{
    "source_type": "primary",
    "edges": [
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:BiologicalProcess",
            "predicate": "biolink:subclass_of",
            "subject_id": "REACT:R-DDI-5672017",
            "object_id": "GO:0016241"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "subject_id": "REACT:R-HSA-9626253",
            "object_id": "GO:0061684"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:Pathway",
            "predicate": "biolink:subclass_of",
            "subject_id": "REACT:R-CEL-391375",
            "object_id": "GO:0038194"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:Pathway",
            "predicate": "biolink:occurs_in",
            "subject_id": "REACT:R-HSA-9834070",
            "object_id": "REACT:R-HSA-5205685"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:SmallMolecule",
            "predicate": "biolink:has_output",
            "subject_id": "REACT:R-SCE-9639286",
            "object_id": "CHEBI:37565"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:SmallMolecule",
            "predicate": "biolink:has_input",
            "subject_id": "REACT:R-DME-165129",
            "object_id": "CHEBI:37565"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:Drug",
            "predicate": "biolink:has_output",
            "subject_id": "REACT:R-GGA-433593",
            "object_id": "CHEBI:15377"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:Drug",
            "predicate": "biolink:has_input",
            "subject_id": "REACT:R-GGA-433608",
            "object_id": "CHEBI:15377"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:ChemicalEntity",
            "predicate": "biolink:has_output",
            "subject_id": "REACT:R-HSA-3223236",
            "object_id": "CHEBI:26523"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:ChemicalEntity",
            "predicate": "biolink:has_input",
            "subject_id": "REACT:R-PFA-9857090",
            "object_id": "CHEBI:26523"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:MolecularMixture",
            "predicate": "biolink:has_output",
            "subject_id": "REACT:R-SPO-191101",
            "object_id": "CHEBI:17306"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:MolecularMixture",
            "predicate": "biolink:has_input",
            "subject_id": "REACT:R-CEL-433101",
            "object_id": "CHEBI:30031"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:ChemicalMixture",
            "predicate": "biolink:has_input",
            "subject_id": "REACT:R-HSA-9911463",
            "object_id": "CHEBI:78435"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:MolecularActivity",
            "predicate": "biolink:precedes",
            "subject_id": "REACT:R-HSA-9626034",
            "object_id": "REACT:R-HSA-9626046"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:MolecularActivity",
            "predicate": "biolink:occurs_in",
            "subject_id": "REACT:R-HSA-5658435",
            "object_id": "REACT:R-HSA-9651280"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:Protein",
            "predicate": "biolink:has_output",
            "subject_id": "REACT:R-HSA-9626034",
            "object_id": "NCBIGene:1915"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:Protein",
            "predicate": "biolink:has_input",
            "subject_id": "REACT:R-HSA-9626046",
            "object_id": "NCBIGene:1915"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:Gene",
            "predicate": "biolink:has_output",
            "subject_id": "REACT:R-HSA-9626034",
            "object_id": "NCBIGene:1915"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:Gene",
            "predicate": "biolink:has_input",
            "subject_id": "REACT:R-HSA-9626046",
            "object_id": "NCBIGene:1915"
        },
        {
            "subject_category": "biolink:MolecularActivity",
            "object_category": "biolink:CellularComponent",
            "predicate": "biolink:occurs_in",
            "subject_id": "REACT:R-HSA-9626034",
            "object_id": "GO:0005765"
        },
        {
            "subject_category": "biolink:BiologicalProcess",
            "object_category": "biolink:Pathway",
            "predicate": "biolink:precedes",
            "subject_id": "GO:0007091",
            "object_id": "REACT:R-HSA-69618"
        },
        {
            "subject_category": "biolink:BiologicalProcess",
            "object_category": "biolink:Pathway",
            "predicate": "biolink:occurs_in",
            "subject_id": "REACT:R-HSA-9853402",
            "object_id": "REACT:R-HSA-9925563"
        },
        {
            "subject_category": "biolink:BiologicalProcess",
            "object_category": "biolink:BiologicalProcess",
            "predicate": "biolink:subclass_of",
            "subject_id": "GO:0051090",
            "object_id": "GO:0006355"
        },
        {
            "subject_category": "biolink:BiologicalProcess",
            "object_category": "biolink:BiologicalProcess",
            "predicate": "biolink:precedes",
            "subject_id": "REACT:R-HSA-9910607",
            "object_id": "REACT:R-HSA-9909305"
        },
        {
            "subject_category": "biolink:BiologicalProcess",
            "object_category": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "subject_id": "REACT:R-HSA-9727355",
            "object_id": "GO:0003334"
        },
        {
            "subject_category": "biolink:BiologicalProcess",
            "object_category": "biolink:CellularComponent",
            "predicate": "biolink:occurs_in",
            "subject_id": "REACT:R-HSA-9725621",
            "object_id": "GO:0005576"
        },
        {
            "subject_category": "biolink:Pathway",
            "object_category": "biolink:BiologicalProcess",
            "predicate": "biolink:subclass_of",
            "subject_id": "REACT:R-HSA-5205685",
            "object_id": "GO:0016236"
        },
        {
            "subject_category": "biolink:Pathway",
            "object_category": "biolink:BiologicalProcess",
            "predicate": "biolink:occurs_in",
            "subject_id": "REACT:R-HSA-9663891",
            "object_id": "GO:0016236"
        },
        {
            "subject_category": "biolink:Pathway",
            "object_category": "biolink:BiologicalProcess",
            "predicate": "biolink:precedes",
