positive regulation of synaptic vesicle exocytosis


biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

positive regulation of ceramide biosynthetic process


regulation of T-helper 17 type immune response


negative regulation of T-helper 17 type immune response


positive regulation of T-helper 17 type immune response


regulation of T-helper 17 cell differentiation


positive regulation of T-helper 17 cell differentiation


regulation of nuclear receptor-mediated glucocorticoid signaling pathway


regulation of T-helper 17 cell lineage commitment


positive regulation of chemokine (C-X-C motif) ligand 1 production


negative regulation of chemokine (C-X-C motif) ligand 2 production


positive regulation of chemokine (C-X-C motif) ligand 2 production


positive regulation of acrosome reaction


positive regulation of hepatocyte proliferation


negative regulation of endothelial cell apoptotic process


positive regulation of endothelial cell apoptotic process


regulation of ovarian follicle development


regulation of binding of sperm to zona pellucida


regulation of clathrin-dependent endocytosis


positive regulation of clathrin-dependent endocytosis


regulation of reactive oxygen species metabolic process


negative regulation of reactive oxygen species metabolic process


positive regulation of reactive oxygen species metabolic process


positive regulation of neutrophil extravasation


regulation of lamellipodium morphogenesis


positive regulation of lamellipodium morphogenesis


negative regulation of lymphocyte migration


positive regulation of lymphocyte migration


positive regulation of apoptotic cell clearance


positive regulation of protein neddylation


positive regulation of excitatory postsynaptic potential


regulation of glycogen (starch) synthase activity


positive regulation of glycogen (starch) synthase activity


regulation of cAMP-dependent protein kinase activity


negative regulation of cAMP-dependent protein kinase activity


positive regulation of cAMP-dependent protein kinase activity


regulation of hepatic stellate cell activation


regulation of natural killer cell chemotaxis


positive regulation of natural killer cell chemotaxis


positive regulation of blood vessel remodeling


regulation of CD4-positive, alpha-beta T cell activation


negative regulation of CD4-positive, alpha-beta T cell activation


positive regulation of CD4-positive, alpha-beta T cell activation


regulation of entry of bacterium into host cell


positive regulation of T-helper 2 cell cytokine production


negative regulation of CD4-positive, alpha-beta T cell proliferation


positive regulation of CD4-positive, alpha-beta T cell proliferation


positive regulation of DNA biosynthetic process


regulation of platelet-derived growth factor receptor-beta signaling pathway


positive regulation of Arp2/3 complex-mediated actin nucleation


regulation of thyroid hormone generation


regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay


negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay


positive regulation of miRNA catabolic process


positive regulation of miRNA metabolic process


regulation of early endosome to late endosome transport


positive regulation of early endosome to late endosome transport


regulation of receptor catabolic process


positive regulation of receptor catabolic process


negative regulation of stem cell proliferation


positive regulation of stem cell proliferation


positive regulation of sodium ion transmembrane transporter activity


regulation of interleukin-1-mediated signaling pathway


negative regulation of interleukin-1-mediated signaling pathway


negative regulation of dendritic cell apoptotic process


regulation of motor neuron apoptotic process


negative regulation of type B pancreatic cell apoptotic process


regulation of transcription regulatory region DNA binding


negative regulation of transcription regulatory region DNA binding


positive regulation of transcription regulatory region DNA binding


regulation of epithelial cell differentiation involved in kidney development


positive regulation of epithelial cell differentiation involved in kidney development


regulation of cardiac vascular smooth muscle cell differentiation


regulation of cardiac muscle cell differentiation


negative regulation of cardiac muscle cell differentiation


positive regulation of cardiac muscle cell differentiation


negative regulation of stem cell differentiation


positive regulation of stem cell differentiation


regulation of mesenchymal stem cell differentiation


regulation of peptidyl-lysine acetylation


negative regulation of peptidyl-lysine acetylation


positive regulation of peptidyl-lysine acetylation


negative regulation of cytoplasmic translation


positive regulation of cytoplasmic translation


negative regulation of cellular senescence


regulation of double-strand break repair


positive regulation of double-strand break repair


regulation of epithelial cell proliferation involved in lung morphogenesis


regulation of synaptic vesicle clustering


regulation of bicellular tight junction assembly


negative regulation of myoblast proliferation


positive regulation of steroid hormone secretion


positive regulation of corticosteroid hormone secretion


positive regulation of AMPA receptor activity


regulation of pro-B cell differentiation


regulation of forebrain neuron differentiation


regulation of skeletal muscle cell differentiation


negative regulation of skeletal muscle cell differentiation


positive regulation of skeletal muscle cell differentiation


regulation of endothelial cell chemotaxis


negative regulation of endothelial cell chemotaxis


positive regulation of endothelial cell chemotaxis


regulation of double-strand break repair via nonhomologous end joining


negative regulation of double-strand break repair via nonhomologous end joining


positive regulation of double-strand break repair via nonhomologous end joining


regulation of integrin-mediated signaling pathway


positive regulation of integrin-mediated signaling pathway


negative regulation of mesenchymal cell apoptotic process


reactive nitrogen species metabolic process


glycogen binding

biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


positive regulation of endocytic recycling


negative regulation of ATP biosynthetic process


positive regulation of ATP biosynthetic process


regulation of CD8-positive, alpha-beta T cell activation


negative regulation of CD8-positive, alpha-beta T cell activation


positive regulation of CD8-positive, alpha-beta T cell activation


regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell


regulation of dendritic cell differentiation


negative regulation of dendritic cell differentiation


positive regulation of dendritic cell differentiation


negative regulation of osteoclast development


regulation of apoptotic signaling pathway


negative regulation of apoptotic signaling pathway


positive regulation of apoptotic signaling pathway


regulation of extrinsic apoptotic signaling pathway


negative regulation of extrinsic apoptotic signaling pathway


positive regulation of extrinsic apoptotic signaling pathway


regulation of extrinsic apoptotic signaling pathway in absence of ligand


positive regulation of extrinsic apoptotic signaling pathway in absence of ligand


regulation of intrinsic apoptotic signaling pathway


negative regulation of intrinsic apoptotic signaling pathway


positive regulation of intrinsic apoptotic signaling pathway


regulation of phosphatidylcholine biosynthetic process


negative regulation of chromosome organization


positive regulation of chromosome organization


regulation of store-operated calcium entry


negative regulation of cation channel activity


positive regulation of cation channel activity


regulation of unsaturated fatty acid biosynthetic process


positive regulation of unsaturated fatty acid biosynthetic process


regulation of caveolin-mediated endocytosis


Albuminuria

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


diabetic peripheral angiopathy

biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


metabolic dysfunction-associated steatotic liver disease


acquired aneurysmal subarachnoid hemorrhage


Interleukin-6 signaling (Homo sapiens)

biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


Intrinsic Pathway for Apoptosis (Homo sapiens)


Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)


Recognition and association of DNA glycosylase with site containing an affected purine (Homo sapiens)


Displacement of DNA glycosylase by APEX1 (Homo sapiens)


POLB-Dependent Long Patch Base Excision Repair (Homo sapiens)


Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)


Activation of BAD and translocation to mitochondria  (Homo sapiens)


Activation of NOXA and translocation to mitochondria (Homo sapiens)


