negative regulation of vasculature development


response to ketone

biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


positive regulation of transcription of nucleolar large rRNA by RNA polymerase I


negative regulation of delayed rectifier potassium channel activity


positive regulation of proteolysis involved in protein catabolic process


positive regulation of extracellular matrix organization


regulation of protein modification by small protein conjugation or removal


positive regulation of sprouting angiogenesis


regulation of wound healing, spreading of epidermal cells


regulation of IRE1-mediated unfolded protein response


regulation of collagen fibril organization


positive regulation of gastro-intestinal system smooth muscle contraction


positive regulation of ubiquitin protein ligase activity


negative regulation of cardiocyte differentiation


positive regulation of morphogenesis of an epithelium


regulation of Fc-gamma receptor signaling pathway involved in phagocytosis


regulation of animal organ morphogenesis


regulation of ubiquitin-dependent protein catabolic process


regulation of neural precursor cell proliferation


positive regulation of steroid hormone secretion


positive regulation of corticosteroid hormone secretion


positive regulation of endothelial cell chemotaxis


anterograde neuronal dense core vesicle transport


negative regulation of canonical Wnt signaling pathway


negative regulation of hormone biosynthetic process


positive regulation of cell-substrate junction organization


positive regulation of hair follicle development


positive regulation of mitotic cell cycle phase transition


positive regulation of proteasomal ubiquitin-dependent protein catabolic process


positive regulation of protein kinase activity


regulation of branching involved in ureteric bud morphogenesis


regulation of calcium ion export across plasma membrane


regulation of canonical Wnt signaling pathway


regulation of gene silencing by regulatory ncRNA


regulation of mitotic cell cycle phase transition


regulation of retrograde transport, endosome to Golgi


beta-catenin-TCF complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


postsynaptic density, intracellular component


postsynaptic specialization, intracellular component


RNA polymerase II transcription repressor complex


activin receptor binding

biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


calcium-dependent protein serine/threonine phosphatase activity


G protein-coupled receptor kinase activity


inward rectifier potassium channel activity


protein serine/threonine kinase activator activity


receptor serine/threonine kinase binding


RNA polymerase II core promoter sequence-specific DNA binding


transcription regulator inhibitor activity


transforming growth factor beta receptor binding


type II transforming growth factor beta receptor binding


vascular endothelial growth factor receptor 2 binding


vascular endothelial growth factor receptor binding


Abacavir ADME (Homo sapiens)

biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)


Activated NTRK2 signals through PI3K (Homo sapiens)


Activation of BH3-only proteins (Homo sapiens)


Chromatin modifying enzymes (Homo sapiens)


Defective ST3GAL3 causes MCT12 and EIEE15 (Homo sapiens)


DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)


antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent


Epigenetic regulation of gene expression (Homo sapiens)


ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (Homo sapiens)


FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)


G1/S DNA Damage Checkpoints (Homo sapiens)


Interleukin-1 family signaling (Homo sapiens)


Intrinsic Pathway for Apoptosis (Homo sapiens)


keratan sulfate proteoglycan catabolic process


MAP2K and MAPK activation (Homo sapiens)


Mitotic G1 phase and G1/S transition (Homo sapiens)


NGF-stimulated transcription (Homo sapiens)


Nuclear Events (kinase and transcription factor activation) (Homo sapiens)


Oxidative Stress Induced Senescence (Homo sapiens)


Phase 3 - rapid repolarisation (Homo sapiens)


Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)


Prolonged ERK activation events (Homo sapiens)


Regulation of RUNX2 expression and activity (Homo sapiens)


Repression of WNT target genes (Homo sapiens)


RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)


RUNX2 regulates chondrocyte maturation (Homo sapiens)


Signaling by moderate kinase activity BRAF mutants (Homo sapiens)


Signaling by PDGFR in disease (Homo sapiens)


Signaling by Receptor Tyrosine Kinases (Homo sapiens)


SUMOylation of DNA methylation proteins (Homo sapiens)


Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)


Synthesis of PIPs at the plasma membrane (Homo sapiens)


Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)


TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)


negative regulation of G0 to G1 transition


Transcriptional regulation by RUNX1 (Homo sapiens)


Transcriptional regulation by RUNX3 (Homo sapiens)


Uptake and actions of bacterial toxins (Homo sapiens)


Uptake and function of anthrax toxins (Homo sapiens)


lymphocyte activation involved in immune response


respiratory burst involved in inflammatory response


negative regulation of immunoglobulin production


respiratory burst involved in defense response


positive regulation of response to biotic stimulus


regulation of myeloid leukocyte mediated immunity


inner mitochondrial membrane organization


nucleoside monophosphate biosynthetic process


purine nucleoside monophosphate biosynthetic process


nucleoside diphosphate metabolic process


ribonucleoside monophosphate biosynthetic process


pyrimidine ribonucleoside triphosphate biosynthetic process


pyrimidine ribonucleotide biosynthetic process


regulation of phosphatidylinositol biosynthetic process


regulation of D-glucose transmembrane transport


positive regulation of D-glucose transmembrane transport


L-methionine salvage from methylthioadenosine


microtubule polymerization or depolymerization


positive regulation of nuclease activity


regulation of establishment or maintenance of cell polarity


positive regulation of T cell differentiation in thymus


circadian sleep/wake cycle, non-REM sleep


negative regulation of isotype switching


positive regulation of muscle contraction


positive regulation of smooth muscle contraction


regulation of synapse structure or activity


regulation of acyl-CoA biosynthetic process


negative regulation of lipoprotein lipase activity


positive regulation of smooth muscle cell differentiation


medium-chain fatty acid catabolic process


negative regulation of respiratory burst involved in inflammatory response


negative regulation of ryanodine-sensitive calcium-release channel activity


cell-cell adhesion involved in gastrulation


positive regulation of monocyte chemotactic protein-1 production


positive regulation of chemokine (C-C motif) ligand 5 production


chemokine (C-X-C motif) ligand 2 production


carbohydrate derivative catabolic process


regulation of store-operated calcium channel activity


positive regulation of cell proliferation involved in kidney development


positive regulation of cellular respiration


negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress


regulation of non-motile cilium assembly


negative regulation of epithelial cell apoptotic process


regulation of cAMP-dependent protein kinase activity


negative regulation of intrinsic apoptotic signaling pathway


adrenomedullin receptor signaling pathway


negative regulation of protein secretion


protein localization to site of double-strand break


regulation of 3'-UTR-mediated mRNA stabilization


regulation of apoptotic process in bone marrow cell


regulation of circadian sleep/wake cycle, non-REM sleep


ribonucleoside monophosphate metabolic process


calcium- and calmodulin-dependent protein kinase complex


corticotropin-releasing hormone receptor binding


phosphate transmembrane transporter activity


intronic transcription regulatory region sequence-specific DNA binding


ligand-gated monoatomic anion channel activity


phosphotransferase activity, nitrogenous group as acceptor


protein phosphorylated amino acid binding


transferase activity, transferring alkyl or aryl (other than methyl) groups


Activation of NMDA receptors and postsynaptic events (Homo sapiens)


