{ "@context": { "@vocab": "https://schema.org/", "biolink": "https://w3id.org/biolink/" }, "@type": "Dataset", "@id": "https://robokop.renci.org/graphs/PHAROS/1.0.1/schema.json", "name": "A ROBOKOP Knowledge Graph based on Pharos Schema", "description": "Schema describing the nodes, edges, and attributes in the A ROBOKOP Knowledge Graph based on Pharos knowledge graph", "encodingFormat": "application/ld+json", "isPartOf": { "@type": "Dataset", "@id": "https://robokop.renci.org/graphs/PHAROS/1.0.1/", "name": "A ROBOKOP Knowledge Graph based on Pharos" }, "schema": { "nodes": [ { "category": [ "biolink:Disease" ], "count": 9940, "id_prefixes": { "MONDO": 8354, "UMLS": 1327, "OMIM": 123, "DOID": 55, "MESH": 38, "orphanet": 37, "EFO": 6 }, "attributes": { "name": 9940, "equivalent_identifiers": 9940, "information_content": 8570, "description": 7315, "taxon": 1317 } }, { "category": [ "biolink:Gene", "biolink:Protein" ], "count": 10221, "id_prefixes": { "NCBIGene": 10221 }, "attributes": { "name": 10221, "equivalent_identifiers": 10221, "description": 10221, "taxon": 10221, "information_content": 10214 } }, { "category": [ "biolink:Gene" ], "count": 193, "id_prefixes": { "NCBIGene": 178, "HGNC": 15 }, "attributes": { "name": 193, "equivalent_identifiers": 193, "description": 175, "taxon": 175, "information_content": 170 } }, { "category": [ "biolink:PhenotypicFeature" ], "count": 537, "id_prefixes": { "HP": 366, "UMLS": 126, "NCIT": 20, "MESH": 17, "EFO": 8 }, "attributes": { "name": 537, "equivalent_identifiers": 537, "information_content": 393, "description": 382, "taxon": 365 } }, { "category": [ "biolink:GrossAnatomicalStructure" ], "count": 2, "id_prefixes": { "UBERON": 2 }, "attributes": { "name": 2, "equivalent_identifiers": 2, "information_content": 2, "description": 2 } }, { "category": [ "biolink:BiologicalEntity" ], "count": 10, "id_prefixes": { "UMLS": 10 }, "attributes": { "name": 10, "equivalent_identifiers": 10 } }, { "category": [ "biolink:Phenomenon" ], "count": 277, "id_prefixes": { "UMLS": 277 }, "attributes": { "name": 277, "equivalent_identifiers": 277 } }, { "category": [ "biolink:BiologicalProcess" ], "count": 5, "id_prefixes": { "UMLS": 4, "GO": 1 }, "attributes": { "name": 5, "equivalent_identifiers": 5, "information_content": 1, "description": 1 } }, { "category": [ "biolink:ClinicalFinding" ], "count": 1, "id_prefixes": { "UMLS": 1 }, "attributes": { "name": 1, "equivalent_identifiers": 1 } }, { "category": [ "biolink:AnatomicalEntity" ], "count": 1, "id_prefixes": { "UMLS": 1 }, "attributes": { "name": 1, "equivalent_identifiers": 1 } }, { "category": [ "biolink:Behavior" ], "count": 4, "id_prefixes": { "UMLS": 4 }, "attributes": { "name": 4, "equivalent_identifiers": 4 } }, { "category": [ "biolink:ClinicalAttribute" ], "count": 1, "id_prefixes": { "UMLS": 1 }, "attributes": { "name": 1, "equivalent_identifiers": 1 } }, { "category": [ "biolink:SmallMolecule", "biolink:Drug" ], "count": 1290, "id_prefixes": { "CHEBI": 1187, "UNII": 101, "PUBCHEM.COMPOUND": 2 }, "attributes": { "name": 1290, "equivalent_identifiers": 1290, "information_content": 1183, "description": 901 } }, { "category": [ "biolink:SmallMolecule" ], "count": 266450, "id_prefixes": { "PUBCHEM.COMPOUND": 249291, "CHEMBL.COMPOUND": 9871, "CHEBI": 3815, "UNII": 3310, "GTOPDB": 163 }, "attributes": { "name": 266450, "equivalent_identifiers": 266450, "information_content": 3815, "description": 1513 } }, { "category": [ "biolink:MolecularMixture" ], "count": 11298, "id_prefixes": { "PUBCHEM.COMPOUND": 10404, "CHEMBL.COMPOUND": 530, "UNII": 226, "CHEBI": 134, "GTOPDB": 4 }, "attributes": { "name": 11298, "equivalent_identifiers": 11298, "information_content": 134, "description": 79 } }, { "category": [ "biolink:Drug" ], "count": 174, "id_prefixes": { "UNII": 134, "CHEBI": 39, "CHEMBL.COMPOUND": 1 }, "attributes": { "name": 174, "equivalent_identifiers": 174, "information_content": 38, "description": 22 } }, { "category": [ "biolink:SmallMolecule", "biolink:MolecularMixture" ], "count": 9, "id_prefixes": { "CHEBI": 7, "UNII": 2 }, "attributes": { "name": 9, "equivalent_identifiers": 9, "information_content": 7, "description": 2 } }, { "category": [ "biolink:SmallMolecule", "biolink:Food", "biolink:Drug" ], "count": 1, "id_prefixes": { "CHEBI": 1 }, "attributes": { "name": 1, "equivalent_identifiers": 1, "information_content": 1, "description": 1 } }, { "category": [ "biolink:ChemicalEntity" ], "count": 100, "id_prefixes": { "UNII": 53, "CHEBI": 43, "CHEMBL.COMPOUND": 4 }, "attributes": { "name": 100, "equivalent_identifiers": 100, "information_content": 43, "description": 29 } }, { "category": [ "biolink:SmallMolecule", "biolink:Protein", "biolink:Drug" ], "count": 1, "id_prefixes": { "UNII": 1 }, "attributes": { "name": 1, "equivalent_identifiers": 1 } } ], "nodes_summary": { "total_count": 300515, "id_prefixes": { "PUBCHEM.COMPOUND": 259697, "CHEMBL.COMPOUND": 10406, "NCBIGene": 10399, "MONDO": 8354, "CHEBI": 5226, "UNII": 3827, "UMLS": 1751, "HP": 366, "GTOPDB": 167, "OMIM": 123, "DOID": 55, "MESH": 55, "orphanet": 37, "NCIT": 20, "HGNC": 15, "EFO": 14, "UBERON": 2, "GO": 1 }, "attributes": { "name": 300515, "equivalent_identifiers": 300515, "information_content": 24571, "description": 20643, "taxon": 12078 } }, "edges": [ { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:Disease" ], "count": 133687, "primary_knowledge_sources": { "infores:disgenet": 63417, "infores:ctd": 31241, "infores:eram": 12737, "infores:diseases": 12267, "infores:monarchinitiative": 8573, "infores:uniprot": 5452 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 133687, "knowledge_level": 133687, "agent_type": 133687, "original_subject": 133687, "original_object": 133687, "score": 63417 }, "subject_id_prefixes": { "NCBIGene": 133687 }, "object_id_prefixes": { "MONDO": 115277, "UMLS": 16042, "MESH": 1261, "DOID": 527, "OMIM": 330, "EFO": 168, "orphanet": 82 } }, { "subject_category": [ "biolink:Gene" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:Disease" ], "count": 1165, "primary_knowledge_sources": { "infores:disgenet": 607, "infores:ctd": 260, "infores:eram": 114, "infores:diseases": 82, "infores:monarchinitiative": 55, "infores:uniprot": 47 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 1165, "knowledge_level": 1165, "agent_type": 1165, "original_subject": 1165, "original_object": 1165, "score": 607 }, "subject_id_prefixes": { "NCBIGene": 1095, "HGNC": 70 }, "object_id_prefixes": { "MONDO": 971, "UMLS": 180, "MESH": 8, "DOID": 6 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:Gene" ], "count": 10, "primary_knowledge_sources": { "infores:monarchinitiative": 6, "infores:ctd": 3, "infores:uniprot": 1 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 10, "knowledge_level": 10, "agent_type": 10, "original_subject": 10, "original_object": 10 }, "subject_id_prefixes": { "NCBIGene": 10 }, "object_id_prefixes": { "NCBIGene": 10 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 4, "primary_knowledge_sources": { "infores:uniprot": 4 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 4, "knowledge_level": 4, "agent_type": 4, "original_subject": 4, "original_object": 4 }, "subject_id_prefixes": { "NCBIGene": 4 }, "object_id_prefixes": { "NCBIGene": 4 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 8537, "primary_knowledge_sources": { "infores:disgenet": 6987, "infores:ctd": 1509, "infores:monarchinitiative": 41 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 8537, "knowledge_level": 8537, "agent_type": 8537, "original_subject": 8537, "original_object": 8537, "score": 6987 }, "subject_id_prefixes": { "NCBIGene": 8537 }, "object_id_prefixes": { "HP": 6078, "UMLS": 1470, "NCIT": 624, "MESH": 217, "EFO": 148 } }, { "subject_category": [ "biolink:Gene" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 52, "primary_knowledge_sources": { "infores:disgenet": 40, "infores:ctd": 12 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 52, "knowledge_level": 