Release of apoptotic factors from the mitochondria (Homo sapiens)


Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)


Cytochrome c-mediated apoptotic response (Homo sapiens)


Apoptotic cleavage of cellular proteins (Homo sapiens)


SMAC, XIAP-regulated apoptotic response (Homo sapiens)


Apoptotic factor-mediated response (Homo sapiens)


PKA-mediated phosphorylation of CREB (Homo sapiens)


CaMK IV-mediated phosphorylation of CREB (Homo sapiens)


G-protein mediated events (Homo sapiens)


Electric Transmission Across Gap Junctions (Homo sapiens)


Neurotransmitter clearance (Homo sapiens)


Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)


Transmission across Chemical Synapses (Homo sapiens)


Formation of RNA Pol II elongation complex  (Homo sapiens)


RAF-independent MAPK1/3 activation (Homo sapiens)


Formation of the Early Elongation Complex (Homo sapiens)


Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)


E2F-enabled inhibition of pre-replication complex formation (Homo sapiens)


E2F mediated regulation of DNA replication (Homo sapiens)


Activation of BH3-only proteins (Homo sapiens)


Effects of PIP2 hydrolysis (Homo sapiens)


Disinhibition of SNARE formation (Homo sapiens)


GPVI-mediated activation cascade (Homo sapiens)


Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)


Activation of RAS in B cells (Homo sapiens)


Antiviral mechanism by IFN-stimulated genes (Homo sapiens)


Prolactin receptor signaling (Homo sapiens)


ROS and RNS production in phagocytes (Homo sapiens)


Signaling by FGFR in disease (Homo sapiens)


Signaling by ERBB2 in Cancer (Homo sapiens)


Regulation of gene expression by Hypoxia-inducible Factor (Homo sapiens)


Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)


Cross-presentation of particulate exogenous antigens (phagosomes) (Homo sapiens)


Cross-presentation of soluble exogenous antigens (endosomes) (Homo sapiens)


Erythrocytes take up carbon dioxide and release oxygen (Homo sapiens)


Methionine salvage pathway (Homo sapiens)


Erythrocytes take up oxygen and release carbon dioxide (Homo sapiens)


SHC1 events in ERBB2 signaling (Homo sapiens)


PI3K events in ERBB4 signaling (Homo sapiens)


SHC1 events in ERBB4 signaling (Homo sapiens)


Nuclear signaling by ERBB4 (Homo sapiens)


Downregulation of ERBB4 signaling (Homo sapiens)


Cytokine Signaling in Immune system (Homo sapiens)


Spry regulation of FGF signaling (Homo sapiens)


Ca2+ activated K+ channels (Homo sapiens)


Inwardly rectifying K+ channels (Homo sapiens)


Voltage gated Potassium channels (Homo sapiens)


Tandem pore domain potassium channels (Homo sapiens)


Acrosome Reaction and Sperm:Oocyte Membrane Binding (Homo sapiens)


GRB7 events in ERBB2 signaling (Homo sapiens)


Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)


Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)


Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 (Homo sapiens)


Mitochondrial iron-sulfur cluster biogenesis (Homo sapiens)


BMAL1:CLOCK,NPAS2 activates circadian expression (Homo sapiens)


Elevation of cytosolic Ca2+ levels (Homo sapiens)


Activation of PUMA and translocation to mitochondria (Homo sapiens)


Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)


Common Pathway of Fibrin Clot Formation (Homo sapiens)


Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)


Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)


Aerobic respiration and respiratory electron transport (Homo sapiens)


Regulation of KIT signaling (Homo sapiens)


Regulation of signaling by NODAL (Homo sapiens)


Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)


Reversible hydration of carbon dioxide (Homo sapiens)


Synthesis of PIPs at the ER membrane (Homo sapiens)


Phase II - Conjugation of compounds (Homo sapiens)


Fibronectin matrix formation (Homo sapiens)


Polo-like kinase mediated events (Homo sapiens)


Gap junction trafficking and regulation (Homo sapiens)


Metabolism of nucleotides (Homo sapiens)


Transport of the SLBP Dependant Mature mRNA (Homo sapiens)


Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)


Activation of Matrix Metalloproteinases (Homo sapiens)


Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Homo sapiens)


ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)


IRF3 mediated activation of type 1 IFN (Homo sapiens)


Sulfide oxidation to sulfate (Homo sapiens)


Budding and maturation of HIV virion (Homo sapiens)


Early Phase of HIV Life Cycle (Homo sapiens)


Host Interactions of HIV factors (Homo sapiens)


PKA-mediated phosphorylation of key metabolic factors (Homo sapiens)


ChREBP activates metabolic gene expression (Homo sapiens)


PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)


Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)


Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)


Signaling by EGFR in Cancer (Homo sapiens)


PKA activation in glucagon signalling (Homo sapiens)


Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)


Nef mediated downregulation of MHC class I complex cell surface expression (Homo sapiens)


Nef and signal transduction (Homo sapiens)


The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)


Collagen biosynthesis and modifying enzymes (Homo sapiens)


Synthesis of PIPs at the plasma membrane (Homo sapiens)


Synthesis of PIPs at the Golgi membrane (Homo sapiens)


Synthesis of PIPs at the early endosome membrane (Homo sapiens)


Synthesis of PIPs at the late endosome membrane (Homo sapiens)


Sphingolipid de novo biosynthesis (Homo sapiens)


MyD88-independent TLR4 cascade  (Homo sapiens)


mTORC1-mediated signalling (Homo sapiens)


The activation of arylsulfatases (Homo sapiens)


Initial triggering of complement (Homo sapiens)


Terminal pathway of complement (Homo sapiens)


Creation of C4 and C2 activators (Homo sapiens)


HIV Transcription Initiation (Homo sapiens)


HIV Transcription Elongation (Homo sapiens)


Transcription of the HIV genome (Homo sapiens)


Abortive elongation of HIV-1 transcript in the absence of Tat (Homo sapiens)


HIV elongation arrest and recovery (Homo sapiens)


Nef Mediated CD4 Down-regulation (Homo sapiens)


Trafficking and processing of endosomal TLR (Homo sapiens)


Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)


Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)


Export of Viral Ribonucleoproteins from Nucleus (Homo sapiens)


NS1 Mediated Effects on Host Pathways (Homo sapiens)


Viral Messenger RNA Synthesis (Homo sapiens)


Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)


Neurotoxicity of clostridium toxins (Homo sapiens)


Toll-like Receptor Cascades (Homo sapiens)


TICAM1, RIP1-mediated IKK complex recruitment (Homo sapiens)


DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)


Prolonged ERK activation events (Homo sapiens)


Adenylate cyclase activating pathway (Homo sapiens)


Adenylate cyclase inhibitory pathway (Homo sapiens)


Signaling by TGF-beta Receptor Complex (Homo sapiens)


APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)


APC/C-mediated degradation of cell cycle proteins (Homo sapiens)


APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)


Transport and metabolism of PAPS (Homo sapiens)


Glutathione synthesis and recycling (Homo sapiens)


Polymerase switching on the C-strand of the telomere (Homo sapiens)


Processive synthesis on the C-strand of the telomere (Homo sapiens)


Telomere C-strand synthesis initiation (Homo sapiens)


Assembly Of The HIV Virion (Homo sapiens)


Interactions of Vpr with host cellular proteins (Homo sapiens)