Activation of PPARGC1A (PGC-1alpha) by phosphorylation (Homo sapiens)


Activation of RAC1 downstream of NMDARs (Homo sapiens)


Advanced glycosylation endproduct receptor signaling (Homo sapiens)


Common Pathway of Fibrin Clot Formation (Homo sapiens)


Downstream signal transduction (Homo sapiens)


Metabolism of nucleotides (Homo sapiens)


Negative regulation of FGFR4 signaling (Homo sapiens)


Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)


Peroxisomal protein import (Homo sapiens)


Polo-like kinase mediated events (Homo sapiens)


PTK6 Regulates Proteins Involved in RNA Processing (Homo sapiens)


Regulation of MECP2 expression and activity (Homo sapiens)


Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)


Signaling by NTRK2 (TRKB) (Homo sapiens)


SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)


Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)


TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)


negative regulation of organelle organization


positive regulation of triglyceride storage


negative regulation of granulocyte differentiation


regulation of mammary gland epithelial cell proliferation


intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator


positive regulation of MHC class I biosynthetic process


vesicle targeting, to, from or within Golgi


embryonic retina morphogenesis in camera-type eye


negative regulation of digestive system process


positive regulation of protein tyrosine kinase activity


regulation of Wnt signaling pathway, planar cell polarity pathway


negative regulation of endothelial cell apoptotic process


regulation of receptor catabolic process


positive regulation of receptor catabolic process


chorionic trophoblast cell proliferation


membrane fusion involved in viral entry into host cell


pyrimidine ribonucleoside monophosphate metabolic process


ATPase dependent transmembrane transport complex


extrinsic component of external side of plasma membrane


low-density lipoprotein particle receptor activity


organic cation transmembrane transporter activity


pyrimidine nucleoside transmembrane transporter activity


RNA polymerase II CTD heptapeptide repeat phosphatase activity


ABC-family proteins mediated transport (Homo sapiens)


ABC transporter disorders (Homo sapiens)


Antiviral mechanism by IFN-stimulated genes (Homo sapiens)


Assembly of the ORC complex at the origin of replication (Homo sapiens)


Disorders of transmembrane transporters (Homo sapiens)


Downregulation of ERBB2 signaling (Homo sapiens)


EGR2 and SOX10-mediated initiation of Schwann cell myelination (Homo sapiens)


FGFR2 alternative splicing (Homo sapiens)


Maturation of nucleoprotein (Homo sapiens)


Metallothioneins bind metals (Homo sapiens)


NS1 Mediated Effects on Host Pathways (Homo sapiens)


Nuclear signaling by ERBB4 (Homo sapiens)


Other interleukin signaling (Homo sapiens)


Phase II - Conjugation of compounds (Homo sapiens)


Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)


Regulation of signaling by NODAL (Homo sapiens)


RMTs methylate histone arginines (Homo sapiens)


Scavenging by Class F Receptors (Homo sapiens)


Signaling by ERBB2 in Cancer (Homo sapiens)


homologous chromosome pairing at meiosis


regulation of hydrogen peroxide metabolic process


regulation of signaling receptor activity


regulation of hydrogen peroxide biosynthetic process


multicellular organismal response to stress


positive regulation of nucleocytoplasmic transport


negative regulation of mRNA splicing, via spliceosome


regulation of transmission of nerve impulse


dichotomous subdivision of terminal units involved in salivary gland branching


skeletal muscle acetylcholine-gated channel clustering


metanephric glomerular mesangium development


regulation of postsynaptic specialization assembly


negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway


positive regulation of dendrite development


negative regulation of long-term synaptic potentiation


positive regulation of extracellular matrix assembly


regulation of relaxation of cardiac muscle


negative regulation of autophagy of mitochondrion


regulation of modification of synaptic structure


positive regulation of protein localization to cell surface


positive regulation of basement membrane assembly involved in embryonic body morphogenesis


positive regulation of neuron projection arborization


regulation of glutamate receptor clustering


vascular endothelial growth factor receptor-2 signaling pathway


box C/D methylation guide snoRNP complex


eukaryotic translation initiation factor 2 complex


proteasome regulatory particle, base subcomplex


fructose transmembrane transporter activity


diacylglycerol-dependent serine/threonine kinase activity


secondary active sulfate transmembrane transporter activity


Acrosome Reaction and Sperm:Oocyte Membrane Binding (Homo sapiens)


APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)


Asymmetric localization of PCP proteins (Homo sapiens)


Conjugation of benzoate with glycine (Homo sapiens)


Cross-presentation of soluble exogenous antigens (endosomes) (Homo sapiens)


Defective CFTR causes cystic fibrosis (Homo sapiens)


Defects in cobalamin (B12) metabolism (Homo sapiens)


Degradation of GLI1 by the proteasome (Homo sapiens)


FCERI mediated NF-kB activation (Homo sapiens)


Hedgehog ligand biogenesis (Homo sapiens)


Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)


MECP2 regulates transcription of neuronal ligands (Homo sapiens)


Peptide hormone biosynthesis (Homo sapiens)


PKA activation in glucagon signalling (Homo sapiens)


PKA-mediated phosphorylation of CREB (Homo sapiens)


Regulation of HMOX1 expression and activity (Homo sapiens)


Regulation of PTEN stability and activity (Homo sapiens)


Regulation of RUNX3 expression and activity (Homo sapiens)


SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)


Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)


TLR3-mediated TICAM1-dependent programmed cell death (Homo sapiens)


Trafficking of AMPA receptors (Homo sapiens)


