{ "@id": "https://stars.renci.org/var/translator/releases/ttd/2025_12_15/", "@type": "sc:Dataset", "name": "ttd", "description": "A knowledge graph built for the NCATS Biomedical Data Translator project using Translator-Ingests, Biolink Model, and Node Normalizer.", "license": "MIT", "url": "https://stars.renci.org/var/translator/releases/ttd/2025_12_15/", "version": "2025_12_15", "dateCreated": "2025_12_15", "biolinkVersion": "4.3.6", "babelVersion": "2025sep1", "distribution": [ { "@id": "ttd.tar.xz", "@type": "cr:FileObject", "contentUrl": "ttd.tar.xz", "encodingFormat": "application/x-xz", "description": "Compressed tar archive containing the KGX files: nodes.jsonl and edges.jsonl" } ], "isBasedOn": [ { "id": "ttd", "name": "Therapeutic Target Database (TTD) Reference Ingest Guide", "description": "TTD is a database providing information about the known and explored therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets.", "license": { "terms_of_use_description": "No formal license. Andrew Su has emailed developers and gotten a positive response for use with 'proper attribution'. Papers describe resource as 'freely accessible to all users'." }, "url": [ "Downloads page: https://db.idrblab.net/ttd/full-data-download" ], "version": "2024_03_30" } ], "schema": { "nodes": [ { "category": [ "biolink:SmallMolecule" ], "count": 20029, "id_prefixes": { "PUBCHEM.COMPOUND": 13538, "CHEBI": 3499, "UNII": 2992 }, "attributes": { "name": 20029, "equivalent_identifiers": 20029, "information_content": 3498 } }, { "category": [ "biolink:Drug", "biolink:SmallMolecule" ], "count": 1675, "id_prefixes": { "CHEBI": 1523, "UNII": 139, "PUBCHEM.COMPOUND": 13 }, "attributes": { "name": 1675, "equivalent_identifiers": 1675, "information_content": 1501 } }, { "category": [ "biolink:Drug" ], "count": 67, "id_prefixes": { "CHEBI": 47, "UNII": 14, "PUBCHEM.COMPOUND": 6 }, "attributes": { "name": 67, "equivalent_identifiers": 67, "information_content": 44 } }, { "category": [ "biolink:MolecularMixture" ], "count": 911, "id_prefixes": { "PUBCHEM.COMPOUND": 487, "UNII": 327, "CHEBI": 97 }, "attributes": { "name": 911, "equivalent_identifiers": 911, "information_content": 97 } }, { "category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "count": 38, "id_prefixes": { "CHEBI": 32, "UNII": 5, "PUBCHEM.COMPOUND": 1 }, "attributes": { "name": 38, "equivalent_identifiers": 38, "information_content": 30 } }, { "category": [ "biolink:Disease" ], "count": 775, "id_prefixes": { "MONDO": 759, "EFO": 12, "DOID": 2, "OMIM": 2 }, "attributes": { "name": 775, "equivalent_identifiers": 775, "information_content": 767 } }, { "category": [ "biolink:PhenotypicFeature" ], "count": 131, "id_prefixes": { "HP": 97, "NCIT": 29, "EFO": 5 }, "attributes": { "name": 131, "equivalent_identifiers": 131, "information_content": 128 } }, { "category": [ "biolink:Gene", "biolink:Protein" ], "count": 1805, "id_prefixes": { "NCBIGene": 1805 }, "attributes": { "name": 1805, "equivalent_identifiers": 1805, "information_content": 1749 } }, { "category": [ "biolink:Protein" ], "count": 133, "id_prefixes": { "UniProtKB": 133 }, "attributes": { "name": 133, "equivalent_identifiers": 133, "information_content": 54 } } ], "nodes_summary": { "total_count": 25564, "id_prefixes": { "PUBCHEM.COMPOUND": 14045, "CHEBI": 5198, "UNII": 3477, "NCBIGene": 1805, "MONDO": 759, "UniProtKB": 133, "HP": 97, "NCIT": 29, "EFO": 17, "DOID": 2, "OMIM": 2 }, "attributes": { "name": 25564, "equivalent_identifiers": 25564, "information_content": 7868 } }, "edges": [ { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 26135, "primary_knowledge_sources": { "infores:ttd": 26135 }, "qualifiers": { "causal_mechanism_qualifier": 389 }, "attributes": { "id": 26135, "category": 26135, "knowledge_level": 26135, "agent_type": 26135, "original_subject": 26135, "original_object": 26135 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 18559, "CHEBI": 4635, "UNII": 