Activation of ATR in response to replication stress (Homo sapiens)


Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Homo sapiens)


Phosphorylation of the APC/C (Homo sapiens)


Conjugation of benzoate with glycine (Homo sapiens)


Interactions of Rev with host cellular proteins (Homo sapiens)


Retrograde neurotrophin signalling (Homo sapiens)


Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)


APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)


SHC1 events in EGFR signaling (Homo sapiens)


APOBEC3G mediated resistance to HIV-1 infection (Homo sapiens)


Nuclear import of Rev protein (Homo sapiens)


RIP-mediated NFkB activation via ZBP1 (Homo sapiens)


Serotonin Neurotransmitter Release Cycle (Homo sapiens)


Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)


Acetylcholine binding and downstream events (Homo sapiens)


Nef Mediated CD8 Down-regulation (Homo sapiens)


STING mediated induction of host immune responses (Homo sapiens)


Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)


FGFR1 mutant receptor activation (Homo sapiens)


FGFR2 mutant receptor activation (Homo sapiens)


Synthesis of pyrophosphates in the cytosol (Homo sapiens)


Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)


Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)


Downstream signal transduction (Homo sapiens)


Activation of TRKA receptors (Homo sapiens)


SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)


Signalling to p38 via RIT and RIN (Homo sapiens)


FGFR3 ligand binding and activation (Homo sapiens)


FGFR2 ligand binding and activation (Homo sapiens)


FGFR1 ligand binding and activation (Homo sapiens)


FGFR1b ligand binding and activation (Homo sapiens)


FGFR3b ligand binding and activation (Homo sapiens)


FGFR1c ligand binding and activation (Homo sapiens)


FGFR2c ligand binding and activation (Homo sapiens)


FGFR2b ligand binding and activation (Homo sapiens)


Transport of connexons to the plasma membrane (Homo sapiens)


Pre-NOTCH Processing in the Endoplasmic Reticulum (Homo sapiens)


Pre-NOTCH Processing in Golgi (Homo sapiens)


Pre-NOTCH Expression and Processing (Homo sapiens)


Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)


NRAGE signals death through JNK (Homo sapiens)


p75 NTR receptor-mediated signalling (Homo sapiens)


Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)


Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)


VEGF ligand-receptor interactions (Homo sapiens)


Degradation of beta-catenin by the destruction complex (Homo sapiens)


Metabolism of steroid hormones (Homo sapiens)


Beta-catenin phosphorylation cascade (Homo sapiens)


GRB2 events in ERBB2 signaling (Homo sapiens)


PI3K events in ERBB2 signaling (Homo sapiens)


Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)


Biotin transport and metabolism (Homo sapiens)


Vitamin B2 (riboflavin) metabolism (Homo sapiens)


Metabolism of vitamins and cofactors (Homo sapiens)


Glycosaminoglycan-protein linkage region biosynthesis (Homo sapiens)


AKT phosphorylates targets in the cytosol (Homo sapiens)


AKT phosphorylates targets in the nucleus (Homo sapiens)


Nuclear Events (kinase and transcription factor activation) (Homo sapiens)


Negative regulation of the PI3K/AKT network (Homo sapiens)


ER to Golgi Anterograde Transport (Homo sapiens)


TCF dependent signaling in response to WNT (Homo sapiens)


WNT mediated activation of DVL (Homo sapiens)


Assembly of collagen fibrils and other multimeric structures (Homo sapiens)


Generation of second messenger molecules (Homo sapiens)


Calcineurin activates NFAT (Homo sapiens)


Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)


Role of phospholipids in phagocytosis (Homo sapiens)


YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)


NOSTRIN mediated eNOS trafficking (Homo sapiens)


Linoleic acid (LA) metabolism (Homo sapiens)


Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)


NADE modulates death signalling (Homo sapiens)


NRIF signals cell death from the nucleus (Homo sapiens)


p75NTR recruits signalling complexes (Homo sapiens)


NF-kB is activated and signals survival (Homo sapiens)


Metabolism of amine-derived hormones (Homo sapiens)


Peptide hormone biosynthesis (Homo sapiens)


Glutamate Neurotransmitter Release Cycle (Homo sapiens)


Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (Homo sapiens)


Regulation of gene expression in beta cells (Homo sapiens)


Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells (Homo sapiens)


Regulation of gene expression in early pancreatic precursor cells (Homo sapiens)


Cytochrome P450 - arranged by substrate type (Homo sapiens)


Phase I - Functionalization of compounds (Homo sapiens)


Epigenetic regulation of gene expression (Homo sapiens)


NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)


Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)


PRC2 methylates histones and DNA (Homo sapiens)


Dopamine Neurotransmitter Release Cycle (Homo sapiens)


EGFR interacts with phospholipase C-gamma (Homo sapiens)


Molecules associated with elastic fibres (Homo sapiens)


Synthesis of 5-eicosatetraenoic acids (Homo sapiens)


Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)


Synthesis of 15-eicosatetraenoic acid derivatives (Homo sapiens)


Transcriptional activation of mitochondrial biogenesis (Homo sapiens)


Activation of PPARGC1A (PGC-1alpha) by phosphorylation (Homo sapiens)


Integrin cell surface interactions (Homo sapiens)


Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)


Scavenging of heme from plasma (Homo sapiens)


Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)


TGF-beta receptor signaling activates SMADs (Homo sapiens)


TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)


Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)


Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)


SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)


EGFR Transactivation by Gastrin (Homo sapiens)


The retinoid cycle in cones (daylight vision) (Homo sapiens)


NOTCH2 intracellular domain regulates transcription (Homo sapiens)


Anchoring fibril formation (Homo sapiens)


PI3K/AKT Signaling in Cancer (Homo sapiens)


Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)


Crosslinking of collagen fibrils (Homo sapiens)


Condensation of Prophase Chromosomes (Homo sapiens)


Phosphate bond hydrolysis by NUDT proteins (Homo sapiens)


Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)


Metabolism of ingested SeMet, Sec, MeSec into H2Se (Homo sapiens)


Activation of gene expression by SREBF (SREBP) (Homo sapiens)


SHC-related events triggered by IGF1R (Homo sapiens)


Retinoid cycle disease events (Homo sapiens)


The canonical retinoid cycle in rods (twilight vision) (Homo sapiens)


Fc epsilon receptor (FCERI) signaling (Homo sapiens)


MASTL Facilitates Mitotic Progression (Homo sapiens)


Cohesin Loading onto Chromatin (Homo sapiens)


Activation of the phototransduction cascade (Homo sapiens)


Condensation of Prometaphase Chromosomes (Homo sapiens)


The phototransduction cascade (Homo sapiens)


Interaction With Cumulus Cells And The Zona Pellucida (Homo sapiens)


Mitotic Metaphase and Anaphase (Homo sapiens)


Oxidative Stress Induced Senescence (Homo sapiens)


Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)


Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Homo sapiens)


Oncogene Induced Senescence (Homo sapiens)


DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)


TRIF-mediated programmed cell death (Homo sapiens)


Cytosolic iron-sulfur cluster assembly (Homo sapiens)


Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)


Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)


FBXW7 Mutants and NOTCH1 in Cancer (Homo sapiens)


Acetylcholine Neurotransmitter Release Cycle (Homo sapiens)


Caspase-mediated cleavage of cytoskeletal proteins (Homo sapiens)


Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)


Signaling by NOTCH1 HD Domain Mutants in Cancer (Homo sapiens)


Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)


Ficolins bind to repetitive carbohydrate structures on the target cell surface (Homo sapiens)


FCERI mediated MAPK activation (Homo sapiens)


FCERI mediated Ca+2 mobilization (Homo sapiens)


FCERI mediated NF-kB activation (Homo sapiens)


POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation (Homo sapiens)


POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation (Homo sapiens)


NOTCH2 Activation and Transmission of Signal to the Nucleus (Homo sapiens)


Activation of NIMA Kinases NEK9, NEK6, NEK7 (Homo sapiens)


Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)


Non-integrin membrane-ECM interactions (Homo sapiens)


Scavenging by Class B Receptors (Homo sapiens)


Scavenging by Class A Receptors (Homo sapiens)


Scavenging by Class F Receptors (Homo sapiens)


SUMO is conjugated to E1 (UBA2:SAE1) (Homo sapiens)


SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Homo sapiens)


SUMO is proteolytically processed (Homo sapiens)


SUMOylation of DNA damage response and repair proteins (Homo sapiens)


DEx/H-box helicases activate type I IFN and inflammatory cytokines production  (Homo sapiens)


LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (Homo sapiens)


HDACs deacetylate histones (Homo sapiens)


PKMTs methylate histone lysines (Homo sapiens)


HDMs demethylate histones (Homo sapiens)


RMTs methylate histone arginines (Homo sapiens)


Processing and activation of SUMO (Homo sapiens)


Glycogen storage diseases (Homo sapiens)


SUMOylation of transcription factors (Homo sapiens)


SUMOylation of ubiquitinylation proteins (Homo sapiens)


WNT ligand biogenesis and trafficking (Homo sapiens)


Chromatin modifying enzymes (Homo sapiens)


IRF3-mediated induction of type I IFN (Homo sapiens)


Defects in cobalamin (B12) metabolism (Homo sapiens)


Defects in vitamin and cofactor metabolism (Homo sapiens)


Detoxification of Reactive Oxygen Species (Homo sapiens)


Nuclear Pore Complex (NPC) Disassembly (Homo sapiens)


Loss of Function of SMAD2/3 in Cancer (Homo sapiens)


Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)


Defects in biotin (Btn) metabolism (Homo sapiens)


Regulation of HSF1-mediated heat shock response (Homo sapiens)


HSF1-dependent transactivation (Homo sapiens)


Notch-HLH transcription pathway (Homo sapiens)


Apoptotic cleavage of cell adhesion  proteins (Homo sapiens)


GRB2:SOS provides linkage to MAPK signaling for Integrins  (Homo sapiens)


Diseases associated with glycosaminoglycan metabolism (Homo sapiens)


Defective B4GALT7 causes EDS, progeroid type (Homo sapiens)


Defective CHST3 causes SEDCJD (Homo sapiens)


Defective CHST14 causes EDS, musculocontractural type (Homo sapiens)


Defective CHSY1 causes TPBS (Homo sapiens)


Defective CHST6 causes MCDC1 (Homo sapiens)


Defective EXT2 causes exostoses 2 (Homo sapiens)


Defective ST3GAL3 causes MCT12 and EIEE15 (Homo sapiens)


Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (Homo sapiens)


Transcriptional Regulation by TP53 (Homo sapiens)


p130Cas linkage to MAPK signaling for integrins (Homo sapiens)


Class A/1 (Rhodopsin-like receptors) (Homo sapiens)


Class B/2 (Secretin family receptors) (Homo sapiens)


Nephrin family interactions (Homo sapiens)


NCAM signaling for neurite out-growth (Homo sapiens)


Peptide ligand-binding receptors (Homo sapiens)


Amine ligand-binding receptors (Homo sapiens)


Hormone ligand-binding receptors (Homo sapiens)


Signaling by ROBO receptors (Homo sapiens)


Deactivation of the beta-catenin transactivating complex (Homo sapiens)


Negative regulation of TCF-dependent signaling by WNT ligand antagonists (Homo sapiens)


Diseases associated with N-glycosylation of proteins (Homo sapiens)


Diseases of glycosylation (Homo sapiens)


Myoclonic epilepsy of Lafora (Homo sapiens)


Dopamine clearance from the synaptic cleft (Homo sapiens)


Cytosolic tRNA aminoacylation (Homo sapiens)


Mitochondrial tRNA aminoacylation (Homo sapiens)


Tachykinin receptors bind tachykinins (Homo sapiens)


Chemokine receptors bind chemokines (Homo sapiens)


Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)


Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)


ATF4 activates genes in response to endoplasmic reticulum  stress (Homo sapiens)


ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)


PERK regulates gene expression (Homo sapiens)


IRE1alpha activates chaperones (Homo sapiens)


Unfolded Protein Response (UPR) (Homo sapiens)


ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)


Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)


Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)


Olfactory Signaling Pathway (Homo sapiens)


ABC-family proteins mediated transport (Homo sapiens)


Nuclear Receptor transcription pathway (Homo sapiens)


Beta-catenin independent WNT signaling (Homo sapiens)


Vasopressin-like receptors (Homo sapiens)


Receptor-type tyrosine-protein phosphatases (Homo sapiens)


CD28 dependent PI3K/Akt signaling (Homo sapiens)


CD28 dependent Vav1 pathway (Homo sapiens)


Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)


Alpha-oxidation of phytanate (Homo sapiens)


Beta-oxidation of pristanoyl-CoA (Homo sapiens)


SUMOylation of transcription cofactors (Homo sapiens)


Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding (Homo sapiens)


Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)


Beta-oxidation of very long chain fatty acids (Homo sapiens)


Folding of actin by CCT/TriC (Homo sapiens)


Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)


Muscarinic acetylcholine receptors (Homo sapiens)


Diseases associated with O-glycosylation of proteins (Homo sapiens)


Peroxisomal lipid metabolism (Homo sapiens)


Signal regulatory protein family interactions (Homo sapiens)


Eicosanoid ligand-binding receptors (Homo sapiens)


Prostanoid ligand receptors (Homo sapiens)


Nitric oxide stimulates guanylate cyclase (Homo sapiens)


ADP signalling through P2Y purinoceptor 12 (Homo sapiens)


G beta:gamma signalling through PI3Kgamma (Homo sapiens)


Prostacyclin signalling through prostacyclin receptor (Homo sapiens)


EPHB-mediated forward signaling (Homo sapiens)


EPHA-mediated growth cone collapse (Homo sapiens)


EPH-ephrin mediated repulsion of cells (Homo sapiens)


G-protein beta:gamma signalling (Homo sapiens)


Trafficking of AMPA receptors (Homo sapiens)


Sema3A PAK dependent Axon repulsion (Homo sapiens)


SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)


CRMPs in Sema3A signaling (Homo sapiens)


Regulation of lipid metabolism by PPARalpha (Homo sapiens)


Free fatty acids regulate insulin secretion (Homo sapiens)


Incretin synthesis, secretion, and inactivation (Homo sapiens)


Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)


Sema4D in semaphorin signaling (Homo sapiens)


SUMOylation of SUMOylation proteins (Homo sapiens)


SUMOylation of intracellular receptors (Homo sapiens)


G alpha (q) signalling events (Homo sapiens)