52, "agent_type": 52, "original_subject": 52, "original_object": 52, "score": 40 }, "subject_id_prefixes": { "NCBIGene": 49, "HGNC": 3 }, "object_id_prefixes": { "HP": 26, "UMLS": 18, "MESH": 4, "NCIT": 2, "EFO": 2 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:GrossAnatomicalStructure" ], "count": 14, "primary_knowledge_sources": { "infores:ctd": 14 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 14, "knowledge_level": 14, "agent_type": 14, "original_subject": 14, "original_object": 14 }, "subject_id_prefixes": { "NCBIGene": 14 }, "object_id_prefixes": { "UBERON": 14 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:BiologicalEntity" ], "count": 1296, "primary_knowledge_sources": { "infores:disgenet": 1296 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 1296, "knowledge_level": 1296, "agent_type": 1296, "score": 1296, "original_subject": 1296, "original_object": 1296 }, "subject_id_prefixes": { "NCBIGene": 1296 }, "object_id_prefixes": { "UMLS": 1296 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:Phenomenon" ], "count": 1331, "primary_knowledge_sources": { "infores:disgenet": 1331 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 1331, "knowledge_level": 1331, "agent_type": 1331, "score": 1331, "original_subject": 1331, "original_object": 1331 }, "subject_id_prefixes": { "NCBIGene": 1331 }, "object_id_prefixes": { "UMLS": 1331 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 17, "primary_knowledge_sources": { "infores:disgenet": 17 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 17, "knowledge_level": 17, "agent_type": 17, "score": 17, "original_subject": 17, "original_object": 17 }, "subject_id_prefixes": { "NCBIGene": 17 }, "object_id_prefixes": { "UMLS": 16, "GO": 1 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:ClinicalFinding" ], "count": 1, "primary_knowledge_sources": { "infores:disgenet": 1 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 1, "knowledge_level": 1, "agent_type": 1, "score": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "NCBIGene": 1 }, "object_id_prefixes": { "UMLS": 1 } }, { "subject_category": [ "biolink:Gene" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:Phenomenon" ], "count": 19, "primary_knowledge_sources": { "infores:disgenet": 19 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 19, "knowledge_level": 19, "agent_type": 19, "score": 19, "original_subject": 19, "original_object": 19 }, "subject_id_prefixes": { "NCBIGene": 17, "HGNC": 2 }, "object_id_prefixes": { "UMLS": 19 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:AnatomicalEntity" ], "count": 8, "primary_knowledge_sources": { "infores:disgenet": 8 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 8, "knowledge_level": 8, "agent_type": 8, "score": 8, "original_subject": 8, "original_object": 8 }, "subject_id_prefixes": { "NCBIGene": 8 }, "object_id_prefixes": { "UMLS": 8 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:Behavior" ], "count": 6, "primary_knowledge_sources": { "infores:disgenet": 6 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 6, "knowledge_level": 6, "agent_type": 6, "score": 6, "original_subject": 6, "original_object": 6 }, "subject_id_prefixes": { "NCBIGene": 6 }, "object_id_prefixes": { "UMLS": 6 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:ClinicalAttribute" ], "count": 2, "primary_knowledge_sources": { "infores:disgenet": 2 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 2, "knowledge_level": 2, "agent_type": 2, "score": 2, "original_subject": 2, "original_object": 2 }, "subject_id_prefixes": { "NCBIGene": 2 }, "object_id_prefixes": { "UMLS": 2 } }, { "subject_category": [ "biolink:Gene" ], "predicate": "biolink:genetically_associated_with", "object_category": [ "biolink:BiologicalEntity" ], "count": 2, "primary_knowledge_sources": { "infores:disgenet": 2 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 2, "knowledge_level": 2, "agent_type": 2, "score": 2, "original_subject": 2, "original_object": 2 }, "subject_id_prefixes": { "NCBIGene": 