{"subject": "NCBITaxon:1661386", "predicate": "biolink:subclass_of", "object": "NCBITaxon:286", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1661386", "original_object": "NCBITaxon:286"}
{"subject": "CAID:CA8102820", "predicate": "biolink:is_nearby_variant_of", "object": "NCBIGene:25894", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "upstream_gene_variant", "distance_to_feature": 95193, "original_subject": "CAID:CA8102820", "original_object": "ENSEMBL:ENSG00000196155"}
{"subject": "CAID:CA8102820", "predicate": "biolink:is_nearby_variant_of", "object": "NCBIGene:25894", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "upstream_gene_variant", "distance_to_feature": 95193, "original_subject": "CAID:CA8102820", "original_object": "ENSEMBL:ENSG00000196155"}
{"subject": "CAID:CA16318245", "predicate": "biolink:is_non_coding_variant_of", "object": "NCBIGene:26047", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "intron_variant", "original_subject": "CAID:CA16318245", "original_object": "ENSEMBL:ENSG00000174469"}
{"subject": "CAID:CA16318245", "predicate": "biolink:is_non_coding_variant_of", "object": "NCBIGene:26047", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "intron_variant", "original_subject": "CAID:CA16318245", "original_object": "ENSEMBL:ENSG00000174469"}
{"subject": "PUBCHEM.COMPOUND:44274699", "predicate": "biolink:affects", "object": "NCBIGene:5770", "ligand": "PUBCHEM.COMPOUND:44274699", "protein": "UniProtKB:P18031", "affinity_parameter": "pIC50", "supporting_affinities": [6.89], "publications": ["PMID:10753467"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 6.89, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:44274699", "original_object": "UniProtKB:P18031", "object_aspect_qualifier": "activity", "object_direction_qualifier": "decreased", "qualified_predicate": "biolink:causes"}
{"subject": "PUBCHEM.COMPOUND:44274699", "predicate": "biolink:affects", "object": "NCBIGene:5770", "ligand": "PUBCHEM.COMPOUND:44274699", "protein": "UniProtKB:P18031", "affinity_parameter": "pIC50", "supporting_affinities": [6.89], "publications": ["PMID:10753467"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 6.89, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:44274699", "original_object": "UniProtKB:P18031", "object_aspect_qualifier": "activity", "object_direction_qualifier": "decreased", "qualified_predicate": "biolink:causes"}
{"subject": "NCBITaxon:1706470", "predicate": "biolink:related_to", "object": "NCBITaxon:1706470", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:1706470", "original_object": "NCBITaxon:1706470"}
{"subject": "NCBIGene:3458", "predicate": "biolink:actively_involved_in", "object": "GO:0006913", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["NCBI gene2go"], "original_subject": "NCBIGene:3458", "original_object": "GO:0006913"}
{"subject": "NCBIGene:3458", "predicate": "biolink:actively_involved_in", "object": "GO:0006913", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["NCBI gene2go"], "original_subject": "NCBIGene:3458", "original_object": "GO:0006913"}
{"subject": "UniProtKB:Q9R0M5-1", "predicate": "biolink:subclass_of", "object": "CHEBI:33579", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:Q9R0M5-1", "original_object": "CHEBI:33579"}
{"subject": "CHEBI:68579", "predicate": "biolink:contributes_to", "object": "MONDO:0002251", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5156547", "PMC:2730547", "PMC:5003057"], "tmkp_confidence_score": 0.6128887859621844, "sentences": "Aside from bleeding, some of the additional side effects of rivaroxaban include the following: dizziness (6%), peripheral edema (6%), hypersensitivity reactions or rash (2%), syncope (2%), and though more rare, thrombocytopenia, agranulocytosis, hepatitis, pruritis, and Stevens?Johnson syndrome.|NA|In the third patient, rivaroxaban was stopped after 23 d, when hepatitis B with seroconversion was diagnosed; the patient died of acute liver failure, mostly due to fatal hepatitis B infection, 48 d after starting treatment.|NA|Non-hemorrhagic adverse effects of rivaroxaban in the EINSTEIN-EXT study were upper abdominal pain, dyspepsia, sinusitis, tooth ache, UTI, back pain and fatigue (all less than 5%) whereas post marketing voluntary reporting of adverse effects include anaphylaxis, angioedema, Stevens-Johnson syndrome, agranulocytosis, jaundice and hepatitis.|NA", "tmkp_ids": ["tmkp:21709dfe811f66a9f620d41080651d41e3d1d379af32db099f3d5a7b494bb6cb", "tmkp:fd2d3e43f75ceac886f3de1b65395369865a1648efc1371ea27bc5b724668584", "tmkp:a62f721434da7ccccc0aee9c2709dc7e571c1caea24237d2ce5dee0cb76a9958"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB06228", "original_object": "MONDO:0002251"}
{"subject": "CHEBI:68579", "predicate": "biolink:contributes_to", "object": "MONDO:0002251", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5156547", "PMC:2730547", "PMC:5003057"], "tmkp_confidence_score": 0.6128887859621844, "sentences": "Aside from bleeding, some of the additional side effects of rivaroxaban include the following: dizziness (6%), peripheral edema (6%), hypersensitivity reactions or rash (2%), syncope (2%), and though more rare, thrombocytopenia, agranulocytosis, hepatitis, pruritis, and Stevens?Johnson syndrome.|NA|In the third patient, rivaroxaban was stopped after 23 d, when hepatitis B with seroconversion was diagnosed; the patient died of acute liver failure, mostly due to fatal hepatitis B infection, 48 d after starting treatment.|NA|Non-hemorrhagic adverse effects of rivaroxaban in the EINSTEIN-EXT study were upper abdominal pain, dyspepsia, sinusitis, tooth ache, UTI, back pain and fatigue (all less than 5%) whereas post marketing voluntary reporting of adverse effects include anaphylaxis, angioedema, Stevens-Johnson syndrome, agranulocytosis, jaundice and hepatitis.|NA", "tmkp_ids": ["tmkp:21709dfe811f66a9f620d41080651d41e3d1d379af32db099f3d5a7b494bb6cb", "tmkp:fd2d3e43f75ceac886f3de1b65395369865a1648efc1371ea27bc5b724668584", "tmkp:a62f721434da7ccccc0aee9c2709dc7e571c1caea24237d2ce5dee0cb76a9958"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB06228", "original_object": "MONDO:0002251"}
{"subject": "NCBIGene:836088", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:836392", "primary_knowledge_source": "infores:intact", "publications": "PMID:30806640", "detection_method": "MI:0892", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UniProtKB:Q9FN94", "original_object": "UniProtKB:Q8GX94"}
{"subject": "NCBIGene:836088", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:836392", "primary_knowledge_source": "infores:intact", "publications": "PMID:30806640", "detection_method": "MI:0892", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UniProtKB:Q9FN94", "original_object": "UniProtKB:Q8GX94"}
{"subject": "NCBIGene:836088", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:836392", "primary_knowledge_source": "infores:intact", "publications": "PMID:30806640", "detection_method": "MI:0892", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UniProtKB:Q9FN94", "original_object": "UniProtKB:Q8GX94"}
{"subject": "NCBIGene:836088", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:836392", "primary_knowledge_source": "infores:intact", "publications": "PMID:30806640", "detection_method": "MI:0892", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UniProtKB:Q9FN94", "original_object": "UniProtKB:Q8GX94"}
{"subject": "NCBITaxon:2390634", "predicate": "biolink:subclass_of", "object": "UBERON:0001062", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:2390634", "original_object": "UBERON:0001062"}
{"subject": "CAID:CA15984545", "predicate": "biolink:affects", "object": "NCBIGene:2551", "primary_knowledge_source": "infores:gtex", "expressed_in": ["UBERON:0002469"], "p_value": [8.69509e-05], "slope": [0.110614], "knowledge_level": "prediction", "agent_type": "computational_model", "original_subject": "HGVS:NC_000021.9:g.25840043C>G", "original_object": "ENSEMBL:ENSG00000154727", "object_aspect_qualifier": "expression", "object_direction_qualifier": "increased", "qualified_predicate": "biolink:causes"}
{"subject": "CAID:CA15984545", "predicate": "biolink:affects", "object": "NCBIGene:2551", "primary_knowledge_source": "infores:gtex", "expressed_in": ["UBERON:0002469"], "p_value": [8.69509e-05], "slope": [0.110614], "knowledge_level": "prediction", "agent_type": "computational_model", "original_subject": "HGVS:NC_000021.9:g.25840043C>G", "original_object": "ENSEMBL:ENSG00000154727", "object_aspect_qualifier": "expression", "object_direction_qualifier": "increased", "qualified_predicate": "biolink:causes"}
{"subject": "CHEBI:114566", "predicate": "biolink:subclass_of", "object": "CHEBI:38166", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:114566", "original_object": "CHEBI:38166"}
{"subject": "NCBIGene:1376", "predicate": "biolink:affects", "object": "PUBCHEM.COMPOUND:131757099", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P23786", "original_object": "HMDB:HMDB0046150", "object_aspect_qualifier": "abundance"}
{"subject": "NCBIGene:1376", "predicate": "biolink:affects", "object": "PUBCHEM.COMPOUND:131757099", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P23786", "original_object": "HMDB:HMDB0046150", "object_aspect_qualifier": "abundance"}
{"object": "CHEBI:29888", "predicate": "biolink:has_participant", "subject": "SMPDB:SMP0048300", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HMDB:HMDB0000250", "original_subject": "SMPDB:SMP0048300"}
{"object": "CHEBI:29888", "predicate": "biolink:has_participant", "subject": "SMPDB:SMP0048300", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HMDB:HMDB0000250", "original_subject": "SMPDB:SMP0048300"}
{"subject": "NCBIGene:4539", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:4728", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000354728", "original_object": "ENSEMBL:ENSP00000315774"}
{"subject": "NCBIGene:4539", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:4728", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000354728", "original_object": "ENSEMBL:ENSP00000315774"}
{"subject": "NCBIGene:4539", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:4728", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000354728", "original_object": "ENSEMBL:ENSP00000315774"}
{"subject": "NCBIGene:4539", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:4728", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "ENSEMBL:ENSP00000354728", "original_object": "ENSEMBL:ENSP00000315774"}
{"subject": "UBERON:0001709", "predicate": "biolink:overlaps", "object": "UBERON:0001434", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001709", "original_object": "UBERON:0001434"}
{"subject": "UMLS:C3536740", "predicate": "biolink:subclass_of", "object": "UMLS:C3273258", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C101202", "original_object": "NCIT:C97151"}
{"subject": "NCBIGene:856756", "predicate": "biolink:subclass_of", "object": "CHEBI:50860", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:P40022", "original_object": "CHEBI:50860"}
{"object": "REACT:R-PFA-77108", "predicate": "biolink:occurs_in", "subject": "REACT:R-PFA-74181", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-PFA-77108", "original_subject": "REACT:R-PFA-74181"}
{"subject": "NCBIGene:100153047", "predicate": "biolink:expressed_in", "object": "CL:0000023", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "not_provided", "id": "uuid:6712b6d8-c4a8-11f0-abf2-8f8ce19e938d", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "provided_by": "bgee_gene_to_expression_edges", "original_subject": "NCBIGene:100153047", "original_object": "CL:0000023"}
{"subject": "NCBIGene:100153047", "predicate": "biolink:expressed_in", "object": "CL:0000023", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "not_provided", "id": "uuid:6712b6d8-c4a8-11f0-abf2-8f8ce19e938d", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "provided_by": "bgee_gene_to_expression_edges", "original_subject": "NCBIGene:100153047", "original_object": "CL:0000023"}
{"subject": "REACT:R-SPO-191983", "predicate": "biolink:has_input", "object": "CHEBI:57783", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SPO-191983", "original_object": "CHEBI:57783"}
{"subject": "NCBIGene:534965", "predicate": "biolink:expressed_in", "object": "UBERON:0001158", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "not_provided", "id": "uuid:4040815b-c4a9-11f0-abf2-8f8ce19e938d", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "provided_by": "bgee_gene_to_expression_edges", "original_subject": "NCBIGene:534965", "original_object": "UBERON:0001158"}
{"subject": "NCBIGene:534965", "predicate": "biolink:expressed_in", "object": "UBERON:0001158", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "knowledge_assertion", "agent_type": "not_provided", "id": "uuid:4040815b-c4a9-11f0-abf2-8f8ce19e938d", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "provided_by": "bgee_gene_to_expression_edges", "original_subject": "NCBIGene:534965", "original_object": "UBERON:0001158"}
{"subject": "NCBIGene:388", "predicate": "biolink:regulates", "object": "NCBIGene:1058", "primary_knowledge_source": "infores:lincs", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "NCBIGene:388", "original_object": "NCBIGene:1058"}
{"subject": "NCBIGene:388", "predicate": "biolink:regulates", "object": "NCBIGene:1058", "primary_knowledge_source": "infores:lincs", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "NCBIGene:388", "original_object": "NCBIGene:1058"}
{"subject": "NCBIGene:388", "predicate": "biolink:regulates", "object": "NCBIGene:1058", "primary_knowledge_source": "infores:lincs", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "NCBIGene:388", "original_object": "NCBIGene:1058"}
{"subject": "NCBIGene:388", "predicate": "biolink:regulates", "object": "NCBIGene:1058", "primary_knowledge_source": "infores:lincs", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "NCBIGene:388", "original_object": "NCBIGene:1058"}
{"subject": "NCBIGene:4998", "predicate": "biolink:affects", "object": "NCBIGene:80725", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5747948"], "tmkp_confidence_score": 0.95192146, "sentences": "Upregulated molecules include ANLN, BLM, BNIP3, BRIP1, BUB1, C5orf22, CA9, CCDC6, CDC25A, CDC45, CENPU, CEP72, CHRNA5, CKS2, DDT, DGKD, DMBT1, E2f, E2F1, EIF4EBP1 (alias 4EBP1), ESRP2, EXOSC4, GPR26, GSDMB, HN1, LLGL2, KNL1 (CASC5), MYCN, NUSAP1, ORC1, PFKP, RAD51, RAD54L, RAP1GAP, RASGRF1, RDH10, RRAGD, RPL13A (SNORD34, SNORD35A), RPLP2 (SNORA52), RPS2 (SNORA10), RSP3 (SNORD15A), S100A7, S100A7A, S100A9, SGO1 (SGOL1), SLC25A19, SPRY4, SRCIN1, STK3, TBX20, TRIB3, TTK, UBE2S, and XRCC2.|NA", "tmkp_ids": ["tmkp:11b4e21e75c5fceb42be5a2ecdf229087a67c91b0f3f0267462950ebf0b08339"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "UniProtKB:Q13415", "original_object": "UniProtKB:Q9C0H9"}
{"subject": "NCBIGene:4998", "predicate": "biolink:affects", "object": "NCBIGene:80725", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5747948"], "tmkp_confidence_score": 0.95192146, "sentences": "Upregulated molecules include ANLN, BLM, BNIP3, BRIP1, BUB1, C5orf22, CA9, CCDC6, CDC25A, CDC45, CENPU, CEP72, CHRNA5, CKS2, DDT, DGKD, DMBT1, E2f, E2F1, EIF4EBP1 (alias 4EBP1), ESRP2, EXOSC4, GPR26, GSDMB, HN1, LLGL2, KNL1 (CASC5), MYCN, NUSAP1, ORC1, PFKP, RAD51, RAD54L, RAP1GAP, RASGRF1, RDH10, RRAGD, RPL13A (SNORD34, SNORD35A), RPLP2 (SNORA52), RPS2 (SNORA10), RSP3 (SNORD15A), S100A7, S100A7A, S100A9, SGO1 (SGOL1), SLC25A19, SPRY4, SRCIN1, STK3, TBX20, TRIB3, TTK, UBE2S, and XRCC2.|NA", "tmkp_ids": ["tmkp:11b4e21e75c5fceb42be5a2ecdf229087a67c91b0f3f0267462950ebf0b08339"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "UniProtKB:Q13415", "original_object": "UniProtKB:Q9C0H9"}
{"subject": "NCBIGene:4998", "predicate": "biolink:affects", "object": "NCBIGene:80725", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5747948"], "tmkp_confidence_score": 0.95192146, "sentences": "Upregulated molecules include ANLN, BLM, BNIP3, BRIP1, BUB1, C5orf22, CA9, CCDC6, CDC25A, CDC45, CENPU, CEP72, CHRNA5, CKS2, DDT, DGKD, DMBT1, E2f, E2F1, EIF4EBP1 (alias 4EBP1), ESRP2, EXOSC4, GPR26, GSDMB, HN1, LLGL2, KNL1 (CASC5), MYCN, NUSAP1, ORC1, PFKP, RAD51, RAD54L, RAP1GAP, RASGRF1, RDH10, RRAGD, RPL13A (SNORD34, SNORD35A), RPLP2 (SNORA52), RPS2 (SNORA10), RSP3 (SNORD15A), S100A7, S100A7A, S100A9, SGO1 (SGOL1), SLC25A19, SPRY4, SRCIN1, STK3, TBX20, TRIB3, TTK, UBE2S, and XRCC2.|NA", "tmkp_ids": ["tmkp:11b4e21e75c5fceb42be5a2ecdf229087a67c91b0f3f0267462950ebf0b08339"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "UniProtKB:Q13415", "original_object": "UniProtKB:Q9C0H9"}
{"subject": "NCBIGene:4998", "predicate": "biolink:affects", "object": "NCBIGene:80725", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5747948"], "tmkp_confidence_score": 0.95192146, "sentences": "Upregulated molecules include ANLN, BLM, BNIP3, BRIP1, BUB1, C5orf22, CA9, CCDC6, CDC25A, CDC45, CENPU, CEP72, CHRNA5, CKS2, DDT, DGKD, DMBT1, E2f, E2F1, EIF4EBP1 (alias 4EBP1), ESRP2, EXOSC4, GPR26, GSDMB, HN1, LLGL2, KNL1 (CASC5), MYCN, NUSAP1, ORC1, PFKP, RAD51, RAD54L, RAP1GAP, RASGRF1, RDH10, RRAGD, RPL13A (SNORD34, SNORD35A), RPLP2 (SNORA52), RPS2 (SNORA10), RSP3 (SNORD15A), S100A7, S100A7A, S100A9, SGO1 (SGOL1), SLC25A19, SPRY4, SRCIN1, STK3, TBX20, TRIB3, TTK, UBE2S, and XRCC2.|NA", "tmkp_ids": ["tmkp:11b4e21e75c5fceb42be5a2ecdf229087a67c91b0f3f0267462950ebf0b08339"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "increased", "original_subject": "UniProtKB:Q13415", "original_object": "UniProtKB:Q9C0H9"}
{"subject": "PANTHER.FAMILY:PTHR22884:SF473", "predicate": "biolink:actively_involved_in", "object": "GO:2001141", "primary_knowledge_source": "infores:panther", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR22884:SF473", "original_object": "GO:2001141"}
{"subject": "PUBCHEM.COMPOUND:118207377", "predicate": "biolink:related_to", "object": "NCBIGene:24410", "ligand": "PUBCHEM.COMPOUND:118207377", "protein": "UniProtKB:Q00960", "affinity_parameter": "pKi", "supporting_affinities": [8.8], "pubchem_assay_ids": ["PUBCHEM.AID:aid1802064"], "patent_ids": ["PATENT:US9221796"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 8.8, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:118207377", "original_object": "UniProtKB:Q00960"}
{"subject": "PUBCHEM.COMPOUND:118207377", "predicate": "biolink:related_to", "object": "NCBIGene:24410", "ligand": "PUBCHEM.COMPOUND:118207377", "protein": "UniProtKB:Q00960", "affinity_parameter": "pKi", "supporting_affinities": [8.8], "pubchem_assay_ids": ["PUBCHEM.AID:aid1802064"], "patent_ids": ["PATENT:US9221796"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 8.8, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:118207377", "original_object": "UniProtKB:Q00960"}
{"subject": "NCBIGene:24141", "predicate": "biolink:subclass_of", "object": "PR:000036194", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:Q9UJQ1", "original_object": "PR:000036194"}
{"subject": "NCBIGene:24141", "predicate": "biolink:subclass_of", "object": "PR:000036194", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:Q9UJQ1", "original_object": "PR:000036194"}
{"subject": "CHEBI:74947", "predicate": "biolink:causes", "object": "HP:0001288", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01041", "original_object": "UMLS:C0575081"}
{"subject": "CHEBI:74947", "predicate": "biolink:causes", "object": "HP:0001288", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01041", "original_object": "UMLS:C0575081"}
{"subject": "HP:0000682", "predicate": "biolink:subclass_of", "object": "HP:0000118", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000682", "original_object": "HP:0000118"}
{"object": "REACT:R-HSA-69473", "predicate": "biolink:occurs_in", "subject": "REACT:R-HSA-75035", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-HSA-69473", "original_subject": "REACT:R-HSA-75035"}
{"subject": "PANTHER.FAMILY:PTHR11706:SF52", "predicate": "biolink:located_in", "object": "GO:0098852", "primary_knowledge_source": "infores:panther", "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "PANTHER.FAMILY:PTHR11706:SF52", "original_object": "GO:0098852"}
{"subject": "UBERON:0000178", "predicate": "biolink:regulates", "object": "NCBIGene:26266", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UBERON:0000178", "original_object": "NCBIGene:26266", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "downregulated", "qualified_predicate": "biolink:causes"}
{"subject": "UBERON:0000178", "predicate": "biolink:regulates", "object": "NCBIGene:26266", "primary_knowledge_source": "infores:bgee", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "UBERON:0000178", "original_object": "NCBIGene:26266", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "downregulated", "qualified_predicate": "biolink:causes"}
{"subject": "GO:0060856", "predicate": "biolink:in_taxon", "object": "NCBITaxon:33213", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060856", "original_object": "NCBITaxon:33213"}
{"subject": "CHEBI:43401", "predicate": "biolink:subclass_of", "object": "CHEBI:24532", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:43401", "original_object": "CHEBI:24532"}
{"subject": "CL:0003027", "predicate": "biolink:subclass_of", "object": "UBERON:0001062", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0003027", "original_object": "UBERON:0001062"}
{"subject": "GO:1905058", "predicate": "biolink:in_taxon", "object": "NCBITaxon:131567", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1905058", "original_object": "NCBITaxon:131567"}
{"subject": "MONDO:0002334", "predicate": "biolink:related_to", "object": "NCBIGene:5295", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["DisGeNET"], "original_subject": "DOID:2531", "original_object": "NCBIGene:5295"}
{"subject": "MONDO:0002334", "predicate": "biolink:related_to", "object": "NCBIGene:5295", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["DisGeNET"], "original_subject": "DOID:2531", "original_object": "NCBIGene:5295"}
{"subject": "MONDO:0014527", "predicate": "biolink:has_phenotype", "object": "MONDO:0020378", "primary_knowledge_source": "infores:omim", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:hpo-annotations"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "id": "uuid:5e98a2fa-c3f3-11f0-a059-7ced8d3cc01b", "category": ["biolink:DiseaseToPhenotypicFeatureAssociation", "biolink:FrequencyQuantifier", "biolink:EntityToPhenotypicFeatureAssociationMixin", "biolink:DiseaseToEntityAssociationMixin", "biolink:Association", "biolink:Entity", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin", "biolink:RelationshipQuantifier"], "has_evidence": ["ECO:0000304"], "provided_by": "hpoa_disease_to_phenotype_edges", "original_subject": "MONDO:0014527", "original_object": "HP:0007787"}
{"subject": "CHEBI:43755", "predicate": "biolink:has_adverse_event", "object": "MONDO:0005609", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 30.654, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1587", "original_object": "MEDDRA:10019974"}
{"subject": "CHEBI:43755", "predicate": "biolink:has_adverse_event", "object": "MONDO:0005609", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 30.654, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1587", "original_object": "MEDDRA:10019974"}
{"subject": "UBERON:4200084", "predicate": "biolink:subclass_of", "object": "UBERON:0004375", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:4200084", "original_object": "UBERON:0004375"}
{"subject": "CAID:CA500026", "predicate": "biolink:has_phenotype", "object": "MONDO:0005306", "primary_knowledge_source": "infores:gwas-catalog", "publications": ["PMID:26974007"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "p_value": 1e-31, "original_subject": "DBSNP:rs141992399", "original_object": "EFO:0003898"}
{"subject": "CAID:CA15306787", "predicate": "biolink:has_phenotype", "object": "EFO:0801923", "primary_knowledge_source": "infores:gwas-catalog", "publications": ["PMID:34648354"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "p_value": 2e-19, "original_subject": "DBSNP:rs781658-A", "original_object": "EFO:0801923"}
{"subject": "CHEBI:215155", "predicate": "biolink:subclass_of", "object": "CHEBI:35701", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:215155", "original_object": "CHEBI:35701"}
{"subject": "NCBIGene:6331", "predicate": "biolink:has_phenotype", "object": "MONDO:0000190", "primary_knowledge_source": "infores:hpo-annotations", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "logical_entailment", "agent_type": "automated_agent", "id": "uuid:52f863d9-c3f3-11f0-a059-7ced8d3cc01b", "category": ["biolink:GeneToPhenotypicFeatureAssociation", "biolink:EntityToPhenotypicFeatureAssociationMixin", "biolink:GeneToEntityAssociationMixin", "biolink:GeneToDiseaseOrPhenotypicFeatureAssociation", "biolink:Association", "biolink:Entity", "biolink:FrequencyQuantifier", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin", "biolink:RelationshipQuantifier"], "disease_context_qualifier": "OMIM:603829", "provided_by": "hpoa_gene_to_phenotype_edges", "original_subject": "HGNC:10593", "original_object": "HP:0001663"}
{"subject": "NCBIGene:6331", "predicate": "biolink:has_phenotype", "object": "MONDO:0000190", "primary_knowledge_source": "infores:hpo-annotations", "aggregator_knowledge_source": ["infores:monarchinitiative"], "knowledge_level": "logical_entailment", "agent_type": "automated_agent", "id": "uuid:52f863d9-c3f3-11f0-a059-7ced8d3cc01b", "category": ["biolink:GeneToPhenotypicFeatureAssociation", "biolink:EntityToPhenotypicFeatureAssociationMixin", "biolink:GeneToEntityAssociationMixin", "biolink:GeneToDiseaseOrPhenotypicFeatureAssociation", "biolink:Association", "biolink:Entity", "biolink:FrequencyQuantifier", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin", "biolink:RelationshipQuantifier"], "disease_context_qualifier": "OMIM:603829", "provided_by": "hpoa_gene_to_phenotype_edges", "original_subject": "HGNC:10593", "original_object": "HP:0001663"}
{"subject": "CAID:CA7709631", "predicate": "biolink:is_synonymous_variant_of", "object": "NCBIGene:57538", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "synonymous_variant", "original_subject": "CAID:CA7709631", "original_object": "ENSEMBL:ENSG00000136383"}
{"subject": "CAID:CA7709631", "predicate": "biolink:is_synonymous_variant_of", "object": "NCBIGene:57538", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "synonymous_variant", "original_subject": "CAID:CA7709631", "original_object": "ENSEMBL:ENSG00000136383"}
{"subject": "NCBIGene:8483", "predicate": "biolink:interacts_with", "object": "NCBIGene:1299", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "ENSEMBL:ENSP00000261883", "original_object": "ENSEMBL:ENSP00000496793"}
{"subject": "NCBIGene:8483", "predicate": "biolink:interacts_with", "object": "NCBIGene:1299", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "ENSEMBL:ENSP00000261883", "original_object": "ENSEMBL:ENSP00000496793"}
{"subject": "NCBIGene:8483", "predicate": "biolink:interacts_with", "object": "NCBIGene:1299", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "ENSEMBL:ENSP00000261883", "original_object": "ENSEMBL:ENSP00000496793"}
{"subject": "NCBIGene:8483", "predicate": "biolink:interacts_with", "object": "NCBIGene:1299", "primary_knowledge_source": "infores:string", "species_context_qualifier": "NCBITaxon:9606", "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "ENSEMBL:ENSP00000261883", "original_object": "ENSEMBL:ENSP00000496793"}
{"subject": "MONDO:0001244", "predicate": "biolink:subclass_of", "object": "HP:0032245", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0011892", "original_object": "HP:0032245"}