2941 }, "object_id_prefixes": { "NCBIGene": 26135 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 1159, "primary_knowledge_sources": { "infores:ttd": 1159 }, "qualifiers": {}, "attributes": { "id": 1159, "category": 1159, "knowledge_level": 1159, "agent_type": 1159, "original_subject": 1159, "original_object": 1159 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 885, "CHEBI": 143, "UNII": 131 }, "object_id_prefixes": { "MONDO": 1138, "EFO": 18, "OMIM": 3 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 27794, "primary_knowledge_sources": { "infores:ttd": 27794 }, "qualifiers": { "object_aspect_qualifier": 27794, "causal_mechanism_qualifier": 27794, "object_direction_qualifier": 26067, "qualified_predicate": 26067 }, "attributes": { "id": 27794, "category": 27794, "knowledge_level": 27794, "agent_type": 27794, "original_subject": 27794, "original_object": 27794 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 18936, "CHEBI": 5216, "UNII": 3642 }, "object_id_prefixes": { "NCBIGene": 27794 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Protein" ], "count": 16, "primary_knowledge_sources": { "infores:ttd": 16 }, "qualifiers": {}, "attributes": { "id": 16, "category": 16, "knowledge_level": 16, "agent_type": 16, "original_subject": 16, "original_object": 16 }, "subject_id_prefixes": { "CHEBI": 16 }, "object_id_prefixes": { "UniProtKB": 16 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:treats", "object_category": [ "biolink:Disease" ], "count": 1380, "primary_knowledge_sources": { "infores:ttd": 1380 }, "qualifiers": {}, "attributes": { "id": 1380, "category": 1380, "knowledge_level": 1380, "agent_type": 1380, "original_subject": 1380, "original_object": 1380 }, "subject_id_prefixes": { "CHEBI": 1279, "UNII": 93, "PUBCHEM.COMPOUND": 8 }, "object_id_prefixes": { "MONDO": 1356, "EFO": 20, "OMIM": 3, "DOID": 1 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:in_clinical_trials_for", "object_category": [ "biolink:Disease" ], "count": 536, "primary_knowledge_sources": { "infores:ttd": 536 }, "qualifiers": {}, "attributes": { "id": 536, "category": 536, "knowledge_level": 536, "agent_type": 536, "original_subject": 536, "original_object": 536 }, "subject_id_prefixes": { "CHEBI": 414, "UNII": 119, "PUBCHEM.COMPOUND": 3 }, "object_id_prefixes": { "MONDO": 522, "OMIM": 8, "EFO": 6 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Protein" ], "count": 1086, "primary_knowledge_sources": { "infores:ttd": 1086 }, "qualifiers": { "object_aspect_qualifier": 1086, "causal_mechanism_qualifier": 1086, "object_direction_qualifier": 940, "qualified_predicate": 940 }, "attributes": { "id": 1086, "category": 1086, "knowledge_level": 1086, "agent_type": 1086, "original_subject": 1086, "original_object": 1086 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 561, "CHEBI": 328, "UNII": 197 }, "object_id_prefixes": { "UniProtKB": 1086 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 1228, "primary_knowledge_sources": { "infores:ttd": 1228 }, "qualifiers": { "causal_mechanism_qualifier": 56 }, "attributes": { "id": 1228, "category": 1228, "knowledge_level": 1228, "agent_type": 1228, "original_subject": 1228, "original_object": 1228 }, "subject_id_prefixes": { "CHEBI": 1136, "UNII": 86, "PUBCHEM.COMPOUND": 6 }, "object_id_prefixes": { "NCBIGene": 1228 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 780, "primary_knowledge_sources": { "infores:ttd": 780 }, "qualifiers": { "object_aspect_qualifier": 780, "causal_mechanism_qualifier": 780, "object_direction_qualifier": 585, "qualified_predicate": 585 }, "attributes": { "id": 780, "category": 780, "knowledge_level": 780, "agent_type": 780, "original_subject": 780, "original_object": 780 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 415, "UNII": 299, "CHEBI": 66 }, "object_id_prefixes": { "NCBIGene": 780 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Protein" ], "count": 