2 }, "object_id_prefixes": { "UMLS": 2 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:target_for", "object_category": [ "biolink:Disease" ], "count": 3467, "primary_knowledge_sources": { "infores:drugcentral": 3467 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 3467, "knowledge_level": 3467, "agent_type": 3467, "original_subject": 3467, "original_object": 3467 }, "subject_id_prefixes": { "NCBIGene": 3467 }, "object_id_prefixes": { "MONDO": 3427, "DOID": 40 } }, { "subject_category": [ "biolink:Gene" ], "predicate": "biolink:target_for", "object_category": [ "biolink:Disease" ], "count": 14, "primary_knowledge_sources": { "infores:drugcentral": 14 }, "qualifiers": {}, "attributes": { "aggregator_knowledge_source": 14, "knowledge_level": 14, "agent_type": 14, "original_subject": 14, "original_object": 14 }, "subject_id_prefixes": { "NCBIGene": 13, "HGNC": 1 }, "object_id_prefixes": { "MONDO": 14 } }, { "subject_category": [ "biolink:SmallMolecule", "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 4959, "primary_knowledge_sources": { "infores:pharos": 4959 }, "qualifiers": { "object_aspect_qualifier": 4959, "object_direction_qualifier": 4925, "qualified_predicate": 4925 }, "attributes": { "knowledge_level": 4959, "agent_type": 4959, "original_subject": 4959, "original_object": 4959, "affinity": 4154, "affinity_parameter": 4154, "publications": 2710 }, "subject_id_prefixes": { "CHEBI": 4769, "UNII": 188, "PUBCHEM.COMPOUND": 2 }, "object_id_prefixes": { "NCBIGene": 4959 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 363583, "primary_knowledge_sources": { "infores:pharos": 363583 }, "qualifiers": { "object_aspect_qualifier": 363583, "object_direction_qualifier": 363580, "qualified_predicate": 363580 }, "attributes": { "knowledge_level": 363583, "agent_type": 363583, "original_subject": 363583, "original_object": 363583, "affinity": 363311, "affinity_parameter": 363311, "publications": 329342 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 336674, "CHEMBL.COMPOUND": 12950, "CHEBI": 7869, "UNII": 5922, "GTOPDB": 168 }, "object_id_prefixes": { "NCBIGene": 363583 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 16139, "primary_knowledge_sources": { "infores:pharos": 16139 }, "qualifiers": { "object_aspect_qualifier": 16139, "object_direction_qualifier": 16138, "qualified_predicate": 16138 }, "attributes": { "knowledge_level": 16139, "agent_type": 16139, "original_subject": 16139, "original_object": 16139, "affinity": 16105, "affinity_parameter": 16105, "publications": 14080 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 14733, "CHEMBL.COMPOUND": 785, "UNII": 369, "CHEBI": 252 }, "object_id_prefixes": { "NCBIGene": 16139 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:related_to", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 6, "primary_knowledge_sources": { "infores:pharos": 6 }, "qualifiers": {}, "attributes": { "knowledge_level": 6, "agent_type": 6, "original_subject": 6, "original_object": 6, "affinity": 5, "publications": 4, "affinity_parameter": 1 }, "subject_id_prefixes": { "CHEBI": 5, "UNII": 1 }, "object_id_prefixes": { "NCBIGene": 6 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 222, "primary_knowledge_sources": { "infores:pharos": 222 }, "qualifiers": { "object_aspect_qualifier": 222, "object_direction_qualifier": 222, "qualified_predicate": 222 }, "attributes": { "knowledge_level": 222, "agent_type": 222, "original_subject": 222, "original_object": 222, "affinity": 172, "affinity_parameter": 171, "publications": 97 }, "subject_id_prefixes": { "CHEBI": 138, "UNII": 79, "CHEMBL.COMPOUND": 5 }, "object_id_prefixes": { "NCBIGene": 222 } }, { "subject_category": [ "biolink:SmallMolecule", "biolink:Drug" ], "predicate": "biolink:related_to", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 405, "primary_knowledge_sources": { "infores:pharos": 405 }, "qualifiers": {}, "attributes": { "knowledge_level": 405, "agent_type": 405, "original_subject": 