{"subject": "CHEBI:37941", "predicate": "biolink:regulates", "object": "NCBIGene:6241", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:60606", "original_object": "HGNC:10452", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "CHEBI:37941", "predicate": "biolink:regulates", "object": "NCBIGene:6241", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:60606", "original_object": "HGNC:10452", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "CHEBI:37941", "predicate": "biolink:regulates", "object": "NCBIGene:6241", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:60606", "original_object": "HGNC:10452", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "CHEBI:37941", "predicate": "biolink:regulates", "object": "NCBIGene:6241", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:60606", "original_object": "HGNC:10452", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "NCBIGene:6678", "predicate": "biolink:genetically_associated_with", "object": "MONDO:0005010", "primary_knowledge_source": "infores:ctd", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "prediction", "agent_type": "manual_agent", "original_subject": "HGNC:11219", "original_object": "DOID:3393"}
{"subject": "NCBIGene:6678", "predicate": "biolink:genetically_associated_with", "object": "MONDO:0005010", "primary_knowledge_source": "infores:ctd", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "prediction", "agent_type": "manual_agent", "original_subject": "HGNC:11219", "original_object": "DOID:3393"}
{"subject": "GO:0031829", "predicate": "biolink:subclass_of", "object": "GO:0005515", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0031829", "original_object": "GO:0005515"}
{"subject": "CHEBI:41500", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0008322", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6168010"], "tmkp_confidence_score": 1.044830170792626, "sentences": "Our first therapeutic approach to treat PSACH in our MT-COMP mouse was administration of ER stress reducing, drugs valproate, lithium and phenylbutyric acid from birth until 4 weeks after birth.|NA", "tmkp_ids": ["tmkp:a8823fbb4e8b65e6e3c7935dbbeec975cbcdf00af0948ee62768e31464156d40"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB06819", "original_object": "MONDO:0008322"}
{"subject": "CHEBI:41500", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0008322", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6168010"], "tmkp_confidence_score": 1.044830170792626, "sentences": "Our first therapeutic approach to treat PSACH in our MT-COMP mouse was administration of ER stress reducing, drugs valproate, lithium and phenylbutyric acid from birth until 4 weeks after birth.|NA", "tmkp_ids": ["tmkp:a8823fbb4e8b65e6e3c7935dbbeec975cbcdf00af0948ee62768e31464156d40"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB06819", "original_object": "MONDO:0008322"}
{"subject": "CHEBI:78540", "predicate": "biolink:affects", "object": "NCBIGene:3717", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMID:27856658"], "tmkp_confidence_score": 0.999366, "sentences": "This review concentrates on new developments, mainly covering biologic agents with an IL-17 inhibitor (secukinumab) and an anti-IL-23 agent (ustekinumab), but also synthetic drugs, including a novel phosphodiesterase-4 inhibitor (apremilast) and a Janus kinase inhibitor (tofacitinib) that blocks mainly Jak3 and Jak1 and, to a lesser extent, Jak2.|NA", "tmkp_ids": ["tmkp:1e85fbba595f85ce42bdf2c3f703e33e57ac217519b2cf6bf057ba80107394ab"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "decreased", "original_subject": "DRUGBANK:DB05676", "original_object": "UniProtKB:O60674"}
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{"subject": "UniProtKB:Q8BX79-1", "predicate": "biolink:subclass_of", "object": "NCBIGene:338346", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:Q8BX79-1", "original_object": "PR:Q8BX79"}
{"subject": "CHEBI:19775", "predicate": "biolink:related_to", "object": "CHEBI:18386", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:19775", "original_object": "CHEBI:18386"}
{"subject": "MONDO:0006955", "predicate": "biolink:related_to", "object": "UBERON:0000915", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0006955", "original_object": "UBERON:0000915"}
{"subject": "NCBIGene:856657", "predicate": "biolink:expressed_in", "object": "GO:0031417", "primary_knowledge_source": "infores:sgd", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:agrkb"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:10504710"], "id": "uuid:702efc89-c4a8-11f0-abf2-8f8ce19e938d", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "provided_by": "alliance_gene_to_expression_edges", "original_subject": "SGD:S000000779", "original_object": "GO:0031417"}
{"subject": "NCBIGene:856657", "predicate": "biolink:expressed_in", "object": "GO:0031417", "primary_knowledge_source": "infores:sgd", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:agrkb"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:10504710"], "id": "uuid:702efc89-c4a8-11f0-abf2-8f8ce19e938d", "category": ["biolink:GeneToExpressionSiteAssociation", "biolink:Association", "biolink:Entity"], "provided_by": "alliance_gene_to_expression_edges", "original_subject": "SGD:S000000779", "original_object": "GO:0031417"}
{"subject": "REACT:R-MMU-2046089", "predicate": "biolink:has_output", "object": "CHEBI:57540", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-MMU-2046089", "original_object": "CHEBI:57540"}
{"subject": "CHEBI:26711", "predicate": "biolink:subclass_of", "object": "CHEBI:51958", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:26711", "original_object": "CHEBI:51958"}
{"subject": "REACT:R-SPO-9845576", "predicate": "biolink:occurs_in", "object": "GO:0005829", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SPO-9845576", "original_object": "GO:0005829"}
{"subject": "NCIT:C56911", "predicate": "biolink:subclass_of", "object": "EFO:0009658", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C56911", "original_object": "NCIT:C41331"}
{"subject": "CHEBI:36009", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0005267", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9113147", "PMC:4431415"], "tmkp_confidence_score": 0.5388464144180738, "sentences": "Some oils are also nutritionally important due to their requirement in a healthy diet including long-chain omega-3 and omega-6 fatty acids which have functions that help prevent heart disease and stroke (R?os-Covi?n et al.,).|NA|Furthermore, EPUFAs such as omega-3 and omega-6 fatty acids have important effects on the body, particularly relevant to enhancing appropriate pre- and postnatal development (mainly of the central and peripheral nervous systems), lowering cholesterol and triglyceride levels, reducing acute and chronic inflammation, treating patients with neurodegenerative disorders, contributing to blood pressure regulation, and reducing the odds of developing cancer, heart disease, and stroke.|NA", "tmkp_ids": ["tmkp:37dfbae222f18b02ab7dbcef8a1e2e484d06b585634ad7e8aa9bea767d72670f", "tmkp:b60a7e5818bb5934267b44b245e3c129299efee36a60f966a07c15c1eceaf367"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB13168", "original_object": "MONDO:0005267"}
{"subject": "MONDO:0015571", "predicate": "biolink:has_phenotype", "object": "HP:0001252", "primary_knowledge_source": "infores:orphanet", "aggregator_knowledge_source": ["infores:monarchinitiative", "infores:hpo-annotations"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "id": "uuid:68221794-c3f3-11f0-a059-7ced8d3cc01b", "category": ["biolink:DiseaseToPhenotypicFeatureAssociation", "biolink:FrequencyQuantifier", "biolink:EntityToPhenotypicFeatureAssociationMixin", "biolink:DiseaseToEntityAssociationMixin", "biolink:Association", "biolink:Entity", "biolink:EntityToFeatureOrDiseaseQualifiersMixin", "biolink:FrequencyQualifierMixin", "biolink:RelationshipQuantifier"], "has_evidence": ["ECO:0000304"], "frequency_qualifier": "HP:0040282", "provided_by": "hpoa_disease_to_phenotype_edges", "original_subject": "MONDO:0015571", "original_object": "HP:0001252"}
{"subject": "NCBIGene:6839", "predicate": "biolink:correlated_with", "object": "NCBIGene:51310", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["ERC"], "original_subject": "NCBIGene:6839", "original_object": "NCBIGene:51310"}
{"subject": "NCBIGene:6839", "predicate": "biolink:correlated_with", "object": "NCBIGene:51310", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["ERC"], "original_subject": "NCBIGene:6839", "original_object": "NCBIGene:51310"}
{"subject": "NCBIGene:6839", "predicate": "biolink:correlated_with", "object": "NCBIGene:51310", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["ERC"], "original_subject": "NCBIGene:6839", "original_object": "NCBIGene:51310"}
{"subject": "NCBIGene:6839", "predicate": "biolink:correlated_with", "object": "NCBIGene:51310", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["ERC"], "original_subject": "NCBIGene:6839", "original_object": "NCBIGene:51310"}
{"subject": "UBERON:0010062", "predicate": "biolink:develops_from", "object": "UBERON:0010020", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010062", "original_object": "UBERON:0010020"}
{"subject": "GO:0034467", "predicate": "biolink:subclass_of", "object": "GO:0031983", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0034467", "original_object": "GO:0031983"}
{"subject": "NCBIGene:84899", "predicate": "biolink:actively_involved_in", "object": "GO:0030968", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:Q5T4D3", "original_object": "GO:0030968"}
{"subject": "NCBIGene:84899", "predicate": "biolink:actively_involved_in", "object": "GO:0030968", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:Q5T4D3", "original_object": "GO:0030968"}
{"subject": "CHEBI:8389", "predicate": "biolink:has_adverse_event", "object": "MONDO:0013600", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 72.091, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4855", "original_object": "MEDDRA:10022437"}
{"subject": "CHEBI:144421", "predicate": "biolink:subclass_of", "object": "CHEBI:5975", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:144421", "original_object": "CHEBI:5975"}
{"subject": "NCBIGene:3475", "predicate": "biolink:active_in", "object": "GO:0005634", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:O00458", "original_object": "GO:0005634"}
{"subject": "NCBIGene:3475", "predicate": "biolink:active_in", "object": "GO:0005634", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:O00458", "original_object": "GO:0005634"}
{"object": "UBERON:0019290", "predicate": "biolink:has_part", "subject": "UBERON:0004069", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0019290", "original_subject": "UBERON:0004069"}
{"subject": "MONDO:0008487", "predicate": "biolink:regulates", "object": "NCBIGene:84266", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["STARGEO"], "original_subject": "DOID:11612", "original_object": "NCBIGene:84266", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "downregulated", "qualified_predicate": "biolink:causes"}
{"subject": "MONDO:0008487", "predicate": "biolink:regulates", "object": "NCBIGene:84266", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["STARGEO"], "original_subject": "DOID:11612", "original_object": "NCBIGene:84266", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "downregulated", "qualified_predicate": "biolink:causes"}
{"object": "GO:0098899", "predicate": "biolink:has_part", "subject": "GO:0097444", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0098899", "original_subject": "GO:0097444"}
{"subject": "CAID:CA114360", "predicate": "biolink:causes", "object": "MONDO:0009861", "primary_knowledge_source": "infores:clingen", "ASSERTION": "Pathogenic", "APPLIED_EVIDENCE_CODES_MET": "PM3, PP4_Moderate, PM2, PS3", "APPLIED_EVIDENCE_CODES_NOT_MET": "PVS1", "SUMMARY": "PAH-specific ACMG/AMP criteria applied: PM2: gnomAD MAF=0.00002; PP4_Moderate: Seen in PKU patients. BH4 disorders ruled out. (PMID:2574002); PS3: <3% (PMID:9450897). PM3: Detected in trans with known pathogenic variants. In summary this variant meets criteria to be classified as pathogenic for phenylketonuria in an autosomal recessive manner based on the ACMG/AMP criteria applied as specified by the PAH Expert Panel: (PM2, PM3, PP4_Moderate, PS3). Updated to reflect new PVS1 recommendations.", "publications": ["PMID:2574002", "PMID:2574002", "PMID:9450897"], "EXPERT_PANEL": "Phenylketonuria VCEP", "EVIDENCE_REPO_LINK": "https://erepo.genome.network/evrepo/ui/classification/CA114360/MONDO:0009861/006", "APPROVAL_DATA": "2019-03-23", "PUBLISHED_DATE": "2019-05-10", "MODE_OF_INHERITANCE": "Autosomal recessive inheritance", "HPO_FOR_MODE_OF_INHERITANCE": "HP:0000007", "DIRECTION": "Supports", "original_subject": "CAID:CA114360", "original_object": "MONDO:0009861"}
{"subject": "REACT:R-BTA-9627104", "predicate": "biolink:has_input", "object": "UniProtKB:G3MWG5", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-BTA-9627104", "original_object": "UniProtKB:G3MWG5"}
{"subject": "GO:0043370", "predicate": "biolink:precedes", "object": "GO:0043367", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0043370", "original_object": "GO:0043367"}
{"object": "REACT:R-HSA-5624239", "predicate": "biolink:occurs_in", "subject": "REACT:R-HSA-428585", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "REACT:R-HSA-5624239", "original_subject": "REACT:R-HSA-428585"}
{"subject": "CAID:CA6344374", "predicate": "biolink:related_to", "object": "NCBIGene:64221", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "disruptive_inframe_deletion", "original_subject": "CAID:CA6344374", "original_object": "ENSEMBL:ENSG00000154134"}
{"subject": "CAID:CA6344374", "predicate": "biolink:related_to", "object": "NCBIGene:64221", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "disruptive_inframe_deletion", "original_subject": "CAID:CA6344374", "original_object": "ENSEMBL:ENSG00000154134"}
{"subject": "UMLS:C4331232", "predicate": "biolink:related_to", "object": "UMLS:C1402294", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C131501", "original_object": "NCIT:C40558"}
{"subject": "CHEBI:167638", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0271149", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1531", "original_object": "UMLS:C0271149"}
{"subject": "CHEBI:167638", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0271149", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1531", "original_object": "UMLS:C0271149"}
{"object": "MONDO:0026729", "predicate": "biolink:gene_associated_with_condition", "subject": "NCBIGene:84061", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0026729", "original_subject": "HGNC:28880"}
{"object": "MONDO:0026729", "predicate": "biolink:gene_associated_with_condition", "subject": "NCBIGene:84061", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0026729", "original_subject": "HGNC:28880"}
{"object": "HGNC.FAMILY:590", "predicate": "biolink:has_part", "subject": "NCBIGene:8778", "primary_knowledge_source": "infores:hgnc", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:10343116"], "original_object": "HGNC.FAMILY:590", "original_subject": "HGNC:10874"}
{"subject": "CHEBI:43522", "predicate": "biolink:subclass_of", "object": "CHEBI:26151", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:43522", "original_object": "CHEBI:26151"}
{"subject": "CAID:CA9973796", "predicate": "biolink:is_missense_variant_of", "object": "NCBIGene:198437", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "missense_variant", "original_subject": "CAID:CA9973796", "original_object": "ENSEMBL:ENSG00000171695"}
{"subject": "CAID:CA9973796", "predicate": "biolink:is_missense_variant_of", "object": "NCBIGene:198437", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "missense_variant", "original_subject": "CAID:CA9973796", "original_object": "ENSEMBL:ENSG00000171695"}
{"subject": "REACT:R-CFA-9756138", "predicate": "biolink:has_output", "object": "CHEBI:180932", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-CFA-9756138", "original_object": "CHEBI:180932"}
{"subject": "REACT:R-SSC-9728150", "predicate": "biolink:has_input", "object": "NCBIGene:100286743", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SSC-9728150", "original_object": "UniProtKB:A0A5G2R5M2"}
{"subject": "CAID:CA700475", "predicate": "biolink:is_frameshift_variant_of", "object": "NCBIGene:10256", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "frameshift_variant", "original_subject": "CAID:CA700475", "original_object": "ENSEMBL:ENSG00000142675"}
{"subject": "CAID:CA700475", "predicate": "biolink:is_frameshift_variant_of", "object": "NCBIGene:10256", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "frameshift_variant", "original_subject": "CAID:CA700475", "original_object": "ENSEMBL:ENSG00000142675"}
{"subject": "CHEBI:50729", "predicate": "biolink:contributes_to", "object": "HP:0002013", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:10597740", "PMID:11851027", "PMID:15333686"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008942", "original_object": "MESH:D014839"}
{"subject": "CHEBI:50729", "predicate": "biolink:contributes_to", "object": "HP:0002013", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:10597740", "PMID:11851027", "PMID:15333686"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008942", "original_object": "MESH:D014839"}
{"subject": "CHEBI:3207", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0002783", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:7708268", "PMC:7708268", "PMC:7708268"], "tmkp_confidence_score": 0.9865026, "sentences": "Budesonide/formoterol significantly reduces the frequency of these events versus formoterol alone, without an associated increase in the rate of LRTI and pneumonia.|NA|Finally, we assess whether therapy with budesonide/formoterol versus formoterol alone can reduce the frequency of, and outcomes associated with, COPD symptom-related attacks, and whether this addition of an inhaled corticosteroid (ICS) to a long-acting ?2-agonist (LABA) is associated with an increased incidence of lower respiratory tract infections (LRTI) and pneumonia.|NA|In addition to highlighting the incidence and importance of COPD symptom-related attacks, our analysis also showed that adding budesonide to formoterol significantly reduces the frequency of these attacks versus formoterol alone, without the increased risk of LRTI or pneumonia.|NA", "tmkp_ids": ["tmkp:8a00e41fc8ab25edc0b73ee2df14171a9a85d036a97261e177e600e8c936111c", "tmkp:63ffc9358890913b843d836527a07b7f8bb7f8112483f4184271ea6dec6b7444", "tmkp:02732dba589fa52d1e62ebfe15ab2ce76860307bd5e97a1287347fc86611ab98"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB01222", "original_object": "HP:0002783"}
{"subject": "CHEBI:3207", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0002783", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:7708268", "PMC:7708268", "PMC:7708268"], "tmkp_confidence_score": 0.9865026, "sentences": "Budesonide/formoterol significantly reduces the frequency of these events versus formoterol alone, without an associated increase in the rate of LRTI and pneumonia.|NA|Finally, we assess whether therapy with budesonide/formoterol versus formoterol alone can reduce the frequency of, and outcomes associated with, COPD symptom-related attacks, and whether this addition of an inhaled corticosteroid (ICS) to a long-acting ?2-agonist (LABA) is associated with an increased incidence of lower respiratory tract infections (LRTI) and pneumonia.|NA|In addition to highlighting the incidence and importance of COPD symptom-related attacks, our analysis also showed that adding budesonide to formoterol significantly reduces the frequency of these attacks versus formoterol alone, without the increased risk of LRTI or pneumonia.|NA", "tmkp_ids": ["tmkp:8a00e41fc8ab25edc0b73ee2df14171a9a85d036a97261e177e600e8c936111c", "tmkp:63ffc9358890913b843d836527a07b7f8bb7f8112483f4184271ea6dec6b7444", "tmkp:02732dba589fa52d1e62ebfe15ab2ce76860307bd5e97a1287347fc86611ab98"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB01222", "original_object": "HP:0002783"}
{"subject": "CHEBI:34764", "predicate": "biolink:has_adverse_event", "object": "HP:0001155", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 547.154, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1198", "original_object": "MEDDRA:10061194"}
{"subject": "CHEBI:34764", "predicate": "biolink:has_adverse_event", "object": "HP:0001155", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 547.154, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1198", "original_object": "MEDDRA:10061194"}
{"subject": "NCBIGene:6927", "predicate": "biolink:genetically_associated_with", "object": "HP:0012051", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:11621", "original_object": "UMLS:C0271710"}
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{"subject": "PUBCHEM.COMPOUND:44422696", "predicate": "biolink:related_to", "object": "NCBIGene:1132", "ligand": "PUBCHEM.COMPOUND:44422696", "protein": "UniProtKB:P08173", "affinity_parameter": "pKi", "supporting_affinities": [4.34], "publications": ["PMID:18077164"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 4.34, "primary_knowledge_source": "infores:bindingdb", "original_subject": "PUBCHEM.COMPOUND:44422696", "original_object": "UniProtKB:P08173"}
{"subject": "HP:0002098", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002046", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00822_MESH_D000437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002098", "original_object": "MESH:D000437"}
{"subject": "NCBIGene:213", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0010604", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5269444", "PMC:5269444", "PMC:7467451", "PMC:7467451", "PMC:8362221"], "tmkp_confidence_score": 0.7510764686879398, "sentences": "These results demonstrate improved correction of hemophilia B using AAV vectors pre-incubated with HSA, and also suggest possible utilization of this formulation to increase efficacy at lower vector doses for the treatment of hemophilia and other diseases.|NA|Improved phenotypic correction of hemophilia B using human albumin to enhance AAV vector transduction|NA|An extended half-life fusion protein linking recombinant FIX (rFIX) with human albumin (rIX-FP) has been developed for the treatment of patients with haemophilia B and is indicated for dosing up to every 14?days.|NA|This study looked at the use of an extended half-life fusion protein linking recombinant FIX (rFIX) with human albumin (rIX-FP), which was designed to allow longer dosing intervals, in patients with haemophilia B in Italy, Belgium and the UK, and compared this with the patients? previous FIX product.|NA|The short half?life of coagulation factor IX (FIX) for haemophilia B (HB) therapy has been prolonged through fusion with human serum albumin (HSA), which drives the neonatal Fc receptor (FcRn)?mediated recycling of the chimera.|NA", "tmkp_ids": ["tmkp:ea6077357b87d83e75591a3f05a9b23dfbd36bd2bef7d5d6b1ed1b6f7f413490", "tmkp:c5fe9040a43a41e353ab8e1292a19f77db8d07a1965b97337c673d0bf92e545d", "tmkp:6d51739a0b3e8896689128e28e893c10dbce882dc01c65e0b1eb8384f65239aa", "tmkp:808d4496d401416444223e8287801d6655880b5113d86b2dae8910afa8dde67c", "tmkp:aaea7629bde1e50035ac706ae62a60850a01f58825ec1e574a59f55a85c95925"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00062", "original_object": "MONDO:0010604"}
{"subject": "CHEBI:25944", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005093", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:15858460", "PMID:11665844"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010575", "original_object": "MESH:D012871"}
{"subject": "UNII:9JD9B4S53T", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "MONDO:0016262", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9180633", "PMC:9180633", "PMC:9180633", "PMC:9180633", "PMC:9180633"], "tmkp_confidence_score": 0.99948324, "sentences": "In uLMS cells, DAPT and MK-0752 decreased Notch signaling in a dose- and time-dependent manner.|NA|DAPT and MK-0752 Decrease uLMS Cell Viability|NA|Taken together, our findings demonstrate that DAPT is more effective than MK-0752 at reducing Notch signaling activity in uLMS cells, but neither GSI decreases uLMS cell proliferation or invasion, which are required for tumor progression.|NA|Exposure of SK-UT-1B and SK-LMS-1 to DAPT and MK-0752 decreased expression of HES1 and decreased uLMS cell viability in a dose- and time-dependent manner that was unique to each GSI.|NA|MK-0752, which is orally tolerated, should be investigated in 3D in vitro and in vivo models, either alone or in combination with other cytotoxic agents, to further assess efficacy as a potential therapeutic modality against uLMS.|NA", "tmkp_ids": ["tmkp:0de2a52300f83b6d5675b2a02cee3342ffd764a64aca30dcc03f9df683f8d5c2", "tmkp:8344109c65dc7c3507b03184fd603ac5810550e4c9d10a46ae01eb96055e0cde", "tmkp:8c95a620a9fb15757b97abb9d50d5962e4b9fa528d19577a5f9223259be5d136", "tmkp:481fc3bd2a5b21b43d1ff52a7a15108af83ba3d13671910a3767527119dce62a", "tmkp:0838bc6be36003f53ad506104e1c69a64a23a9ad4f07b6a79615833b66decf44"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB12852", "original_object": "HP:0002891"}
{"subject": "GO:0009532", "predicate": "biolink:in_taxon", "object": "NCBITaxon:131567", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009532", "original_object": "NCBITaxon:131567"}
{"subject": "CHEBI:91829", "predicate": "biolink:regulates", "object": "NCBIGene:55859", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:22565", "original_object": "HGNC:1036", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "CHEBI:91829", "predicate": "biolink:regulates", "object": "NCBIGene:55859", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:22565", "original_object": "HGNC:1036", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "UNII:C3574QBZ3Y", "predicate": "biolink:contributes_to", "object": "EFO:0009426", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:24503009"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C028007", "original_object": "MESH:D009336"}
{"subject": "GO:0015765", "predicate": "biolink:has_input", "object": "CHEBI:60982", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015765", "original_object": "CHEBI:60982"}
{"subject": "UNII:Q5EN532NE7", "predicate": "biolink:preventative_for_condition", "object": "GO:0090592", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01280_MESH_D054218_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C022206", "original_object": "GO:0090592"}
{"subject": "CHEBI:119915", "predicate": "biolink:causes", "object": "UMLS:C0235146", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00813", "original_object": "UMLS:C0235146"}
{"subject": "CHEBI:119915", "predicate": "biolink:causes", "object": "UMLS:C0235146", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00813", "original_object": "UMLS:C0235146"}
{"subject": "GO:0030073", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002909", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01016_MESH_D003924_1", "DB00731_MESH_D003924_1", "DB00672_MESH_D003924_1", "DB01289_MESH_D003924_1", "DB00222_MESH_D003924_1", "DB08962_MESH_D003924_1", "DB01124_MESH_D003924_1", "DB01120_MESH_D003924_1", "DB00839_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030073", "original_object": "HP:0003074"}
{"subject": "UBERON:0034876", "predicate": "biolink:develops_from", "object": "UBERON:0006240", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0034876", "original_object": "UBERON:0006240"}
{"subject": "UBERON:0009975", "predicate": "biolink:related_to", "object": "GO:0050877", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0009975", "original_object": "GO:0050877"}