TRIF-mediated programmed cell death (Homo sapiens)


positive regulation of cellular extravasation


renal system process involved in regulation of systemic arterial blood pressure


activation of transmembrane receptor protein tyrosine kinase activity


regulation of platelet-derived growth factor receptor signaling pathway


negative regulation of vitamin D biosynthetic process


regulation of skeletal muscle adaptation


regulation of microtubule polymerization or depolymerization


negative regulation of interleukin-6 production


metanephric part of ureteric bud development


photoreceptor cell outer segment organization


negative regulation of CD4-positive, alpha-beta T cell differentiation


regulation of CD8-positive, alpha-beta T cell differentiation


negative regulation of T-helper cell differentiation


negative regulation of alpha-beta T cell activation


negative regulation of alpha-beta T cell differentiation


positive regulation of developmental pigmentation


regulation of pigment cell differentiation


positive regulation of DNA-binding transcription factor activity


positive regulation of NF-kappaB transcription factor activity


cellular response to arsenic-containing substance


regulation of establishment of planar polarity


negative regulation of protein localization to nucleus


regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning


negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning


negative regulation of membrane depolarization


regulation of non-canonical Wnt signaling pathway


negative regulation of non-canonical Wnt signaling pathway


regulation of CD4-positive, alpha-beta T cell activation


negative regulation of CD4-positive, alpha-beta T cell activation


negative regulation of hepatocyte apoptotic process


positive regulation of CD8-positive, alpha-beta T cell differentiation


positive regulation of lymphocyte anergy


positive regulation of vitamin D receptor signaling pathway


purine nucleoside monophosphate catabolic process


regulation of hepatocyte apoptotic process


ribonucleoside monophosphate catabolic process


G protein-coupled receptor dimeric complex


cAMP response element binding protein binding


cytochrome-b5 reductase activity, acting on NAD(P)H


ligase activity, forming carbon-oxygen bonds


aspartate family amino acid metabolic process


CD163 mediating an anti-inflammatory response (Homo sapiens)


IL-6-type cytokine receptor ligand interactions (Homo sapiens)


InlB-mediated entry of Listeria monocytogenes into host cell (Homo sapiens)


Interleukin receptor SHC signaling (Homo sapiens)


Listeria monocytogenes entry into host cells (Homo sapiens)


Mitochondrial tRNA aminoacylation (Homo sapiens)


Molybdenum cofactor biosynthesis (Homo sapiens)


Negative epigenetic regulation of rRNA expression (Homo sapiens)


Recognition and association of DNA glycosylase with site containing an affected purine (Homo sapiens)


Toxicity of botulinum toxin type D (botD) (Homo sapiens)


Transport of the SLBP Dependant Mature mRNA (Homo sapiens)


transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery


positive regulation of cytokine production involved in immune response


positive regulation of dendritic cell cytokine production


MyD88-dependent toll-like receptor signaling pathway


protein catabolic process in the vacuole


positive regulation of keratinocyte proliferation


cerebellar Purkinje cell layer development


hindbrain radial glia guided cell migration


microtubule organizing center organization


N-terminal protein amino acid modification


regulation of synaptic transmission, cholinergic


positive regulation of mast cell activation


positive regulation of mast cell activation involved in immune response


positive regulation of amine metabolic process


common myeloid progenitor cell proliferation


regulation of CD4-positive, alpha-beta T cell differentiation


regulation of T-helper cell differentiation


positive regulation of T-helper cell differentiation


regulation of T-helper 1 cell differentiation


negative regulation of osteoclast differentiation


positive regulation of epidermal growth factor-activated receptor activity


positive regulation of striated muscle contraction


regulation of mitotic centrosome separation


positive regulation of alpha-beta T cell proliferation


negative regulation of dendrite morphogenesis


regulation of syncytium formation by plasma membrane fusion


regulation of growth hormone receptor signaling pathway


positive regulation of cardiac muscle contraction


pattern specification involved in kidney development


regulation of establishment of protein localization to chromosome


negative regulation of stress-activated protein kinase signaling cascade


nephron tubule epithelial cell differentiation


plus-end-directed organelle transport along microtubule


mitochondrial outer membrane permeabilization


negative regulation of cellular response to hypoxia


regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway


positive regulation of ERBB signaling pathway


regulation of mitochondrial membrane permeability involved in apoptotic process


negative regulation of response to oxidative stress


positive regulation of vascular associated smooth muscle cell proliferation


regulation of lymphoid progenitor cell differentiation


positive regulation of membrane permeability


positive regulation of CD4-positive, alpha-beta T cell activation


negative regulation of endothelial cell chemotaxis


mitochondrial outer membrane permeabilization involved in programmed cell death


negative regulation of response to reactive oxygen species


positive regulation of enamel mineralization


positive regulation of hematopoietic progenitor cell differentiation


positive regulation of NMDA glutamate receptor activity


positive regulation of syncytium formation by plasma membrane fusion


regulation of cytoplasmic translational elongation


regulation of pro-B cell differentiation


nucleotide-activated protein kinase complex


inositol hexakisphosphate kinase activity


lactate transmembrane transporter activity


oxidoreductase activity, acting on metal ions


plus-end-directed microtubule motor activity


tRNA (guanine) methyltransferase activity


type 2 fibroblast growth factor receptor binding


BBSome-mediated cargo-targeting to cilium (Homo sapiens)


nucleotide-excision repair, DNA damage recognition


Fibronectin matrix formation (Homo sapiens)


Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)


Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)


POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation (Homo sapiens)


Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)


Resolution of D-Loop Structures (Homo sapiens)


SHC1 events in EGFR signaling (Homo sapiens)


nucleoside diphosphate catabolic process


positive regulation of phospholipase activity


endosome transport via multivesicular body sorting pathway


positive regulation of interleukin-17 production


regulation of odontogenesis of dentin-containing tooth


maintenance of presynaptic active zone structure


attachment of mitotic spindle microtubules to kinetochore


positive regulation of autophagy of mitochondrion


positive regulation of membrane depolarization


regulation of store-operated calcium entry


adenylate cyclase-inhibiting serotonin receptor signaling pathway


positive regulation of potassium ion import across plasma membrane


purine nucleoside diphosphate catabolic process


regulation of membrane depolarization during cardiac muscle cell action potential


ribonucleoside diphosphate catabolic process


mRNA cleavage and polyadenylation specificity factor complex


GABA-gated chloride ion channel activity


inhibitory extracellular ligand-gated monoatomic ion channel activity


intracellularly cAMP-activated cation channel activity


structural constituent of presynaptic active zone


DCC mediated attractive signaling (Homo sapiens)


Netrin mediated repulsion signals (Homo sapiens)


p75NTR recruits signalling complexes (Homo sapiens)


Processing and activation of SUMO (Homo sapiens)


Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)


RHO GTPases activate KTN1 (Homo sapiens)


Signaling by membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)


Signalling to p38 via RIT and RIN (Homo sapiens)


SUMO is conjugated to E1 (UBA2:SAE1) (Homo sapiens)


SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Homo sapiens)