964, "primary_knowledge_sources": { "infores:ttd": 964 }, "qualifiers": { "causal_mechanism_qualifier": 29 }, "attributes": { "id": 964, "category": 964, "knowledge_level": 964, "agent_type": 964, "original_subject": 964, "original_object": 964 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 518, "CHEBI": 313, "UNII": 133 }, "object_id_prefixes": { "UniProtKB": 964 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:in_clinical_trials_for", "object_category": [ "biolink:Disease" ], "count": 2779, "primary_knowledge_sources": { "infores:ttd": 2779 }, "qualifiers": {}, "attributes": { "id": 2779, "category": 2779, "knowledge_level": 2779, "agent_type": 2779, "original_subject": 2779, "original_object": 2779 }, "subject_id_prefixes": { "UNII": 1502, "CHEBI": 735, "PUBCHEM.COMPOUND": 542 }, "object_id_prefixes": { "MONDO": 2706, "EFO": 42, "OMIM": 30, "DOID": 1 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:treats", "object_category": [ "biolink:Disease" ], "count": 528, "primary_knowledge_sources": { "infores:ttd": 528 }, "qualifiers": {}, "attributes": { "id": 528, "category": 528, "knowledge_level": 528, "agent_type": 528, "original_subject": 528, "original_object": 528 }, "subject_id_prefixes": { "CHEBI": 401, "PUBCHEM.COMPOUND": 83, "UNII": 44 }, "object_id_prefixes": { "MONDO": 524, "EFO": 3, "OMIM": 1 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Protein" ], "count": 52, "primary_knowledge_sources": { "infores:ttd": 52 }, "qualifiers": { "object_aspect_qualifier": 52, "causal_mechanism_qualifier": 52, "object_direction_qualifier": 29, "qualified_predicate": 29 }, "attributes": { "id": 52, "category": 52, "knowledge_level": 52, "agent_type": 52, "original_subject": 52, "original_object": 52 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 29, "UNII": 21, "CHEBI": 2 }, "object_id_prefixes": { "UniProtKB": 52 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 1638, "primary_knowledge_sources": { "infores:ttd": 1638 }, "qualifiers": { "object_aspect_qualifier": 1638, "causal_mechanism_qualifier": 1638, "object_direction_qualifier": 1213, "qualified_predicate": 1213 }, "attributes": { "id": 1638, "category": 1638, "knowledge_level": 1638, "agent_type": 1638, "original_subject": 1638, "original_object": 1638 }, "subject_id_prefixes": { "CHEBI": 1520, "UNII": 109, "PUBCHEM.COMPOUND": 9 }, "object_id_prefixes": { "NCBIGene": 1638 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:in_preclinical_trials_for", "object_category": [ "biolink:Disease" ], "count": 163, "primary_knowledge_sources": { "infores:ttd": 163 }, "qualifiers": {}, "attributes": { "id": 163, "category": 163, "knowledge_level": 163, "agent_type": 163, "original_subject": 163, "original_object": 163 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 80, "CHEBI": 56, "UNII": 27 }, "object_id_prefixes": { "MONDO": 162, "OMIM": 1 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:treats", "object_category": [ "biolink:PhenotypicFeature" ], "count": 78, "primary_knowledge_sources": { "infores:ttd": 78 }, "qualifiers": {}, "attributes": { "id": 78, "category": 78, "knowledge_level": 78, "agent_type": 78, "original_subject": 78, "original_object": 78 }, "subject_id_prefixes": { "CHEBI": 67, "UNII": 7, "PUBCHEM.COMPOUND": 4 }, "object_id_prefixes": { "HP": 59, "NCIT": 18, "EFO": 1 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:treats", "object_category": [ "biolink:PhenotypicFeature" ], "count": 222, "primary_knowledge_sources": { "infores:ttd": 222 }, "qualifiers": {}, "attributes": { "id": 222, "category": 222, "knowledge_level": 222, "agent_type": 222, "original_subject": 222, "original_object": 222 }, "subject_id_prefixes": { "CHEBI": 211, "UNII": 9, "PUBCHEM.COMPOUND": 2 }, "object_id_prefixes": { "HP": 160, "NCIT": 56, "EFO": 6 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 328, "primary_knowledge_sources": { "infores:ttd": 328 }, "qualifiers": {}, "attributes": { "id": 328, "category": 