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"urn:uuid:0f2bc5be-3e4a-4fb2-9283-1d717d7835a8", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:text-mining-provider-cooccurrence", "resource_role": "primary_knowledge_source", "upstream_resource_ids": [ "infores:pubmed" ] }, { "id": "urn:uuid:eb38ce89-5e6a-4c66-89f4-38d5e8bb540d", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:pubmed", "resource_role": "supporting_data_source" } ], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "has_supporting_studies": { "urn:uuid:227ccb4a-73b2-4072-a38c-76141729807a": { "id": "urn:uuid:227ccb4a-73b2-4072-a38c-76141729807a", "category": [ "biolink:Study" ], "has_study_results": [ { "id": "tmkp:03378b253c68f775600215df3f10a21745729f4b6c792f36cb49495b18d9c8aa", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMID:8232983" ], "supporting_text": [ "Vigabatrin has been shown to aggravate \"nonprogressive myoclonic epilepsies.\"" ] }, { "id": "tmkp:2fa5df1a055b87724ab34f2cc98701500ae349795b39fd8762209993a6688ab7", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMID:11520320" ], "supporting_text": [ "Because carbamazepine (CBZ), phenytoin (PHT), tiagabine (TGB), vigabatrin (VGB), and gabapentin (GBP) may precipitate or aggravate absence and/or myoclonic jerks, their role in IGE syndromes associated with multiple seizure types is limited mostly to adjunctive use in patients unresponsive to first-line therapy." ] }, { "id": "tmkp:59d6b47519aae51103cb707d555609f1c7de62ba741964425c2dd8c9aa715367", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMID:11071486" ], "supporting_text": [ "Vigabatrin was given in only one case, in association with carbamazepine, and provoked a mixed absence and myoclonic status." ] }, { "id": "tmkp:91e39acb5a11f6d86ecd2893d94e3ead7647695845ce031affd6794a7e6435df", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMC4515334" ], "supporting_text": [ "More recently, lamotrigine, topiramate, gabapentin, carbamazepine, phenytoin, tiagabine, and vigabatrin are no longer prescribed as they may aggravate absence seizures or myoclonic jerks." ] }, { "id": "tmkp:2e51d8bd979b09b1a316fcc8398da6abdf792cc71f9e43000164bf9e78011a0c", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMID:11143506" ], "supporting_text": [ "[Acute encephalopathy and myoclonic status induced by vigabatrin monotherapy] ." ] } ] } }, "original_subject": "DRUGBANK:DB01080", "original_object": "HP:0001336" }, { "id": "urn:uuid:fdcdcf07-4ff9-4356-88d8-4bb300999546", "category": [ "biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation" ], "subject": "CHEBI:23924", "predicate": "biolink:treats", "object": "HP:0002119", "sources": [ { "id": "urn:uuid:2f756532-103b-47b9-b8d7-a0af738e5734", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:text-mining-provider-cooccurrence", "resource_role": "primary_knowledge_source", "upstream_resource_ids": [ 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barrier and composition of gut microbiota, such as LPSs and deoxycholic acid (DCA), promote the development of CLD and HCC by inducing chronic liver inflammation and injury." ] } ] } }, "original_subject": "DRUGBANK:DB08809", "original_object": "MONDO:0002251" }, { "id": "urn:uuid:8d96b2dd-52a2-4937-9cfe-756a4ea5eba9", "category": [ "biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation" ], "subject": "NCBIGene:213", "predicate": "biolink:treats", "object": "MONDO:0005798", "sources": [ { "id": "urn:uuid:b25fc74d-60ea-4170-9866-cc3446794986", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:text-mining-provider-cooccurrence", "resource_role": "primary_knowledge_source", "upstream_resource_ids": [ "infores:pubmed" ] }, { "id": "urn:uuid:504a875a-c80a-4b7a-abc4-d6b0c915e008", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:pubmed", "resource_role": "supporting_data_source" } ], "knowledge_level": "not_provided", "agent_type": 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"DRUGBANK:DB00062", "original_object": "MONDO:0005798" }, { "id": "urn:uuid:23698f02-943d-4d97-ba64-8ad0c9ec6680", "category": [ "biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation" ], "subject": "MONDO:0004992", "predicate": "biolink:treats", "object": "CHEBI:3962", "sources": [ { "id": "urn:uuid:db4488ec-875a-407e-bc31-48a10a37e2e9", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:text-mining-provider-cooccurrence", "resource_role": "primary_knowledge_source", "upstream_resource_ids": [ "infores:pubmed" ] }, { "id": "urn:uuid:cacf40c9-f144-436f-a9ba-0baa048b326c", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:pubmed", "resource_role": "supporting_data_source" } ], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "has_supporting_studies": { "urn:uuid:ec2c46ad-a9d8-4ad6-aef5-67aeecd03788": { "id": "urn:uuid:ec2c46ad-a9d8-4ad6-aef5-67aeecd03788", "category": [ "biolink:Study" ], "has_study_results": [ { "id": "tmkp:1c8209d1ae5dfd5dba6e170db6c51e790cf4fb4c81bdaec91eb0916aa2122ca4", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMID:29512668" ], "supporting_text": [ "The in vitro cytotoxicity test of the free curcumin, free nanocarrier (AuNPs@GFMS), curcumin-loaded folate-conjugated nanocarriers (Cur-AuNPs@GFMS), and curcumin-loaded nanocarriers without folate-conjugation (Cur-AuNPs@GAMS) against two human cancer cell lines, including MCF-7 (human breast carcinoma cell lines) and A549 (human lung carcinoma cell lines) demonstrated that the therapeutic efficacy of Cur-AuNPs@GFMS is significantly greater than those of other compounds because the cancerous cells can uptake the folate-conjugated drug nanocarrier via a receptor-mediated mechanism." ] }, { "id": "tmkp:91e596668ddd4bf144321588b7e9535c444a580f4744069b49e429bb860a7006", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMID:29512668" ], "supporting_text": [ "The in vitro cytotoxicity test of the free curcumin, free nanocarrier (AuNPs@GFMS), curcumin-loaded folate-conjugated nanocarriers (Cur-AuNPs@GFMS), and curcumin-loaded nanocarriers without folate-conjugation (Cur-AuNPs@GAMS) against two human cancer cell lines, including MCF-7 (human breast carcinoma cell lines) and A549 (human lung carcinoma cell lines) demonstrated that the therapeutic efficacy of Cur-AuNPs@GFMS is significantly greater than those of other compounds because the cancerous cells can uptake the folate-conjugated drug nanocarrier via a receptor-mediated mechanism." ] } ] } }, "original_subject": "MONDO:0004992", "original_object": "DRUGBANK:DB11672" }, { "id": "urn:uuid:55db8c07-f365-40e6-b378-fe1ddcdfbbff", "category": [ "biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation" ], "subject": "UMLS:C2093603", "predicate": "biolink:treats", "object": "HP:0001945", "sources": [ { "id": "urn:uuid:9943024c-35df-4835-9c5c-56c84801b2c3", "category": [ "biolink:RetrievalSource" ], "resource_id": 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"tmkp:58a2fdfaf1959577f4daf63e9596d4a90ed21683e62531b82761bbc7fde8bfdc", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMID:27321242" ], "supporting_text": [ "In an in vivo rabbit model, fever and hypokalemia synergistically prolonged the QT interval." ] } ] } }, "original_subject": "DRUGBANK:DB10415", "original_object": "HP:0001945" }, { "id": "urn:uuid:d0ec7255-78b1-476d-85aa-7ed210aae303", "category": [ "biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation" ], "subject": "CHEBI:25681", "predicate": "biolink:contributes_to", "object": "HP:0002017", "sources": [ { "id": "urn:uuid:bfabec2f-575b-4ef4-ac89-f2bef77cf47d", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:text-mining-provider-cooccurrence", "resource_role": "primary_knowledge_source", "upstream_resource_ids": [ "infores:pubmed" ] }, { "id": "urn:uuid:8c2b9169-312a-4b63-9cc9-eea86172c079", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:pubmed", "resource_role": 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"tmkp:54ddd02c0b718dd05e0a0a897530c8ff2da76fce70eede77e2f6b7bdc4d9a176", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMC4389700" ], "supporting_text": [ "Menopause is characterized by a decrease in estrogen, which triggers the uncomfortable symptoms of hot flushes, night sweats, sleep disturbances, and vaginal dryness." ] } ] } }, "original_subject": "CHEBI:50114", "original_object": "HP:0002360" }, { "id": "urn:uuid:3f719f99-d862-4ba8-aad0-c94616f5afd5", "category": [ "biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation" ], "subject": "DRUGBANK:DB15794", "predicate": "biolink:treats", "object": "MONDO:0006517", "sources": [ { "id": "urn:uuid:98f4c0e2-9ea5-4a52-bf9e-4d749d608926", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:text-mining-provider-cooccurrence", "resource_role": "primary_knowledge_source", "upstream_resource_ids": [ "infores:pubmed" ] }, { "id": "urn:uuid:ebb373dd-60cb-49b7-8de0-023670b1036c", "category": [ 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elicited by either gamma-butyrolactone (GBL), baclofen (BAC) or low doses of GABAA receptor antagonists; pentylenetetrazole (PTZ), picrotoxin (PTX) and bicuculline (BMC)." ] }, { "id": "tmkp:e94d85eed20d8df8f39aef1e894bd74aee016f8fc8cdf4502ebae1ff6734f4d9", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMC6927250" ], "supporting_text": [ "Mice lacking mGluR4 showed