{
    "nodes": {
        "biolink:MolecularMixture": {
            "id_prefixes": [
                "CHEBI",
                "UNII",
                "PUBCHEM.COMPOUND"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:Protein": {
            "id_prefixes": [
                "UniProtKB",
                "UMLS",
                "PR"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:taxon",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "taxon"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:Disease": {
            "id_prefixes": [
                "MONDO",
                "OMIM",
                "EFO",
                "DOID",
                "UMLS",
                "MESH"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:BiologicalProcess": {
            "id_prefixes": [
                "GO",
                "UMLS"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:SmallMolecule": {
            "id_prefixes": [
                "CHEBI",
                "UNII",
                "PUBCHEM.COMPOUND"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:PhenotypicFeature": {
            "id_prefixes": [
                "EFO",
                "HP",
                "NCIT",
                "MESH"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:Pathway": {
            "id_prefixes": [
                "REACT",
                "GO"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:GrossAnatomicalStructure": {
            "id_prefixes": [
                "UBERON"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:MolecularActivity": {
            "id_prefixes": [
                "GO",
                "UMLS"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:OrganismTaxon": {
            "id_prefixes": [
                "NCBITaxon"
            ],
            "attributes": [
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:ChemicalEntity": {
            "id_prefixes": [
                "CHEBI",
                "UNII",
                "MESH"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:CellularComponent": {
            "id_prefixes": [
                "GO",
                "MESH"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:GeneFamily": {
            "id_prefixes": [
                "HGNC.FAMILY",
                "PANTHER.FAMILY"
            ],
            "attributes": [
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:Cell": {
            "id_prefixes": [
                "CL",
                "UMLS"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:Procedure": {
            "id_prefixes": [
                "UMLS"
            ],
            "attributes": [
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:AnatomicalEntity": {
            "id_prefixes": [
                "MESH",
                "UBERON",
                "UMLS"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:information_content",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "information_content"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:Gene": {
            "id_prefixes": [
                "UMLS",
                "NCBIGene"
            ],
            "attributes": [
                {
                    "attribute_type_id": "dct:description",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "description"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:taxon",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "taxon"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:Phenomenon": {
            "id_prefixes": [
                "UMLS"
            ],
            "attributes": [
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:NucleicAcidEntity": {
            "id_prefixes": [
                "UMLS"
            ],
            "attributes": [
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        },
        "biolink:Drug": {
            "id_prefixes": [
                "UMLS"
            ],
            "attributes": [
                {
                    "attribute_type_id": "biolink:same_as",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "equivalent_identifiers"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ]
        }
    },
    "edges": [
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:produces",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:interacts_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:physically_interacts_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:has_metabolite",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "stability",
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:similar_to",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:disrupts",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:causes",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:contraindicated_in",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:treats",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:occurs_in",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:contributes_to",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:occurs_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:located_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:produces",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:has_part",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:coexists_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:subclass_of",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:has_active_ingredient",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:has_metabolite",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance",
                        "uptake"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:precedes",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:disrupts",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:located_in",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance",
                        "transport"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:subclass_of",
            "object": "biolink:Drug",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:predisposes_to_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:causes",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:manifestation_of",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:contraindicated_in",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:treats",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:occurs_in",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:ameliorates_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:contributes_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:capable_of",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:causes",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:ameliorates_condition",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:contributes_to",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:disrupts",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:in_taxon",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:occurs_in",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:disrupts",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:produces",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:coexists_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:located_in",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:subclass_of",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:has_metabolite",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance",
                        "degradation"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:disrupts",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:GeneFamily",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:disrupts",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:produces",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:located_in",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:contributes_to",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:disrupts",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:causes",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:contributes_to",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:capable_of",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:produces",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:regulates",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:located_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:occurs_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:disrupts",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:produces",
            "object": "biolink:MolecularMixture",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:derives_from",
            "object": "biolink:MolecularMixture",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:NucleicAcidEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:SmallMolecule",
            "predicate": "biolink:disrupts",
            "object": "biolink:Phenomenon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:has_participant",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:affects",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:MolecularMixture",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Cell",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Cell",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:located_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:has_participant",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:has_part",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:related_to",
            "object": "biolink:BiologicalProcess",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:contributes_to",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Pathway",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:manifestation_of",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:causes",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:treats",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:subclass_of",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:affects",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:contributes_to",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:precedes",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:manifestation_of",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:predisposes_to_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:causes",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:treats",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:occurs_in",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:contributes_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:produces",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:has_participant",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:located_in",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:affects",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:located_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:affects",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:in_taxon",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:OrganismTaxon",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Gene",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:PhenotypicFeature",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Drug",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:produces",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_output",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance",
                        "degradation"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:disrupts",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:produces",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:located_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_output",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:precedes",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:disrupts",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:actively_involved_in",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_part",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:related_to",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:contributes_to",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:precedes",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:capable_of",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:disrupts",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:predisposes_to_condition",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:causes",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:manifestation_of",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_phenotype",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:treats",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:related_to",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:ameliorates_condition",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:contributes_to",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:precedes",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:in_taxon",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:disrupts",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:produces",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:causes",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_part",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:disrupts",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:located_in",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_output",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:contributes_to",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:disrupts",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:predisposes_to_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:manifestation_of",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:causes",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:treats",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:related_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:precedes",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:contributes_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_phenotype",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:located_in",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_output",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_part",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:regulates",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:has_participant",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:located_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Gene",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:affects",
