predicate": "biolink:in_taxon", "object": "NCBITaxon:52283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00431_MESH_D012532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002069", "original_object": "NCBITaxon:52283"}
{"subject": "MONDO:0002012", "predicate": "biolink:causes", "object": "MONDO:0002320", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00115_MESH_D001361_1", "DB00115_MESH_D014806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002912", "original_object": "HP:0000707"}
{"object": "MONDO:0001566", "predicate": "biolink:causes", "subject": "UMLS:C0070099", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00443_MESH_C562390_1", "DB00620_MESH_C562390_1", "DB00635_MESH_C562390_1", "DB00741_MESH_C562390_1", "DB00860_MESH_C562390_1", "DB00959_MESH_C562390_1", "DB01380_MESH_C562390_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HP:0003072", "original_subject": "MESH:D044162"}
{"subject": "HP:0003076", "predicate": "biolink:affects", "object": "MESH:D001786", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08907_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "HP:0003076", "original_object": "MESH:D001786"}
{"subject": "MONDO:0006496", "predicate": "biolink:in_taxon", "object": "NCBITaxon:51028", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00592_MESH_D017229_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0003470", "original_object": "NCBITaxon:51028"}
{"subject": "MONDO:0006496", "predicate": "biolink:occurs_in", "object": "NCBITaxon:6181", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01058_MESH_D012552_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0003470", "original_object": "NCBITaxon:6181"}
{"object": "HP:0004324", "predicate": "biolink:subclass_of", "subject": "MONDO:0011122", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01083_MESH_D009765_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HP:0004324", "original_subject": "MESH:D009765"}
{"object": "HP:0004363", "predicate": "biolink:subclass_of", "subject": "HP:0002901", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00146_MESH_D006996_1", "DB00146_MESH_D012080_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HP:0004363", "original_subject": "HP:0002901"}
{"subject": "HP:0007906", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005338", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00287_MESH_D005902_1", "DB00654_MESH_D005902_1", "DB01214_MESH_D005902_1", "DB08819_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0007906", "original_object": "MESH:D005902"}
{"subject": "HP:0007906", "predicate": "biolink:treats", "object": "MONDO:0005338", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09013_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0007906", "original_object": "MESH:D005902"}
{"subject": "HP:0011104", "predicate": "biolink:contributes_to", "object": "GO:0045777", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00232_MESH_D006973_1", "DB00310_MESH_D006973_1", "DB00436_MESH_D006973_1", "DB00524_MESH_D006973_2", "DB00695_MESH_D006973_1", "DB00808_MESH_D006973_1", "DB00999_MESH_D006973_1", "DB02925_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0011104", "original_object": "GO:0045777"}
{"subject": "HP:0011104", "predicate": "biolink:causes", "object": "HP:0000969", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00232_MESH_D004487_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0011104", "original_object": "MESH:D004487"}
{"subject": "HP:0012535", "predicate": "biolink:correlated_with", "object": "HP:0002121", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00347_MESH_D004832_2", "DB05246_MESH_D004832_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012535", "original_object": "HP:0002121"}
{"subject": "HP:0025464", "predicate": "biolink:positively_correlated_with", "object": "GO:0150076", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08842_MESH_D000544_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0025464", "original_object": "GO:0150076"}
{"subject": "HP:0031245", "predicate": "biolink:treats", "object": "HP:0012735", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06767_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0031245", "original_object": "MESH:D003371"}
{"subject": "HP:0031245", "predicate": "biolink:affects", "object": "UBERON:0016553", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00874_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "HP:0031245", "original_object": "UBERON:0016553"}
{"subject": "HP:0031377", "predicate": "biolink:located_in", "object": "CL:0000236", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00997_MESH_D008224_1", "DB00997_MESH_D016403_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0031377", "original_object": "CL:0000236"}
{"subject": "HP:0031377", "predicate": "biolink:located_in", "object": "UBERON:0002465", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00997_MESH_D002051_1", "DB00997_MESH_D008228_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0031377", "original_object": "UBERON:0002465"}
{"subject": "HP:0031826", "predicate": "biolink:precedes", "object": "HP:0003394", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00924_MESH_D009128_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0031826", "original_object": "HP:0003394"}
{"subject": "MONDO:0005530", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005530", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01433_MESH_D009293_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0033515", "original_object": "MESH:D009293"}
{"subject": "MONDO:0005594", "predicate": "biolink:positively_correlated_with", "object": "GO:0097709", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06811_MESH_D014648_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0100699", "original_object": "GO:0097709"}
{"subject": "CHEBI:192761", "predicate": "biolink:affects", "object": "CHEBI:18367", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09146_MESH_D054559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:C000599459", "original_object": "CHEBI:18367"}
{"subject": "MESH:C000600172", "predicate": "biolink:regulates", "object": "UniProtKB:P05093", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05812_MESH_D011471_5"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C000600172", "original_object": "UniProtKB:P05093"}
{"subject": "UNII:70KO0R01RY", "predicate": "biolink:affects", "object": "CHEBI:29103", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01344_MESH_D006947_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:C003321", "original_object": "CHEBI:29103"}
{"subject": "UMLS:C0009315", "predicate": "biolink:disrupts", "object": "GO:0061701", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01111_MESH_D004927_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C004691", "original_object": "GO:0061701"}
{"subject": "CHEBI:31699", "predicate": "biolink:affects", "object": "MESH:D009539", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08949_MESH_D010383_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:C005193", "original_object": "MESH:D009539"}
{"subject": "MESH:C005435", "predicate": "biolink:subclass_of", "object": "CHEBI:63726", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12243_MESH_D000690_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C005435", "original_object": "CHEBI:63726"}
{"subject": "UNII:0E53J927NA", "predicate": "biolink:subclass_of", "object": "CHEBI:65265", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09481_MESH_D003248_1", "DB09481_MESH_D004415_1", "DB09481_MESH_D005764_1", "DB09481_MESH_D006356_1", "DB09481_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C005479", "original_object": "MESH:D000863"}
{"subject": "CHEBI:134806", "predicate": "biolink:regulates", "object": "UBERON:0000912", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13163_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C005804", "original_object": "UBERON:0000912"}
{"subject": "MESH:C006632", "predicate": "biolink:negatively_correlated_with", "object": "GO:0001525", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01169_MESH_D015473_1", "DB01169_MESH_D015479_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C006632", "original_object": "GO:0001525"}
{"subject": "MESH:C006632", "predicate": "biolink:disrupts", "object": "UMLS:C0029014", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01169_MESH_D015473_1", "DB01169_MESH_D015479_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C006632", "original_object": "UMLS:C0029014"}
{"subject": "UNII:LIU00Z1Z84", "predicate": "biolink:treats", "object": "MONDO:0015129", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00741_MESH_D000224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C007133", "original_object": "MESH:D000224"}
{"subject": "CHEBI:31186", "predicate": "biolink:directly_physically_interacts_with", "object": "UniProtKB:O15528", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01436_MESH_D006961_1", "DB01436_MESH_D007011_1", "DB01436_MESH_D007011_2", "DB01436_MESH_D007011_3", "DB01436_MESH_D012080_1", "DB01436_MESH_D012080_2", "DB01436_MESH_D012080_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C008088", "original_object": "UniProtKB:O15528"}
{"subject": "CHEBI:46859", "predicate": "biolink:chemically_similar_to", "object": "MESH:D012597", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06811_MESH_D014648_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C008976", "original_object": "MESH:D012597"}
{"subject": "MESH:C011585", "predicate": "biolink:disrupts", "object": "GO:0005886", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01188_MESH_D002179_1", "DB01188_MESH_D012628_1", "DB01188_MESH_D014008_1", "DB01188_MESH_D014009_1", "DB01188_MESH_D014010_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C011585", "original_object": "GO:0005886"}
{"subject": "MESH:C011585", "predicate": "biolink:capable_of", "object": "GO:0046911", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01188_MESH_D002179_1", "DB01188_MESH_D012628_1", "DB01188_MESH_D014008_1", "DB01188_MESH_D014009_1", "DB01188_MESH_D014010_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C011585", "original_object": "GO:0046911"}
{"subject": "CHEBI:261649", "predicate": "biolink:produces", "object": "CHEBI:16914", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01294_MESH_D003967_1", "DB01294_MESH_D004415_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C015715", "original_object": "MESH:D020156"}
{"subject": "CHEBI:141517", "predicate": "biolink:capable_of", "object": "GO:0043129", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06439_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C016811", "original_object": "GO:0043129"}
{"subject": "CHEBI:50815", "predicate": "biolink:regulates", "object": "UBERON:0004092", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00957_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C017576", "original_object": "UBERON:0004092"}
{"subject": "CHEBI:34683", "predicate": "biolink:regulates", "object": "GO:0120054", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09449_MESH_D003248_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C018279", "original_object": "GO:0120054"}
{"subject": "CHEBI:87184", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:18059", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03808_MESH_D015823_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C018961", "original_object": "CHEBI:18059"}
{"subject": "MESH:C019248", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:52255", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00282_MESH_C562390_1", "DB00282_MESH_D010001_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C019248", "original_object": "CHEBI:52255"}
{"object": "CHEBI:9679", "predicate": "biolink:derives_from", "subject": "CHEBI:22984", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11348_MESH_D006996_1", "DB11348_MESH_D010024_1", "DB11348_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:C020243", "original_subject": "MESH:D002118"}
{"subject": "CHEBI:31184", "predicate": "biolink:negatively_correlated_with", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D016410_1", "DB00240_MESH_D016460_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C021137", "original_object": "CHEBI:18295"}
{"subject": "CHEBI:31184", "predicate": "biolink:negatively_correlated_with", "object": "UMLS:C0079189", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D016410_1", "DB00240_MESH_D016460_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C021137", "original_object": "UMLS:C0079189"}
{"subject": "UNII:Q5EN532NE7", "predicate": "biolink:preventative_for_condition", "object": "GO:0090592", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01280_MESH_D054218_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C022206", "original_object": "GO:0090592"}
{"object": "CHEBI:30745", "predicate": "biolink:has_part", "subject": "UMLS:C0070627", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09269_MESH_D022124_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:C025136", "original_subject": "MESH:C003089"}
{"subject": "PUBCHEM.COMPOUND:10255482", "predicate": "biolink:disrupts", "object": "GO:0032774", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09256_MESH_D013274_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C025635", "original_object": "GO:0032774"}