marked resistance to absence seizures induced by low doses of GABAA receptor antagonists, such as PTZ, picrotoxin or bicuculline." ] } ] } }, "original_subject": "DRUGBANK:DB00466", "original_object": "HP:0002121" }, { "id": "urn:uuid:86aa4dd8-cbfb-4081-8f83-7f87756b7717", "category": [ "biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation" ], "subject": "CHEBI:61538", "predicate": "biolink:contributes_to", "object": "HP:0000969", "sources": [ { "id": "urn:uuid:06c2bc11-255b-4947-ab61-469c95bfc851", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:text-mining-provider-cooccurrence", 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"category": [ "biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation" ], "subject": "CHEBI:75958", "predicate": "biolink:treats", "object": "HP:0002153", "sources": [ { "id": "urn:uuid:93657dd3-95d3-4141-8863-4876e889db05", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:text-mining-provider-cooccurrence", "resource_role": "primary_knowledge_source", "upstream_resource_ids": [ "infores:pubmed" ] }, { "id": "urn:uuid:774451f5-7971-4f42-a3b2-9c102d4cb19f", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:pubmed", "resource_role": "supporting_data_source" } ], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "has_supporting_studies": { "urn:uuid:52c0a3c3-a4ec-4eeb-a762-fe5b96dc4fd4": { "id": "urn:uuid:52c0a3c3-a4ec-4eeb-a762-fe5b96dc4fd4", "category": [ "biolink:Study" ], "has_study_results": [ { "id": "tmkp:2dbd82381e36e40a3057eec85d3520f5bc1969d1924f092a7a7a706e23bf4c02", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMID:31400980" ], "supporting_text": [ "The purpose of the study was to determine if a BC solution prevents the incidence of hyperchloremia and hyperkalemia during renal transplantation." ] }, { "id": "tmkp:386bd36a454ead004cf28219d67a19be7783ab24703a639ac1430c07c0c482d9", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMC7249430" ], "supporting_text": [ "The secondary objectives are to determine whether peri-operative IV therapy using Plasmalyte, compared with 0.9% saline, (1) improves the recovery of graft function in the first week after transplantation; (2) reduces the number of dialysis treatments required and the duration of dialysis dependence after transplantation; (3) reduces the incidence and severity of hyperkalemia; (4) improves graft survival and death-censored graft survival at 12?months; (5) improves graft function up to 12?months post-transplant; (6) improves health-related quality of life; (7) reduces hospital length of stay and health-related costs; and (8) is cost-effective." ] } ] } }, "original_subject": "CHEBI:75958", "original_object": "HP:0002153" }, { "id": "urn:uuid:92ef22fb-ce6c-48b4-a65a-3713a852180f", "category": [ "biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation" ], "subject": "MONDO:0021117", "predicate": "biolink:treats", "object": "NCBIGene:213", "sources": [ { "id": "urn:uuid:64c3fcde-ca5f-403d-847e-4e85e25ce9ad", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:text-mining-provider-cooccurrence", "resource_role": "primary_knowledge_source", "upstream_resource_ids": [ "infores:pubmed" ] }, { "id": "urn:uuid:677b94fc-793b-43a1-aa2b-62c4534eef0a", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:pubmed", "resource_role": "supporting_data_source" } ], "knowledge_level": "not_provided", "agent_type": "text_mining_agent", "has_supporting_studies": { "urn:uuid:a083c356-8b18-4653-a3ba-1df7d6a49781": { "id": "urn:uuid:a083c356-8b18-4653-a3ba-1df7d6a49781", 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had received the first dose of Covid-19-Vaccine (AZD1222, AstraZeneca) followed by an episode of chills, fever, headache and tiredness for two days." ] }, { "id": "tmkp:7cd3f3d5001a5057337effd71cb68328899de373b770999bf32101f2d7a7ad41", "category": [ "biolink:TextMiningStudyResult" ], "xref": [ "PMC8143905" ], "supporting_text": [ "Common side effects that have been reported with the Covishield? vaccine include fatigue, chills, headache, fever, flu-like symptoms." ] } ] } }, "original_subject": "DRUGBANK:DB15656", "original_object": "HP:0001945" }, { "id": "urn:uuid:c129ad7f-399e-4eae-a06f-6c10a8175508", "category": [ "biolink:ChemicalEntityToDiseaseOrPhenotypicFeatureAssociation" ], "subject": "MONDO:0005578", "predicate": "biolink:contributes_to", "object": "CHEBI:3815", "sources": [ { "id": "urn:uuid:20f73511-f3a8-4be6-a284-0737e87f116b", "category": [ "biolink:RetrievalSource" ], "resource_id": "infores:text-mining-provider-cooccurrence", "resource_role": "primary_knowledge_source", 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