G alpha (12/13) signalling events (Homo sapiens)


Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)


Sema4D induced cell migration and growth-cone collapse (Homo sapiens)


Other semaphorin interactions (Homo sapiens)


Trafficking of GluR2-containing AMPA receptors (Homo sapiens)


Nucleotide-like (purinergic) receptors (Homo sapiens)


Reduction of cytosolic Ca++ levels (Homo sapiens)


Platelet calcium homeostasis (Homo sapiens)


G alpha (s) signalling events (Homo sapiens)


ADP signalling through P2Y purinoceptor 1 (Homo sapiens)


G alpha (i) signalling events (Homo sapiens)


G alpha (z) signalling events (Homo sapiens)


DCC mediated attractive signaling (Homo sapiens)


Netrin mediated repulsion signals (Homo sapiens)


Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)


Role of second messengers in netrin-1 signaling (Homo sapiens)


Lysosphingolipid and LPA receptors (Homo sapiens)


Calcitonin-like ligand receptors (Homo sapiens)


Glucagon-type ligand receptors (Homo sapiens)


Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)


Nectin/Necl  trans heterodimerization (Homo sapiens)


Synthesis, secretion, and deacylation of Ghrelin (Homo sapiens)


Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)


Transport of vitamins, nucleosides, and related molecules (Homo sapiens)


SLC-mediated transmembrane transport (Homo sapiens)


Metal ion SLC transporters (Homo sapiens)


Sodium/Calcium exchangers (Homo sapiens)


Arachidonate production from DAG (Homo sapiens)


Cation-coupled Chloride cotransporters (Homo sapiens)


SIRT1 negatively regulates rRNA expression (Homo sapiens)


ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (Homo sapiens)


Multifunctional anion exchangers (Homo sapiens)


Sodium-coupled phosphate cotransporters (Homo sapiens)


Regulation of commissural axon pathfinding by SLIT and ROBO (Homo sapiens)


Inactivation of CDC42 and RAC1 (Homo sapiens)


Organic anion transporters (Homo sapiens)


Role of ABL in ROBO-SLIT signaling (Homo sapiens)


Thromboxane signalling through TP receptor (Homo sapiens)


mRNA decay by 3' to 5' exoribonuclease (Homo sapiens)


mRNA decay by 5' to 3' exoribonuclease (Homo sapiens)


GP1b-IX-V activation signalling (Homo sapiens)


Passive transport by Aquaporins (Homo sapiens)


Platelet sensitization by LDL (Homo sapiens)


Lysosome Vesicle Biogenesis (Homo sapiens)


Golgi Associated Vesicle Biogenesis (Homo sapiens)


Sodium-coupled sulphate, di- and tri-carboxylate transporters (Homo sapiens)


Proton-coupled monocarboxylate transport (Homo sapiens)


Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Homo sapiens)


Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)


Binding of TCF/LEF:CTNNB1 to target gene promoters (Homo sapiens)


Depolymerization of the Nuclear Lamina (Homo sapiens)


Zinc influx into cells by the SLC39 gene family (Homo sapiens)


Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)


CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)


CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)


CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)


Activation of NMDA receptors and postsynaptic events (Homo sapiens)


Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)


Free fatty acid receptors (Homo sapiens)


Formyl peptide receptors bind formyl peptides and many other ligands (Homo sapiens)


Interaction between L1 and Ankyrins (Homo sapiens)


Signal transduction by L1 (Homo sapiens)


Smooth Muscle Contraction (Homo sapiens)


TAK1-dependent IKK and NF-kappa-B activation   (Homo sapiens)


Asparagine N-linked glycosylation (Homo sapiens)


Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)


Synthesis of substrates in N-glycan biosythesis (Homo sapiens)


Cell-extracellular matrix interactions (Homo sapiens)


Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Homo sapiens)


Interleukin-1 family signaling (Homo sapiens)


Interleukin-12 family signaling (Homo sapiens)


Signaling by Interleukins (Homo sapiens)


Other interleukin signaling (Homo sapiens)


MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)


activated TAK1 mediates p38 MAPK activation (Homo sapiens)


JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1 (Homo sapiens)


Activation of the AP-1 family of transcription factors (Homo sapiens)


Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Homo sapiens)


AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)


Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (Homo sapiens)


HuR (ELAVL1) binds and stabilizes mRNA (Homo sapiens)


Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)


KSRP (KHSRP) binds and destabilizes mRNA (Homo sapiens)


Ionotropic activity of kainate receptors (Homo sapiens)


Activation of kainate receptors upon glutamate binding (Homo sapiens)


Interleukin-2 family signaling (Homo sapiens)


Mitotic G1 phase and G1/S transition (Homo sapiens)


SUMOylation of chromatin organization proteins (Homo sapiens)


Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)


SUMOylation of RNA binding proteins (Homo sapiens)


Asymmetric localization of PCP proteins (Homo sapiens)


SUMOylation of DNA replication proteins (Homo sapiens)


Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)


Regulation of FZD by ubiquitination (Homo sapiens)


Repression of WNT target genes (Homo sapiens)


SUMOylation of DNA methylation proteins (Homo sapiens)


SUMOylation of immune response proteins (Homo sapiens)


Signaling by WNT in cancer (Homo sapiens)


Signaling by CTNNB1 phospho-site mutants (Homo sapiens)


Presynaptic function of Kainate receptors (Homo sapiens)


Defective GALNT3 causes HFTC (Homo sapiens)


Defective LFNG causes SCDO3 (Homo sapiens)


Defective C1GALT1C1 causes TNPS (Homo sapiens)


WNT5A-dependent internalization of FZD4 (Homo sapiens)


Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)


WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Homo sapiens)


PINK1-PRKN Mediated Mitophagy (Homo sapiens)


Uptake and function of anthrax toxins (Homo sapiens)


VEGFR2 mediated vascular permeability (Homo sapiens)


VEGFR2 mediated cell proliferation (Homo sapiens)


Miscellaneous transport and binding events (Homo sapiens)


B-WICH complex positively regulates rRNA expression (Homo sapiens)


Negative epigenetic regulation of rRNA expression (Homo sapiens)


Toxicity of botulinum toxin type D (botD) (Homo sapiens)


Diseases of Immune System (Homo sapiens)


N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)


Uptake and function of diphtheria toxin (Homo sapiens)


Uptake and actions of bacterial toxins (Homo sapiens)


Signaling by LRP5 mutants  (Homo sapiens)


Signaling by RNF43 mutants (Homo sapiens)


Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)


TNFR1-induced NF-kappa-B signaling pathway (Homo sapiens)


Hedgehog ligand biogenesis (Homo sapiens)


Synthesis of diphthamide-EEF2 (Homo sapiens)


Signaling by Retinoic Acid (Homo sapiens)


Release of Hh-Np from the secreting cell (Homo sapiens)


Negative regulation of TCF-dependent signaling by DVL-interacting proteins (Homo sapiens)


Diseases of Mismatch Repair (MMR) (Homo sapiens)


Organic cation/anion/zwitterion transport (Homo sapiens)


Phase 4 - resting membrane potential (Homo sapiens)


Phase 3 - rapid repolarisation (Homo sapiens)


Phase 0 - rapid depolarisation (Homo sapiens)


Phase 1 - inactivation of fast Na+ channels (Homo sapiens)


Metabolic disorders of biological oxidation enzymes (Homo sapiens)