{"subject": "CHEBI:135934", "predicate": "biolink:disrupts", "object": "NCBITaxon:55194", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00971_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C025698", "original_object": "NCBITaxon:55194"}
{"subject": "UMLS:C0063134", "predicate": "biolink:regulates", "object": "GO:0003676", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00916_MESH_D018805_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C029371", "original_object": "GO:0003676"}
{"subject": "UMLS:C0065191", "predicate": "biolink:positively_correlated_with", "object": "HP:0003124", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08949_MESH_D006937_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C032607", "original_object": "MESH:D006937"}
{"subject": "UMLS:C0065191", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0007759", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08949_MESH_D006950_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C032607", "original_object": "MESH:D006950"}
{"subject": "CHEBI:135152", "predicate": "biolink:affects", "object": "GO:0051620", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08998_MESH_D003866_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:C033781", "original_object": "GO:0051620"}
{"subject": "MESH:C036006", "predicate": "biolink:has_metabolite", "object": "CHEBI:701", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00776_MESH_D004828_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C036006", "original_object": "CHEBI:701"}
{"subject": "CHEBI:75283", "predicate": "biolink:disrupts", "object": "CHEBI:16247", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09031_MESH_D007897_1", "DB09031_MESH_D007898_1", "DB09031_MESH_D016773_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C039128", "original_object": "CHEBI:16247"}
{"subject": "UNII:2XH88IXE7W", "predicate": "biolink:disrupts", "object": "PANTHER.FAMILY:PTHR11817", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12864_MESH_D014353_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C044719", "original_object": "PANTHER.FAMILY:PTHR11817"}
{"subject": "MESH:C044919", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:29034", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08826_MESH_D017086_1", "DB08826_MESH_D019190_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C044919", "original_object": "CHEBI:29034"}
{"subject": "CHEBI:78539", "predicate": "biolink:has_metabolite", "object": "UMLS:C0085065", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13166_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C044958", "original_object": "MESH:C065520"}
{"subject": "UMLS:C0066924", "predicate": "biolink:located_in", "object": "UBERON:0001199", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C047874", "original_object": "MESH:D005753"}
{"subject": "CHEBI:32090", "predicate": "biolink:negatively_correlated_with", "object": "CHEBI:26519", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11656_MESH_D005756_1", "DB11656_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C052785", "original_object": "MESH:D005609"}
{"subject": "UNII:3X11EVM5SU", "predicate": "biolink:affects", "object": "PANTHER.FAMILY:PTHR22935", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00447_MESH_D001991_1", "DB00447_MESH_D011014_1", "DB00447_MESH_D011018_1", "DB00447_MESH_D012141_1", "DB00447_MESH_D013290_1", "DB00447_MESH_D014069_1", "DB00447_MESH_D014552_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:C054920", "original_object": "PANTHER.FAMILY:PTHR22935"}
{"subject": "CHEBI:63452", "predicate": "biolink:negatively_correlated_with", "object": "REACT:R-HSA-9607240", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06595_MESH_D007946_1", "DB06595_MESH_D015470_1", "DB06595_MESH_D034721_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C059539", "original_object": "REACT:R-HSA-9607240"}
{"subject": "UMLS:C0051846", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:64628", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06791_MESH_D000172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C060347", "original_object": "MESH:D013004"}
{"subject": "UMLS:C0078737", "predicate": "biolink:negatively_correlated_with", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09221_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C061957", "original_object": "GO:0006954"}
{"subject": "UMLS:C0078737", "predicate": "biolink:positively_correlated_with", "object": "GO:0042060", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09221_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C061957", "original_object": "GO:0042060"}
{"subject": "UMLS:C0078737", "predicate": "biolink:negatively_correlated_with", "object": "NCBITaxon:210", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09221_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C061957", "original_object": "NCBITaxon:210"}
{"subject": "CHEBI:31889", "predicate": "biolink:negatively_correlated_with", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12447_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C062127", "original_object": "UBERON:0001866"}
{"subject": "UNII:S866O45PIG", "predicate": "biolink:chemically_similar_to", "object": "UBERON:0008826", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06761_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C072197", "original_object": "UBERON:0008826"}
{"subject": "MESH:C078049", "predicate": "biolink:regulates", "object": "GO:0009340", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01044_MESH_D003234_1", "DB01044_MESH_D018410_1", "DB01044_MESH_D061387_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C078049", "original_object": "GO:0009340"}
{"subject": "UMLS:C0211023", "predicate": "biolink:directly_physically_interacts_with", "object": "UniProtKB:P01589", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00004_MESH_D016410_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C078456", "original_object": "UniProtKB:P01589"}
{"subject": "CHEBI:72999", "predicate": "biolink:capable_of", "object": "GO:0043129", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09114_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C081581", "original_object": "GO:0043129"}
{"subject": "UNII:04NQ160FRU", "predicate": "biolink:regulates", "object": "CL:0000062", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11093_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C081587", "original_object": "MESH:D010006"}
{"subject": "UNII:3A189DH42V", "predicate": "biolink:directly_physically_interacts_with", "object": "UniProtKB:P31358", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00087_MESH_D020529_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C096529", "original_object": "UniProtKB:P31358"}
{"object": "CHEBI:4534", "predicate": "biolink:has_metabolite", "subject": "PUBCHEM.COMPOUND:174173", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01501_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:C100010", "original_subject": "MESH:C028792"}
{"subject": "CHEBI:5614", "predicate": "biolink:disrupts", "object": "GO:0005886", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00793_MESH_D014008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C100276", "original_object": "GO:0005886"}
{"subject": "UMLS:C0391001", "predicate": "biolink:regulates", "object": "UniProtKB:P17181", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00008_MESH_D019698_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C100416", "original_object": "UniProtKB:P17181"}
{"subject": "CHEBI:30907", "predicate": "biolink:contributes_to", "object": "MONDO:0005155", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00348_MESH_D020176_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C105171", "original_object": "HP:0001394"}
{"subject": "CHEBI:135829", "predicate": "biolink:has_metabolite", "object": "CHEBI:9763", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09335_MESH_D011018_1", "DB09335_MESH_D011019_1", "DB09335_MESH_D011023_2", "DB09335_MESH_D014552_1", "DB09335_MESH_D059413_1", "DB09335_MESH_D061387_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C106856", "original_object": "DRUGBANK:DB00685"}
{"subject": "UNII:Q4K217VGA9", "predicate": "biolink:capable_of", "object": "GO:0043129", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06415_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C117342", "original_object": "GO:0043129"}
{"subject": "CHEBI:3310", "predicate": "biolink:contraindicated_in", "object": "MONDO:0000745", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00258_MESH_D006323_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C120662", "original_object": "MESH:D006323"}
{"subject": "UNII:4Q52C550XK", "predicate": "biolink:coexists_with", "object": "MESH:D015021", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C422802", "original_object": "MESH:D015021"}
{"subject": "UNII:4Q52C550XK", "predicate": "biolink:physically_interacts_with", "object": "UniProtKB:P11836", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C422802", "original_object": "UniProtKB:P11836"}
{"subject": "CHEBI:83353", "predicate": "biolink:chemically_similar_to", "object": "UniProtKB:P06280", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00103_MESH_D000795_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C459420", "original_object": "UniProtKB:P06280"}
{"subject": "CHEBI:72690", "predicate": "biolink:regulates", "object": "CL:0000092", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08910_MESH_D009101_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C467566", "original_object": "CL:0000092"}
{"subject": "UMLS:C1172636", "predicate": "biolink:disrupts", "object": "CHEBI:8005", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06219_MESH_D013207_1", "DB06219_MESH_D017192_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C469289", "original_object": "CHEBI:8005"}
{"object": "MESH:C508864", "predicate": "biolink:has_participant", "subject": "GO:0003943", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01279_MESH_D009087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:C508864", "original_subject": "GO:0003943"}
{"subject": "CHEBI:94805", "predicate": "biolink:positively_correlated_with", "object": "UniProtKB:P11532", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05016_MESH_D020388_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C515878", "original_object": "UniProtKB:P11532"}
{"subject": "UNII:7XL5ISS668", "predicate": "biolink:coexists_with", "object": "UNII:V7I58RC5EJ", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08870_MESH_D006689_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C547738", "original_object": "MESH:C495575"}
{"subject": "UNII:43K1W2T1M6", "predicate": "biolink:directly_physically_interacts_with", "object": "UniProtKB:P17181", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00105_MESH_C554498_1", "DB00105_MESH_D003218_1", "DB00105_MESH_D007943_1", "DB00105_MESH_D008224_1", "DB00105_MESH_D008545_1", "DB00105_MESH_D019694_1", "DB00105_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C554127", "original_object": "UniProtKB:P17181"}
{"object": "CHEBI:134745", "predicate": "biolink:derives_from", "subject": "CHEBI:75316", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08909_MESH_D056806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:C570223", "original_subject": "CHEBI:75316"}
{"subject": "CHEBI:74895", "predicate": "biolink:positively_correlated_with", "object": "GO:0035861", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08913_MESH_D011471_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C581106", "original_object": "GO:0035861"}
{"object": "UMLS:C3849397", "predicate": "biolink:has_participant", "subject": "GO:0007596", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11607_MESH_D006467_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:C587014", "original_subject": "GO:0007596"}
{"subject": "CHEBI:8869", "predicate": "biolink:negatively_correlated_with", "object": "GO:0016887", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00884_MESH_D010001_1", "DB00884_MESH_D010024_1", "DB00884_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000068296", "original_object": "GO:0016887"}
{"subject": "CHEBI:63625", "predicate": "biolink:has_active_ingredient", "object": "PUBCHEM.COMPOUND:5481180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00300_MESH_D015658_1", "DB00300_MESH_D019694_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000068698", "original_object": "MESH:C583447"}
{"subject": "UMLS:C0289884", "predicate": "biolink:regulates", "object": "GO:0042613", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05259_MESH_D009103_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D000068717", "original_object": "GO:0042613"}
{"subject": "UNII:2P471X1Z11", "predicate": "biolink:affects", "object": "GO:0019767", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00043_MESH_D000080223_1", "DB00043_MESH_D001249_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D000069444", "original_object": "GO:0019767"}
{"subject": "CHEBI:331697", "predicate": "biolink:affects", "object": "GO:0004972", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00289_MESH_D001289_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D000069445", "original_object": "GO:0004972"}