405, "original_object": 405, "affinity": 399, "publications": 394, "affinity_parameter": 145 }, "subject_id_prefixes": { "CHEBI": 401, "UNII": 4 }, "object_id_prefixes": { "NCBIGene": 405 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:related_to", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 2637, "primary_knowledge_sources": { "infores:pharos": 2637 }, "qualifiers": {}, "attributes": { "knowledge_level": 2637, "agent_type": 2637, "affinity": 2637, "original_subject": 2637, "original_object": 2637, "publications": 2618, "affinity_parameter": 851 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 1360, "CHEBI": 939, "UNII": 225, "GTOPDB": 105, "CHEMBL.COMPOUND": 8 }, "object_id_prefixes": { "NCBIGene": 2637 } }, { "subject_category": [ "biolink:SmallMolecule", "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 15, "primary_knowledge_sources": { "infores:pharos": 15 }, "qualifiers": { "object_aspect_qualifier": 15, "object_direction_qualifier": 15, "qualified_predicate": 15 }, "attributes": { "knowledge_level": 15, "agent_type": 15, "original_subject": 15, "original_object": 15, "affinity": 11, "affinity_parameter": 11, "publications": 7 }, "subject_id_prefixes": { "CHEBI": 12, "UNII": 3 }, "object_id_prefixes": { "NCBIGene": 15 } }, { "subject_category": [ "biolink:SmallMolecule", "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 16, "primary_knowledge_sources": { "infores:pharos": 16 }, "qualifiers": { "object_aspect_qualifier": 16, "object_direction_qualifier": 16, "qualified_predicate": 16 }, "attributes": { "knowledge_level": 16, "agent_type": 16, "original_subject": 16, "original_object": 16, "affinity": 12, "affinity_parameter": 12, "publications": 8 }, "subject_id_prefixes": { "CHEBI": 14, "UNII": 2 }, "object_id_prefixes": { "NCBIGene": 16 } }, { "subject_category": [ "biolink:SmallMolecule", "biolink:Food", "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 5, "primary_knowledge_sources": { "infores:pharos": 5 }, "qualifiers": { "object_aspect_qualifier": 5, "object_direction_qualifier": 5, "qualified_predicate": 5 }, "attributes": { "knowledge_level": 5, "agent_type": 5, "affinity": 5, "affinity_parameter": 5, "original_subject": 5, "original_object": 5, "publications": 5 }, "subject_id_prefixes": { "CHEBI": 5 }, "object_id_prefixes": { "NCBIGene": 5 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 168, "primary_knowledge_sources": { "infores:pharos": 168 }, "qualifiers": { "object_aspect_qualifier": 168, "object_direction_qualifier": 168, "qualified_predicate": 168 }, "attributes": { "knowledge_level": 168, "agent_type": 168, "original_subject": 168, "original_object": 168, "affinity": 161, "affinity_parameter": 161, "publications": 137 }, "subject_id_prefixes": { "UNII": 94, "CHEBI": 70, "CHEMBL.COMPOUND": 4 }, "object_id_prefixes": { "NCBIGene": 168 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 3, "primary_knowledge_sources": { "infores:pharos": 3 }, "qualifiers": { "object_aspect_qualifier": 3, "object_direction_qualifier": 3, "qualified_predicate": 3 }, "attributes": { "knowledge_level": 3, "agent_type": 3, "original_subject": 3, "original_object": 3, "affinity": 2, "affinity_parameter": 2, "publications": 2 }, "subject_id_prefixes": { "CHEBI": 3 }, "object_id_prefixes": { "NCBIGene": 3 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 184, "primary_knowledge_sources": { "infores:pharos": 184 }, "qualifiers": {}, "attributes": { "knowledge_level": 184, "agent_type": 184, "original_subject": 184, "original_object": 184, "affinity": 125, "affinity_parameter": 125, "publications": 54 }, "subject_id_prefixes": { "UNII": 130, "CHEBI": 54 }, "object_id_prefixes": { "NCBIGene": 184 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 10509, "primary_knowledge_sources": { "infores:pharos": 10509 }, "qualifiers": {}, "attributes": { "knowledge_level": 10509, "agent_type": 10509, "original_subject": 10509, "original_object": 10509, "affinity": 10505, "affinity_parameter": 