IkBA variant leads to EDA-ID (Homo sapiens)


IRAK4 deficiency (TLR2/4) (Homo sapiens)


Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)


CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)


CLEC7A (Dectin-1) signaling (Homo sapiens)


Diseases associated with glycosylation precursor biosynthesis (Homo sapiens)


Degradation of GLI1 by the proteasome (Homo sapiens)


Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)


ABC transporter disorders (Homo sapiens)


SLC transporter disorders (Homo sapiens)


Disorders of transmembrane transporters (Homo sapiens)


VxPx cargo-targeting to cilium (Homo sapiens)


Cargo trafficking to the periciliary membrane (Homo sapiens)


BBSome-mediated cargo-targeting to cilium (Homo sapiens)


C-type lectin receptors (CLRs) (Homo sapiens)


CD209 (DC-SIGN) signaling (Homo sapiens)


Trafficking of myristoylated proteins to the cilium (Homo sapiens)


RHO GTPases activate PKNs (Homo sapiens)


RHO GTPases activate KTN1 (Homo sapiens)


RHO GTPases activate IQGAPs (Homo sapiens)


RHO GTPases Activate ROCKs (Homo sapiens)


RHO GTPases activate PAKs (Homo sapiens)


TP53 Regulates Metabolic Genes (Homo sapiens)


Ligand-receptor interactions (Homo sapiens)


TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)


GLI proteins bind promoters of Hh responsive genes to promote transcription (Homo sapiens)


Constitutive Signaling by EGFRvIII (Homo sapiens)


APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Homo sapiens)


PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)


Vesicle-mediated transport (Homo sapiens)


Phospholipase C-mediated cascade; FGFR2 (Homo sapiens)


Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)


Downstream signaling of activated FGFR1 (Homo sapiens)


SHC-mediated cascade:FGFR1 (Homo sapiens)


FRS-mediated FGFR1 signaling (Homo sapiens)


Downstream signaling of activated FGFR2 (Homo sapiens)


FRS-mediated FGFR2 signaling (Homo sapiens)


SHC-mediated cascade:FGFR3 (Homo sapiens)


FRS-mediated FGFR3 signaling (Homo sapiens)


Downstream signaling of activated FGFR3 (Homo sapiens)


FRS-mediated FGFR4 signaling (Homo sapiens)


Downstream signaling of activated FGFR4 (Homo sapiens)


SHC-mediated cascade:FGFR4 (Homo sapiens)


Negative regulation of FGFR1 signaling (Homo sapiens)


Negative regulation of FGFR2 signaling (Homo sapiens)


Negative regulation of FGFR3 signaling (Homo sapiens)


Negative regulation of FGFR4 signaling (Homo sapiens)


Signaling by FGFR2 in disease (Homo sapiens)


Signaling by FGFR4 in disease (Homo sapiens)


Signaling by FGFR1 in disease (Homo sapiens)


Translesion synthesis by POLK (Homo sapiens)


Termination of translesion DNA synthesis (Homo sapiens)


Regulation of RAS by GAPs (Homo sapiens)


FGFRL1 modulation of FGFR1 signaling (Homo sapiens)


CLEC7A/inflammasome pathway (Homo sapiens)


Metallothioneins bind metals (Homo sapiens)


Diseases of carbohydrate metabolism (Homo sapiens)


Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)


RHO GTPases Activate WASPs and WAVEs (Homo sapiens)


RHO GTPases Activate Formins (Homo sapiens)


RHO GTPases Activate Rhotekin and Rhophilins (Homo sapiens)


TNFR2 non-canonical NF-kB pathway (Homo sapiens)


RHO GTPases Activate NADPH Oxidases (Homo sapiens)


TNFs bind their physiological receptors (Homo sapiens)


MAP2K and MAPK activation (Homo sapiens)


Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)


Negative feedback regulation of MAPK pathway (Homo sapiens)


Negative regulation of MAPK pathway (Homo sapiens)


TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)


Defective CFTR causes cystic fibrosis (Homo sapiens)


MAPK family signaling cascades (Homo sapiens)


MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)


HDR through Single Strand Annealing (SSA) (Homo sapiens)


HDR through MMEJ (alt-NHEJ) (Homo sapiens)


HDR through Homologous Recombination (HRR) (Homo sapiens)


Regulation of TLR by endogenous ligand (Homo sapiens)


Diseases associated with surfactant metabolism (Homo sapiens)


Defective CSF2RB causes SMDP5 (Homo sapiens)


Ub-specific processing proteases (Homo sapiens)


Ovarian tumor domain proteases (Homo sapiens)


CD22 mediated BCR regulation (Homo sapiens)


Resolution of D-Loop Structures (Homo sapiens)


Sensing of DNA Double Strand Breaks (Homo sapiens)


Homologous DNA Pairing and Strand Exchange (Homo sapiens)


DNA Double Strand Break Response (Homo sapiens)


Processing of DNA double-strand break ends (Homo sapiens)


Cargo concentration in the ER (Homo sapiens)


Formation of Incision Complex in GG-NER (Homo sapiens)


Nucleotide Excision Repair (Homo sapiens)


Post-translational protein modification (Homo sapiens)


Respiratory electron transport (Homo sapiens)


Presynaptic nicotinic acetylcholine receptors (Homo sapiens)


Highly sodium permeable postsynaptic acetylcholine nicotinic receptors (Homo sapiens)


Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)


Highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)


Formation of TC-NER Pre-Incision Complex (Homo sapiens)


Synthesis of wybutosine at G37 of tRNA(Phe) (Homo sapiens)


Interleukin-6 family signaling (Homo sapiens)


tRNA processing in the nucleus (Homo sapiens)


Interleukin-4 and Interleukin-13 signaling (Homo sapiens)


IL-6-type cytokine receptor ligand interactions (Homo sapiens)


rRNA modification in the nucleus and cytosol (Homo sapiens)


TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)


rRNA modification in the mitochondrion (Homo sapiens)


Neurexins and neuroligins (Homo sapiens)


Protein-protein interactions at synapses (Homo sapiens)


TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)


Metal sequestration by antimicrobial proteins (Homo sapiens)


Signaling by moderate kinase activity BRAF mutants (Homo sapiens)


Signaling by BRAF and RAF1 fusions (Homo sapiens)


RAS signaling downstream of NF1 loss-of-function variants (Homo sapiens)


TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)


TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)


TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)


TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)


FGFR2 alternative splicing (Homo sapiens)


TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)


TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)


TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)


Regulation of TP53 Activity through Phosphorylation (Homo sapiens)


Regulation of TP53 Activity through Acetylation (Homo sapiens)


Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)


Regulation of TP53 Activity through Methylation (Homo sapiens)


Regulation of TP53 Expression and Degradation (Homo sapiens)


Negative regulation of MET activity (Homo sapiens)


COPI-mediated anterograde transport (Homo sapiens)


COPI-independent Golgi-to-ER retrograde traffic (Homo sapiens)


Retrograde transport at the Trans-Golgi-Network (Homo sapiens)


Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)


PI5P Regulates TP53 Acetylation (Homo sapiens)


Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)


Assembly of the ORC complex at the origin of replication (Homo sapiens)


CDC6 association with the ORC:origin complex (Homo sapiens)


Orc1 removal from chromatin (Homo sapiens)