{"subject": "MONDO:0002367", "predicate": "biolink:similar_to", "object": "MONDO:0005089", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["MEDLINE cooccurrence"], "original_subject": "DOID:263", "original_object": "DOID:1115"}
{"subject": "NCBIGene:1244", "predicate": "biolink:decreases_sensitivity_to", "object": "CHEBI:5163", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "9606", "publications": ["PMID:22095822"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:1244", "original_object": "MESH:D017328"}
{"subject": "NCBIGene:1244", "predicate": "biolink:decreases_sensitivity_to", "object": "CHEBI:5163", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "9606", "publications": ["PMID:22095822"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:1244", "original_object": "MESH:D017328"}
{"subject": "UBERON:0002233", "predicate": "biolink:related_to", "object": "UBERON:0002276", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002233", "original_object": "UBERON:0002276"}
{"subject": "CHEBI:102265", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0032981", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2502", "original_object": "UMLS:C0032981"}
{"subject": "CHEBI:5134", "predicate": "biolink:subclass_of", "object": "CHEBI:77166", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:74899", "original_object": "CHEBI:77166"}
{"subject": "MONDO:0100096", "predicate": "biolink:has_part", "object": "NCBIGene:59272", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "complex_context": ["S1:ACE2", "S1 trimer:ACE2:S2 trimer", "Spike trimer:ACE2", "S3:M:E:encapsidated  SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs", "S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2"], "original_subject": "DOID:0080600", "original_object": "UniProtKB:Q9BYF1"}
{"subject": "MONDO:0100096", "predicate": "biolink:has_part", "object": "NCBIGene:59272", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "complex_context": ["S1:ACE2", "S1 trimer:ACE2:S2 trimer", "Spike trimer:ACE2", "S3:M:E:encapsidated  SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs", "S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2"], "original_subject": "DOID:0080600", "original_object": "UniProtKB:Q9BYF1"}
{"subject": "CHEBI:180472", "predicate": "biolink:subclass_of", "object": "CHEBI:17996", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:180472", "original_object": "CHEBI:23114"}
{"subject": "CHEBI:3398", "predicate": "biolink:contraindicated_in", "object": "HP:0200119", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:499", "original_object": "UMLS:C0267797"}
{"subject": "REACT:R-SCE-4754181", "predicate": "biolink:has_output", "object": "CHEBI:30031", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-SCE-4754181", "original_object": "CHEBI:30031"}
{"subject": "CL:0000920", "predicate": "biolink:related_to", "object": "UBERON:0000077", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000920", "original_object": "UBERON:0000077"}
{"subject": "CHEBI:91083", "predicate": "biolink:related_to", "object": "CHEBI:17920", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:91083", "original_object": "CHEBI:17920"}
{"subject": "GO:0051958", "predicate": "biolink:has_input", "object": "CHEBI:50681", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0051958", "original_object": "CHEBI:50681"}
{"subject": "UMLS:C5555759", "predicate": "biolink:affects", "object": "UBERON:0012332", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C179547", "original_object": "NCIT:C12318"}
{"object": "MONDO:0000306", "predicate": "biolink:causes", "subject": "NCBITaxon:5552", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0000306", "original_subject": "NCBITaxon:5552"}
{"subject": "CHEBI:49662", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005178", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00328", "original_object": "DOID:8398"}
{"subject": "CHEBI:49662", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005178", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00328", "original_object": "DOID:8398"}
{"subject": "GO:0019226", "predicate": "biolink:related_to", "object": "GO:0045202", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019226", "original_object": "GO:0045202"}
{"subject": "CHEBI:8481", "predicate": "biolink:causes", "object": "UMLS:C0039971", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00782", "original_object": "UMLS:C0039971"}
{"subject": "CHEBI:8481", "predicate": "biolink:causes", "object": "UMLS:C0039971", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00782", "original_object": "UMLS:C0039971"}
{"subject": "GO:0047533", "predicate": "biolink:has_participant", "object": "CHEBI:15377", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0047533", "original_object": "CHEBI:15377"}
{"subject": "GO:0009273", "predicate": "biolink:occurs_in", "object": "NCBITaxon:139", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01112_MESH_D008193_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0009273", "original_object": "NCBITaxon:139"}
{"subject": "MONDO:0002095", "predicate": "biolink:related_to", "object": "UMLS:C1708871", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C7390", "original_object": "NCIT:C47834"}
{"subject": "REACT:R-BTA-75244", "predicate": "biolink:subclass_of", "object": "GO:0097190", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-BTA-75244", "original_object": "GO:0097190"}
{"subject": "CHEBI:17561", "predicate": "biolink:similar_to", "object": "CHEBI:15729", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00151", "original_object": "DRUGBANK:DB00129"}
{"subject": "CHEBI:51700", "predicate": "biolink:subclass_of", "object": "HP:0000118", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:51700", "original_object": "HP:0000118"}
{"subject": "CL:4033038", "predicate": "biolink:related_to", "object": "GO:0007585", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4033038", "original_object": "GO:0007585"}
{"subject": "UMLS:C2826229", "predicate": "biolink:contributes_to", "object": "HP:0003326", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6601617"], "tmkp_confidence_score": 1.2497003426605344, "sentences": "Adverse events occurring more frequently in the ado-trastuzumab emtansine group than in the lapatinib plus capecitabine group included thrombo-cytopenia (31% vs 3%), constipation (27% vs 11%), increased amino transferase levels (29% vs 14%), headache (28% vs 15%), epistaxis (23% vs 8%), arthralgia (19% vs 8%), pyrexia (19% vs 8%), dry mouth (17% vs 5%), and myalgia (14% vs 4%).|NA", "tmkp_ids": ["tmkp:8fdf1c841e8c1bcd215311f8d96f2953f8e11c41f38a9d3dbbc763e3f572d21c"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB05773", "original_object": "HP:0003326"}
{"subject": "UMLS:C1515454", "predicate": "biolink:subclass_of", "object": "UBERON:0000475", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C40046", "original_object": "NCIT:C32221"}
{"subject": "CAID:CA409120239", "predicate": "biolink:is_nonsense_variant_of", "object": "NCBIGene:100", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "stop_gained", "original_subject": "CAID:CA409120239", "original_object": "ENSEMBL:ENSG00000196839"}
{"subject": "CAID:CA409120239", "predicate": "biolink:is_nonsense_variant_of", "object": "NCBIGene:100", "primary_knowledge_source": "infores:robokop-snpeff", "knowledge_level": "prediction", "agent_type": "computational_model", "snpeff_effect": "stop_gained", "original_subject": "CAID:CA409120239", "original_object": "ENSEMBL:ENSG00000196839"}
{"subject": "GO:0150034", "predicate": "biolink:temporally_related_to", "object": "GO:0007275", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0150034", "original_object": "GO:0007275"}
{"subject": "MONDO:0021641", "predicate": "biolink:related_to", "object": "NCBITaxon:1980416", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0021641", "original_object": "NCBITaxon:1980416"}
{"subject": "CHEBI:82451", "predicate": "biolink:associated_with_increased_likelihood_of", "object": "MONDO:0005059", "primary_knowledge_source": "infores:cebs", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["TR:TR-128"], "anatomical_context_qualifier": "UBERON:0002193", "sex_qualifier": "male", "species_context_qualifier": "NCBITaxon:10116", "population_context_qualifier": "RGD:13506918", "original_subject": "INCHIKEY:QZWKEPYTBWZJJA-UHFFFAOYSA-N", "original_object": "DOID:1240"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0015758", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00959_MESH_D009182_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "HP:0012192"}
{"subject": "CHEBI:133354", "predicate": "biolink:has_part", "object": "CHEBI:133353", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:133354", "original_object": "CHEBI:133353"}
{"subject": "HP:0012465", "predicate": "biolink:occurs_in", "object": "MONDO:0019402", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01609_MESH_D017086_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012465", "original_object": "MESH:D017086"}
{"subject": "CL:1000147", "predicate": "biolink:develops_from", "object": "UBERON:0000948", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:1000147", "original_object": "UBERON:0000948"}
{"subject": "CHEBI:2533", "predicate": "biolink:affects", "object": "MONDO:0008315", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:27917368"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:C000188", "original_object": "MESH:D011471"}
{"subject": "MONDO:0005036", "predicate": "biolink:disease_has_basis_in", "object": "REACT:R-HSA-9710468", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DOID:3717", "original_object": "REACT:R-HSA-9710468"}
{"subject": "CHEBI:22977", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005258", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:33765546"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D002104", "original_object": "MESH:D000067877"}
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{"subject": "CHEBI:50275", "predicate": "biolink:applied_to_treat", "object": "UMLS:C0041909", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1055", "original_object": "UMLS:C0041909"}
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{"subject": "CHEBI:81881", "predicate": "biolink:related_to", "object": "CHEBI:26155", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:81881", "original_object": "CHEBI:26155"}
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{"subject": "UMLS:C0657912", "predicate": "biolink:causes", "object": "HP:0000613", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00230", "original_object": "UMLS:C0085636"}
{"subject": "CHEBI:50378", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:94501", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:115355", "original_object": "PUBCHEM.COMPOUND:5284566"}
{"subject": "CHEBI:46345", "predicate": "biolink:increases_sensitivity_to", "object": "NCBIGene:7372", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "9606", "publications": ["PMID:17854773"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005472", "original_object": "NCBIGENE:7372"}
{"subject": "CHEBI:46345", "predicate": "biolink:increases_sensitivity_to", "object": "NCBIGene:7372", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "9606", "publications": ["PMID:17854773"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005472", "original_object": "NCBIGENE:7372"}
{"subject": "CHEBI:46345", "predicate": "biolink:increases_sensitivity_to", "object": "NCBIGene:7372", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "9606", "publications": ["PMID:17854773"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005472", "original_object": "NCBIGENE:7372"}
{"subject": "CHEBI:46345", "predicate": "biolink:increases_sensitivity_to", "object": "NCBIGene:7372", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "9606", "publications": ["PMID:17854773"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005472", "original_object": "NCBIGENE:7372"}
{"subject": "UNII:76JZE5DSN6", "predicate": "biolink:contributes_to", "object": "HP:0002015", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:9088458"], "tmkp_confidence_score": 0.99887985, "sentences": "An elderly female in her late 50s with a medical history of hypertension, developed acute onset facial puffiness, dysphagia, tongue, and neck swelling, with onset 1 week after the first dose of the BBV152 vaccine.|NA", "tmkp_ids": ["tmkp:51581b2716ebb0f9c05029fcc784614830f4e5f71331743f739e9cddec54b74b"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB15847", "original_object": "HP:0002015"}
{"subject": "CHEBI:52446", "predicate": "biolink:has_part", "object": "CHEBI:52527", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:52446", "original_object": "CHEBI:52527"}
{"subject": "GO:0018104", "predicate": "biolink:contributes_to", "object": "GO:0005618", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01333_MESH_D012141_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0018104", "original_object": "GO:0005618"}
{"subject": "GO:1901696", "predicate": "biolink:has_output", "object": "CHEBI:67194", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1901696", "original_object": "CHEBI:67194"}
{"subject": "CHEBI:131804", "predicate": "biolink:related_to", "object": "CHEBI:131805", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:131804", "original_object": "CHEBI:131805"}
{"subject": "CHEMBL.COMPOUND:CHEMBL426414", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:1814", "primary_knowledge_source": "infores:pharos", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 8.1, "affinity_parameter": "pKd", "publications": ["PMID:16335915"], "original_subject": "CHEMBL.COMPOUND:CHEMBL426414", "original_object": "HGNC:3024"}
{"subject": "CHEMBL.COMPOUND:CHEMBL426414", "predicate": "biolink:directly_physically_interacts_with", "object": "NCBIGene:1814", "primary_knowledge_source": "infores:pharos", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "affinity": 8.1, "affinity_parameter": "pKd", "publications": ["PMID:16335915"], "original_subject": "CHEMBL.COMPOUND:CHEMBL426414", "original_object": "HGNC:3024"}
{"subject": "MONDO:0019145", "predicate": "biolink:has_participant", "object": "GO:0004252", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0019145", "original_object": "GO:0004252"}
{"subject": "MESH:C515928", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "HP:0012534", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:16982702"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C515928", "original_object": "MESH:D006930"}
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{"subject": "NCBIGene:7263", "predicate": "biolink:increases_sensitivity_to", "object": "MESH:C079198", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "9606", "publications": ["PMID:16734730"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:7263", "original_object": "MESH:C079198"}
{"subject": "GO:0008900", "predicate": "biolink:positively_correlated_with", "object": "GO:0001696", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00736_MESH_D004942_1", "DB00736_MESH_D010437_1", "DB00736_MESH_D015043_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008900", "original_object": "GO:0001696"}
{"subject": "MONDO:0044784", "predicate": "biolink:related_to", "object": "NCIT:C9478", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C6577", "original_object": "NCIT:C9478"}
{"subject": "GO:0008217", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0005044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06762_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008217", "original_object": "MESH:D006973"}
{"subject": "CHEBI:4514", "predicate": "biolink:subclass_of", "object": "CHEBI:32952", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:4514", "original_object": "CHEBI:32952"}
{"subject": "NCBIGene:213", "predicate": "biolink:contributes_to", "object": "MONDO:0005011", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5748756", "PMC:5748756"], "tmkp_confidence_score": 0.6563026483744889, "sentences": "In this animal model of CD, induced by peptidoglycan-polysaccharide (PG-PS) or human serum albumin (HSA), they observed that resveratrol decreased inflammation and fibrosis in the intestinal wall of rats.|NA|In this animal model of CD, induced by peptidoglycan-polysaccharide (PG-PS) or human serum albumin (HSA), they observed that resveratrol decreased inflammation and fibrosis in the intestinal wall of rats.|NA", "tmkp_ids": ["tmkp:aaa23f11c13a7e70aac090a3628d301133c3f555e1a83a535cc8dc8ab5369eb4", "tmkp:4393fd6a2d7f463e341e591f8b07f88673646081dd594a8088155f9ea99be3e5"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "DRUGBANK:DB00062", "original_object": "MONDO:0005011"}
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{"subject": "MESH:D062065", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005093", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:18005315"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D062065", "original_object": "MESH:D012871"}
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{"subject": "GO:0019627", "predicate": "biolink:has_participant", "object": "CHEBI:16199", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019627", "original_object": "CHEBI:16199"}
{"subject": "CL:0003012", "predicate": "biolink:overlaps", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0003012", "original_object": "NCBITaxon:6072"}
{"subject": "CHEBI:17234", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005148", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00284_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17234", "original_object": "MESH:D003924"}
{"subject": "MONDO:0005224", "predicate": "biolink:affects", "object": "UMLS:C1514037", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C3249", "original_object": "NCIT:C37179"}
{"object": "MONDO:0019087", "predicate": "biolink:causes", "subject": "UBERON:0002394", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0019087", "original_subject": "UBERON:0002394"}
{"subject": "UBERON:0001460", "predicate": "biolink:coexists_with", "object": "UBERON:0001467", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001460", "original_object": "UBERON:0001467"}
{"subject": "NCBIGene:1536", "predicate": "biolink:increases_sensitivity_to", "object": "MESH:D052638", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "10090", "publications": ["PMID:15319363"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:1536", "original_object": "MESH:D052638"}
{"subject": "NCBIGene:1536", "predicate": "biolink:increases_sensitivity_to", "object": "MESH:D052638", "primary_knowledge_source": "infores:ctd", "description": "increases response to", "taxon": "10090", "publications": ["PMID:15319363"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:1536", "original_object": "MESH:D052638"}
{"subject": "HP:0012844", "predicate": "biolink:has_phenotype", "object": "MONDO:0007758", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C4113", "original_object": "NCIT:C35541"}
{"subject": "UBERON:0005051", "predicate": "biolink:overlaps", "object": "GO:0071944", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0005051", "original_object": "GO:0071944"}
{"subject": "GO:0060638", "predicate": "biolink:occurs_in", "object": "CL:0008019", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060638", "original_object": "CL:0008019"}
{"subject": "GO:0140619", "predicate": "biolink:regulates", "object": "GO:0000150", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0140619", "original_object": "GO:0000150", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "MESH:D001335", "predicate": "biolink:affects", "object": "NCBIGene:3586", "primary_knowledge_source": "infores:ctd", "description": "increases expression of", "taxon": "10090", "publications": ["PMID:28669936", "PMID:14594659", "PMID:18406506", "PMID:8765825", "PMID:12217215", "PMID:17620185", "PMID:19074765"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D001335", "original_object": "NCBIGENE:3586", "object_aspect_qualifier": "expression", "object_direction_qualifier": "increased", "qualified_predicate": "biolink:causes"}
{"subject": "MESH:D001335", "predicate": "biolink:affects", "object": "NCBIGene:3586", "primary_knowledge_source": "infores:ctd", "description": "increases expression of", "taxon": "10090", "publications": ["PMID:28669936", "PMID:14594659", "PMID:18406506", "PMID:8765825", "PMID:12217215", "PMID:17620185", "PMID:19074765"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D001335", "original_object": "NCBIGENE:3586", "object_aspect_qualifier": "expression", "object_direction_qualifier": "increased", "qualified_predicate": "biolink:causes"}
{"subject": "GO:0048731", "predicate": "biolink:has_output", "object": "UBERON:0000467", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0048731", "original_object": "UBERON:0000467"}
{"subject": "CHEBI:63556", "predicate": "biolink:has_part", "object": "CHEBI:53621", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:63556", "original_object": "CHEBI:53621"}
{"subject": "CHEBI:89510", "predicate": "biolink:correlated_with", "object": "NCBIGene:2688", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:8729530", "PMID:9640412", "PMID:16384844"], "original_subject": "HMDB:HMDB0000569", "original_object": "OMIM:139250"}
{"subject": "CHEBI:89510", "predicate": "biolink:correlated_with", "object": "NCBIGene:2688", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:8729530", "PMID:9640412", "PMID:16384844"], "original_subject": "HMDB:HMDB0000569", "original_object": "OMIM:139250"}
{"subject": "GO:0060956", "predicate": "biolink:causes", "object": "CL:0002350", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060956", "original_object": "CL:0002350"}
{"subject": "CHEBI:17015", "predicate": "biolink:similar_to", "object": "CHEBI:16238", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00140", "original_object": "DRUGBANK:DB03147"}
{"subject": "CHEBI:17015", "predicate": "biolink:similar_to", "object": "CHEBI:16238", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00140", "original_object": "DRUGBANK:DB03147"}
{"subject": "GO:0036398", "predicate": "biolink:overlaps", "object": "GO:0005886", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0036398", "original_object": "GO:0005886"}
{"object": "UBERON:0034993", "predicate": "biolink:has_part", "subject": "UBERON:0001925", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0034993", "original_subject": "UBERON:0001925"}
{"subject": "UBERON:6001649", "predicate": "biolink:contributes_to", "object": "UBERON:0003142", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "FBbt:00001649", "original_object": "UBERON:0003142"}
{"subject": "NCBIGene:6863", "predicate": "biolink:negatively_correlated_with", "object": "GO:0098818", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00454_MESH_D010146_1", "DB00454_MESH_D048949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P20366", "original_object": "GO:0098818"}
{"subject": "NCBIGene:6863", "predicate": "biolink:negatively_correlated_with", "object": "GO:0098818", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00454_MESH_D010146_1", "DB00454_MESH_D048949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P20366", "original_object": "GO:0098818"}
{"subject": "GO:0006270", "predicate": "biolink:precedes", "object": "REACT:R-PFA-68962", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006270", "original_object": "REACT:R-PFA-68962"}
{"subject": "UBERON:0011695", "predicate": "biolink:develops_from", "object": "CL:0000365", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0011695", "original_object": "CL:0000365"}
{"subject": "CHEBI:17688", "predicate": "biolink:affects", "object": "MONDO:0005002", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:30576219"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D009538", "original_object": "MESH:D029424"}
{"subject": "CHEBI:36080", "predicate": "biolink:subclass_of", "object": "PR:000000001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:36080", "original_object": "PR:000000001"}
{"subject": "NCBIGene:6910", "predicate": "biolink:acts_upstream_of", "object": "GO:1901846", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:15289437"], "original_subject": "UniProtKB:Q99593", "original_object": "GO:1901846"}
{"subject": "NCBIGene:6910", "predicate": "biolink:acts_upstream_of", "object": "GO:1901846", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:15289437"], "original_subject": "UniProtKB:Q99593", "original_object": "GO:1901846"}
{"subject": "MONDO:0001501", "predicate": "biolink:affects", "object": "UBERON:0003693", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C4832", "original_object": "NCIT:C12298"}
{"subject": "GO:0120111", "predicate": "biolink:related_to", "object": "GO:0019226", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0120111", "original_object": "GO:0019226"}
{"subject": "NCBIGene:401024", "predicate": "biolink:acts_upstream_of_or_within_positive_effect", "object": "GO:0007288", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:30745215", "PMID:30137358"], "original_subject": "UniProtKB:Q5CZC0", "original_object": "GO:0007288"}
{"subject": "NCBIGene:401024", "predicate": "biolink:acts_upstream_of_or_within_positive_effect", "object": "GO:0007288", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:30745215", "PMID:30137358"], "original_subject": "UniProtKB:Q5CZC0", "original_object": "GO:0007288"}
{"subject": "NCBIGene:6573", "predicate": "biolink:affects_sensitivity_to", "object": "CHEBI:35842", "primary_knowledge_source": "infores:ctd", "description": "affects response to", "taxon": "9606", "publications": ["PMID:18322994"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:6573", "original_object": "MESH:D018501"}
{"subject": "NCBIGene:6573", "predicate": "biolink:affects_sensitivity_to", "object": "CHEBI:35842", "primary_knowledge_source": "infores:ctd", "description": "affects response to", "taxon": "9606", "publications": ["PMID:18322994"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:6573", "original_object": "MESH:D018501"}
{"subject": "MONDO:0001898", "predicate": "biolink:affects", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000610", "original_object": "NCBITaxon:6072"}
{"subject": "GO:1990257", "predicate": "biolink:develops_from", "object": "UBERON:0016880", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990257", "original_object": "UBERON:0016880"}
{"subject": "GO:0022016", "predicate": "biolink:occurs_in", "object": "UBERON:0000955", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0022016", "original_object": "UBERON:0000955"}
{"subject": "GO:0071897", "predicate": "biolink:correlated_with", "object": "GO:0008283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00791_MESH_D008228_1", "DB00791_MESH_D015451_1", "DB00791_MESH_D015464_1", "DB00791_MESH_D011087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071897", "original_object": "GO:0008283"}
{"subject": "GO:0034188", "predicate": "biolink:precedes", "object": "GO:0009987", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0034188", "original_object": "GO:0009987"}
{"subject": "CL:0000091", "predicate": "biolink:located_in", "object": "UBERON:0000949", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000091", "original_object": "UBERON:0000949"}
{"object": "GO:0033360", "predicate": "biolink:has_participant", "subject": "CHEBI:58117", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0033360", "original_subject": "CHEBI:58117"}
{"object": "CHEBI:17627", "predicate": "biolink:has_participant", "subject": "SMPDB:SMP0000220", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HMDB:HMDB0003178", "original_subject": "SMPDB:SMP0000220"}