{"subject": "UMLS:C1530450", "predicate": "biolink:disrupts", "object": "UniProtKB:O14788", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06643_MESH_D010024_1", "DB06643_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000069448", "original_object": "UniProtKB:O14788"}
{"subject": "UNII:981Y8SX18M", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06769_MESH_D008224_1", "DB06769_MESH_D015451_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000069461", "original_object": "MESH:D004247"}
{"subject": "CHEBI:59594", "predicate": "biolink:affects", "object": "CHEBI:47774", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00930_MESH_D006937_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D000069472", "original_object": "CHEBI:47774"}
{"subject": "CHEBI:63631", "predicate": "biolink:affects", "object": "GO:0022851", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00273_MESH_D004828_1", "DB00273_MESH_D004830_1", "DB00273_MESH_D065768_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D000077236", "original_object": "GO:0022851"}
{"subject": "CHEBI:53258", "predicate": "biolink:disrupts", "object": "UBERON:0000912", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09154_MESH_D003139_1", "DB09154_MESH_D003371_1", "DB09154_MESH_D012220_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000077559", "original_object": "UBERON:0000912"}
{"subject": "UMLS:C0872968", "predicate": "biolink:has_metabolite", "object": "MESH:D000080084", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00056_MESH_D015470_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000079982", "original_object": "MESH:D000080084"}
{"subject": "CHEBI:15355", "predicate": "biolink:contributes_to", "object": "GO:0032224", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00733_MESH_D062025_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000109", "original_object": "GO:0032224"}
{"subject": "CHEBI:15355", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0004975", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00382_MESH_D000544_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000109", "original_object": "MESH:D000544"}
{"subject": "CHEBI:28939", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06151_MESH_D001987_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000111", "original_object": "GO:0006954"}
{"subject": "CHEBI:15422", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5661", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05630_MESH_D007896_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000255", "original_object": "NCBITaxon:5661"}
{"subject": "CHEBI:27584", "predicate": "biolink:contributes_to", "object": "HP:0032263", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09279_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000450", "original_object": "HP:0032263"}
{"object": "CHEBI:27584", "predicate": "biolink:has_participant", "subject": "HP:0032263", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00700_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:D000450", "original_subject": "HP:0032263"}
{"subject": "MESH:D000485", "predicate": "biolink:contributes_to", "object": "MONDO:0005642", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01620_MESH_D003233_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000485", "original_object": "MESH:D003233"}
{"subject": "CHEBI:135590", "predicate": "biolink:regulates", "object": "GO:0038060", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06742_MESH_D010612_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D000551", "original_object": "GO:0038060"}
{"subject": "CHEBI:31206", "predicate": "biolink:interacts_with", "object": "UBERON:0000410", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06767_MESH_D003139_1", "DB06767_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000643", "original_object": "UBERON:0000410"}
{"subject": "CHEBI:2682", "predicate": "biolink:regulates", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00681_MESH_C536777_1", "DB00681_MESH_D000152_1", "DB00681_MESH_D001228_1", "DB00681_MESH_D001759_1", "DB00681_MESH_D001991_1", "DB00681_MESH_D002177_1", "DB00681_MESH_D002179_1", "DB00681_MESH_D002180_1", "DB00681_MESH_D003047_1", "DB00681_MESH_D003235_1", "DB00681_MESH_D003453_1", "DB00681_MESH_D003963_1", "DB00681_MESH_D006660_1", "DB00681_MESH_D007896_1", "DB00681_MESH_D007898_1", "DB00681_MESH_D009091_1", "DB00681_MESH_D010612_1", "DB00681_MESH_D011014_1", "DB00681_MESH_D012852_1", "DB00681_MESH_D014552_1", "DB00681_MESH_D016921_1", "DB00681_MESH_D055744_1", "DB00681_MESH_D058387_1", "DB00681_MESH_D059413_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D000666", "original_object": "MESH:D004875"}
{"subject": "CHEBI:50113", "predicate": "biolink:regulates", "object": "CL:0000317", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00957_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D000728", "original_object": "CL:0000317"}
{"subject": "CHEBI:65265", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D005744", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09104_MESH_D004415_1", "DB09104_MESH_D005764_1", "DB09104_MESH_D006356_1", "DB09104_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000863", "original_object": "MESH:D005744"}
{"subject": "CHEBI:35441", "predicate": "biolink:ameliorates_condition", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03255_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000890", "original_object": "MESH:D011537"}
{"subject": "CHEBI:82405", "predicate": "biolink:regulates", "object": "NCBITaxon:1747", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09096_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D001585", "original_object": "NCBITaxon:1747"}
{"subject": "CHEBI:22984", "predicate": "biolink:preventative_for_condition", "object": "HP:0002901", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00326_MESH_D006996_1", "DB13142_MESH_D006996_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002118", "original_object": "MESH:D006996"}
{"subject": "CHEBI:3371", "predicate": "biolink:affects", "object": "GO:0005840", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00314_MESH_D014397_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D002207", "original_object": "GO:0005840"}
{"subject": "CHEBI:27644", "predicate": "biolink:affects", "object": "MESH:D054680", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09093_MESH_D014141_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D002751", "original_object": "MESH:D054680"}
{"subject": "CHEBI:3655", "predicate": "biolink:affects", "object": "HP:0031826", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00356_MESH_D009128_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D002753", "original_object": "HP:0031826"}
{"subject": "CHEBI:16113", "predicate": "biolink:occurs_in", "object": "HP:0011980", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06777_MESH_D002769_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002784", "original_object": "HP:0011980"}
{"subject": "CHEBI:16113", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0002277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00175_MESH_D001161_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002784", "original_object": "MESH:D001161"}
{"subject": "UNII:4B33BGI082", "predicate": "biolink:regulates", "object": "CHEBI:138366", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01432_MESH_D006937_1", "DB01432_MESH_D006949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D002792", "original_object": "MESH:D001647"}
{"subject": "CHEBI:15640", "predicate": "biolink:chemically_similar_to", "object": "PUBCHEM.COMPOUND:135402046", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00650_MESH_D000749_2", "DB00650_MESH_D005494_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002955", "original_object": "MESH:C030371"}
{"subject": "CHEBI:28694", "predicate": "biolink:positively_correlated_with", "object": "PANTHER.FAMILY:PTHR10078", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D003300", "original_object": "PANTHER.FAMILY:PTHR10078"}
{"subject": "CHEBI:27666", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00970_MESH_D009396_1", "DB00970_MESH_D012208_1", "DB00970_MESH_D012512_1", "DB00970_MESH_D013736_1", "DB00970_MESH_D031901_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D003609", "original_object": "MESH:D004247"}
{"subject": "CHEBI:41977", "predicate": "biolink:contributes_to", "object": "GO:0140713", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00694_MESH_D004915_1", "DB00694_MESH_D007948_1", "DB00694_MESH_D012514_1", "DB00694_MESH_D015470_1", "DB00694_MESH_D015473_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D003630", "original_object": "GO:0140713"}
{"subject": "CHEBI:16991", "predicate": "biolink:occurs_in", "object": "CL:0000084", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01204_MESH_D020529_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004247", "original_object": "CL:0000084"}
{"subject": "CHEBI:16991", "predicate": "biolink:occurs_in", "object": "MONDO:0005058", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05109_MESH_D007890_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004247", "original_object": "MESH:D007890"}
{"subject": "CHEBI:18243", "predicate": "biolink:correlated_with", "object": "MONDO:0002050", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00334_MESH_D001714_1", "DB00334_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004298", "original_object": "HP:0000716"}
{"subject": "CHEBI:4784", "predicate": "biolink:produces", "object": "UMLS:C0014027", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00584_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004656", "original_object": "MESH:D015773"}
{"subject": "CHEBI:16933", "predicate": "biolink:positively_correlated_with", "object": "GO:0005886", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01167_MESH_C536777_1", "DB01167_MESH_D001228_1", "DB01167_MESH_D001759_1", "DB01167_MESH_D006660_1", "DB01167_MESH_D055744_1", "DB01167_MESH_D058387_1", "DB01167_MESH_D060585_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004875", "original_object": "GO:0005886"}
{"subject": "CHEBI:16933", "predicate": "biolink:regulates", "object": "GO:0009277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00681_MESH_C536777_1", "DB00681_MESH_D000152_1", "DB00681_MESH_D001228_1", "DB00681_MESH_D001759_1", "DB00681_MESH_D001991_1", "DB00681_MESH_D002177_1", "DB00681_MESH_D002179_1", "DB00681_MESH_D002180_1", "DB00681_MESH_D003047_1", "DB00681_MESH_D003235_1", "DB00681_MESH_D003453_1", "DB00681_MESH_D003963_1", "DB00681_MESH_D006660_1", "DB00681_MESH_D007896_1", "DB00681_MESH_D007898_1", "DB00681_MESH_D009091_1", "DB00681_MESH_D010612_1", "DB00681_MESH_D011014_1", "DB00681_MESH_D012852_1", "DB00681_MESH_D014552_1", "DB00681_MESH_D016921_1", "DB00681_MESH_D055744_1", "DB00681_MESH_D058387_1", "DB00681_MESH_D059413_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D004875", "original_object": "GO:0009277"}
{"subject": "CHEBI:50114", "predicate": "biolink:regulates", "object": "GO:0030284", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01217_MESH_D001943_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D004967", "original_object": "GO:0030284"}
{"subject": "CHEBI:50114", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0001410", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04938_MESH_D004414_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004967", "original_object": "MESH:D059268"}
{"subject": "CHEBI:77035", "predicate": "biolink:affects", "object": "UBERON:0016553", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00874_MESH_D003139_1", "DB00874_MESH_D012220_1", "DB00874_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D005100", "original_object": "UBERON:0016553"}
{"subject": "MESH:D005230", "predicate": "biolink:contributes_to", "object": "HP:0000855", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005230", "original_object": "HP:0000855"}
{"subject": "CHEBI:27470", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0001700", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00650_MESH_D000749_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005492", "original_object": "MESH:D000749"}
{"subject": "CHEBI:27470", "predicate": "biolink:has_metabolite", "object": "CHEBI:67016", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00158_MESH_D001361_1", "DB00158_MESH_D005494_1", "DB00158_MESH_D018798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005492", "original_object": "MESH:D013763"}
{"subject": "CHEBI:26519", "predicate": "biolink:positively_correlated_with", "object": "GO:0036480", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12131_MESH_D003704_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005609", "original_object": "GO:0036480"}
{"subject": "CHEBI:26519", "predicate": "biolink:disrupts", "object": "HP:0011355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00855_MESH_D055623_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005609", "original_object": "HP:0011355"}
{"subject": "CHEBI:16865", "predicate": "biolink:regulates", "object": "MONDO:0018097", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01080_MESH_D013036_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D005680", "original_object": "MESH:D013036"}