            "object": "biolink:MolecularMixture",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Phenomenon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:BiologicalProcess",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Drug",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:in_taxon",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:disrupts",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:produces",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:coexists_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:derives_from",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:has_metabolite",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:disrupts",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:located_in",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:occurs_in",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:disrupts",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:manifestation_of",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:predisposes_to_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:causes",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:treats",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:contributes_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:ameliorates_condition",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:contributes_to",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:disrupts",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:ameliorates_condition",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:capable_of",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:has_part",
            "object": "biolink:MolecularMixture",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:derives_from",
            "object": "biolink:MolecularMixture",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "stability",
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:disrupts",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:has_metabolite",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:subclass_of",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:capable_of",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:disrupts",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:produces",
            "object": "biolink:Phenomenon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:ChemicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Drug",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:has_participant",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:MolecularMixture",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:MolecularMixture",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Cell",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:has_participant",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:located_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Cell",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:affects",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Cell",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:disrupts",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:causes",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:related_to",
            "object": "biolink:BiologicalProcess",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:affects",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:disrupts",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Pathway",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:disrupts",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:manifestation_of",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:predisposes_to_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:causes",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:occurs_in",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:subclass_of",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:ameliorates_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:contributes_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:manifestation_of",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:predisposes_to_condition",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:subclass_of",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:contributes_to",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:in_taxon",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:regulates",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:occurs_in",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:OrganismTaxon",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:has_participant",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:disrupts",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:has_participant",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:located_in",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:affects",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:disrupts",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:located_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:affects",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Drug",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Disease",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Gene",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:has_participant",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:has_output",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:affects",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:causes",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:contributes_to",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:regulates",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:predisposes_to_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:treats",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:regulates",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:treats",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:regulates",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:has_participant",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:has_participant",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:affects",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:disrupts",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:has_participant",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:regulates",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:affects",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:regulates",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:occurs_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:located_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:in_taxon",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:occurs_in",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:disrupts",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:has_participant",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Pathway",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:has_part",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:target_for",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:in_taxon",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:occurs_in",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:located_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:has_part",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:regulates",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:located_in",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:has_participant",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:has_part",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:CellularComponent",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "degradation"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:has_part",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:contributes_to",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:predisposes_to_condition",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:causes",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:contributes_to",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:predisposes_to_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:treats",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:occurs_in",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:contributes_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:affects",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:regulates",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:located_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:has_participant",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:has_part",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:AnatomicalEntity",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:regulates",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:contraindicated_in",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:treats",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:causes",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:regulates",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:regulates",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:disrupts",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:affects",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:capable_of",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:produces",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:derives_from",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:has_metabolite",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:affects",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:disrupts",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:affects",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:subclass_of",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:regulates",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:affects",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:regulates",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:regulates",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:affects",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:regulates",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:interacts_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:affects",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:disrupts",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:affects",
            "object": "biolink:MolecularMixture",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularMixture",
            "predicate": "biolink:subclass_of",
            "object": "biolink:Drug",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:manifestation_of",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:causes",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:treats",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:contributes_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:causes",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:enables",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:contributes_to",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:capable_of",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:contributes_to",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:regulates",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:affects",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:located_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:produces",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Cell",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance",
                        "expression"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:produces",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:expressed_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:located_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:occurs_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:in_complex_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:has_participant",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "stability",