10505, "publications": 10031 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 8278, "CHEBI": 1388, "UNII": 540, "CHEMBL.COMPOUND": 256, "GTOPDB": 47 }, "object_id_prefixes": { "NCBIGene": 10509 } }, { "subject_category": [ "biolink:SmallMolecule", "biolink:Drug" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 619, "primary_knowledge_sources": { "infores:pharos": 619 }, "qualifiers": {}, "attributes": { "knowledge_level": 619, "agent_type": 619, "original_subject": 619, "original_object": 619, "affinity": 611, "affinity_parameter": 611, "publications": 591 }, "subject_id_prefixes": { "CHEBI": 590, "UNII": 29 }, "object_id_prefixes": { "NCBIGene": 619 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 49, "primary_knowledge_sources": { "infores:pharos": 49 }, "qualifiers": {}, "attributes": { "knowledge_level": 49, "agent_type": 49, "affinity": 49, "affinity_parameter": 49, "original_subject": 49, "original_object": 49, "publications": 48 }, "subject_id_prefixes": { "UNII": 36, "CHEBI": 13 }, "object_id_prefixes": { "NCBIGene": 49 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene" ], "count": 1, "primary_knowledge_sources": { "infores:pharos": 1 }, "qualifiers": {}, "attributes": { "knowledge_level": 1, "agent_type": 1, "affinity": 1, "affinity_parameter": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "UNII": 1 }, "object_id_prefixes": { "HGNC": 1 } }, { "subject_category": [ "biolink:SmallMolecule", "biolink:Protein", "biolink:Drug" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 1, "primary_knowledge_sources": { "infores:pharos": 1 }, "qualifiers": {}, "attributes": { "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1, "affinity": 1, "affinity_parameter": 1 }, "subject_id_prefixes": { "UNII": 1 }, "object_id_prefixes": { "NCBIGene": 1 } }, { "subject_category": [ "biolink:SmallMolecule", "biolink:Protein", "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 10, "primary_knowledge_sources": { "infores:pharos": 10 }, "qualifiers": { "object_aspect_qualifier": 10, "object_direction_qualifier": 10, "qualified_predicate": 10 }, "attributes": { "knowledge_level": 10, "agent_type": 10, "original_subject": 10, "original_object": 10, "affinity": 1, "affinity_parameter": 1 }, "subject_id_prefixes": { "UNII": 10 }, "object_id_prefixes": { "NCBIGene": 10 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 1089, "primary_knowledge_sources": { "infores:pharos": 1089 }, "qualifiers": { "object_aspect_qualifier": 1089, "object_direction_qualifier": 1089, "qualified_predicate": 1089 }, "attributes": { "knowledge_level": 1089, "agent_type": 1089, "affinity": 1089, "affinity_parameter": 1089, "original_subject": 1089, "original_object": 1089, "publications": 1080 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 1000, "CHEBI": 38, "UNII": 34, "CHEMBL.COMPOUND": 16, "GTOPDB": 1 }, "object_id_prefixes": { "NCBIGene": 1064, "HGNC": 25 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 482, "primary_knowledge_sources": { "infores:pharos": 482 }, "qualifiers": {}, "attributes": { "knowledge_level": 482, "agent_type": 482, "affinity": 482, "affinity_parameter": 482, "original_subject": 482, "original_object": 482, "publications": 471 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 397, "CHEMBL.COMPOUND": 44, "UNII": 38, "CHEBI": 2, "GTOPDB": 1 }, "object_id_prefixes": { "NCBIGene": 482 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 4, "primary_knowledge_sources": { "infores:pharos": 4 }, "qualifiers": { "object_aspect_qualifier": 4, "object_direction_qualifier": 4, "qualified_predicate": 4 }, "attributes": { "knowledge_level": 4, "agent_type": 4, "original_subject": 4, "original_object": 4 }, "subject_id_prefixes": { "UNII": 4 }, "object_id_prefixes": { "HGNC": 4 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:related_to", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 4, "primary_knowledge_sources": { "infores:pharos": 4 }, "qualifiers": {}, "attributes": { "knowledge_level": 4, "agent_type": 