328, "knowledge_level": 328, "agent_type": 328, "original_subject": 328, "original_object": 328 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 276, "UNII": 28, "CHEBI": 24 }, "object_id_prefixes": { "HP": 163, "EFO": 116, "NCIT": 49 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 587, "primary_knowledge_sources": { "infores:ttd": 587 }, "qualifiers": { "causal_mechanism_qualifier": 14 }, "attributes": { "id": 587, "category": 587, "knowledge_level": 587, "agent_type": 587, "original_subject": 587, "original_object": 587 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 335, "UNII": 201, "CHEBI": 51 }, "object_id_prefixes": { "NCBIGene": 587 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 42, "primary_knowledge_sources": { "infores:ttd": 42 }, "qualifiers": {}, "attributes": { "id": 42, "category": 42, "knowledge_level": 42, "agent_type": 42, "original_subject": 42, "original_object": 42 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 22, "UNII": 16, "CHEBI": 4 }, "object_id_prefixes": { "MONDO": 41, "OMIM": 1 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 31, "primary_knowledge_sources": { "infores:ttd": 31 }, "qualifiers": { "object_aspect_qualifier": 31, "causal_mechanism_qualifier": 31, "object_direction_qualifier": 25, "qualified_predicate": 25 }, "attributes": { "id": 31, "category": 31, "knowledge_level": 31, "agent_type": 31, "original_subject": 31, "original_object": 31 }, "subject_id_prefixes": { "CHEBI": 18, "PUBCHEM.COMPOUND": 12, "UNII": 1 }, "object_id_prefixes": { "NCBIGene": 31 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 61, "primary_knowledge_sources": { "infores:ttd": 61 }, "qualifiers": { "causal_mechanism_qualifier": 3 }, "attributes": { "id": 61, "category": 61, "knowledge_level": 61, "agent_type": 61, "original_subject": 61, "original_object": 61 }, "subject_id_prefixes": { "CHEBI": 57, "UNII": 3, "PUBCHEM.COMPOUND": 1 }, "object_id_prefixes": { "NCBIGene": 61 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 105, "primary_knowledge_sources": { "infores:ttd": 105 }, "qualifiers": {}, "attributes": { "id": 105, "category": 105, "knowledge_level": 105, "agent_type": 105, "original_subject": 105, "original_object": 105 }, "subject_id_prefixes": { "CHEBI": 101, "UNII": 3, "PUBCHEM.COMPOUND": 1 }, "object_id_prefixes": { "MONDO": 103, "EFO": 2 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:in_clinical_trials_for", "object_category": [ "biolink:Disease" ], "count": 267, "primary_knowledge_sources": { "infores:ttd": 267 }, "qualifiers": {}, "attributes": { "id": 267, "category": 267, "knowledge_level": 267, "agent_type": 267, "original_subject": 267, "original_object": 267 }, "subject_id_prefixes": { "UNII": 143, "PUBCHEM.COMPOUND": 102, "CHEBI": 22 }, "object_id_prefixes": { "MONDO": 260, "OMIM": 4, "EFO": 3 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 85, "primary_knowledge_sources": { "infores:ttd": 85 }, "qualifiers": {}, "attributes": { "id": 85, "category": 85, "knowledge_level": 85, "agent_type": 85, "original_subject": 85, "original_object": 85 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 66, "CHEBI": 12, "UNII": 7 }, "object_id_prefixes": { "NCBIGene": 85 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:in_clinical_trials_for", "object_category": [ "biolink:PhenotypicFeature" ], "count": 217, "primary_knowledge_sources": { "infores:ttd": 217 }, "qualifiers": {}, "attributes": { "id": 217, "category": 217, "knowledge_level": 217, "agent_type": 217, "original_subject": 217, "original_object": 217 }, "subject_id_prefixes": { "UNII": 121, "CHEBI": 50, "PUBCHEM.COMPOUND": 46 }, "object_id_prefixes": { "HP": 174, "NCIT": 35, "EFO": 8 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:in_clinical_trials_for", "object_category": [ "biolink:Disease" ], "count": 13, "primary_knowledge_sources": { "infores:ttd": 13 }, "qualifiers": {}, "attributes": { "id": 13, "category": 