Translesion synthesis by POLK (Homo sapiens)


negative regulation of acute inflammatory response to antigenic stimulus


negative regulation of norepinephrine secretion


positive regulation of nucleotide biosynthetic process


positive regulation of translation in response to stress


negative regulation of protein-containing complex disassembly


positive regulation by host of viral genome replication


positive regulation of MHC class II biosynthetic process


negative regulation of nucleocytoplasmic transport


platelet-derived growth factor receptor signaling pathway


regulation of mitochondrial membrane potential


antimicrobial humoral immune response mediated by antimicrobial peptide


chromosome organization involved in meiotic cell cycle


negative regulation of fat cell proliferation


maintenance of protein localization in organelle


regulation of flagellated sperm motility


negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage


positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway


negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator


negative regulation of chromatin organization


regulation of type B pancreatic cell development


inositol trisphosphate metabolic process


lymphocyte migration into lymphoid organs


neutrophil activation involved in immune response


positive regulation of 3'-UTR-mediated mRNA stabilization


regulation of histamine secretion by mast cell


regulation of integrin biosynthetic process


aromatic amino acid transmembrane transporter activity


glutathione transmembrane transporter activity


ATP-dependent protein disaggregase activity


protein tyrosine kinase inhibitor activity


transmembrane receptor protein phosphatase activity


tripeptide transmembrane transporter activity


water transmembrane transporter activity


Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)


Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)


Formyl peptide receptors bind formyl peptides and many other ligands (Homo sapiens)


p75 NTR receptor-mediated signalling (Homo sapiens)


Sodium-coupled phosphate cotransporters (Homo sapiens)


SUMOylation of chromatin organization proteins (Homo sapiens)


organ or tissue specific immune response


T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell


regulation of double-strand break repair via homologous recombination


negative regulation of microtubule polymerization or depolymerization


positive regulation of toll-like receptor signaling pathway


positive regulation of toll-like receptor 4 signaling pathway


intrinsic apoptotic signaling pathway in response to hydrogen peroxide


positive regulation of myoblast differentiation


negative regulation of G protein-coupled receptor signaling pathway


negative regulation of innate immune response


regulation of nucleocytoplasmic transport


regulation of skeletal muscle tissue growth


positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction


establishment of protein localization to plasma membrane


nucleotide-binding oligomerization domain containing 2 signaling pathway


monoatomic cation transmembrane transport


vesicle-mediated transport to the plasma membrane


endosome to plasma membrane protein transport


regulation of bone mineralization involved in bone maturation


positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis


negative regulation of anion transmembrane transport


regulation of monoatomic cation transmembrane transport


negative regulation of double-strand break repair via homologous recombination


regulation of double-strand break repair


adenylate cyclase-activating adrenergic receptor signaling pathway


amino acid import across plasma membrane


positive regulation of pattern recognition receptor signaling pathway


pyrimidine ribonucleotide metabolic process


serotonin-activated cation-selective channel complex


alanine transmembrane transporter activity


amino acid transmembrane transporter activity


branched-chain amino acid transmembrane transporter activity


double-stranded RNA adenosine deaminase activity


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines


L-amino acid transmembrane transporter activity


L-histidine transmembrane transporter activity


macromolecule transmembrane transporter activity


neutral L-amino acid transmembrane transporter activity


oligopeptide transmembrane transporter activity


peptide transmembrane transporter activity


serotonin-gated monoatomic cation channel activity


tRNA-specific adenosine deaminase activity


Depolymerization of the Nuclear Lamina (Homo sapiens)


Diseases of Immune System (Homo sapiens)


G alpha (i) signalling events (Homo sapiens)


IRAK4 deficiency (TLR2/4) (Homo sapiens)


Nephrin family interactions (Homo sapiens)


Peptide ligand-binding receptors (Homo sapiens)


Rab regulation of trafficking (Homo sapiens)


Regulation of TLR by endogenous ligand (Homo sapiens)


symbiont-mediated suppression of host innate immune response


RNA polymerase I preinitiation complex assembly


positive regulation of neuroblast proliferation


determination of left/right asymmetry in lateral mesoderm


transcription initiation at RNA polymerase I promoter


negative regulation of peptidase activity


positive regulation of BMP signaling pathway


regulation of nucleotide biosynthetic process


positive regulation of maintenance of sister chromatid cohesion


positive regulation of Rho protein signal transduction


negative regulation of MAP kinase activity


regulation of osteoclast differentiation


positive regulation of Notch signaling pathway


negative regulation of calcium ion-dependent exocytosis


positive regulation of small GTPase mediated signal transduction


negative regulation of cyclic-nucleotide phosphodiesterase activity


negative regulation of hydrolase activity


intracellular protein transmembrane transport


transcription preinitiation complex assembly


protein localization to microtubule organizing center


positive regulation of neural precursor cell proliferation


anterograde axonal transport of mitochondrion


ossification involved in bone remodeling


inner mitochondrial membrane protein complex


monoatomic anion:sodium symporter activity


protein carboxyl O-methyltransferase activity


RNA polymerase I general transcription initiation factor activity


RNA polymerase I transcription regulatory region sequence-specific DNA binding


RNA polymerase III transcription regulatory region sequence-specific DNA binding


sulfate transmembrane transporter activity


Activated NTRK2 signals through CDK5 (Homo sapiens)


Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)


Chaperone Mediated Autophagy (Homo sapiens)


MyD88-independent TLR4 cascade  (Homo sapiens)


Regulation of RAS by GAPs (Homo sapiens)


rRNA modification in the nucleus and cytosol (Homo sapiens)


Signaling by MRAS-complex mutants (Homo sapiens)


Sphingolipid de novo biosynthesis (Homo sapiens)


Toll-like Receptor Cascades (Homo sapiens)


regulation of amino acid metabolic process


substrate-dependent cell migration, cell extension


nucleoside diphosphate biosynthetic process


purine nucleoside diphosphate biosynthetic process


positive regulation of transporter activity


positive regulation of integrin activation


positive regulation of T cell receptor signaling pathway


neuromuscular process controlling balance


biological process involved in intraspecies interaction between organisms


regulation of cilium beat frequency involved in ciliary motility


pyrimidine-containing compound metabolic process


pyrimidine-containing compound catabolic process


regulation of cellular response to osmotic stress


positive regulation of epithelial cell apoptotic process


regulation of protein catabolic process in the vacuole


regulation of lysosomal protein catabolic process


negative regulation of stem cell proliferation


positive regulation of cation channel activity


cellular response to bacterial lipoprotein


deoxyribonucleoside diphosphate metabolic process


negative regulation of T-helper 17 type immune response


positive regulation of dendritic cell differentiation


purine deoxyribonucleotide metabolic process


regulation of intrinsic apoptotic signaling pathway in response to osmotic stress


active monoatomic ion transmembrane transporter activity


active transmembrane transporter activity


cadherin binding involved in cell-cell adhesion


sodium-independent organic anion transmembrane transporter activity


HuR (ELAVL1) binds and stabilizes mRNA (Homo sapiens)


NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis  (Homo sapiens)


SUMO is proteolytically processed (Homo sapiens)