{"subject": "MESH:D005744", "predicate": "biolink:regulates", "object": "HGNC.FAMILY:1927", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00338_MESH_D004381_1", "DB00338_MESH_D013276_1", "DB00424_MESH_D010437_1", "DB00505_MESH_D010437_1", "DB00505_MESH_D013276_1", "DB00927_MESH_D004381_1", "DB00927_MESH_D013276_1", "DB00927_MESH_D015043_1", "DB00986_MESH_D010437_1", "DB01625_MESH_D010437_1", "DB06723_MESH_D004381_1", "DB06723_MESH_D010437_1", "DB06723_MESH_D013276_1", "DB08806_MESH_D013276_1", "DB08806_MESH_D015043_1", "DB11098_MESH_D010437_1", "DB11739_MESH_D004381_1", "DB11739_MESH_D013276_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D005744", "original_object": "HGNC.FAMILY:1927"}
{"subject": "MESH:D005744", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0007186", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00213_MESH_D005764_1", "DB00338_MESH_D005764_1", "DB00448_MESH_D005764_1", "DB01377_MESH_D004415_1", "DB05351_MESH_D005764_1", "DB06723_MESH_D004415_1", "DB06723_MESH_D005764_1", "DB06723_MESH_D006356_1", "DB09104_MESH_D004415_1", "DB09104_MESH_D005764_1", "DB09104_MESH_D006356_1", "DB09154_MESH_D004415_1", "DB09154_MESH_D005764_1", "DB09154_MESH_D006356_1", "DB09281_MESH_D004415_1", "DB09281_MESH_D005764_1", "DB09281_MESH_D006356_1", "DB09481_MESH_D003248_1", "DB09481_MESH_D004415_1", "DB09481_MESH_D005764_1", "DB09481_MESH_D006356_1", "DB09481_MESH_D010437_1", "DB11098_MESH_D004415_1", "DB11098_MESH_D005764_1", "DB11098_MESH_D006356_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005744", "original_object": "HP:0002020"}
{"subject": "MESH:D005744", "predicate": "biolink:contributes_to", "object": "MONDO:0004247", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00383_MESH_D010437_1", "DB00448_MESH_D010437_1", "DB00501_MESH_D004381_1", "DB00501_MESH_D013276_1", "DB00501_MESH_D015043_1", "DB00585_MESH_D010437_1", "DB00670_MESH_D010437_1", "DB00725_MESH_D010437_1", "DB00747_MESH_D010437_1", "DB00782_MESH_D010437_1", "DB00863_MESH_D004381_1", "DB00863_MESH_D013276_1", "DB00863_MESH_D015043_1", "DB00940_MESH_D010437_1", "DB04843_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005744", "original_object": "HP:0004398"}
{"subject": "MESH:D005744", "predicate": "biolink:correlated_with", "object": "MONDO:0002268", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00585_MESH_D004415_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005744", "original_object": "MESH:D004415"}
{"subject": "MESH:D005744", "predicate": "biolink:located_in", "object": "UBERON:0001043", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09087_MESH_D005764_1", "DB09087_MESH_D006356_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005744", "original_object": "UBERON:0001043"}
{"subject": "UBERON:0001199", "predicate": "biolink:produces", "object": "UBERON:0000912", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005753", "original_object": "UBERON:0000912"}
{"subject": "CHEBI:36500", "predicate": "biolink:causes", "object": "MONDO:0018150", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04878_MESH_D005776_1", "DB06720_MESH_D005776_1", "DB08876_MESH_D005776_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005963", "original_object": "MESH:D005776"}
{"subject": "UMLS:C0017797", "predicate": "biolink:produces", "object": "CL:0000584", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00130_MESH_D012778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005973", "original_object": "CL:0000584"}
{"subject": "CHEBI:18085", "predicate": "biolink:occurs_in", "object": "GO:0005764", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01279_MESH_D009087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006025", "original_object": "GO:0005764"}
{"subject": "CHEBI:18085", "predicate": "biolink:manifestation_of", "object": "MONDO:0001586", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00090_MESH_D008059_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006025", "original_object": "MESH:D008059"}
{"subject": "CHEBI:50385", "predicate": "biolink:disrupts", "object": "CL:0000232", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12975_MESH_D016778_2", "DB12975_MESH_D016780_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006427", "original_object": "CL:0000232"}
{"subject": "CHEBI:18295", "predicate": "biolink:affects", "object": "CL:0000540", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01114_MESH_D012912_1", "DB06691_MESH_D012912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D006632", "original_object": "CL:0000540"}
{"object": "CHEBI:18295", "predicate": "biolink:has_participant", "subject": "MONDO:0007817", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00748_MESH_D003233_2", "DB00748_MESH_D006255_1", "DB00748_MESH_D065631_1", "DB01075_MESH_D003233_1", "DB01075_MESH_D006255_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:D006632", "original_subject": "MESH:D006969"}
{"subject": "CHEBI:17650", "predicate": "biolink:produces", "object": "UNII:LIU00Z1Z84", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00741_MESH_C562390_1", "DB00741_MESH_D000224_1", "DB00741_MESH_D000309_1", "DB00741_MESH_D000744_1", "DB00741_MESH_D001249_1", "DB00741_MESH_D001327_1", "DB00741_MESH_D003873_1", "DB00741_MESH_D003874_1", "DB00741_MESH_D005076_1", "DB00741_MESH_D008228_1", "DB00741_MESH_D009140_1", "DB00741_MESH_D011015_1", "DB00741_MESH_D011565_1", "DB00741_MESH_D012507_1", "DB00741_MESH_D013585_1", "DB00741_MESH_D013966_1", "DB00741_MESH_D015210_1", "DB00741_MESH_D015535_1", "DB00741_MESH_D052256_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006854", "original_object": "MESH:C007133"}
{"subject": "CHEBI:27786", "predicate": "biolink:affects", "object": "CHEBI:30411", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00200_MESH_D000752_1", "DB00200_MESH_D014806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D006879", "original_object": "CHEBI:30411"}
{"subject": "CHEBI:5801", "predicate": "biolink:negatively_correlated_with", "object": "HGNC.FAMILY:1296", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01611_MESH_D001172_1", "DB01611_MESH_D008179_1", "DB01611_MESH_D008180_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006886", "original_object": "HGNC.FAMILY:1296"}
{"subject": "UBERON:0002466", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0005052", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08890_MESH_D043183_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D007419", "original_object": "MESH:D043183"}
{"subject": "CHEBI:74460", "predicate": "biolink:affects", "object": "NCBITaxon:4751", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04815_MESH_D014008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D007464", "original_object": "NCBITaxon:4751"}
{"subject": "UMLS:C0022478", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:3165", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06718_MESH_D054179_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D007610", "original_object": "PUBCHEM.COMPOUND:439201"}
{"subject": "CHEBI:50176", "predicate": "biolink:affects", "object": "HP:0025249", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00257_MESH_D000152_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D007641", "original_object": "HP:0025249"}
{"subject": "UMLS:C0023607", "predicate": "biolink:positively_correlated_with", "object": "GO:0005183", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00624_MESH_D007006_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D007986", "original_object": "GO:0005183"}
{"subject": "UMLS:C0023607", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0001836", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00644_MESH_D000568_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D007986", "original_object": "MESH:D000568"}
{"subject": "UMLS:C0023821", "predicate": "biolink:negatively_correlated_with", "object": "HP:0003124", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00627_MESH_D006937_1", "DB01039_MESH_D006937_1", "DB01039_MESH_D006949_1", "DB01039_MESH_D006950_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008075", "original_object": "HP:0003124"}
{"subject": "CHEBI:39026", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0002277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00175_MESH_D001161_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008077", "original_object": "MESH:D001161"}
{"subject": "CHEBI:6637", "predicate": "biolink:subclass_of", "object": "UMLS:C0282090", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09104_MESH_D003248_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008276", "original_object": "UMLS:C0282090"}
{"subject": "CHEBI:32599", "predicate": "biolink:positively_correlated_with", "object": "PANTHER.FAMILY:PTHR19384", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00653_MESH_D003248_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008278", "original_object": "PANTHER.FAMILY:PTHR19384"}
{"subject": "CHEBI:32599", "predicate": "biolink:positively_correlated_with", "object": "UniProtKB:P06307", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00653_MESH_D003248_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008278", "original_object": "UniProtKB:P06307"}
{"subject": "MONDO:0020598", "predicate": "biolink:negatively_correlated_with", "object": "GO:0006879", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00115_MESH_D018798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008286", "original_object": "GO:0006879"}
{"subject": "UMLS:C0025241", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01042_MESH_D009101_1", "DB01042_MESH_D010051_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008558", "original_object": "MESH:D004247"}
{"subject": "CHEBI:27436", "predicate": "biolink:precedes", "object": "CHEBI:34179", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06710_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008777", "original_object": "CHEBI:34179"}
{"subject": "CHEBI:6942", "predicate": "biolink:produces", "object": "CL:0000346", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00350_MESH_D000505_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008914", "original_object": "CL:0000346"}
{"subject": "CHEBI:17303", "predicate": "biolink:contraindicated_in", "object": "HP:0001945", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00318_MESH_D005334_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009020", "original_object": "MESH:D005334"}
{"subject": "CHEBI:17154", "predicate": "biolink:correlated_with", "object": "CHEBI:15940", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D010383_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009536", "original_object": "CHEBI:15940"}
{"subject": "CHEBI:17154", "predicate": "biolink:affects", "object": "REACT:R-HSA-181438", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D009536", "original_object": "REACT:R-HSA-181438"}
{"subject": "CHEBI:7566", "predicate": "biolink:produces", "object": "CHEBI:26523", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11820_MESH_D014355_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009547", "original_object": "CHEBI:26523"}
{"subject": "CHEBI:7596", "predicate": "biolink:produces", "object": "CHEBI:16480", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00325_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009599", "original_object": "CHEBI:16480"}
{"subject": "CHEBI:7660", "predicate": "biolink:produces", "object": "GO:0046930", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002179_1", "DB00646_MESH_D002180_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009761", "original_object": "UBERON:0008915"}
{"subject": "CHEBI:7660", "predicate": "biolink:causes", "object": "UMLS:C0023775", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002179_1", "DB00646_MESH_D002180_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009761", "original_object": "UMLS:C0023775"}
{"subject": "CL:0000062", "predicate": "biolink:affects", "object": "UMLS:C0538161", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11093_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D010006", "original_object": "MESH:D053244"}
{"object": "CHEBI:29032", "predicate": "biolink:has_part", "subject": "CHEBI:15346", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09357_MESH_D003963_1", "DB09357_MESH_D007418_1", "DB09357_MESH_D018589_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:D010205", "original_subject": "MESH:D003065"}
{"subject": "MONDO:0006496", "predicate": "biolink:regulates", "object": "NCBITaxon:6282", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00602_MESH_D009855_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D010243", "original_object": "NCBITaxon:6282"}
{"subject": "CHEBI:7959", "predicate": "biolink:capable_of", "object": "GO:0046911", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00859_MESH_D001172_2", "DB00859_MESH_D003555_2", "DB00859_MESH_D006527_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010396", "original_object": "GO:0046911"}
{"subject": "UNII:RIT82F58GK", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR22935", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01053_MESH_D004886_1", "DB01053_MESH_D011018_1", "DB01053_MESH_D012541_1", "DB01053_MESH_D013290_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D010401", "original_object": "PANTHER.FAMILY:PTHR22935"}