{"subject": "CHEBI:76358", "predicate": "biolink:has_part", "object": "CHEBI:76358", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:76359", "original_object": "CHEBI:76358"}
{"subject": "GO:0015720", "predicate": "biolink:has_input", "object": "CHEBI:15676", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015720", "original_object": "CHEBI:15676"}
{"object": "GO:0030876", "predicate": "biolink:has_participant", "subject": "GO:0071345", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0030876", "original_subject": "GO:0071345"}
{"subject": "NCBIGene:254531", "predicate": "biolink:regulates", "object": "CHEBI:15346", "primary_knowledge_source": "infores:metabolomics_workbench", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "HGNC:30059", "original_object": "PUBCHEM.COMPOUND:87642"}
{"subject": "NCBIGene:254531", "predicate": "biolink:regulates", "object": "CHEBI:15346", "primary_knowledge_source": "infores:metabolomics_workbench", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "HGNC:30059", "original_object": "PUBCHEM.COMPOUND:87642"}
{"subject": "GO:0070434", "predicate": "biolink:regulates", "object": "GO:0070431", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0070434", "original_object": "GO:0070431", "object_aspect_qualifier": "activity_or_abundance", "object_direction_qualifier": "upregulated", "qualified_predicate": "biolink:causes"}
{"subject": "CHEBI:16526", "predicate": "biolink:correlated_with", "object": "HP:0001950", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00819_MESH_D000532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002245", "original_object": "HP:0001950"}
{"subject": "CHEBI:16526", "predicate": "biolink:correlated_with", "object": "HP:0001950", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00819_MESH_D000532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002245", "original_object": "HP:0001950"}
{"subject": "MESH:D022882", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0005059", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:16319293"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D022882", "original_object": "MESH:D007938"}
{"subject": "CHEBI:33744", "predicate": "biolink:has_part", "object": "CHEBI:33356", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:33744", "original_object": "CHEBI:33356"}
{"subject": "CHEBI:33853", "predicate": "biolink:positively_correlated_with", "object": "EFO:0004344", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:18709157", "PMID:21900077", "PMID:25061923"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010636", "original_object": "MESH:D001724"}
{"subject": "CL:0000921", "predicate": "biolink:related_to", "object": "CHEBI:24402", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000921", "original_object": "CHEBI:24402"}
{"subject": "NCBIGene:6580", "predicate": "biolink:located_in", "object": "UBERON:0008404", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:O15245", "original_object": "UBERON:0008404"}
{"subject": "NCBIGene:6580", "predicate": "biolink:located_in", "object": "UBERON:0008404", "primary_knowledge_source": "infores:reactome", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:O15245", "original_object": "UBERON:0008404"}
{"subject": "CHEBI:59057", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:42567", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:6634", "original_object": "PUBCHEM.COMPOUND:5281614"}
{"subject": "CL:0000771", "predicate": "biolink:related_to", "object": "GO:0004930", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000771", "original_object": "GO:0004930"}
{"subject": "NCBIGene:5743", "predicate": "biolink:target_for", "object": "HP:0002315", "drugmechdb_path_id": ["DB09213_MESH_D006261_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "primary_knowledge_source": "infores:drugmechdb", "original_subject": "UniProtKB:P35354", "original_object": "MESH:D006261"}
{"subject": "NCBIGene:5743", "predicate": "biolink:target_for", "object": "HP:0002315", "drugmechdb_path_id": ["DB09213_MESH_D006261_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "primary_knowledge_source": "infores:drugmechdb", "original_subject": "UniProtKB:P35354", "original_object": "MESH:D006261"}
{"subject": "CHEBI:132833", "predicate": "biolink:subclass_of", "object": "CHEBI:60911", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:132833", "original_object": "CHEBI:60911"}
{"subject": "MONDO:0019189", "predicate": "biolink:disrupts", "object": "GO:0006082", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0019189", "original_object": "GO:0006082"}
{"subject": "CHEBI:75736", "predicate": "biolink:subclass_of", "object": "CHEBI:60004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:75736", "original_object": "CHEBI:60004"}
{"subject": "CHEBI:7494", "predicate": "biolink:causes", "object": "UMLS:C1142135", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01149", "original_object": "UMLS:C1142135"}
{"subject": "CHEBI:7494", "predicate": "biolink:causes", "object": "UMLS:C1142135", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB01149", "original_object": "UMLS:C1142135"}
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{"subject": "GO:0071036", "predicate": "biolink:overlaps", "object": "GO:0010467", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071036", "original_object": "GO:0010467"}
{"subject": "CHEBI:31644", "predicate": "biolink:causes", "object": "UMLS:C0277925", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00538", "original_object": "UMLS:C0277925"}
{"subject": "GO:0086016", "predicate": "biolink:occurs_in", "object": "UBERON:0002085", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0086016", "original_object": "UBERON:0002085"}
{"subject": "NCBIGene:31444", "predicate": "biolink:decreases_sensitivity_to", "object": "CHEBI:28786", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "7227", "publications": ["PMID:15530657"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:31444", "original_object": "MESH:D010269"}
{"subject": "NCBIGene:31444", "predicate": "biolink:decreases_sensitivity_to", "object": "CHEBI:28786", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "7227", "publications": ["PMID:15530657"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:31444", "original_object": "MESH:D010269"}
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{"subject": "NCBIGene:150", "predicate": "biolink:correlated_with", "object": "MONDO:0002009", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06148_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08913", "original_object": "MESH:D003865"}
{"subject": "NCBIGene:150", "predicate": "biolink:correlated_with", "object": "MONDO:0002009", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06148_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08913", "original_object": "MESH:D003865"}
{"subject": "UNII:DJX4AL4ENX", "predicate": "biolink:positively_correlated_with", "object": "GO:0035861", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01262_MESH_D015470_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PUBCHEM.COMPOUND:126357", "original_object": "GO:0035861"}
{"subject": "HP:0002938", "predicate": "biolink:has_part", "object": "MONDO:0003280", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002938", "original_object": "HP:0003307"}
{"subject": "GO:0014055", "predicate": "biolink:regulates", "object": "UBERON:0007652", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01233_MESH_D005764_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0014055", "original_object": "UBERON:0007652"}
{"subject": "GO:0036098", "predicate": "biolink:affects", "object": "CL:0000016", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0036098", "original_object": "CL:0000016"}
{"subject": "UMLS:C0065374", "predicate": "biolink:treats", "object": "MONDO:0005100", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00722", "original_object": "DOID:418"}
{"subject": "GO:0006874", "predicate": "biolink:positively_correlated_with", "object": "GO:0001503", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00481_MESH_D015663_1", "DB06401_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006874", "original_object": "GO:0001503"}
{"subject": "PR:000036841", "predicate": "biolink:has_part", "object": "PR:000036831", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:000036841", "original_object": "PR:000036831"}
{"subject": "UBERON:0008877", "predicate": "biolink:subclass_of", "object": "GO:0005604", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0008877", "original_object": "UBERON:0005769"}
{"object": "NCBIGene:4986", "predicate": "biolink:has_participant", "subject": "GO:0038003", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01183_MESH_D009293_1", "DB01183_MESH_D010146_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P41145", "original_subject": "GO:0038003"}
{"object": "NCBIGene:4986", "predicate": "biolink:has_participant", "subject": "GO:0038003", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01183_MESH_D009293_1", "DB01183_MESH_D010146_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P41145", "original_subject": "GO:0038003"}
{"subject": "CHEBI:4055", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:16551", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:10235", "original_object": "PUBCHEM.COMPOUND:7427"}
{"subject": "CHEBI:38007", "predicate": "biolink:subclass_of", "object": "CHEBI:16382", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:38007", "original_object": "CHEBI:24858"}
{"subject": "MONDO:0005311", "predicate": "biolink:contributes_to", "object": "HP:0001681", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09069_MESH_D000787_1", "DB01076_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002621", "original_object": "MESH:D000787"}
{"subject": "CHEBI:3160", "predicate": "biolink:has_adverse_event", "object": "HP:0001945", "primary_knowledge_source": "infores:faers", "aggregator_knowledge_source": ["infores:drugcentral"], "FAERS_llr": 200.792, "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5368", "original_object": "MEDDRA:10037660"}
{"subject": "GO:0031569", "predicate": "biolink:related_to", "object": "GO:0051319", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0031569", "original_object": "GO:0051319"}
{"subject": "UMLS:C0010592", "predicate": "biolink:causes", "object": "UMLS:C0240035", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00091", "original_object": "UMLS:C0240035"}
{"subject": "GO:0045480", "predicate": "biolink:has_participant", "object": "CHEBI:28260", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0045480", "original_object": "CHEBI:4139"}
{"subject": "GO:1904176", "predicate": "biolink:capable_of", "object": "GO:0018835", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1904176", "original_object": "GO:0018835"}
{"subject": "HP:0005229", "predicate": "biolink:affects", "object": "UBERON:0001062", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0005229", "original_object": "UBERON:0001062"}
{"subject": "GO:0080145", "predicate": "biolink:related_to", "object": "CHEBI:15356", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0080145", "original_object": "CHEBI:35237"}
{"subject": "PR:000044456", "predicate": "biolink:derives_from", "object": "PR:000044455", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:000044456", "original_object": "PR:000044455"}
{"object": "UBERON:0006913", "predicate": "biolink:has_part", "subject": "UBERON:0001833", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0006913", "original_subject": "UBERON:0001833"}
{"subject": "HP:0012514", "predicate": "biolink:correlated_with", "object": "MONDO:0005391", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08872_MESH_D012148_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012514", "original_object": "MESH:D012148"}
{"subject": "CHEBI:83611", "predicate": "biolink:related_to", "object": "CHEBI:83604", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:83611", "original_object": "CHEBI:83604"}
{"subject": "CHEBI:6078", "predicate": "biolink:has_part", "object": "CHEBI:63943", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:6078", "original_object": "CHEBI:63943"}
{"subject": "GO:0006281", "predicate": "biolink:occurs_in", "object": "MONDO:0005060", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05109_MESH_D008080_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006281", "original_object": "MESH:D008080"}
{"subject": "HP:0000308", "predicate": "biolink:has_part", "object": "HP:0000347", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000308", "original_object": "HP:0000347"}
{"subject": "UBERON:0002522", "predicate": "biolink:related_to", "object": "CL:0000034", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002522", "original_object": "CL:0000034"}
{"subject": "CL:0000454", "predicate": "biolink:capable_of", "object": "GO:0048242", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000454", "original_object": "GO:0048242"}
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{"subject": "CHEBI:35028", "predicate": "biolink:associated_with_likelihood_of", "object": "MONDO:0002616", "primary_knowledge_source": "infores:cebs", "knowledge_level": "observation", "agent_type": "manual_agent", "publications": ["TR:TR-576"], "anatomical_context_qualifier": "UBERON:0000995", "sex_qualifier": "female", "species_context_qualifier": "NCBITaxon:10090", "original_subject": "INCHIKEY:DAKWPKUUDNSNPN-UHFFFAOYSA-N", "original_object": "MONDO:0002616"}
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{"subject": "CHEBI:132236", "predicate": "biolink:subclass_of", "object": "CHEBI:32952", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:132236", "original_object": "CHEBI:32952"}
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{"subject": "CHEBI:231691", "predicate": "biolink:has_part", "object": "CHEBI:62944", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:231691", "original_object": "CHEBI:62944"}
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{"subject": "CHEBI:4814", "predicate": "biolink:chemically_similar_to", "object": "PUBCHEM.COMPOUND:6610281", "primary_knowledge_source": "infores:lincs", "knowledge_level": "knowledge_assertion", "agent_type": "data_analysis_pipeline", "original_subject": "PUBCHEM.COMPOUND:5281037", "original_object": "PUBCHEM.COMPOUND:6610281"}
{"subject": "CHEBI:64019", "predicate": "biolink:decreases_sensitivity_to", "object": "NCBIGene:1906", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "9986", "publications": ["PMID:18435936"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000068577", "original_object": "NCBIGENE:1906"}
{"subject": "CHEBI:64019", "predicate": "biolink:decreases_sensitivity_to", "object": "NCBIGene:1906", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "9986", "publications": ["PMID:18435936"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000068577", "original_object": "NCBIGENE:1906"}
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{"subject": "CHEBI:28694", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0005258", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:33765546"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D003300", "original_object": "MESH:D000067877"}
{"subject": "CHEBI:16857", "predicate": "biolink:correlated_with", "object": "NCBIGene:5310", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:18215696", "PMID:21389975"], "original_subject": "HMDB:HMDB0000167", "original_object": "OMIM:601313"}
{"subject": "CHEBI:16857", "predicate": "biolink:correlated_with", "object": "NCBIGene:5310", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:18215696", "PMID:21389975"], "original_subject": "HMDB:HMDB0000167", "original_object": "OMIM:601313"}
{"subject": "NCBIGene:345", "predicate": "biolink:positively_correlated_with", "object": "MESH:D015243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04145_MESH_D006949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P02656", "original_object": "MESH:D015243"}
{"subject": "NCBIGene:345", "predicate": "biolink:positively_correlated_with", "object": "MESH:D015243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04145_MESH_D006949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P02656", "original_object": "MESH:D015243"}
{"subject": "GO:0001508", "predicate": "biolink:regulates", "object": "CL:0000197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00527_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0001508", "original_object": "CL:0000197"}
{"subject": "UNII:I0BGE6P6I6", "predicate": "biolink:treats", "object": "MONDO:0100096", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5501", "original_object": "UMLS:C5203670"}
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{"subject": "GO:0062156", "predicate": "biolink:related_to", "object": "GO:0005743", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0062156", "original_object": "GO:0005743"}
{"subject": "GO:0086041", "predicate": "biolink:occurs_in", "object": "UBERON:0001009", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0086041", "original_object": "UBERON:0001009"}
{"subject": "CHEBI:18022", "predicate": "biolink:subclass_of", "object": "HP:0000118", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:30951", "original_object": "HP:0000118"}
{"subject": "CL:4023116", "predicate": "biolink:related_to", "object": "UBERON:0002227", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:4023116", "original_object": "UBERON:0002227"}
{"subject": "CHEBI:50749", "predicate": "biolink:has_part", "object": "CHEBI:50749", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:90861", "original_object": "CHEBI:50749"}
{"subject": "MONDO:0002267", "predicate": "biolink:positively_correlated_with", "object": "HP:0012735", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11359_MESH_D003139_1", "DB11359_MESH_D012220_1", "DB11359_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0006536", "original_object": "HP:0012735"}
{"subject": "CHEBI:18243", "predicate": "biolink:located_in", "object": "UBERON:0001910", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00850_MESH_D012559_1", "DB01224_MESH_D012559_1", "DB08922_MESH_D012559_1", "DB04842_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:18243", "original_object": "UBERON:0001910"}
{"subject": "CHEBI:18243", "predicate": "biolink:located_in", "object": "UBERON:0001910", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00850_MESH_D012559_1", "DB01224_MESH_D012559_1", "DB08922_MESH_D012559_1", "DB04842_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:18243", "original_object": "UBERON:0001910"}
{"subject": "CHEBI:3752", "predicate": "biolink:affects", "object": "CHEBI:81569", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00882_MESH_D007247_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D002996", "original_object": "MESH:D005640"}
{"subject": "CHEBI:3752", "predicate": "biolink:affects", "object": "CHEBI:81569", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00882_MESH_D007247_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D002996", "original_object": "MESH:D005640"}
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{"subject": "CHEBI:25029", "predicate": "biolink:positively_correlated_with", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D009450_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D003876_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D003877_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:25029", "original_object": "GO:0006954"}
{"subject": "NCBIGene:11180", "predicate": "biolink:acts_upstream_of_negative_effect", "object": "GO:0070314", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:17216128"], "original_subject": "UniProtKB:Q9NNW5", "original_object": "GO:0070314"}
{"subject": "NCBIGene:11180", "predicate": "biolink:acts_upstream_of_negative_effect", "object": "GO:0070314", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:17216128"], "original_subject": "UniProtKB:Q9NNW5", "original_object": "GO:0070314"}
{"subject": "HP:0012531", "predicate": "biolink:manifestation_of", "object": "HP:0003418", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01744_MESH_D001416_1", "DB06774_MESH_D001416_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0012531", "original_object": "MESH:D001416"}
{"subject": "UBERON:0001645", "predicate": "biolink:contributes_to", "object": "HP:0025095", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08799_MESH_D012912_1", "DB00434_MESH_D012912_2", "DB00637_MESH_D012912_1", "DB01114_MESH_D012912_1", "DB06691_MESH_D012912_1", "DB09488_MESH_D012912_1", "DB00719_MESH_D012912_1", "DB00950_MESH_D012912_1", "DB00434_MESH_D012912_1", "DB01176_MESH_D012912_1", "DB00341_MESH_D012912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001645", "original_object": "MESH:D012912"}
{"subject": "CHEBI:28648", "predicate": "biolink:located_in", "object": "CL:0001063", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09077_MESH_D009447_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:28648", "original_object": "CL:0001063"}
{"subject": "CHEBI:32016", "predicate": "biolink:contraindicated_in", "object": "CHEBI:5138", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4224", "original_object": "UMLS:C0085228"}
{"subject": "CHEBI:32016", "predicate": "biolink:contraindicated_in", "object": "CHEBI:5138", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4224", "original_object": "UMLS:C0085228"}
{"subject": "CHEBI:32016", "predicate": "biolink:contraindicated_in", "object": "CHEBI:5138", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4224", "original_object": "UMLS:C0085228"}
{"subject": "CHEBI:32016", "predicate": "biolink:contraindicated_in", "object": "CHEBI:5138", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4224", "original_object": "UMLS:C0085228"}
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{"subject": "CHEBI:132146", "predicate": "biolink:subclass_of", "object": "PR:000000001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:132146", "original_object": "PR:000000001"}
{"subject": "MONDO:0037748", "predicate": "biolink:affects", "object": "CHEBI:50404", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0010980", "original_object": "CHEBI:50404"}
{"subject": "CHEBI:61599", "predicate": "biolink:related_to", "object": "CHEBI:139252", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:61599", "original_object": "CHEBI:139252"}
{"subject": "UBERON:0000479", "predicate": "biolink:has_part", "object": "GO:0031012", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000479", "original_object": "GO:0031012"}
{"subject": "UBERON:8600026", "predicate": "biolink:composed_primarily_of", "object": "UBERON:0007106", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:8600026", "original_object": "UBERON:0007106"}
{"subject": "CHEBI:15430", "predicate": "biolink:correlated_with", "object": "MONDO:0008319", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:13765301"], "original_subject": "HMDB:HMDB0000241", "original_object": "OMIM:177000"}
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{"subject": "GO:0098686", "predicate": "biolink:related_to", "object": "CL:0000034", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098686", "original_object": "CL:0000034"}
{"subject": "UNII:5BSH2G9BH8", "predicate": "biolink:chemically_similar_to", "object": "NCBIGene:6439", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04897_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C502722", "original_object": "UniProtKB:P07988"}
{"subject": "UNII:5BSH2G9BH8", "predicate": "biolink:chemically_similar_to", "object": "NCBIGene:6439", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04897_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C502722", "original_object": "UniProtKB:P07988"}
{"object": "NCBIGene:2488", "predicate": "biolink:gene_product_of", "subject": "CHEBI:81569", "primary_knowledge_source": "infores:gtopdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HGNC:3964", "original_subject": "GTOPDB:1157"}
{"object": "NCBIGene:2488", "predicate": "biolink:gene_product_of", "subject": "CHEBI:81569", "primary_knowledge_source": "infores:gtopdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "HGNC:3964", "original_subject": "GTOPDB:1157"}
{"subject": "GO:0036480", "predicate": "biolink:occurs_in", "object": "UBERON:0001016", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0036480", "original_object": "UBERON:0001016"}
{"subject": "CHEBI:30956", "predicate": "biolink:affects", "object": "EFO:0004344", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:22225821"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D014238", "original_object": "MESH:D001724"}
{"subject": "CHEBI:30956", "predicate": "biolink:affects", "object": "EFO:0004344", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:22225821"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D014238", "original_object": "MESH:D001724"}
{"subject": "MONDO:0006496", "predicate": "biolink:occurs_in", "object": "NCBITaxon:6181", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01058_MESH_D012552_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0003470", "original_object": "NCBITaxon:6181"}
{"subject": "REACT:R-HSA-2162123", "predicate": "biolink:affects", "object": "CHEBI:15627", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00806_MESH_D016491_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "REACT:R-HSA-2162123", "original_object": "MESH:D013928"}
{"subject": "UniProtKB:Q05486", "predicate": "biolink:capable_of", "object": "GO:0003964", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01265_MESH_D019694_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q05486", "original_object": "GO:0003964"}
{"subject": "UMLS:C0009315", "predicate": "biolink:disrupts", "object": "GO:0061701", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01111_MESH_D004927_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C004691", "original_object": "GO:0061701"}
{"subject": "GO:0000333", "predicate": "biolink:related_to", "object": "CHEBI:16991", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000333", "original_object": "CHEBI:16991"}
{"subject": "CHEBI:17154", "predicate": "biolink:affects", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D009536", "original_object": "UBERON:0001866"}
{"subject": "CHEBI:17154", "predicate": "biolink:affects", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02701_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D009536", "original_object": "UBERON:0001866"}
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{"subject": "CHEBI:16977", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0022650", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4255", "original_object": "UMLS:C0022650"}
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{"subject": "CHEBI:3655", "predicate": "biolink:regulates", "object": "GO:0016917", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00356_MESH_D009128_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D002753", "original_object": "GO:0016917"}
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{"subject": "MONDO:0010052", "predicate": "biolink:has_participant", "object": "NCBIGene:50511", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0010052", "original_object": "HGNC:18130"}
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{"subject": "GO:0001880", "predicate": "biolink:has_input", "object": "UBERON:0003890", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0001880", "original_object": "UBERON:0003890"}
{"subject": "GO:0099154", "predicate": "biolink:capable_of", "object": "GO:0008150", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0099154", "original_object": "GO:0008150"}