                        "abundance",
                        "degradation"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:disrupts",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:expressed_in",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:causes",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:ameliorates_condition",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:affects",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:contributes_to",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:capable_of",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:produces",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:ChemicalEntity",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:has_metabolite",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:affects",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:disrupts",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:produces",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:interacts_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:physically_interacts_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:has_part",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:affects",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance",
                        "degradation",
                        "expression"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:similar_to",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:disrupts",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:enables",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:has_part",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:capable_of",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:manifestation_of",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:causes",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:treats",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:contributes_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:target_for",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:located_in",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:affects",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:disrupts",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:causes",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:contributes_to",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:has_phenotype",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:target_for",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:affects",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:expressed_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:located_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:in_taxon",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:MolecularMixture",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:chemically_similar_to",
            "object": "biolink:MolecularMixture",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:MolecularMixture",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:affects",
            "object": "biolink:MolecularMixture",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:disrupts",
            "object": "biolink:MolecularMixture",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:affects",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:causes",
            "object": "biolink:Procedure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:target_for",
            "object": "biolink:Procedure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:affects",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:regulates",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:located_in",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Protein",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Gene",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:causes",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:has_participant",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:precedes",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:disrupts",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:in_taxon",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:occurs_in",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:has_participant",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:affects",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:produces",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:regulates",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:affects",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance",
                        "transport"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:disrupts",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:regulates",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:contributes_to",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:regulates",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:has_participant",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:affects",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:regulates",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:located_in",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:has_participant",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:regulates",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:regulates",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:affects",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:regulates",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:treats",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:contributes_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:target_for",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:has_participant",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:located_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:MolecularActivity",
            "predicate": "biolink:has_participant",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:causes",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:has_part",
            "object": "biolink:CellularComponent",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:produces",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:has_part",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:occurs_in",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:causes",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:produces",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:OrganismTaxon",
            "predicate": "biolink:causes",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Gene",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Gene",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Gene",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Gene",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:actively_involved_in",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:affects",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:contributes_to",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:target_for",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:regulates",
            "object": "biolink:MolecularActivity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:affects",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased",
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity",
                        "abundance",
                        "transport"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:correlated_with",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:regulates",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:treats",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:target_for",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:regulates",
            "object": "biolink:Pathway",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:Protein",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:located_in",
            "object": "biolink:Cell",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:regulates",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:MolecularMixture",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GeneFamily",
            "predicate": "biolink:correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:affects",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "increased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:interacts_with",
            "object": "biolink:MolecularMixture",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:produces",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:regulates",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:located_in",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:affects",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance",
                        "synthesis"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:correlated_with",
            "object": "biolink:AnatomicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:produces",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:affects",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "abundance"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:regulates",
            "object": "biolink:SmallMolecule",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:produces",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:has_part",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:located_in",
            "object": "biolink:GrossAnatomicalStructure",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:regulates",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:preventative_for_condition",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:affects",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:regulates",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:affects",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:correlated_with",
            "object": "biolink:GeneFamily",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:NucleicAcidEntity",
            "predicate": "biolink:directly_physically_interacts_with",
            "object": "biolink:SmallMolecule",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:NucleicAcidEntity",
            "predicate": "biolink:affects",
            "object": "biolink:Protein",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "qualified_predicate",
                    "applicable_values": [
                        "biolink:causes"
                    ]
                },
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "decreased"
                    ]
                },
                {
                    "qualifier_type_id": "object_aspect_qualifier",
                    "applicable_values": [
                        "activity"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Drug",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:Disease",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Drug",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:ChemicalEntity",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Drug",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Drug",
            "predicate": "biolink:regulates",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": [
                {
                    "qualifier_type_id": "object_direction_qualifier",
                    "applicable_values": [
                        "upregulates"
                    ]
                }
            ]
        },
        {
            "subject": "biolink:Drug",
            "predicate": "biolink:negatively_correlated_with",
            "object": "biolink:PhenotypicFeature",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Phenomenon",
            "predicate": "biolink:in_taxon",
            "object": "biolink:OrganismTaxon",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        },
        {
            "subject": "biolink:Phenomenon",
            "predicate": "biolink:positively_correlated_with",
            "object": "biolink:BiologicalProcess",
            "attributes": [],
            "qualifiers": []
        },
        {
            "subject": "biolink:Phenomenon",
            "predicate": "biolink:causes",
            "object": "biolink:BiologicalProcess",
            "attributes": [
                {
                    "attribute_type_id": "biolink:agent_type",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "agent_type"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_subject",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_subject"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:knowledge_level",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "knowledge_level"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:Attribute",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "drugmechdb_path_id"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                },
                {
                    "attribute_type_id": "biolink:original_object",
                    "attribute_source": null,
                    "original_attribute_names": [
                        "original_object"
                    ],
                    "constraint_use": false,
                    "constraint_name": null
                }
            ],
            "qualifiers": []
        }
    ]
}