{"subject": "MONDO:0004247", "predicate": "biolink:located_in", "object": "UBERON:0000945", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00501_MESH_D013276_1", "DB00517_MESH_D013276_1", "DB00863_MESH_D013276_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010437", "original_object": "UBERON:0000945"}
{"subject": "CHEBI:71416", "predicate": "biolink:disrupts", "object": "UniProtKB:P35498", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01438_MESH_D053159_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010621", "original_object": "UniProtKB:P35498"}
{"subject": "UMLS:C0032015", "predicate": "biolink:manifestation_of", "object": "MONDO:0005090", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00623_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010907", "original_object": "MESH:D012559"}
{"subject": "CHEBI:17381", "predicate": "biolink:manifestation_of", "object": "MONDO:0008294", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03404_MESH_D017118_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011162", "original_object": "MESH:D017118"}
{"subject": "CHEBI:8346", "predicate": "biolink:regulates", "object": "MONDO:0005271", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06715_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D011193", "original_object": "HP:0012393"}
{"subject": "CHEBI:26333", "predicate": "biolink:occurs_in", "object": "UBERON:0000955", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08797_MESH_D005334_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011453", "original_object": "UBERON:0000955"}
{"subject": "CHEBI:16709", "predicate": "biolink:interacts_with", "object": "UniProtKB:O00764", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00165_MESH_D026681_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011736", "original_object": "UniProtKB:O00764"}
{"subject": "UBERON:0001866", "predicate": "biolink:treats", "object": "MONDO:0011438", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00655_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D012629", "original_object": "MESH:D000152"}
{"subject": "CHEBI:9142", "predicate": "biolink:disrupts", "object": "GO:0009274", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05245_MESH_D012883_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D012837", "original_object": "GO:0009274"}
{"subject": "HP:0002487", "predicate": "biolink:affects", "object": "HP:0032155", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00771_MESH_D043183_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D013035", "original_object": "HP:0032155"}
{"object": "UMLS:C0038585", "predicate": "biolink:has_participant", "subject": "UMLS:C0600467", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00405_MESH_D012223_1", "DB01114_MESH_D012223_1", "DB04837_MESH_D012223_1", "DB06691_MESH_D012223_1", "DB08799_MESH_D012223_2", "DB09488_MESH_D012223_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:D013373", "original_subject": "MESH:D020078"}
{"subject": "CHEBI:60311", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0004425", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00763_MESH_D006980_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D013963", "original_object": "MESH:D006980"}
{"subject": "CHEBI:39501", "predicate": "biolink:directly_physically_interacts_with", "object": "UMLS:C1517336", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014266", "original_object": "UMLS:C1517336"}
{"subject": "CHEBI:17855", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:39026", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08949_MESH_D006937_1", "DB08949_MESH_D006950_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014280", "original_object": "MESH:D008077"}
{"subject": "CHEBI:28001", "predicate": "biolink:disrupts", "object": "UMLS:C0031164", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00512_MESH_D000071074_1", "DB00512_MESH_D004697_1", "DB00512_MESH_D004761_1", "DB00512_MESH_D011023_1", "DB00512_MESH_D013203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014640", "original_object": "UMLS:C0031164"}
{"subject": "UMLS:C0042404", "predicate": "biolink:regulates", "object": "GO:0001659", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00286_MESH_D019584_1", "DB01395_MESH_D019584_1", "DB04575_MESH_D019584_1", "DB06401_MESH_D019584_1", "DB06710_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D014666", "original_object": "GO:0001659"}
{"subject": "MESH:D015021", "predicate": "biolink:produces", "object": "UMLS:C2607955", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D015021", "original_object": "UMLS:C2607955"}
{"subject": "UMLS:C0000360", "predicate": "biolink:regulates", "object": "GO:0019933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00277_MESH_D000080445_1", "DB00277_MESH_D001249_1", "DB00277_MESH_D001986_1", "DB00277_MESH_D001991_1", "DB00277_MESH_D011656_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D015106", "original_object": "GO:0019933"}
{"subject": "UMLS:C0079189", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB07615_MESH_D003876_2", "DB07615_MESH_D065631_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D016207", "original_object": "GO:0006954"}
{"subject": "CHEBI:6504", "predicate": "biolink:regulates", "object": "GO:0004972", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01356_MESH_D001171_1", "DB01356_MESH_D001172_1", "DB01356_MESH_D001714_1", "DB01356_MESH_D004412_1", "DB01356_MESH_D010003_1", "DB01356_MESH_D010146_1", "DB01356_MESH_D020773_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D016651", "original_object": "GO:0004972"}
{"subject": "CHEBI:6504", "predicate": "biolink:causes", "object": "HP:0001945", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01356_MESH_D005334_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D016651", "original_object": "MESH:D005334"}
{"subject": "UMLS:C0085295", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR24169", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11750_MESH_D003876_2", "DB11750_MESH_D003877_2", "DB11750_MESH_D012536_2", "DB11750_MESH_D012628_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D016753", "original_object": "PANTHER.FAMILY:PTHR24169"}
{"subject": "UMLS:C0071253", "predicate": "biolink:positively_correlated_with", "object": "GO:0048008", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12323_MESH_D015464_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D017479", "original_object": "GO:0048008"}
{"object": "CHEBI:16359", "predicate": "biolink:produces", "subject": "UBERON:0002423", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02659_MESH_D001660_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:D019826", "original_subject": "UBERON:0002423"}
{"object": "CHEBI:16359", "predicate": "biolink:produces", "subject": "UniProtKB:Q02318", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02659_MESH_D019294_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:D019826", "original_subject": "UniProtKB:Q02318"}
{"subject": "MESH:D044062", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB07615_MESH_D003876_2", "DB07615_MESH_D065631_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D044062", "original_object": "GO:0006954"}
{"subject": "UMLS:C0070099", "predicate": "biolink:contributes_to", "object": "MONDO:0043455", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00443_MESH_C562390_1", "DB00620_MESH_C562390_1", "DB00635_MESH_C562390_1", "DB00741_MESH_C562390_1", "DB00860_MESH_C562390_1", "DB00959_MESH_C562390_1", "DB01380_MESH_C562390_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D044162", "original_object": "MESH:C562390"}
{"subject": "UMLS:C0010749", "predicate": "biolink:in_taxon", "object": "NCBITaxon:5658", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09031_MESH_D007897_1", "DB09031_MESH_D016773_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D045304", "original_object": "NCBITaxon:5658"}
{"subject": "NCBIGene:707236", "predicate": "biolink:positively_correlated_with", "object": "HP:0025249", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00799_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGene:707236", "original_object": "HP:0025249"}
{"subject": "NCBITaxon:100816", "predicate": "biolink:causes", "object": "MONDO:0016823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01263_MESH_D008271_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:100816", "original_object": "MESH:D008271"}
{"subject": "NCBITaxon:1280", "predicate": "biolink:occurs_in", "object": "MONDO:0024313", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01211_MESH_D013203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1280", "original_object": "MESH:D013203"}
{"subject": "NCBITaxon:1313", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0006913", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00760_MESH_D008586_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1313", "original_object": "MESH:D008586"}
{"subject": "NCBITaxon:2", "predicate": "biolink:produces", "object": "CHEBI:16134", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01220_MESH_D006501_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:2", "original_object": "MESH:D000641"}
{"subject": "NCBITaxon:2", "predicate": "biolink:causes", "object": "HP:0030049", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00916_MESH_D001922_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:2", "original_object": "MESH:D001922"}
{"subject": "NCBITaxon:2", "predicate": "biolink:positively_correlated_with", "object": "HP:0200042", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00359_MESH_D012883_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:2", "original_object": "MESH:D012883"}
{"subject": "NCBITaxon:562", "predicate": "biolink:regulates", "object": "GO:0097272", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00994_MESH_D006501_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:562", "original_object": "GO:0097272"}
{"subject": "PANTHER.FAMILY:PTHR11716", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:25029", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D016410_1", "DB00240_MESH_D016460_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR11716", "original_object": "CHEBI:25029"}
{"subject": "PANTHER.FAMILY:PTHR18966", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:18237", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00463_MESH_D004827_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR18966", "original_object": "MESH:D018698"}
{"subject": "PANTHER.FAMILY:PTHR22935", "predicate": "biolink:actively_involved_in", "object": "GO:0009273", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00833_MESH_D010612_1", "DB00833_MESH_D011014_1", "DB00833_MESH_D011018_1", "DB00833_MESH_D012141_1", "DB00833_MESH_D013203_1", "DB00833_MESH_D013290_1", "DB00833_MESH_D014069_1", "DB00833_MESH_D014552_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR22935", "original_object": "GO:0009273"}
{"subject": "PANTHER.FAMILY:PTHR22935", "predicate": "biolink:preventative_for_condition", "object": "GO:0018104", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01333_MESH_D012141_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR22935", "original_object": "GO:0018104"}
{"subject": "PANTHER.FAMILY:PTHR46448", "predicate": "biolink:positively_correlated_with", "object": "UniProtKB:P04049", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00398_MESH_D002292_1", "DB00398_MESH_D006528_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR46448", "original_object": "UniProtKB:P04049"}
{"subject": "PANTHER.FAMILY:PTHR46987", "predicate": "biolink:correlated_with", "object": "HP:0000708", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00623_MESH_D011618_1", "DB00623_MESH_D012559_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR46987", "original_object": "HP:0000708"}
{"object": "REACT:R-HSA-1169410", "predicate": "biolink:has_part", "subject": "GO:0140374", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00008_MESH_D019698_1", "DB00008_MESH_D019698_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-HSA-1169410", "original_subject": "GO:0140374"}
{"subject": "REACT:R-HSA-1169410", "predicate": "biolink:disrupts", "object": "NCBITaxon:10407", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00105_MESH_D019694_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-1169410", "original_object": "NCBITaxon:10407"}
{"subject": "REACT:R-HSA-1296059", "predicate": "biolink:correlated_with", "object": "HP:0002791", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01183_MESH_D009293_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-1296059", "original_object": "HP:0002791"}
{"subject": "REACT:R-HSA-1592389", "predicate": "biolink:regulates", "object": "HP:0100773", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00026_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "REACT:R-HSA-1592389", "original_object": "HP:0100773"}
{"subject": "GO:0016125", "predicate": "biolink:disrupts", "object": "UMLS:C0025245", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D004827_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-211976", "original_object": "UMLS:C0025245"}