13, "knowledge_level": 13, "agent_type": 13, "original_subject": 13, "original_object": 13 }, "subject_id_prefixes": { "CHEBI": 10, "PUBCHEM.COMPOUND": 2, "UNII": 1 }, "object_id_prefixes": { "MONDO": 13 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:treats", "object_category": [ "biolink:Disease" ], "count": 55, "primary_knowledge_sources": { "infores:ttd": 55 }, "qualifiers": {}, "attributes": { "id": 55, "category": 55, "knowledge_level": 55, "agent_type": 55, "original_subject": 55, "original_object": 55 }, "subject_id_prefixes": { "CHEBI": 35, "UNII": 16, "PUBCHEM.COMPOUND": 4 }, "object_id_prefixes": { "MONDO": 53, "EFO": 2 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:in_clinical_trials_for", "object_category": [ "biolink:PhenotypicFeature" ], "count": 48, "primary_knowledge_sources": { "infores:ttd": 48 }, "qualifiers": {}, "attributes": { "id": 48, "category": 48, "knowledge_level": 48, "agent_type": 48, "original_subject": 48, "original_object": 48 }, "subject_id_prefixes": { "CHEBI": 42, "UNII": 6 }, "object_id_prefixes": { "HP": 35, "NCIT": 10, "EFO": 3 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Protein" ], "count": 148, "primary_knowledge_sources": { "infores:ttd": 148 }, "qualifiers": { "object_aspect_qualifier": 148, "causal_mechanism_qualifier": 148, "object_direction_qualifier": 75, "qualified_predicate": 75 }, "attributes": { "id": 148, "category": 148, "knowledge_level": 148, "agent_type": 148, "original_subject": 148, "original_object": 148 }, "subject_id_prefixes": { "CHEBI": 133, "UNII": 15 }, "object_id_prefixes": { "UniProtKB": 148 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 66, "primary_knowledge_sources": { "infores:ttd": 66 }, "qualifiers": { "object_aspect_qualifier": 66, "causal_mechanism_qualifier": 66, "object_direction_qualifier": 59, "qualified_predicate": 59 }, "attributes": { "id": 66, "category": 66, "knowledge_level": 66, "agent_type": 66, "original_subject": 66, "original_object": 66 }, "subject_id_prefixes": { "CHEBI": 61, "UNII": 4, "PUBCHEM.COMPOUND": 1 }, "object_id_prefixes": { "NCBIGene": 66 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:treats", "object_category": [ "biolink:Disease" ], "count": 149, "primary_knowledge_sources": { "infores:ttd": 149 }, "qualifiers": {}, "attributes": { "id": 149, "category": 149, "knowledge_level": 149, "agent_type": 149, "original_subject": 149, "original_object": 149 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 68, "CHEBI": 49, "UNII": 32 }, "object_id_prefixes": { "MONDO": 145, "EFO": 4 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 16, "primary_knowledge_sources": { "infores:ttd": 16 }, "qualifiers": {}, "attributes": { "id": 16, "category": 16, "knowledge_level": 16, "agent_type": 16, "original_subject": 16, "original_object": 16 }, "subject_id_prefixes": { "CHEBI": 14, "UNII": 2 }, "object_id_prefixes": { "NCBIGene": 16 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:in_clinical_trials_for", "object_category": [ "biolink:PhenotypicFeature" ], "count": 36, "primary_knowledge_sources": { "infores:ttd": 36 }, "qualifiers": {}, "attributes": { "id": 36, "category": 36, "knowledge_level": 36, "agent_type": 36, "original_subject": 36, "original_object": 36 }, "subject_id_prefixes": { "UNII": 23, "PUBCHEM.COMPOUND": 12, "CHEBI": 1 }, "object_id_prefixes": { "HP": 31, "NCIT": 3, "EFO": 2 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:treats", "object_category": [ "biolink:PhenotypicFeature" ], "count": 5, "primary_knowledge_sources": { "infores:ttd": 5 }, "qualifiers": {}, "attributes": { "id": 5, "category": 5, "knowledge_level": 5, "agent_type": 5, "original_subject": 5, "original_object": 5 }, "subject_id_prefixes": { "CHEBI": 5 }, "object_id_prefixes": { "HP": 4, "NCIT": 1 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Protein" ], "count": 91, "primary_knowledge_sources": { "infores:ttd": 91 }, "qualifiers": { "causal_mechanism_qualifier": 