VxPx cargo-targeting to cilium (Homo sapiens)


positive regulation of leukocyte chemotaxis


N-terminal protein amino acid acetylation


homophilic cell adhesion via plasma membrane adhesion molecules


aspartate family amino acid biosynthetic process


serine family amino acid biosynthetic process


regulation of skeletal muscle contraction by calcium ion signaling


regulation of skeletal muscle contraction


positive regulation of microtubule polymerization or depolymerization


negative regulation of fatty acid beta-oxidation


pteridine-containing compound metabolic process


negative regulation of calcium-mediated signaling


negative regulation of transcription initiation by RNA polymerase II


chemokine (C-C motif) ligand 5 production


negative regulation of calcineurin-mediated signaling


negative regulation of RNA catabolic process


negative regulation of leukocyte adhesion to vascular endothelial cell


folic acid-containing compound metabolic process


negative regulation of hair follicle development


regulation of microtubule cytoskeleton organization


N-terminal protein acetyltransferase complex


dicarboxylic acid transmembrane transporter activity


hydrolase activity, acting on acid anhydrides


secondary active transmembrane transporter activity


solute:monoatomic cation symporter activity


Acetylcholine Neurotransmitter Release Cycle (Homo sapiens)


Activation of the AP-1 family of transcription factors (Homo sapiens)


Carboxyterminal post-translational modifications of tubulin (Homo sapiens)


DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)


Formation of Incision Complex in GG-NER (Homo sapiens)


negative regulation of type I interferon production


RHO GTPases Activate NADPH Oxidases (Homo sapiens)


maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)


respiratory gaseous exchange by respiratory system


intrinsic apoptotic signaling pathway in response to oxidative stress


negative regulation of myotube differentiation


negative regulation of glucocorticoid metabolic process


nucleobase-containing small molecule biosynthetic process


protein localization to nuclear envelope


regulation of postsynaptic membrane neurotransmitter receptor levels


positive regulation of organelle assembly


regulation of oxidative stress-induced intrinsic apoptotic signaling pathway


positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage


positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator


regulation of response to oxidative stress


positive regulation of glycoprotein metabolic process


regulation of autophagy of mitochondrion


regulation of protein localization to cilium


regulation of establishment of protein localization to mitochondrion


positive regulation of establishment of protein localization to mitochondrion


regulation of cytoplasmic translational initiation


positive regulation of T-helper 17 type immune response


ganglioside biosynthetic process via lactosylceramide


neurotransmitter receptor transport to plasma membrane


regulation of calcium ion import across plasma membrane


regulation of T-helper 17 cell differentiation


endoplasmic reticulum quality control compartment


L-serine transmembrane transporter activity


ubiquitin-like protein transferase activity


voltage-gated monoatomic cation channel activity


ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)


Cytosolic tRNA aminoacylation (Homo sapiens)


Nectin/Necl  trans heterodimerization (Homo sapiens)


SIRT1 negatively regulates rRNA expression (Homo sapiens)


TRAF6 mediated NF-kB activation (Homo sapiens)


beta-hydroxybutyric acid measurement

biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


cellular component disassembly involved in execution phase of apoptosis


granulocyte macrophage colony-stimulating factor production


cell migration involved in kidney development


regulation of cardiac muscle cell membrane potential


regulation of protein polyubiquitination


regulation of mesodermal cell differentiation


positive regulation of double-strand break repair via nonhomologous end joining


cell migration involved in metanephros development


flavin-containing compound metabolic process


positive regulation of ATPase-coupled calcium transmembrane transporter activity


calcium-activated cation channel activity


monoatomic cation transmembrane transporter activity


oxidoreductase activity, acting on a sulfur group of donors


polyubiquitin modification-dependent protein binding


activated TAK1 mediates p38 MAPK activation (Homo sapiens)


Activation of ATR in response to replication stress (Homo sapiens)


Calnexin/calreticulin cycle (Homo sapiens)


Detoxification of Reactive Oxygen Species (Homo sapiens)


Downregulation of ERBB4 signaling (Homo sapiens)


FGFR3b ligand binding and activation (Homo sapiens)


NF-kB is activated and signals survival (Homo sapiens)


Prevention of phagosomal-lysosomal fusion (Homo sapiens)


Prostanoid ligand receptors (Homo sapiens)


Respiratory electron transport (Homo sapiens)


TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)


regulation of systemic arterial blood pressure by vasopressin


cytoplasmic pattern recognition receptor signaling pathway


negative regulation of calcium ion transport into cytosol


negative regulation of Schwann cell proliferation


regulation of cardiac muscle contraction by calcium ion signaling


mitotic intra-S DNA damage checkpoint signaling


ATP synthesis coupled electron transport


Golgi to plasma membrane protein transport


double-strand break repair via single-strand annealing


positive regulation of sequestering of calcium ion


negative regulation of glial cell proliferation


negative regulation of cell growth involved in cardiac muscle cell development


positive regulation of protein polyubiquitination


regulation of caveolin-mediated endocytosis


positive regulation of antimicrobial humoral response


positive regulation of hydrogen peroxide metabolic process


pyrimidine nucleoside monophosphate catabolic process


response to diacyl bacterial lipopeptide


extrinsic component of endoplasmic reticulum membrane


calcium-dependent protein serine/threonine phosphatase regulator activity


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen


oxidoreduction-driven active transmembrane transporter activity


Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)


negative regulation of epidermal growth factor receptor signaling pathway


Signaling by Erythropoietin (Homo sapiens)


Synthesis of wybutosine at G37 of tRNA(Phe) (Homo sapiens)


Zinc influx into cells by the SLC39 gene family (Homo sapiens)


nucleoside monophosphate catabolic process


purine nucleoside monophosphate metabolic process


positive regulation of chromatin binding


metaphase/anaphase transition of cell cycle


negative regulation of viral genome replication


negative regulation of membrane potential


antigen processing and presentation, endogenous lipid antigen via MHC class Ib


regulation of dopamine uptake involved in synaptic transmission


catecholamine uptake involved in synaptic transmission


regulation of programmed necrotic cell death


cellular response to prostaglandin E stimulus


negative regulation of metaphase/anaphase transition of cell cycle


negative regulation of mitochondrial membrane permeability involved in apoptotic process


positive regulation of protein modification by small protein conjugation or removal


myeloid dendritic cell cytokine production


protein localization to condensed chromosome


regulation of mitotic sister chromatid segregation


H4/H2A histone acetyltransferase complex


cyclic nucleotide-dependent protein kinase activity


protein serine/threonine phosphatase inhibitor activity


Constitutive Signaling by EGFRvIII (Homo sapiens)


FGFR1 ligand binding and activation (Homo sapiens)


Nucleotide-like (purinergic) receptors (Homo sapiens)


Regulation of FZD by ubiquitination (Homo sapiens)


Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)


Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)


intrinsic apoptotic signaling pathway in response to osmotic stress


negative regulation of cell fate commitment


positive regulation of cell fate commitment


positive regulation of synaptic plasticity


regulation of secondary metabolic process


secondary metabolite biosynthetic process


regulation of synapse structural plasticity


positive regulation of amino acid transport


monocyte chemotactic protein-1 production


cell-cell adhesion via plasma-membrane adhesion molecules


regulation of dopaminergic neuron differentiation


regulation of entry of bacterium into host cell


enzyme-directed rRNA pseudouridine synthesis


folic acid-containing compound catabolic process


negative regulation of chemokine (C-C motif) ligand 5 production


positive regulation of bicellular tight junction assembly


proteasome regulatory particle, lid subcomplex


ATP-dependent chromatin remodeler activity


oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor


protein-disulfide reductase [NAD(P)H] activity


Defective factor IX causes hemophilia B (Homo sapiens)


Signaling by LRP5 mutants  (Homo sapiens)


Termination of O-glycan biosynthesis (Homo sapiens)


Fc receptor mediated stimulatory signaling pathway


positive regulation of calcium ion-dependent exocytosis


retina vasculature morphogenesis in camera-type eye


tRNA threonylcarbamoyladenosine metabolic process


response to gonadotropin-releasing hormone


positive regulation of cytokine production involved in inflammatory response


regulation of substrate adhesion-dependent cell spreading


regulation of hepatic stellate cell activation


regulation of Rho-dependent protein serine/threonine kinase activity


N6-methyladenosine-containing RNA reader activity


Activation of AMPK downstream of NMDARs (Homo sapiens)


ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)


CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)


Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)


Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Homo sapiens)


Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)


RHO GTPases activate IQGAPs (Homo sapiens)


rRNA processing in the mitochondrion (Homo sapiens)


Trafficking and processing of endosomal TLR (Homo sapiens)


double-strand break repair via break-induced replication


negative regulation of transcription by competitive promoter binding


positive regulation of DNA-templated transcription, elongation


positive regulation of intracellular steroid hormone receptor signaling pathway


regulation of T cell receptor signaling pathway


positive regulation of gonad development


postsynapse to nucleus signaling pathway


resolution of DNA recombination intermediates


protein-N-terminal amino-acid acetyltransferase activity


protein tyrosine/threonine phosphatase activity


type 1 fibroblast growth factor receptor binding


glutathione derivative biosynthetic process


HIV elongation arrest and recovery (Homo sapiens)


Passive transport by Aquaporins (Homo sapiens)


Platelet calcium homeostasis (Homo sapiens)


Reduction of cytosolic Ca++ levels (Homo sapiens)


Sodium/Calcium exchangers (Homo sapiens)


nucleoside triphosphate metabolic process


nucleoside triphosphate biosynthetic process


ribonucleoside triphosphate biosynthetic process


establishment or maintenance of transmembrane electrochemical gradient


cerebral cortex radially oriented cell migration


negative regulation of actin filament depolymerization


response to follicle-stimulating hormone


positive regulation of dopamine receptor signaling pathway


metanephric glomerulus vasculature development


purine-containing compound catabolic process


negative regulation of fibroblast apoptotic process


negative regulation of stem cell differentiation


positive regulation of protein K63-linked ubiquitination


positive regulation of pseudopodium assembly


pyrimidine nucleoside triphosphate metabolic process


ribonucleoside triphosphate metabolic process


peptidase activator activity involved in apoptotic process


Eicosanoid ligand-binding receptors (Homo sapiens)


Synthesis of PIPs at the Golgi membrane (Homo sapiens)


TICAM1, RIP1-mediated IKK complex recruitment (Homo sapiens)


regulation of glutamine family amino acid metabolic process


pentose-phosphate shunt, non-oxidative branch


phenol-containing compound metabolic process


positive regulation of natural killer cell proliferation


phenol-containing compound biosynthetic process


regulation of pancreatic juice secretion


inorganic ion import across plasma membrane


negative regulation of serine-type peptidase activity


regulation of T-helper 17 cell lineage commitment


negative regulation of reactive oxygen species metabolic process


calcium-dependent cysteine-type endopeptidase activity


single-stranded DNA exodeoxyribonuclease activity


Budding and maturation of HIV virion (Homo sapiens)


regulation of type I interferon production


regulation of blood volume by renin-angiotensin


regulation of systemic arterial blood pressure mediated by a chemical signal


negative regulation of keratinocyte differentiation


detection of chemical stimulus involved in sensory perception of taste


establishment of pigment granule localization


regulation of ryanodine-sensitive calcium-release channel activity


response to cell cycle checkpoint signaling


regulation of DNA-templated DNA replication


trans-synaptic signaling, modulating synaptic transmission


regulation of mitochondrial ATP synthesis coupled electron transport


5-phosphoribose 1-diphosphate metabolic process


diphosphoinositol polyphosphate metabolic process


ethanolamine-containing compound metabolic process


guanine nucleotide transmembrane transport


succinate transmembrane transporter activity


Export of Viral Ribonucleoproteins from Nucleus (Homo sapiens)


Nuclear Pore Complex (NPC) Disassembly (Homo sapiens)


SUMOylation of ubiquitinylation proteins (Homo sapiens)


positive regulation of dendritic cell antigen processing and presentation


G protein-coupled dopamine receptor signaling pathway


serine family amino acid metabolic process


serine family amino acid catabolic process


positive regulation of actin filament polymerization


regulation of natural killer cell activation


positive regulation of natural killer cell activation


nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway


negative regulation of erythrocyte differentiation


intracellular distribution of mitochondria


regulation of antigen receptor-mediated signaling pathway


negative regulation of antigen receptor-mediated signaling pathway


negative regulation of T cell receptor signaling pathway


vascular associated smooth muscle cell development


regulation of protein autoubiquitination


positive regulation of T-helper 17 cell differentiation


negative regulation of interleukin-1 alpha production


negative regulation of prostaglandin biosynthetic process


positive regulation of innate immune response


cAMP-dependent protein kinase inhibitor activity


cAMP-dependent protein kinase regulator activity


Diseases associated with N-glycosylation of proteins (Homo sapiens)


Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)


Fc epsilon receptor (FCERI) signaling (Homo sapiens)


Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)


Methionine salvage pathway (Homo sapiens)


PERK regulates gene expression (Homo sapiens)


Processive synthesis on the C-strand of the telomere (Homo sapiens)


TAK1-dependent IKK and NF-kappa-B activation   (Homo sapiens)


TNFR1-induced NF-kappa-B signaling pathway (Homo sapiens)


Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)


MyD88-independent toll-like receptor signaling pathway


deoxyribonucleoside triphosphate biosynthetic process


negative regulation of mitochondrial fusion


cerebellar Purkinje cell layer formation


cellular process involved in reproduction in multicellular organism


positive regulation of antigen receptor-mediated signaling pathway


negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway


negative regulation of membrane permeability


intrinsic apoptotic signaling pathway in response to hypoxia


oligopeptide import across plasma membrane


pyrimidine deoxyribonucleotide metabolic process


regulation of mitochondrial electron transport, NADH to ubiquinone


regulation of synaptic vesicle membrane organization


ATPase-coupled ion transmembrane transporter activity


Diseases associated with glycosylation precursor biosynthesis (Homo sapiens)