{"subject": "NCBIGene:10019", "predicate": "biolink:acts_upstream_of_or_within_negative_effect", "object": "GO:0038163", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:27430239", "PMID:20404132"], "original_subject": "UniProtKB:Q9UQQ2", "original_object": "GO:0038163"}
{"subject": "NCBIGene:10019", "predicate": "biolink:acts_upstream_of_or_within_negative_effect", "object": "GO:0038163", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:27430239", "PMID:20404132"], "original_subject": "UniProtKB:Q9UQQ2", "original_object": "GO:0038163"}
{"object": "GO:0035554", "predicate": "biolink:has_part", "subject": "GO:0035385", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0035554", "original_subject": "GO:0035385"}
{"object": "GO:0007269", "predicate": "biolink:has_participant", "subject": "HP:0012514", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08872_MESH_D012148_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0007269", "original_subject": "HP:0012514"}
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{"subject": "GO:0038060", "predicate": "biolink:contributes_to", "object": "GO:0042311", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08931_MESH_D000081029_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0038060", "original_object": "GO:0042311"}
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{"subject": "CHEBI:78539", "predicate": "biolink:has_metabolite", "object": "UMLS:C0085065", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13166_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C044958", "original_object": "MESH:C065520"}
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{"subject": "CHEBI:45906", "predicate": "biolink:regulates", "object": "REACT:R-HSA-70171", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04786_MESH_D014353_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D013498", "original_object": "REACT:R-HSA-70171"}
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{"subject": "CHEBI:16865", "predicate": "biolink:regulates", "object": "MONDO:0018097", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01080_MESH_D013036_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D005680", "original_object": "MESH:D013036"}
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{"subject": "GO:0050454", "predicate": "biolink:has_participant", "object": "CHEBI:133980", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0050454", "original_object": "CHEBI:133980"}
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{"subject": "MESH:C084588", "predicate": "biolink:affects", "object": "HGNC.FAMILY:180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00940_MESH_D013276_1", "DB00940_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:C084588", "original_object": "HGNC.FAMILY:180"}
{"subject": "UNII:7XL5ISS668", "predicate": "biolink:coexists_with", "object": "UNII:V7I58RC5EJ", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08870_MESH_D006689_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C547738", "original_object": "MESH:C495575"}
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{"subject": "UBERON:0004684", "predicate": "biolink:related_to", "object": "CHEBI:350546", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004684", "original_object": "CHEBI:350546"}
{"subject": "HP:0005968", "predicate": "biolink:positively_correlated_with", "object": "HP:0031217", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06401_MESH_D019584_1", "DB01395_MESH_D019584_1", "DB00286_MESH_D019584_1", "DB04575_MESH_D019584_1", "DB06710_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0005968", "original_object": "MESH:D019584"}
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{"subject": "GO:0018393", "predicate": "biolink:occurs_in", "object": "NCBIGene:4137", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08842_MESH_D000544_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0018393", "original_object": "UniProtKB:P10636"}
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{"subject": "CHEBI:26865", "predicate": "biolink:has_part", "object": "CHEBI:33353", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:26865", "original_object": "CHEBI:33353"}
{"subject": "UBERON:0014635", "predicate": "biolink:overlaps", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0014635", "original_object": "NCBITaxon:6072"}
{"subject": "NCBIGene:5153", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:176719", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01244_MESH_D000787_8"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q01064", "original_object": "MESH:D002147"}
{"subject": "NCBIGene:5153", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:176719", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01244_MESH_D000787_8"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q01064", "original_object": "MESH:D002147"}
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{"subject": "GO:0022028", "predicate": "biolink:related_to", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0022028", "original_object": "NCBITaxon:6072"}
{"subject": "MESH:C099150", "predicate": "biolink:regulates", "object": "GO:0007049", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05109_MESH_D008080_1", "DB05109_MESH_D010051_1", "DB05109_MESH_D007890_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C099150", "original_object": "GO:0007049"}
{"subject": "CHEBI:61452", "predicate": "biolink:related_to", "object": "CHEBI:131701", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:61452", "original_object": "CHEBI:131701"}
{"object": "UBERON:0004360", "predicate": "biolink:has_part", "subject": "MONDO:0004779", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "NCIT:C33732", "original_subject": "NCIT:C12328"}
{"subject": "CHEBI:135443", "predicate": "biolink:treats", "object": "MONDO:0004247", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2226", "original_object": "UMLS:C0030920"}
{"subject": "CHEBI:17987", "predicate": "biolink:affects", "object": "NCBITaxon:52283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06770_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D019905", "original_object": "NCBITaxon:52283"}
{"subject": "CHEBI:17987", "predicate": "biolink:affects", "object": "NCBITaxon:52283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06770_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D019905", "original_object": "NCBITaxon:52283"}
{"subject": "UBERON:0007475", "predicate": "biolink:composed_primarily_of", "object": "GO:0031012", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0007475", "original_object": "GO:0031012"}
{"subject": "CHEBI:28502", "predicate": "biolink:ameliorates_condition", "object": "MONDO:0005100", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["PharmacotherapyDB"], "original_subject": "DRUGBANK:DB00797", "original_object": "DOID:418"}
{"subject": "GO:0070091", "predicate": "biolink:affects", "object": "MESH:D001786", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01132_MESH_D003924_1", "DB06655_MESH_D003924_1", "DB11992_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0070091", "original_object": "MESH:D001786"}
{"subject": "CHEBI:15552", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:5739", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01240_MESH_D003139_1", "DB01240_MESH_D006976_1", "DB01240_MESH_D012220_1", "DB01240_MESH_D065631_1", "DB01240_MESH_D000081029_1", "DB01240_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011464", "original_object": "UniProtKB:P43119"}
{"subject": "CHEBI:15552", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:5739", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01240_MESH_D003139_1", "DB01240_MESH_D006976_1", "DB01240_MESH_D012220_1", "DB01240_MESH_D065631_1", "DB01240_MESH_D000081029_1", "DB01240_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011464", "original_object": "UniProtKB:P43119"}
{"subject": "CHEBI:15552", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:5739", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01240_MESH_D003139_1", "DB01240_MESH_D006976_1", "DB01240_MESH_D012220_1", "DB01240_MESH_D065631_1", "DB01240_MESH_D000081029_1", "DB01240_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011464", "original_object": "UniProtKB:P43119"}
{"subject": "CHEBI:15552", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:5739", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01240_MESH_D003139_1", "DB01240_MESH_D006976_1", "DB01240_MESH_D012220_1", "DB01240_MESH_D065631_1", "DB01240_MESH_D000081029_1", "DB01240_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011464", "original_object": "UniProtKB:P43119"}
{"object": "CL:0002453", "predicate": "biolink:has_part", "subject": "CL:0000125", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0002453", "original_subject": "CL:0000125"}
{"subject": "MESH:C078049", "predicate": "biolink:regulates", "object": "GO:0009340", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01044_MESH_D018410_1", "DB01044_MESH_D003234_1", "DB01044_MESH_D061387_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:C078049", "original_object": "GO:0009340"}
{"subject": "GO:0060612", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D005230", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060612", "original_object": "MESH:D005230"}
{"subject": "CL:0000092", "predicate": "biolink:positively_correlated_with", "object": "GO:0045453", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00399_MESH_D010001_1", "DB00282_MESH_C562390_1", "DB06255_MESH_C562390_1", "DB00153_MESH_D010024_1", "DB00282_MESH_D010001_1", "DB00399_MESH_C562390_1", "DB00153_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000092", "original_object": "GO:0045453"}
{"subject": "GO:0098684", "predicate": "biolink:overlaps", "object": "UBERON:0004456", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0098684", "original_object": "UBERON:0004456"}
{"subject": "NCBIGene:153", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18357", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00571_MESH_D002312_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08588", "original_object": "MESH:D009638"}
{"subject": "NCBIGene:153", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18357", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00571_MESH_D002312_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08588", "original_object": "MESH:D009638"}
{"subject": "NCBIGene:153", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18357", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00571_MESH_D002312_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08588", "original_object": "MESH:D009638"}
{"subject": "NCBIGene:153", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18357", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00571_MESH_D002312_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08588", "original_object": "MESH:D009638"}
{"subject": "GO:0004505", "predicate": "biolink:affects", "object": "CHEBI:28044", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00360_MESH_D010661_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0004505", "original_object": "CHEBI:28044"}
{"object": "GO:0043039", "predicate": "biolink:has_participant", "subject": "GO:0006412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13092_MESH_D012852_1", "DB13092_MESH_D002602_1", "DB13092_MESH_D000073605_1", "DB13092_MESH_D015001_1", "DB13092_MESH_D002006_1", "DB13092_MESH_D013587_1", "DB13092_MESH_D006100_1", "DB13092_MESH_D011014_1", "DB13092_MESH_D011778_1", "DB13092_MESH_D003235_1", "DB13092_MESH_D000196_1", "DB13092_MESH_D012061_1", "DB13092_MESH_D009956_1", "DB13092_MESH_D010612_1", "DB13092_MESH_D000881_1", "DB13092_MESH_D014552_1", "DB13092_MESH_D012373_1", "DB13092_MESH_D006069_1", "DB13092_MESH_D013203_1", "DB13092_MESH_D008219_1", "DB13092_MESH_D000152_1", "DB13092_MESH_D001991_1", "DB13092_MESH_D014141_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0043039", "original_subject": "GO:0006412"}
{"subject": "UBERON:0001003", "predicate": "biolink:positively_correlated_with", "object": "HP:0040189", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01243_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001003", "original_object": "HP:0040189"}
{"subject": "UNII:1B56C968OA", "predicate": "biolink:affects", "object": "CL:0000057", "qualified_predicate": "biolink:causes", "subject_context_qualifier": "UniProtKB:P09619", "anatomical_context_qualifier": "UMLS:C1512505", "disease_context_qualifier": "MONDO:0007254", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:31419632"], "primary_knowledge_source": "infores:ccidb", "original_subject": "UNII:1B56C968OA", "original_object": "CL:0000057"}
{"subject": "CHEBI:17650", "predicate": "biolink:produces", "object": "CHEBI:17650", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00741_MESH_D009140_1", "DB00741_MESH_D013966_1", "DB00741_MESH_D003873_1", "DB00741_MESH_D012507_1", "DB00741_MESH_D001327_1", "DB00741_MESH_D011565_1", "DB00741_MESH_D015535_1", "DB00741_MESH_D011015_1", "DB00741_MESH_D052256_1", "DB00741_MESH_D001249_1", "DB00741_MESH_D000309_1", "DB00741_MESH_D000744_1", "DB00741_MESH_D015210_1", "DB00741_MESH_D003874_1", "DB00741_MESH_D008228_1", "DB00741_MESH_D000224_1", "DB00741_MESH_D005076_1", "DB00741_MESH_D013585_1", "DB00741_MESH_C562390_1", "DB00741_MESH_D001607_1", "DB00741_MESH_D013167_1", "DB00741_MESH_D002062_1", "DB00741_MESH_D001172_1", "DB00741_MESH_D009182_1", "DB00741_MESH_D012713_1", "DB00741_MESH_D006484_1", "DB00741_MESH_D010392_1", "DB00741_MESH_D003876_1", "DB00741_MESH_D001929_1", "DB00741_MESH_D011538_1", "DB00741_MESH_D065631_1", "DB00741_MESH_D008180_1", "DB00741_MESH_D005128_1", "DB00741_MESH_D003877_1", "DB00741_MESH_D004892_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006854", "original_object": "MESH:C007133"}
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{"object": "CL:0002541", "predicate": "biolink:has_part", "subject": "GO:0042600", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "CL:0002541", "original_subject": "UBERON:0003124"}
{"subject": "UBERON:0011302", "predicate": "biolink:composed_primarily_of", "object": "CHEBI:18246", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0011302", "original_object": "CHEBI:18246"}
{"subject": "CHEBI:90936", "predicate": "biolink:related_to", "object": "CHEBI:90937", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:90936", "original_object": "CHEBI:90937"}
{"subject": "MESH:C044919", "predicate": "biolink:capable_of", "object": "GO:0046911", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08826_MESH_D017086_1", "DB08826_MESH_D019190_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C044919", "original_object": "GO:0046911"}
{"subject": "CL:1001319", "predicate": "biolink:develops_from", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:1001319", "original_object": "NCBITaxon:6072"}
{"subject": "UBERON:0008867", "predicate": "biolink:develops_from", "object": "CL:0007001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0008867", "original_object": "CL:0007001"}
{"subject": "GO:0042600", "predicate": "biolink:coexists_with", "object": "UBERON:0000922", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003124", "original_object": "UBERON:0000922"}
{"subject": "CL:0000317", "predicate": "biolink:affects", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00655_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "CL:0000317", "original_object": "MESH:D012629"}
{"subject": "GO:0005152", "predicate": "biolink:precedes", "object": "GO:0019221", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005152", "original_object": "GO:0019221"}
{"subject": "REACT:R-HSA-166208", "predicate": "biolink:positively_correlated_with", "object": "HP:0031377", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00179_MESH_D055623_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-166208", "original_object": "HP:0031377"}
{"subject": "CHEBI:32301", "predicate": "biolink:affects", "object": "CHEBI:29103", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:32301", "original_object": "CHEBI:29103"}
{"subject": "CHEBI:16933", "predicate": "biolink:regulates", "object": "GO:0009277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00681_MESH_D002179_1", "DB00681_MESH_D012852_1", "DB00681_MESH_D058387_1", "DB00681_MESH_D001228_1", "DB00681_MESH_D001991_1", "DB00681_MESH_D003235_1", "DB00681_MESH_D000152_1", "DB00681_MESH_D059413_1", "DB00681_MESH_D014552_1", "DB00681_MESH_D007896_1", "DB00681_MESH_D010612_1", "DB00681_MESH_D003047_1", "DB00681_MESH_D006660_1", "DB00681_MESH_D055744_1", "DB00681_MESH_D007898_1", "DB00681_MESH_D001759_1", "DB00681_MESH_D016921_1", "DB00681_MESH_D009091_1", "DB00681_MESH_D011014_1", "DB00681_MESH_D002180_1", "DB00681_MESH_C536777_1", "DB00681_MESH_D002177_1", "DB00681_MESH_D003453_1", "DB00681_MESH_D003963_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D004875", "original_object": "GO:0009277"}
{"subject": "CHEBI:16521", "predicate": "biolink:negatively_correlated_with", "object": "GO:0009277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06636_MESH_D009091_1", "DB06636_MESH_D001228_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16521", "original_object": "GO:0009277"}
{"object": "GO:0016056", "predicate": "biolink:causes", "subject": "PR:000001245", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0016056", "original_subject": "PR:000001245"}
{"subject": "UMLS:C0282629", "predicate": "biolink:in_taxon", "object": "NCBITaxon:3052230", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09296_MESH_D019698_1", "DB11613_MESH_D019698_1", "DB09102_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0282629", "original_object": "NCBITaxon:3052230"}
{"subject": "UMLS:C0227980", "predicate": "biolink:subclass_of", "object": "MONDO:0004767", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C128598", "original_object": "NCIT:C12787"}
{"subject": "GO:0055070", "predicate": "biolink:related_to", "object": "CHEBI:23378", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0055070", "original_object": "CHEBI:23378"}
{"subject": "UBERON:0003615", "predicate": "biolink:subclass_of", "object": "GO:0071953", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003615", "original_object": "UBERON:0002521"}
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{"subject": "NCBIGene:351", "predicate": "biolink:acts_upstream_of_positive_effect", "object": "GO:0031583", "primary_knowledge_source": "infores:goa", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:18723082"], "original_subject": "UniProtKB:P05067", "original_object": "GO:0031583"}
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{"subject": "UBERON:0009778", "predicate": "biolink:related_to", "object": "NCBITaxon:6072", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0009778", "original_object": "NCBITaxon:6072"}
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{"subject": "PANTHER.FAMILY:PTHR18966", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:18237", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00463_MESH_D004827_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PANTHER.FAMILY:PTHR18966", "original_object": "MESH:D018698"}
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{"subject": "MESH:C048833", "predicate": "biolink:affects", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00745_MESH_D009290_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:C048833", "original_object": "MESH:D006632"}
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{"subject": "GO:0004857", "predicate": "biolink:occurs_in", "object": "NCBITaxon:55193", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01188_MESH_D012628_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0004857", "original_object": "NCBITaxon:55193"}
{"subject": "CHEBI:31346", "predicate": "biolink:positively_correlated_with", "object": "NCIT:C3236", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:20368128"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D002133", "original_object": "MESH:D008679"}
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{"subject": "MONDO:0006789", "predicate": "biolink:affects", "object": "PR:000049996", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0410288", "original_object": "PR:000049996"}
{"subject": "MONDO:0020679", "predicate": "biolink:has_participant", "object": "UBERON:0001756", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0020679", "original_object": "UBERON:0001756"}
{"subject": "REACT:R-HSA-418594", "predicate": "biolink:negatively_correlated_with", "object": "GO:0061533", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00454_MESH_D010146_1", "DB00454_MESH_D048949_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-418594", "original_object": "GO:0061533"}
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{"subject": "CHEMBL.COMPOUND:CHEMBL1585396", "predicate": "biolink:associated_with_increased_likelihood_of", "object": "MONDO:0024337", "primary_knowledge_source": "infores:cebs", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["TR:TR-179"], "anatomical_context_qualifier": "UBERON:0001255", "sex_qualifier": "female", "species_context_qualifier": "NCBITaxon:10116", "population_context_qualifier": "RGD:13506918", "original_subject": "INCHIKEY:LNHURPJLTHSVMU-SFECMWDFSA-N", "original_object": "MONDO:0024337"}
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{"subject": "CHEBI:63452", "predicate": "biolink:negatively_correlated_with", "object": "REACT:R-HSA-9607240", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06595_MESH_D034721_1", "DB06595_MESH_D015470_1", "DB06595_MESH_D007946_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C059539", "original_object": "REACT:R-HSA-9607240"}
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{"subject": "CHEBI:9328", "predicate": "biolink:negatively_correlated_with", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00359_MESH_D003093_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D013411", "original_object": "GO:0006954"}
{"subject": "CHEBI:36161", "predicate": "biolink:disrupts", "object": "NCBITaxon:5855", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01611_MESH_D016780_1", "DB00608_MESH_D016780_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:36161", "original_object": "NCBITaxon:5855"}
{"subject": "UBERON:0002439", "predicate": "biolink:regulates", "object": "MONDO:0007186", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00604_MESH_D005764_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UBERON:0002439", "original_object": "MESH:D005764"}
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{"subject": "MESH:C002070", "predicate": "biolink:decreases_sensitivity_to", "object": "NCBIGene:5744", "primary_knowledge_source": "infores:ctd", "description": "decreases response to", "taxon": "9606", "publications": ["PMID:24463094"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C002070", "original_object": "NCBIGENE:5744"}
{"subject": "CHEBI:79736", "predicate": "biolink:affects", "object": "MESH:D003643", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:22419121"], "knowledge_level": "prediction", "agent_type": "not_provided", "original_subject": "MESH:D015039", "original_object": "MESH:D003643"}
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{"subject": "CL:2000060", "predicate": "biolink:develops_from", "object": "GO:0042600", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:2000060", "original_object": "UBERON:0003124"}
{"subject": "NCBIGene:7276", "predicate": "biolink:enables", "object": "GO:0042802", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05352_MESH_D000686_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P02766", "original_object": "GO:0042802"}
{"subject": "NCBIGene:7276", "predicate": "biolink:enables", "object": "GO:0042802", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05352_MESH_D000686_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P02766", "original_object": "GO:0042802"}
{"subject": "GO:0005183", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002146", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00624_MESH_D007006_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005183", "original_object": "MESH:D007006"}
{"subject": "GO:0061805", "predicate": "biolink:related_to", "object": "GO:0000092", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0061805", "original_object": "GO:0000092"}
{"subject": "GO:0042983", "predicate": "biolink:has_output", "object": "PR:000004168", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042983", "original_object": "PR:000004168"}
{"subject": "MONDO:0005469", "predicate": "biolink:occurs_in", "object": "MONDO:0005180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06262_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001278", "original_object": "MESH:D010300"}
{"subject": "GO:0006590", "predicate": "biolink:affects", "object": "CHEBI:60311", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00763_MESH_D006980_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0006590", "original_object": "MESH:D013963"}
{"subject": "CL:0000232", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002280", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00158_MESH_D018798_1", "DB00016_MESH_D000740_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000232", "original_object": "HP:0001903"}
{"subject": "UBERON:0002046", "predicate": "biolink:related_to", "object": "CHEBI:3306", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002046", "original_object": "CHEBI:3306"}
{"subject": "CHEBI:24873", "predicate": "biolink:has_part", "object": "CHEBI:18248", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:24873", "original_object": "CHEBI:18248"}
{"subject": "NCBIGene:3554", "predicate": "biolink:affects", "object": "UMLS:C1301034", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "pancreatic fibrogenesis", "causal_mechanism_qualifier": "activation", "subject_context_qualifier": "UniProtKB:P18510", "anatomical_context_qualifier": "UMLS:C1301034", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:28514653"], "primary_knowledge_source": "infores:ccidb", "original_subject": "UniProtKB:P14778", "original_object": "UMLS:C1301034"}
{"subject": "NCBIGene:3554", "predicate": "biolink:affects", "object": "UMLS:C1301034", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "pancreatic fibrogenesis", "causal_mechanism_qualifier": "activation", "subject_context_qualifier": "UniProtKB:P18510", "anatomical_context_qualifier": "UMLS:C1301034", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:28514653"], "primary_knowledge_source": "infores:ccidb", "original_subject": "UniProtKB:P14778", "original_object": "UMLS:C1301034"}
{"subject": "UBERON:0006440", "predicate": "biolink:homologous_to", "object": "UBERON:0006435", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0006440", "original_object": "UBERON:0006435"}
{"subject": "GO:0097272", "predicate": "biolink:preventative_for_condition", "object": "HP:0001987", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00994_MESH_D006501_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0097272", "original_object": "HP:0001987"}
{"subject": "GO:0000785", "predicate": "biolink:correlated_with", "object": "GO:0032774", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06810_MESH_D013736_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000785", "original_object": "GO:0032774"}
{"subject": "MESH:D053260", "predicate": "biolink:negatively_correlated_with", "object": "EFO:0004344", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:33905944"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D053260", "original_object": "MESH:D001724"}
