{
    "source_type": "primary",
    "edges": [
        {
            "subject_category": "biolink:SmallMolecule",
            "object_category": "biolink:Protein",
            "predicate": "biolink:affects",
            "subject_id": "CHEBI:28748",
            "object_id": "UniProtKB:P18887",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "activity_or_abundance"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:SmallMolecule",
            "object_category": "biolink:Disease",
            "predicate": "biolink:contributes_to",
            "subject_id": "CHEBI:30812",
            "object_id": "MONDO:0005559"
        },
        {
            "subject_category": "biolink:SmallMolecule",
            "object_category": "biolink:Disease",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "UNII:5L3SX16QBQ",
            "object_id": "MONDO:0004979"
        },
        {
            "subject_category": "biolink:SmallMolecule",
            "object_category": "biolink:PhenotypicFeature",
            "predicate": "biolink:contributes_to",
            "subject_id": "CHEBI:37758",
            "object_id": "HP:0001945"
        },
        {
            "subject_category": "biolink:SmallMolecule",
            "object_category": "biolink:PhenotypicFeature",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "CHEBI:9332",
            "object_id": "HP:0000010"
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:Disease",
            "predicate": "biolink:contributes_to",
            "subject_id": "UMLS:C1122087",
            "object_id": "MONDO:0003664"
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:Disease",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "UMLS:C3896731",
            "object_id": "MONDO:0018874"
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:Protein",
            "predicate": "biolink:affects",
            "subject_id": "UniProtKB:P05067",
            "object_id": "UniProtKB:P42261",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "activity_or_abundance"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:PhenotypicFeature",
            "predicate": "biolink:contributes_to",
            "subject_id": "UMLS:C0010592",
            "object_id": "HP:0030953"
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:PhenotypicFeature",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "UMLS:C0010592",
            "object_id": "HP:0030953"
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:ChemicalEntity",
            "predicate": "biolink:affects",
            "subject_id": "UniProtKB:P00533",
            "object_id": "DRUGBANK:DB15037",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "activity_or_abundance"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "decreased"
                }
            ]
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:SmallMolecule",
            "predicate": "biolink:affects",
            "subject_id": "UniProtKB:P01579",
            "object_id": "CHEBI:28544",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "activity_or_abundance"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:Protein",
            "object_category": "biolink:MolecularMixture",
            "predicate": "biolink:affects",
            "subject_id": "UniProtKB:P46013",
            "object_id": "CHEBI:31696",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "activity_or_abundance"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "decreased"
                }
            ]
        },
        {
            "subject_category": "biolink:ChemicalEntity",
            "object_category": "biolink:Disease",
            "predicate": "biolink:contributes_to",
            "subject_id": "CHEBI:50845",
            "object_id": "MONDO:0005560"
        },
        {
            "subject_category": "biolink:ChemicalEntity",
            "object_category": "biolink:Disease",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "DRUGBANK:DB13961",
            "object_id": "MONDO:0011382"
        },
        {
            "subject_category": "biolink:ChemicalEntity",
            "object_category": "biolink:Protein",
            "predicate": "biolink:affects",
            "subject_id": "CHEBI:5186",
            "object_id": "UniProtKB:Q9UNQ0",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "activity_or_abundance"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "decreased"
                }
            ]
        },
        {
            "subject_category": "biolink:ChemicalEntity",
            "object_category": "biolink:PhenotypicFeature",
            "predicate": "biolink:contributes_to",
            "subject_id": "CHEBI:15358",
            "object_id": "HP:0000969"
        },
        {
            "subject_category": "biolink:ChemicalEntity",
            "object_category": "biolink:PhenotypicFeature",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "CHEBI:5537",
            "object_id": "HP:0002018"
        },
        {
            "subject_category": "biolink:MolecularMixture",
            "object_category": "biolink:Protein",
            "predicate": "biolink:affects",
            "subject_id": "CHEBI:6890",
            "object_id": "UniProtKB:Q02156",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "activity_or_abundance"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "decreased"
                }
            ]
        },
        {
            "subject_category": "biolink:MolecularMixture",
            "object_category": "biolink:Disease",