N-glycan trimming and elongation in the cis-Golgi (Homo sapiens)


nucleobase-containing small molecule interconversion


cerebellar Purkinje cell layer morphogenesis


sodium ion export across plasma membrane


regulation of cellular response to vascular endothelial growth factor stimulus


positive regulation of protein localization to cilium


negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis


bicarbonate transmembrane transporter activity


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen


P-type potassium transmembrane transporter activity


phosphotransferase activity, for other substituted phosphate groups


formation of extrachromosomal circular DNA


positive regulation of systemic arterial blood pressure


protein import into mitochondrial matrix


positive regulation of toll-like receptor 2 signaling pathway


negative regulation of smooth muscle cell apoptotic process


epithelial cilium movement involved in determination of left/right asymmetry


regulation of bile acid biosynthetic process


regulation of protein localization to centrosome


positive regulation of ubiquitin-dependent protein catabolic process


positive regulation of Rac protein signal transduction


outer mitochondrial membrane protein complex


chloride:monoatomic cation symporter activity


Biotin transport and metabolism (Homo sapiens)


Cation-coupled Chloride cotransporters (Homo sapiens)


Diseases of carbohydrate metabolism (Homo sapiens)


Interactions of Rev with host cellular proteins (Homo sapiens)


Nuclear import of Rev protein (Homo sapiens)


PINK1-PRKN Mediated Mitophagy (Homo sapiens)


SUMOylation of DNA replication proteins (Homo sapiens)


SUMOylation of RNA binding proteins (Homo sapiens)


SUMOylation of SUMOylation proteins (Homo sapiens)


regulation of miRNA-mediated gene silencing


Viral Messenger RNA Synthesis (Homo sapiens)


regulation of transcription by RNA polymerase III


purine deoxyribonucleotide catabolic process


regulation of guanylate cyclase activity


negative regulation of single stranded viral RNA replication via double stranded DNA intermediate


purine deoxyribonucleoside monophosphate metabolic process


regulation of snRNA transcription by RNA polymerase II


phosphatidylinositol trisphosphate phosphatase activity


superoxide-generating NAD(P)H oxidase activity


Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (Homo sapiens)


Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)


EPH-ephrin mediated repulsion of cells (Homo sapiens)


physiological cardiac muscle hypertrophy


positive regulation of activin receptor signaling pathway


negative regulation of myoblast differentiation


negative regulation of protein exit from endoplasmic reticulum


cellular response to purine-containing compound


determination of digestive tract left/right asymmetry


negative regulation of cell proliferation involved in kidney development


peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity


positive regulation of phospholipid metabolic process


oxidoreductase activity, acting on single donors with incorporation of molecular oxygen


IKK complex recruitment mediated by RIP1 (Homo sapiens)


NADE modulates death signalling (Homo sapiens)


regulation of translation in response to endoplasmic reticulum stress


RNA polymerase II preinitiation complex assembly


regulation of vitamin D receptor signaling pathway


positive regulation of cell proliferation involved in heart morphogenesis


hypothalamus gonadotrophin-releasing hormone neuron differentiation


negative regulation of B cell differentiation


positive regulation of G0 to G1 transition


ribosome-associated ubiquitin-dependent protein catabolic process


nucleoside triphosphate diphosphatase activity


monoatomic cation:bicarbonate symporter activity


structural constituent of skin epidermis


NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose (Homo sapiens)


transcription elongation by RNA polymerase III


determination of pancreatic left/right asymmetry


negative regulation of monocyte chemotaxis


negative regulation of mRNA metabolic process


Defects in vitamin and cofactor metabolism (Homo sapiens)


Phosphate bond hydrolysis by NTPDase proteins (Homo sapiens)


Processing of Capped Intronless Pre-mRNA (Homo sapiens)


spinal cord association neuron differentiation


negative regulation of synaptic transmission, GABAergic


G protein-coupled purinergic nucleotide receptor signaling pathway


monoatomic anion:monoatomic cation symporter activity


G protein-coupled purinergic nucleotide receptor activity


negative regulation of cell fate specification


indole-containing compound biosynthetic process


regulation of protein monoubiquitination


catechol-containing compound biosynthetic process


calcium-dependent phospholipase A2 activity


neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential


KSRP (KHSRP) binds and destabilizes mRNA (Homo sapiens)


positive regulation of mitochondrial translation


positive regulation of catecholamine metabolic process


endoplasmic reticulum tubular network membrane


APOBEC3G mediated resistance to HIV-1 infection (Homo sapiens)


regulation of synaptic assembly at neuromuscular junction


gastro-intestinal system smooth muscle contraction


synaptic assembly at neuromuscular junction


positive regulation of digestive system process


cortical actin cytoskeleton organization


innate immune response-activating signaling pathway


cyclin/CDK positive transcription elongation factor complex


3-hydroxyacyl-CoA dehydrogenase (NAD+) activity


E2F mediated regulation of DNA replication (Homo sapiens)


Interactions of Vpr with host cellular proteins (Homo sapiens)


PI3K events in ERBB4 signaling (Homo sapiens)


positive regulation of organic acid transport


positive regulation of glucokinase activity


positive regulation of skeletal muscle fiber development


regulation of polyamine transmembrane transport


positive regulation of hexokinase activity


negative regulation of mRNA catabolic process


ribonucleoside diphosphate biosynthetic process


histone H3K9me/H3K9me2 demethylase activity


hydroperoxy icosatetraenoate dehydratase activity


ornithine decarboxylase regulator activity


cardiac muscle cell-cardiac muscle cell adhesion


positive regulation of acrosome reaction


ribose phosphate diphosphokinase complex


L-lysine transmembrane transporter activity


ribose phosphate diphosphokinase activity


ubiquitin-like protein-specific endopeptidase activity


RHO GTPases Activate WASPs and WAVEs (Homo sapiens)


biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

Dementia associated with Parkinson's Disease


nucleoside monophosphate metabolic process


regulation of DNA-templated DNA replication initiation


clustering of voltage-gated sodium channels


pyridine-containing compound metabolic process


pyridine-containing compound biosynthetic process


cellular response to brain-derived neurotrophic factor stimulus


deoxyribonucleoside monophosphate catabolic process


17-beta-hydroxysteroid dehydrogenase (NADP+) activity


histone H3K27me2/H3K27me3 demethylase activity


nucleobase-containing compound kinase activity


nucleoside monophosphate kinase activity


secondary active monocarboxylate transmembrane transporter activity


Signaling by RNF43 mutants (Homo sapiens)


TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)


positive regulation of myeloid leukocyte mediated immunity


eukaryotic translation initiation factor 3 complex


acyltransferase activity, acyl groups converted into alkyl on transfer


aldehyde dehydrogenase [NAD(P)+] activity


Role of ABL in ROBO-SLIT signaling (Homo sapiens)


meiotic sister chromatid cohesion, centromeric


positive regulation of protein glycosylation


negative regulation of skeletal muscle cell differentiation


Beta-oxidation of very long chain fatty acids (Homo sapiens)


regulation of monoatomic anion transmembrane transport


negative regulation of myoblast proliferation


positive regulation of centriole elongation


positive regulation of platelet aggregation


cilium or flagellum-dependent cell motility


calcium activated phospholipid scrambling


pyrimidine ribonucleoside triphosphate metabolic process


eukaryotic translation initiation factor 3 complex, eIF3m


extracellular matrix structural constituent conferring compression resistance


Regulation of HSF1-mediated heat shock response (Homo sapiens)


tRNA processing in the nucleus (Homo sapiens)


regulation of translational initiation by eIF2 alpha phosphorylation


negative regulation of translational initiation


regulation of translation initiation in response to endoplasmic reticulum stress


protein binding involved in heterotypic cell-cell adhesion


transmembrane receptor protein tyrosine kinase activator activity


Interaction between L1 and Ankyrins (Homo sapiens)


pyrimidine nucleoside diphosphate biosynthetic process


regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay


GABA synthesis, release, reuptake and degradation (Homo sapiens)


HSF1-dependent transactivation (Homo sapiens)


Polymerase switching on the C-strand of the telomere (Homo sapiens)


Defective B4GALT7 causes EDS, progeroid type (Homo sapiens)


pyrimidine nucleoside triphosphate biosynthetic process


neurotransmitter receptor transport, endosome to postsynaptic membrane


NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)


natural killer cell activation involved in immune response


positive regulation of natural killer cell chemotaxis


hydroxymethyl-, formyl- and related transferase activity


AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)


Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)


positive regulation of guanylate cyclase activity


CD8-positive, alpha-beta T cell proliferation


sodium ion import across plasma membrane


negative regulation of DNA-templated transcription initiation


Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)


protein transmembrane import into intracellular organelle


proton motive force-driven mitochondrial ATP synthesis


glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity


oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor


potassium ion transmembrane transporter activity


voltage-gated sodium channel activity involved in cardiac muscle cell action potential


negative regulation of hydrogen peroxide metabolic process


rRNA (adenine) methyltransferase activity


folic acid-containing compound biosynthetic process


pteridine-containing compound biosynthetic process


ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway


pyridine nucleotide biosynthetic process


MAP kinase kinase kinase kinase activity


positive regulation of chromosome segregation


embryonic process involved in female pregnancy


regulation of cell growth involved in cardiac muscle cell development


positive regulation of phospholipid biosynthetic process


glial cell-derived neurotrophic factor receptor activity


indole-containing compound metabolic process


primary amino compound metabolic process


pyrimidine deoxyribonucleoside triphosphate metabolic process


Metabolism of amino acids and derivatives (Homo sapiens)


regulation of centromere complex assembly


regulation of G2/M transition of mitotic cell cycle


Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)


regulation of mitotic spindle organization


spliceosomal conformational changes to generate catalytic conformation


cerebellar Purkinje cell-granule cell precursor cell signaling


positive regulation of cerebellar granule cell precursor proliferation


D-aspartate import across plasma membrane


Muscarinic acetylcholine receptors (Homo sapiens)


Platelet Adhesion to exposed collagen (Homo sapiens)


regulation of synaptic vesicle endocytosis


RNA Polymerase III Transcription Initiation From Type 3 Promoter (Homo sapiens)


The activation of arylsulfatases (Homo sapiens)


positive regulation of transcription by RNA polymerase III


Ficolins bind to repetitive carbohydrate structures on the target cell surface (Homo sapiens)


aorta smooth muscle tissue morphogenesis


ATF4 activates genes in response to endoplasmic reticulum  stress (Homo sapiens)


negative regulation of DNA recombination at telomere


regulation of systemic arterial blood pressure by circulatory renin-angiotensin


histamine production involved in inflammatory response


protoporphyrinogen IX biosynthetic process


ubiquitin-dependent glycoprotein ERAD pathway


nucleoside diphosphate phosphatase activity


regulation of systemic arterial blood pressure by norepinephrine-epinephrine


thioredoxin-disulfide reductase (NADPH) activity


JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1 (Homo sapiens)


regulation of removal of superoxide radicals


negative regulation of CD4-positive, alpha-beta T cell proliferation


regulation of amino acid transmembrane transport


transcription elongation factor activity


Transport of connexons to the plasma membrane (Homo sapiens)


maternal process involved in parturition


Synaptic adhesion-like molecules (Homo sapiens)


Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)


detection of light stimulus involved in sensory perception


calcium sensitive guanylate cyclase activator activity


carbon-nitrogen ligase activity, with glutamine as amido-N-donor


proton-transporting two-sector ATPase complex, catalytic domain


proton-transporting V-type ATPase, V1 domain


fusion of sperm to egg plasma membrane involved in single fertilization


negative regulation of cell cycle G2/M phase transition


cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication


riboflavin transmembrane transporter activity


PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)


negative regulation of oxidoreductase activity


gamma-aminobutyric acid transmembrane transporter activity


Apoptotic cleavage of cell adhesion  proteins (Homo sapiens)


cyclic nucleotide-activated monoatomic ion channel activity


structural constituent of postsynaptic actin cytoskeleton


Amine ligand-binding receptors (Homo sapiens)


Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Homo sapiens)


fatty acid beta-oxidation using acyl-CoA oxidase


negative regulation of helicase activity


RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism


Nef Mediated CD8 Down-regulation (Homo sapiens)


diphosphate hydrolysis-driven proton transmembrane transporter activity


Abortive elongation of HIV-1 transcript in the absence of Tat (Homo sapiens)


water-soluble vitamin biosynthetic process


modification of postsynaptic actin cytoskeleton


nucleoside triphosphate catabolic process


positive regulation of receptor clustering


Processing of Intronless Pre-mRNAs (Homo sapiens)


CD4-positive, alpha-beta T cell proliferation


Role of second messengers in netrin-1 signaling (Homo sapiens)


spindle assembly involved in female meiosis


regulation of toll-like receptor 7 signaling pathway


postsynaptic neurotransmitter receptor activity


mitotic DNA replication checkpoint signaling


RNA splicing, via endonucleolytic cleavage and ligation


folic acid transmembrane transporter activity


regulation of cilium-dependent cell motility


endoplasmic reticulum-plasma membrane tethering