{"subject": "GO:0005248", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0005027", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05541_MESH_D004828_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005248", "original_object": "HP:0001250"}
{"subject": "UBERON:0022282", "predicate": "biolink:composed_primarily_of", "object": "CHEBI:18059", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0022282", "original_object": "CHEBI:18059"}
{"subject": "GO:0005739", "predicate": "biolink:located_in", "object": "CL:0000198", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06774_MESH_D051474_1", "DB06774_MESH_D001416_1", "DB06774_MESH_D009437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005739", "original_object": "CL:0000198"}
{"subject": "GO:0007274", "predicate": "biolink:predisposes_to_condition", "object": "HP:0003690", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00536_MESH_D015624_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007274", "original_object": "HP:0003690"}
{"subject": "MESH:D005744", "predicate": "biolink:contributes_to", "object": "MONDO:0001126", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00940_MESH_D013276_1", "DB04843_MESH_D013276_1", "DB00448_MESH_D013276_1", "DB00585_MESH_D013276_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005744", "original_object": "MESH:D013276"}
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{"subject": "GO:0003990", "predicate": "biolink:affects", "object": "CHEBI:15355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01057_MESH_D005901_1", "DB01057_MESH_D005902_1", "DB01057_MESH_D000080362_1", "DB01057_MESH_D004948_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0003990", "original_object": "MESH:D000109"}
{"subject": "CHEBI:134738", "predicate": "biolink:chemically_similar_to", "object": "CHEBI:67079", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06685_MESH_D020529_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C476223", "original_object": "CHEBI:67079"}
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{"subject": "CHEBI:17855", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:47774", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08949_MESH_D006950_1", "DB08949_MESH_D006937_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D014280", "original_object": "MESH:D008078"}
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{"subject": "CHEBI:2682", "predicate": "biolink:regulates", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00681_MESH_D002179_1", "DB00681_MESH_D012852_1", "DB00681_MESH_D058387_1", "DB00681_MESH_D001228_1", "DB00681_MESH_D001991_1", "DB00681_MESH_D003235_1", "DB00681_MESH_D000152_1", "DB00681_MESH_D059413_1", "DB00681_MESH_D014552_1", "DB00681_MESH_D007896_1", "DB00681_MESH_D010612_1", "DB00681_MESH_D003047_1", "DB00681_MESH_D006660_1", "DB00681_MESH_D055744_1", "DB00681_MESH_D007898_1", "DB00681_MESH_D001759_1", "DB00681_MESH_D016921_1", "DB00681_MESH_D009091_1", "DB00681_MESH_D011014_1", "DB00681_MESH_D002180_1", "DB00681_MESH_C536777_1", "DB00681_MESH_D002177_1", "DB00681_MESH_D003453_1", "DB00681_MESH_D003963_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D000666", "original_object": "MESH:D004875"}
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{"subject": "UBERON:0001017", "predicate": "biolink:correlated_with", "object": "PANTHER.FAMILY:PTHR46987", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00623_MESH_D011618_1", "DB00623_MESH_D012559_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001017", "original_object": "PANTHER.FAMILY:PTHR46987"}
{"subject": "NCBIGene:152", "predicate": "biolink:correlated_with", "object": "GO:0061529", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09304_MESH_D003866_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P18825", "original_object": "GO:0061529"}
{"subject": "NCBIGene:152", "predicate": "biolink:correlated_with", "object": "GO:0061529", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09304_MESH_D003866_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P18825", "original_object": "GO:0061529"}
{"subject": "MONDO:0004934", "predicate": "biolink:subclass_of", "object": "UBERON:0002384", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C13184", "original_object": "NCIT:C12374"}
{"subject": "UMLS:C1676737", "predicate": "biolink:positively_correlated_with", "object": "HP:0025249", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00799_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C1676737", "original_object": "HP:0025249"}
{"subject": "UMLS:C0012860", "predicate": "biolink:positively_correlated_with", "object": "GO:0006915", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00694_MESH_D012514_1", "DB01177_MESH_D015473_1", "DB00694_MESH_D015470_1", "DB01177_MESH_D015470_1", "DB00694_MESH_D007948_1", "DB00694_MESH_D015473_1", "DB00694_MESH_D004915_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004249", "original_object": "GO:0006915"}
{"subject": "UMLS:C0657912", "predicate": "biolink:causes", "object": "GO:0042697", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00230", "original_object": "UMLS:C0025320"}
{"subject": "MONDO:0100311", "predicate": "biolink:has_participant", "object": "UBERON:0001032", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0100311", "original_object": "UBERON:0001032"}
{"subject": "NCBIGene:6257", "predicate": "biolink:negatively_correlated_with", "object": "REACT:R-HSA-181438", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00799_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P28702", "original_object": "REACT:R-HSA-181438"}
{"subject": "NCBIGene:6257", "predicate": "biolink:negatively_correlated_with", "object": "REACT:R-HSA-181438", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00799_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P28702", "original_object": "REACT:R-HSA-181438"}
{"subject": "GO:0051607", "predicate": "biolink:affects", "object": "NCBITaxon:10566", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00724_MESH_D003218_1", "DB00724_MESH_D014860_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0051607", "original_object": "NCBITaxon:10566"}
{"subject": "CHEBI:3638", "predicate": "biolink:negatively_correlated_with", "object": "NCBIGene:54106", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00608_MESH_D008180_1", "DB00608_MESH_D008179_1", "DB00608_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002738", "original_object": "UniProtKB:Q9NR96"}
{"subject": "CHEBI:3638", "predicate": "biolink:negatively_correlated_with", "object": "NCBIGene:54106", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00608_MESH_D008180_1", "DB00608_MESH_D008179_1", "DB00608_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002738", "original_object": "UniProtKB:Q9NR96"}
{"subject": "CHEBI:3638", "predicate": "biolink:negatively_correlated_with", "object": "NCBIGene:54106", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00608_MESH_D008180_1", "DB00608_MESH_D008179_1", "DB00608_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002738", "original_object": "UniProtKB:Q9NR96"}
{"subject": "CHEBI:3638", "predicate": "biolink:negatively_correlated_with", "object": "NCBIGene:54106", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00608_MESH_D008180_1", "DB00608_MESH_D008179_1", "DB00608_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002738", "original_object": "UniProtKB:Q9NR96"}
{"object": "UBERON:0002038", "predicate": "biolink:disrupts", "subject": "MONDO:0001945", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00915_MESH_D010301_1", "DB00245_MESH_D010301_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UBERON:0002038", "original_subject": "MESH:D010301"}
{"subject": "UNII:T472P45MG6", "predicate": "biolink:treats", "object": "HP:0041143", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:5024", "original_object": "UMLS:C0040185"}
{"subject": "MONDO:0045058", "predicate": "biolink:related_to", "object": "GO:0051458", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0045058", "original_object": "GO:0051458"}
{"subject": "CL:0000061", "predicate": "biolink:produces", "object": "UBERON:0001753", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000061", "original_object": "UBERON:0001753"}
{"subject": "CHEBI:41977", "predicate": "biolink:affects", "object": "GO:0032993", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00694_MESH_D012514_1", "DB00694_MESH_D015470_1", "DB00694_MESH_D007948_1", "DB00694_MESH_D015473_1", "DB00694_MESH_D004915_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D003630", "original_object": "GO:0032993"}
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{"subject": "GO:0071993", "predicate": "biolink:has_input", "object": "CHEBI:131728", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071993", "original_object": "CHEBI:131728"}
{"subject": "UBERON:0001798", "predicate": "biolink:composed_primarily_of", "object": "UBERON:0001797", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001798", "original_object": "UBERON:0001797"}
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{"subject": "GO:1990231", "predicate": "biolink:capable_of", "object": "GO:0060337", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:1990231", "original_object": "GO:0060337"}
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{"subject": "CHEBI:7660", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002180_1", "DB00646_MESH_D002179_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009761", "original_object": "CHEBI:16933"}
{"subject": "CHEBI:7660", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002180_1", "DB00646_MESH_D002179_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009761", "original_object": "CHEBI:16933"}
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{"subject": "CHEBI:15422", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5661", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05630_MESH_D007896_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000255", "original_object": "NCBITaxon:5661"}
{"subject": "CHEBI:15422", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5661", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05630_MESH_D007896_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000255", "original_object": "NCBITaxon:5661"}
{"subject": "NCBIGene:3641571", "predicate": "biolink:produces", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01263_MESH_D009181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P10613", "original_object": "MESH:D004875"}
{"subject": "NCBIGene:3641571", "predicate": "biolink:produces", "object": "CHEBI:16933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01263_MESH_D009181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P10613", "original_object": "MESH:D004875"}
{"subject": "GO:0030520", "predicate": "biolink:treats", "object": "MONDO:0001196", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01708_MESH_D004414_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0030520", "original_object": "MESH:D004414"}
{"subject": "NCBIGene:7442", "predicate": "biolink:regulates", "object": "CL:0000197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00405_MESH_D011537_1", "DB01084_MESH_D011537_1", "DB00557_MESH_D011537_1", "DB06691_MESH_D011537_1", "DB09555_MESH_D011537_1", "DB01114_MESH_D011537_1", "DB08799_MESH_D011537_1", "DB00434_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:Q8NER1", "original_object": "CL:0000197"}
{"subject": "NCBIGene:7442", "predicate": "biolink:regulates", "object": "CL:0000197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00405_MESH_D011537_1", "DB01084_MESH_D011537_1", "DB00557_MESH_D011537_1", "DB06691_MESH_D011537_1", "DB09555_MESH_D011537_1", "DB01114_MESH_D011537_1", "DB08799_MESH_D011537_1", "DB00434_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:Q8NER1", "original_object": "CL:0000197"}
{"subject": "CHEBI:190303", "predicate": "biolink:subclass_of", "object": "HP:0000118", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:190303", "original_object": "HP:0000118"}
{"subject": "CHEBI:30746", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:15428", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03793_MESH_D022124_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D019817", "original_object": "MESH:D005998"}
{"subject": "CHEBI:30746", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:15428", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03793_MESH_D022124_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D019817", "original_object": "MESH:D005998"}
{"subject": "CL:0000819", "predicate": "biolink:related_to", "object": "NCBITaxon:1", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000819", "original_object": "NCBITaxon:1"}
{"subject": "NCBIGene:3352", "predicate": "biolink:affects", "object": "UBERON:0001645", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00918_MESH_D008881_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:P28221", "original_object": "UBERON:0001645"}
{"subject": "NCBIGene:3352", "predicate": "biolink:affects", "object": "UBERON:0001645", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00918_MESH_D008881_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:P28221", "original_object": "UBERON:0001645"}
{"subject": "NCBIGene:2131", "predicate": "biolink:acts_upstream_of_or_within_positive_effect", "object": "GO:0007166", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "automated_agent", "original_subject": "UniProtKB:Q16394", "original_object": "GO:0007166"}
{"subject": "NCBIGene:2131", "predicate": "biolink:acts_upstream_of_or_within_positive_effect", "object": "GO:0007166", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "automated_agent", "original_subject": "UniProtKB:Q16394", "original_object": "GO:0007166"}
{"object": "GO:0004714", "predicate": "biolink:has_participant", "subject": "REACT:R-HSA-74713", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09564_MESH_D003920_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0004714", "original_subject": "REACT:R-HSA-74713"}
{"subject": "NCBIGene:1813", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01618_MESH_D012559_1", "DB11757_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P14416", "original_object": "MESH:D004298"}
{"subject": "NCBIGene:1813", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01618_MESH_D012559_1", "DB11757_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P14416", "original_object": "MESH:D004298"}
{"subject": "REACT:R-HSA-381377", "predicate": "biolink:affects", "object": "UMLS:C0334227", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "bone metastasis", "causal_mechanism_qualifier": "activation", "disease_context_qualifier": "MONDO:0008315", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:33731701"], "primary_knowledge_source": "infores:ccidb", "original_subject": "REACT:R-HSA-381377", "original_object": "UMLS:C0334227"}
{"subject": "GO:0051381", "predicate": "biolink:regulates", "object": "GO:0023041", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08799_MESH_D012912_1", "DB00434_MESH_D012912_2", "DB00637_MESH_D012912_1", "DB09488_MESH_D012912_1", "DB00950_MESH_D012912_1", "DB00434_MESH_D012912_1", "DB00341_MESH_D012912_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0051381", "original_object": "GO:0023041"}
{"subject": "GO:0000380", "predicate": "biolink:produces", "object": "UniProtKB:B4DP61", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13161_MESH_D009134_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000380", "original_object": "UniProtKB:B4DP61"}
{"subject": "NCBIGene:5578", "predicate": "biolink:contributes_to", "object": "GO:0051823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D001714_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P17252", "original_object": "GO:0051823"}
{"subject": "NCBIGene:5578", "predicate": "biolink:contributes_to", "object": "GO:0051823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D001714_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P17252", "original_object": "GO:0051823"}
{"subject": "CHEBI:34911", "predicate": "biolink:disrupts", "object": "UniProtKB:Q2VKV7", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04930_MESH_D012532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D026023", "original_object": "UniProtKB:Q2VKV7"}
{"subject": "CHEBI:34911", "predicate": "biolink:disrupts", "object": "UniProtKB:Q2VKV7", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04930_MESH_D012532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D026023", "original_object": "UniProtKB:Q2VKV7"}
{"subject": "CHEBI:18085", "predicate": "biolink:occurs_in", "object": "GO:0005764", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01279_MESH_D009087_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006025", "original_object": "GO:0005764"}
{"subject": "NCBIGene:2", "predicate": "biolink:affects", "object": "MESH:D028321", "primary_knowledge_source": "infores:ctd", "description": "decreases uptake of", "taxon": "9606", "publications": ["PMID:27262837"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:2", "original_object": "MESH:D028321", "object_aspect_qualifier": "uptake", "object_direction_qualifier": "decreased", "qualified_predicate": "biolink:causes"}
{"subject": "NCBIGene:2", "predicate": "biolink:affects", "object": "MESH:D028321", "primary_knowledge_source": "infores:ctd", "description": "decreases uptake of", "taxon": "9606", "publications": ["PMID:27262837"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBIGENE:2", "original_object": "MESH:D028321", "object_aspect_qualifier": "uptake", "object_direction_qualifier": "decreased", "qualified_predicate": "biolink:causes"}
{"subject": "UBERON:0000176", "predicate": "biolink:causes", "object": "HP:0025095", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00972_MESH_D065631_1", "DB00972_MESH_D006255_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000176", "original_object": "HP:0025095"}
{"subject": "CHEBI:5790", "predicate": "biolink:regulates", "object": "UBERON:0001896", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00327_MESH_D003371_1", "DB00327_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D004091", "original_object": "UBERON:0001896"}
{"subject": "CHEBI:5790", "predicate": "biolink:regulates", "object": "UBERON:0001896", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00327_MESH_D003371_1", "DB00327_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D004091", "original_object": "UBERON:0001896"}
{"subject": "CHEBI:21553", "predicate": "biolink:correlated_with", "object": "NCBIGene:5310", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:18215696", "PMID:21389975"], "original_subject": "HMDB:HMDB0006029", "original_object": "OMIM:601313"}
{"subject": "CHEBI:21553", "predicate": "biolink:correlated_with", "object": "NCBIGene:5310", "primary_knowledge_source": "infores:hmdb", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:18215696", "PMID:21389975"], "original_subject": "HMDB:HMDB0006029", "original_object": "OMIM:601313"}
{"subject": "UBERON:0001090", "predicate": "biolink:has_part", "object": "CHEBI:16336", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001090", "original_object": "CHEBI:16336"}
{"subject": "UBERON:0001090", "predicate": "biolink:has_part", "object": "CHEBI:16336", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001090", "original_object": "CHEBI:16336"}
{"subject": "UBERON:4000115", "predicate": "biolink:has_part", "object": "CHEBI:52255", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:4000115", "original_object": "CHEBI:52255"}
{"subject": "HP:0032263", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005068", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00722_MESH_D009203_1", "DB00335_MESH_D009203_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0032263", "original_object": "MESH:D009203"}
{"subject": "CHEBI:77035", "predicate": "biolink:affects", "object": "UBERON:0016553", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00874_MESH_D012220_1", "DB00874_MESH_D065631_1", "DB00874_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D005100", "original_object": "UBERON:0016553"}
{"subject": "GO:0071159", "predicate": "biolink:affects", "object": "NCBIGene:7412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00806_MESH_D016491_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0071159", "original_object": "UniProtKB:P19320"}
{"subject": "GO:0071159", "predicate": "biolink:affects", "object": "NCBIGene:7412", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00806_MESH_D016491_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0071159", "original_object": "UniProtKB:P19320"}
{"subject": "CHEBI:18243", "predicate": "biolink:negatively_correlated_with", "object": "PUBCHEM.COMPOUND:16132350", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00937_MESH_D009765_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004298", "original_object": "MESH:D009478"}
{"subject": "CHEBI:18243", "predicate": "biolink:negatively_correlated_with", "object": "PUBCHEM.COMPOUND:16132350", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00937_MESH_D009765_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004298", "original_object": "MESH:D009478"}
{"subject": "UBERON:0005304", "predicate": "biolink:positively_correlated_with", "object": "GO:0050892", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08900_MESH_D012778_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0005304", "original_object": "GO:0050892"}
{"subject": "UBERON:0003092", "predicate": "biolink:has_part", "object": "PR:000027222", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0003092", "original_object": "PR:000027222"}
{"subject": "CHEBI:39867", "predicate": "biolink:causes", "object": "UMLS:C1868980", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00313", "original_object": "UMLS:C1868980"}
{"subject": "CHEBI:39867", "predicate": "biolink:causes", "object": "UMLS:C1868980", "primary_knowledge_source": "infores:sider", "aggregator_knowledge_source": ["infores:hetionet"], "knowledge_level": "not_provided", "agent_type": "not_provided", "original_subject": "DRUGBANK:DB00313", "original_object": "UMLS:C1868980"}
{"subject": "GO:0004714", "predicate": "biolink:regulates", "object": "NCBIGene:207", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01307_MESH_D003920_1", "DB01306_MESH_D003920_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004714", "original_object": "UniProtKB:P31749"}
{"subject": "NCBIGene:9378", "predicate": "biolink:acts_upstream_of", "object": "GO:0098990", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:P58400", "original_object": "GO:0098990"}
{"subject": "NCBIGene:9378", "predicate": "biolink:acts_upstream_of", "object": "GO:0098990", "primary_knowledge_source": "infores:goa", "knowledge_level": "prediction", "agent_type": "manual_validation_of_automated_agent", "original_subject": "UniProtKB:P58400", "original_object": "GO:0098990"}
{"subject": "UMLS:C0023775", "predicate": "biolink:disrupts", "object": "GO:0006811", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002180_1", "DB00646_MESH_D002179_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0023775", "original_object": "GO:0006811"}
{"subject": "UBERON:0001707", "predicate": "biolink:correlated_with", "object": "MONDO:0004979", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01410_MESH_D001249_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001707", "original_object": "MESH:D001249"}
{"subject": "CHEBI:63625", "predicate": "biolink:has_active_ingredient", "object": "PUBCHEM.COMPOUND:5481180", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00300_MESH_D019694_1", "DB00300_MESH_D015658_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000068698", "original_object": "MESH:C583447"}
{"subject": "UBERON:0001295", "predicate": "biolink:positively_correlated_with", "object": "MONDO:0021251", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00603_MESH_D016889_1", "DB00351_MESH_D016889_1", "DB00396_MESH_D016889_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001295", "original_object": "MESH:D016889"}
{"subject": "CHEBI:28786", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D012135", "primary_knowledge_source": "infores:ctd", "publications": ["PMID:11874814"], "knowledge_level": "statistical_association", "agent_type": "manual_agent", "original_subject": "MESH:D010269", "original_object": "MESH:D012135"}
{"subject": "GO:0071159", "predicate": "biolink:regulates", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04837_MESH_D065631_1", "DB04837_MESH_D012220_1", "DB00434_MESH_D065631_1", "DB01114_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0071159", "original_object": "GO:0006954"}
{"subject": "UMLS:C2607955", "predicate": "biolink:causes", "object": "GO:0008219", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C2607955", "original_object": "GO:0008219"}
{"subject": "NCBIGene:154", "predicate": "biolink:regulates", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01214_MESH_D009798_1", "DB01214_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P07550", "original_object": "UBERON:0001796"}
{"subject": "NCBIGene:154", "predicate": "biolink:regulates", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01214_MESH_D009798_1", "DB01214_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P07550", "original_object": "UBERON:0001796"}
{"subject": "CHEBI:30769", "predicate": "biolink:disrupts", "object": "UBERON:0000912", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09154_MESH_D003139_1", "DB09154_MESH_D012220_1", "DB09154_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000077559", "original_object": "UBERON:0000912"}
{"subject": "CHEBI:30769", "predicate": "biolink:disrupts", "object": "UBERON:0000912", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09154_MESH_D003139_1", "DB09154_MESH_D012220_1", "DB09154_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000077559", "original_object": "UBERON:0000912"}
{"subject": "CL:0005020", "predicate": "biolink:coexists_with", "object": "UBERON:0004536", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0005020", "original_object": "UBERON:0004536"}
{"object": "MONDO:0001380", "predicate": "biolink:has_part", "subject": "UBERON:0001255", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "NCIT:C12332", "original_subject": "NCIT:C12414"}
{"subject": "UBERON:0018687", "predicate": "biolink:located_in", "object": "GO:0005604", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0018687", "original_object": "GO:0005604"}
{"subject": "CHEBI:6437", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0020039", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1563", "original_object": "UMLS:C0020039"}
{"subject": "CHEBI:6437", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0020039", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:1563", "original_object": "UMLS:C0020039"}
{"subject": "NCBIGene:2554", "predicate": "biolink:capable_of", "object": "GO:0022851", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09166_MESH_D001008_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P14867", "original_object": "GO:0022851"}