            "predicate": "biolink:contributes_to",
            "subject_id": "CHEBI:59695",
            "object_id": "MONDO:0000437"
        },
        {
            "subject_category": "biolink:MolecularMixture",
            "object_category": "biolink:Disease",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "CHEBI:17833",
            "object_id": "MONDO:0010726"
        },
        {
            "subject_category": "biolink:MolecularMixture",
            "object_category": "biolink:PhenotypicFeature",
            "predicate": "biolink:contributes_to",
            "subject_id": "UNII:781E2AXH0K",
            "object_id": "HP:0003326"
        },
        {
            "subject_category": "biolink:MolecularMixture",
            "object_category": "biolink:PhenotypicFeature",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "UNII:6897GXD6OE",
            "object_id": "HP:0001945"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:SmallMolecule",
            "predicate": "biolink:contributes_to",
            "subject_id": "MONDO:0004992",
            "object_id": "CHEBI:15551"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:SmallMolecule",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "MONDO:0008315",
            "object_id": "CHEBI:4672"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:MolecularMixture",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "MONDO:0004992",
            "object_id": "CHEBI:27899"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:Protein",
            "predicate": "biolink:contributes_to",
            "subject_id": "MONDO:0002771",
            "object_id": "UMLS:C0005740"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:Protein",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "MONDO:0002974",
            "object_id": "UMLS:C4086994"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:ChemicalEntity",
            "predicate": "biolink:contributes_to",
            "subject_id": "MONDO:0007256",
            "object_id": "CHEBI:50845"
        },
        {
            "subject_category": "biolink:Disease",
            "object_category": "biolink:ChemicalEntity",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "MONDO:0005292",
            "object_id": "UNII:O03S90U1F2"
        },
        {
            "subject_category": "biolink:ComplexMolecularMixture",
            "object_category": "biolink:Protein",
            "predicate": "biolink:affects",
            "subject_id": "DRUGBANK:DB15656",
            "object_id": "UniProtKB:O43678",
            "qualifiers": [
                {
                    "qualifier_type_id": "biolink:qualified_predicate",
                    "qualifier_value": "biolink:causes"
                },
                {
                    "qualifier_type_id": "biolink:object_aspect_qualifier",
                    "qualifier_value": "activity_or_abundance"
                },
                {
                    "qualifier_type_id": "biolink:object_direction_qualifier",
                    "qualifier_value": "increased"
                }
            ]
        },
        {
            "subject_category": "biolink:ComplexMolecularMixture",
            "object_category": "biolink:Disease",
            "predicate": "biolink:contributes_to",
            "subject_id": "DRUGBANK:DB15656",
            "object_id": "MONDO:0010528"
        },
        {
            "subject_category": "biolink:ComplexMolecularMixture",
            "object_category": "biolink:Disease",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "DRUGBANK:DB15656",
            "object_id": "MONDO:0005015"
        },
        {
            "subject_category": "biolink:ComplexMolecularMixture",
            "object_category": "biolink:PhenotypicFeature",
            "predicate": "biolink:contributes_to",
            "subject_id": "DRUGBANK:DB15656",
            "object_id": "HP:0030528"
        },
        {
            "subject_category": "biolink:ComplexMolecularMixture",
            "object_category": "biolink:PhenotypicFeature",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "DRUGBANK:DB11003",
            "object_id": "HP:0000969"
        },
        {
            "subject_category": "biolink:PhenotypicFeature",
            "object_category": "biolink:MolecularMixture",
            "predicate": "biolink:contributes_to",
            "subject_id": "HP:0001510",
            "object_id": "CHEBI:27899"
        },
        {
            "subject_category": "biolink:PhenotypicFeature",
            "object_category": "biolink:MolecularMixture",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "HP:0001945",
            "object_id": "CHEBI:27899"
        },
        {
            "subject_category": "biolink:PhenotypicFeature",
            "object_category": "biolink:SmallMolecule",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "HP:0001945",
            "object_id": "CHEBI:28748"
        },
        {
            "subject_category": "biolink:PhenotypicFeature",
            "object_category": "biolink:Protein",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "HP:0001945",
            "object_id": "UniProtKB:P02768"
        },
        {
            "subject_category": "biolink:PhenotypicFeature",
            "object_category": "biolink:ChemicalEntity",
            "predicate": "biolink:treats_or_applied_or_studied_to_treat",
            "subject_id": "HP:0100282",
            "object_id": "UNII:O03S90U1F2"
        }
    ]
}