{"subject": "REACT:R-HSA-2162123", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0005277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D008881_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-2162123", "original_object": "MESH:D008881"}
{"subject": "REACT:R-HSA-2162123", "predicate": "biolink:has_output", "object": "CHEBI:15627", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00945_MESH_D013927_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-2162123", "original_object": "MESH:D013928"}
{"subject": "REACT:R-HSA-2162123", "predicate": "biolink:occurs_in", "object": "UBERON:0000955", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00316_MESH_D005334_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-2162123", "original_object": "UBERON:0000955"}
{"subject": "REACT:R-HSA-390651", "predicate": "biolink:correlated_with", "object": "MONDO:0005090", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00875_MESH_D012559_1", "DB06216_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-390651", "original_object": "MESH:D012559"}
{"subject": "REACT:R-HSA-390651", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005090", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13676_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-390651", "original_object": "MESH:D012559"}
{"subject": "REACT:R-HSA-556833", "predicate": "biolink:disrupts", "object": "UMLS:C0025245", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D004827_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-556833", "original_object": "UMLS:C0025245"}
{"subject": "REACT:R-HSA-70171", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5833", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00468_MESH_D016778_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-70171", "original_object": "NCBITaxon:5833"}
{"subject": "GO:0006068", "predicate": "biolink:has_output", "object": "CHEBI:30751", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01213_MESH_D000138_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-71384", "original_object": "MESH:C030544"}
{"object": "UBERON:0000004", "predicate": "biolink:affects", "subject": "MONDO:0005324", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01114_MESH_D006255_1", "DB06691_MESH_D006255_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0000004", "original_subject": "MESH:D006255"}
{"object": "UBERON:0000004", "predicate": "biolink:affects", "subject": "UBERON:0001645", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00341_MESH_D012912_1", "DB00434_MESH_D012912_1", "DB00434_MESH_D012912_2", "DB00637_MESH_D012912_1", "DB00719_MESH_D012912_1", "DB00950_MESH_D012912_1", "DB01114_MESH_D012912_1", "DB01176_MESH_D012912_1", "DB06691_MESH_D012912_1", "DB08799_MESH_D012912_1", "DB09488_MESH_D012912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0000004", "original_subject": "UBERON:0001645"}
{"subject": "UBERON:0000007", "predicate": "biolink:produces", "object": "UMLS:C0018061", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06785_MESH_D010062_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000007", "original_object": "UMLS:C0018061"}
{"subject": "UBERON:0000013", "predicate": "biolink:positively_correlated_with", "object": "GO:0045777", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09242_MESH_D000075222_1", "DB11738_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000013", "original_object": "GO:0045777"}
{"subject": "UBERON:0000013", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0018229", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00521_MESH_D006973_1", "DB08808_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000013", "original_object": "UBERON:0018229"}
{"object": "UBERON:0000054", "predicate": "biolink:has_participant", "subject": "GO:0016209", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00137_MESH_D000080343_2", "DB00137_MESH_D008268_2", "DB00137_MESH_D015352_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0000054", "original_subject": "GO:0016209"}
{"subject": "UBERON:0000176", "predicate": "biolink:causes", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00972_MESH_D006255_1", "DB00972_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000176", "original_object": "HP:0000989"}
{"subject": "UBERON:0000178", "predicate": "biolink:affects", "object": "CHEBI:17855", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09568_MESH_D015228_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "degradation", "original_subject": "UBERON:0000178", "original_object": "MESH:D014280"}
{"subject": "UBERON:0000381", "predicate": "biolink:regulates", "object": "GO:0060073", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00424_MESH_D053159_1", "DB00458_MESH_D053206_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0000381", "original_object": "GO:0060073"}
{"subject": "UBERON:0000410", "predicate": "biolink:correlated_with", "object": "GO:0070254", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06767_MESH_D003139_1", "DB06767_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000410", "original_object": "GO:0070254"}
{"subject": "UBERON:0000451", "predicate": "biolink:regulates", "object": "HP:0000708", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12710_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000451", "original_object": "HP:0000708"}
{"subject": "UBERON:0000912", "predicate": "biolink:positively_correlated_with", "object": "HP:0031417", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09154_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000912", "original_object": "HP:0031417"}
{"subject": "UBERON:0000955", "predicate": "biolink:affects", "object": "CHEBI:15514", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D008881_1", "DB00313_MESH_D008881_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "UBERON:0000955", "original_object": "MESH:C026563"}
{"subject": "UBERON:0000955", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005027", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00832_MESH_D004827_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000955", "original_object": "MESH:D004827"}
{"subject": "UBERON:0000995", "predicate": "biolink:affects", "object": "GO:0070471", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01253_MESH_D006473_1", "DB01282_MESH_D006473_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "UBERON:0000995", "original_object": "GO:0070471"}
{"subject": "UBERON:0001003", "predicate": "biolink:positively_correlated_with", "object": "HP:0040189", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01243_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001003", "original_object": "HP:0040189"}
{"subject": "UBERON:0001013", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0012104", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09046_MESH_C562448_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001013", "original_object": "MESH:C562448"}
{"subject": "UBERON:0001017", "predicate": "biolink:preventative_for_condition", "object": "HP:0008760", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00477_MESH_D011618_1", "DB00477_MESH_D012559_1", "DB00477_MESH_D019958_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001017", "original_object": "HP:0008760"}
{"subject": "UBERON:0001017", "predicate": "biolink:correlated_with", "object": "PANTHER.FAMILY:PTHR46987", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00623_MESH_D011618_1", "DB00623_MESH_D012559_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001017", "original_object": "PANTHER.FAMILY:PTHR46987"}
{"subject": "UBERON:0001133", "predicate": "biolink:affects", "object": "MONDO:0000745", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00326_MESH_D006323_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UBERON:0001133", "original_object": "MESH:D006323"}
{"object": "UBERON:0001133", "predicate": "biolink:affects", "subject": "HP:0002153", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00258_MESH_D006947_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0001133", "original_subject": "MESH:D006947"}
{"subject": "UBERON:0001133", "predicate": "biolink:affects", "object": "HP:0002153", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00326_MESH_D006947_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UBERON:0001133", "original_object": "MESH:D006947"}
{"object": "UBERON:0001135", "predicate": "biolink:located_in", "subject": "UBERON:0000995", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01253_MESH_D006473_1", "DB01282_MESH_D006473_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0001135", "original_subject": "UBERON:0000995"}
{"subject": "UBERON:0001155", "predicate": "biolink:correlated_with", "object": "MONDO:0002203", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09020_MESH_D003248_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001155", "original_object": "MESH:D003248"}
{"subject": "UBERON:0001202", "predicate": "biolink:regulates", "object": "MONDO:0007186", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00604_MESH_D005764_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0001202", "original_object": "MESH:D005764"}
{"subject": "UBERON:0001295", "predicate": "biolink:correlated_with", "object": "HP:0030126", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00396_MESH_D008796_1", "DB00603_MESH_D008796_1", "DB00717_MESH_D008595_2", "DB00717_MESH_D008796_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001295", "original_object": "HP:0030126"}
{"object": "UBERON:0001629", "predicate": "biolink:has_participant", "subject": "GO:0003035", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00561_MESH_D012131_1", "DB01430_MESH_D029424_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0001629", "original_subject": "GO:0003035"}
{"object": "UBERON:0001645", "predicate": "biolink:has_participant", "subject": "GO:0019233", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00918_MESH_D008881_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0001645", "original_subject": "GO:0019233"}
{"subject": "UBERON:0001645", "predicate": "biolink:contributes_to", "object": "HP:0025095", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00341_MESH_D012912_1", "DB00434_MESH_D012912_1", "DB00434_MESH_D012912_2", "DB00637_MESH_D012912_1", "DB00719_MESH_D012912_1", "DB00950_MESH_D012912_1", "DB01114_MESH_D012912_1", "DB01176_MESH_D012912_1", "DB06691_MESH_D012912_1", "DB08799_MESH_D012912_1", "DB09488_MESH_D012912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001645", "original_object": "MESH:D012912"}
{"object": "UBERON:0001796", "predicate": "biolink:has_participant", "subject": "HP:0007906", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00964_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0001796", "original_subject": "HP:0007906"}
{"subject": "UBERON:0001796", "predicate": "biolink:regulates", "object": "HP:0007906", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01210_MESH_D009798_3", "DB01210_MESH_D009798_4", "DB06826_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0001796", "original_object": "HP:0007906"}
{"subject": "UBERON:0001796", "predicate": "biolink:regulates", "object": "MONDO:0006875", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06826_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0001796", "original_object": "MESH:D009798"}
{"object": "UBERON:0001866", "predicate": "biolink:produces", "subject": "HP:0025249", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0001866", "original_subject": "HP:0025249"}
{"subject": "UBERON:0001870", "predicate": "biolink:contributes_to", "object": "GO:0051823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D001714_2", "DB00313_MESH_D001714_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001870", "original_object": "GO:0051823"}
{"subject": "UBERON:0001910", "predicate": "biolink:correlated_with", "object": "HP:0000746", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00850_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001910", "original_object": "HP:0000746"}
{"object": "UBERON:0001977", "predicate": "biolink:located_in", "subject": "MONDO:0001566", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00974_MESH_D006934_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0001977", "original_subject": "MESH:D006934"}
{"object": "UBERON:0002038", "predicate": "biolink:disrupts", "subject": "MONDO:0005180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00245_MESH_D010300_1", "DB00915_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0002038", "original_subject": "MESH:D010300"}
{"object": "UBERON:0002038", "predicate": "biolink:has_part", "subject": "UBERON:0014169", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00268_MESH_D010300_1", "DB00413_MESH_D010300_1", "DB00714_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0002038", "original_subject": "UBERON:0014169"}
{"object": "UBERON:0002038", "predicate": "biolink:has_participant", "subject": "UBERON:0014169", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01200_MESH_D010300_1", "DB01200_MESH_D010301_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0002038", "original_subject": "UBERON:0014169"}
{"subject": "UBERON:0002107", "predicate": "biolink:regulates", "object": "CHEBI:17347", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00655_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0002107", "original_object": "MESH:D013739"}