DNA replication initiation (Homo sapiens)


Activation of the pre-replicative complex (Homo sapiens)


DNA Replication Pre-Initiation (Homo sapiens)


Switching of origins to a post-replicative state (Homo sapiens)


Processive synthesis on the lagging strand (Homo sapiens)


G1/S-Specific Transcription (Homo sapiens)


Cyclin D associated events in G1 (Homo sapiens)


Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)


G2/M DNA damage checkpoint (Homo sapiens)


G2/M DNA replication checkpoint (Homo sapiens)


G1/S DNA Damage Checkpoints (Homo sapiens)


Mitotic Spindle Checkpoint (Homo sapiens)


Glycogen breakdown (glycogenolysis) (Homo sapiens)


Metabolism of amino acids and derivatives (Homo sapiens)


Pentose phosphate pathway (Homo sapiens)


Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)


Citric acid cycle (TCA cycle) (Homo sapiens)


mRNA Splicing - Minor Pathway (Homo sapiens)


Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)


Transport of nucleotide sugars (Homo sapiens)


RNA Polymerase I Transcription Initiation (Homo sapiens)


RNA Polymerase I Promoter Escape (Homo sapiens)


Insulin receptor signalling cascade (Homo sapiens)


Signaling by Insulin receptor (Homo sapiens)


Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Homo sapiens)


Processing of Capped Intronless Pre-mRNA (Homo sapiens)


Triglyceride biosynthesis (Homo sapiens)


Dissolution of Fibrin Clot (Homo sapiens)


Platelet Adhesion to exposed collagen (Homo sapiens)


Platelet activation, signaling and aggregation (Homo sapiens)


Response to elevated platelet cytosolic Ca2+ (Homo sapiens)


Platelet Aggregation (Plug Formation) (Homo sapiens)


RNA Polymerase III Transcription Initiation From Type 1 Promoter (Homo sapiens)


RNA Polymerase III Transcription Initiation From Type 3 Promoter (Homo sapiens)


mitochondrial fatty acid beta-oxidation of saturated fatty acids (Homo sapiens)


mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (Homo sapiens)


Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (Homo sapiens)


Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (Homo sapiens)


Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Homo sapiens)


Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Homo sapiens)


Beta oxidation of butanoyl-CoA to acetyl-CoA (Homo sapiens)


Processing of Intronless Pre-mRNAs (Homo sapiens)


Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Homo sapiens)


Interferon gamma signaling (Homo sapiens)


Advanced glycosylation endproduct receptor signaling (Homo sapiens)


Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)


ERBB2 Activates PTK6 Signaling (Homo sapiens)


Wax and plasmalogen biosynthesis (Homo sapiens)


PTK6 Regulates Proteins Involved in RNA Processing (Homo sapiens)


PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)


Synaptic adhesion-like molecules (Homo sapiens)


Phosphate bond hydrolysis by NTPDase proteins (Homo sapiens)


Butyrophilin (BTN) family interactions (Homo sapiens)


Signaling by FGFR2 IIIa TM (Homo sapiens)


MET activates RAS signaling (Homo sapiens)


MET activates PI3K/AKT signaling (Homo sapiens)


Signaling by FGFR3 fusions in cancer (Homo sapiens)


Transcriptional Regulation by VENTX (Homo sapiens)


Interleukin-20 family signaling (Homo sapiens)


Golgi-to-ER retrograde transport (Homo sapiens)


Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)


Clathrin-mediated endocytosis (Homo sapiens)


PTK6 promotes HIF1A stabilization (Homo sapiens)


Downregulation of ERBB2 signaling (Homo sapiens)


Reelin signalling pathway (Homo sapiens)


Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)


E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)


Negative regulation of activity of TFAP2 (AP-2) family transcription factors (Homo sapiens)


Activation of the TFAP2 (AP-2) family of transcription factors (Homo sapiens)


TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)


TFAP2 (AP-2) family regulates transcription of cell cycle factors (Homo sapiens)


rRNA processing in the mitochondrion (Homo sapiens)


TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation (Homo sapiens)


MET activates PTK2 signaling (Homo sapiens)


CREB3 factors activate genes (Homo sapiens)


InlB-mediated entry of Listeria monocytogenes into host cell (Homo sapiens)


MET interacts with TNS proteins (Homo sapiens)


MET activates RAP1 and RAC1 (Homo sapiens)


MET promotes cell motility (Homo sapiens)


RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)


Listeria monocytogenes entry into host cells (Homo sapiens)


InlA-mediated entry of Listeria monocytogenes into host cells (Homo sapiens)


Transcriptional regulation by RUNX3 (Homo sapiens)


Transcriptional regulation by RUNX2 (Homo sapiens)


Transcriptional regulation by RUNX1 (Homo sapiens)


GABA synthesis, release, reuptake and degradation (Homo sapiens)


Regulation of RUNX1 Expression and Activity (Homo sapiens)


Receptor Mediated Mitophagy (Homo sapiens)


Aryl hydrocarbon receptor signalling (Homo sapiens)


RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)


Regulation of RUNX2 expression and activity (Homo sapiens)


RUNX2 regulates osteoblast differentiation (Homo sapiens)


RUNX2 regulates chondrocyte maturation (Homo sapiens)


RUNX2 regulates bone development (Homo sapiens)


RUNX2 regulates genes involved in cell migration (Homo sapiens)


RUNX3 regulates CDKN1A transcription (Homo sapiens)


RUNX3 regulates NOTCH signaling (Homo sapiens)


Regulation of RUNX3 expression and activity (Homo sapiens)


Regulation of PTEN mRNA translation (Homo sapiens)


Regulation of PTEN gene transcription (Homo sapiens)


Collagen chain trimerization (Homo sapiens)


Competing endogenous RNAs (ceRNAs) regulate PTEN translation (Homo sapiens)


Regulation of PTEN localization (Homo sapiens)


Regulation of PTEN stability and activity (Homo sapiens)


RUNX3 Regulates Immune Response and Cell Migration (Homo sapiens)


Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)


RUNX3 regulates WNT signaling (Homo sapiens)


RUNX3 regulates YAP1-mediated transcription (Homo sapiens)


RUNX3 regulates BCL2L11 (BIM) transcription (Homo sapiens)


Carboxyterminal post-translational modifications of tubulin (Homo sapiens)


Assembly of active LPL and LIPC lipase complexes (Homo sapiens)


G beta:gamma signalling through CDC42 (Homo sapiens)


Interleukin-35 Signalling (Homo sapiens)


Transcriptional Regulation by MECP2 (Homo sapiens)


Loss of function of MECP2 in Rett syndrome (Homo sapiens)


Signaling by NTRK2 (TRKB) (Homo sapiens)


Signaling by Erythropoietin (Homo sapiens)


Intracellular signaling by second messengers (Homo sapiens)


Signaling by Nuclear Receptors (Homo sapiens)


Signaling by Receptor Tyrosine Kinases (Homo sapiens)


Signaling by TGFB family members (Homo sapiens)


Rab regulation of trafficking (Homo sapiens)


Extra-nuclear estrogen signaling (Homo sapiens)


Calnexin/calreticulin cycle (Homo sapiens)


Regulation of expression of SLITs and ROBOs (Homo sapiens)


ROBO receptors bind AKAP5 (Homo sapiens)


NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)