17 }, "attributes": { "id": 91, "category": 91, "knowledge_level": 91, "agent_type": 91, "original_subject": 91, "original_object": 91 }, "subject_id_prefixes": { "CHEBI": 78, "UNII": 13 }, "object_id_prefixes": { "UniProtKB": 91 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:in_preclinical_trials_for", "object_category": [ "biolink:Disease" ], "count": 12, "primary_knowledge_sources": { "infores:ttd": 12 }, "qualifiers": {}, "attributes": { "id": 12, "category": 12, "knowledge_level": 12, "agent_type": 12, "original_subject": 12, "original_object": 12 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 5, "UNII": 5, "CHEBI": 2 }, "object_id_prefixes": { "MONDO": 12 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 21, "primary_knowledge_sources": { "infores:ttd": 21 }, "qualifiers": {}, "attributes": { "id": 21, "category": 21, "knowledge_level": 21, "agent_type": 21, "original_subject": 21, "original_object": 21 }, "subject_id_prefixes": { "CHEBI": 11, "PUBCHEM.COMPOUND": 10 }, "object_id_prefixes": { "NCBIGene": 21 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:interacts_with", "object_category": [ "biolink:Protein" ], "count": 1, "primary_knowledge_sources": { "infores:ttd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 1 }, "object_id_prefixes": { "UniProtKB": 1 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:in_preclinical_trials_for", "object_category": [ "biolink:PhenotypicFeature" ], "count": 23, "primary_knowledge_sources": { "infores:ttd": 23 }, "qualifiers": {}, "attributes": { "id": 23, "category": 23, "knowledge_level": 23, "agent_type": 23, "original_subject": 23, "original_object": 23 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 15, "UNII": 6, "CHEBI": 2 }, "object_id_prefixes": { "NCIT": 12, "HP": 11 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:treats", "object_category": [ "biolink:Disease" ], "count": 15, "primary_knowledge_sources": { "infores:ttd": 15 }, "qualifiers": {}, "attributes": { "id": 15, "category": 15, "knowledge_level": 15, "agent_type": 15, "original_subject": 15, "original_object": 15 }, "subject_id_prefixes": { "CHEBI": 12, "UNII": 3 }, "object_id_prefixes": { "MONDO": 14, "EFO": 1 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:treats", "object_category": [ "biolink:PhenotypicFeature" ], "count": 21, "primary_knowledge_sources": { "infores:ttd": 21 }, "qualifiers": {}, "attributes": { "id": 21, "category": 21, "knowledge_level": 21, "agent_type": 21, "original_subject": 21, "original_object": 21 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 8, "UNII": 8, "CHEBI": 5 }, "object_id_prefixes": { "HP": 17, "NCIT": 3, "EFO": 1 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Protein" ], "count": 16, "primary_knowledge_sources": { "infores:ttd": 16 }, "qualifiers": { "object_aspect_qualifier": 16, "object_direction_qualifier": 16, "causal_mechanism_qualifier": 16, "qualified_predicate": 16 }, "attributes": { "id": 16, "category": 16, "knowledge_level": 16, "agent_type": 16, "original_subject": 16, "original_object": 16 }, "subject_id_prefixes": { "CHEBI": 16 }, "object_id_prefixes": { "UniProtKB": 16 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Protein" ], "count": 30, "primary_knowledge_sources": { "infores:ttd": 30 }, "qualifiers": { "causal_mechanism_qualifier": 2 }, "attributes": { "id": 30, "category": 30, "knowledge_level": 30, "agent_type": 30, "original_subject": 30, "original_object": 30 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 17, "UNII": 11, "CHEBI": 2 }, "object_id_prefixes": { "UniProtKB": 30 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Protein" ], "count": 6, "primary_knowledge_sources": { "infores:ttd": 6 }, "qualifiers": { "object_aspect_qualifier": 6, "causal_mechanism_qualifier": 6, "object_direction_qualifier": 5, "qualified_predicate": 5 }, "attributes": { "id": 6, "category": 6, "knowledge_level": 6, "agent_type": 