{"object": "UBERON:0002185", "predicate": "biolink:has_part", "subject": "UBERON:0002048", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09082_MESH_D011656_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0002185", "original_subject": "UBERON:0002048"}
{"subject": "UBERON:0002306", "predicate": "biolink:occurs_in", "object": "MONDO:0005709", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00462_MESH_D003139_1", "DB00747_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002306", "original_object": "MESH:D003139"}
{"subject": "UBERON:0002439", "predicate": "biolink:positively_correlated_with", "object": "GO:0050892", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08900_MESH_D012778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002439", "original_object": "GO:0050892"}
{"subject": "UBERON:0002439", "predicate": "biolink:regulates", "object": "UBERON:0004221", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00836_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0002439", "original_object": "UBERON:0004221"}
{"subject": "UBERON:0003956", "predicate": "biolink:negatively_correlated_with", "object": "HP:0007906", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00484_MESH_D005902_2", "DB01085_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003956", "original_object": "HP:0007906"}
{"subject": "UBERON:0005969", "predicate": "biolink:affects", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06826_MESH_D005902_1", "DB06826_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "UBERON:0005969", "original_object": "UBERON:0001796"}
{"subject": "UBERON:0005969", "predicate": "biolink:regulates", "object": "UBERON:0003956", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01085_MESH_D005902_1", "DB01085_MESH_D009798_1", "DB13165_MESH_D005901_1", "DB13165_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0005969", "original_object": "UBERON:0003956"}
{"subject": "UBERON:0008826", "predicate": "biolink:affects", "object": "GO:0043129", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06761_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UBERON:0008826", "original_object": "GO:0043129"}
{"subject": "GO:0046930", "predicate": "biolink:located_in", "object": "GO:0030445", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002179_1", "DB00646_MESH_D002180_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0008915", "original_object": "GO:0030445"}
{"object": "UBERON:0010061", "predicate": "biolink:affects", "subject": "MONDO:0005324", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00405_MESH_D006255_1", "DB09488_MESH_D006255_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0010061", "original_subject": "MESH:D006255"}
{"subject": "UBERON:0010210", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005068", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00266_MESH_D009203_1", "DB00946_MESH_D009203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010210", "original_object": "MESH:D009203"}
{"subject": "UBERON:0010210", "predicate": "biolink:predisposes_to_condition", "object": "HP:0001907", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00266_MESH_D013923_1", "DB00946_MESH_D013923_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010210", "original_object": "MESH:D013923"}
{"subject": "UBERON:0010427", "predicate": "biolink:correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01210_MESH_D005902_1", "DB01210_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010427", "original_object": "UBERON:0001796"}
{"subject": "UBERON:0025525", "predicate": "biolink:negatively_correlated_with", "object": "HP:0030895", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08890_MESH_D043183_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0025525", "original_object": "HP:0030895"}
{"object": "UBERON:0027221", "predicate": "biolink:has_participant", "subject": "MONDO:0002050", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00934_MESH_D003866_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0027221", "original_subject": "HP:0000716"}
{"subject": "UBERON:0035999", "predicate": "biolink:located_in", "object": "UBERON:0002038", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00268_MESH_D010300_1", "DB00413_MESH_D010300_1", "DB00714_MESH_D010300_1", "DB01200_MESH_D010300_1", "DB01200_MESH_D010301_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0035999", "original_object": "UBERON:0002038"}
{"subject": "UMLS:C0001471", "predicate": "biolink:regulates", "object": "HP:4000007", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00277_MESH_D000080445_1", "DB00277_MESH_D001249_1", "DB00277_MESH_D001986_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UMLS:C0001471", "original_object": "HP:4000007"}
{"object": "UMLS:C0001639", "predicate": "biolink:has_participant", "subject": "REACT:R-HSA-418594", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00484_MESH_D012393_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UMLS:C0001639", "original_subject": "REACT:R-HSA-418594"}
{"subject": "UMLS:C0018061", "predicate": "biolink:causes", "object": "UMLS:C0029967", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06785_MESH_D010062_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0018061", "original_object": "UMLS:C0029967"}
{"subject": "UMLS:C0023775", "predicate": "biolink:disrupts", "object": "GO:0006811", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002179_1", "DB00646_MESH_D002180_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0023775", "original_object": "GO:0006811"}
{"subject": "UMLS:C0026698", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0004822", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06151_MESH_D001987_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0026698", "original_object": "MESH:D001987"}
{"subject": "UMLS:C0031164", "predicate": "biolink:in_taxon", "object": "NCBITaxon:1280", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00512_MESH_D004697_1", "DB00512_MESH_D011023_1", "DB00512_MESH_D013203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0031164", "original_object": "NCBITaxon:1280"}
{"subject": "UMLS:C0042774", "predicate": "biolink:positively_correlated_with", "object": "UMLS:C0282629", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09102_MESH_D019698_1", "DB09296_MESH_D019698_1", "DB11613_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0042774", "original_object": "UMLS:C0282629"}
{"subject": "UMLS:C0079427", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0018874", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01262_MESH_D015470_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0079427", "original_object": "MESH:D015470"}
{"subject": "UMLS:C0162713", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:26519", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00855_MESH_D055623_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0162713", "original_object": "MESH:D005609"}
{"subject": "UMLS:C0282090", "predicate": "biolink:positively_correlated_with", "object": "GO:0030421", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00653_MESH_D003248_1", "DB09104_MESH_D003248_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0282090", "original_object": "GO:0030421"}
{"subject": "UMLS:C0282090", "predicate": "biolink:regulates", "object": "GO:0030421", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01377_MESH_D003248_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UMLS:C0282090", "original_object": "GO:0030421"}
{"subject": "UMLS:C0282090", "predicate": "biolink:negatively_correlated_with", "object": "HP:0012423", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00581_MESH_D003248_1", "DB04816_MESH_D003248_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0282090", "original_object": "HP:0012423"}
{"subject": "UMLS:C1517336", "predicate": "biolink:affects", "object": "UniProtKB:O14746", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UMLS:C1517336", "original_object": "UniProtKB:O14746"}
{"subject": "UMLS:C2607955", "predicate": "biolink:causes", "object": "GO:0008219", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C2607955", "original_object": "GO:0008219"}
{"object": "UniProtKB:A4WFD5", "predicate": "biolink:has_part", "subject": "GO:0015935", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00479_MESH_D004756_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:A4WFD5", "original_subject": "GO:0015935"}
{"subject": "UniProtKB:B0B3C9", "predicate": "biolink:capable_of", "object": "GO:0008236", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05521_MESH_D019698_1", "DB11575_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:B0B3C9", "original_object": "GO:0008236"}
{"object": "UniProtKB:B4DP61", "predicate": "biolink:disrupts", "subject": "MONDO:0001516", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13161_MESH_D009134_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:B4DP61", "original_subject": "MESH:D009134"}
{"object": "UniProtKB:O14773", "predicate": "biolink:has_participant", "subject": "GO:0034701", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13173_MESH_D009472_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:O14773", "original_subject": "GO:0034701"}
{"subject": "UniProtKB:O95838", "predicate": "biolink:located_in", "object": "CL:1001516", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08900_MESH_D012778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:O95838", "original_object": "CL:1001516"}
{"subject": "UniProtKB:O95838", "predicate": "biolink:located_in", "object": "UBERON:0002439", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08900_MESH_D012778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:O95838", "original_object": "UBERON:0002439"}
{"object": "UniProtKB:P00519", "predicate": "biolink:has_participant", "subject": "PR:000029194", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04868_MESH_D015466_1", "DB08901_MESH_D015464_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P00519", "original_subject": "PR:000029194"}
{"subject": "UniProtKB:P00797", "predicate": "biolink:regulates", "object": "CHEBI:147350", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09026_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P00797", "original_object": "PUBCHEM.COMPOUND:3081372"}
{"subject": "UniProtKB:P01308", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0002909", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01067_MESH_D006943_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P01308", "original_object": "MESH:D006943"}
{"object": "UniProtKB:P01584", "predicate": "biolink:produces", "subject": "CL:0000576", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01394_MESH_D006073_1", "DB01394_MESH_D010505_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P01584", "original_subject": "CL:0000576"}
{"subject": "UniProtKB:P02656", "predicate": "biolink:positively_correlated_with", "object": "MESH:D015243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04145_MESH_D006949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P02656", "original_object": "MESH:D015243"}
{"subject": "UniProtKB:P02766", "predicate": "biolink:enables", "object": "GO:0042802", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05352_MESH_D000686_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P02766", "original_object": "GO:0042802"}
{"subject": "UniProtKB:P03372", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:50114", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00882_MESH_D007247_1", "DB04938_MESH_D004414_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P03372", "original_object": "MESH:D004967"}
{"subject": "UniProtKB:P04062", "predicate": "biolink:regulates", "object": "CHEBI:36500", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00053_MESH_D005776_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P04062", "original_object": "MESH:D005963"}
{"subject": "UniProtKB:P04150", "predicate": "biolink:affects", "object": "HGNC.FAMILY:404", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D003876_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D009450_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D016410_1", "DB00240_MESH_D016460_1", "DB01234_MESH_C562390_1", "DB01234_MESH_D000744_1", "DB01234_MESH_D000799_1", "DB01234_MESH_D001172_1", "DB01234_MESH_D001249_1", "DB01234_MESH_D001607_1", "DB01234_MESH_D001929_1", "DB01234_MESH_D002051_1", "DB01234_MESH_D002062_1", "DB01234_MESH_D003233_1", "DB01234_MESH_D003320_1", "DB01234_MESH_D003424_1", "DB01234_MESH_D003873_1", "DB01234_MESH_D003874_1", "DB01234_MESH_D003876_1", "DB01234_MESH_D003877_1", "DB01234_MESH_D004892_1", "DB01234_MESH_D005076_1", "DB01234_MESH_D005128_1", "DB01234_MESH_D006689_1", "DB01234_MESH_D007500_1", "DB01234_MESH_D007627_1", "DB01234_MESH_D007634_1", "DB01234_MESH_D007819_1", "DB01234_MESH_D008179_1", "DB01234_MESH_D008180_1", "DB01234_MESH_D008224_1", "DB01234_MESH_D008228_1", "DB01234_MESH_D009101_1", "DB01234_MESH_D009103_1", "DB01234_MESH_D009140_1", "DB01234_MESH_D009182_1", "DB01234_MESH_D009404_1", "DB01234_MESH_D009450_1", "DB01234_MESH_D010032_1", "DB01234_MESH_D010392_1", "DB01234_MESH_D011538_1", "DB01234_MESH_D011565_1", "DB01234_MESH_D011657_1", "DB01234_MESH_D012214_1", "DB01234_MESH_D012393_1", "DB01234_MESH_D012507_1", "DB01234_MESH_D012628_1", "DB01234_MESH_D012713_1", "DB01234_MESH_D012871_1", "DB01234_MESH_D013167_1", "DB01234_MESH_D013716_1", "DB01234_MESH_D013717_2", "DB01234_MESH_D013966_1", "DB01234_MESH_D014235_1", "DB01234_MESH_D014391_1", "DB01234_MESH_D014605_1", "DB01234_MESH_D014606_1", "DB01234_MESH_D015210_1", "DB01234_MESH_D015212_1", "DB01234_MESH_D015535_1", "DB01234_MESH_D015863_1", "DB01234_MESH_D016403_1", "DB01234_MESH_D016410_1", "DB01234_MESH_D016460_1", "DB01234_MESH_D029503_1", "DB01234_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "UniProtKB:P04150", "original_object": "HGNC.FAMILY:404"}