NOTCH4 Intracellular Domain Regulates Transcription (Homo sapiens)


NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)


TLR3-mediated TICAM1-dependent programmed cell death (Homo sapiens)


TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)


TICAM1,TRAF6-dependent induction of TAK1 complex (Homo sapiens)


Noncanonical activation of NOTCH3 (Homo sapiens)


Estrogen-dependent gene expression (Homo sapiens)


Biosynthesis of EPA-derived SPMs (Homo sapiens)


Loss of MECP2 binding ability to the NCoR/SMRT complex (Homo sapiens)


Regulation of MECP2 expression and activity (Homo sapiens)


MECP2 regulates neuronal receptors and channels (Homo sapiens)


MECP2 regulates transcription of neuronal ligands (Homo sapiens)


MECP2 regulates transcription factors (Homo sapiens)


NR1H2 and NR1H3-mediated signaling (Homo sapiens)


Activated NTRK2 signals through RAS (Homo sapiens)


Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)


Erythropoietin activates Phospholipase C gamma (PLCG) (Homo sapiens)


Erythropoietin activates RAS (Homo sapiens)


Biosynthesis of maresin-like SPMs (Homo sapiens)


Activated NTRK2 signals through PI3K (Homo sapiens)


Activated NTRK2 signals through FRS2 and FRS3 (Homo sapiens)


NR1H2 & NR1H3 regulate gene expression linked to lipogenesis (Homo sapiens)


NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Homo sapiens)


NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake  (Homo sapiens)


NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose (Homo sapiens)


NGF-stimulated transcription (Homo sapiens)


Activated NTRK2 signals through FYN (Homo sapiens)


Activated NTRK2 signals through CDK5 (Homo sapiens)


Peroxisomal protein import (Homo sapiens)


Signaling by NTRK3 (TRKC) (Homo sapiens)


Activated NTRK3 signals through RAS (Homo sapiens)


Interferon alpha/beta signaling (Homo sapiens)


Interleukin receptor SHC signaling (Homo sapiens)


Regulation of signaling by CBL (Homo sapiens)


TRAF3-dependent IRF activation pathway (Homo sapiens)


Nonsense-Mediated Decay (NMD) (Homo sapiens)


TRAF6 mediated IRF7 activation (Homo sapiens)


TRAF6 mediated NF-kB activation (Homo sapiens)


NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)


Ion transport by P-type ATPases (Homo sapiens)


Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)


IKK complex recruitment mediated by RIP1 (Homo sapiens)


IRAK2 mediated activation of TAK1 complex (Homo sapiens)


TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)


Molybdenum cofactor biosynthesis (Homo sapiens)


Transport to the Golgi and subsequent modification (Homo sapiens)


Activated NTRK3 signals through PI3K (Homo sapiens)


Diseases of Base Excision Repair (Homo sapiens)


Assembly and cell surface presentation of NMDA receptors (Homo sapiens)


Chaperone Mediated Autophagy (Homo sapiens)


FOXO-mediated transcription (Homo sapiens)


Regulation of localization of FOXO transcription factors (Homo sapiens)


FOXO-mediated transcription of cell death genes (Homo sapiens)


FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)


Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)


Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)


Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)


FOXO-mediated transcription of cell cycle genes (Homo sapiens)


Activation of RAC1 downstream of NMDARs (Homo sapiens)


Activation of AMPK downstream of NMDARs (Homo sapiens)


EGR2 and SOX10-mediated initiation of Schwann cell myelination (Homo sapiens)


NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis (Homo sapiens)


NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis  (Homo sapiens)


Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)


Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)


Estrogen-stimulated signaling through PRKCZ (Homo sapiens)


Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Homo sapiens)


Infection with Mycobacterium tuberculosis (Homo sapiens)


Prevention of phagosomal-lysosomal fusion (Homo sapiens)


Modulation by Mtb of host immune system (Homo sapiens)


Response of Mtb to phagocytosis (Homo sapiens)


Amino acids regulate mTORC1 (Homo sapiens)


Alpha-protein kinase 1 signaling pathway (Homo sapiens)


Diseases of programmed cell death (Homo sapiens)


N-glycan trimming and elongation in the cis-Golgi (Homo sapiens)


Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)


Signaling by MAPK mutants (Homo sapiens)


Sensory processing of sound (Homo sapiens)


Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)


Signaling by MRAS-complex mutants (Homo sapiens)


ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)


Purinergic signaling in leishmaniasis infection (Homo sapiens)


Defective factor VIII causes hemophilia A (Homo sapiens)


Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)


CD163 mediating an anti-inflammatory response (Homo sapiens)


FCGR3A-mediated IL10 synthesis (Homo sapiens)


LTC4-CYSLTR mediated IL4 production (Homo sapiens)


Signaling by ERBB2 ECD mutants (Homo sapiens)


Acetylcholine inhibits contraction of outer hair cells (Homo sapiens)


Defective factor IX causes hemophilia B (Homo sapiens)


Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)


Signaling by KIT in disease (Homo sapiens)


Signaling by PDGFR in disease (Homo sapiens)


Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)


Signaling by membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)


Signaling by CSF3 (G-CSF) (Homo sapiens)


Diseases of mitotic cell cycle (Homo sapiens)


Potential therapeutics for SARS (Homo sapiens)


Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)


FLT3 signaling in disease (Homo sapiens)


Maturation of nucleoprotein (Homo sapiens)


Maturation of spike protein (Homo sapiens)


Translation of Structural Proteins (Homo sapiens)


Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)


Defective RIPK1-mediated regulated necrosis (Homo sapiens)


Signaling by ALK in cancer (Homo sapiens)


STAT3 nuclear events downstream of ALK signaling (Homo sapiens)


STAT5 activation downstream of FLT3 ITD mutants (Homo sapiens)


Signaling by FLT3 fusion proteins (Homo sapiens)


Signaling by FLT3 ITD and TKD mutants (Homo sapiens)


Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)


Negative regulation of FLT3 (Homo sapiens)


FLT3 signaling through SRC family kinases (Homo sapiens)


FLT3 signaling by CBL mutants (Homo sapiens)


Regulation of HMOX1 expression and activity (Homo sapiens)


Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)


Sensory perception of taste (Homo sapiens)


Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)


Sensory perception of salty taste (Homo sapiens)


Defective Intrinsic Pathway for Apoptosis (Homo sapiens)


TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)


N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)


N-Glycan antennae elongation (Homo sapiens)


Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)


Termination of O-glycan biosynthesis (Homo sapiens)


GABA B receptor activation (Homo sapiens)


Growth hormone receptor signaling (Homo sapiens)


Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)


Factors involved in megakaryocyte development and platelet production (Homo sapiens)


Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)


Signaling by the B Cell Receptor (BCR) (Homo sapiens)


Total Hip Replacement

biolink:Procedure biolink:ActivityAndBehavior biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


Pulse Rate

biolink:ClinicalAttribute biolink:Attribute biolink:OntologyClass biolink:NamedThing


Right ventricular ejection fraction (observable entity)


Nucleated red blood cell count procedure


Non-high density lipoprotein cholesterol (substance)


Eosinophil percent differential count (procedure)


Monocyte percent differential count (procedure)


Subcutaneous Fat, Abdominal

biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


Dementia associated with Parkinson's Disease


Microalbuminuria due to type 2 diabetes mellitus