            "subject_id": "REACT:R-HSA-69242",
            "object_id": "GO:0000082"
        },
        {
            "subject_category": "biolink:Pathway",
            "object_category": "biolink:Pathway",
            "predicate": "biolink:subclass_of",
            "subject_id": "REACT:R-SCE-198203",
            "object_id": "GO:0043491"
        },
        {
            "subject_category": "biolink:Pathway",
            "object_category": "biolink:Pathway",
            "predicate": "biolink:occurs_in",
            "subject_id": "REACT:R-HSA-69618",
            "object_id": "REACT:R-HSA-69620"
        },
        {
            "subject_category": "biolink:Pathway",
            "object_category": "biolink:Pathway",
            "predicate": "biolink:precedes",
            "subject_id": "REACT:R-HSA-141405",
            "object_id": "REACT:R-HSA-141424"
        },
        {
            "subject_category": "biolink:Pathway",
            "object_category": "biolink:CellularComponent",
            "predicate": "biolink:occurs_in",
            "subject_id": "REACT:R-HSA-9663891",
            "object_id": "GO:0034045"
        },
        {
            "subject_category": "biolink:SmallMolecule",
            "object_category": "biolink:Cell",
            "predicate": "biolink:located_in",
            "subject_id": "CHEBI:17898",
            "object_id": "CL:0002586"
        },
        {
            "subject_category": "biolink:SmallMolecule",
            "object_category": "biolink:Protein",
            "predicate": "biolink:affects",
            "subject_id": "CHEBI:57406",
            "object_id": "NCBIGene:6662",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "expression"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:SmallMolecule",
            "object_category": "biolink:Gene",
            "predicate": "biolink:affects",
            "subject_id": "CHEBI:57406",
            "object_id": "NCBIGene:6662",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "expression"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:Drug",
            "object_category": "biolink:Cell",
            "predicate": "biolink:located_in",
            "subject_id": "CHEBI:12777",
            "object_id": "CL:0002586"
        },
        {
            "subject_category": "biolink:Drug",
            "object_category": "biolink:Protein",
            "predicate": "biolink:affects",
            "subject_id": "CHEBI:15367",
            "object_id": "NCBIGene:18504",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "expression"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:Drug",
            "object_category": "biolink:Gene",
            "predicate": "biolink:affects",
            "subject_id": "CHEBI:15367",
            "object_id": "NCBIGene:18504",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "expression"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:Cell",
            "predicate": "biolink:located_in",
            "subject_id": "NCBIGene:2641",
            "object_id": "CL:0000171"
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:located_in",
            "subject_id": "NCBIGene:19879",
            "object_id": "UBERON:0008404"
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:Protein",
            "predicate": "biolink:affects",
            "subject_id": "NCBIGene:7547",
            "object_id": "NCBIGene:79923",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "expression"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:Gene",
            "predicate": "biolink:affects",
            "subject_id": "NCBIGene:7547",
            "object_id": "NCBIGene:79923",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "expression"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:Gene",
            "object_category": "biolink:Cell",
            "predicate": "biolink:located_in",
            "subject_id": "NCBIGene:2641",
            "object_id": "CL:0000171"
        },
        {
            "subject_category": "biolink:Gene",
            "object_category": "biolink:GrossAnatomicalStructure",
            "predicate": "biolink:located_in",
            "subject_id": "NCBIGene:19879",
            "object_id": "UBERON:0008404"
        },
        {
            "subject_category": "biolink:Gene",
            "object_category": "biolink:Protein",
            "predicate": "biolink:affects",
            "subject_id": "NCBIGene:7547",
            "object_id": "NCBIGene:79923",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "expression"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:Gene",
            "object_category": "biolink:Gene",
            "predicate": "biolink:affects",
            "subject_id": "NCBIGene:7547",
            "object_id": "NCBIGene:79923",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "expression"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:Pathway",
            "predicate": "biolink:disease_has_basis_in",
            "subject_id": "MONDO:0004992",
            "object_id": "REACT:R-HSA-9630747"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:BiologicalProcess",
            "predicate": "biolink:disease_has_basis_in",
            "subject_id": "MONDO:0005446",
            "object_id": "GO:0060326"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:MolecularActivity",
            "predicate": "biolink:disease_has_basis_in",
            "subject_id": "MONDO:0004992",
            "object_id": "REACT:R-HSA-9630795"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:SmallMolecule",
            "predicate": "biolink:has_part",
            "subject_id": "MONDO:0019086",
            "object_id": "CHEBI:37565"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:Protein",
            "predicate": "biolink:has_part",
            "subject_id": "MONDO:0005091",
            "object_id": "NCBIGene:1915"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:Gene",
            "predicate": "biolink:has_part",
            "subject_id": "MONDO:0005091",
            "object_id": "NCBIGene:1915"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:ChemicalEntity",
            "predicate": "biolink:has_part",
            "subject_id": "MONDO:0004992",
            "object_id": "CHEBI:28815"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:Drug",
            "predicate": "biolink:has_part",
            "subject_id": "MONDO:0005498",
            "object_id": "CHEBI:29105"
        }
    ]
}