{"subject": "UniProtKB:P05155", "predicate": "biolink:negatively_correlated_with", "object": "UMLS:C0022478", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06718_MESH_D054179_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P05155", "original_object": "MESH:D007610"}
{"subject": "UniProtKB:P06401", "predicate": "biolink:correlated_with", "object": "UMLS:C0042404", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P06401", "original_object": "MESH:D014666"}
{"object": "UniProtKB:P07437", "predicate": "biolink:has_part", "subject": "GO:1902850", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00541_MESH_D002051_1", "DB00541_MESH_D006689_1", "DB00541_MESH_D008224_1", "DB00541_MESH_D008228_1", "DB00541_MESH_D009396_1", "DB00541_MESH_D009447_1", "DB00541_MESH_D012208_1", "DB00541_MESH_D016403_1", "DB00570_MESH_C538636_2", "DB00570_MESH_D006689_2", "DB00570_MESH_D008228_2", "DB00570_MESH_D009182_2", "DB00570_MESH_D012514_2", "DB00570_MESH_D013736_2", "DB00570_MESH_D031901_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P07437", "original_subject": "GO:1902850"}
{"subject": "UniProtKB:P07550", "predicate": "biolink:causes", "object": "GO:0097366", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01364_MESH_D001991_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P07550", "original_object": "GO:0097366"}
{"subject": "UniProtKB:P07550", "predicate": "biolink:regulates", "object": "UBERON:0000013", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00521_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P07550", "original_object": "UBERON:0000013"}
{"subject": "UniProtKB:P07550", "predicate": "biolink:regulates", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01214_MESH_D005902_1", "DB01214_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P07550", "original_object": "UBERON:0001796"}
{"subject": "UniProtKB:P08235", "predicate": "biolink:positively_correlated_with", "object": "GO:0005890", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D065446_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08235", "original_object": "GO:0005890"}
{"subject": "UniProtKB:P08235", "predicate": "biolink:positively_correlated_with", "object": "HGNC.FAMILY:1203", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D065446_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08235", "original_object": "HGNC.FAMILY:1203"}
{"subject": "UniProtKB:P08908", "predicate": "biolink:correlated_with", "object": "CHEBI:28790", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12833_MESH_D002012_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08908", "original_object": "MESH:D012701"}
{"subject": "UniProtKB:P08913", "predicate": "biolink:correlated_with", "object": "GO:0061529", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09304_MESH_D003866_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08913", "original_object": "GO:0061529"}
{"subject": "UniProtKB:P08913", "predicate": "biolink:treats", "object": "MONDO:0005302", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01018_MESH_D001289_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08913", "original_object": "MESH:D001289"}
{"subject": "UniProtKB:P08913", "predicate": "biolink:correlated_with", "object": "MONDO:0002009", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06148_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08913", "original_object": "MESH:D003865"}
{"subject": "UniProtKB:P0A7J3", "predicate": "biolink:located_in", "object": "GO:0005840", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00954_MESH_D001991_1", "DB00954_MESH_D010612_1", "DB00954_MESH_D011014_1", "DB00954_MESH_D014069_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P0A7J3", "original_object": "GO:0005840"}
{"subject": "UniProtKB:P10276", "predicate": "biolink:negatively_correlated_with", "object": "NCBIGene:707236", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00799_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P10276", "original_object": "NCBIGene:707236"}
{"subject": "UniProtKB:P10276", "predicate": "biolink:negatively_correlated_with", "object": "REACT:R-HSA-181438", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00799_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P10276", "original_object": "REACT:R-HSA-181438"}
{"subject": "UniProtKB:P10636", "predicate": "biolink:contributes_to", "object": "HP:0002185", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08842_MESH_D000544_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P10636", "original_object": "HP:0002185"}
{"subject": "UniProtKB:P11388", "predicate": "biolink:occurs_in", "object": "CL:0000084", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01204_MESH_D020529_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P11388", "original_object": "CL:0000084"}
{"subject": "UniProtKB:P11473", "predicate": "biolink:in_complex_with", "object": "UniProtKB:P19793", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01436_MESH_D007011_1", "DB01436_MESH_D007011_2", "DB01436_MESH_D007011_3", "DB01436_MESH_D012080_1", "DB01436_MESH_D012080_2", "DB01436_MESH_D012080_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P11473", "original_object": "UniProtKB:P19793"}
{"subject": "UniProtKB:P11511", "predicate": "biolink:produces", "object": "CHEBI:50114", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00357_MESH_D001943_1", "DB01217_MESH_D001943_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P11511", "original_object": "MESH:D004967"}
{"object": "UniProtKB:P13423", "predicate": "biolink:produces", "subject": "NCBITaxon:1392", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DBDB08902_MESH_C571912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P13423", "original_subject": "NCBITaxon:1392"}
{"subject": "UniProtKB:P13945", "predicate": "biolink:positively_correlated_with", "object": "UniProtKB:P29474", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04861_MESH_D006973_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P13945", "original_object": "UniProtKB:P29474"}
{"object": "UniProtKB:P14416", "predicate": "biolink:causes", "subject": "GO:0014046", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01100_MESH_D005879_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P14416", "original_subject": "GO:0014046"}
{"subject": "UniProtKB:P14672", "predicate": "biolink:regulates", "object": "MONDO:0002909", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00331_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P14672", "original_object": "MESH:D006943"}
{"subject": "UniProtKB:P16444", "predicate": "biolink:disrupts", "object": "CHEBI:51799", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01597_MESH_D004697_1", "DB01597_MESH_D004716_1", "DB01597_MESH_D011018_1", "DB01597_MESH_D018410_1", "DB01597_MESH_D018784_1", "DB01597_MESH_D059413_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P16444", "original_object": "MESH:D015378"}
{"subject": "UniProtKB:P16473", "predicate": "biolink:expressed_in", "object": "UBERON:0002046", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00024_MESH_D013964_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P16473", "original_object": "UBERON:0002046"}
{"subject": "UniProtKB:P17252", "predicate": "biolink:contributes_to", "object": "GO:0051823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D001714_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P17252", "original_object": "GO:0051823"}
{"subject": "UniProtKB:P24530", "predicate": "biolink:capable_of", "object": "GO:0042310", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00559_MESH_D000081029_1", "DB00559_MESH_D006976_1", "DB00559_MESH_D012594_1", "DB06268_MESH_D000081029_1", "DB08932_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P24530", "original_object": "GO:0042310"}
{"subject": "UniProtKB:P25100", "predicate": "biolink:correlated_with", "object": "HP:0002071", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06144_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P25100", "original_object": "HP:0002071"}
{"subject": "UniProtKB:P28221", "predicate": "biolink:affects", "object": "UBERON:0001645", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00918_MESH_D008881_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:P28221", "original_object": "UBERON:0001645"}
{"subject": "UniProtKB:P35354", "predicate": "biolink:affects", "object": "GO:0001516", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB07615_MESH_D003876_2", "DB07615_MESH_D065631_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:P35354", "original_object": "GO:0001516"}
{"subject": "UniProtKB:P35367", "predicate": "biolink:has_phenotype", "object": "HP:0000969", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00342_MESH_D017449_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P35367", "original_object": "HP:0000969"}
{"subject": "UniProtKB:P37231", "predicate": "biolink:directly_physically_interacts_with", "object": "HGNC.FAMILY:2086", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P37231", "original_object": "HGNC.FAMILY:2086"}
{"subject": "UniProtKB:P43115", "predicate": "biolink:causes", "object": "HP:0012531", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00814_MESH_D010146_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P43115", "original_object": "MESH:D010146"}
{"subject": "UniProtKB:Q72547", "predicate": "biolink:expressed_in", "object": "GO:0039693", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00495_MESH_D015658_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q72547", "original_object": "GO:0039693"}
{"subject": "UniProtKB:Q7L0J3", "predicate": "biolink:affects", "object": "GO:0098982", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01202_MESH_D004828_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:Q7L0J3", "original_object": "GO:0098982"}
{"object": "UniProtKB:Q8I3Z5", "predicate": "biolink:has_part", "subject": "NCBITaxon:5833", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13132_MESH_D016778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:Q8I3Z5", "original_subject": "NCBITaxon:5833"}
{"subject": "UniProtKB:Q8NER1", "predicate": "biolink:regulates", "object": "CL:0000197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00405_MESH_D011537_1", "DB00434_MESH_D011537_1", "DB00557_MESH_D011537_1", "DB01084_MESH_D011537_1", "DB01114_MESH_D011537_1", "DB06691_MESH_D011537_1", "DB08799_MESH_D011537_1", "DB09555_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:Q8NER1", "original_object": "CL:0000197"}
{"subject": "UniProtKB:Q9HB55", "predicate": "biolink:affects", "object": "CHEBI:31243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09065_MESH_D015658_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "UniProtKB:Q9HB55", "original_object": "MESH:D000069446"}
{"subject": "UniProtKB:Q9Y2I1", "predicate": "biolink:affects", "object": "UBERON:0000013", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09242_MESH_D000075222_1", "DB11738_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:Q9Y2I1", "original_object": "UBERON:0000013"}
{"subject": "GO:0003843", "predicate": "biolink:target_for", "object": "MONDO:0044070", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00520_MESH_D058387_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0003843", "original_object": "MESH:D058387"}
{"subject": "HGNC.FAMILY:1109", "predicate": "biolink:target_for", "object": "MONDO:0011438", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09096_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:1109", "original_object": "MESH:D000152"}
{"subject": "HGNC.FAMILY:1203", "predicate": "biolink:target_for", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00645_MESH_D011537_1", "DB09085_MESH_D011537_1", "DB09345_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:1203", "original_object": "MESH:D011537"}
{"subject": "UMLS:C0066924", "predicate": "biolink:target_for", "object": "MONDO:0004247", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C047874", "original_object": "MESH:D010437"}
{"subject": "UMLS:C0016016", "predicate": "biolink:target_for", "object": "HP:0000132", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00302_MESH_D008595_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005341", "original_object": "MESH:D008595"}
{"subject": "MESH:D054680", "predicate": "biolink:target_for", "object": "MONDO:0001249", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09093_MESH_D014141_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D054680", "original_object": "MESH:D014141"}
{"subject": "UniProtKB:P30968", "predicate": "biolink:target_for", "object": "UMLS:C0029967", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06785_MESH_D010062_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P30968", "original_object": "UMLS:C0029967"}