4, "original_subject": 4, "original_object": 4, "affinity": 3, "affinity_parameter": 3 }, "subject_id_prefixes": { "UNII": 4 }, "object_id_prefixes": { "NCBIGene": 4 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:related_to", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 12, "primary_knowledge_sources": { "infores:pharos": 12 }, "qualifiers": {}, "attributes": { "knowledge_level": 12, "agent_type": 12, "affinity": 12, "publications": 12, "original_subject": 12, "original_object": 12, "affinity_parameter": 9 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 6, "GTOPDB": 3, "UNII": 3 }, "object_id_prefixes": { "NCBIGene": 12 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene" ], "count": 43, "primary_knowledge_sources": { "infores:pharos": 43 }, "qualifiers": {}, "attributes": { "knowledge_level": 43, "agent_type": 43, "affinity": 43, "affinity_parameter": 43, "original_subject": 43, "original_object": 43, "publications": 42 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 20, "CHEBI": 19, "CHEMBL.COMPOUND": 3, "UNII": 1 }, "object_id_prefixes": { "NCBIGene": 43 } }, { "subject_category": [ "biolink:SmallMolecule", "biolink:Drug" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene" ], "count": 4, "primary_knowledge_sources": { "infores:pharos": 4 }, "qualifiers": {}, "attributes": { "knowledge_level": 4, "agent_type": 4, "affinity": 4, "affinity_parameter": 4, "publications": 4, "original_subject": 4, "original_object": 4 }, "subject_id_prefixes": { "CHEBI": 4 }, "object_id_prefixes": { "NCBIGene": 4 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 102, "primary_knowledge_sources": { "infores:pharos": 102 }, "qualifiers": { "object_aspect_qualifier": 102, "object_direction_qualifier": 102, "qualified_predicate": 102 }, "attributes": { "knowledge_level": 102, "agent_type": 102, "affinity": 102, "affinity_parameter": 102, "original_subject": 102, "original_object": 102, "publications": 92 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 101, "UNII": 1 }, "object_id_prefixes": { "NCBIGene": 102 } }, { "subject_category": [ "biolink:SmallMolecule", "biolink:MolecularMixture" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 1, "primary_knowledge_sources": { "infores:pharos": 1 }, "qualifiers": {}, "attributes": { "knowledge_level": 1, "agent_type": 1, "affinity": 1, "affinity_parameter": 1, "publications": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "UNII": 1 }, "object_id_prefixes": { "NCBIGene": 1 } } ], "edges_summary": { "total_count": 550904, "predicates": { "biolink:affects": 386315, "biolink:genetically_associated_with": 146151, "biolink:directly_physically_interacts_with": 11893, "biolink:target_for": 3481, "biolink:related_to": 3064 }, "primary_knowledge_sources": { "infores:pharos": 401272, "infores:disgenet": 73733, "infores:ctd": 33039, "infores:eram": 12851, "infores:diseases": 12349, "infores:monarchinitiative": 8675, "infores:uniprot": 5504, "infores:drugcentral": 3481 }, "predicates_by_knowledge_source": { "infores:uniprot": { "biolink:genetically_associated_with": 5504 }, "infores:monarchinitiative": { "biolink:genetically_associated_with": 8675 }, "infores:ctd": { "biolink:genetically_associated_with": 33039 }, "infores:eram": { "biolink:genetically_associated_with": 12851 }, "infores:disgenet": { "biolink:genetically_associated_with": 73733 }, "infores:diseases": { "biolink:genetically_associated_with": 12349 }, "infores:drugcentral": { "biolink:target_for": 3481 }, "infores:pharos": { "biolink:affects": 386315, "biolink:directly_physically_interacts_with": 11893, "biolink:related_to": 3064 } }, "qualifiers": { "object_aspect_qualifier": 386315, "object_direction_qualifier": 386277, "qualified_predicate": 386277 }, "attributes": { "knowledge_level": 550904, "agent_type": 550904, "original_subject": 550904, "original_object": 550904, "affinity": 400003, "affinity_parameter": 397955, "publications": 361830, "aggregator_knowledge_source": 149632, "score": 73733 } } } }