{"subject": "HGNC.FAMILY:404", "predicate": "biolink:regulates", "object": "PANTHER.FAMILY:PTHR11716", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D009450_1", "DB01234_MESH_D007627_1", "DB01234_MESH_D016403_1", "DB01234_MESH_D000799_1", "DB01234_MESH_D065631_1", "DB01234_MESH_D012214_1", "DB01234_MESH_D012393_1", "DB01234_MESH_D003320_1", "DB01234_MESH_D003877_1", "DB01234_MESH_D008180_1", "DB01234_MESH_D014235_1", "DB00240_MESH_D003876_1", "DB01234_MESH_D001929_1", "DB01234_MESH_D013717_2", "DB01234_MESH_D014391_1", "DB01234_MESH_D010392_1", "DB01234_MESH_D008224_1", "DB01234_MESH_D000744_1", "DB01234_MESH_D009140_1", "DB01234_MESH_D013167_1", "DB01234_MESH_D009101_1", "DB00240_MESH_D011538_1", "DB01234_MESH_D013716_1", "DB01234_MESH_D011565_1", "DB01234_MESH_D016410_1", "DB01234_MESH_D003876_1", "DB01234_MESH_D014605_1", "DB01234_MESH_D016460_1", "DB00240_MESH_D005076_1", "DB01234_MESH_D012713_1", "DB01234_MESH_D003424_1", "DB01234_MESH_D005128_1", "DB01234_MESH_D010032_1", "DB01234_MESH_D003874_1", "DB01234_MESH_D003233_1", "DB01234_MESH_D003873_1", "DB01234_MESH_D011538_1", "DB01234_MESH_D009404_1", "DB01234_MESH_D007634_1", "DB01234_MESH_D012871_1", "DB01234_MESH_D012628_1", "DB00240_MESH_D012628_1", "DB01234_MESH_D011657_1", "DB01234_MESH_D015535_1", "DB01234_MESH_D002062_1", "DB01234_MESH_D001607_1", "DB00240_MESH_D016410_1", "DB01234_MESH_D006689_1", "DB01234_MESH_D007500_1", "DB00240_MESH_D008179_1", "DB01234_MESH_D002051_1", "DB01234_MESH_D009103_1", "DB01234_MESH_D015863_1", "DB00240_MESH_D003877_1", "DB01234_MESH_D005076_1", "DB01234_MESH_D013966_1", "DB01234_MESH_C562390_1", "DB01234_MESH_D009182_1", "DB01234_MESH_D012507_1", "DB01234_MESH_D008179_1", "DB01234_MESH_D008228_1", "DB01234_MESH_D001249_1", "DB01234_MESH_D029503_1", "DB01234_MESH_D007819_1", "DB01234_MESH_D001172_1", "DB01234_MESH_D009450_1", "DB01234_MESH_D004892_1", "DB01234_MESH_D015210_1", "DB01234_MESH_D015212_1", "DB00240_MESH_D016460_1", "DB01234_MESH_D014606_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "HGNC.FAMILY:404", "original_object": "PANTHER.FAMILY:PTHR11716"}
{"subject": "MONDO:0002012", "predicate": "biolink:causes", "object": "MONDO:0002320", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00115_MESH_D001361_1", "DB00115_MESH_D014806_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002912", "original_object": "HP:0000707"}
{"subject": "GO:0071420", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01075_MESH_D006255_1", "DB00748_MESH_D006255_1", "DB01075_MESH_D012223_1", "DB01075_MESH_D003233_1", "DB00748_MESH_D012223_1", "DB00748_MESH_D003139_1", "DB00748_MESH_D014581_1", "DB00748_MESH_D003233_2", "DB00748_MESH_D065631_1", "DB00748_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0071420", "original_object": "MESH:D006632"}
{"subject": "GO:0023041", "predicate": "biolink:negatively_correlated_with", "object": "MONDO:0002009", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00344_MESH_D003865_1", "DB06148_MESH_D003865_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0023041", "original_object": "MESH:D003865"}
{"subject": "GO:0019233", "predicate": "biolink:occurs_in", "object": "HP:0100607", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06691_MESH_D004412_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0019233", "original_object": "MESH:D004412"}
{"subject": "GO:0014046", "predicate": "biolink:located_in", "object": "UBERON:0001910", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06144_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0014046", "original_object": "UBERON:0001910"}
{"subject": "CHEBI:16113", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005098", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00175_MESH_D020521_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002784", "original_object": "MESH:D020521"}
{"subject": "PR:000050296", "predicate": "biolink:develops_from", "object": "CL:0000826", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "PR:000050296", "original_object": "CL:0000826"}
{"subject": "UBERON:0004128", "predicate": "biolink:causes", "object": "UBERON:0004880", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004128", "original_object": "UBERON:0004880"}
{"object": "GO:0031929", "predicate": "biolink:causes", "subject": "GO:0038201", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0031929", "original_subject": "GO:0038201"}
{"subject": "CHEBI:46345", "predicate": "biolink:has_active_ingredient", "object": "PUBCHEM.COMPOUND:10255482", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09256_MESH_D013274_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005472", "original_object": "MESH:C025635"}
{"subject": "CHEBI:16113", "predicate": "biolink:located_in", "object": "UBERON:0002110", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01586_MESH_D002769_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002784", "original_object": "UBERON:0002110"}
{"subject": "MONDO:0021042", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "UNII:C4V974V932", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6304244", "PMC:8278705", "PMC:6304244", "PMC:6304244", "PMC:8278705"], "tmkp_confidence_score": 0.6542058325883658, "sentences": "In vivo SPIO@DSPE-PEG/DOX/ICG NP treatment resulted in a remarkable antitumor effect against glioma as compared with all other groups examined.|NA|To conclude, we report in the present study that ICG/PTX@RGE-EV can function as a potential drug delivery system of ICG/PTX for treatment of glioma, as evidenced by its prolonged residence period in blood circulation, and increased accumulation in tumor, thereby promoting anti-tumor action and reducing toxicity (Fig.?8).|NA|These results suggest that the SPIO@DSPE-PEG/DOX/ICG NPs can not only function as a nanoprobe for MR and fluorescence bimodal imaging, but also as a vehicle to deliver chemotherapeutic drugs to the tumor site, to achieve the theranostic treatment of glioma.|NA|To evaluate the safety, toxicity, and side effects of SPIO@DSPE-PEG/DOX/ICG NPs within glioma-bearing rats during the treatment, H&E-stained sections from the heart, liver, spleen, lung, kidney, and muscle were examined (Figure S3).|NA|The results of our study first elucidated that the inhibitory impact of ICG/PTX@RGE-EV on glioma development via apoptosis promotion, which suggested that ICG/PTX@RGE-EV might eventually be employed clinically for the treatment of glioma.|NA", "tmkp_ids": ["tmkp:367807965a370eabc32394f2c49f101f00f2290a4462d07d233d45e57481bd47", "tmkp:a08ea6fd10f89987c1fc2202d2b91f5567b79d5b7420121740116322e905cebf", "tmkp:6d141174d57a39002d1519ef17f408852aeb7667cf8bb121947f1143762508ad", "tmkp:abbd396a87c661d1f63739faf637cfde9e9627d641d19196e5a662ea04d28014", "tmkp:fe258a3fd612c261ad52efc78173d03c54f9debde90f20d8791dbd9542740d2a"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "MONDO:0021042", "original_object": "DRUGBANK:DB16024"}
{"subject": "HP:0000616", "predicate": "biolink:negatively_correlated_with", "object": "HP:0007663", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01057_MESH_D000080362_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0000616", "original_object": "HP:0007663"}
{"subject": "MONDO:0003947", "predicate": "biolink:disrupts", "object": "GO:0023035", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0003947", "original_object": "GO:0023035"}
{"subject": "MESH:C006632", "predicate": "biolink:affects", "object": "CHEBI:26523", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01169_MESH_D015479_1", "DB01169_MESH_D015473_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:C006632", "original_object": "CHEBI:26523"}
{"subject": "UBERON:0000410", "predicate": "biolink:correlated_with", "object": "GO:0070254", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06767_MESH_D003371_1", "DB06767_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000410", "original_object": "GO:0070254"}
{"subject": "NCBIGene:153", "predicate": "biolink:affects", "object": "HGNC.FAMILY:53", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00187_MESH_D001281_1", "DB00187_MESH_D013617_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:P08588", "original_object": "HGNC.FAMILY:53"}
{"subject": "NCBIGene:153", "predicate": "biolink:affects", "object": "HGNC.FAMILY:53", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00187_MESH_D001281_1", "DB00187_MESH_D013617_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:P08588", "original_object": "HGNC.FAMILY:53"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0000403", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00443_MESH_D012536_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "UBERON:0000403"}
{"subject": "CHEBI:18361", "predicate": "biolink:regulates", "object": "CHEBI:52255", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05768_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "CHEBI:18361", "original_object": "CHEBI:52255"}
{"subject": "CHEBI:82405", "predicate": "biolink:regulates", "object": "NCBITaxon:1747", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09096_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D001585", "original_object": "NCBITaxon:1747"}
{"subject": "CHEBI:82405", "predicate": "biolink:regulates", "object": "NCBITaxon:1747", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09096_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D001585", "original_object": "NCBITaxon:1747"}
{"subject": "MONDO:0018310", "predicate": "biolink:disrupts", "object": "CL:0000453", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0018310", "original_object": "CL:0000453"}
{"subject": "CHEBI:65265", "predicate": "biolink:negatively_correlated_with", "object": "GO:0001696", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09481_MESH_D005764_1", "DB09481_MESH_D010437_1", "DB09481_MESH_D003248_1", "DB09481_MESH_D006356_1", "DB09481_MESH_D004415_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000863", "original_object": "GO:0001696"}
{"subject": "CHEBI:53667", "predicate": "biolink:affects", "object": "PANTHER.FAMILY:PTHR22935", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01140_MESH_D014069_1", "DB01140_MESH_D014552_1", "DB01140_MESH_D013203_1", "DB01140_MESH_D013290_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D002434", "original_object": "PANTHER.FAMILY:PTHR22935"}
{"subject": "NCBIGene:4509", "predicate": "biolink:genetically_associated_with", "object": "NCBIGene:4509", "primary_knowledge_source": "infores:uniprot", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC:7415", "original_object": "OMIM:516070"}
{"subject": "NCBIGene:4509", "predicate": "biolink:genetically_associated_with", "object": "NCBIGene:4509", "primary_knowledge_source": "infores:uniprot", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC:7415", "original_object": "OMIM:516070"}
{"subject": "NCBIGene:4509", "predicate": "biolink:genetically_associated_with", "object": "NCBIGene:4509", "primary_knowledge_source": "infores:uniprot", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC:7415", "original_object": "OMIM:516070"}
{"subject": "NCBIGene:4509", "predicate": "biolink:genetically_associated_with", "object": "NCBIGene:4509", "primary_knowledge_source": "infores:uniprot", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC:7415", "original_object": "OMIM:516070"}
{"subject": "UBERON:0034929", "predicate": "biolink:overlaps", "object": "CL:0000540", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0034929", "original_object": "CL:0000540"}
{"subject": "UBERON:0001913", "predicate": "biolink:has_part", "object": "CHEBI:18059", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001913", "original_object": "CHEBI:18059"}
{"subject": "MONDO:0005044", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005098", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00966_MESH_D020521_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006973", "original_object": "MESH:D020521"}
{"subject": "CHEBI:83379", "predicate": "biolink:has_part", "object": "CHEBI:83382", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:83379", "original_object": "CHEBI:83382"}
{"subject": "EFO:0020954", "predicate": "biolink:expressed_in", "object": "GO:0005615", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C101645", "original_object": "NCIT:C26055"}
{"subject": "UMLS:C0025241", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01042_MESH_D010051_1", "DB01042_MESH_D009101_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008558", "original_object": "MESH:D004247"}
{"subject": "CHEBI:32090", "predicate": "biolink:negatively_correlated_with", "object": "CHEBI:26519", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11656_MESH_D005756_1", "DB11656_MESH_D010437_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C052785", "original_object": "MESH:D005609"}
{"subject": "GO:0035240", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:18243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00420_MESH_D011618_1", "DB00420_MESH_D019958_1", "DB00420_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0035240", "original_object": "MESH:D004298"}
{"subject": "CHEBI:3209", "predicate": "biolink:affects", "object": "GO:0046323", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04830_MESH_D003924_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "MESH:D002026", "original_object": "GO:0046323"}
{"subject": "CHEBI:141517", "predicate": "biolink:capable_of", "object": "GO:0043129", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06439_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C016811", "original_object": "GO:0043129"}
{"subject": "CHEBI:39214", "predicate": "biolink:subclass_of", "object": "CHEBI:60004", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:39214", "original_object": "CHEBI:60004"}
{"subject": "NCBIGene:5241", "predicate": "biolink:correlated_with", "object": "UMLS:C0042404", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P06401", "original_object": "MESH:D014666"}
{"subject": "NCBIGene:5241", "predicate": "biolink:correlated_with", "object": "UMLS:C0042404", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D019584_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P06401", "original_object": "MESH:D014666"}
{"subject": "PUBCHEM.COMPOUND:26945", "predicate": "biolink:disrupts", "object": "CL:0000232", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12975_MESH_D016778_2", "DB12975_MESH_D016780_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D006427", "original_object": "CL:0000232"}
{"subject": "GO:0038169", "predicate": "biolink:regulates", "object": "MONDO:0019933", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06791_MESH_D000172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0038169", "original_object": "MESH:D000172"}
{"subject": "UBERON:0002242", "predicate": "biolink:has_part", "object": "CHEBI:18250", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002242", "original_object": "CHEBI:37397"}
{"subject": "UBERON:0002242", "predicate": "biolink:has_part", "object": "CHEBI:18250", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0002242", "original_object": "CHEBI:37397"}
{"subject": "GO:0034776", "predicate": "biolink:affects", "object": "GO:0007186", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09488_MESH_D003139_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "GO:0034776", "original_object": "GO:0007186"}
{"subject": "CHEBI:28939", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06151_MESH_D001987_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000111", "original_object": "GO:0006954"}
{"subject": "CHEBI:28939", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06151_MESH_D001987_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000111", "original_object": "GO:0006954"}
{"subject": "UNII:F85N2YHE4E", "predicate": "biolink:affects", "object": "GO:0006635", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09568_MESH_D015228_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "DRUGBANK:DB09568", "original_object": "GO:0006635"}
{"subject": "UBERON:8600029", "predicate": "biolink:contributes_to", "object": "GO:0042600", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:8600029", "original_object": "UBERON:0003124"}
{"subject": "CHEBI:77035", "predicate": "biolink:affects", "object": "GO:0120197", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06715_MESH_D003139_1", "DB06715_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "CHEBI:77035", "original_object": "GO:0120197"}
{"subject": "MESH:D044062", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB07615_MESH_D065631_2", "DB07615_MESH_D003876_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D044062", "original_object": "GO:0006954"}
{"subject": "GO:0060087", "predicate": "biolink:ameliorates_condition", "object": "HP:0001681", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01020_MESH_D000787_1", "DB00335_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0060087", "original_object": "MESH:D000787"}
{"object": "UBERON:0001062", "predicate": "biolink:has_part", "subject": "NCBITaxon:7227", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "FBbt:10000000", "original_subject": "NCBITaxon:7227"}
{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "PANTHER.FAMILY:PTHR10078", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08895_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "PANTHER.FAMILY:PTHR10078"}
{"subject": "NCBIGene:4306", "predicate": "biolink:positively_correlated_with", "object": "HGNC.FAMILY:1203", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D065446_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08235", "original_object": "HGNC.FAMILY:1203"}
{"subject": "NCBIGene:4306", "predicate": "biolink:positively_correlated_with", "object": "HGNC.FAMILY:1203", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01395_MESH_D065446_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08235", "original_object": "HGNC.FAMILY:1203"}
{"subject": "HP:0002487", "predicate": "biolink:affects", "object": "HP:0032155", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00771_MESH_D043183_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "MESH:D013035", "original_object": "HP:0032155"}
{"subject": "UBERON:0012281", "predicate": "biolink:subclass_of", "object": "MONDO:0002260", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C77610", "original_object": "NCIT:C32132"}
{"subject": "HGNC.FAMILY:245", "predicate": "biolink:negatively_correlated_with", "object": "GO:0060004", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00318_MESH_D003371_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:245", "original_object": "GO:0060004"}
{"subject": "CHEBI:35441", "predicate": "biolink:ameliorates_condition", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03255_MESH_D011537_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000890", "original_object": "MESH:D011537"}
{"subject": "UMLS:C0042774", "predicate": "biolink:positively_correlated_with", "object": "UMLS:C0282629", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09296_MESH_D019698_1", "DB11613_MESH_D019698_1", "DB09102_MESH_D019698_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UMLS:C0042774", "original_object": "UMLS:C0282629"}
{"subject": "UBERON:0010210", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0000831", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00266_MESH_D013927_1", "DB00946_MESH_D013927_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010210", "original_object": "MESH:D013927"}
{"subject": "GO:0008237", "predicate": "biolink:affects", "object": "GO:0031012", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00654_MESH_D009798_1", "DB00287_MESH_D005902_1", "DB08819_MESH_D005902_1", "DB00654_MESH_D005902_1", "DB00287_MESH_D009798_1", "DB08819_MESH_D009798_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "abundance", "original_subject": "GO:0008237", "original_object": "GO:0031012"}
{"subject": "CL:0001074", "predicate": "biolink:has_part", "object": "NCBIGene:4684", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0001074", "original_object": "PR:P13591"}
{"subject": "CHEBI:6805", "predicate": "biolink:similar_to", "object": "CHEBI:133011", "primary_knowledge_source": "infores:hetionet", "knowledge_level": "not_provided", "agent_type": "not_provided", "hetio_source": ["Dice similarity of ECFPs"], "original_subject": "DRUGBANK:DB00931", "original_object": "DRUGBANK:DB00595"}
{"subject": "NCBIGene:153", "predicate": "biolink:regulates", "object": "GO:1990454", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00264_MESH_D054058_1", "DB00264_MESH_D009203_1", "DB00264_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P08588", "original_object": "GO:1990454"}
{"subject": "NCBIGene:153", "predicate": "biolink:regulates", "object": "GO:1990454", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00264_MESH_D054058_1", "DB00264_MESH_D009203_1", "DB00264_MESH_D000787_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "UniProtKB:P08588", "original_object": "GO:1990454"}
{"subject": "CHEBI:30031", "predicate": "biolink:affects", "object": "UMLS:C3891660", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "migration", "causal_mechanism_qualifier": "activation", "subject_context_qualifier": "UniProtKB:Q9BXA5", "anatomical_context_qualifier": "UMLS:C0334227", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:31735641"], "primary_knowledge_source": "infores:ccidb", "original_subject": "CHEBI:30031", "original_object": "UMLS:C3891660"}
{"subject": "MONDO:0044348", "predicate": "biolink:has_participant", "object": "CHEBI:35143", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MONDO:0044348", "original_object": "CHEBI:35143"}
{"subject": "GO:0030485", "predicate": "biolink:subclass_of", "object": "CL:0002320", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C13001", "original_object": "NCIT:C12555"}
{"subject": "CHEBI:18295", "predicate": "biolink:regulates", "object": "GO:0071159", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04837_MESH_D065631_1", "DB04837_MESH_D012220_1", "DB00434_MESH_D065631_1", "DB01114_MESH_D065631_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "MESH:D006632", "original_object": "GO:0071159"}
{"subject": "CHEBI:6942", "predicate": "biolink:produces", "object": "CL:0000346", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00350_MESH_D000505_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008914", "original_object": "CL:0000346"}
{"subject": "CHEBI:6942", "predicate": "biolink:produces", "object": "CL:0000346", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00350_MESH_D000505_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008914", "original_object": "CL:0000346"}
{"subject": "PUBCHEM.COMPOUND:10255482", "predicate": "biolink:disrupts", "object": "GO:0032774", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09256_MESH_D013274_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C025635", "original_object": "GO:0032774"}
{"subject": "CHEBI:32190", "predicate": "biolink:produces", "object": "CHEBI:9436", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11783_MESH_D006973_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C055603", "original_object": "MESH:C069156"}
{"subject": "GO:0007213", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:15355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00508_MESH_D011618_3", "DB00508_MESH_D011618_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007213", "original_object": "MESH:D000109"}
{"subject": "GO:0007213", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:15355", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00508_MESH_D011618_3", "DB00508_MESH_D011618_4"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007213", "original_object": "MESH:D000109"}
{"subject": "CHEBI:7959", "predicate": "biolink:capable_of", "object": "GO:0046911", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00859_MESH_D003555_2", "DB00859_MESH_D001172_2", "DB00859_MESH_D006527_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010396", "original_object": "GO:0046911"}
{"subject": "CHEBI:7959", "predicate": "biolink:capable_of", "object": "GO:0046911", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00859_MESH_D003555_2", "DB00859_MESH_D001172_2", "DB00859_MESH_D006527_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010396", "original_object": "GO:0046911"}
{"subject": "GO:0046930", "predicate": "biolink:located_in", "object": "GO:0030445", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00646_MESH_D002180_1", "DB00646_MESH_D002179_1", "DB00646_MESH_D002181_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0008915", "original_object": "GO:0030445"}
{"subject": "NCBITaxon:2", "predicate": "biolink:causes", "object": "HP:0200042", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05245_MESH_D012883_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCBITaxon:2", "original_object": "MESH:D012883"}
{"subject": "NCBIGene:7040", "predicate": "biolink:affects", "object": "REACT:R-HSA-381377", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activation", "subject_context_qualifier": "UniProtKB:P37173", "anatomical_context_qualifier": "UMLS:C0334227", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:33731701"], "primary_knowledge_source": "infores:ccidb", "original_subject": "UniProtKB:P01137", "original_object": "REACT:R-HSA-381377"}
{"subject": "NCBIGene:7040", "predicate": "biolink:affects", "object": "REACT:R-HSA-381377", "qualified_predicate": "biolink:causes", "object_aspect_qualifier": "activation", "subject_context_qualifier": "UniProtKB:P37173", "anatomical_context_qualifier": "UMLS:C0334227", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "publications": ["PMID:33731701"], "primary_knowledge_source": "infores:ccidb", "original_subject": "UniProtKB:P01137", "original_object": "REACT:R-HSA-381377"}
{"object": "MONDO:0006231", "predicate": "biolink:causes", "subject": "UBERON:0005409", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MONDO:0006231", "original_subject": "UBERON:0005409"}
{"subject": "UBERON:0000123", "predicate": "biolink:coexists_with", "object": "GO:0043209", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0000123", "original_object": "GO:0043209"}
{"subject": "GO:0016209", "predicate": "biolink:preventative_for_condition", "object": "HP:0025610", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00137_MESH_D000080343_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0016209", "original_object": "MESH:D000080343"}
{"subject": "GO:0042310", "predicate": "biolink:negatively_correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00449_MESH_D005902_1", "DB00668_MESH_D005902_2", "DB00668_MESH_D005902_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0042310", "original_object": "UBERON:0001796"}
{"subject": "CHEBI:65265", "predicate": "biolink:negatively_correlated_with", "object": "MESH:D005744", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB09104_MESH_D010437_1", "DB09104_MESH_D005764_1", "DB09104_MESH_D004415_1", "DB09104_MESH_D006356_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000863", "original_object": "MESH:D005744"}
{"subject": "MONDO:0016648", "predicate": "biolink:affects", "object": "HP:0002656", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002654", "original_object": "HP:0002656"}
{"subject": "NCBIGene:3565", "predicate": "biolink:genetically_associated_with", "object": "UMLS:C0035234", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:6014", "original_object": "UMLS:C0035234"}
{"subject": "NCBIGene:3565", "predicate": "biolink:genetically_associated_with", "object": "UMLS:C0035234", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:6014", "original_object": "UMLS:C0035234"}
{"subject": "HGNC.FAMILY:180", "predicate": "biolink:treats", "object": "HP:0000989", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00835_MESH_D011537_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:180", "original_object": "MESH:D011537"}
{"object": "GO:0051262", "predicate": "biolink:disrupts", "subject": "GO:0043243", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05352_MESH_D000686_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "GO:0051262", "original_subject": "GO:0043243"}