6, "original_subject": 6, "original_object": 6 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 5, "CHEBI": 1 }, "object_id_prefixes": { "UniProtKB": 6 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:in_preclinical_trials_for", "object_category": [ "biolink:Disease" ], "count": 17, "primary_knowledge_sources": { "infores:ttd": 17 }, "qualifiers": {}, "attributes": { "id": 17, "category": 17, "knowledge_level": 17, "agent_type": 17, "original_subject": 17, "original_object": 17 }, "subject_id_prefixes": { "CHEBI": 17 }, "object_id_prefixes": { "MONDO": 17 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:in_clinical_trials_for", "object_category": [ "biolink:Disease" ], "count": 7, "primary_knowledge_sources": { "infores:ttd": 7 }, "qualifiers": {}, "attributes": { "id": 7, "category": 7, "knowledge_level": 7, "agent_type": 7, "original_subject": 7, "original_object": 7 }, "subject_id_prefixes": { "CHEBI": 5, "UNII": 2 }, "object_id_prefixes": { "MONDO": 7 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:interacts_with", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 5, "primary_knowledge_sources": { "infores:ttd": 5 }, "qualifiers": {}, "attributes": { "id": 5, "category": 5, "knowledge_level": 5, "agent_type": 5, "original_subject": 5, "original_object": 5 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 4, "CHEBI": 1 }, "object_id_prefixes": { "NCBIGene": 5 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 7, "primary_knowledge_sources": { "infores:ttd": 7 }, "qualifiers": {}, "attributes": { "id": 7, "category": 7, "knowledge_level": 7, "agent_type": 7, "original_subject": 7, "original_object": 7 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 6, "UNII": 1 }, "object_id_prefixes": { "HP": 7 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:directly_physically_interacts_with", "object_category": [ "biolink:Protein" ], "count": 6, "primary_knowledge_sources": { "infores:ttd": 6 }, "qualifiers": { "causal_mechanism_qualifier": 1 }, "attributes": { "id": 6, "category": 6, "knowledge_level": 6, "agent_type": 6, "original_subject": 6, "original_object": 6 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 5, "CHEBI": 1 }, "object_id_prefixes": { "UniProtKB": 6 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 2, "primary_knowledge_sources": { "infores:ttd": 2 }, "qualifiers": {}, "attributes": { "id": 2, "category": 2, "knowledge_level": 2, "agent_type": 2, "original_subject": 2, "original_object": 2 }, "subject_id_prefixes": { "CHEBI": 2 }, "object_id_prefixes": { "HP": 2 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 1, "primary_knowledge_sources": { "infores:ttd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "CHEBI": 1 }, "object_id_prefixes": { "MONDO": 1 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 1, "primary_knowledge_sources": { "infores:ttd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "CHEBI": 1 }, "object_id_prefixes": { "MONDO": 1 } } ], "edges_summary": { "total_count": 69079, "predicates": { "biolink:affects": 31617, "biolink:directly_physically_interacts_with": 29139, "biolink:in_clinical_trials_for": 3903, "biolink:treats": 2453, "biolink:studied_to_treat": 1645, "biolink:in_preclinical_trials_for": 215, "biolink:interacts_with": 107 }, "primary_knowledge_sources": { "infores:ttd": 69079 }, "predicates_by_knowledge_source": { "infores:ttd": { "biolink:affects": 31617, "biolink:directly_physically_interacts_with": 29139, "biolink:in_clinical_trials_for": 3903, "biolink:treats": 2453, "biolink:studied_to_treat": 1645, "biolink:in_preclinical_trials_for": 215, "biolink:interacts_with": 107 } }, "qualifiers": { "causal_mechanism_qualifier": 32128, "object_aspect_qualifier": 31617, "object_direction_qualifier": 29014, "qualified_predicate": 29014 }, "attributes": { "id": 69079, "category": 69079, "knowledge_level": 69079, "agent_type": 69079, "original_subject": 69079, "original_object": 69079 } } } }