{"subject": "CHEBI:31889", "predicate": "biolink:negatively_correlated_with", "object": "UBERON:0001866", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12447_MESH_D000152_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C062127", "original_object": "UBERON:0001866"}
{"subject": "GO:0005618", "predicate": "biolink:positively_correlated_with", "object": "GO:0051301", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01000_MESH_D001991_1", "DB01000_MESH_D010612_1", "DB01000_MESH_D014552_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005618", "original_object": "GO:0051301"}
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{"subject": "NCBIGene:2099", "predicate": "biolink:directly_physically_interacts_with", "object": "CHEBI:50114", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04938_MESH_D004414_1", "DB00882_MESH_D007247_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P03372", "original_object": "MESH:D004967"}
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{"subject": "CHEBI:28694", "predicate": "biolink:positively_correlated_with", "object": "PANTHER.FAMILY:PTHR10078", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D003300", "original_object": "PANTHER.FAMILY:PTHR10078"}
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{"subject": "NCBIGene:847", "predicate": "biolink:genetically_associated_with", "object": "UMLS:C0022650", "primary_knowledge_source": "infores:disgenet", "aggregator_knowledge_source": ["infores:pharos"], "knowledge_level": "not_provided", "agent_type": "not_provided", "score": 0.3, "original_subject": "HGNC:1516", "original_object": "UMLS:C0022650"}
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{"subject": "GO:0141067", "predicate": "biolink:related_to", "object": "CHEBI:17997", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0141067", "original_object": "CHEBI:17997"}
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{"subject": "CHEBI:82720", "predicate": "biolink:preventative_for_condition", "object": "UMLS:C1320716", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4830", "original_object": "UMLS:C1320716"}
{"subject": "CHEBI:82720", "predicate": "biolink:preventative_for_condition", "object": "UMLS:C1320716", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4830", "original_object": "UMLS:C1320716"}
{"subject": "HP:0003536", "predicate": "biolink:affects", "object": "GO:0004333", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0003536", "original_object": "GO:0004333"}
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{"subject": "UMLS:C1517336", "predicate": "biolink:affects", "object": "NCBIGene:7015", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UMLS:C1517336", "original_object": "UniProtKB:O14746"}
{"subject": "UMLS:C1517336", "predicate": "biolink:affects", "object": "NCBIGene:7015", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06824_MESH_D002292_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UMLS:C1517336", "original_object": "UniProtKB:O14746"}
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{"subject": "HGNC.FAMILY:245", "predicate": "biolink:affects", "object": "CHEBI:16480", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00295_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "abundance", "original_subject": "HGNC.FAMILY:245", "original_object": "CHEBI:16480"}
{"subject": "CHEBI:15355", "predicate": "biolink:located_in", "object": "GO:0045202", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00843_MESH_D000544_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D000109", "original_object": "GO:0045202"}
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{"object": "CHEBI:4534", "predicate": "biolink:has_metabolite", "subject": "PUBCHEM.COMPOUND:174173", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01501_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:C100010", "original_subject": "MESH:C028792"}
{"object": "CHEBI:4534", "predicate": "biolink:has_metabolite", "subject": "PUBCHEM.COMPOUND:174173", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01501_MESH_D003967_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:C100010", "original_subject": "MESH:C028792"}
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{"subject": "CHEBI:17823", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:22984", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01436_MESH_D006961_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002117", "original_object": "MESH:D002118"}
{"subject": "CHEBI:17823", "predicate": "biolink:positively_correlated_with", "object": "CHEBI:22984", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01436_MESH_D006961_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002117", "original_object": "MESH:D002118"}
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{"subject": "CHEBI:4784", "predicate": "biolink:produces", "object": "UMLS:C0014027", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00584_MESH_D006973_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004656", "original_object": "MESH:D015773"}
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{"subject": "GO:0015842", "predicate": "biolink:positively_correlated_with", "object": "REACT:R-HSA-212676", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04844_MESH_D006816_1", "DB11915_MESH_D000071057_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0015842", "original_object": "REACT:R-HSA-212676"}
{"subject": "UMLS:C0032015", "predicate": "biolink:manifestation_of", "object": "MONDO:0005090", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00623_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D010907", "original_object": "MESH:D012559"}
{"subject": "GO:0004519", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00003_MESH_D003550_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0004519", "original_object": "MESH:D004247"}
{"subject": "HP:0002069", "predicate": "biolink:in_taxon", "object": "NCBITaxon:52283", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00431_MESH_D012532_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0002069", "original_object": "NCBITaxon:52283"}
{"subject": "NCBIGene:155", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:4846", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04861_MESH_D006973_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P13945", "original_object": "UniProtKB:P29474"}
{"subject": "NCBIGene:155", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:4846", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04861_MESH_D006973_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P13945", "original_object": "UniProtKB:P29474"}
{"subject": "NCBIGene:155", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:4846", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04861_MESH_D006973_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P13945", "original_object": "UniProtKB:P29474"}
{"subject": "NCBIGene:155", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:4846", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04861_MESH_D006973_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P13945", "original_object": "UniProtKB:P29474"}
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{"subject": "REACT:R-HSA-556833", "predicate": "biolink:disrupts", "object": "UMLS:C0025245", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00313_MESH_D004827_3"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-556833", "original_object": "UMLS:C0025245"}
{"subject": "UBERON:0001017", "predicate": "biolink:preventative_for_condition", "object": "HP:0033400", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00477_MESH_D017118_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001017", "original_object": "HP:0033400"}
{"subject": "CL:0000037", "predicate": "biolink:treats", "object": "MONDO:0009693", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06809_MESH_D009101_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000037", "original_object": "MESH:D009101"}
{"object": "NCBIGene:1813", "predicate": "biolink:causes", "subject": "GO:0014046", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01100_MESH_D005879_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P14416", "original_subject": "GO:0014046"}
{"object": "NCBIGene:1813", "predicate": "biolink:causes", "subject": "GO:0014046", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01100_MESH_D005879_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "UniProtKB:P14416", "original_subject": "GO:0014046"}
{"subject": "NCBIGene:3558", "predicate": "biolink:produces", "object": "CL:0000084", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11693_MESH_D014605_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P60568", "original_object": "CL:0000084"}
{"subject": "CHEBI:16356", "predicate": "biolink:positively_correlated_with", "object": "GO:0007263", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11792_MESH_D007172_1", "DB00820_MESH_D007172_1", "DB00820_MESH_D011470_1", "DB00820_MESH_D006976_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16356", "original_object": "GO:0007263"}
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{"subject": "REACT:R-HSA-2162123", "predicate": "biolink:has_output", "object": "CHEBI:15627", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00945_MESH_D013927_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-2162123", "original_object": "MESH:D013928"}
{"subject": "CHEBI:81567", "predicate": "biolink:subclass_of", "object": "PR:000000001", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:81567", "original_object": "PR:000000001"}
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{"subject": "UniProtKB:Q72547", "predicate": "biolink:expressed_in", "object": "GO:0039693", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00495_MESH_D015658_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:Q72547", "original_object": "GO:0039693"}
{"subject": "CHEBI:28502", "predicate": "biolink:applied_to_treat", "object": "HP:0100607", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:2695", "original_object": "UMLS:C0013390"}
{"subject": "GO:0001696", "predicate": "biolink:regulates", "object": "HGNC.FAMILY:1927", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06724_MESH_D004415_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0001696", "original_object": "HGNC.FAMILY:1927"}
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{"subject": "UBERON:0004033", "predicate": "biolink:coexists_with", "object": "GO:0098846", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0004033", "original_object": "GO:0098846"}
{"subject": "UNII:4Q52C550XK", "predicate": "biolink:physically_interacts_with", "object": "NCBIGene:931", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00078_MESH_D008224_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C422802", "original_object": "UniProtKB:P11836"}
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{"subject": "CHEBI:18243", "predicate": "biolink:located_in", "object": "UBERON:0035999", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00714_MESH_D010300_1", "DB01200_MESH_D010301_1", "DB00413_MESH_D010300_1", "DB00268_MESH_D010300_1", "DB01200_MESH_D010300_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D004298", "original_object": "UBERON:0035999"}
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{"subject": "GO:0033764", "predicate": "biolink:produces", "object": "CHEBI:16330", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05812_MESH_D011471_6"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0033764", "original_object": "CHEBI:16330"}
{"subject": "CL:0001063", "predicate": "biolink:enables", "object": "GO:0008219", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08870_MESH_D006689_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0001063", "original_object": "GO:0008219"}
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{"subject": "HP:0001945", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "CHEBI:184335", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:6857040"], "tmkp_confidence_score": 0.8347018459598716, "sentences": "Overall, the good stability of DOX-DiR@cerasome (ABC), together with its rapidly accelerated drug release under hyperthermia, made it possible for effective anticancer drug delivery with reduced undesirable premature leakage and on-demand site specific release, thus enhancing chemo-photothermal combination therapy.|NA", "tmkp_ids": ["tmkp:867e621b6100eeb3be07028f3fc18e1bf793b914f4815f7e8ff8900748e1dee7"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "HP:0001945", "original_object": "DRUGBANK:DB15925"}
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{"subject": "NCBIGene:11188", "predicate": "biolink:affects", "object": "UBERON:0000013", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11738_MESH_D006973_1", "DB09242_MESH_D000075222_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "decreased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:Q9Y2I1", "original_object": "UBERON:0000013"}
{"subject": "GO:0005604", "predicate": "biolink:coexists_with", "object": "CL:0000066", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0005769", "original_object": "CL:0000066"}
{"subject": "CHEBI:42820", "predicate": "biolink:disrupts", "object": "HGNC.FAMILY:274", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00536_MESH_D015624_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D019791", "original_object": "HGNC.FAMILY:274"}
{"subject": "NCBIGene:9900", "predicate": "biolink:affects", "object": "GO:0098982", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01202_MESH_D004828_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:Q7L0J3", "original_object": "GO:0098982"}
{"subject": "NCBIGene:9900", "predicate": "biolink:affects", "object": "GO:0098982", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01202_MESH_D004828_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "qualified_predicate": "biolink:causes", "object_direction_qualifier": "increased", "object_aspect_qualifier": "activity", "original_subject": "UniProtKB:Q7L0J3", "original_object": "GO:0098982"}
{"subject": "HP:0005227", "predicate": "biolink:related_to", "object": "MESH:D002895", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "NCIT:C3339", "original_object": "NCIT:C13221"}
{"subject": "UBERON:0001929", "predicate": "biolink:related_to", "object": "CHEBI:60466", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0001929", "original_object": "CHEBI:60466"}
{"subject": "UBERON:0006965", "predicate": "biolink:occurs_in", "object": "GO:0048754", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0006965", "original_object": "GO:0048754"}
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{"subject": "NCBIGene:3630", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0002909", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01067_MESH_D006943_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P01308", "original_object": "MESH:D006943"}
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{"subject": "GO:0006954", "predicate": "biolink:positively_correlated_with", "object": "NCBIGene:3569", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08895_MESH_D001172_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0006954", "original_object": "UniProtKB:P05231"}
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{"subject": "CHEBI:76016", "predicate": "biolink:contraindicated_in", "object": "CHEBI:38623", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:4806", "original_object": "UMLS:C0026457"}
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{"subject": "CL:0000626", "predicate": "biolink:acts_upstream_of", "object": "GO:0007608", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CL:0000626", "original_object": "GO:0007608"}
{"subject": "CHEBI:28790", "predicate": "biolink:preventative_for_condition", "object": "MONDO:0001780", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04884_MESH_D061686_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D012701", "original_object": "MESH:D061686"}
{"subject": "CHEBI:17933", "predicate": "biolink:has_active_ingredient", "object": "CHEBI:17823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11348_MESH_D010024_1", "DB11348_MESH_D006996_1", "DB11348_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002112", "original_object": "MESH:D002117"}
{"subject": "CHEBI:17933", "predicate": "biolink:has_active_ingredient", "object": "CHEBI:17823", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11348_MESH_D010024_1", "DB11348_MESH_D006996_1", "DB11348_MESH_D015663_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D002112", "original_object": "MESH:D002117"}
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{"object": "CHEBI:16359", "predicate": "biolink:produces", "subject": "UBERON:0002423", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB02659_MESH_D001660_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_object": "MESH:D019826", "original_subject": "UBERON:0002423"}
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{"subject": "CHEBI:31184", "predicate": "biolink:negatively_correlated_with", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D009450_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D016410_1", "DB00240_MESH_D003876_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D016460_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C021137", "original_object": "CHEBI:18295"}
{"subject": "CHEBI:31184", "predicate": "biolink:negatively_correlated_with", "object": "CHEBI:18295", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00240_MESH_D009450_1", "DB00240_MESH_D012628_1", "DB00240_MESH_D005076_1", "DB00240_MESH_D016410_1", "DB00240_MESH_D003876_1", "DB00240_MESH_D008179_1", "DB00240_MESH_D011538_1", "DB00240_MESH_D003877_1", "DB00240_MESH_D016460_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C021137", "original_object": "CHEBI:18295"}
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{"subject": "CHEBI:39026", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005098", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00175_MESH_D020521_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D008077", "original_object": "MESH:D020521"}
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{"subject": "CHEBI:26519", "predicate": "biolink:positively_correlated_with", "object": "GO:0036480", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12131_MESH_D003704_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D005609", "original_object": "GO:0036480"}
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{"subject": "NCBIGene:3350", "predicate": "biolink:correlated_with", "object": "CHEBI:28790", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12833_MESH_D002012_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08908", "original_object": "MESH:D012701"}
{"subject": "NCBIGene:3350", "predicate": "biolink:correlated_with", "object": "CHEBI:28790", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12833_MESH_D002012_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P08908", "original_object": "MESH:D012701"}
{"subject": "UNII:Z633861EIM", "predicate": "biolink:similar_to", "object": "NCBIGene:249", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05768_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB05768", "original_object": "UniProtKB:P05186"}
{"subject": "UNII:Z633861EIM", "predicate": "biolink:similar_to", "object": "NCBIGene:249", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB05768_MESH_D007014_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DRUGBANK:DB05768", "original_object": "UniProtKB:P05186"}
{"subject": "GO:0005237", "predicate": "biolink:negatively_correlated_with", "object": "HP:0002360", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00962_MESH_D007319_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0005237", "original_object": "HP:0002360"}
{"subject": "UBERON:0011357", "predicate": "biolink:composed_primarily_of", "object": "PR:000015658", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0011357", "original_object": "PR:000015658"}
{"subject": "HP:0031826", "predicate": "biolink:precedes", "object": "HP:0003394", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00924_MESH_D009128_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0031826", "original_object": "HP:0003394"}
{"subject": "UMLS:C0079189", "predicate": "biolink:ameliorates_condition", "object": "GO:0006954", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB07615_MESH_D065631_2", "DB07615_MESH_D003876_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D016207", "original_object": "GO:0006954"}
{"subject": "CHEBI:26333", "predicate": "biolink:occurs_in", "object": "UBERON:0000955", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08797_MESH_D005334_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D011453", "original_object": "UBERON:0000955"}
{"subject": "UBERON:0010210", "predicate": "biolink:predisposes_to_condition", "object": "HP:0001907", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00266_MESH_D013923_1", "DB00946_MESH_D013923_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0010210", "original_object": "MESH:D013923"}
{"subject": "REACT:R-HSA-390651", "predicate": "biolink:predisposes_to_condition", "object": "MONDO:0005090", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB13676_MESH_D012559_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-390651", "original_object": "MESH:D012559"}
{"subject": "HP:0001257", "predicate": "biolink:negatively_correlated_with", "object": "GO:0022414", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00848_MESH_D001196_1", "DB00848_MESH_D000724_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HP:0001257", "original_object": "GO:0022414"}
{"subject": "CHEBI:16933", "predicate": "biolink:contributes_to", "object": "GO:0009277", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06636_MESH_D009091_1", "DB06636_MESH_D001228_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:16933", "original_object": "GO:0009277"}
{"subject": "CHEBI:17489", "predicate": "biolink:positively_correlated_with", "object": "UBERON:0001796", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00484_MESH_D005902_2", "DB00521_MESH_D009798_1", "DB00521_MESH_D005902_1", "DB00195_MESH_D005902_1", "DB00195_MESH_D009798_1", "DB09351_MESH_D005902_1", "DB09351_MESH_D009798_1", "DB00484_MESH_D009798_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "CHEBI:17489", "original_object": "UBERON:0001796"}
{"subject": "UNII:S866O45PIG", "predicate": "biolink:chemically_similar_to", "object": "UBERON:0008826", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06761_MESH_D012127_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C072197", "original_object": "UBERON:0008826"}
{"subject": "GO:0008213", "predicate": "biolink:disrupts", "object": "UMLS:C1136102", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB03843_MESH_D007251_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008213", "original_object": "UMLS:C1136102"}
{"subject": "GO:0000305", "predicate": "biolink:disrupts", "object": "CHEBI:16991", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB12834_MESH_D016585_1", "DB11989_MESH_D014355_1", "DB00911_MESH_D005873_1", "DB12834_MESH_D005873_1", "DB00911_MESH_D016585_1", "DB00911_MESH_D014245_1", "DB00911_MESH_D008101_1", "DB12834_MESH_D014245_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0000305", "original_object": "MESH:D004247"}
{"subject": "CHEBI:50580", "predicate": "biolink:contraindicated_in", "object": "UMLS:C0030163", "primary_knowledge_source": "infores:drugcentral", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "DrugCentral:237", "original_object": "UMLS:C0030163"}
{"subject": "GO:0007212", "predicate": "biolink:has_participant", "object": "CL:0000700", "primary_knowledge_source": "infores:ubergraph", "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0007212", "original_object": "CL:0000700"}
{"subject": "GO:0008283", "predicate": "biolink:precedes", "object": "CL:0001063", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB04845_MESH_D001943_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "GO:0008283", "original_object": "CL:0001063"}
{"subject": "HGNC.FAMILY:181", "predicate": "biolink:negatively_correlated_with", "object": "HP:0002071", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01186_MESH_D020734_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "HGNC.FAMILY:181", "original_object": "HP:0002071"}
{"subject": "GO:0004714", "predicate": "biolink:regulates", "object": "HP:0031377", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB01254_MESH_D015466_1", "DB01254_MESH_D001752_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "object_direction_qualifier": "upregulates", "original_subject": "GO:0004714", "original_object": "HP:0031377"}
{"subject": "NCBIGene:5468", "predicate": "biolink:directly_physically_interacts_with", "object": "HGNC.FAMILY:2086", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P37231", "original_object": "HGNC.FAMILY:2086"}
{"subject": "NCBIGene:5468", "predicate": "biolink:directly_physically_interacts_with", "object": "HGNC.FAMILY:2086", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00197_MESH_D003924_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UniProtKB:P37231", "original_object": "HGNC.FAMILY:2086"}
{"subject": "UBERON:0025525", "predicate": "biolink:negatively_correlated_with", "object": "HP:0030895", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB08890_MESH_D043183_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "UBERON:0025525", "original_object": "HP:0030895"}
{"subject": "UMLS:C1172636", "predicate": "biolink:disrupts", "object": "CHEBI:8005", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB06219_MESH_D013207_1", "DB06219_MESH_D017192_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:C469289", "original_object": "CHEBI:8005"}
{"subject": "REACT:R-HSA-70171", "predicate": "biolink:occurs_in", "object": "NCBITaxon:5833", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB00468_MESH_D016778_2"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "REACT:R-HSA-70171", "original_object": "NCBITaxon:5833"}
{"subject": "CHEBI:7566", "predicate": "biolink:produces", "object": "CHEBI:26523", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11820_MESH_D014355_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009547", "original_object": "CHEBI:26523"}
{"subject": "CHEBI:7566", "predicate": "biolink:produces", "object": "CHEBI:26523", "primary_knowledge_source": "infores:drugmechdb", "drugmechdb_path_id": ["DB11820_MESH_D014355_1"], "knowledge_level": "knowledge_assertion", "agent_type": "manual_agent", "original_subject": "MESH:D009547", "original_object": "CHEBI:26523"}
{"subject": "MONDO:0004992", "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object": "NCBIGene:213", "primary_knowledge_source": "infores:text-mining-provider-targeted", "publications": ["PMC:5602453", "PMC:9053164"], "tmkp_confidence_score": 0.2376184596187509, "sentences": "Compared to other singular treatment groups, P@-Gem-HSA-NPs (L+) showed a highly synergistic effect in destructing cancer cells by in vitro of combined PDT and chemotherapy (P<0.05).|NA|The greater therapeutic efficiency of CTAC@MSNs-HSA is mainly attributed to the presence of HSA, which increase the cell uptake of nanomaterials and improve their biocompatibility, thus provide the prolonged cytotoxicity of nanomaterials against cancer cells.|NA", "tmkp_ids": ["tmkp:1acfe86ef33199d48c9ac06fad51f1920786bbdfb9cd770915c4e40870282a08", "tmkp:5272965de4ad6fe3443e0d85771f30656c98ea423b21852c97ea5ea3111ee866"], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "original_subject": "MONDO:0004992", "original_object": "DRUGBANK:DB00062"}